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3. Incidence of Type 2 Diabetes in Children With Nonalcoholic Fatty Liver Disease

Author

Newton, Kimberly P, Wilson, Laura A, Crimmins, Nancy A, Fishbein, Mark H, Molleston, Jean P, Xanthakos, Stavra A, Behling, Cynthia, Schwimmer, Jeffrey B, Network, Nonalcoholic Steatohepatitis Clinical Research, Garner, Donna, Hertel, Paula, Lawson, Alicia, Pham, Yen, Triggs, Nicole, Bramlage, Kristin, Carr, April, McNeill, Meghan, Mouzaki, Marialena, Xanthakos, Stavra, Alazraki, Adina, Cleeton, Rebecca, Cordero, Maria, Karpen, Saul, Vos, Miriam, Carr, Laura, Cummings, Oscar W, Harlow, Kathryn, Klipsch, Ann, Morlan, Wendy, Ragozzino, Emily, Sawyers, Cindy, Anthony, Angela, Cattoor, Theresa, Freebersyser, Janet, Jain, Ajay K, Torretta, Susan, Durelle, Janis, Goyal, Nidhi P, Ugalde-Nicalo, Patricia, Wang, Andrew, Blondet, Niviann, Cooper, Kara, Otto, Randolph, Yeh, Matthew, Young, Melissa, Kleiner, David E, Doo, Edward C, Hall, Sherry, Hoofnagle, Jay H, Sherker, Averell H, Torrance, Rebecca, Robuck, Patricia R, Adamo, Peggy, Belt, Patricia, Clark, Jeanne M, Meinert, Jill, Miriel, Laura, Shade, Carrie, Sharkey, Emily P, Smith, Jacqueline, Smith, Michael, Sternberg, Alice, Tonascia, ScM James, Van Natta, Mark L, Wagoner, Annette, Woreta, Tinsay, Yates, Katherine P, Dodge, John, Donithan, Michele, and Isaacson, Milana

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Prevention, Digestive Diseases, Nutrition, Clinical Research, Chronic Liver Disease and Cirrhosis, Hepatitis, Diabetes, Liver Disease, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Male, Humans, Female, Child, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Type 2, Incidence, Liver, Risk Factors, Obesity, Gender, Hispanic, Steatohepatitis, Nonalcoholic Steatohepatitis Clinical Research Network, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsType 2 diabetes (T2D) is a growing problem in children. Children with NAFLD are at potentially high risk for developing T2D; however, the incidence of T2D in this population is unknown. This study aimed to determine the incidence of T2D in children with NAFLD and identify associated risk factors.MethodsChildren with NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network were followed longitudinally. Incidence of T2D was determined by using clinical history and fasting laboratory values. Cumulative incidence curves were developed for time to T2D. A Cox regression multivariable model was constructed using best subsets Akaike's Information Criteria selection.ResultsThis study included 892 children with NAFLD and with a mean age of 12.8 years (2.7) followed for 3.8 years (2.3) with a total 3234 person-years at risk. The incidence rate of T2D was 3000 new cases per 100,000 person-years at risk. At baseline, 63 children had T2D, and during follow-up, an additional 97 children developed incident T2D, resulting in a period prevalence of 16.8%. Incident T2D was significantly higher in females versus males (hazard ratio [HR], 1.8 [1.0-2.8]), associated with BMI z-score (HR, 1.8 [1.0-3.0]), and more severe liver histology including steatosis grade (HR, 1.3 [1.0-1.7]), and fibrosis stage (HR, 1.3 [1.0-1.5]).ConclusionsChildren with NAFLD are at high risk for existing and incident T2D. In addition to known risk factors for T2D (female and BMI z-score), severity of liver histology at the time of NAFLD diagnosis was independently associated with T2D development. Targeted strategies to prevent T2D in children with NAFLD are needed.

Published
2023

4. Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease

Author

Leung, Daniel H, Devaraj, Sridevi, Goodrich, Nathan P, Chen, Xinpu, Rajapakshe, Deepthi, Ye, Wen, Andreev, Victor, Minard, Charles G, Guffey, Danielle, Molleston, Jean P, Bass, Lee M, Karpen, Saul J, Kamath, Binita M, Wang, Kasper S, Sundaram, Shikha S, Rosenthal, Philip, McKiernan, Patrick, Loomes, Kathleen M, Jensen, M Kyle, Horslen, Simon P, Bezerra, Jorge A, Magee, John C, Merion, Robert M, Sokol, Ronald J, Shneider, Benjamin L, Network, The Childhood Liver Disease Research, Alonso, Estella, Bass, Lee, Kelly, Susan, Riordan, Mary, Melin‐Aldana, Hector, Bezerra, Jorge, Bove, Kevin, Heubi, James, Miethke, Alexander, Tiao, Greg, Denlinger, Julie, Chapman, Erin, Sokol, Ronald, Feldman, Amy, Mack, Cara, Narkewicz, Michael, Suchy, Frederick, Van Hove, Johan, Garcia, Benigno, Kauma, Mikaela, Kocher, Kendra, Steinbeiss, Matthew, Lovell, Mark, Piccoli, David, Rand, Elizabeth, Russo, Pierre, Spinner, Nancy, Erlichman, Jessi, Stalford, Samantha, Pakstis, Dina, King, Sakya, Squires, Robert, Sindhi, Rakesh, Venkat, Veena, Bukauskas, Kathy, Haberstroh, Lori, Squires, James, Bull, Laura, Curry, Joanna, Langlois, Camille, Kim, Grace, Teckman, Jeffery, Kociela, Vikki, Nagy, Rosemary, Patel, Shraddha, Cerkoski, Jacqueline, Bozic, Molly, Subbarao, Girish, Klipsch, Ann, Sawyers, Cindy, Cummings, Oscar, Murray, Karen, Hsu, Evelyn, Cooper, Kara, Young, Melissa, Finn, Laura, Ng, Vicky, Quammie, Claudia, Putra, Juan, Sharma, Deepika, Parmar, Aishwarya, Guthery, Stephen, Jensen, Kyle, Rutherford, Ann, Lowichik, Amy, Book, Linda, and Meyers, Rebecka

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Chronic Liver Disease and Cirrhosis, Rare Diseases, Pediatric, Liver Disease, Digestive Diseases, Oral and gastrointestinal, Humans, Child, Liver, Matrix Metalloproteinase 7, Endoglin, Interleukin-8, Cholestasis, Liver Cirrhosis, Liver Diseases, Biomarkers, Alagille Syndrome, Elasticity Imaging Techniques, Childhood Liver Disease Research Network, Medical Biochemistry and Metabolomics, Immunology, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background and aimsDetailed investigation of the biological pathways leading to hepatic fibrosis and identification of liver fibrosis biomarkers may facilitate early interventions for pediatric cholestasis.Approach and resultsA targeted enzyme-linked immunosorbent assay-based panel of nine biomarkers (lysyl oxidase, tissue inhibitor matrix metalloproteinase (MMP) 1, connective tissue growth factor [CTGF], IL-8, endoglin, periostin, Mac-2-binding protein, MMP-3, and MMP-7) was examined in children with biliary atresia (BA; n = 187), alpha-1 antitrypsin deficiency (A1AT; n = 78), and Alagille syndrome (ALGS; n = 65) and correlated with liver stiffness (LSM) and biochemical measures of liver disease. Median age and LSM were 9 years and 9.5 kPa. After adjusting for covariates, there were positive correlations among LSM and endoglin ( p = 0.04) and IL-8 ( p

