58 results on '"Young D. Kim"'
Search Results
2. Development of Inertial Measurement Sensor Using Magnetic Levitation
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Dae W. Lee, Young D. Kim, and Kyeum R. Cho
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Engineering ,Inertial frame of reference ,business.industry ,Inertial reference unit ,Control engineering ,Gyroscope ,Accelerometer ,law.invention ,Computer Science::Robotics ,Inertial measurement unit ,law ,Position (vector) ,business ,Inertial navigation system ,Simulation ,Magnetic levitation - Abstract
An INS(Inertial Navigation System) is composed of a navigation computer and an IMU(Inertial Measurement Unit), and can be applied to estimate a vehicle's state. But the inertial sensors assembled in the IMU are too complicated and expensive to use for the general application purpose. In this study, a new concept of inertial sensor system using magnetic levitation is proposed. The proposed system is expected to replace one single-axis rate or position gyroscope, and one single-axis accelerometer concurrently with a relatively simple structure. A simulation of the proposed system is given to describe the capability of this new concept.
- Published
- 2005
3. Estradiol prevents homocysteine-induced endothelial injury in male rats
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Alfonso M. Pacquing, Kamellia R. Dimitrova, Johan P. Suyderhoud, Kerry W. DeGroot, Adam K. Myers, Thomas J. Munro, Jacqueline Wieneke, Young D. Kim, and Eugen A. Pirovic
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Male ,medicine.medical_specialty ,Hyperhomocysteinemia ,Antioxidant ,Endothelium ,Homocysteine ,Arteriosclerosis ,Physiology ,medicine.drug_class ,medicine.medical_treatment ,Glucosephosphate Dehydrogenase ,In Vitro Techniques ,Antioxidants ,chemistry.chemical_compound ,Physiology (medical) ,Internal medicine ,medicine.artery ,medicine ,Animals ,Rats, Wistar ,Aorta ,Ultrasonography ,Estradiol ,Chemistry ,Myocardium ,Hydrogen Peroxide ,Glutathione ,medicine.disease ,Acetylcholine ,Rats ,medicine.anatomical_structure ,Endocrinology ,Estrogen ,Endothelium, Vascular ,Cardiology and Cardiovascular Medicine ,medicine.drug - Abstract
We investigated whether estradiol may prevent accelerated atherosclerosis due to hyperhomocysteinemia by enhancing the antioxidant system.Male Wistar rats were treated with placebo (P) or 1 mg (1E2) and 2 mg (2E2) 17 beta estradiol. Half of the animals (n=6) from each group received homocysteine (Hcy, 100 mg/kg/day) administered in the drinking water for 60 days (P/Hcy, 1E2/Hcy and 2E2/Hcy). Glutathione (GSH) content and glucose-6-phosphate dehydrogenase (G6PDH) activity were determined in myocardial tissues, as well as the serum Hcy concentrations and blood levels of hydrogen peroxide (H(2)O(2)). The relaxation response of aortic ring segments to acetylcholine (ACh) was used for the assessment of endothelial function, and hematoxylin-eosin stained thin sections of rat aorta were used for detection of the histological changes (namely endothelial damage and wall thickening).Depression of relaxation to ACh occurred in P/Hcy compared to P (15.7 +/- 4% vs. 96.3 +/- 7%, P0.0001), but estrogen significantly restored endothelium dependent relaxation in hyperhomocysteinemic rats (86.8 +/- 9.3%, P0.001). Histological examination revealed aortic endothelial denudation in P/Hcy while the endothelial structures of the aorta from the 1E2/Hcy and 2E2/Hcy appeared normal. Significant reductions in GSH and G6PDH levels were detected in P/Hcy (1.5 +/- 0.01 micromol/g and 3.21 +/- 1.2 U/mg, respectively) compared to 1E2/Hcy (2.5 +/- 0.3 micromol/g and 12.81 +/- 1.5 U/mg, P0.001) and 2E2/Hcy (3.11 +/- 1.1 micromol/g and 15.66 +/- 4 U/mg, P0.001). In addition, blood H(2)O(2) level in 1E2/Hcy and 2E2/Hcy remained low while it was raised significantly in P/Hcy compared to P (P0.001).These data suggest that the observed reduction of GSH levels and suppression of G6PDH activity induced by Hcy coupled, with endothelial ultrastructural changes and impaired function, all reversed by estradiol, may have relevance to the mechanisms of atherogenesis and the beneficial effects of estrogen replacement therapy.
- Published
- 2002
4. Benefits of prophylactic continuous infusion of furosemide after the maze procedure for atrial fibrillation
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Kerry W. DeGroot, Henry C. Lue, James L. Cox, Johan P. Suyderhoud, Weijia Z. Duvall, Niv Ad, Young D. Kim, Martin A. Makary, and Eugen A. Pirovic
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_treatment ,Hemodynamics ,Pulmonary Edema ,Urine ,Postoperative Complications ,Bolus (medicine) ,Furosemide ,Edema ,Atrial Fibrillation ,medicine ,Humans ,Diuretics ,Infusions, Intravenous ,Chemotherapy ,business.industry ,Atrial fibrillation ,Middle Aged ,Water-Electrolyte Balance ,medicine.disease ,Pleural Effusion ,Case-Control Studies ,Anesthesia ,Female ,Surgery ,Diuretic ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Complication ,medicine.drug - Abstract
Objectives: One of the most significant complications seen after the maze procedure for atrial fibrillation is excessive fluid retention, with subsequent pulmonary complications. To address this problem we recently started treating all patients prophylactically with a continuous infusion of furosemide starting immediately after the operation. Methods: Seventy-five consecutive patients with statistically similar demographic characteristics were divided into two groups. In the continuous infusion group (n = 36) furosemide was given intravenously as a continuous infusion at a dose of 2 to 15 mg/h for the first 48 hours after the operation, and in the bolus dose group (n = 39) furosemide was administered in bolus doses (50-100 mg) to maintain a targeted daily urinary output of 25 to 50 mL/kg. Hemodynamic data, urinary output, fluid balance, daily weights, and pulmonary complications were recorded during the first 48 hours after the operation. Results: The mean postoperative urinary output was higher, the total furosemide dose was lower, and the pulmonary complications were fewer in the continuous infusion group than in the bolus dose group. Three patients in the bolus dose group were reintubated after the operation, whereas none in the continuous infusion group were reintubated. Supplemental oxygen requirements were greater in the bolus dose group (7 vs 4 patients, P < .05). In the bolus dose group, 4 patients (10%) required thoracentesis and 3 patients (8%) required chest tube insertions for postoperative pleural effusions, in contrast with 1 patient (3%) each in the continuous infusion group (P < .05). Conclusion: Despite a smaller total dose relative to bolus infusion, prophylactic continuous furosemide infusion decreased the adverse pulmonary complications associated with excessive fluid retention in patients undergoing the maze procedure for atrial fibrillation.
- Published
- 2002
5. Actin-Binding Cellular Proteins inside Human Immunodeficiency Virus Type 1
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Young D. Kim, Xiao Zhen Zhou, Raymond C. Sowder, Kun Ping Lu, Lori V. Coren, David E. Ott, Louis E. Henderson, Robert J. Fisher, Donald G. Johnson, and Bradley P. Kane
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medicine.medical_treatment ,Immunoblotting ,Molecular Sequence Data ,Phosphatidylethanolamine Binding Protein ,Androgen-Binding Protein ,03 medical and health sciences ,Non-histone protein ,Peptide Elongation Factor 1 ,HIV Protease ,Sequence Analysis, Protein ,Virology ,medicine ,Humans ,Actin-binding protein ,Amino Acid Sequence ,Phospholipid Transfer Proteins ,Peptide sequence ,Polyacrylamide gel electrophoresis ,Actin ,Chromatography, High Pressure Liquid ,030304 developmental biology ,Adaptor Proteins, Signal Transducing ,Monomeric GTP-Binding Proteins ,0303 health sciences ,Protease ,biology ,030302 biochemistry & molecular biology ,Microfilament Proteins ,Subtilisin ,Virion ,Signal transducing adaptor protein ,Glyceraldehyde-3-Phosphate Dehydrogenases ,Blood Proteins ,Chaperonin 60 ,NM23 Nucleoside Diphosphate Kinases ,Peptidylprolyl Isomerase ,Actins ,3. Good health ,Cell biology ,NIMA-Interacting Peptidylprolyl Isomerase ,Membrane protein ,Lymphocyte Specific Protein Tyrosine Kinase p56(lck) ,Nucleoside-Diphosphate Kinase ,biology.protein ,HIV-1 ,Electrophoresis, Polyacrylamide Gel ,Carrier Proteins ,Transcription Factors - Abstract
Host proteins are incorporated both on and inside human immunodeficiency virus type 1 (HIV-1) virions. To identify cellular proteins inside HIV-1, virion preparations were treated by a protease-digestion technique that removes external host proteins, allowing for the study of the proteins inside the virus. Treated HIV-1 preparations were analyzed by immunoblot, high-pressure liquid chromatography, and protein sequence analyses. These analyses identified several cellular proteins inside HIV-1: elongation factor 1α, glyceraldehyde-3-phosphate dehydrogenase, HS-1, phosphatidylethanolamine-binding protein, Pin1, Lck, Nm23-H1, and the C-terminal tail of CD43. Several of these proteins were found as fragments of their full-sized proteins that appear to be generated by our protease treatment of the virions, the HIV-1 protease, or a cellular protease. Recent advances in cell biology and biochemistry have identified some of these proteins as actin-binding proteins. These results support the hypothesis that actin filaments are incorporated into the virion and may provide additional clues for the understanding of the interaction between viral and cellular proteins during assembly and budding.
