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246 results on '"Yu, Chunping"'

2. Standard: Human intestinal cancer organoids

Author

Lin, Hanqing, Wang, Yalong, Cheng, Chunyan, Qian, Yuxin, Hao, Jie, Zhang, Zhen, Sheng, Weiqi, Song, Linhong, Deng, Chu-Xia, Zhao, Bing, Cao, Jiani, Wang, Lei, Wang, Liu, Liang, Lingmin, Chen, Wenli Kelly, Yu, Chunping, Sun, Zhijian, Yang, Yingying, Wang, Changlin, Zhang, Yong, Li, Qiyuan, Li, Ka, Ma, Aijin, Zhao, Tongbiao, Chen, Ye-Guang, and Hua, Guoqiang

Published
2023
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3. Association of computed tomography-based body composition with survival in metastatic renal cancer patient received immunotherapy: a multicenter, retrospective study

Author

Wang, Jun, Dong, Pei, Qu, Yuanyuan, Xu, Wenhao, Zhou, Zhaohui, Ning, Kang, Peng, Yulu, Xiong, Longbin, Li, Zhen, Zou, Xiangpeng, Liu, Zhenhua, Li, Mingzhao, He, Zhisong, Luo, Junhang, Tian, Xi, Zhang, Hailiang, Guo, Shengjie, Han, Hui, Zhou, Fangjian, Yin, Shaohan, Ye, Dingwei, Yu, Chunping, and Zhang, Zhiling

Published
2023
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10. What Happens to the Preserved Renal Parenchyma After Clamped Partial Nephrectomy?

Author

Xiong, Longbin, Nguyen, Jane K., Peng, Yulu, Zhou, Zhaohui, Ning, Kang, Jia, Nan, Nie, Jing, Wen, Dongxiang, Wu, Zeshen, Roversi, Gustavo, Palacios, Diego Aguilar, Abramczyk, Emily, Munoz-Lopez, Carlos, Campbell, Jack A., Cao, Yun, Li, Wencai, Zhang, Xuepei, He, Zhisong, Li, Xiang, Huang, Jiwei, Shou, Jianzhong, Wu, Jitao, Chen, Minfeng, Chen, Xiaofeng, Zheng, Jiaxuan, Xu, Congjie, Zhong, Wen, Li, Zaishang, Dong, Wen, Zhao, Juping, Zhang, Hailang, Luo, Junhang, Liu, Jianye, Sun, Fanghu, Han, Hui, Guo, Shengjie, Dong, Pei, Zhou, Fangjian, Yu, Chunping, Campbell, Steven C., and Zhang, Zhiling

Published
2022
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14. Comparative Study on Domestic and International Standards of DC Electric Energy Meter

Author

YU Chunping, DUAN Yongxian, LI Xiong, CEN Wei, MENG Jing, and LIU Si

Subjects
dc networks, iec, electric energy metering equipment, dc electric energy meter, standardization, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

With the decarbonization of energy sectors and the development of DC power grid and the DC charging technology for electric vehicles， DC energy measurement has become a hot topic both at home and abroad. In order to promote the development of relevant research in China， the latest released IEC（International Electrotechnical Commission）standards of DC energy meter are compared with China's existing national standard and the pattern evaluation program， and the main differences such as the scope of application， accuracy requirements and influence test items are analyzed. The results show that in the IEC standard voltage and current scopes of electric meters are wider and influence quantity test items including conduction differential mode current are added； in addition， specifications and immunity evaluation methods for DC electric meters must be improved as soon as possible so that the DC electric energy meters can better fulfill the requirements of engineering practice.