Published
2023

6. Maternal low and high hemoglobin concentrations and associations with adverse maternal and infant health outcomes: an updated global systematic review and meta-analysis

Author

Young, Melissa F, Oaks, Brietta M, Rogers, Hannah Paige, Tandon, Sonia, Martorell, Reynaldo, Dewey, Kathryn G, and Wendt, Amanda S

Subjects
Biomedical and Clinical Sciences, Midwifery, Public Health, Health Sciences, Reproductive Medicine, Perinatal Period - Conditions Originating in Perinatal Period, Infant Mortality, Pediatric, Hematology, Preterm, Low Birth Weight and Health of the Newborn, Reproductive health and childbirth, Good Health and Well Being, Pregnancy, Female, Child, Infant, Newborn, Humans, Pregnancy Outcome, Stillbirth, Premature Birth, Anemia, Iron-Deficiency, Pre-Eclampsia, Infant Health, Anemia, Hemoglobins, Hemoglobin, anemia, Review, Birth outcomes, Nursing, Paediatrics and Reproductive Medicine, Public Health and Health Services, Obstetrics & Reproductive Medicine, Reproductive medicine
Abstract

BackgroundGrowing evidence suggests low and high maternal hemoglobin (Hb) concentrations may have adverse consequences for maternal and child health. There remain questions on specific Hb thresholds to define anemia and high Hb as well as how cutoffs may vary by anemia etiology and timing of assessment.MethodsWe conducted an updated systematic review (using PubMed and Cochrane Review) on low (

Published
2023

7. The Relationship Between Ferritin and BMI is Mediated by Inflammation Among Women in Higher-Income Countries, But Not in Most Lower-Income Countries Nor Among Young Children: A Multi-Country Analysis

Author

Davis, Jennie N, Williams, Anne, Arnold, Charles D, Rohner, Fabian, Wirth, James P, Addo, Yaw, Flores-Ayala, Rafael C, Oaks, Brietta M, Young, Melissa F, Suchdev, Parminder S, and Engle-Stone, Reina

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Clinical Research, Prevention, Nutrition, Good Health and Well Being, ferritin, inflammation, acute phase proteins, iron status, assessment, biomarker, overweight, obesity, Animal production, Food sciences, Nutrition and dietetics
Abstract

BackgroundIn the presence of inflammation, the serum or plasma ferritin concentration ("ferritin" hereafter) transiently increases, confounding its interpretation as an iron status marker. The extent to which adiposity-related inflammation may influence ferritin interpretation is uncertain.ObjectivesWe describe relationships between weight status, inflammation, and ferritin among nonpregnant women of reproductive age (WRA; 15-49 years) and preschool-age children (PSC; 6-59 months) with normal weight to overweight or obesity (OWOB) in differing geographic settings.MethodsCross-sectional data were separately analyzed from 18 surveys (WRA) and 25 surveys (PSC) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project, excluding observations with underweight, wasting, pregnancy, or malaria. Relationships were assessed between BMI (in WRA) or BMI-for-age z-score (BAZ; in PSC), inflammatory biomarkers of C-reactive protein (CRP) and/or α-1-acid glycoprotein (AGP), ferritin by linear regression, and potential mediation by CRP and/or AGP in relationships between BMI or BAZ and ferritin with structural equation modeling. Regression and mediation models accounted for complex survey designs. Results were grouped by World Bank income classifications.ResultsIn 5 of 6 surveys among WRA from upper-middle and high-income countries, ferritin was significantly positively associated with BMI, and this relationship was partially (or fully, in the United States) mediated by CRP and/or AGP. Mediation was present in 4 of 12 surveys for WRA in low- and lower-middle income countries. Among PSC, ferritin was positively associated with CRP and/or AGP in all surveys, but there were no significant CRP- or AGP-mediated relationships between ferritin and BAZ, except a negative relationship in the Philippines.ConclusionsWhere having OWOB is common among WRA, measurements of inflammatory biomarkers and their uses in interpreting ferritin may improve iron status assessments. While these relationships were inconsistent among PSC, inflammation was common and should be measured to interpret iron status. Included Kenyan trial data are registered at clinicaltrials.gov as NCT01088958.

Published
2022

11. The Association Between Breastfeeding and Growth Among Infants with Moderately Low Birth Weight: A Prospective Cohort Study

Author

North, Krysten, Semrau, Katherine E.A., Bellad, Roopa M., Dhaded, Sangappa M., Das, Leena, Behera, Jnanindranath N., Hoffman, Irving, Mvalo, Tisungane, Kisenge, Rodrick, Sudfeld, Christopher R., Somji, Sarah, Mokhtar, Rana R., Vesel, Linda, Goudar, Shivaprasad, Vernekar, Sunil S., Siddhartha, E.S., Singh, Bipsa, Koujalagi, M.B., Panda, Sanghamitra, Kafansiyanji, Eddah, Nyirenda, Naomie, Phiri, Melda, Saidi, Friday, Masoud, Nahya S., Moshiro, Robert, Tuller, Danielle E., Israel-Ballard, Kiersten, Duggan, Christopher P., Lee, Anne C.C., Mansen, Kimberly L., Young, Melissa F., and Manji, Karim

Published
2024
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13. Facilitators, barriers, and key influencers of breastfeeding among low birthweight infants: a qualitative study in India, Malawi, and Tanzania

Author

Vesel, Linda, Benotti, Emily, Somji, Sarah, Bellad, Roopa M, Charantimath, Umesh, Dhaded, Sangappa M, Goudar, Shivaprasad S, Karadiguddi, Chandrashekhar, Mungarwadi, Geetanjali, Vernekar, Sunil S, Kisenge, Rodrick, Manji, Karim, Salim, Nahya, Samma, Abraham, Sudfeld, Christopher R, Hoffman, Irving F, Mvalo, Tisungane, Phiri, Melda, Saidi, Friday, Tseka, Jennifer, Tsidya, Mercy, Caruso, Bethany A, Duggan, Christopher P, Israel-Ballard, Kiersten, Lee, Anne CC, Mansen, Kimberly L, Martin, Stephanie L, North, Krysten, Young, Melissa F, Fishman, Eliza, Fleming, Katelyn, Semrau, Katherine EA, Spigel, Lauren, Tuller, Danielle E, and Henrich, Natalie

Published
2023
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17. Approaches to quantify the contribution of multiple anemia risk factors in children and women from cross-sectional national surveys.