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- 2000
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6. Non-Anticoagulant Heparin Increases Endothelial Nitric Oxide Synthase Activity: Role of Inhibitory Guanine Nucleotide Proteins
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Robert L. Hannan, James V. Sitzmann, Eileen M. Redmond, Paul A. Cahill, Adam K. Myers, Navin K. Kapur, Peter C. Kouretas, Young D. Kim, and Richard J. Hendrickson
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Male ,Time Factors ,Endothelium ,medicine.drug_class ,Blotting, Western ,Aorta, Thoracic ,In Vitro Techniques ,Pharmacology ,Pertussis toxin ,Potassium Chloride ,Nitric oxide ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,GTP-Binding Proteins ,Enos ,medicine ,Citrulline ,Animals ,Virulence Factors, Bordetella ,Endothelial dysfunction ,Molecular Biology ,Cells, Cultured ,Edetic Acid ,Dose-Response Relationship, Drug ,biology ,Heparin ,Anticoagulant ,biology.organism_classification ,medicine.disease ,Acetylcholine ,Rats ,NG-Nitroarginine Methyl Ester ,medicine.anatomical_structure ,Pertussis Toxin ,chemistry ,Biochemistry ,Cattle ,Endothelium, Vascular ,Nitric Oxide Synthase ,Cardiology and Cardiovascular Medicine ,Deoxycholic Acid ,medicine.drug - Abstract
Heparin, which is widely used clinically, has recently been shown to have specific properties affecting the vascular endothelium. We hypothesized that heparin stimulates endothelial nitric oxide synthase (eNOS) activity by a mechanism independent of its anticoagulant properties and dependent on an inhibitory guanine nucleotide regulatory protein (Gi). We determined the effect of both heparin and N-acetyl heparin (Non-Hep), a heparin derivative without anticoagulant properties, on eNOS activity in cultured bovine aortic endothelial cells and on endothelium-dependent relaxation in isolated vascular rings. The eNOS activity was determined by measuring both citrulline and nitric oxide (NO) metabolite formation. Heparin and Non-Hep dose-dependently increased basal eNOS activity (ED50 1.0 microgram/ml or 0.15 U/ml), an effect that was significantly inhibited by pertussis toxin (100 ng/ml), a Gi-protein inhibitor. Agonist-stimulated (acetylcholine, 10 microM) eNOS activity was potentiated following pre-treatment with both heparin and Non-Hep and reversed by pertussis toxin. Heparin and Non-Hep induced a dose-dependent relaxation in preconstricted thoracic aortic rings, an effect that was significantly inhibited by pertussis toxin, endothelial inactivation (following treatment with sodium deoxycholate) and NG-nitro-L-arginine-methyl ester (L-NAME). We conclude that heparin and non-anticoagulant heparin induce endothelium-dependent relaxation following activation of eNOS by a mechanism involving a Gi-protein. Administration of heparin derivatives without anticoagulant properties may have therapeutic implications for the preservation of eNOS in conditions characterized by endothelial dysfunction.
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- 1998
7. Heparin preserves nitric oxide activity in coronary endothelium during ischemia-reperfusion injury
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Irving L. Kron, Lam N. To, Adam K. Myers, Yi Ning Wang, Young D. Kim, Peter C. Kouretas, Robert B. Wallace, Paul A. Cahill, and Robert L. Hannan
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Male ,Pulmonary and Respiratory Medicine ,Time Factors ,Endothelium ,Ischemia ,Myocardial Reperfusion Injury ,Nitric Oxide ,Nitric oxide ,Random Allocation ,chemistry.chemical_compound ,Dogs ,medicine ,Animals ,Endothelial dysfunction ,Cyclic guanosine monophosphate ,Heparin ,business.industry ,Anticoagulants ,medicine.disease ,Coronary Vessels ,Vasodilation ,medicine.anatomical_structure ,chemistry ,Anesthesia ,Cattle ,Surgery ,Endothelium, Vascular ,Cardiology and Cardiovascular Medicine ,business ,Reperfusion injury ,Artery ,medicine.drug - Abstract
Brief episodes of ischemia followed by reperfusion adversely affect endothelial vasomotor function. We hypothesized that heparin may impart a protective effect on the coronary endothelium during ischemia-reperfusion injury possibly via the nitric oxide pathway.Eighteen anesthetized dogs were randomly assigned to one of two treatment groups: saline solution or bovine heparin (6.0 mg x kg intravenously). A flow probe and cannula were placed in the left anterior descending artery. Functional recovery of the coronary endothelium was assessed after 15 minutes of ischemia and during 120 minutes of reperfusion after acetylcholine and nitroprusside challenge. In a separate group (n = 10), nitric oxide activity was measured as nitrate/nitrite levels and cyclic guanosine monophosphate levels in the left anterior descending artery.Control dogs displayed a significant decrease in percent change of left anterior descending artery flow at 15, 30, and 60 minutes of reperfusion (67%+/-8%, 76% +/-11%, and 84%+/-8%) when compared with preischemic values (108+/-6; p0.01). Heparinized dogs, however, showed preservation of coronary endothelial function after acetylcholine challenge throughout reperfusion. Heparin-treated dogs also displayed a significant increase in nitrate/nitrite levels during reperfusion (37.3+/-4.1 micromol/L) when compared with the saline group (24.3+/-0.8 micromol/L; p0.03). Left anterior descending artery levels of cyclic guanosine monophosphate were also significantly increased after heparin administration (3.0+/-0.3 pmol/mg) when compared with ischemia-reperfusion alone (0.7+/-0.1 pmol/mg; p0.03).Heparin preserves the vasoregulatory function of the coronary endothelium during brief episodes of ischemia-reperfusion injury, in part, via the nitric oxide pathway. Administration of heparin may have important therapeutic implications in the prevention of coronary endothelial dysfunction associated with reperfusion injury.
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- 1998
8. 17-β Estradiol Regulation of Myocardial Glutathione and Its Role in Protection Against Myocardial Stunning in Dogs
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Adam K. Myers, Alfonso M. Pacquing, Peter W. Ramwell, David Eric Lees, M Y Farhat, Kerry W. DeGroot, Young D. Kim, Johan P. Suyderhoud, and Peter C. Kouretas
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Male ,medicine.medical_specialty ,Antioxidant ,Systole ,medicine.drug_class ,medicine.medical_treatment ,Ischemia ,Glucosephosphate Dehydrogenase ,Nitric Oxide ,Ventricular Function, Left ,Lipid peroxidation ,chemistry.chemical_compound ,Dogs ,Internal medicine ,medicine ,Animals ,Buthionine sulfoximine ,Rats, Wistar ,Myocardial Stunning ,Pharmacology ,Myocardial stunning ,Estradiol ,business.industry ,Myocardium ,Heart ,Coronary ischemia ,Glutathione ,medicine.disease ,Rats ,Perfusion ,Endocrinology ,chemistry ,Estrogen ,Lipid Peroxidation ,Cardiology and Cardiovascular Medicine ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
We studied the effect of 2-week treatment with estradiol 17beta on myocardial glutathione concentration in dogs and isolated perfused rat heart subjected to brief coronary ischemia and reperfusion. Estradiol protected against ischemia/reperfusion-induced myocardial systolic shortening and malonylaldehyde production and increased myocardial glutathione concentration and glucose-6-phosphate dehydrogenase enzyme activity. Reduction of myocardial glutathione with buthionine sulfoximine to levels seen in the absence of estrogen reversed the protective effect of estradiol against myocardial dysfunction and lipid peroxidation associated with ischemia/reperfusion. These results suggest that the antioxidant effect of estradiol in ischemia/reperfusion may be mediated by regulation of myocardial glutathione metabolism.
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- 1998
9. Safe, Low-technology Anesthesia System for Medical Missions to Remote Locations
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Young D. Kim, H.J. Khambatta, Thomas Flood, Donald N. Westheimer, and Robert W. Power
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Anesthesiology and Pain Medicine ,Anesthesiology ,Medical missions ,business.industry ,Anesthesia ,Humans ,Medicine ,Religious Missions ,Safety ,business ,Developing Countries ,Low technology - Published
- 2006
10. 17β-Estradiol Prevents Dysfunction of Canine Coronary Endothelium and Myocardium and Reperfusion Arrhythmias After Brief Ischemia/Reperfusion
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M Y Farhat, Young D. Kim, David Eric Lees, Peter C. Kouretas, Adam K. Myers, George Thomas, John F. Beauregard, and Barbara Chen
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Male ,Nitroprusside ,Endothelium ,Vasodilator Agents ,Myocardial Ischemia ,Ischemia ,Hemodynamics ,Myocardial Reperfusion Injury ,Vasodilation ,Anterior Descending Coronary Artery ,Dogs ,Coronary Circulation ,Physiology (medical) ,medicine ,Animals ,Endothelial dysfunction ,Estradiol ,biology ,business.industry ,Vascular disease ,Fissipedia ,Arrhythmias, Cardiac ,Heart ,medicine.disease ,biology.organism_classification ,Coronary Vessels ,Myocardial Contraction ,Acetylcholine ,Vasomotor System ,medicine.anatomical_structure ,Anesthesia ,Endothelium, Vascular ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Brief myocardial ischemia is associated with myocardial and coronary endothelial dysfunction caused by oxygen free radicals released during reperfusion. Estrogen, known to have antioxidant activity, may prevent these complications. Methods and Results We assessed the effect of 2 weeks of treatment with 17β-estradiol (E, 100 μg·kg −1 ·d −1 , n=12) or placebo (P, n=15) on myocardial and coronary endothelial function during the first 2 hours of reperfusion in dogs subjected to 15 minutes of ischemia induced by occlusion of the left anterior descending coronary artery (LAD). Our results show that the incidence of ventricular arrhythmias significantly decreased in E (3 of 12) compared with P (11 of 15). Systolic shortening, significantly depressed in P during early reperfusion, was maintained at preischemic levels in E. During reperfusion, the increase in LAD flow to acetylcholine, attenuated in P (60±6%), was preserved in E (151±28%) and was associated with increased serum nitrite/nitrate concentration. n -Pentane in exhaled gas in vivo, an index of lipid peroxidation, increased significantly during early reperfusion in P (from 9.1±1.9 to 41.6±13.0 ppb, P P Conclusions Estrogen protects against endothelial and myocardial dysfunction resulting from brief ischemia/reperfusion. This protection may relate to an antioxidant effect of estrogen.
