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12 results on '"Young, Patric"'

1. Drug‐Eluting Shear‐Thinning Hydrogel for the Delivery of Chemo‐ and Immunotherapeutic Agents for the Treatment of Hepatocellular Carcinoma

Author

Falcone, Natashya, primary, Ermis, Menekse, additional, Gangrade, Ankit, additional, Choroomi, Auveen, additional, Young, Patric, additional, Mathes, Tess G., additional, Monirizad, Mahsa, additional, Zehtabi, Fatemeh, additional, Mecwan, Marvin, additional, Rodriguez, Marco, additional, Zhu, Yangzhi, additional, Byun, Youngjoo, additional, Khademhosseini, Ali, additional, de Barros, Natan Roberto, additional, and Kim, Han‐Jun, additional

Published
2023
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2. Gelatin methacryloyl and Laponite bioink for 3D bioprinted organotypic tumor modeling

Author

de Barros, Natan Roberto, primary, Gomez, Alejandro, additional, Ermis, Menekse, additional, Falcone, Natashya, additional, Haghniaz, Reihaneh, additional, Young, Patric, additional, Gao, Yaqi, additional, Aquino, Albert-Fred, additional, Li, Siyuan, additional, Niu, Siyi, additional, Chen, RunRun, additional, Huang, Shuyi, additional, Zhu, Yangzhi, additional, Eliahoo, Payam, additional, Sun, Arthur, additional, Khorsandi, Danial, additional, Kim, Jinjoo, additional, Kelber, Jonathan, additional, Khademhosseini, Ali, additional, Kim, Han-Jun, additional, and Li, Bingbing, additional

Published
2023
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3. Drug‐Eluting Shear‐Thinning Hydrogel for the Delivery of Chemo‐ and Immunotherapeutic Agents for the Treatment of Hepatocellular Carcinoma.

Author

Falcone, Natashya, Ermis, Menekse, Gangrade, Ankit, Choroomi, Auveen, Young, Patric, Mathes, Tess G., Monirizad, Mahsa, Zehtabi, Fatemeh, Mecwan, Marvin, Rodriguez, Marco, Zhu, Yangzhi, Byun, Youngjoo, Khademhosseini, Ali, de Barros, Natan Roberto, and Kim, Han‐Jun

Subjects
HEPATOCELLULAR carcinoma, IMMUNE checkpoint inhibitors, CHEMOEMBOLIZATION, LIVER cancer, CANCER treatment, POLYMERSOMES
Abstract

Hepatocellular carcinoma (HCC) is a malignant and deadly form of liver cancer with limited treatment options. Transcatheter arterial chemoembolization, a procedure that delivers embolic and chemotherapeutic agents through blood vessels, is a promising cancer treatment strategy. However, it still faces limitations, such as inefficient agent delivery and the inability to address tumor‐induced immunosuppression. Here, a drug‐eluting shear‐thinning hydrogel (DESTH) loaded with chemotherapeutic and immunotherapeutic agents in nanocomposite hydrogels composed of gelatin and nanoclays is presented as a therapeutic strategy for a catheter‐based endovascular anticancer approach. DESTH is manually deliverable using a conventional needle and catheter. In addition, drug release studies show a sustained and pH‐dependent co‐delivery of the chemotherapy doxorubicin (acidic pH) and the immune‐checkpoint inhibitor aPD‐1 (neutral pH). In a mouse liver tumor model, the DESTH‐based chemo/immunotherapy combination has the highest survival rate and smallest residual tumor size. Finally, immunofluorescence analysis confirms that DESTH application enhances cell death and increases intratumoral infiltration of cytotoxic T‐cells. In conclusion, the results show that DESTH, which enables efficient ischemic tumor cell death and effective co‐delivery of chemo‐ and immunotherapeutic agents, may have the potential to be an effective therapeutic modality in the treatment of HCC. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Author