Author

Ko, Yi-An, Williams, Anne, Peerson, Janet, Luo, Hanqi, Flores-Ayala, Rafael, Wirth, James, Engle-Stone, Reina, Young, Melissa, and Suchdev, Parminder

Abstract

BACKGROUND: Attributable fractions (AF) of anemia are often used to understand the multifactorial etiologies of anemia, despite challenges interpreting them in cross-sectional studies. We aimed to compare different statistical approaches for estimating AF for anemia due to inflammation, malaria, and micronutrient deficiencies including iron, vitamin A, vitamin B12, and folate. METHODS: AF were calculated using nationally representative survey data among preschool children (10 countries, total N = 7,973) and nonpregnant women of reproductive age (11 countries, total N = 15,141) from the Biomarkers Reflecting Inflammation and Nutrition Determinants of Anemia (BRINDA) project. We used the following strategies to calculate AF: 1) Levins formula with prevalence ratio (PR) in place of relative risk (RR), 2) Levins formula with odds ratio (OR) in place of RR, and 3) average (sequential) AF considering all possible removal sequences of risk factors. PR was obtained by 1) modified Poisson regression with robust variance estimation, 2) Kleinman-Nortons approach, and 3) estimation from OR using Zhang-Yus approach. Survey weighted country-specific analysis was performed with and without adjustment for age, sex, socioeconomic status, and other risk factors. RESULTS: About 20-70% of children and 20-50% of women suffered from anemia, depending on the survey. Using OR yielded the highest and potentially biased AF, in some cases double those using PR. Adjusted AF using different PR estimations (Poisson regression, Kleinman-Norton, Zhang-Yu) were nearly identical. Average AF estimates were similar to those using Levins formula with PR. Estimated anemia AF for children and women were 2-36% and 3-46% for iron deficiency,

Published
2022

18. Insights into the Mechanism of Methanol Steam Reforming Tandem Reaction over CeO2 Supported Single-Site Catalysts

Author

Chen, Luning, Qi, Zhiyuan, Peng, Xinxing, Chen, Jeng-Lung, Pao, Chih-Wen, Zhang, Xibo, Dun, Chaochao, Young, Melissa, Prendergast, David, Urban, Jeffrey J, Guo, Jinghua, Somorjai, Gabor A, and Su, Ji

Subjects
Chemical Sciences, Physical Chemistry, Affordable and Clean Energy, General Chemistry, Chemical sciences, Engineering
Abstract

We demonstrated how the special synergy between a noble metal single site and neighboring oxygen vacancies provides an "ensemble reaction pool" for high hydrogen generation efficiency and carbon dioxide (CO2) selectivity of a tandem reaction: methanol steam reforming. Specifically, the hydrogen generation rate over single site Ru1/CeO2 catalyst is up to 9360 mol H2 per mol Ru per hour (579 mLH2 gRu-1 s-1) with 99.5% CO2 selectivity. Reaction mechanism study showed that the integration of metal single site and O vacancies facilitated the tandem reaction, which consisted of methanol dehydrogenation, water dissociation, and the subsequent water gas shift (WGS) reaction. In addition, the strength of CO adsorption and the reaction activation energy difference between methanol dehydrogenation and WGS reaction play an important role in determining the activity and CO2 selectivity. Our study paves the way for the further rational design of single site catalysts at the atomic scale. Furthermore, the development of such highly efficient and selective hydrogen evolution systems promises to deliver highly desirable economic and ecological benefits.

Published
2021

22. Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990–2021: findings from the Global Burden of Disease Study 2021

