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309 results on '"Yousef, Yacoub A."'

2. Retinoblastoma in Asia: Clinical Presentation and Treatment Outcomes in 2112 Patients from 33 Countries

Author

Kaliki, Swathi, Vempuluru, Vijitha S., Mohamed, Ashik, Abdulqader, Rula Ahmed, Aggarwal, Priyanka, Ahmad, Alia, Akib, Marliyanti Nur Rahmah, Al Mesfer, Saleh A., Al Ani, Mouroge Hashim, Al-Badri, Safaa A.Faraj, Angeles Alcasabas, Ana Patricia, Al-Dahmash, Saad A., Al-Haddad, Christiane, Yahya Al-Hussaini, Hamoud Hodeish, Al-Jadiry, Mazin Faisal, Al-Jumaily, Usama, Alkatan, Hind Manaa, Razzaq Mahmood Al-Mafrachi, Ali Abdul, Samad Majeed Al-Shaheen, Athar Abdul, Al-Shammary, Entissar Hadi, Amiruddin, Primawita Oktarima, Armytasari, Inggar, Astbury, Nicholas John, Atalay, Hatice Tuba, Ataseven, Eda, Atchaneeyasakul, La-ongsri, Balayeva, Ruhengiz, Bascaran, Covadonga, Begimkulova, Ainura Suranovna, Bhaduri, Anirban, Bhat, Sunil, Bhattacharyya, Arpita, Blum, Sharon, Bowman, Richard, Buaboonnam, Jassada, Burton, Matthew J., Caspi, Shani, Chaudhry, Shabana, Chawla, Bhavna, Chen, Wensi, Chuluunbat, Tsengelmaa, Dangboon, Wantanee, Das, Anirban, Das, Pranab, Das, Sima, Du, Yi, Dudeja, Gagan, Eka Sutyawan, I Wayan, Fadoo, Zehra, Faranoush, Mohammad, Foster, Allen, Frenkel, Shahar, Ghassemi, Fariba, Gomel, Nir, Gunasekera, D Sanjeeva, Gündüz, Ahmet K., Gupta, Himika, Gupta, Sanjiv, Gupta, Vineeta, Hamid, Syed Ahmer, Hamzah, Norhafizah, Hasanreisoglu, Murat, Hassan, Shadab, Haydar, Huda Awni, Hongeng, Suradej, Hussein Al-Janabi, Allawi Noor, Islamov, Ziyavuddin, Janjua, Teyyeb Azeem, Jeeva, Irfan, Ji, Xunda, Jo, Dong Hyun, Kantar, Mehmet, Kapelushnik, Noa, Kebudi, Rejin, Keomisy, Jonny, Khan, Zohora Jameela, Khaqan, Hussain Ahmed, Khetan, Vikas, Khodabande, Alireza, Kim, Jeong Hun, Kiratli, Hayyam, Koç, Irem, Kulvichit, Kittisak, Kuntorini, Mayasari Wahyu, Li, Cairui, Li, Kaijun, Limbu, Ben, Liu, ChunHsiu, Lutfi, Delfitri, Mahajan, Amita, Maitra, Puja, Makimbetov, Emil Kojoshovich, Maktabi, Azza M.Y., Manzhuova, Lyazat, Masud, Sidra, Mehrvar, Azim, Menon, Vikas, John V Mercado, Gary, Chandra Mishra, Divyansh Kailash, Mohammad, Mona Tayseer, Mudaliar, Sangeeta Sanjay, Mushtaq, Asma, Nair, Akshay Gopinathan, Natarajan, Sundaram, Nency, Yetty Movieta, Neroev, Vladimir, Nuruddin, Murtuza, Pagarra, Halimah, Palanivelu, Mahesh Shanmugam, Papyan, Ruzanna, Pe'er, Jacob, Polyakov, Vladimir, Qadir, Ali Omer, Qayyum, Seema, Qian, Jiang, Quah, BoonLong, Rahman, Ardizal, Rajkarnikar, Purnima, Ramanjulu, Rajesh, Rashid, Riffat, Rojanaporn, Duangnate, Roy, Soma Rani, Saab, Raya Hamad, Saakyan, Svetlana, Sabhan, Ahmed Hatem, Saiju, Rohit, Sayalith, Phayvanh, Sedaghat, Ahad, Seth, Rachna, Shakoor, Shawkat Ara, Sharma, Manoj Kumar, Siddiqui, Sorath Noorani, Singh, Usha, Singha, Penny, Sitorus, Rita S., Soebagjo, Hendrian D., Sultana, Sadia, Sun, Xiantao, Supriyadi, Eddy, Surukrattanaskul, Supawan, Suzuki, Shigenobu, Tan, Deborah, Tang, Jing, Tashvighi, Maryam, Teh, Kok Hoi, Tehuteru, Edi Setiawan, Thawaba, Abdullah Dahan M., Toledano, Helen, Le Trang, Doan, Tripathy, Devjyoti, Tuncer, Samuray, Unal, Emel, Ushakova, Tatiana L., Usmanov, Rustam, Verma, Nishant, Victor, Andi Arus, Vishnevskia-Dai, Victoria, Wang, Yi-Zhuo, Wangtiraumnuay, Nutsuchar, Riono, Widiarti Pandu, Wiwatwongwana, Atchareeya, Wiwatwongwana, Damrong, Wong, Emily S., Wongwai, Phanthipha, Wu, Si-qi, Xiang, Daoman, Xiao, Yishuang, Xu, Bing, Xue, Kang, Yam, Jason C., Yang, Huasheng, Yaqub, Muhammad Amer, Yarovaya, Vera A., Yarovoy, Andrey A., Ye, Huijing, Yousef, Yacoub Abdallah, Yuliawati, Putu, Zhang, Yi, Zia, Nida, Zondervan, Marcia, Fabian, Ido Didi, and Sthapit, Purnima Rajkarnikar

Published
2024
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3. Retinoblastoma Outcomes Based on the 8th Edition American Joint Committee on Cancer Pathological Classification in 1411 Patients

Author

Ahmad, Alia, Bejjanki, Kavya Madhuri, Diaz-Coronado, Rosdali, Eiger-Moscovich, Maya, Elder, James E., Fabian, Ido Didi, Frenkel, Shahar, Grossniklaus, Hans, Hubbard, G. Baker, III, Kaliki, Swathi, Kapoor, Anasua Ganguly, Mohammad, Mona, McKenzie, John D., Pe’er, Jacob, Rath, Suryasnata, Reddy, M.Ashwin, Rolfe, Olivia, Roy, Soma Rani, Sagoo, Mandeep S., Shields, Carol L., Staffieri, Sandra E., Tanabe, Mika, Tatiana, Ushakova, Tripathy, Devjyoti, Vishnevskia-Dai, Vicktoria, Vempuluru, Vijitha S., Vladimir, Polyakov, Yousef, Yacoub A., and Berry, Jesse L.