Published
2022
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17. Extraperitonealization of the ileal conduit decreases the risk of parastomal hernia: A single-center, randomized clinical trial

Author

Zhou, Zhaohui, primary, Xiong, Longbin, additional, Yao, Kai, additional, Ma, Huali, additional, Wei, Wensu, additional, Zhang, Zhiling, additional, Guo, Shengjie, additional, Dong, Pei, additional, Li, Xiangdong, additional, Jiang, Lijuan, additional, Chen, Dong, additional, Qin, Zike, additional, Han, Hui, additional, Ye, Yunlin, additional, Li, Yonghong, additional, Wang, Yanjun, additional, Wu, Zhiming, additional, Tian, Li, additional, Yu, Chunping, additional, Zhou, Fangjian, additional, Li, Zhiyong, additional, and Liu, Zhuowei, additional

Published
2023
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18. Longitudinal changes in renal parenchymal volume and function status after partial nephrectomy: A retrospective cohort study

Author

Xiong, Longbin, primary, Zou, Xiangpeng, additional, Luo, Xin, additional, Yin, Shaohan, additional, Huang, Yixin, additional, Ning, Kang, additional, Wen, Dongxiang, additional, Zhou, Zhaohui, additional, Wang, Jun, additional, Li, Zhen, additional, Chen, Jiawei, additional, Li, Jibin, additional, Peng, Wei, additional, Guo, Shengjie, additional, Dong, Pei, additional, Zhou, Fangjian, additional, Han, Hui, additional, Peng, Yulu, additional, Yu, Chunping, additional, and Zhang, Zhiling, additional

Published
2023
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19. Trimethylamine-N-oxide (TMAO) and predicted risk of cardiovascular events after partial nephrectomy.

Author

Zou, Xiangpeng, Xiong, Longbin, Guo, Zhixing, Li, Yuchen, Ning, Kang, Liu, Xiaohua, Xie, Ye, Peng, Yulu, Liu, Yixuan, Cai, Xinyang, Zhao, Boxin, Zhou, Fangjian, Yu, Chunping, Zheng, Xia, Campbell, Steven C., and Zhang, Zhiling

Abstract

Emerging evidence suggests that uremic toxins, in particular trimethylamine-N-oxide(TMAO), indoxyl-sulfate(IS), and p-cresyl-sulfate(PCS), may associate with increased risk of cardiovascular events(CVe). However, whether uremic toxins increase after partial nephrectomy(PN) and their correlation with risk for CVe remains unknown. 100 patients managed with PN were retrospectively reviewed. TMAO/IS/PCS levels were examined by liquid chromatography-mass-spectrometry. Renal-parenchymal-volume-preservation(RPVP) was estimated from CT scans. Predicted risks for CVe were obtained using the Framingham score. Linear regression assessed association between uremic toxins, GFR and risk of CVe. Logistic regression evaluated factors associated with post-PN TMAO. TMAO, IS and PCS increased from 1.7, 3.7 and 3.5 μmol/L before PN to 3.6, 5.4 and 7.4 μmol/L at latest follow-up, respectively, while GFR declined from 102 to 93 ml/min/1.73 m2 (all p<0.001). TMAO, IS and PCS levels all negatively correlated with GFR(all p<0.001). Predicted 10-year risk of CVe increased from 1.1% pre-PN to 1.7% post-PN(p<0.001), primarily due to increased age(p<0.001), blood pressure(p = 0.002) and total cholesterol(p = 0.003). TMAO(β = 0.038) and GFR (β = −0.02) were independent predictors for predicted 10-year CVe risk on multivariable-analysis. Increased TMAO was an early and sustained finding maintained through 5 years, unlike IS, PCS and eGFR. On multivariable analysis, increased pre-PN TMAO(OR = 2.79) and decreased RPVP(OR = 3.23) were identified as independent risk factors for higher post-PN TMAO, while ischemia type/duration failed to correlate. Uremic toxin levels increased after PN correlating with reduced GFR. Higher TMAO independently associated with greater predicted 10-year CVe risk. Parenchymal mass preserved rather than ischemia time or type associated with increased TMAO. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Trimethylamine-N-oxide (TMAO) and predicted risk of cardiovascular events after partial nephrectomy

Author

Zou, Xiangpeng, primary, Xiong, Longbin, additional, Guo, Zhixing, additional, Li, Yuchen, additional, Ning, Kang, additional, Liu, Xiaohua, additional, Xie, Ye, additional, Peng, Yulu, additional, Liu, Yixuan, additional, Cai, Xinyang, additional, Zhao, Boxin, additional, Zhou, Fangjian, additional, Yu, Chunping, additional, Zheng, Xia, additional, Campbell, Steven C., additional, and Zhang, Zhiling, additional