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- 1996
11. The effect of glucagon on spontaneous contractility of isolated pregnant uterine muscle
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Young K. Shin, Joseph V. Collea, and Young D. Kim
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Adult ,medicine.medical_specialty ,medicine.drug_class ,Muscle Relaxation ,Uterus ,Isometric exercise ,In Vitro Techniques ,Glucagon ,Contractility ,Uterine Contraction ,Pregnancy ,Internal medicine ,medicine ,Humans ,business.industry ,Obstetrics and Gynecology ,Muscle relaxant ,Endocrinology ,medicine.anatomical_structure ,Neuromuscular Agents ,In utero ,Tocolytic ,Sympatholytics ,Female ,medicine.symptom ,business ,Muscle Contraction ,Muscle contraction - Abstract
To determine whether glucagon has relaxant effects on the spontaneous contractions of term pregnant human uterine smooth muscle in an isolated preparation.Myometrial specimens were excised from the upper incisional surface of the lower uterine segment in seven women during elective cesarean delivery. The muscle strips were suspended in tissue baths and isometric tension was recorded. After establishing rhythmic spontaneous contractions, glucagon reconstituted with distilled water or the accompanying diluent was added directly to the bath in a cumulative manner. In the second phase of the study, the effect of the diluent (1.6% glycerin with 0.2% phenol) alone on muscle contractility was evaluated.Glucagon had no effect on uterine muscle concentrations when reconstituted with distilled water. However, glucagon reconstituted with the diluent decreased the contractile amplitude by 27 +/- 11% (mean +/- standard deviation, P.01) and the frequency by 13 +/- 10% (P.05) at a concentration of 20 micrograms/mL. At a cumulative concentration of 40 micrograms/mL, the reductions in amplitude and frequency were 65 +/- 13% (P.001) and 18 +/- 14% (P.01), respectively. The diluent at equivalent concentrations exerted relaxation similar to that produced by glucagon when reconstituted with the diluent. The relaxant effects were not different between the two solutions (P.2, power 90%, alpha = .05).These results suggest that relaxation of contractions was likely caused by the diluent rather than by glucagon. We conclude that glucagon does not have a direct relaxant effect on spontaneous contraction of isolated uterine muscle obtained from term pregnant uteri.
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- 1996
12. Microencapsulation Properties of Gum Arabic and Several Food Proteins: Liquid Orange Oil Emulsion Particles
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Young D. Kim, Charles V. Morr, and Timothy W. Schenz
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General Chemistry ,General Agricultural and Biological Sciences - Published
- 1996
13. ANESTHETIC MANAGEMENT OF PATIENTS UNDERGOING THORACIC AORTIC RECONSTRUCTION
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Young D. Kim and Lisa C. Bachenheimer
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medicine.medical_specialty ,Anesthesiology and Pain Medicine ,business.industry ,Anesthesia ,medicine ,Anesthetic management ,business ,Surgery - Published
- 1995
14. Functional recovery of stunned myocardium is greater with halothane than fentanyl anaesthesia in dogs
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Young D. Kim, Adam K. Myers, A. Analouei, and J.L. White
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Cardiac output ,medicine.medical_specialty ,Myocardial Ischemia ,Heart preservation ,Blood Pressure ,Myocardial Reperfusion ,Anesthesia, General ,Ventricular Function, Left ,Fentanyl ,Contractility ,Coronary circulation ,Dogs ,Reperfusion therapy ,Coronary Circulation ,Internal medicine ,Ventricular Pressure ,medicine ,Animals ,Cardiac Output ,Myocardial Stunning ,Myocardial stunning ,business.industry ,medicine.disease ,Myocardial Contraction ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Anesthesia ,Cardiology ,Halothane ,business ,medicine.drug - Abstract
We have compared the effects of halothane or fentanyl on recovery of regional myocardial function in the postischaemic ventricle in dogs. The animals were followed for 120 min during reperfusion after 15-min of occlusion of the left anterior descending coronary artery. After 120 min of reperfusion, the fentanyl group had recovered only 54% and 50% of regional contractility and systolic shortening (P < 0.05), respectively, compared with halothane (63% and 86%). Intramyocardial tissue pressure was less than baseline 60 min after reperfusion in the fentanyl group (P < 0.05), whereas the halothane group had returned to control values. We conclude that halothane is more effective than fentanyl in attenuating regional myocardial dysfunction associated with transient episodes of ischaemia.
- Published
- 1994
15. Brief ischemia-reperfusion induces stunning of endothelium in canine coronary artery
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Young D. Kim, M Kuwahara, S. Moore, J S Fomsgaard, Peter W. Ramwell, A. Analouei, K F Heim, S S Coughlin, E Kagan, and George Thomas
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Male ,Nitroprusside ,medicine.medical_specialty ,Time Factors ,Endothelium ,Ischemia ,Bradykinin ,Myocardial Reperfusion Injury ,Vasodilation ,Potassium Chloride ,chemistry.chemical_compound ,Dogs ,Physiology (medical) ,Internal medicine ,medicine ,Animals ,business.industry ,Stunning ,Endothelium-derived relaxing factor ,medicine.disease ,Coronary Vessels ,Acetylcholine ,Prostaglandin Endoperoxides, Synthetic ,Vasomotor System ,Coronary arteries ,Microscopy, Electron ,medicine.anatomical_structure ,chemistry ,Cardiology ,Female ,Endothelium, Vascular ,Sodium nitroprusside ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
BACKGROUND Brief ischemic episodes that induce stunning of the myocardium may also induce stunning of the coronary endothelium. To test this hypothesis, we examined both in vivo and in vitro responses of canine coronary arteries exposed to brief ischemia. METHODS AND RESULTS Functional recovery of the endothelium was examined in vivo during reperfusion after 15 minutes of ischemia. Vasodilatory responses to acetylcholine were severely impaired during the first hour of reperfusion but gradually improved over a 90-minute period after ischemia. The vasoconstrictive response to U46619 was enhanced for the first 30 minutes of reperfusion and returned to normal within 60 minutes. In vitro vasomotor responses to potassium chloride, acetylcholine, bradykinin, and sodium nitroprusside were examined in isolated segments of canine coronary arteries preexposed in vivo to brief ischemia (10-30 minutes) and 20 minutes of reperfusion. The results showed enhanced contractile responses and blunted endothelium-dependent but not endothelium-independent vasodilatory responses of arterial rings subjected to 10 minutes of ischemia. Twenty and 30 minutes of ischemia completely impaired endothelium-dependent vasodilation. When reperfusion was extended to 120 minutes after 15 minutes of ischemia, vasodilatory responses to acetylcholine had recovered by almost 90%. Examination of endothelial integrity by transmission electron microscopy after 10-15 minutes of ischemia revealed no evidence of structural damage. Twenty and 30 minutes of ischemia induced cytoplasmic vacuolation, partial detachment of endothelium, and swelling of cytoplasmic organelles. CONCLUSIONS These data support the hypothesis that brief ischemia-reperfusion induces stunning of endothelium in which endothelium-dependent vasodilatory function is impaired temporarily without morphological damage.