Published
2024
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4. Comparative analysis through propensity score matching in thyroid cancer: unveiling the impact of multiple malignancies

Author

Al-Ibraheem, Akram, primary, Abdlkadir, Ahmed Saad, additional, Al-Adhami, Dhuha Ali, additional, Lopci, Egesta, additional, Al-Omari, Amal, additional, Al-Masri, Mahmoud, additional, Yousef, Yacoub, additional, Al-Hajaj, Nabeela, additional, Mohamad, Issa, additional, Singer, Susanne, additional, and Sykiotis, Gerasimos P., additional

Published
2024
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5. The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries

Author

Fabian, Ido Didi, Abdallah, Elhassan, Abdullahi, Shehu U, Abdulqader, Rula A, Abdulrahaman, Aminatu A, Abouelnaga, Sherif, Ademola-Popoola, Dupe S, Adio, Adedayo, Afifi, Mahmoud A, Afshar, Armin R, Aggarwal, Priyanka, Aghaji, Ada E, Ahmad, Alia, Akib, Marliyanti NR, Akinsete, Adeseye, Al Harby, Lamis, Al Mesfer, Saleh, Al Ani, Mouroge H, Alarcón Portabella, Silvia, Al-Badri, Safaa AF, Alcasabas, Ana Patricia A, Al-Dahmash, Saad A, Alejos, Amanda, Alemany-Rubio, Ernesto, Alfa Bio, Amadou I, Alfonso Carreras, Yvania, Al-Haddad, Christiane E, Al-Hussaini, Hamoud HY, Ali, Amany M, Alia, Donjeta B, Al-Jadiry, Mazin F, Al-Jumaily, Usama, Alkatan, Hind M, All-Eriksson, Charlotta, Al-Mafrachi, Ali ARM, Almeida, Argentino A, Alsawidi, Khalifa M, Al-Shaheen, Athar ASM, Al-Shammary, Entissar H, Amankwaa-Frempong, Doreen, Amiruddin, Primawita O, Armytasari, Inggar, Astbury, Nicholas J, Atalay, Hatice T, Ataseven, Eda, Atchaneeyasakul, La-ongsri, Atsiaya, Rose, Autrata, Rudolf, Balaguer, Julia, Balayeva, Ruhengiz, Barranco, Honorio, Bartoszek, Paulina, Bartuma, Katarina, Bascaran, Covadonga, Bechrakis, Nikolaos E, Beck Popovic, Maja, Begimkulova, Ainura S, Benmiloud, Sarra, Berete, Rokia C, Berry, Jesse L, Bhaduri, Anirban, Bhat, Sunil, Bhattacharyya, Arpita, Biewald, Eva M, Binkley, Elaine, Blum, Sharon, Bobrova, Nadia, Boldt, H.C., Bonanomi, Maria Teresa BC, Bouda, Gabrielle C, Bouguila, Hédi, Brennan, Rachel C, Brichard, Bénédicte G, Buaboonnam, Jassada, Budiongo, Aléine, Burton, Matthew J, Calderón-Sotelo, Patricia, Calle Jara, Doris A, Camuglia, Jayne E, Cano, Miriam R, Capra, Michael, Caspi, Shani, Cassoux, Nathalie, Castela, Guilherme, Castillo, Luis, Català-Mora, Jaume, Cavieres, Isabel, Chandramohan, Arthika, Chantada, Guillermo L, Chaudhry, Shabana, Chawla, Bhavna, Chen, Wensi, Chiwanga, Faraja S, Chuluunbat, Tsengelmaa, Cieslik, Krzysztof, Clark, Antony, Cockcroft, Ruellyn L, Comsa, Codruta, Correa Llano, Maria G, Corson, Timothy W, Couitchere, Line, Cowan-Lyn, Kristin E, Csóka, Monika, Dangboon, Wantanee, Das, Anirban, Das, Pranab, Das, Sima, Davanzo, Jacquelyn M, Davidson, Alan, De Francesco, Sonia, De Potter, Patrick, Quintero D, Karina, Demirci, Hakan, Desjardins, Laurence, Díaz Coronado, Rosdali Y, Dimaras, Helen, Dodgshun, Andrew J, Donato Macedo, Carla R, Dragomir, Monica D, Du, Yi, Du Bruyn, Magritha, Du Plessis, Johannes, Dudeja, Gagan, Eerme, Katrin, Eka Sutyawan, I Wayan, El Kettani, Asmaa, Elbahi, Amal M, Elder, James E, Elhaddad, Alaa M, Elhassan, Moawia MA, Elzembely, Mahmoud M, Ericksen, Connor, Essuman, Vera A, Evina, Ted Grimbert A, Ezegwui, Ifeoma R, Fadoo, Zehra, Fandiño, Adriana C, Faranoush, Mohammad, Fasina, Oluyemi, Fernández, Delia DPG, Fernández-Teijeiro, Ana, Foster, Allen, Frenkel, Shahar, Fu, Ligia D, Fuentes-Alabi, Soad L, Garcia, Juan L, García Aldana, David, Garcia Pacheco, Henry N, Geel, Jennifer A, Ghassemi, Fariba, Girón, Ana V, Goenz, Marco A, Gold, Aaron S, Goldberg, Hila, Gole, Glen A, Gomel, Nir, Gonzalez, Efren, Gonzalez Perez, Graciela, González-Rodríguez, Liudmira, Gorfine, Malka, Graells, Jaime, Gregersen, Pernille A, Grigorovski, Nathalia DAK, Guedenon, Koffi M, Gunasekera, D Sanjeeva, Gündüz, Ahmet K, Gupta, Himika, Gupta, Sanjiv, Gupta, Vineeta, Hadjistilianou, Theodora, Hamel, Patrick, Hamid, Syed A, Hamzah, Norhafizah, Hansen, Eric D, Harbour, J William, Hartnett, M. Elizabeth, Hasanreisoglu, Murat, Muhammad, Hassan, Hassan, Sadiq, Hassan, Shadab, Hautz, Wojciech, Haydar, Huda, Hederova, Stanislava, Hessissen, Laila, Hongeng, Suradej, Hordofa, Diriba F, Hubbard, G. Baker, Hummelen, Marlies, Husakova, Kristina, Hussein Al-Janabi, Allawi N, Ibanga, Affiong, Ida, Russo, Ilic, Vesna R, Islamov, Ziyavuddin, Jairaj, Vivekaraj, Janjua, Teyyeb, Jeeva, Irfan, Ji, Xunda, Jo, Dong Hyun, Jones, Michael M, Kabesha Amani, Theophile B, Kabore, Rolande L, Kaliki, Swathi, Kalinaki, Abubakar, Kamsang, Pius, Kantar, Mehmet, Kapelushnik, Noa, Kardava, Tamar, Kebudi, Rejin, Keomisy, Jonny, Kepak, Tomas, Ketteler, Petra, Khan, Zohora J, Khaqan, Hussain A, Khetan, Vikas, Khodabande, Alireza, Khotenashvili, Zaza, Kim, Jonathan W, Kim, Jeong Hun, Kiratli, Hayyam, Kivela, Tero T., Klett, Artur, Koç, Irem, Kosh Komba Palet, Jess Elio, Krivaitiene, Dalia, Kruger, Mariana, Kulvichit, Kittisak, Kuntorini, Mayasari W, Kyara, Alice, Lam, Geoffrey C, Larson, Scott A, Latinović, Slobodanka, Laurenti, Kelly D, Lavy, Yotam, Lavric Groznik, Alenka, Leverant, Amy A, Li, Cairui, Li, Kaijun, Limbu, Ben, Liu, Chun-Hsiu, Quah, BoonLong, López, Juan