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This study aims to examine the associations among social support, coping styles, and resilience in parents of children with orofacial clefts (OFCs). We conducted a cross-sectional study. Through convenience sampling, 306 parents of children with OFCs completed questionnaires on social support, coping styles, and resilience. Pearson's correlations and hierarchical regression analyses were used to examine the relationships among the selected variables. The results showed that age, gender, educational level, diagnosis of children, severity of OFCs, social support, and positive coping style had significant associations with resilience, which jointly explained 69.1% of the total variance in resilience. The findings suggested that social support and a positive coping style may be instrumental in improving resilience. Further research is required to explore interventions to improve the resilience of parents of children with OFCs. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study is to investigate the association between family management and asthma control in children with asthma. Design and Methods: This cross‐sectional descriptive study recruited 142 children with asthma and their parents. We used the Family Management Measure (FaMM), the Childhood Asthma Control Test (C‐ACT), and fractional exhaled nitric oxide (FeNO) detectors to assess family management and asthma control. The McNemar's test was used to determine the proportional difference between C‐ACT and FeNO in evaluating asthma control. Pearson correlation analysis and multiple linear regression analysis were used to assess the relationship between family management and asthma control in children with asthma. Results: There was no significant difference in the proportion of C‐ACT and FeNO in evaluating asthma control (McNemar's test p =.593). Child's Daily Life, Condition Management Ability, and Parental Mutuality were positively correlated with C‐ACT (r = 0.398 to 0.655; all p <.05) and negatively correlated with FeNO (r = −0.245 to −0.402; all p <.05); Condition Management Effort, Family Life Difficulty, and View of Condition Impact were negatively correlated with C‐ACT (r = −0.416 to −0.672; all p <.05) and positively with FeNO (r = 0.248 to 0.427; all p < 0.05). Child's Daily Life, Condition Management Effort, and View of Condition Impact dimensions significantly predicted the C‐ACT results, and the Condition Management Effort and View of Condition Impact dimensions significantly predicted the FeNO results (p <.05). Practical Implications: Pediatric nurses could provide family management education for parents to improve asthma control in children. In addition, pediatric nurses might assess asthma control condition of asthmatic children in combination with C‐ACT and FeNO levels. [ABSTRACT FROM AUTHOR]

With the development of mobile communication technology, smartphones have been used in point-of-care technologies (POCTs) as an important part of telemedicine. Using a multidisciplinary design principle coupling electrical engineering, software development, synthetic biology, and optogenetics, the investigators developed a smartphone-controlled semiautomatic theranostic system that regulates blood glucose homeostasis in diabetic mice in an ultraremote-control manner. The present chapter describes how the investigators tailor-designed the implant architecture "HydrogeLED," which is capable of coharboring a designer-cell-carrying alginate hydrogel and wirelessly powered far-red light LEDs. Using diabetes mellitus as a model disease, the in vivo expression of insulin or human glucagon-like peptide 1 (shGLP-1) from HydrogeLED implants could be controlled not only by pre-set ECNU-TeleMed programs, but also by a custom-engineered Bluetooth-active glucometer in a semiautomatic and glycemia-dependent manner. As a result, blood glucose homeostasis was semiautomatically maintained in diabetic mice through the smartphone-controlled semiautomatic theranostic system. By combining digital signals with optogenetically engineered cells, the present study provides a new method for the integrated diagnosis and treatment of diseases.

With the increasing indispensable role of smartphones in our daily lives, the mobile health care system coupled with embedded physical sensors and modern communication technologies make it an attractive technology for enabling the remote monitoring of an individual's health. Using a multidisciplinary design principle coupled with smart electronics, software, and optogenetics, the investigators constructed smartphone-controlled optogenetic switches to enable the ultraremote-control transgene expression. A custom-designed SmartController system was programmed to process wireless signals from smartphones, enabling the regulation of therapeutic outputs production by optically engineered cells via a far-red light (FRL)-responsive optogenetic interface. In the present study, the investigators describe the details of the protocols for constructing smartphone-controlled optogenetic switches, including the rational design of an FRL-triggered transgene expression circuit, the procedure for cell culture and transfection, the implementation of the smartphone-controlled far-red light-emitting diode (LED) module, and the reporter detection assay.