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Your search keyword '"Yu, Honghong"' showing total 27 results
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27 results on '"Yu, Honghong"'

13. Mesenchymal stem cells inhibit MRP-8/14 expression and neutrophil migration via TSG-6 in the treatment of lupus nephritis

Author

Zhang, Lingli, primary, Chen, Weiwei, additional, Xia, Nan, additional, Wu, Dan, additional, Yu, Honghong, additional, Zheng, Yuanyuan, additional, Chen, Hongwei, additional, Fei, Fei, additional, Geng, Linyu, additional, Wen, Xin, additional, Liu, Shanshan, additional, Wang, Dandan, additional, Liang, Jun, additional, Shen, Wei, additional, Jin, Ziyi, additional, Li, Xiaojing, additional, Yao, Genhong, additional, and Sun, Lingyun, additional

Published
2023
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20. An integrated strategy by using target tissue metabolomics biomarkers as pharmacodynamic surrogate indices to screen antipyretic components of Qingkaikling injection

Author

Zhang, Zhixin, primary, Lu, Fang, additional, Liu, Haiyu, additional, Zhao, Huizhen, additional, Liu, Yuehong, additional, Fu, Shuang, additional, Wang, Meiling, additional, Xie, Ziye, additional, Yu, Honghong, additional, Huang, Zhenghai, additional, Zhang, Yanling, additional, and Gao, Xiaoyan, additional

Published
2017
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21. Applying characteristic fragment filtering for rapid detection and identification of ingredients in rhubarb by HPLC coupled with linear ion trap-Orbitrap mass spectrometry

Author

Wang, Qing, primary, Lu, Zhiwei, additional, Zhang, Li, additional, Zhang, Qingqing, additional, Wang, Meiling, additional, Zhao, Huizhen, additional, Liu, Yuehong, additional, Fu, Shuang, additional, Huang, Zhenghai, additional, Xie, Ziye, additional, Yu, Honghong, additional, Zhang, Zhixin, additional, and Gao, Xiaoyan, additional

Published
2017
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22. Back Cover: Characterization of the potential new phthalides in Ligusticum chuanxiong Hort. using ultra-performance liquid chromatography coupled with quadrupole time of flight tandem mass spectrometry

Author

Zhang, Qingqing, primary, Wang, Meiling, additional, Wang, Qing, additional, Zhao, Huizhen, additional, Zhang, Zhixin, additional, Yu, Honghong, additional, Liu, Yuehong, additional, Fu, Shuang, additional, Lu, Zhiwei, additional, Huang, Zhenghai, additional, Xie, Ziye, additional, Gao, Xiaoyan, additional, and Qiao, Yanjiang, additional

Published
2017
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23. Characterization of the potential new phthalides in Ligusticum chuanxiong Hort. using ultra-performance liquid chromatography coupled with quadrupole time of flight tandem mass spectrometry

Author

Zhang, Qingqing, primary, Wang, Meiling, additional, Wang, Qing, additional, Zhao, Huizhen, additional, Zhang, Zhixin, additional, Yu, Honghong, additional, Liu, Yuehong, additional, Fu, Shuang, additional, Lu, Zhiwei, additional, Huang, Zhenghai, additional, Xie, Ziye, additional, Gao, Xiaoyan, additional, and Qiao, Yanjiang, additional

Published
2017
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24. Pharmacometabolomics in Endogenous Drugs: A New Approach for Predicting the Individualized Pharmacokinetics of Cholic Acid

Author

Zhang, Zhixin, Gu, Hao, Zhao, Huizhen, Liu, Yuehong, Fu, Shuang, Wang, Meiling, Zhou, Wenjuan, Xie, Ziye, Yu, Honghong, Huang, Zhenghai, and Gao, Xiaoyan