P, Lukamba, Robert M, Luna-Fineman, Sandra, Lutfi, Delfitri, Lysytsia, Lesia, Madgar, Shiran, Magrath, George N, Mahajan, Amita, Maitra, Puja, Maka, Erika, Makimbetov, Emil K, Maktabi, Azza, Maldonado, Carlos, Mallipatna, Ashwin, Manudhane, Rebecca, Manzhuova, Lyazat, Martín-Begue, Nieves, Masud, Sidra, Matende, Ibrahim O, Mattosinho, Clarissa CDS, Matua, Marchelo, Mayet, Ismail, Mbumba, Freddy B, McKenzie, John D, Mehrvar, Azim, Mengesha, Aemero A, Menon, Vikas, Mercado, Gary John V, Mets, Marilyn B, Midena, Edoardo, Miller, Audra, Mishra, Divyansh KC, Mndeme, Furahini G, Mohamedani, Ahmed A, Mohammad, Mona T, Moll, Annette C, Montero, Margarita M, Moreira, Claude, Mruthyunjaya, Prithvi, Msina, Mchikirwa S, Msukwa, Gerald, Mudaliar, Sangeeta S, Muma, Kangwa I M, Munier, Francis L, Murray, Timothy G, Musa, Kareem O, Mushtaq, Asma, Musika, Anne A, Mustak, Hamzah, Mustapha, Tajudeen, Muyen, Okwen M, Myezo, Khumo H, Naidu, Gita, Naidu, Natasha, Nair, Akshay Gopinathan, Natarajan, Sundaram, Naumenko, Larisa, Ndoye Roth, Paule Aïda, Nency, Yetty M, Neroev, Vladimir, Ng, Yvonne, Nikitovic, Marina, Nkanga, Elizabeth D, Nkumbe, Henry E, Numbi, Marcel N, Nummi, Kalle, Nuruddin, Murtuza, Nyaywa, Mutale, Nyirenda, Chinsisi, Obono-Obiang, Ghislaine, Oliver, Scott CN, Oporto, Joaquin, Ortega-Hernández, Miriam, Oscar, Alexander H, Ossandon, Diego, Pagarra, Halimah, Paintsil, Vivian, Paiva, Luisa, Palanivelu, Mahesh Shanmugam, Papyan, Ruzanna, Parrozzani, Raffaele, Pascual Morales, Claudia R, Paton, Katherine E, Pe'er, Jacob, Peralta Calvo, Jesús, Perić, Sanja, Pham, Chau TM, Philbert, Remezo, Plager, David A, Pochop, Pavel, Polania, Rodrigo A., Polyakov, Vladimir, Ponce, Jimena, Qadir, Ali O, Qayyum, Seema, Qian, Jiang, Refaeli, David, Rahman, Ardizal, Rajkarnikar, Purnima, Ramanjulu, Rajesh, Ramasubramanian, Aparna, Ramirez-Ortiz, Marco A, Randhawa, Jasmeen K, Randrianarisoa, Hoby Lalaina, Raobela, Léa, Rashid, Riffat, Reddy, M.A., Renner, Lorna A, Reynders, David, Ribadu, Dahiru, Ritter-Sovinz, Petra, Rogowska, Anna, Rojanaporn, Duangnate, Romero, Livia, Roy, Soma R, Saab, Raya H, Saakyan, Svetlana, Sabhan, Ahmed H, Sagoo, Mandeep S, Said, Azza MA, Saiju, Rohit, Salas, Beatriz, San Román Pacheco, Sonsoles, Sánchez, Gissela L, Sanchez Orozco, Alma Janeth, Sayalith, Phayvanh, Scanlan, Trish A, Schlüter, Sabrina, Schwab, Christoph, Sedaghat, Ahad, Seth, Rachna, Sgroi, Mariana, Shah, Ankoor S, Shakoor, Shawkat A, Sharma, Manoj K, Sherief, Sadik T, Shields, Carol L, Sia, David, Siddiqui, Sorath Noorani, Sidi cheikh, Sidi, Silva, Sónia, Singh, Arun D, Singh, Usha, Singha, Penny, Sitorus, Rita S, Skalet, Alison H, Soebagjo, Hendrian D, Sorochynska, Tetyana, Ssali, Grace, Stacey, Andrew W, Staffieri, Sandra E, Stahl, Erin D, Steinberg, David M, Stones, David K, Strahlendorf, Caron, Suarez, Maria Estela Coleoni, Sultana, Sadia, Sun, Xiantao, Superstein, Rosanne, Supriyadi, Eddy, Surukrattanaskul, Supawan, Suzuki, Shigenobu, Svojgr, Karel, Sylla, Fatoumata, Tamamyan, Gevorg, Tan, Deborah, Tandili, Alketa, Tang, Jing, Tarrillo Leiva, Fanny F, Tashvighi, Maryam, Tateshi, Bekim, Teh, Kok Hoi, Tehuteru, Edi S, Teixeira, Luiz F, Tekavcic Pompe, Manca, Thawaba, Abdullah Dahan M, Theophile, Tuyisabe, Toledano, Helen, Trang, Doan L, Traoré, Fousseyni, Tripathy, Devjyoti, Tuncer, Samuray, Tyau-Tyau, Harba, Umar, Ali B, Unal, Emel, Uner, Ogul E, Urbak, Steen F, Ushakova, Tatiana L, Usmanov, Rustam H, Valeina, Sandra, Valente, Paola, van Hoefen Wijsard, Milo, Vasquez Anchaya, Jacqueline Karina, Vaughan, Leon O, Veleva-Krasteva, Nevyana V, Verma, Nishant, Victor, Andi A, Viksnins, Maris, Villacís Chafla, Edwin G, Villegas, Victor M, Vishnevskia-Dai, Victoria, Waddell, Keith, Wali, Amina H, Wang, Yi-Zhuo, Wangtiraumnuay, Nutsuchar, Wetter, Julie, Widiarti, Widiarti, Wilson, Matthew W, Wime, Amelia DC, Wiwatwongwana, Atchareeya, Wiwatwongwana, Damrong, Wolley Dod, Charlotte, Wong, Emily S, Wongwai, Phanthipha, Wu, Si-qi, Xiang, Daoman, Xiao, Yishuang, Xu, Bing, Xue, Kang, Yaghy, Antonio, Yam, Jason C, Yang, Huasheng, Yanga, Jenny M, Yaqub, Muhammad A, Yarovaya, Vera A, Yarovoy, Andrey A, Ye, Huijing, Yee, Roberto I, Yousef, Yacoub A, Yuliawati, Putu, Zapata López, Arturo M, Zein, Ekhtelbenina, Zhang, Yi, Zhilyaeva, Katsiaryna, Zia, Nida, Ziko, Othman AO, Zondervan, Marcia, and Bowman, Richard

Published
2022
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7. Ocular and Periocular Metastasis in Breast Cancer: Clinical Characteristics, Prognostic Factors and Treatment Outcome

Author

Yousef, Yacoub A., primary, Mohammad, Mona, additional, Khalil, Hanan, additional, Khouri, Tala, additional, Alsweiti, Rand, additional, Khzouz, Jakub, additional, Abu Laban, Dima, additional, Jaradat, Imad, additional, Ibrahimi, Ahmad Kh., additional, Al-Ibraheem, Akram, additional, Masri, Mahmoud Al, additional, AlNawiaseh, Ibrahim, additional, and Abdel-Razeq, Hikmat, additional

Published
2024
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8. Assessing the Impact of Simulated Color Vision Deficiency on Ophthalmologists' Ability to Differentiate between Choroidal Melanoma and Choroidal Nevus.