Author

Gardner, William M, Razo, Christian, McHugh, Theresa A, Hagins, Hailey, Vilchis-Tella, Victor M, Hennessy, Conor, Taylor, Heather Jean, Perumal, Nandita, Fuller, Kia, Cercy, Kelly M, Zoeckler, Leo Zucker, Chen, Catherine S, Lim, Stephen S, Aali, Amirali, Abate, Kalkidan Hassen, Abd-Elsalam, Sherief, Abdurehman, Ame Mehadi, Abebe, Getachew, Abidi, Hassan, Aboagye, Richard Gyan, Abolhassani, Hassan, Aboye, Girma Beressa Aboye, Abtew, Yonas Derso, Accrombessi, Manfred Mario Kokou, Adane, Denberu Eshetie Adane, Adane, Tigist Demssew, Addo, Isaac Yeboah, Adesina, Miracle Ayomikun, Adeyinka, Daniel Adedayo, Adnani, Qorinah Estiningtyas Sakilah, Afzal, Muhammad Sohail, Afzal, Saira, Agustina, Rina, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Sajjad, Ahmadi, Sepideh, Ahmed, Ayman, Ahmed Rashid, Tarik, Aiman, Wajeeha, Ajami, Marjan, Akbarialiabad, Hossein, Alahdab, Fares, Al-Aly, Ziyad, Alam, Nazmul, Alemayehu, Astawus, Alhassan, Robert Kaba, Ali, Muhammad Ashar, Almustanyir, Sami, Al-Raddadi, Rajaa M, Al-Rifai, Rami H, Altirkawi, Khalid A, Alvand, Saba, Alvis-Guzman, Nelson, Amer, Yasser Sami Abdel Dayem, Ameyaw, Edward Kwabena, Amu, Hubert, Anagaw, Tadele Fentabil, Ancuceanu, Robert, Anoushirvani, Ali Arash, Antwi, Maxwell Hubert, Anvari, Davood, Arabloo, Jalal, Aravkin, Aleksandr Y, Ariffin, Hany, Aripov, Timur, Arja, Asrat, Arndt, Michael Benjamin, Arulappan, Judie, Aruleba, Raphael Taiwo, Ashraf, Tahira, Asresie, Melash Belachew, Athari, Seyyed Shamsadin, Atlaw, Daniel, Aujayeb, Avinash, Awoke, Andargie Abate, Awoke, Mamaru Ayenew, Azadnajafabad, Sina, Azangou-Khyavy, Mohammadreza, B, Darshan B, Badawi, Alaa, Badiye, Ashish D, Baghcheghi, Nayereh, Bagheri, Nasser, Bagherieh, Sara, Baig, Atif Amin, Banach, Maciej, Banik, Palash Chandra, Bantie, Abere Tilahun, Barr, Ronald D, Barrow, Amadou, Bashiri, Azadeh, Basu, Saurav, Batiha, Abdul-Monim Mohammad, Begum, Tahmina, Belete, Melaku Ashagrie, Belo, Luis, Bensenor, Isabela M, Berhie, Alemshet Yirga, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhat, Ajay Nagesh, Bhutta, Zulfiqar A, Bikbov, Boris, Billah, Sk Masum, Birara, Setognal, Bishai, Jessica Devin, Bitaraf, Saeid, Boloor, Archith, Botelho, João Silva Botelho, Burkart, Katrin, Calina, Daniela, Cembranel, Francieli, Chakraborty, Promit Ananyo, Chanie, Gashaw Sisay, Chattu, Vijay Kumar, Chien, Ju-Huei, Chukwu, Isaac Sunday, Chung, Eunice, Criqui, Michael H, Cruz-Martins, Natália, Dadras, Omid, Dagnew, Gizachew Worku, Dai, Xiaochen, Danawi, Hadi A, Dandona, Lalit, Dandona, Rakhi, Darwesh, Aso Mohammad, Das, Jai K, Das, Saswati, De la Cruz-Góngora, Vanessa, Demisse, Fitsum Wolde, Demissie, Solomon, Demsie, Desalegn Getnet, Desai, Hardik Dineshbhai, Desalegn, Markos Desalegn, Dessalegn, Fikadu Nugusu, Dessie, Gashaw, Dharmaratne, Samath Dhamminda, Dhimal, Meghnath, Dhingra, Sameer, Diaz, Daniel, Didehdar, Mojtaba, Dirac, M Ashworth, Diress, Mengistie, Doaei, Saeid, Dodangeh, Milad, Doku, Paul Narh, Dongarwar, Deepa, Dora, Bezabih Terefe, Dsouza, Haneil Larson, Edinur, Hisham Atan, Ekholuenetale, Michael, Elagali, Ahmed Elabbas Mustafa, Elbahnasawy, Mostafa Ahmed, Elbarazi, Iffat, ElGohary, Ghada Metwally Tawfik, Elhadi, Muhammed, El-Huneidi, Waseem, Elmonem, Mohamed A, Enyew, Daniel Berhanie, Eshetu, Habitu Birhan, Ewald, Samuel B, Ezzeddini, Rana, Fagbamigbe, Adeniyi Francis, Fasanmi, Abidemi Omolara, Fatehizadeh, Ali, Fekadu, Ginenus, Feyisa, Bikila Regassa, Fischer, Florian, Fitzgerald, Ryan, Foroutan, Masoud, Fowobaje, Kayode Raphael, Gadanya, Muktar A, Gaidhane, Abhay Motiramji, Gaihre, Santosh, Gaipov, Abduzhappar, Galali, Yaseen, Galehdar, Nasrin, Garg, Priyanka, Garg, Tushar, Gebremariam, Yosef Haile, Gebremedhin, Ketema Bizuwork, Gebremichael, Berhe, Gela, Yibeltal Yismaw, Gerema, Urge, Getacher, Lemma, Ghaffari, Kazem, Ghafourifard, Mansour, Ghamari, Seyyed-Hadi, Ghasemi Nour, Mohammad, Ghashghaee, Ahmad, Gholamalizadeh, Maryam, Ghozy, Sherief, Gizaw, Abraham Tamirat T, Glasbey, James C, Golechha, Mahaveer, Goleij, Pouya, Golitaleb, Mohamad, Goulart, Alessandra C, Goyomsa, Girma Garedew, Guadie, Habtamu Alganeh, Gubari, Mohammed Ibrahim Mohialdeen, Gudisa, Zewdie, Gunawardane, Damitha Asanga, Gupta, Rahul, Gupta, Rajat Das, Gupta, Sapna, Gupta, Vivek Kumar, Guta, Alemu, Habibzadeh, Parham, Hamidi, Samer, Handal, Alexis J, Hanif, Asif, Hannan, Md Abdul, Harapan, Harapan, Harorani, Mehdi, Hasaballah, Ahmed I, Hasan, Md Mehedi, Hasani, Hamidreza, Hassankhani, Hadi, Hassen, Mohammed Bheser, Hay, Simon I, Hayat, Khezar, Heidari, Golnaz, Hess, Sonja Y, Heyi, Demisu Zenbaba, Hezam, Kamal, Hiraike, Yuta, Holla, Ramesh, Hossain, Sheikh Jamal, Hosseini, Kaveh, Hosseini, Mohammad-Salar, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Huang, Junjie, Hussain, Salman, Hussien, Foziya Mohammed, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Immurana, Mustapha, Inbaraj, Leeberk Raja, Islam, Sheikh Mohammed Shariful, Ismail, Nahlah Elkudssiah, J, Linda Merin, Jamshidi, Elham, Janodia, Manthan Dilipkumar, Jayarajah, Umesh, Jayaram, Shubha, Jebai, Rime, Jemal, Bedru, Jeyakumar, Angeline, Jha, Ravi Prakash, Jonas, Jost B, Joseph, Nitin, Jozwiak, Jacek Jerzy, Kabir, Ali, Kalankesh, Laleh R, Kalhor, Rohollah, Kamal, Vineet Kumar, Kandel, Himal, Kanko, Tesfaye K, Karaye, Ibraheem M, Kashoo, Faizan Zaffar, Katoto, Patrick DMC, Kauppila, Joonas H, Kaur, Harkiran, Kayode, Gbenga A, Kebede, Adera Debella, Keshri, Vikash Ranjan, Keykhaei, Mohammad, Khader, Yousef Saleh, Khajuria, Himanshu, Khalid, Nauman, Khammarnia, Mohammad, Khan, Imteyaz