- Published
- 1992
16. Pulmonary edema after PGE1 infusion
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Nevin M. Katz, Michael G. Moront, Timothy A. Burke, James Lee White, Young D. Kim, and Neal Fleming
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medicine.medical_specialty ,business.industry ,Hypertension, Pulmonary ,Blood Pressure ,Pulmonary Edema ,Pulmonary edema ,medicine.disease ,Surgery ,Anesthesiology and Pain Medicine ,Anesthesia ,medicine ,Humans ,Female ,Vascular Resistance ,Alprostadil ,Cardiac Output ,Cardiology and Cardiovascular Medicine ,business ,Aged - Published
- 1990
17. Abstract 215: Effect of Adipose Tissue-derived Stromal Cell Transplantation in Mouse Model of Acute Myocardial Infarction
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Long-Hao Yu, Moo H Kim, Dong S Kum, Tae H Park, Kwang S Cha, Young D Kim, Soo Y Seo, and Jin S Jung
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Background: Adipose tissue has been identified as a source of multipotent cells that have the capacity to differentiate into cardiac myocytes, endothelial cells, similar to bone marrow cells. We sought to investigate the effect of adipose tissue-derived stromal cells (ADSCs) therapy on cardiac contractility and remodeling in C57BL/6 mouse model of acute myocardial infarction (AMI). Materials and Methods: Total 30 adult male C58BL/6 mice (12 weeks of age, 28~30g body weight) were used for the study. Mice were randomized into two groups (MI + media, n = 15 and MI + ADSCs, n= 15) after producing AMI by ligation of left anterior descending coronary artery. Intramyocardial injection of 1 × 10 6 ADSCs cells was compared to the injection of media alone. Ten animals were excluded from further analyses because of death. Most of them died 7 to 10 days after AMI, a mouse died duing surgical procedure following LAD ligation. All survived mice (n = 20) were received echocardiograpic analysis before and 2 weeks after cell transplantation, and then sacrificed for histologic analysis. Results: The fractional shortening and left ventricular ejection fraction improved significantly in ADSCs transplant group at 2 weeks compared to control group ( 20.9 ± 3.48% vs 29.9 ± 8.6%, p = 0.006 and 46.4 ± 7.6% vs 63.1 ± 12.8%, p = 0.002 ). Left ventricular end dialstolic dimension in ADSCs transplant group showed a little decrease from 4.65 ± 0.63 mm (control) to 4.14 ± 0.53 mm (ADSC), but there was no statistical difference ( p < 0.072), whereas left ventricle end-systolic diameter decreased significantly in cell transplantation group ( p < 0.05). Also, there were significant difference in injury size, infarct area, wall thickness or scar formation in ADSC group. In histochemical analysis, ADSCs have been shown to migrate into the injured sites and to integrate into the scar areas with some of transplanted ADSCs expressing endothelial marker. Conclusion: ADSCs improved left ventricular function and showed favorable effect on remodeling. They could be a good candidate for the source of cell therapy after myocardial injury.
- Published
- 2007
18. Estrogen and homocysteine
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Adam K. Myers, Young D. Kim, Kerry W. DeGroot, and Kamellia R. Dimitrova
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medicine.medical_specialty ,Homocysteine ,Physiology ,medicine.drug_class ,Breast Neoplasms ,Biology ,medicine.disease_cause ,chemistry.chemical_compound ,Risk Factors ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Coronary atherosclerosis ,Estrogen receptor beta ,Cholesterol ,Estrogens ,Lipids ,Oxidative Stress ,Endocrinology ,chemistry ,Estrogen ,Cardiovascular Diseases ,Uterine Neoplasms ,Female ,Sex ,Endothelium, Vascular ,Cardiology and Cardiovascular Medicine ,Estrogen receptor alpha ,hormones, hormone substitutes, and hormone antagonists ,Oxidative stress ,Hormone - Abstract
Cardiovascular diseases are the major causes of illness and death in women. Premenopausal women are relatively protected from coronary artery disease and atherosclerosis as compared to postmenopausal women, and this protection is attributed to the effects of the female sex hormone (estrogen). The vasculature, like the reproductive tissues, bone, liver, and brain, is now recognized as an important site of estrogen's action. Although estrogen's beneficial effects on the cardiovascular system are well described in many studies, the molecular basis of estrogen protective mechanisms are still quite vague. Both genomic mechanisms, mediated primarily through estrogen receptor alpha (ER alpha) and estrogen receptor beta (ER beta), and non-genomic mechanisms, through nitric oxide (NO), of estrogen action are controversial and do not entirely explain the effects of estrogen on vascular preservation during conditions of oxidative stress. Until recently, the atheroprotective effects of estrogen were attributed principally to its effects on serum lipid concentrations and cholesterol levels. However, two recent reports that estrogen therapy has no effect on the progression of coronary atherosclerosis in women with established disease, despite the favorable changes in LDL and cholesterol levels, leads to questions about the lipid/cholesterol mechanism of estrogen-mediated effects on atherosclerosis. Alternatively, the high level of homocysteine, found to correlate with accelerated cardiovascular disease and identified as an independent risk factor for atherosclerosis, was recently described to be diminished by estrogen. Protection against disturbed sulfhydryl metabolism and higher homocysteine level could be the missing link in understanding how exactly estrogen affects vascular cells metabolism and responses to oxidative stress. This review focuses on estrogen/homocysteine interactions and their relevance to the cardiovascular system.
- Published
- 2002
19. 17-beta estradiol preserves endothelial cell viability in an in vitro model of homocysteine-induced oxidative stress
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Thomas J. Munro, Young D. Kim, Adam K. Myers, Jacqueline Wieneke, Johan P. Suyderhoud, Eugen A. Pirovic, Kamellia R. Dimitrova, and Kerry W. DeGroot
- Subjects
Intracellular Fluid ,medicine.medical_specialty ,Endothelium ,medicine.drug_class ,Cell Survival ,Biology ,medicine.disease_cause ,Antioxidants ,chemistry.chemical_compound ,Internal medicine ,medicine ,Animals ,Buthionine sulfoximine ,Viability assay ,Homocysteine ,Aorta ,Cells, Cultured ,Pharmacology ,Estradiol ,Glutathione ,Hydrogen Peroxide ,Endothelial stem cell ,Oxidative Stress ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Estrogen ,Cattle ,Endothelium, Vascular ,Cardiology and Cardiovascular Medicine ,Oxidative stress ,Intracellular - Abstract
High levels of homocysteine (Hcy) accelerate endothelial cell damage by producing hydrogen peroxide (H(2)O(2)). We investigated whether 17-beta estradiol may prevent the accelerated rate of endothelial cell detachment and reduced cell viability in cultured endothelial cells challenged with Hcy. Cultured bovine aortic endothelial cells (BAEC) were incubated for 72-h with either vehicle (alcohol) or different concentrations of 17-beta estradiol (1 nM [1E2] and 10 nM [10E2]) before being challenged with 0.5 mM of Hcy. Cell viability and H(2)O(2) levels were evaluated at 30 min, 1-, 2-, 4-, 8-, and 24-h after adding Hcy. Cell suspensions were frozen in liquid nitrogen and used later for spectrophotometric measurement of intracellular glutathione (GSH) levels. Cell viability 24 h after Hcy administration was significantly lower in vehicle versus 1 nM and 10 nM 17-beta estradiol (44 +/- 5% vs. 70.66 +/- 4%, [p < 0.001] and 79 +/- 5% respectively, [p < 0.001]). H(2)O(2) levels were higher in vehicle (1 +/- 0.05 microM) compared with 1E2 and 10E2 (0.8 +/- 0.1 microM, p = 0.02 and 0.1 +/- 0.05 microM, respectively, p < 0.001), whereas GSH content was increased in 1E1 and 10E2 versus control (27.69 +/- 4.6 nM/10(6) cells and 43.49 +/- 5.5 nM/10(6) cells vs. 13.33 +/- 1.5 nM/10(6) cells, p < 0.001). Bovine aortic endothelial cells treatment with 17-beta estradiol (0, 1, and 10 nM) and 0.1 mmol buthionine sulfoximine, an inhibitor of gamma-glutamylcysteine synthase, abolished the beneficial effects of estradiol alone on cell viability, GSH content, and H2O2 generation. Estradiol prevents Hcy-induced endothelial cell injury by increasing the intracellular content of GSH.
- Published
- 2002
20. The Maze-III procedure combined with valve surgery
- Author
-
Henry C. Lou, Eugen A. Pirovic, Johann P. Suyderhoud, Young D. Kim, Kerry W. DeGroot, Niv Ad, Terry Palazzo, James L. Cox, Steven Fitzpatrick, and Weiija Z. Duvall
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Valve surgery ,Treatment outcome ,MEDLINE ,Heart Valve Diseases ,Risk Factors ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,cardiovascular diseases ,Cardiac Surgical Procedures ,Survival rate ,Aged ,Retrospective Studies ,Heart Valve Prosthesis Implantation ,business.industry ,valvular heart disease ,Atrial fibrillation ,Retrospective cohort study ,General Medicine ,medicine.disease ,Survival Rate ,Treatment Outcome ,cardiovascular system ,Cardiology ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Abstract
Previous studies have suggested that the Maze procedure is not as effective in controlling atrial fibrillation when the arrhythmia is associated with significant valvular heart disease. In this study, we evaluate our own results in 83 patients who underwent 96 valve procedures in combination with the Maze-III procedure. Our results indicate that the Maze-III procedure is just as safe and effective in controlling atrial fibrillation associated with valvular heart disease as it is in controlling atrial fibrillation not associated with valvular heart disease.
- Published
- 2000
21. Current status of the Maze procedure for the treatment of atrial fibrillation
- Author
-
Young D. Kim, Weiija Z. Duvall, Terry Palazzo, Eugen A. Pirovic, Henry G. Lou, Johann P. Suyderhoud, Steven Fitzpatrick, Niv Ad, Kerry W. DeGroot, and James L. Cox
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Cox maze procedure ,medicine.medical_treatment ,law.invention ,Electrocardiography ,law ,Heart Conduction System ,Heart Rate ,Heart rate ,Atrial Fibrillation ,medicine ,Cardiopulmonary bypass ,Humans ,Minimally Invasive Surgical Procedures ,Heart Atria ,Cardiac Surgical Procedures ,Survival rate ,medicine.diagnostic_test ,business.industry ,Patient Selection ,Atrial fibrillation ,General Medicine ,medicine.disease ,Surgery ,Survival Rate ,Treatment Outcome ,Median sternotomy ,Anesthesia ,Concomitant ,Cardiology and Cardiovascular Medicine ,business - Abstract
Since the first patient underwent the Maze procedure on September 25, 1987, 346 patients have undergone this operation for the treatment of atrial fibrillation. The procedure was designed as an open-heart operation performed through a median sternotomy. It underwent 2 major modifications relatively early in the series, evolving into the so-called Maze-III procedure, which has been used exclusively since April 16, 1992. Since that time, the Maze-III procedure has been adapted to allow it to be done by minimally invasive techniques. In addition, we recently performed the entire procedure in 2 patients without the use of cardiopulmonary bypass. The operative mortality rate has remained at 2% to 3%. This includes patients undergoing concomitant high-risk cardiac surgical procedures and all re-do cases. The overall success rate in curing atrial fibrillation has been 99%. The procedure itself has been shown to cause no permanent damage to the sinus node. The left atrium has been documented to function long-term postoperatively in 93% of patients and the right atrium functions in 99% of patients. The Maze-III procedure remains the surgical procedure of choice for the treatment of medically refractory atrial fibrillation.