Author

Yousef, Yacoub A., Alkhatib, Fawzieh, Elfalah, Mutasem, AlRyalat, Saif Aldeen, Mohammad, Mona, AlHabahbeh, Omar, AlJabari, Reem, Zweifel, Sandrine, AlNawiaseh, Ibrahim, Rejdak, Robert, and Toro, Mario Damiano

Subjects
*COLOR blindness, *NEVUS, *OPHTHALMOLOGISTS, *DIABETIC retinopathy, *MELANOMA
Abstract

Background: Color vision deficiency (CVD) is an often-overlooked issue within the medical community, and its consequences remain insufficiently explored. We aim to evaluate how CVD affects diagnostic accuracy and distinguish between malignant choroidal melanoma and benign choroidal nevus among ophthalmologists. Methods: In this cross-sectional study, we engaged ophthalmologists through a web-based survey distributed via the professional ophthalmology society's social media channels. The survey encompassed a series of three fundus images representing normal fundus, choroidal nevus, and choroidal melanoma. Each image underwent simulation for the three primary types of CVD—protanopia, deuteranopia, and tritanopia—alongside a non-simulated version. Results: The study included 41 participants, averaging 40 years of age (±9.2), comprising 28 (68%) men and 13 (32%) women. Significantly lower rates of identifying orange pigments were observed in simulated protanopia images compared to non-simulated ones (p = 0.038). In simulated deutranopia images, the recognition of melanotic lesions was notably reduced compared to non-simulated images (p = 0.048). No such limitation was observed for tritanopia. However, participants retained their ability to identify subretinal fluid and estimate tumor thickness in simulated and non-simulated images. Concerning simulated images of choroidal nevi, participants misdiagnosed nevi as choroidal melanoma in 37% of cases in simulated protanopia nevi images and 41% in simulated deutranopia nevi images. This resulted in unnecessary referrals of benign lesions as malignant, emphasizing the potential for mistaken diagnoses. Nevertheless, almost all simulated images of malignant melanoma were correctly referred for specialized oncological treatment. Conclusions: The simulated CVD conditions of protanopia and deuteranopia affected the accuracy of identifying the melanotic nature of the choroidal tumor and the presence of orange pigments. This limitation led to challenges in correctly diagnosing choroidal melanoma and choroidal nevus, resulting in extra referrals for nevus cases. However, participants were safe and could still determine the possible risk of eyes with choroidal melanoma, so most referred melanoma cases to specialized oncologists as needed. [ABSTRACT FROM AUTHOR]

Published
2024
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10. From Molecular Biology to Novel Immunotherapies and Nanomedicine in Uveal Melanoma

Author

Synoradzki, Kamil J., primary, Paduszyńska, Natalia, additional, Solnik, Malgorzata, additional, Toro, Mario Damiano, additional, Bilmin, Krzysztof, additional, Bylina, Elżbieta, additional, Rutkowski, Piotr, additional, Yousef, Yacoub A., additional, Bucolo, Claudio, additional, Zweifel, Sandrine Anne, additional, Reibaldi, Michele, additional, Fiedorowicz, Michal, additional, and Czarnecka, Anna M., additional

Published
2024
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11. Optimizing Surgical Management for Rhegmatogenous Retinal Detachment in Eyes with Active Retinoblastoma: A Safety-Driven Approach.

Author

Yousef, Yacoub A., AlHabahbeh, Omar, Mohammad, Mona, Halalsheh, Hadeel, Mehyar, Mustafa, Toro, Mario Damiano, and AlNawaiseh, Ibrahim

Subjects
*RETINAL detachment, *RETINOBLASTOMA, *RETINAL surgery, *CANCER invasiveness, *CANCER chemotherapy, *CHILD patients, *PROLIFERATIVE vitreoretinopathy
Abstract

Introduction: Intraocular surgeries are conventionally contraindicated for patients with active retinoblastoma (Rb) due to the potential risk of tumor dissemination. However, surgery is occasionally necessary to preserve vision in patients with a single eye when the eye is complicated by rhegmatogenous retinal detachment (RRD). Objective: This study aims to evaluate the outcomes of surgical repair for RRD in pediatric patients with active Rb utilizing a non-drainage scleral buckling approach. Results: This cohort included six eyes from six patients who harbored active Rb and presented with RRD; one had a concurrent tractional component. All eyes (100%) had active intraocular Rb and were undergoing active therapy (systemic chemotherapy, cryotherapy, and thermal laser therapy) when RRD developed. RRD consistently manifested at the site of recent cryotherapy in all cases. RRD repair in the affected eyes was performed by scleral buckling without subretinal fluid drainage. Five of the six eyes (83%) achieved complete retinal reattachment. One eye (17%) with a tractional component exhibited partial reattachment and was eventually enucleated due to persistent active disease. At a median follow-up of 15 months (range 12–180 months) after scleral buckling, all five eyes had persistent retinal attachment, and no case developed orbital or distant metastasis. Conclusions: Our study demonstrates that nondrainage scleral buckling is an effective and safe method for the surgical repair of RRD in eyes harboring active Rb, as most cases achieved persistent complete retinal reattachment without the risk of tumor spread. [ABSTRACT FROM AUTHOR]

Published
2024
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12. The Impact of Tumor Laterality (Unilateral vs. Bilateral) on Presentation and Management Outcome in Patients with Retinoblastoma.

Author

Mohammad, Mona, Mehyar, Mustafa, Halalsheh, Hadeel, Shehada, Reham, Al Adawi, Omar, Khzouz, Jakub, Jaradat, Imad, Al-Hussaini, Maysa, Sultan, Iyad, Alnawaiseh, Ibrahim, and Yousef, Yacoub A.