Published
2023
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21. Supplemental Table 2 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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22. Supplemental Figure 8 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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23. Supplemental Table 5 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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24. Data from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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25. Supplemental Table 6 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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26. Supplemental Table 3 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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27. Supplemental Table 8 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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28. Supplemental Figure 4 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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29. Supplemental Figure 3 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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30. Supplemental Figure 6 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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31. Supplemental Table 7 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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32. Supplemental Figure 2 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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33. Supplementary Data from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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34. Supplemental Figure 1 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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35. Supplemental Table 1 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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36. Supplemental Figure 9 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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37. Supplemental Figure 5 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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38. Supplemental Figure 7 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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39. Supplemental Table 4 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Author

Wander, Seth A., primary, Cohen, Ofir, primary, Gong, Xueqian, primary, Johnson, Gabriela N., primary, Buendia-Buendia, Jorge E., primary, Lloyd, Maxwell R., primary, Kim, Dewey, primary, Luo, Flora, primary, Mao, Pingping, primary, Helvie, Karla, primary, Kowalski, Kailey J., primary, Nayar, Utthara, primary, Waks, Adrienne G., primary, Parsons, Stephen H., primary, Martinez, Ricardo, primary, Litchfield, Lacey M., primary, Ye, Xiang S., primary, Yu, Chunping, primary, Jansen, Valerie M., primary, Stille, John R., primary, Smith, Patricia S., primary, Oakley, Gerard J., primary, Chu, Quincy S., primary, Batist, Gerald, primary, Hughes, Melissa E., primary, Kremer, Jill D., primary, Garraway, Levi A., primary, Winer, Eric P., primary, Tolaney, Sara M., primary, Lin, Nancy U., primary, Buchanan, Sean G., primary, and Wagle, Nikhil, primary

Published
2023
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45. Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8+ T-cells highly infiltrated in males.

Author

Ning, Kang, Peng, Yulu, Jiang, Yue, Li, Zhen, Luo, Xin, Lin, Lede, Deng, Minhua, Wu, Yi, Huang, Tingxuan, Huang, Yixin, Xie, Ye, Yang, Xiaofeng, Zhang, Manhuai, Xiong, Longbin, Zou, Xiangpeng, Zhou, Zhaohui, Zhou, Fangjian, Dong, Pei, Yu, Chunping, and Zhang, Zhiling

Subjects
ANDROGEN receptors, RENAL cell carcinoma, T cells, ALPHA fetoproteins, IMMUNE checkpoint inhibitors, SEXISM, CANCER cells
Abstract

Background: Although sex bias has been reported in the development and progression of renal cell carcinoma (RCC), the underlying mechanisms remain enigmatic. Here, we investigated the sex differences in the tumor microenvironment (TME) of RCC and explored a promising combination drug regimen to enhance the efficacy of immunotherapy. Methods: Single-cell RNA sequencing (scRNA-seq) data from four published datasets were analyzed to investigate the sex differences in RCC patients, and tumor tissues were collected to validate the sex differences using multiplex immunofluorescence (MxIF) and flow cytometry (FCM). The function of the androgen–androgen receptor axis in sex differences was explored in vivo and in vitro experiments. Results: Our analysis of scRNA-seq data from 220,156 cells, as well as MxIF and FCM assays, revealed that CD8+ T-cells infiltrated highly in the TME of male RCC, but were mostly in an exhausted and dysfunctional state. In vitro and in vivo experiments indicated that the dysfunction and exhaustion of CD8+ T-cells in male TME were induced by androgen. Clinically, higher serum androgen was significantly associated with a worse prognosis in male RCC patients receiving immunotherapy. Androgen receptor inhibitors could activate tumor-infiltrating CD8+ T-cells and enhance the efficacy of immunotherapy of RCC in vivo. Conclusions: Our study delineated the difference in TME between male and female patients with RCC, and demonstrated that the androgen–androgen receptor axis plays an important role in immunosuppression in male RCC. Our findings suggest that androgen receptor inhibitors in combination with immunotherapy may be a promising treatment option for male RCC patients. Highlights: Male renal cell carcinoma is characterized by a heightened degree of malignant cell malignancy, with classical tumorigenic pathways, including EMT, angiogenesis, and TGF-β, highly enriched in the malignant cells. No significant difference in the subsets of infiltrating myeloid cells, indicating that myeloid cells may not play a significant role in the gender bias of renal cell carcinoma. We observed a higher infiltration of CD8+ T-cells in male renal cell carcinoma, most of which were in an exhausted state. The androgen–androgen receptor axis leads to CD8+ T-cell exhaustion in male renal cell carcinoma, resulting in the compromised anti-tumor function of these cells. Androgen receptor inhibitors may hold the potential to alleviate the exhaustion of CD8+ T-cells, paving the way for a promising combination therapy with immune checkpoint inhibitors for immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Association of computed tomography-based body composition with survival in metastatic renal cancer patient received immunotherapy: a multicenter, retrospective study