- Published
- 2000
22. The effect of propofol on isolated human pregnant uterine muscle
- Author
-
Joseph V. Collea, Young D. Kim, and Young K. Shin
- Subjects
Adult ,medicine.drug_class ,Uterus ,Isometric exercise ,Pregnancy ,Medicine ,Humans ,Propofol ,business.industry ,Myometrium ,Muscle relaxant ,Muscle, Smooth ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,In utero ,Anesthesia ,Gestation ,Female ,medicine.symptom ,business ,Anesthetics, Intravenous ,medicine.drug ,Muscle contraction ,Muscle Contraction - Abstract
Background Propofol is an alternative to thiopental as an intravenous induction agent for cesarean section. Because it has relaxant effects on vascular and other smooth muscles, the authors set out to determine whether propofol has any effect on pregnant human uterine smooth muscle in an isolated preparation. Methods Myometrial specimens were excised from 10 parturients undergoing elective cesarean section. The muscle strips were suspended in tissue baths and isometric tension was recorded. After establishment of rhythmic contractions in the buffer solution as a control, propofol (0.5 to 10 microg/ml) in fat emulsion was applied cumulatively to the bath. The effect of the fat emulsion at equivalent concentrations was also examined. Results Propofol concentrations of 2.7 x 10(-6) M (0.5 microg/ml) and 1.1 x 10(-5) M (2 microg/ml) had no significant effect on the active tension developed by muscle contraction. However, propofol at concentration of 5.5 x 10(-5) M (10 microg/ml) reduced the active tension by 45% (P < 0.02) compared with the control value. The fat emulsion had no effects on the active tension. Conclusions These results imply that the decline in the active tension of muscle contraction was most likely caused by propofol and not by the fat emulsion. However, the propofol concentrations needed to produce a significant reduction in the uterine muscle tension appear to be much greater than the free propofol concentrations reported by others during cesarean section.
- Published
- 1998
23. Heparin and nonanticoagulant heparin preserve regional myocardial contractility after ischemia-reperfusion injury: role of nitric oxide
- Author
-
Adam K. Myers, James V. Sitzmann, Peter C. Kouretas, Jeff L. Myers, Young D. Kim, Yi-Ning Wang, Paul A. Cahill, Robert B. Wallace, and Robert L. Hannan
- Subjects
Pulmonary and Respiratory Medicine ,Male ,Time Factors ,medicine.drug_class ,Ischemia ,Myocardial Reperfusion Injury ,Pharmacology ,Nitric Oxide ,Nitroarginine ,Nitric oxide ,Contractility ,chemistry.chemical_compound ,Dogs ,Guanosine monophosphate ,medicine ,Animals ,Enzyme Inhibitors ,Cyclic guanosine monophosphate ,Cyclic GMP ,business.industry ,Heparin ,Myocardium ,Anticoagulant ,Hemodynamics ,Anticoagulants ,medicine.disease ,Myocardial Contraction ,chemistry ,Anesthesia ,Surgery ,Nitric Oxide Synthase ,Cardiology and Cardiovascular Medicine ,business ,Reperfusion injury ,medicine.drug - Abstract
Objectives: These studies were performed to determine the effect of heparin and nonanticoagulant heparin on myocardial function after ischemia-reperfusion and to further evaluate the role that the nitric oxide–cyclic guanosine monophosphate pathway plays in mediating the effect of heparin. Methods: Fifteen dogs were subjected to 15 minutes ischemia followed by 120 minutes reperfusion and pretreated with either saline solution, bovine heparin (6.0 mg/kg intravenously), or N -acetyl heparin (6.0 mg/kg intravenously), a heparin derivative without anticoagulant properties. The left anterior descending artery was occluded for 15 minutes and regional systolic shortening, a unitless measure of myocardial contractility, assessed during reperfusion. To evaluate the role of nitric oxide, the inhibitor N ω -nitro-l-arginine, 1.5 mg/kg intracoronary, was given before heparin administration. Myocardial levels of cyclic guanosine monophosphate, the second messenger of nitric oxide, were also measured in the N -acetyl heparin group using radioimmunoassay. Results: Regional systolic shortening was significantly decreased in the saline group during 60 and 120 minutes compared with before ischemia (9.2 ± 1.0 and 9.0 ± 0.9 vs 12.2 ± 1.2, p 0.0003). Heparin and N -acetyl heparin–treated dogs, however, showed preservation of systolic shortening throughout reperfusion. Administration of nitro-l-arginine significantly attenuated the protective effect of heparin (9.2 ± 1.2 vs 12.7 ± 1.1, p ≤0.0001) and N -acetyl heparin (9.3 ± 0.3 vs 12.8 ± 0.4, p ≤0.0001) during 120 minutes reperfusion. Myocardial levels of cyclic guanosine monophosphate were also significantly increased in the N -acetyl heparin group compared with saline (199.1 ± 7.1 vs 103.5 ± 4.5 pmol/mg, p ≤0.0001). Conclusions: Heparin preserves myocardial contractility after ischemia-reperfusion independent of its anticoagulant properties. Furthermore, the protective effects of heparin during ischemia-reperfusion are mediated, at least in part, through a nitric oxide–cyclic guanosine monophosphate pathway. (J Thorac Cardiovasc Surg 1998;115:440-9)
- Published
- 1998
24. Effects of isoflurane on regional coronary blood flow and myocardial tissue pressure in chronically instrumented dogs
- Author
-
Kurt Heim, David Eric Lees, Yi-Ning Wang, Young D. Kim, and Adam K. Myers
- Subjects
Male ,medicine.medical_specialty ,Blood Pressure ,Anterior Descending Coronary Artery ,Ventricular Function, Left ,Dogs ,Heart Rate ,Internal medicine ,Coronary Circulation ,Medicine ,Animals ,Isoflurane ,business.industry ,Hemodynamics ,Heart ,Stroke Volume ,Blood flow ,Anesthesiology and Pain Medicine ,Blood pressure ,Regional Blood Flow ,Ventricular pressure ,Cardiology ,Aortic pressure ,Blood Vessels ,Female ,Coronary vasodilator ,business ,Perfusion ,medicine.drug - Abstract
BACKGROUND The effects of isoflurane on distribution of transmural blood flow and transmural intramyocardial tissue pressure (IMP) were studied in chronically instrumented dogs, to address following aims: (1) to evaluate the direct effects of isoflurane on transmural blood flow distribution in the absence of compounding effects of baseline anesthetics, acute surgery, and indirect effects caused by changes in systemic blood pressures and heart rate--factors that were not well controlled in the past studies; (2) to examine the relation between transmural myocardial perfusion pressure and concurrent changes in transmural blood flow distribution during isoflurane anesthesia; and (3) to evaluate the effects of isoflurane on transmural myocardial oxygen supply-demand relation. METHODS Dogs were allowed to recover at least 1 week after surgery for instrumentation. Blood flow of the left anterior descending coronary artery and subendocardial and subepicardial blood flows, regional IMPs, regional segmental dimension, heart rate, aortic pressure and left ventricular pressure were measured while dogs were awake and during 1.3% isoflurane anesthesia, with and without correction of heart rate and aortic pressure. Concurrently regional myocardial perfusion pressure, regional myocardial stroke work, and systolic pressure time index were calculated, based on direct measurements of IMP in subendocardium and subepicardium. RESULTS Without correction of aortic pressure, neither left anterior descending coronary artery flow nor transmural blood flow distribution was altered with isoflurane. When aortic pressure and heart rate were corrected to the awake values, left anterior descending coronary artery flow increased (37 +/- 2%) and the increase was preferentially distributed to subendocardium, resulting in a shift in transmural blood flow. The subendocardial/subepicardial blood flow ratio increased from 1.2 +/- 0.3 to 1.4 +/- 0.4 (p, 0.05). The transmural blood flow changes were closely related to changes in regional myocardial perfusion pressure ratio between subendocardium and subepicardium (r = 0.76, P < 0.001). Concurrent with marked increases in blood flow (55 +/- 4% increase), regional myocardial stroke work and systolic pressure time index of subendocardium were decreased more than 50% with isoflurane, resulting in a favorable subendocardial oxygen supply-demand balance. CONCLUSIONS Isoflurane is a coronary vasodilator and redistributes blood flow in favor of subendocardium and depresses subendocardial work when heart rate and aortic pressure are controlled. These changes in regional myocardial blood flow, regional myocardial stroke work, and systolic pressure time index appear to be a result of changes in regional IMP.