Subjects
RETINOBLASTOMA, LATERAL dominance, PATIENT compliance, METASTASIS, PATIENT education
Abstract

Background: This study compares the outcomes of managing retinoblastoma between patients with unilateral and bilateral presentations. Methods: The study, conducted at the King Hussein Cancer Center in Amman, Jordan, retrospectively analyzed cases of retinoblastoma treated between March 2003 and December 2019. Evaluation criteria included clinical features, disease stage, treatment methods, and overall management outcomes. Results: The study comprised 697 eyes from 478 patients with retinoblastoma, with 52% being males. Bilateral disease was observed in 70% of patients, and a family history of retinoblastoma was more prevalent in cases with bilateral disease (20%) compared to those with unilateral disease (4%). Unilateral cases had a median age at diagnosis of 28 months, whereas bilateral cases were diagnosed at a median age of 6 months. Extra-ocular retinoblastoma was detected in 1% of eyes. According to the International Intraocular Retinoblastoma Classification (IIRC), 88% of unilateral cases presented with advanced disease (IIRC group D/E), compared to 46% in bilateral cases. Primary enucleation was performed in 29% of unilateral cases and 16% of bilateral cases (p-value 0.0007). Eye salvage rates were 31% in unilateral cases and 68% in bilateral cases (p-value < 0.0001). At 120 months of follow-up, 5% of patients died from secondary neoplasms or metastases, 81% were alive, and 14% were lost to follow-up. There was no significant difference in metastasis, secondary neoplasms, or mortality between patients with unilateral and bilateral retinoblastoma. Conclusions: This study highlights the nuanced differences in clinical characteristics and outcomes between unilateral and bilateral retinoblastoma, emphasizing the necessity of customized management and early detection strategies. It demonstrates that while bilateral retinoblastoma benefits from earlier detection and has a higher rate of eye salvage, there is no significant difference in metastasis or mortality rates when compared to unilateral cases. The critical roles of primary enucleation in advanced cases, along with effective communication and patient education, are also underscored to improve treatment adherence. Overall, these findings point to the importance of tailored approaches in optimizing outcomes for the diverse patient population affected by retinoblastoma. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Optic Disc Swelling in Cancer Patients: Etiology and Implications

Author

Yousef, Yacoub A., primary, Sid Ahmed, Isra M., additional, Kanj Ahmad, Danah, additional, Mohammad, Mona, additional, Makahleh, Hala, additional, AlJabari, Reem, additional, Alkhatib, Fawzieh, additional, Toro, Mario Damiano, additional, Rejdak, Robert, additional, Mehyar, Mustafa, additional, and Alnawaiseh, Ibrahim, additional

Published
2023
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14. Retinoblastoma in Asia: Clinical presentation and Treatment Outcomes in 2112 patients from 33 countries

Author

Kaliki, Swathi, primary, Vempuluru, Vijitha S., additional, Mohamed, Ashik, additional, Al-Jadiry, Mazin Faisal, additional, Bowman, Richard, additional, Chawla, Bhavna, additional, Hamid, Syed Ahmer, additional, Ji, Xunda, additional, Kapelushnik, Noa, additional, Kebudi, Rejin, additional, Sthapit, Purnima Rajkarnikar, additional, Rojanaporn, Duangnate, additional, Sitorus, Rita S., additional, Yousef, Yacoub Abdallah, additional, and Fabian, Ido Didi, additional

Published
2023
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15. Causes of death and survival analysis for patients with retinoblastoma in Jordan

Author

Bilbeisi, Tharwa, primary, Almasry, Razaq, additional, Obeidat, Mariam, additional, Mohammad, Mona, additional, Jaradat, Imad, additional, Halalsheh, Hadeel, additional, Alni’mat, Ayat, additional, Ahmad, Danah Kanj, additional, Alsaket, Nour, additional, Mehyar, Mustafa, additional, Al-Nawaiseh, Ibrahim, additional, and Yousef, Yacoub A., additional

Published
2023
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19. Reply

Author

Finger, Paul T., primary, Tomar, Ankit S., additional, Gallie, Brenda, additional, Kivelä, Tero T., additional, Mallipatna, Ashwin, additional, Zhang, Chengyue, additional, Zhao, Junyang, additional, Wilson, Matthew W., additional, Brennan, Rachel C., additional, Burges, Michala, additional, Kim, Jonathan, additional, Berry, Jesse L., additional, Jubran, Rima, additional, Khetan, Vikas, additional, Ganesan, Suganeswari, additional, Yarovoy, Andrey, additional, Yarovaya, Vera, additional, Kotova, Elena, additional, Volodin, Denis, additional, Yousef, Yacoub A., additional, Nummi, Kalle, additional, Ushakova, Tatiana L., additional, Yugay, Olga V., additional, Polyakov, Vladimir G., additional, Ramirez-Ortiz, Marco A., additional, Esparza-Aguiar, Elizabeth, additional, Chantada, Guillermo, additional, Schaiquevich, Paula, additional, Fandino, Adriana, additional, Yam, Jason C., additional, Lau, Winnie W., additional, Lam, Carol P., additional, Sharwood, Phillipa, additional, Moorthy, Sonia, additional, Long, Quah Boon, additional, Essuman, Vera Adobea, additional, Renner, Lorna A., additional, Semenova, Ekaterina, additional, Català-Mora, Jaume, additional, Correa-Llano, Genoveva, additional, and Carreras, Elisa, additional

Published
2023
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22. SIOP PODC–adapted treatment guidelines for craniopharyngioma in low‐ and middle‐income settings.

Author

Amayiri, Nisreen, Spitaels, Ariane, Zaghloul, Mohamed, Figaji, Anthony, Cavalheiro, Sergio, Muller, Hermann L., Elhassan, Moawia, Parkes, Jeannette, Mushtaq, Naureen, Beltagy, Mohamed El, Yousef, Yacoub A., Esiashvili, Natia, Sullivan, Michael, da Costa, Marcos Devanir, Dastoli, Patricia, Mubarak, Fatima, Bartels, Ute, Chamdine, Omar, Davidson, Alan, and Musharbash, Awni

Published
2023
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24. Presentation and management outcomes of Retinoblastoma among Syrian refugees in Jordan

Author

Yousef, Yacoub A., primary, Abu Salim, Qusai F., additional, Mohammad, Mona, additional, Jaradat, Imad, additional, Mehyar, Mustafa, additional, AlJabari, Reem, additional, Al-Habahbeh, Omar, additional, Saboubeh, Khalid, additional, Halalsheh, Hadeel, additional, Khzouz, Jakub, additional, Shawagfeh, Munir, additional, Sultan, Iyad, additional, AlMasri, Mahmoud, additional, Al-Nawaiseh, Ibrahim, additional, Al-Hussaini, Maysa, additional, and Mansour, Asem, additional

Published
2023
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26. Feasibility of treating pediatric intracranial germ cell tumors in a middle‐income country: The Jordanian experience

Author

Amayiri, Nisreen, primary, Sarhan, Nasim, additional, Yousef, Yacoub, additional, Ibrahimi, Ahmed Kh., additional, Abu‐Shanab, Sobuh, additional, Al‐Zebin, Zebin, additional, Al‐Hussaini, Maysa, additional, Musharbash, Awni, additional, Tawalbeh, Ahmed, additional, Bouffet, Eric, additional, and Bartels, Ute, additional

Published
2022
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28. Metastatic esophageal carcinoma to the eye masquerading as inflammatory vitreo-retinitis: A case report and literature review.