A, Khan, Moien AB, Khatab, Khaled, Khazaei, Zaher, Khubchandani, Jagdish, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Sezer, Kompani, Farzad, Kosen, Soewarta, Koulmane Laxminarayana, Sindhura Lakshmi, Krishan, Kewal, Kuate Defo, Barthelemy, Kuddus, Mohammed, Kumar, G Anil, Kumar, Naveen, Kumar, Nithin, Kurmi, Om P, Kuti, Oluwatosin, Lal, Dharmesh Kumar, Landires, Iván, Larsson, Anders O, Lassi, Zohra S, Latief, Kamaluddin, Laxmaiah, Avula, Ledda, Caterina, Lee, Sang-woong, Legesse, Samson Mideksa, Liu, Xuefeng, Lorenzovici, László, Machado, Vanessa Sintra Machado, Mahajan, Preetam Bhalchandra, Mahjoub, Soleiman, Mahmoodpoor, Ata, Mahmoudi, Elham, Malakan Rad, Elaheh, Mallhi, Tauqeer Hussain, Malta, Deborah Carvalho, Masoudi, Sahar, Masoumi, Seyedeh Zahra, Medina, John Robert Carabeo, Mejia-Rodriguez, Fabiola, Mendes, José João Mendes, Mendoza, Walter, Mendoza-Cano, Oliver, Mentis, Alexios-Fotios A, Meresa, Haftu Asmerom, Mestrovic, Tomislav, Miazgowski, Tomasz, Mirghafourvand, Mojgan, Mirica, Andreea, Mirza, Moonis, Misganaw, Awoke, Misra, Sanjeev, Mohammad, Dara K, Mohammadi, Shadieh, Mohammed, Shafiu, Mohan, Syam, Moka, Nagabhishek, Mokdad, Ali H, Momtazmanesh, Sara, Monasta, Lorenzo, Moni, Mohammad Ali, Moosavi, Delaram, Moradi, Maryam, Mosapour, Abbas, Mostafavi, Ebrahim, Muche, Temesgen, Mulita, Francesk, Mulu, Getaneh Baye, Murray, Christopher J L, Musina, Ana-Maria, Mustafa, Ghulam, Nagarajan, Ahamarshan Jayaraman, Nair, Tapas Sadasivan, Narasimha Swamy, Sreenivas, Nassereldine, Hasan, Natto, Zuhair S, Nayak, Biswa Prakash, Naz, Shumaila, Negoi, Ionut, Negoi, Ruxandra Irina, Nguefack-Tsague, Georges, Ngunjiri, Josephine W, Niazi, Robina Khan, Noori, Maryam, Nowroozi, Ali, Nurrika, Dieta, Nuruzzaman, Khan M, Nzoputam, Ogochukwu Janet, Oancea, Bogdan, Obaidur, Rahman Md, Obsa, Mohammed Mohammed Suleiman Suleiman, Odhiambo, Julius Nyerere, Ogunsakin, Ropo Ebenezer, Okati-Aliabad, Hassan, Okonji, Osaretin Christabel, Oladunjoye, Adeolu Olufunso, Oladunjoye, Olubunmi Omotola, Olagunju, Andrew T, Olufadewa, Isaac Iyinoluwa, Omar Bali, Ahmed, Omonisi, Abidemi E Emmanuel, Ortiz, Alberto, Owolabi, Mayowa O, Padubidri, Jagadish Rao, Pakzad, Reza, Palicz, Tamás, Pandey, Anamika, Pandya, Apurva Kumar, Papadopoulou, Paraskevi, Pardhan, Shahina, Patel, Jay, Pathak, Ashish, Pathan, Aslam Ramjan, Paudel, Rajan, Paudel, Uttam, Pawar, Shrikant, Pereira, Gavin, Perico, Norberto, Perna, Simone, Perumalsamy, Navaraj, Petcu, Ionela-Roxana, Pickering, Brandon V, Piracha, Zahra Zahid, Pollok, Richard Charles G, Pradhan, Pranil Man Singh, Prashant, Akila, Qattea, Ibrahim, Quazi Syed, Zahiruddin, Rahim, Fakher, Rahimi, Mehran, Rahman, Azizur, Rahman, Mohammad Hifz Ur, Rahman, Mosiur, Rahmani, Amir Masoud, Rahmani, Shayan, Rai, Rajesh Kumar, Raimondo, Ivano, Rajaa, Sathish, Ram, Pradhum, Rana, Juwel, Ranjha, Muhammad Modassar Ali Nawaz, Rao, Chythra R, Rao, Sowmya J, Rashedi, Sina, Rashidi, Mohammad-Mahdi, Rawaf, Salman, Rawal, Lal, Raza, Rabail Zehra, Redwan, Elrashdy Moustafa Mohamed, Remuzzi, Giuseppe, Rezaei, Maryam, Rezaei, Nazila, Rezaei, Negar, Richards, Toby, Rickard, Jennifer, Rodriguez, Jefferson Antonio Buendia, Roever, Leonardo, Roshandel, Gholamreza, Roy, Bedanta, Rwegerera, Godfrey M, Saad, Aly M A, Sabour, Siamak, Saddik, Basema, Sadeghi, Malihe, Sadeghian, Saeid, Saeed, Umar, Sahebkar, Amirhossein, Sahoo, Harihar, Salem, Marwa Rashad, Samy, Abdallah M, Sankararaman, Senthilkumar, Santoro, Rocco, Santos, Itamar S, Satpathy, Maheswar, Saya, Ganesh Kumar, Seboka, Binyam Tariku, Senbeta, Anbissa Muleta, Senthilkumaran, Subramanian, Seylani, Allen, Shafeghat, Melika, Shah, Pritik A, Shaikh, Masood Ali, Shanawaz, Mohd, Shannawaz, Mohammed, Sharew, Mequannent Melaku Sharew, Sharma, Purva, Sheikhi, Rahim Ali, Shenoy, Suchitra M, Shetty, Adithi, Shetty, B Suresh Kumar, Shetty, Jeevan K, Shetty, Pavanchand H, Shin, Jae Il, Shivalli, Siddharudha, Shivarov, Velizar, Shobeiri, Parnian, Shorofi, Seyed Afshin, Sikder, Mustafa Kamal, Sima, Ali Reza, Simegn, Wudneh, Singh, Jasvinder A, Singh, Narinder Pal, Singh, Paramdeep, Singh, Surjit, Siraj, Md Shahjahan, Sisay, Yordanos, Skryabina, Anna Aleksandrovna, Solomon, Yonatan, Song, Yi, Sorensen, Reed J D, Stanaway, Jeffrey D, Suchdev, Parminder S, Sufiyan, Mu'awiyyah Babale, Sultana, Saima, Szeto, Mindy D, Tabaeian, Seidamir Pasha, Tahamtan, Alireza, Taheri, Majid, Taheri Soodejani, Moslem, Tamir, Zemenu, Tan, Ker-Kan, Tariqujjaman, Md, Tarkang, Elvis Enowbeyang, Tat, Nathan Y, Tefera, Yibekal Manaye, Temsah, Mohamad-Hani, Thapar, Rekha, Thiyagarajan, Arulmani, Ticoalu, Jansje Henny Vera, Tigabu, Bereket M, Tiyuri, Amir, Tobe-Gai, Ruoyan, Tovani-Palone, Marcos Roberto, Tran, Mai Thi Ngoc, Tusa, Biruk Shalmeno, Ullah, Irfan, Umer, Abdurezak Adem, Unnikrishnan, Bhaskaran, Vacante, Marco, Valadan Tahbaz, Sahel, Valdez, Pascual R, Vart, Priya, Varthya, Shoban Babu, Vaziri, Siavash, Verma, Madhur verma, Veroux, Massimiliano, Vervoort, Dominique, Vu, Linh Gia, Wagaye, Birhanu, Weldegebreal, Fitsum, Wickramasinghe, Nuwan Darshana, Woldemariam, Melat, Wonde, Tewodros Eshete, Wubetie, Gedif Ashebir, Xu, Xiaoyue, Yari, Kheirollah, Yazdanpanah, Fereshteh, Yehualashet, Sisay Shewasinad, Yigit, Arzu, Yiğit, Vahit, Yisihak, Eshetu, Yon, Dong Keon, Yonemoto, Naohiro, Young, Melissa F, Yu, Chuanhua, Yunusa, Ismaeel, Zahir, Mazyar, Zaki, Leila, Zaman, Burhan Abdullah, Zamora, Nelson, Zare, Iman, Zareshahrabadi, Zahra, Zenebe, Getachew Assefa, Zhang, Zhi-Jiang, Zheng, Peng, Zoladl, Mohammad, and Kassebaum, Nicholas J

