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Background: Commonly affecting the face, chest, and back, acne is an inflammatory disorder that can be treated with a variety of modalities, with laser treatment remaining a key option for scar treatment. This study aimed to compare the efficacy and safety of topical timolol after fractional CO2 versus fractional laser alone in the treatment of acne scars. Patients & Methods: This Interventional comparative study was carried out on 62 patients different skin types suffering from mild, moderate and severe facial acne scars, patients were divided into 2 groups; Group one: 31 patients were treated by topical timolol maleate 0.5% after fractional laser twice daily for seven days to be repeated every two weeks until complete response or for maximum of six sessions. Group two: 31 patients were treated by fractional CO2 laser alone every two weeks until complete response or for maximum of six sessions. Results: There was highly statistically significant improvement post acne scar after application of Timolol with LASER (P< 0.001). Moreover, there was statistically significant improvement post acne scar after application of Timolol with LASER. The findings suggest that the combination of topical timolol maleate with fractional CO2 laser therapy may offer enhanced benefits compared to CO2 laser treatment alone. This is evident in the observed improvements in acne scar outcomes, such as texture, pigmentation, and overall skin appearance. Conclusion: Applying topical 0.5% TM twice a day could result in a noticeable improvement, enhances the function of the skin's barrier and may encourage re-epithelialization following laser treatments. [ABSTRACT FROM AUTHOR]

BACKGROUND: Acne vulgaris is a worldwide chronic inflammatory dermatological disorder of pilosebaceous unit that adversely affects patients’ quality of life, so safe and effective treatment options are needed. Platelet rich plasma is an autologous highly concentrated platelets in a little amount of plasma. Various growth factors are released after platelet activation that have significant role in angiogenesis, inflammation and wound healing. AIM: to assess the efficacy and safety of platelet rich plasma injection in management of acne vulgaris. METHODS: Thirty patients with acne vulgaris of different severity and duration received four sessions of platelet rich plasma that injected intradermal, one session every two weeks for 8 weeks. RESULTS: The obtained results showed a statistically significant decrease in the total lesion count (P<0.05) and high statistically significant decrease in acne severity index (P<0.01) from baseline. Also, high statistically significant decrease was observed in pustules count (P<0.01) after treatment. Mild side effects were detected in the form of mild to moderate pain, erythema and edema immediately after treatment with Intradermal platelet rich plasma injection. CONCLUSIONS: Intradermal Platelet Rich Plasma injection is promising and effective treatment option for acne vulgaris with tolerable side effects. [ABSTRACT FROM AUTHOR]

Background: Inflammation of the skin marked by itchy, pigmented, dry areas is known as Atopic Dermatitis (AD), also known as Atopic Eczema (AE) or Eczema. Symptoms include red, itchy pimples that leak fluid and crust, scaly or raw skin, or raw or scaly skin. Dermatitis can come in many different forms, such as atopic, contact, or seborrheic. In children, atopic dermatitis is the most prevalent kind of eczema and often occurs in association with other allergic or asthmatic conditions. Eczema is most commonly found on the face, neck, elbows, knees, and toes, among other places. In terms of phototherapy, ultraviolet B phototherapy (280–320 nm) is the "oldest" method that is used in treatment of atopic dermatitis. Platelet rich plasma (PRP) injection utilizes the body's own regenerative mechanisms to help treat disease in the patient. Objective: Determination of the updated treatment modalities in Atopic Dermatitis management. Conclusion: Clearly there remains a need to find more potent topical agents with fewer side effects. The most gratifying advances in AD therapy have come from better understanding of immune and inflammatory mechanisms. [ABSTRACT FROM AUTHOR]