- Published
- 1994
25. Constriction of canine coronary arteries by platelet activating factor after brief ischemia
- Author
-
Adam K. Myers, R.M. Danchak, Young D. Kim, K.F. Heim, and David Eric Lees
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Endothelium ,Ischemia ,Myocardial Ischemia ,Vasodilation ,Blood Pressure ,Biochemistry ,Muscle, Smooth, Vascular ,chemistry.chemical_compound ,Endocrinology ,Dogs ,Heart Rate ,Internal medicine ,Coronary Circulation ,medicine ,Animals ,Platelet Activating Factor ,Platelet-activating factor ,business.industry ,Hemodynamics ,medicine.disease ,Coronary Vessels ,Acetylcholine ,Coronary arteries ,medicine.anatomical_structure ,chemistry ,Regional Blood Flow ,Vasoconstriction ,Circulatory system ,Reperfusion ,cardiovascular system ,Vascular resistance ,Cardiology ,Female ,Vascular Resistance ,medicine.symptom ,business ,circulatory and respiratory physiology - Abstract
Platelet activating factor (PAF) has been suggested as a mediator of coronary spasm and acute myocardial ischemia. However, PAF can have either vasodilator or vasoconstrictor activities according to various reports. Because of the importance of endothelium in regulating vascular tone, we hypothesized that changes in endothelial function could modulate some of the observed differences in the activities of PAF. To test this hypothesis, PAF was infused directly into the left anterior descending coronary artery (LAD) of dogs at a rate of 0.3 microgram/min before and after 20 min of LAD ligation followed by reperfusion. Coronary blood flow (CBF) was measured continuously via a Doppler flow probe. Likewise, responses to the endothelium dependent vasodilator, acetylcholine (ACh) were measured before and after the LAD ligation. Before ligation, PAF produced a vasodilatory response in the LAD, resulting in 28.4 +/- 11.0% increase in CBF and a 21.5 +/- 5.8% decrease in coronary vascular resistance (CVR). However, after ligation and subsequent reperfusion, 0.3 microgram/min PAF produced vasoconstriction, resulting in a 10.2 +/- 8.7% decrease in CBF (p0.01 compared to pre-infusion change in (CBF), and a 27.8 +/- 23.2% increase in CVR (p = 0.05) compared to pre-infusion change in CVR). The vasodilator response to ACh was markedly blunted by ischemia. These results suggest that the coronary vascular response to PAF may depend upon the functional integrity of the endothelium, with endothelial damage resulting in constrictor responses to PAF.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1993
26. INITIAL LOADING THERAPY OF CILOSTAZOL IMPROVED ANTIPLATELET RESPONSIVENESS IN PATIENT WITH PERCUTANEOUS CORONARY INTERVENTION
- Author
-
Moo Hyun Kim, Tae H. Park, Jin Y. Han, Kwang S. Cha, Sun Y. Park, Young D. Kim, Long H. Yu, and Jung Kim
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,medicine.medical_treatment ,Cardiology ,Medicine ,Percutaneous coronary intervention ,In patient ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,Cilostazol ,medicine.drug - Published
- 2010
27. A582 FUNCTIONAL DAMAGE OF THE CORONARY ENDOTHELIUM AFTER A SHORT DURATION OF ISCHEMIA IS REVERSIBLE
- Author
-
J. L. White, Young D. Kim, S. P. Moore, and J. S. Fomsgaard
- Subjects
medicine.medical_specialty ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Endothelium ,business.industry ,Internal medicine ,Ischemia ,medicine ,Coronary endothelium ,Cardiology ,medicine.disease ,business ,Short duration - Published
- 1990
28. Comparison of Thromboxane Synthetase Inhibitor and Methylprednisolone Effects on Protamine Responses in Dogs
- Author
-
T. A. Burke, A V Schaffer, J Peppard, T Viswanathan, F L Douglas, Young D. Kim, J S Fomsgaard, M.R Danchak, and Adam K. Myers
- Subjects
Cardiac output ,medicine.medical_specialty ,Mean arterial pressure ,Protamine sulfate ,Pyridines ,Hemodynamics ,6-Ketoprostaglandin F1 alpha ,Methylprednisolone ,Thromboxane A2 ,chemistry.chemical_compound ,Dogs ,Internal medicine ,medicine.artery ,Animals ,Medicine ,Drug Interactions ,Protamines ,biology ,business.industry ,Imidazoles ,Protamine ,Thromboxane B2 ,Anesthesiology and Pain Medicine ,Endocrinology ,chemistry ,Pulmonary artery ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Thromboxane-A Synthase ,business ,medicine.drug - Abstract
Neutralization of heparin anticoagulation by protamine produces catastrophic hemodynamic reactions in some patients. Using a canine model, we tested effects of thromboxane synthetase inhibition (CGS-13080) and glucocorticoid pretreatment on the cardiorespiratory effects of protamine. In control dogs, protamine decreased mean arterial pressure and cardiac output and increased mean pulmonary artery pressure, systemic and pulmonary vascular resistances (SVR, PVR), and airway pressure. Both CGS-13080 and methylprednisolone ameliorated some effects of protamine. CGS-13080 infusion decreased mean pulmonary artery pressure, SVR, and airway pressure after protamine injection relative to controls. Cardiac output and PVR were unaffected by the drug, whereas the decrease in mean arterial pressure was prolonged. Plasma thromboxane A2 metabolite (TXB2) concentrations were lower and prostacyclin metabolite (6-keto PGF1 alpha) concentrations were higher compared with that of controls. These experiments support a role for TXA2 in the response to protamine. Methylprednisolone pretreatment produced larger cardiac output and lower airway pressure after protamine injection compared with controls. Mean arterial pressure was improved, but not significantly. Mean pulmonary artery pressure, SVR, and PVR were not different from that of controls; TXB2 and 6-keto PGF1 alpha were unaffected. The effects of methylprednisolone appear unrelated to arachidonic acid metabolism, as TXB2 and 6-keto PGF1 alpha levels were unaffected.
- Published
- 1992
29. Effects of hypothermia and hemodilution on oxygen metabolism and hemodynamics in patients recovering from coronary artery bypass operations
- Author
-
Robert B. Wallace, Nevin M. Katz, Lily Ng, Susan W. Ahmed, Young D. Kim, and Ananth Nancherla
- Subjects
Pulmonary and Respiratory Medicine ,medicine.diagnostic_test ,business.industry ,Cardiac index ,Hemodynamics ,Hematocrit ,Hypothermia ,medicine.anatomical_structure ,Anesthesia ,medicine ,Coronary perfusion pressure ,Vascular resistance ,Surgery ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Coronary intensive care ,Oxygen saturation (medicine) - Abstract
The coexistence of hypothermia and hemodilution in patients in the intensive care unit immediately postoperatively after coronary artery bypass graft operations presents concerns regarding the adequacy of hemodynamics and oxygen metabolism. We evaluated the hemodynamic status and oxygen metabolism during the postoperative recovery period in six patients with moderate hemodilution (hematocrit value 34% +/- 3%) and in eight patients with marked hemodilution (hematocrit value 23% +/- 2%). All patients were well sedated and paralyzed with pancuronium bromide during the study period, during which their body temperature was slowly returning toward normal. In both groups, cardiac index at 34 degrees C was about 40% lower than at 37 degrees C. This was associated with 50% higher systemic vascular resistance and 30% lower oxygen availability to tissue. Oxygen consumption, however, was proportionally lower (45%) and coronary perfusion pressure was higher (28%) at 34 degrees C than at 37 degrees C; thus neither mixed venous nor coronary sinus blood oxygen saturation was compromised under hypothermic conditions. Although the trends in hemodynamic changes were similar in both groups, cardiac indices in patients with marked hemodilution were higher than cardiac indices in those with moderate hemodilution at all temperatures. This observation indicates that the hemodilution-induced rise in cardiac index remains intact even under hypothermic conditions. Under the conditions we studied, hypothermia with or without hemodilution had no significant adverse effects on hemodynamics and oxygen metabolisms of the whole body or of the heart.
- Published
- 1989
30. Hemodynamics of protamine administration
- Author
-
Young D. Kim, Nevin M. Katz, Sudha A. Ved, Robert B. Wallace, R. Siegelman, and Susan W. Ahmed
- Subjects
Pulmonary and Respiratory Medicine ,Aorta ,biology ,business.industry ,Hemodynamics ,Heparin ,Protamine ,law.invention ,Catheter ,Route of administration ,medicine.anatomical_structure ,law ,Anesthesia ,medicine.artery ,Cardiopulmonary bypass ,medicine ,biology.protein ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug ,Artery - Abstract
Protamine administration for heparin reversal after cardiopulmonary bypass on occasion is associated with mild to severe hemodynamic deterioration. The route of administration may modify these reactions. A prospective randomized study was done in 68 patients undergoing isolated coronary artery bypass grafting. The route of protamine administration was randomized in a balanced fashion between right atrium, left atrium, and aorta. The preoperative and operative characteristics of the three groups were similar. Hemodynamic measurements were recorded before cannulation, after removal of the venous drainage catheter, and 1 minute, 5 minutes, and 10 minutes after protamine administration. Hypotension occurred in 11 patients with no significant difference among the three groups. The hypotension was immediate in three patients in whom route of administration was the aorta. The overall hemodynamic changes observed for the three treatment groups were not significantly different An analysis for type II error indicated that it was unlikely that an important difference had been missed. We conclude that the route of administration does not affect the hemodynamic changes associated with protamine administration. We did not observe a case of severe hemodynamic deterioration, so that we cannot assess the effect of route of administration on the severity of an anaphylactic reaction.