Published
2023
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23. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study

Author

Kennedy, Stephen H, Victora, Cesar G, Craik, Rachel, Ash, Stephen, Barros, Fernando C, Barsosio, Hellen C, Berkley, James A, Carvalho, Maria, Fernandes, Michelle, Cheikh Ismail, Leila, Lambert, Ann, Lindgren, Cecilia M, McGready, Rose, Munim, Shama, Nellåker, Christoffer, Noble, Julia A, Norris, Shane A, Nosten, Francois, Ohuma, Eric, Papageorghiou, Aris T, Stein, Alan, Stones, William, Tshivuila-Matala, Chrystelle O O, Staines Urias, Eleonora, Vatish, Manu, Wulff, Katharina, Zainab, Ghulam, Zondervan, Krina T, Uauy, Ricardo, Bhutta, Zulfiqar A, Villar, José, Ohuma, Eric O, Jabin, Nusrat, Young, Melissa F, Epie, Terrence, Martorell, Reynaldo, Peña-Rosas, Juan Pablo, Garcia-Casal, Maria Nieves, and Villar, Jose

Published
2023
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24. Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hypertension

Author

Teckman, Jeffrey, Rosenthal, Philip, Hawthorne, Kieran, Spino, Cathie, Bass, Lee M, Murray, Karen F, Kerkar, Nanda, Magee, John C, Karpen, Saul, Heubi, James E, Molleston, Jean P, Squires, Robert H, Kamath, Binita M, Guthery, Stephen L, Loomes, Kathleen M, Sherker, Averell H, Sokol, Ronald J, ChiLDReN, Alonso, Estella, Bass, Lee, Kelly, Susan, Riordan, Mary, Melin-Aldana, Hector, Bezerra, Jorge, Bove, Kevin, Heubi, James, Miethke, Alexander, Tiao, Greg, Denlinger, Julie, Chapman, Erin, Sokol, Ronald, Feldman, Amy, Mack, Cara, Narkewicz, Michael, Suchy, Frederick, Sundaram, Shikha, Van Hove, Johan, Garcia, Benigno, Kauma, Mikaela, Kocher, Kendra, Steinbeiss, Matthew, Lovell, Mark, Loomes, Kathleen, Piccoli, David, Rand, Elizabeth, Russo, Pierre, Spinner, Nancy, Erlichman, Jessi, Stalford, Samantha, Pakstis, Dina, King, Sakya, Squires, Robert, Sindhi, Rakesh, Venkat, Veena, Bukauskas, Kathy, McKiernan, Patrick, Haberstroh, Lori, Squires, James, Bull, Laura, Curry, Joanna, Langlois, Camille, Kim, Grace, Teckman, Jeffery, Kociela, Vikki, Nagy, Rosemary, Patel, Shraddha, Cerkoski, Jacqueline, Bozic, Molly, Subbarao, Girish, Klipsch, Ann, Sawyers, Cindy, Cummings, Oscar, Horslen, Simon, Murray, Karen, Hsu, Evelyn, Cooper, Kara, Young, Melissa, Finn, Laura, Kamath, Binita, Ng, Vicky, Quammie, Claudia, Putra, Juan, Sharma, Deepika, Parmar, Aishwarya, Guthery, Stephen, Jensen, Kyle, Rutherford, Ann, Lowichik, Amy, Book, Linda, Meyers, Rebecka, Hall, Tyler, Wang, Kasper, Michail, Sonia, Thomas, Danny, Goodhue, Catherine, Kohli, Rohit, Wang, Larry, and Soufi, Nisreen

Subjects
Paediatrics, Biomedical and Clinical Sciences, Digestive Diseases, Liver Disease, Pediatric, Hypertension, Clinical Research, Rare Diseases, Transplantation, Chronic Liver Disease and Cirrhosis, 2.1 Biological and endogenous factors, Aetiology, Oral and gastrointestinal, Good Health and Well Being, Adolescent, Adult, Child, Child, Preschool, Cholestasis, Intrahepatic, Disease Progression, Female, Humans, Hypertension, Portal, Infant, Infant, Newborn, Liver Transplantation, Longitudinal Studies, Male, Young Adult, alpha 1-Antitrypsin Deficiency, ChiLDReN, cirrhosis, jaundice, liver enzymes, liver transplant, metabolic liver disease, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectivesTo identify predictors of portal hypertension, liver transplantation, and death in North American youth with alpha-1-antitrypsin (AAT) deficiency, and compare with patients with AAT deficiency elsewhere.Study designThe Childhood Liver Disease Research Network Longitudinal Observational Study of Genetic Causes of Intrahepatic Cholestasis is a prospective, cohort study of pediatric cholestatic liver diseases, including AAT deficiency, enrolling PIZZ and PISZ subjects 0-25 years of age seen since November 2007 at 17 tertiary care centers in the US and Canada. Data from standard-of-care baseline and annual follow-up visits were recorded from medical records, history, physical examination, and laboratory studies. Participants with portal hypertension were identified based on data collected.ResultsWe enrolled 350 participants (60% male) with a native liver; 278 (79%) entered the cohort without portal hypertension and 18 developed portal hypertension during follow-up. Thirty participants required liver transplantation; 2 patients died during 1077 person-years of follow-up. There was no difference in participants with or without preceding neonatal cholestasis progressing to transplantation or death during the study (12% vs 7%; P = .09), or in experiencing portal hypertension (28% vs 21%; P = .16); the hazard ratio for neonatal cholestasis leading to portal hypertension was P = .04. Development of portal hypertension was associated with a reduced height Z-score.ConclusionsPortal hypertension in youth with AAT deficiency impacts growth measures. Progression to liver transplantation is slow and death is rare, but the risk of complications and severe liver disease progression persists throughout childhood. A history of neonatal cholestasis is a weak predictor of severe disease.

Published
2020

25. Incidence of Type 2 Diabetes in Children With Nonalcoholic Fatty Liver Disease

Author

Garner, Donna, Hertel, Paula, Lawson, Alicia, Pham, Yen, Triggs, Nicole, Bramlage, Kristin, Carr, April, McNeill, Meghan, Mouzaki, Marialena, Xanthakos, Stavra, Alazraki, Adina, Cleeton, Rebecca, Cordero, Maria, Karpen, Saul, Vos, Miriam, Carr, Laura, Cummings, Oscar W., Harlow, Kathryn, Klipsch, Ann, Molleston, Jean P., Morlan, Wendy, Ragozzino, Emily, Sawyers, Cindy, Anthony, Angela, Fishbein, Mark H., Cattoor, Theresa, Freebersyser, Janet, Jain, Ajay K., Torretta, Susan, Behling, Cynthia, Durelle, Janis, Goyal, Nidhi P., Newton, Kimberly P., Schwimmer, Jeffrey B., Ugalde-Nicalo, Patricia, Wang, Andrew, Blondet, Niviann, Cooper, Kara, Otto, Randolph, Yeh, Matthew, Young, Melissa, Kleiner, David E., Doo, Edward C., Hall, Sherry, Hoofnagle, Jay H., Sherker, Averell H., Torrance, Rebecca, Robuck, Patricia R., Adamo, Peggy, Belt, Patricia, Clark, Jeanne M., Meinert, Jill, Miriel, Laura, Shade, Carrie, Sharkey, Emily P., Smith, Jacqueline, Smith, Michael, Sternberg, Alice, Tonascia, ScM; James, Van Natta, Mark L., Wagoner, Annette, Wilson, Laura A., Woreta, Tinsay, Yates, Katherine P., Dodge, John, Donithan, Michele, Isaacson, Milana, Crimmins, Nancy A., and Xanthakos, Stavra A.

Published
2023
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26. Intraindividual double burden of overweight or obesity and micronutrient deficiencies or anemia among women of reproductive age in 17 population-based surveys

Author

Williams, Anne M, Guo, Junjie, Addo, O Yaw, Ismaily, Sanober, Namaste, Sorrel ML, Oaks, Brietta M, Rohner, Fabian, Suchdev, Parminder S, Young, Melissa F, Flores-Ayala, Rafael, and Engle-Stone, Reina

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Nutrition, Obesity, Hematology, Zero Hunger, Adolescent, Adult, Age Factors, Anemia, Biomarkers, Body Mass Index, Comorbidity, Deficiency Diseases, Female, Global Health, Humans, Income, Logistic Models, Micronutrients, Nutritional Status, Overweight, Poverty, Prevalence, Social Class, Surveys and Questionnaires, Young Adult, double burden of malnutrition, women, anemia, over-weight/obesity, micronutrients, overweight/obesity, Engineering, Medical and Health Sciences, Nutrition & Dietetics, Clinical sciences, Nutrition and dietetics
Abstract

BackgroundRising prevalence of overweight/obesity (OWOB) alongside persistent micronutrient deficiencies suggests many women face concomitant OWOB and undernutrition.ObjectivesWe aimed to 1) describe the prevalence of the double burden of malnutrition (DBM) among nonpregnant women of reproductive age, defined as intraindividual OWOB and either ≥1 micronutrient deficiency [micronutrient deficiency index (MDI) > 0; DBM-MDI] or anemia (DBM-anemia); 2) test whether the components of the DBM were independent; and 3) identify factors associated with DBM-MDI and DBM-anemia.MethodsWith data from 17 national surveys spanning low- and middle-income countries (LMICs) and high-income countries from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia project (n = 419 to n = 9029), we tested independence of over- and undernutrition using the Rao-Scott chi-square test and examined predictors of the DBM and its components using logistic regression for each survey.ResultsMedian DBM-MDI was 21.9% (range: 1.6%-39.2%); median DBM-anemia was 8.6% (range: 1.0%-18.6%). OWOB and micronutrient deficiencies or anemia were independent in most surveys. Where associations existed, OWOB was negatively associated with micronutrient deficiencies and anemia in LMICs. In 1 high-income country, OWOB women were more likely to experience micronutrient deficiencies and anemia. Age was consistently positively associated with OWOB and the DBM, whereas the associations with other sociodemographic characteristics varied. Higher socioeconomic status tended to be positively associated with OWOB and the DBM in LMICs, whereas in higher-income countries the association was reversed.ConclusionsThe independence of OWOB and micronutrient deficiencies or anemia within individuals suggests that these forms of over- and undernutrition may have unique etiologies. Decision-makers should still consider the prevalence, consequences, and etiology of the individual components of the DBM as programs move towards double-duty interventions aimed at addressing OWOB and undernutrition simultaneously.

