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1,029 results on '"Yu, Chunyan"'

6. Correlation between Body Composition and Cardiopulmonary Exercise Capacity in Patients with Chronic Obstructive Pulmonary Disease

Author

YU Chunyan, DONG Fen, LEI Jieping, YANG Ting, XIA Jingen, QUMU Shiwei, YANG Tianyi, LI Xiaopan

Subjects
chronic obstructive pulmonary disease, cardiopulmonary exercise test, body composition, rehabilitation, multifactor linear regression, Medicine
Abstract

Background Cardiopulmonary exercise testing (CPET) is essential for assessing the maximal exercise capacity of patients with chronic obstructive pulmonary disease (COPD) and for developing rehabilitation prescriptions. Body composition has been shown to be associated with CPET results, which is complex, time-consuming, contraindicated, and risky, and cannot be performed in some COPD patients, whereas body composition analysis is simple and fast. Objective This paper focuses on the correlation between body composition and CPET in patients with COPD, and provides a basis for predicting maximal exercise capacity, formulating rehabilitation prescriptions, and rational nutritional support for patients with COPD who are unable to complete cardiopulmonary exercise testing. Methods Stable COPD patients were enrolled in the outpatient respiratory clinic of China-Japan Friendship Hospital between July 2021 and March 2022, and were sequentially subjected to body composition measurements and CPET with continuous incremental loading, and the test results were analyzed to assess the relationship between body composition and CPET results, and to analyze the value of the body composition indexes in predicting the results of CPET. Results Seventy-seven eligible patients with stable COPD completed body composition measurement and exercise cardiopulmonary exercise testing. Correlation analysis showed that body fat percentage (BFP) was negatively correlated with peak metabolic equivalents (peakMETs) (P

Published
2024
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33. Research on Online and Offline Mixed Teaching Quality Evaluation of Higher Mathematics Based on Hierarchical Analysis Method

Author

Wang, Junyan, Yu, Chunyan, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Fu, Weina, editor, and Sun, Guanglu, editor

Published
2022
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34. Design of Online Teaching Method for Subject Knowledge of Mathematics Teachers in Higher Vocational Colleges Based on Convolutional Neural Network

Author

Yu, Chunyan, Wang, Junyan, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Fu, Weina, editor, and Sun, Guanglu, editor

Published
2022
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45. Single‐cell transcriptome analysis deciphers the CD74‐mediated immune evasion and tumour growth in lung squamous cell carcinoma with chronic obstructive pulmonary disease.

Author

Wang, Denian, Li, Sixiang, Yang, Zhi, Yu, Chunyan, Wu, Pengfei, Yang, Ying, Zhang, Rui, Li, Qingyan, Yang, Jian, Li, Hongchun, Ji, Guiyi, Wang, Yan, Xie, Kang, Liu, Yanyan, Wang, Kaige, Zhu, Daxing, Zhang, Wengeng, Liu, Dan, Chen, Bojiang, and Li, Weimin

Subjects
T-cell exhaustion, CHRONIC obstructive pulmonary disease, SQUAMOUS cell carcinoma, MULTISPECTRAL imaging, T cells
Abstract

Background: Chronic obstructive pulmonary disease (COPD) contributes to the incidence and prognosis of lung cancer. The presence of COPD significantly increases the risk of lung squamous cell carcinoma (LSCC). COPD may promote an immunosuppressive microenvironment in LSCC by regulating the expression of immune‐inhibitory factors in T cells, although the mechanisms remain unclear. In this study, we aimed to decipher the tumour microenvironment signature for LSCC with COPD at a single‐cell level. Methods: We performed single‐cell RNA sequencing on tumour tissues from LSCC with or without COPD, then investigated the features of the immune and tumour cells. We employed multiple techniques, including multispectral imaging, flow cytometry, tissue microarray analysis, survival analysis, co‐culture systems and in vitro and in vivo treatment experiments, to validate the findings obtained from single‐cell analyses. Results: LSCC with COPD showed increased proportions of tumour‐associated macrophages (TAMs) and higher levels of CD8+ T cell exhaustion molecules, which contributed to an immunosuppressive microenvironment. Further analysis revealed a critical cluster of CD74+ tumour cells that expressed both epithelial and immune cell signatures, exhibited a stronger capacity for tumorigenesis and predicted worse overall survival. Notably, migration inhibitory factor (MIF) secreted by TAMs from LSCC with COPD may promote the activation of CD74. MIF‐CD74 may interact with CD8+ T cells and impair their anti‐tumour activity by regulating the PI3K‐STAT3‐programmed cell death‐1 ligand 1 signalling pathway, facilitating tumour proliferation and immune evasion. Conclusions: Our comprehensive picture of the tumour ecosystem in LSCC with COPD provides deeper insights into relevant immune evasion mechanisms and potential targets for immunotherapy. Highlight: Our results demonstrated higher proportions of tumour‐associated macrophages (TAMs) and higher levels of exhaustion molecules in CD8+ T cells in the microenvironment of LSCC with COPD.CD74+tumour cells were associated with poor disease prognosis.Migration inhibitory factor (MIF)‐CD74 may interact with CD8+ T cells and impair their anti‐tumour activity by regulating the PI3K‐STAT3‐PD‐L1 signalling pathway, facilitating immune evasion. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Adipocyte‑rich microenvironment promotes chemoresistance via upregulation of peroxisome proliferator‑activated receptor gamma/ABCG2 in epithelial ovarian cancer

Author

Chen, Siqi, primary, Liu, Zixuan, additional, Wu, Haixia, additional, Wang, Bo, additional, Ouyang, Yuqing, additional, Liu, Junru, additional, Zheng, Xiaoyan, additional, Zhang, Haoke, additional, Li, Xueying, additional, Feng, Xiaofan, additional, Li, Yan, additional, Shen, Yangyang, additional, Zhang, Hong, additional, Xiao, Bo, additional, Yu, Chunyan, additional, and Deng, Weimin, additional

Published
2024
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49. A Weighted Fusion Method for UAV Hyperspectral Image Splicing

Author

Wang, Yulei, Shi, Yao, Zhu, Qingyu, Wu, Di, Yu, Chunyan, Song, Meiping, Liu, Anliang, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Wang, Wei, editor, Liu, Xin, editor, Na, Zhenyu, editor, Jia, Min, editor, and Zhang, Baoju, editor

Published
2020
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50. Joint Kurtosis–Skewness-Based Background Smoothing for Local Hyperspectral Anomaly Detection

Author

Wang, Yulei, Zhao, Yiming, Xia, Yun, Chang, Chein-I, Song, Meiping, Yu, Chunyan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martin, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Liu, Xin, editor, Na, Zhenyu, editor, Wang, Wei, editor, Mu, Jiasong, editor, and Zhang, Baoju, editor

Published
2020
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