- Published
- 1987
31. Anesthetic Management of Whole-body Hyperthermia for the Treatment of Cancer
- Author
-
Thomas E. Macnamara, Rosalie Smith, J. M. Bull, Young D. Kim, William Schuette, Jacqueline Whang-Peng, and D. E. Lees
- Subjects
Adult ,Hyperthermia ,Adolescent ,Fever ,MEDLINE ,Pain ,Anesthetic management ,Bioinformatics ,Body Temperature ,Heating ,Text mining ,Neoplasms ,medicine ,Humans ,Neoplasm Metastasis ,Thiopental ,Aged ,Anesthetics ,business.industry ,Cancer ,Neoplasms therapy ,Middle Aged ,medicine.disease ,Fentanyl ,Anesthesiology and Pain Medicine ,Chemical and Drug Induced Liver Injury ,business ,Whole body ,Body Temperature Regulation - Published
- 1980
32. An Unusual Cardiovascular Response to PEEP
- Author
-
Dennis F. Devereux, Young D. Kim, and Thomas E. Macnamara
- Subjects
medicine.medical_specialty ,business.industry ,Pneumonia, Pneumocystis ,Middle Aged ,Hodgkin Disease ,Positive-Pressure Respiration ,Anesthesiology and Pain Medicine ,Text mining ,Tachycardia ,Hypertension ,medicine ,Humans ,Female ,Intensive care medicine ,business - Published
- 1978
33. Effects of halothane on the intramyocardial pressure of the canine left ventricle
- Author
-
Thomas E Macnamara, John C. Rose, Pamela H. Wolf, Young D. Kim, David Nematzadeh, and Peter A. Kot
- Subjects
Male ,medicine.medical_specialty ,Physiology ,Diastole ,Dogs ,Physiology (medical) ,Internal medicine ,medicine ,Pressure ,Animals ,Systole ,Endocardium ,Pressure gradient ,Chemistry ,Heart ,Blood flow ,medicine.anatomical_structure ,Ventricle ,Anesthesia ,cardiovascular system ,Ventricular pressure ,Cardiology ,Female ,Halothane ,Cardiology and Cardiovascular Medicine ,medicine.drug - Abstract
In the intact canine heart a gradient of systolic intramyocardial pressure from a minimum at the epicardial region to a maximum at the endocardial region is well established. No information is, however, available regarding the effects of various anaesthetic agents on this gradient. In the present study the effects of halothane on intramyocardial pressure recorded from subendocardial and subepicardial layers of the canine left ventricular free wall were assessed. Experiments were performed on seven anaesthetised mongrel dogs ventilated with 100% oxygen. Intramyocardial pressure was recorded simultaneously from the inner and outer regions of the myocardium using two Mikro-tip pressure transducers. Halothane concentration in the inspired gas varied from 0% to 2%. In the pentobarbital anaesthetised dog halothane does not significantly change the heart rate. With increasing concentrations of halothane in inspired gas systolic intramyocardial pressure at both endocardium and epicardium decreased significantly from control values. As the halothane concentration increased, the normal differential between systolic left ventricular pressure and endocardial intramyocardial pressure was abolished. The intramyocardial pressure gradient from endocardium to epicardium, however, persisted during systole. During diastole the pressure gradient was reversed, becoming maximum in the epicardial region and minimum in the endocardial region in both control and halothane treated animals. Over the range of 0-2% halothane concentration there was no significant effect on the diastolic intramyocardial pressure gradient. These results suggest that halothane affects the myocardial tissue pressure non-uniformly across the left ventricular free wall and therefore influences the transmural distribution of coronary blood flow. Compared with control animals, halothane treated animals generated an equivalent systolic left ventricular pressure with a lower endocardial intramyocardial pressure, suggesting a beneficial effect on myocardial mechanics during systole.
- Published
- 1986
34. Chemical synthesis of a retroviral nucleic acid binding protein
- Author
-
Stephen Oroszlan, Louis E. Henderson, Terry D. Copeland, Young D. Kim, and Robert J. Gorelick
- Subjects
Biochemistry ,Chemistry ,Nucleic acid ,Nucleic acid methods ,Nucleic acid binding protein ,Chemical synthesis - Published
- 1988
35. Hemodynamic and plasma catecholamine responses to hyperthermic cancer therapy in humans
- Author
-
C. R. Lake, J. M. Bull, D. E. Lees, Young D. Kim, Irwin J. Kopin, W. H. Schuette, and V. Weise
- Subjects
Hyperthermia ,Adult ,Mean arterial pressure ,medicine.medical_specialty ,Central Venous Pressure ,Epinephrine ,Physiology ,Blood Pressure ,Norepinephrine (medication) ,Norepinephrine ,Heart Rate ,Physiology (medical) ,Internal medicine ,Neoplasms ,Heart rate ,medicine ,Humans ,Cardiac Output ,business.industry ,Hemodynamics ,Venous Plasma ,Venous blood ,Hyperthermia, Induced ,Middle Aged ,medicine.disease ,Endocrinology ,Anesthesia ,Catecholamine ,Arterial blood ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Cancer patients, treated with hyperthermia (to 41.5 degrees C) under thiopental and fentanyl anesthesia, had smaller increases in heart rate and cardiac index and lesser decreases in mean arterial pressure than those reported in normal volunteers. At basal body temperature anesthesia did not alter catecholamine levels. Increasing body temperature to 39.5 degrees C and 41.5 degrees C resulted in parallel increases in heart rate and cardiac index that were directly related to the increases in plasma norepinephrine levels. At basal temperature cutaneous venous plasma norepinephrine levels exceeded those of arterial; mixed-venous plasma levels were intermediate. At 39.5 degrees C and 41.5 degrees C there were sequential increases in plasma norepinephrine. The increases in mixed-venous and arterial norepinephrine were significantly greater than in cutaneous venous blood. The differential increases in norepinephrine levels in cutaneous venous, mixed-venous, and arterial blood indicate that during hyperthermia sympathetic nerve activity in skin is decreased while that in other areas is increased, suggesting that alterations in sympathetic activity modulate the hemodynamic changes that attend hyperthermia in man.
- Published
- 1979
36. Postoperative arterial oxygen saturation in the pediatric population during transportation
- Author
-
Young D. Kim, Eva V. Harnik, Bideshwar K. Kataria, Susan Admed, and Rosemary Mitchard
- Subjects
Resuscitation ,Adolescent ,business.industry ,Infant ,Hypoxemia ,Oxygen ,Anesthesiology and Pain Medicine ,Transportation of Patients ,Anesthesia ,Child, Preschool ,medicine ,Humans ,Oximetry ,Postoperative Period ,medicine.symptom ,business ,Anesthesia, Inhalation ,Child ,Pediatric population - Published
- 1988
37. Protamine induced arterial hypoxaemia: the relationship to hypoxic pulmonary vasoconstriction
- Author
-
D. E. Lees, Michael Jones, Richard Michalik, Susan Hanowell, Thomas E. Macnamara, and Young D. Kim
- Subjects
Male ,Pulmonary Circulation ,Protamine sulfate ,Hemodynamics ,Hypoxemia ,Dogs ,Hypoxic pulmonary vasoconstriction ,medicine ,Animals ,Protamines ,Hypoxia ,Lung ,biology ,business.industry ,General Medicine ,respiratory system ,Protamine ,respiratory tract diseases ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Vasoconstriction ,Anesthesia ,Vascular resistance ,biology.protein ,Female ,Vascular Resistance ,medicine.symptom ,business ,medicine.drug - Abstract
Protamine administration may induce arterial hypoxaemia in dogs and humans. However, the responsible mechanism has not been established. Protamine, as it is a pulmonary vasoactive substance, may interfere with normal hypoxic pulmonary vasoconstriction (HPV) and cause arterial hypoxaemia. This possibility was tested in dogs utilizing a one lung hypoxic model. One lung hypoxic ventilation decreased pulmonary blood flow in the hypoxic lung from 1022 +/- 96 ml X min-1 (mean +/- SEM) to 846 +/- 39 ml X min-1 (p less than 0.05) while increasing blood flow from 833 +/- 85 ml X min-1 to 1109 +/- 101 ml X min-1 (p less than 0.05) in the normoxic lung, resulting in 24 per cent effective diversion of blood flow. Protamine infusion, after heparinization, markedly elevated pulmonary vascular resistance in both lungs but preferentially in the normoxic lung (102 +/- 27 per cent increase in normoxic lung, 60 +/- 6.4 per cent increase in hypoxic lung) and significantly reversed the pulmonary blood flow shift induced by one lung hypoxic ventilation (effective diversion of blood flow was reduced to four per cent). Concurrently, arterial PO2 further decreased. Our results demonstrate that protamine interferes with effectiveness of pre-existing HPV and suggest that this mechanism, at least in part, may be responsible for arterial hypoxaemia observed after protamine infusion. The marked generalized pulmonary vasoconstriction with protamine appears to be the direct force that interferes with pre-existing auto-regulatory HPV. In addition to the well known haemodynamic effects of protamine, protamine infusion may also cause arterial hypoxaemia in those patients in whom HPV plays a significant role in maintaining arterial oxygenation.