Zhu, Yangzhi, Li, Shaopei, Li, Jinghang, Falcone, Natashya, Cui, Qingyu, Shah, Shilp, Hartel, Martin C., Yu, Ning, Young, Patric, de Barros, Natan Roberto, Wu, Zhuohong, Haghniaz, Reihaneh, Ermis, Menekse, Wang, Canran, Kang, Heemin, Lee, Junmin, Karamikamkar, Solmaz, Ahadian, Samad, Jucaud, Vadim, Dokmeci, Mehmet R., Kim, Han-Jun, Khademhosseini, Ali, Zhu, Yangzhi, Li, Shaopei, Li, Jinghang, Falcone, Natashya, Cui, Qingyu, Shah, Shilp, Hartel, Martin C., Yu, Ning, Young, Patric, de Barros, Natan Roberto, Wu, Zhuohong, Haghniaz, Reihaneh, Ermis, Menekse, Wang, Canran, Kang, Heemin, Lee, Junmin, Karamikamkar, Solmaz, Ahadian, Samad, Jucaud, Vadim, Dokmeci, Mehmet R., Kim, Han-Jun, and Khademhosseini, Ali

Abstract

The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of non-invasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, we discussed the current status and potential of SCL development through a comprehensive review from fabrication to applications to commercialization. First, we discuss the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications. Then, we review the latest advances in diagnostic and therapeutic SCLs for clinical translation. Later, we summarize the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices. We also provide an outlook, future opportunities, and challenges for developing next-generation SCL devices. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.

Published
2022

5. Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Author

Zhu, Yangzhi, primary, Li, Shaopei, additional, Li, Jinghang, additional, Falcone, Natashya, additional, Cui, Qingyu, additional, Shah, Shilp, additional, Hartel, Martin C., additional, Yu, Ning, additional, Young, Patric, additional, de Barros, Natan Roberto, additional, Wu, Zhuohong, additional, Haghniaz, Reihaneh, additional, Ermis, Menekse, additional, Wang, Canran, additional, Kang, Heemin, additional, Lee, Junmin, additional, Karamikamkar, Solmaz, additional, Ahadian, Samad, additional, Jucaud, Vadim, additional, Dokmeci, Mehmet R., additional, Kim, Han‐Jun, additional, and Khademhosseini, Ali, additional

Published
2022
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6. pH-Responsive doxorubicin delivery using shear-thinning biomaterials for localized melanoma treatment

Author

Lee, Junmin, primary, Wang, Yonggang, additional, Xue, Chengbin, additional, Chen, Yi, additional, Qu, Moyuan, additional, Thakor, Jai, additional, Zhou, Xingwu, additional, Barros, Natan Roberto, additional, Falcone, Natashya, additional, Young, Patric, additional, van den Dolder, Floor W., additional, Lee, KangJu, additional, Zhu, Yangzhi, additional, Cho, Hyun-Jong, additional, Sun, Wujin, additional, Zhao, Bo, additional, Ahadian, Samad, additional, Jucaud, Vadim, additional, Dokmeci, Mehmet R., additional, Khademhosseini, Ali, additional, and Kim, Han-Jun, additional

Published
2022
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7. Recent developments in mussel-inspired materials for biomedical applications

Author

Barros, Natan Roberto, primary, Chen, Yi, additional, Hosseini, Vahid, additional, Wang, Weiyue, additional, Nasiri, Rohollah, additional, Mahmoodi, Mahboobeh, additional, Yalcintas, Ezgi Pinar, additional, Haghniaz, Reihaneh, additional, Mecwan, Marvin Magan, additional, Karamikamkar, Solmaz, additional, Dai, Wei, additional, Sarabi, Shima A., additional, Falcone, Natashya, additional, Young, Patric, additional, Zhu, Yangzhi, additional, Sun, Wujin, additional, Zhang, Shiming, additional, Lee, Junmin, additional, Lee, Kangju, additional, Ahadian, Samad, additional, Dokmeci, Mehmet Remzi, additional, Khademhosseini, Ali, additional, and Kim, Han-Jun, additional

Published
2021
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