Abstract

The evaluation of individual variability in endogenous drugs’ metabolism and disposition is a very challenging task. We developed and validated a metabotype to pharmacokinetics (PK) matching approach by taking cholic acid as an example to predict the individualized PK of endogenous drugs. The stable isotope-labeled cholic acid was selected as the substitute analyte of cholic acid to ensure the accurate measurement of blood concentration. First, large-scale metabolite profiling studies were performed on the predose urine samples of 28 rats. Then, to examine the individualized PK of deuterium 4-cholic acid (d4-cholic acid) in these rats, we determined its plasma concentrations and calculated the differential AUC values. Subsequently, we conducted a two-stage partial least-squares analysis in which 31 baseline metabolites were screened initially for predicting the individualized AUC values of d4-cholic acid using the data of predose urine metabolites. Finally, network biology analysis was applied to give the biological interpretation of the individual variances in cholic acid metabolism and disposition, and the result further narrowed the selection of baseline metabolites from 31 to 2 (sarcosine and S-adenosyl-l-homocysteine) for such prediction. Collectively, this pharmacometabolomics research provided a new strategy for predicting individualized PK of endogenous drugs.

Published
2024
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26. Effect and mechanism of ferulic acid inclusion complexes on tyramine production by Enterobacter hormaecheiMW386398 in smoked horsemeat sausages

Author

Huang, Yali, Yu, Honghong, Lu, Shiling, Zou, Liangjun, Tang, Zonggui, Zeng, Tao, and Tang, Juan

Abstract

Ferulic acid inclusion complexes (FA-HP-β-CD) effects on tyramine accumulation and gene expression of Enterobacter hormaecheiMW386398 in traditional smoked horsemeat sausages were studied. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to identify the expression of tyrosine decarboxylase (TDC) clusters in the tyramine producing pathway. In addition, relevant parameters such as microbial growth, moisture content, pH, and tyramine accumulation in pure cultures and during fermentation of smoked horsemeat sausages were evaluated. Ferulic acid (FA) and FA-HP-β-CD inclusion complexes both significantly decreased tyramine accumulation, as well as significantly inhibited tyrosine decarboxylase (tdcA) and tyrosine/tyramine antiporter (tyrP) genes expression (p < 0.05). Furthermore, FA and FA-HP-β-CD inclusion complexes both reduced the number of Enterobacteriaceaein smoked horsemeat sausages, but did not alter the main microbiota. However, FA-HP-β-CD inclusion complexes exhibited stronger ability in hindering TDC related gene expression, reducing tyramine accumulation and antibacterial properties. These results indicate that FA-HP-β-CD inclusion complexes are able to reduce tyramine accumulation in smoked horsemeat sausages by inhibiting Enterobacteriaceaegrowth and gene expression.

Published
2021
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27. Curcumin protects human umbilical vein endothelial cells against high oxidized low density lipoprotein-induced lipotoxicity and modulates autophagy.

Author

Zhao L, Luo R, Yu H, Li S, Yu Q, Wang W, Cai K, Xu T, Chen R, and Tian W

Abstract

Objectives: Endothelial dysfunction is a precursor of cardiovascular disease, and protecting endothelial cells from damage is a treatment strategy for atherosclerosis (AS). Curcumin, a natural polyphenolic compound, has been shown to protect endothelial cells from dysfunction. In the present study, we investigated whether curcumin could ameliorate high oxidized low-density lipoprotein (ox-LDL)-induced endothelial lipotoxicity by inducing autophagy in human umbilical vein endothelial cells (HUVECs)., Materials and Methods: HUVECs were treated with 50 μM high ox-LDL alone or in combination with 5 μM curcumin for 24 hr. Cell viability and function were assessed by the cell counting kit-8 (CCK-8) assay, tube formation assay and cell migration experiments. Oil red O staining was used to detect lipid droplet accumulation in HUVECs. The change in reactive oxygen species (ROS) levels in HUVECs was measured with the probe DCFH-DA. Quantitative real-time PCR (qPCR) and Western blotting were used to evaluate the mRNA and protein levels of several inflammatory and autophagy-related factors., Results: Cell viability was restored, tube formation and migration ability were increased, and lipid accumulation, oxidative stress and inflammatory responses were decreased in the curcumin-treated group compared with the high ox-LDL group. Furthermore, high ox-LDL inhibited HUVEC autophagy, and this effect was reversed by curcumin. Moreover, curcumin regulated the expression of several key proteins involved in the AMPK/mTOR/p70S6K signaling pathway., Conclusion: Our findings suggest that curcumin is able to reduce endothelial lipotoxicity and modulate autophagy and that the AMPK/mTOR/p70S6K pathway might play a key role in these effects.

Published
2021
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