- Published
- 1985
38. Treatment of non-cardiogenic pulmonary edema following cardiopulmonary bypass with veno-venous extracorporeal membrane oxygenation
- Author
-
Young D. Kim, Neal Fleming, M. A. Pilato, Nevin M. Katz, J. J. O'Connell, R. E. Siegelman, and Mitchell W. Krucoff
- Subjects
Membrane oxygenator ,medicine.medical_treatment ,Pulmonary Edema ,law.invention ,Veins ,Positive-Pressure Respiration ,Extracorporeal Membrane Oxygenation ,law ,Edema ,medicine ,Cardiopulmonary bypass ,Extracorporeal membrane oxygenation ,Humans ,Aged ,Lung ,Cardiopulmonary Bypass ,business.industry ,Respiration, Artificial ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Circulacion extracorporea ,Cardiogenic pulmonary edema ,Anesthesia ,Female ,medicine.symptom ,Complication ,business - Published
- 1988
39. Nonanticoagulant heparin prevents coronary endothelial dysfunction after brief ischemia-reperfusion injury in the dog
- Author
-
Robert L. Hannan, Adam K. Myers, James V. Sitzmann, Yi-Ning Wang, Paul A. Cahill, Young D. Kim, Peter C. Kouretas, and Lam N. To
- Subjects
Male ,medicine.medical_specialty ,Endothelium ,Myocardial Ischemia ,Ischemia ,Myocardial Reperfusion Injury ,Vasodilation ,Nitric Oxide ,Nitric oxide ,chemistry.chemical_compound ,Dogs ,Physiology (medical) ,Internal medicine ,medicine ,Animals ,Endothelial dysfunction ,Blood Coagulation ,Cyclic GMP ,Nitrites ,Nitrates ,Heparin ,business.industry ,Anticoagulants ,medicine.disease ,Coronary Vessels ,medicine.anatomical_structure ,chemistry ,Anesthesia ,Cardiology ,Endothelium, Vascular ,Sodium nitroprusside ,Cardiology and Cardiovascular Medicine ,business ,Reperfusion injury ,medicine.drug - Abstract
Background —Coronary endothelial dysfunction after brief ischemia-reperfusion (IR) remains a clinical problem. We investigated the role of heparin and N -acetylheparin, a nonanticoagulant heparin derivative, in modulating coronary endothelial function after IR injury, with an emphasis on defining the role of the nitric oxide (NO)–cGMP pathway in the heparin-mediated effect. Methods and Results —Male mongrel dogs were surgically instrumented, and the effects of both bovine heparin and N -acetylheparin on coronary endothelial vasomotor function, expressed as percent change from baseline flow after acetylcholine challenge, were studied after 15 minutes of regional ischemia of the left anterior descending artery (LAD) followed by 120 minutes of reperfusion. In dogs treated with placebo (saline), coronary vasomotor function was significantly ( P ≤0.03) decreased after 15 and 30 minutes of reperfusion (65±12% and 73±12%) compared with preischemia (103±6%). In contrast, the vasodilatory response to the endothelium-independent vasodilator sodium nitroprusside was maintained during reperfusion. Preischemic administration of both bovine heparin and N -acetylheparin (6.0 mg/kg IV) preserved coronary endothelial function throughout reperfusion. In a parallel group of dogs, nitrate/nitrite (NOx) and cGMP levels in the LAD were measured after treatment and during 15-minute reperfusion. Preischemic administration of N -acetylheparin caused a significant increase in basal NOx and cGMP levels compared with saline controls. Pretreatment with N -acetylheparin also caused a significant increase in NOx and cGMP levels in the LAD after 15 minutes of reperfusion compared with IR alone. Conclusions —These results suggest that heparin preserves coronary endothelial function after brief IR injury by a mechanism independent of its anticoagulant activity and that the effect of heparin may be mediated in part by activation of the NO-cGMP pathway.
40. Unusual Cause of Weakness of the Lower Extremity Following Vaginal Delivery under Epidural Analgesia
- Author
-
Victor C. Lee, Young D. Kim, and Young K. Shin
- Subjects
Weakness ,business.industry ,Vaginal delivery ,Iliopsoas Muscle ,Strain (injury) ,Anatomy ,Thigh ,medicine.disease ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Anesthesia ,Sprains and strains ,medicine ,medicine.symptom ,business ,Anesthesia epidural - Published
- 1985
41. PULMONARY SHUNTING WITH HYPERTHERMIA UNDER ANESTHESIA
- Author
-
Young D. Kim, T. E. Macnamara, and D. E. Lees
- Subjects
Hyperthermia ,Shunting ,Anesthesiology and Pain Medicine ,business.industry ,Anesthesia ,medicine ,medicine.disease ,business - Published
- 1979
42. COMPUTERIZED DETERMINATION OF OXYGEN DISSOCIATION CURVE
- Author
-
H. Tipton, William H. Schuette, Thomas E. Macnamara, L. E. Thibault, D. E. Lees, and Young D. Kim
- Subjects
Anesthesiology and Pain Medicine ,business.industry ,Analytical chemistry ,Medicine ,Oxygen–haemoglobin dissociation curve ,business - Published
- 1980
43. Unusual Cause of Weakness of the Lower Extremity Following Vaginal Delivery Under Epidural Analgesia
- Author
-
Young D. Kim, Victor C. Lee, and Young K. Shin
- Subjects
Weakness ,Iliopsoas Muscle ,business.industry ,Vaginal delivery ,Anesthesia ,medicine ,Strain (injury) ,Anatomy ,medicine.symptom ,medicine.disease ,business - Published
- 1986
44. HYPERTHERMIC ALTERATION OF SYMPATHETIC ACTIVITY
- Author
-
Young D. Kim, C. R. Lake, J. M. Bull, D. E. Lees, Thomas E. Macnamara, V. Weise, and Irwin J. Kopin
- Subjects
medicine.medical_specialty ,Anesthesiology and Pain Medicine ,Endocrinology ,business.industry ,Internal medicine ,Medicine ,Sympathetic activity ,business - Published
- 1979
45. N2O ADDITION TO HALOTHANE AND ENFLURANE
- Author
-
Young D. Kim, M. Jones, E. Pierce, Susan T. Hanowell, and Thomas E. Macnamara
- Subjects
Coronary artery disease ,Stimulant ,medicine.medical_specialty ,Anesthesiology and Pain Medicine ,business.industry ,Internal medicine ,medicine.medical_treatment ,medicine ,Cardiology ,Halothane ,medicine.disease ,business ,medicine.drug - Published
- 1982
46. Prolonged Induction with Exaggerated Chamber Enlargement in Ebstein??s Anomaly
- Author
-
Young D. Kim, Jane L. Elsten, Thomas E. Macnamara, and Susan T. Hanowell
- Subjects
medicine.medical_specialty ,Anesthesiology and Pain Medicine ,business.industry ,Ebstein's anomaly ,Internal medicine ,Cardiology ,Medicine ,business ,medicine.disease - Published
- 1981
47. Noninvasive Determination of Core Temperature During Anesthesia
- Author
-
Young D. Kim, Lees De, and Macnamara Te
- Subjects
Hyperthermia ,Blood temperature ,Thermometers ,Anesthesia, General ,Pulmonary Artery ,Core temperature ,Intracardiac injection ,Body Temperature ,Neoplasms ,medicine.artery ,Humans ,Medicine ,Monitoring, Physiologic ,Vasomotor ,business.industry ,Thermistor ,Heart ,Hyperthermia, Induced ,General Medicine ,medicine.disease ,Blood ,Anesthesia ,Pulmonary artery ,cardiovascular system ,business ,Whole body - Abstract
A noninvasive, zero heat flux method of determining core (intracardiac blood) temperature was studied in ten anesthetized patients having whole body hyperthermia for the treatment of cancer. True intracardiac blood temperature was determined by a calibrated pulmonary artery thermistor. Accuracy, precision, and responsivity for the noninvasive system were comparable to conventional esophageal thermometry in reflecting intracardiac blood temperatures. This method of contact thermometry is convenient and independent of environmental influence, and it rapidly reflects the small changes in arterial blood temperature which evoke vasomotor responses.
- Published
- 1980
48. DISCREPANT EFFECTS OF CHEMOTHERAPY ON RADIOGALLIUM AND RADIOCOLLOID SCANS IN NULL CELL LEUKEMIA/LYMPHOMA
- Author
-
Mozafar K. Karimeddini, Daniel M. Roswig, Young D. Kim, Elcon D. Levinson, Richard P. Spencer, Pachagirl Suresh, Bijay Mukherji, and Nicholas J. Robert
- Subjects
Chemotherapy ,Leukemia lymphoma ,business.industry ,medicine.medical_treatment ,medicine ,Cancer research ,Null cell ,Radiology, Nuclear Medicine and imaging ,General Medicine ,business - Published
- 1983
49. PRIMARY ALDOSTERONISM
- Author
-
S. T. Hanowell, T. E. Macnamara, Young D. Kim, and K. C. Hittner
- Subjects
03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,Anesthesiology and Pain Medicine ,Primary (chemistry) ,030202 anesthesiology ,business.industry ,Family medicine ,medicine ,business ,030217 neurology & neurosurgery - Published
- 1980
50. THE EFFECT OF INTRA-OPERATIVE FACTORS ON EARLY EXTUBATION FOLLOWING MITRAL VALVE REPLACEMENT
- Author
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R. B. Wallace, C. Kim, T. E. Macnamara, Young D. Kim, R. K.P. Kareti, P. Belchere, and E. Pierce
- Subjects
medicine.medical_specialty ,Anesthesiology and Pain Medicine ,Intra operative ,business.industry ,medicine.medical_treatment ,Mitral valve replacement ,medicine ,business ,Surgery - Published
- 1984
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