Author

Wang, Jun, primary, Dong, Pei, additional, Qu, Yuanyuan, additional, Xu, Wenhao, additional, Zhou, Zhaohui, additional, Ning, Kang, additional, Peng, Yulu, additional, Xiong, Longbin, additional, Li, Zhen, additional, Zou, Xiangpeng, additional, Liu, Zhenhua, additional, Li, Mingzhao, additional, He, Zhisong, additional, Luo, Junhang, additional, Tian, Xi, additional, Zhang, Hailiang, additional, Guo, Shengjie, additional, Han, Hui, additional, Zhou, Fangjian, additional, Yin, Shaohan, additional, Ye, Dingwei, additional, Yu, Chunping, additional, and Zhang, Zhiling, additional

Published
2022
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48. Perirenal Fat Thickness Significantly Associated with Prognosis of Metastatic Renal Cell Cancer Patients Receiving Anti-VEGF Therapy

Author

Ning, Kang, primary, Li, Zhen, additional, Liu, Huiming, additional, Tian, Xi, additional, Wang, Jun, additional, Wu, Yi, additional, Xiong, Longbin, additional, Zou, Xiangpeng, additional, Peng, Yulu, additional, Zhou, Zhaohui, additional, Zhou, Fangjian, additional, Yu, Chunping, additional, Luo, Junhang, additional, Zhang, Hailiang, additional, Dong, Pei, additional, and Zhang, Zhiling, additional

Published
2022
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50. Standard: Human intestinal organoids.

Author

Wang, Yalong, Lin, Hanqing, Zhao, Lianzheng, Hong, Fan, Hao, Jie, Zhang, Zhen, Sheng, Weiqi, Song, Linhong, Deng, Chu-Xia, Zhao, Bing, Cao, Jiani, Wang, Lei, Wang, Liu, Liang, Lingmin, Chen, Wenli Kelly, Yu, Chunping, Sun, Zhijian, Yang, Yingying, Wang, Changlin, and Zhang, Yong

Abstract

Organoids have attracted great interest for disease modelling, drug discovery and development, and tissue growth and homeostasis investigations. However, lack of standards for quality control has become a prominent obstacle to limit their translation into clinic and other applications. "Human intestinal organoids" is the first guideline on human intestinal organoids in China, jointly drafted and agreed by the experts from the Chinese Society for Cell Biology and its branch society: the Chinese Society for Stem Cell Research. This standard specifies terms and definitions, technical requirements, test methods, inspection rules for human intestinal organoids, which is applicable to quality control during the process of manufacturing and testing of human intestinal organoids. It was originally released by the Chinese Society for Cell Biology on 24 September 2022. We hope that the publication of this standard will guide institutional establishment, acceptance and execution of proper practical protocols and accelerate the international standardization of human intestinal organoids for applications. [ABSTRACT FROM AUTHOR]

Published
2023
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