Author

Shehada, Reham, Turfa, Rim, Ibrahimi, Ahmad K. H., Khzouz, Jakub, Gharaibeh, Azza, Yousef, Yacoub A., and Mohammad, Mona

Abstract

We report an unusual case of metastatic esophageal carcinoma to the vitreous associated with focal retinitis in a 44-year-old male. A 44-year-old male patient, known case of locally advanced esophageal carcinoma, presented with a 3-day history of left eye floaters. The initial diagnosis was inflammatory vitreo-retinitis that responded to systemic steroids. Four months later, the patient presented with relapsed intraocular inflammation, vitreous biopsy using a 25G needle was performed, and cytology confirmed the presence of metastatic carcinoma consistent with his primary esophageal cancer. The patient received external beam radiotherapy to his ocular and brain metastasis, and his eye examination was stable. Five months later, the patient passed away due to progressive brain metastasis. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Stress Management professional with school administrations from its point of view

Author

M. Dr. Yousef Yacoub Shehata and M. Dr. Taghreed Rachid Kazem

Subjects
Social sciences (General), H1-99
Abstract

The problem with research in the lack of research on the subject of professional pressures in educational institutions management, and try to identify the nature of the work management pressures, which came from the sense of the researchers during their work in middle and junior high schools affiliated to the Directorate General of Education Baghdad Karkh first affiliated to the Ministry of Education the field of research born need to know the reasons for the professional pressures, diagnosis, treatment and ways of facing professional pressures because of their effect on the performance of the educational institution and the effectiveness and success of individuals. • The first goal: to identify the nature of occupational stress among middle and junior high school principals from their point of view management. As the results came in favor of the sample any and having a professional pressures and degree is very high, and attributed the researchers to display middle and junior high school principals to considerable pressure from several multiple sources, whether from supervision, or parents, or from an organizational point of frequent burdens resulting from daily work 2. The second objective: Are there significant differences in the nature of professional pressures prevailing in middle and junior high schools, the Department of differences to the General Directorate for Educational Baghdad Kerch first variable depending on sex, years of service, and the results showed that the differences are not statistically significant. The similarity of the circumstances of the regulatory environment and internal and external laws and regulations, instructions and various years of service and agent of equality.

Published
2017
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31. Metastatic Death Based on Presenting Features and Treatment for Advanced Intraocular Retinoblastoma

Author

Tomar, Ankit Singh, primary, Finger, Paul T., additional, Gallie, Brenda, additional, Kivelä, Tero T., additional, Mallipatna, Ashwin, additional, Zhang, Chengyue, additional, Zhao, Junyang, additional, Wilson, Matthew W., additional, Brennan, Rachel C., additional, Burges, Michala, additional, Kim, Jonathan, additional, Berry, Jesse L., additional, Jubran, Rima, additional, Khetan, Vikas, additional, Ganesan, Suganeswari, additional, Yarovoy, Andrey, additional, Yarovaya, Vera, additional, Kotova, Elena, additional, Volodin, Denis, additional, Yousef, Yacoub A., additional, Nummi, Kalle, additional, Ushakova, Tatiana L., additional, Yugay, Olga V., additional, Polyakov, Vladimir G., additional, Ramirez-Ortiz, Marco A., additional, Esparza-Aguiar, Elizabeth, additional, Chantada, Guillermo, additional, Schaiquevich, Paula, additional, Fandino, Adriana, additional, Yam, Jason C., additional, Lau, Winnie W., additional, Lam, Carol P., additional, Sharwood, Phillipa, additional, Moorthy, Sonia, additional, Long, Quah Boon, additional, Essuman, Vera Adobea, additional, Renner, Lorna A., additional, Semenova, Ekaterina, additional, Català-Mora, Jaume, additional, Correa-Llano, Genoveva, additional, and Carreras, Elisa, additional

Published
2022
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32. High-risk Pathologic Features Based on Presenting Findings in Advanced Intraocular Retinoblastoma

Author

Tomar, Ankit Singh, primary, Finger, Paul T., additional, Gallie, Brenda, additional, Kivelä, Tero T., additional, Mallipatna, Ashwin, additional, Zhang, Chengyue, additional, Zhao, Junyang, additional, Wilson, Matthew W., additional, Brennan, Rachel C., additional, Burges, Michala, additional, Kim, Jonathan, additional, Berry, Jesse L., additional, Jubran, Rima, additional, Khetan, Vikas, additional, Ganesan, Suganeswari, additional, Yarovoy, Andrey, additional, Yarovaya, Vera, additional, Kotova, Elena, additional, Volodin, Denis, additional, Yousef, Yacoub A., additional, Nummi, Kalle, additional, Ushakova, Tatiana L., additional, Yugay, Olga V., additional, Polyakov, Vladimir G., additional, Ramirez-Ortiz, Marco A., additional, Esparza-Aguiar, Elizabeth, additional, Chantada, Guillermo, additional, Schaiquevich, Paula, additional, Fandino, Adriana, additional, Yam, Jason C., additional, Lau, Winnie W., additional, Lam, Carol P., additional, Sharwood, Phillipa, additional, Moorthy, Sonia, additional, Long, Quah Boon, additional, Essuman, Vera Adobea, additional, Renner, Lorna A., additional, Semenova, Ekaterina, additional, Català-Mora, Jaume, additional, Correa-Llano, Genoveva, additional, and Carreras, Elisa, additional

Published
2022
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34. Imaging of Uveal Melanoma—Current Standard and Methods in Development

Author

Solnik, Małgorzata, primary, Paduszyńska, Natalia, additional, Czarnecka, Anna M., additional, Synoradzki, Kamil J., additional, Yousef, Yacoub A., additional, Chorągiewicz, Tomasz, additional, Rejdak, Robert, additional, Toro, Mario Damiano, additional, Zweifel, Sandrine, additional, Dyndor, Katarzyna, additional, and Fiedorowicz, Michał, additional

Published
2022
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37. Improving Medical Students’ Awareness About Retinoblastoma: A Practical Strategy

Author

Elfalah,Mutasem, AlNawaiseh,Tamara, Atoum,Dima, AlKhassawneh,Ahmad, Mohammad,Mona, AlNawaiseh,Ibrahim, Yousef,Yacoub A, Elfalah,Mutasem, AlNawaiseh,Tamara, Atoum,Dima, AlKhassawneh,Ahmad, Mohammad,Mona, AlNawaiseh,Ibrahim, and Yousef,Yacoub A

Abstract

Mutasem Elfalah,1 Tamara AlNawaiseh,1 Dima Atoum,2 Ahmad AlKhassawneh,2 Mona Mohammad,3 Ibrahim AlNawaiseh,3 Yacoub A Yousef3 1School of Medicine, The University of Jordan, Amman, Jordan; 2School of Medicine, AlYarmouk University, Irbid, Jordan; 3Department of Surgery (Ophthalmology), King Hussein Cancer Center, Amman, JordanCorrespondence: Yacoub A Yousef, Department of Surgery (Ophthalmology), King Hussein Cancer Center, Queen Rania Al-Abdullah Street, P.O Box 1269, Amman, 11941, Jordan, Tel +00962787228749, Email yyousef@khcc.joBackground: Eye salvage and survival for patients with retinoblastoma (RB) can be improved by enhancement of early diagnosis. This study aims to investigate the impact of modifying the teaching curriculum for medical students about awareness of this condition.Methods: Medical students completed a questionnaire about RB, preluded by a photograph of a child with leukocoria. Participants were divided into group A (138 participants) and group B (151 participants) who are medical students who have completed the ophthalmology rotation before and after implementing modifications on teaching curriculum that focuses on the red flags of RB consecutively.Results: Most participants considered leukocoria an abnormal sign. Group A had significantly lower knowledge about diagnosis for RB (P=0.0001). Participants scored higher in group B for the critical questions, such as knowing that RB is a fatal disease (P=0.041) that needs urgent treatment (P=0.042). Only three (2%) students adopted the “watch and wait” strategy in group B, compared to 16 (12%) in group A (P=0.0013). Overall, proficiency score (≥ 90%) was achieved by 12 (8%) students in group B, but only three (2%) students in group A. Only 41 (27%) students in group B, compared to 90 (65%) students in group A, failed to obtain a sufficiency score (≥ 70%) in the questionnaire.Conclusion: Modifying the teaching curriculum of the ophthalmology rotation with an intensified focus on awareness of