Published
2020

27. Association between anemia and household water source or sanitation in preschool children: the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

Author

Yu, Emma X, Addo, O Yaw, Williams, Anne M, Engle-Stone, Reina, Ou, Jiangda, Huang, Weixing, Guo, Junjie, Suchdev, Parminder S, and Young, Melissa F

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Clinical Sciences, Clinical Research, Hematology, Clean Water and Sanitation, Anemia, Bangladesh, Biomarkers, Burkina Faso, Child, Preschool, Cross-Sectional Studies, Female, Global Health, Hemoglobins, Humans, Infant, Inflammation, Kenya, Malaria, Male, Nicaragua, Philippines, Sanitation, Water, Water Supply, anemia, water, sanitation, complex survey, preschool children, BRINDA, Engineering, Medical and Health Sciences, Nutrition & Dietetics, Clinical sciences, Nutrition and dietetics
Abstract

BackgroundThe associations between anemia and household water source and sanitation remain unclear.ObjectivesWe aimed to assess the associations between anemia and household water source or sanitation in preschool children (PSC; age 6-59 mo) using population-based surveys from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.MethodsWe analyzed national and subnational data from 21 surveys, representing 19 countries (n = 35,963). Observations with hemoglobin (Hb) and ≥1 variable reflecting household water source or sanitation were included. Anemia was defined as an altitude-adjusted Hb concentration

Published
2020

28. Stage III uterine serous carcinoma: modern trends in multimodality treatment

Author

Li, Jessie Y, Young, Melissa R, Huang, Gloria, Litkouhi, Babak, Santin, Alessandro, Schwartz, Peter E, and Damast, Shari

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Cancer, Adult, Aged, Aged, 80 and over, Brachytherapy, Endometrial Neoplasms, Female, Humans, Hysterectomy, Middle Aged, Neoplasm Staging, Radiotherapy, Adjuvant, Retrospective Studies, Endometrium, Carcinoma, Radiotherapy, Paediatrics and Reproductive Medicine, Oncology and carcinogenesis, Reproductive medicine
Abstract

ObjectiveTo examine outcomes in a modern treatment era for stage III uterine serous carcinoma (USC).MethodsFifty women were retrospectively identified as 2009 International Federation of Gynecology and Obstetrics stage III USC patients who received radiotherapy (RT) at our institution between 1/2003-5/2018. The patients were divided into 2 cohorts: 20 in the early era (2003-2010) and 30 in the modern era (2011-2018). Patient characteristics were compared using χ² tests for categorical variables and t-tests for continuous variables. Recurrence free survival (RFS) and overall survival (OS) were analyzed with Kaplan-Meier estimates, the log-rank test, and Cox proportional hazards.ResultsThe modern era differed from the early era in the increased use of volume-directed external beam RT (EBRT) as opposed to vaginal brachytherapy (VB) alone (33.3% vs 5.0%, p=0.048), minimally invasive surgery (56.7% vs. 25%, p=0.027), sentinel node sampling (26.7% vs. 0%, p=0.012), computed tomography imaging in the perioperative period (63.3% vs. 30%, p=0.044), and human epidermal growth factor receptor 2/neu testing (96.7% vs. 55%, p=0.001). Median follow-up for early and modern eras was 37.27 and 33.23 months, respectively. The early vs. modern 3-year RFS was 33% and 64% (p=0.039), respectively, while the 3-year OS was 55% and 90% (p=0.034). Regional nodal recurrence more common among the patients who received VB only (p=0.048).ConclusionModern era treatment was associated with improved RFS and OS in patients with stage III USC. Regional nodal recurrences were significantly reduced in patients who received EBRT.

Published
2020

31. Micronutrient deficiencies among preschool-aged children and women of reproductive age worldwide: a pooled analysis of individual-level data from population-representative surveys

Author

Addo, O Yaw, Adu-Afarwuah, Seth, Alayón, Silvia, Bhutta, Zulfiqar, Brown, Kenneth H, Jefferds, Maria Elena, Engle-Stone, Reina, Fawzi, Wafaie, Hess, Sonja Y, Johnston, Robert, Katz, Joanne, Krasevec, Julia, McDonald, Christine M, Mei, Zuguo, Osendarp, Saskia, Paciorek, Christopher J, Petry, Nicolai, Pfeiffer, Christine M, Ramirez-Luzuriaga, Maria J, Rogers, Lisa M, Rohner, Fabian, Sethi, Vani, Suchdev, Parminder S, Tessema, Masresha, Villapando, Salvador, Wieringa, Frank T, Williams, Anne M, Woldeyahannes, Meseret, Young, Melissa F, Stevens, Gretchen A, Beal, Ty, Mbuya, Mduduzi N N, Luo, Hanqi, and Neufeld, Lynnette M

Published
2022
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32. Maternal hemoglobin concentrations across pregnancy and maternal and child health: a systematic review and meta‐analysis

Author

Young, Melissa F, Oaks, Brietta M, Tandon, Sonia, Martorell, Reynaldo, Dewey, Kathryn G, and Wendt, Amanda S

Subjects
Biomedical and Clinical Sciences, Midwifery, Public Health, Health Sciences, Reproductive Medicine, Contraception/Reproduction, Hematology, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Infant Mortality, Preterm, Low Birth Weight and Health of the Newborn, Clinical Research, Reproductive health and childbirth, Good Health and Well Being, Child Health, Female, Hemoglobins, Humans, Infant, Small for Gestational Age, Maternal Health, Obstetric Labor Complications, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Premature Birth, hemoglobin, anemia, pregnancy, review, birth outcomes, General Science & Technology
Abstract

Maternal anemia is a well-recognized global health problem; however, there remain questions on specific hemoglobin (Hb) thresholds that predict health risk or protection for mother and child. We conducted a systematic review and meta-analysis to examine the associations of maternal Hb concentrations with a range of maternal and infant health outcomes, accounting for the timing of measurement (preconception, and first, second, and third trimesters), etiology of anemia, and cutoff category. The systematic review included 272 studies and the meta-analysis included 95 studies. Low maternal Hb (130 g/L) was associated with increased odds of SGA, stillbirth, preeclampsia, and gestational diabetes. Relationships varied by the timing of measurement and cutoff category (stronger associations with lower cutoffs); limited data were available on anemia etiology. There were insufficient data for other maternal outcomes and long-term child health outcomes. Current data are insufficient for determining if revisions to current Hb cutoffs are required. Pooled high-quality individual-level data analyses, as well as prospective cohort studies, would be valuable to inform the reevaluation of Hb cutoffs.