Published
2022

38. Visual Outcome for Children with Optic Pathway Gliomas Treated with Systemic Chemotherapy

Author

Mohammad,Mona, Alrawashdeh,Hamzeh Mohammad, Mehyar,Mustafa, Amayiri,Nisreen, Abu Laban,Dima, Alnawaiseh,Ibrahim, Yousef,Yacoub, Mohammad,Mona, Alrawashdeh,Hamzeh Mohammad, Mehyar,Mustafa, Amayiri,Nisreen, Abu Laban,Dima, Alnawaiseh,Ibrahim, and Yousef,Yacoub

Abstract

Mona Mohammad,1,&ast; Hamzeh Mohammad Alrawashdeh,2,&ast; Mustafa Mehyar,1 Nisreen Amayiri,3 Dima Abu Laban,4 Ibrahim Alnawaiseh,1 Yacoub Yousef1 1Department of Surgery, Division of Ophthalmology, King Hussein Cancer Center (KHCC), Amman, Jordan; 2Department of Ophthalmology, Sharif Eye Centers, Irbid, Jordan; 3Department of Pediatric Oncology, King Hussein Cancer Center (KHCC), Amman, Jordan; 4Department of Diagnostic Radiology, King Hussein Cancer Center (KHCC), Amman, Jordan&ast;These authors contributed equally to this workCorrespondence: Mona Mohammad; Yacoub Yousef, Department of Surgery, Division of Ophthalmology, King Hussein Cancer Center, P.O. Box 1269, Amman, 11941, Jordan, Tel +962 795372321 ; +962 79 100 3333, Fax +962 6 5345 567, Email Dm.11804@khcc.jo; yyousef@Khcc.joPurpose: This study aims to report visual acuity outcomes for patients with optic pathway gliomas (OPG) treated with systemic chemotherapy and analyze the associated factors.Patients and Methods: A retrospective study of 29 children with OPG treated with chemotherapy at King Hussein Cancer Center (KHCC), Amman, Jordan, between May/2005 and August/2020. Details on patient demographics, tumor location, systemic chemotherapy, and progression of disease were extracted from medical records.Results: Fifty-four eyes of twenty-nine patients were included in this study with a follow-up range from 2 to 17 years. Sixteen patients (55%) had a history of neurofibromatosis-1 (NF1). Most of the eyes (31, 57%) had visual acuity ranges in the moderate or better group. The age group ≥ 5 years at diagnosis, those with hydrocephalus, and patients with non-NF1 presented the worst visual acuity ranges from severe or worse; the p-value was 0.043, 0.0320, and 0.0054, respectively. Following treatment with systemic chemotherapy, visual acuity improved in 5 (17%) patients, remained the same in 23 (79%) patients, and only one patient (3%) had vision deterioration. Of the five patients who showed visio

Published
2022

39. Ultrasound Biomicroscopy Measurements of the Normal Thickness for the Ciliary Body and the Iris in a Middle East Population

Author

Yousef,Yacoub A, Mohammad,Mona, AlNawaiseh,Ibrahim, AlJabari,Reem, Toro,Mario Damiano, Gharaibeh,Almutez, Rejdak,Robert, Nowomiejska,Katarzyna, Zweifel,Sandrine, Avitabile,Teresio, Rejdak,Magdalena, Nazzal,Rashed, Yousef,Yacoub A, Mohammad,Mona, AlNawaiseh,Ibrahim, AlJabari,Reem, Toro,Mario Damiano, Gharaibeh,Almutez, Rejdak,Robert, Nowomiejska,Katarzyna, Zweifel,Sandrine, Avitabile,Teresio, Rejdak,Magdalena, and Nazzal,Rashed

Abstract

Yacoub A Yousef,1 Mona Mohammad,1 Ibrahim AlNawaiseh,1 Reem AlJabari,1 Mario Damiano Toro,2,3 Almutez Gharaibeh,4 Robert Rejdak,5 Katarzyna Nowomiejska,5 Sandrine Zweifel,3 Teresio Avitabile,6 Magdalena Rejdak,6 Rashed Nazzal2 1Department of Surgery (Ophthalmology), King Hussein Cancer Centre, Amman, Jordan; 2Faculty of Medical Sciences, Collegium Medicum, Cardinal Stefan Wyszy&nacute;ski University, Warsaw, Poland; 3Department of Ophthalmology, University of Zürich, Zürich, Switzerland; 4School of Medicine, The University of Jordan, Amman, Jordan; 5Department of General Ophthalmology, Medical University of Lublin, Lublin, Poland; 6Department of Ophthalmology, University of Catania, Catania, ItalyCorrespondence: Yacoub A YousefDepartment of Surgery (Ophthalmology), King Hussein Cancer Centre, Queen Rania St, Amman, 11941, JordanTel +96265355000Email yyousef@khcc.joMario Damiano ToroDepartment of Ophthalmology, University Hospital of Zürich, Raemistrasse 100, Zürich, 8091, SwitzerlandTel +39 3495158220Email toro.mario@email.itPurpose: Ciliary body (CB) and iris thicknesses may change with certain eye diseases as well as between different populations. Here, we report Ultrasound Biomicroscopy Measurements (UBM) of the normal thickness for the CB and the iris from a homogenous population in the Middle East.Patients and Methods: Sonomed 35-MHz (SONOMED, INC. New York, USA) images were obtained at 4 radial meridians, and the thickness was measured at 3 locations along the radial length of the iris and at the thickest part of the CB. Parameters included mean thickness, median thickness, range, and standard deviation.Results: Of 46 adult patients, 83 normal eyes were included in this analysis. The overall mean, median iris thicknesses at the iris root, midway along the radial length of the iris, and at the juxtapupillary margin in mm were 0.42, 0.41 ± 0.08, 0.52, 0.51± 0.08, and 0.72, 0.71± 0.1, respectively. The overall mean, median thicknesses of the CB and CB

Published
2022

40. Retinoblastoma and uveal melanoma in Jordan: incidence, demographics, and survival (2011-2020).

Author

Yousef, Yacoub A., Mohammad, Mona, Al-Nawaiseh, Ibrahim, Mahafza, Hala, Halalsheh, Hadeel, Mehyar, Mustafa, AlJabari, Reem, Al-Rawashdeh, Khaleel, Jaradat, Imad, Sultan, Iyad, and Al-Hussaini, Maysa

Subjects
*RETINOBLASTOMA, *GENETIC disorders, *MELANOMA, *SURVIVAL rate, WESTERN countries
Abstract

We present an epidemiologic analysis of retinoblastoma (RB) and uveal melanoma (UM) in Jordan to aid national strategies for improved ocular cancer surveillance and control. A retrospective cohort of all Jordanian patients with RB and UM diagnosed over 10 years (2011–2020). Outcome measures included incidence, demographics, and outcomes. Retinoblastoma (n = 124) was more common than UM (n = 82); there was no sex predilection for either group. The median age at diagnosis of RB was 15 months(Six and 28 months for bilateral and unilateral cases, respectively), and the mean age-adjusted incidence was 8.2 cases per-million-children per year for children aged five years or less(one per 15,620 newborn per year). Fifty-one(41%) had bilateral disease, and 18(15%) had familial disease. Ninety-six(55%) eyes were group D or E(78% were T3/T4), and the five-year survival rate was 96%. For UM, the median age at diagnosis was 45 years with an incidence of 1.39 new cases per year per one million population. All(100%) had nonfamilial unilateral disease. Seventy-three(89%) had the tumor in the choroid, and 48(58%) had an advanced tumor that had invaded the sclera or the orbit (T3/T4) tumor. Sixty-two(76%) were treated by I-125 radioactive plaque, with globe salvage in 59(95%); the five-year survival rate was 85%. In Jordan, RB is more common and has better survival than UM. RB in Jordan and Western countries is equal in terms of incidence, globe salvage, and survival. UM is less common, with lower age at diagnosis (that was associated with better survival) in Jordan than in Western countries. [ABSTRACT FROM AUTHOR]

Published
2023
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46. A Proposal for Future Modifications on Clinical TNM Staging System of Retinoblastoma Based on the American Joint Committee on Cancer Staging Manual, 7th and 8th Editions

Author

Yousef, Yacoub A., primary, Qaddoumi, Ibrahim, additional, Al-Nawaiseh, Ibrahim, additional, Mohammad, Mona, additional, AlRimawi, Dalia, additional, Toro, Mario Damiano, additional, Zweifel, Sandrine, additional, Rejdak, Robert, additional, Nazzal, Rashed, additional, Mehyar, Mustafa, additional, Jaradat, Imad, additional, Sultan, Iyad, additional, and Al-Hussaini, Maysa, additional

Published
2022
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47. Ultrasound Biomicroscopy Measurements of the Normal Thickness for the Ciliary Body and the Iris in a Middle East Population

Author

Yousef, Yacoub A, primary, Mohammad, Mona, additional, AlNawaiseh, Ibrahim, additional, AlJabari, Reem, additional, Toro, Mario Damiano, additional, Gharaibeh, Almutez, additional, Rejdak, Robert, additional, Nowomiejska, Katarzyna, additional, Zweifel, Sandrine, additional, Avitabile, Teresio, additional, Rejdak, Magdalena, additional, and Nazzal, Rashed, additional

Published
2022
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49. Retinoblastoma seeds: impact on American Joint Committee on Cancer clinical staging.

Author

Tomar, Ankit Singh, Finger, Paul T., Gallie, Brenda, Kivelä, Tero, Mallipatna, Ashwin, Chengyue Zhang, Junyang Zhao, Wilson, Matthew, Brennan, Rachel, Burges, Michala, Kim, Jonathan, Berry, Jesse L., Jubran, Rima, Khetan, Vikas, Ganeshan, Suganeswari, Yarovoy, Andrey, Yarovaya, Vera, Kotova, Elena, Volodin, Denis, and Yousef, Yacoub

Abstract

Aim To investigate whether the American Joint Committee on Cancer (AJCC) clinical category cT2b needs to be subclassified by the type and distribution of retinoblastoma (RB) seeding. Methods Multicentre, international registry-based data were collected from RB centres enrolled between January 2001 and December 2013. 1054 RB eyes with vitreous or subretinal seeds from 18 ophthalmic oncology centres, in 13 countries within six continents were analysed. Local treatment failure was defined as the use of secondary enucleation or external beam radiation therapy (EBRT) and was estimated with the Kaplan-Meier method. Results Clinical category cT2b included 1054 eyes. Median age at presentation was 16.0 months. Of these, 428 (40.6%) eyes were salvaged, and 430 (40.8%) were treated with primary and 196 (18.6%) with secondary enucleation. Of the 592 eyes that had complete data for globe salvage analysis, the distribution of seeds was focal in 143 (24.2%) and diffuse in 449 (75.8%). The 5-year Kaplan-Meier cumulative globe- salvage (without EBRT) was 78% and 49% for eyes with focal and diffuse RB seeding, respectively. Cox proportional hazards regression analysis confirmed a higher local treatment failure risk with diffuse seeds as compared with focal seeds (hazard rate: 2.8; p<0.001). There was insufficient evidence to prove or disprove an association between vitreous seed type and local treatment failure risk(p=0.06). Conclusion This international, multicentre, registrybased analysis of RB eyes affirmed that eyes with diffuse intraocular distribution of RB seeds at diagnosis had a higher risk of local treatment failure when compared with focal seeds. Subclassification of AJCC RB category cT2b into focal vs diffuse seeds will improve prognostication for eye salvage. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Metastatic unilateral retinoblastoma to the contralateral orbital optic nerve presenting with optic disc edema.

Author

Laban, Dima Abu, Al-Hussaini, Maysa, AlJabari, Reem, Mohammad, Mona, Deebajah, Rasha, and Yousef, Yacoub A.

Subjects
RETINAL detachment, OPTIC nerve, EDEMA, RETINAL diseases, OCULAR tumors, MAGNETIC resonance imaging, RETINOBLASTOMA, METASTASIS, ORBITAL diseases, MUSCLE weakness, OPTIC neuritis, ENUCLEATION of the eye, BLINDNESS, CEREBROSPINAL fluid
Abstract

Retinoblastoma (Rb) is a malignant eye tumor that poses a significant risk of mortality once metastasized. We present the case of a 30-month-old girl with left-sided Rb who underwent primary enucleation with pathology-confirmed diagnosis without high-risk pathologic features. Therefore she did not receive adjuvant chemotherapy. Six months later, the patient developed skull bone and bone marrow metastasis, which were treated with systemic chemotherapy, excision of bone metastasis, focal radiation treatment to the site of osseous metastasis, and bone marrow transplantation. Follow-up for two years was unremarkable until she presented with vision loss in the remaining contralateral eye. Ophthalmic examination revealed severe optic disc edema without intraocular masses, initially thought to be optic neuritis. However, the patient did not respond to steroids, and the initial cerebrospinal fluid (CSF) analysis was negative. This was repeated based on high clinical suspicion of metastasis, revealing only a few malignant cells. The presentation and appearance of the optic nerve were considered metastasis-related and treated with radiation therapy, which resulted in dramatic clinical and radiological improvement. Unfortunately, a few weeks later, the patient developed lower limb weakness, and imaging showed diffuse leptomeningeal metastasis, confirmed by CSF findings. This case represents the first documented isolated contralateral optic nerve metastasis in Rb. [ABSTRACT FROM AUTHOR]

Published
2023
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