Published
2019

38. Identifying Opportunities to Deliver High‐Quality Cancer Care Across a Health System: A Clinical Responsibility.

Author

Shah, Hemali P., Cohen, Oded, Bourdillon, Alexandra T., Burtness, Barbara A., Boffa, Daniel J., Young, Melissa, Judson, Benjamin L., and Mehra, Saral

Abstract

Objective: We examined process‐related quality metrics for oral squamous cell carcinoma (OSCC) depending on treating facility type across a health system and region. Study Design: Retrospective in accordance with Strengthening the Reporting of Observational Studies in Epidemiology guidelines. Setting: Single health system and region. Methods: Patients with OSCC diagnosed between 2012 and 2018 were identified from tumor registries of 6 hospitals (1 academic and 5 community) within a single health system. Patients were categorized into 3 care groups: (1) solely at the academic center, (2) solely at community facilities, and (3) combined care at academic and community facilities. Primary outcome measures were process‐related quality metrics: positive surgical margin rate, lymph node yield (LNY), adjuvant treatment initiation ≤6 weeks, National Comprehensive Cancer Network (NCCN)‐guideline adherence. Results: A total of 499 patients were included: 307 (61.5%) patients in the academic‐only group, 101 (20.2%) in the community‐only group, and 91 (18.2%) in the combined group. Surgery at community hospitals was associated with increased odds of positive surgical margins (11.9% vs 2.5%, odds ratio [OR]: 47.73, 95% confidence interval [CI]: 11.2‐275.86, P <.001) and lower odds of LNY ≥ 18 (52.8% vs 85.9%, OR: 0.15, 95% CI: 0.07‐0.33, P <.001) relative to the academic center. Compared with the academic‐only group, odds of adjuvant treatment initiation ≤6 weeks were lower for the combined group (OR: 0.30, 95% CI: 0.13‐0.64, P =.002) and odds of NCCN guideline‐adherent treatment were lower in the community only group (OR: 0.35, 95% CI: 0.18‐0.70, P =.003). Conclusion: Quality of oral cancer care across the health system and region is comparable to or better‐than national standards, indicating good baseline quality of care. Differences by facility type and fragmentation of care present an opportunity for bringing best in‐class cancer care across an entire region. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease

Author

Harlow, Kathryn E, Africa, Jonathan A, Wells, Alan, Belt, Patricia H, Behling, Cynthia A, Jain, Ajay K, Molleston, Jean P, Newton, Kimberly P, Rosenthal, Philip, Vos, Miriam B, Xanthakos, Stavra A, Lavine, Joel E, Schwimmer, Jeffrey B, Network, Nonalcoholic Steatohepatitis Clinical Research, Abrams, Stephanie H, Barlow, Sarah, Himes, Ryan, Krisnamurthy, Rajesh, Maldonado, Leanel, Mahabir, Rory, Carr, April, Bernstein, Kimberlee, Bramlage, Kristin, Cecil, Kim, DeVore, Stephanie, Kohli, Rohit, Lake, Kathleen, Podberesky, Daniel, Towbin, Alex, Behr, Gerald, Lefkowitch, Jay H, Mencin, Ali, Reynoso, Elena, Alazraki, Adina, Cleeton, Rebecca, Cordero, Maria, Hernandez, Albert, Karpen, Saul, Munos, Jessica Cruz, Raviele, Nicholas, Bozic, Molly, Cummings, Oscar W, Klipsch, Ann, Ragozzino, Emily, Sandrasegaran, Kumar, Subbarao, Girish, Walker, Laura, Kafka, Kimberly, Scheimann, Ann, Ito, Joy, Fishbein, Mark H, Mohammad, Saeed, Rigsby, Cynthia, Sharda, Lisa, Whitington, Peter F, Cattoor, Theresa, Derdoy, Jose, Freebersyser, Janet, King, Debra, Lai, Jinping, Osmack, Pat, Siegner, Joan, Stewart, Susan, Torretta, Susan, Wriston, Kristina, Baker, Susan S, Lopez-Graham, Diana, Williams, Sonja, Zhu, Lixin, Awai, Hannah, Bross, Craig, Collins, Jennifer, Durelle, Janis, Middleton, Michael, Paiz, Melissa, Sirlin, Claude, Ugalde-Nicalo, Patricia, Villarreal, Mariana Dominguez, Aouizerat, Bradley, Courtier, Jesse, Ferrell, Linda D, Feier, Natasha, Gill, Ryan, Langlois, Camille, Perito, Emily Rothbaum, Tsai, Patrika, Cooper, Kara, Horslen, Simon, Hsu, Evelyn, Murray, Karen, Otto, Randolph, Yeh, Matthew, Young, Melissa, Brunt, Elizabeth M, Fowler, Kathryn, Kleiner, David E, Brown, Sherry, Doo, Edward C, and Hoofnagle, Jay H

Subjects
Paediatrics, Biomedical and Clinical Sciences, Pediatric, Chronic Liver Disease and Cirrhosis, Cardiovascular, Health Disparities, Obesity, Minority Health, Prevention, Liver Disease, Digestive Diseases, Nutrition, 2.4 Surveillance and distribution, Metabolic and endocrine, Good Health and Well Being, Child, Cholesterol, LDL, Diet, Female, Humans, Hypercholesterolemia, Hypertriglyceridemia, Life Style, Longitudinal Studies, Male, Non-alcoholic Fatty Liver Disease, Triglycerides, Nonalcoholic Steatohepatitis Clinical Research Network, NAFLD, cardiovascular, diet, dyslipidemia, pediatric, statin, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo determine the percentage of children with nonalcoholic fatty liver disease (NAFLD) in whom intervention for low-density lipoprotein cholesterol or triglycerides was indicated based on National Heart, Lung, and Blood Institute guidelines.Study designThis multicenter, longitudinal cohort study included children with NAFLD enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Nonalcoholic Steatohepatitis Clinical Research Network. Fasting lipid profiles were obtained at diagnosis. Standardized dietary recommendations were provided. After 1 year, lipid profiles were repeated and interpreted according to National Heart, Lung, and Blood Institute Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction. Main outcomes were meeting criteria for clinically actionable dyslipidemia at baseline, and either achieving lipid goal at follow-up or meeting criteria for ongoing intervention.ResultsThere were 585 participants, with a mean age of 12.8 years. The prevalence of children warranting intervention for low-density lipoprotein cholesterol at baseline was 14%. After 1 year of recommended dietary changes, 51% achieved goal low-density lipoprotein cholesterol, 27% qualified for enhanced dietary and lifestyle modifications, and 22% met criteria for pharmacologic intervention. Elevated triglycerides were more prevalent, with 51% meeting criteria for intervention. At 1 year, 25% achieved goal triglycerides with diet and lifestyle changes, 38% met criteria for advanced dietary modifications, and 37% qualified for antihyperlipidemic medications.ConclusionsMore than one-half of children with NAFLD met intervention thresholds for dyslipidemia. Based on the burden of clinically relevant dyslipidemia, lipid screening in children with NAFLD is warranted. Clinicians caring for children with NAFLD should be familiar with lipid management.

Published
2018

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