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3. NF-M is an essential target for the myelin-directed “outside-in” signaling cascade that mediates radial axonal growth

Author

Garcia, Michael L, Lobsiger, Christian S, Shah, Sameer B, Deerinck, Tom J, Crum, John, Young, Darren, Ward, Christopher M, Crawford, Thomas O, Gotow, Takahiro, Uchiyama, Yasuo, Ellisman, Mark H, Calcutt, Nigel A, and Cleveland, Don W

Subjects
Biochemistry and Cell Biology, Biological Sciences, Genetics, Neurosciences, Underpinning research, 1.1 Normal biological development and functioning, Neurological, Action Potentials, Amino Acid Motifs, Animals, Axons, Mice, Mice, Transgenic, Models, Biological, Motor Activity, Myelin Sheath, Nerve Fibers, Myelinated, Neurofilament Proteins, Phosphorylation, Protein Structure, Tertiary, Protein Subunits, Signal Transduction, myelin, neurofilaments, phosphorylation, axon caliber, radial growth, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Neurofilaments are essential for acquisition of normal axonal calibers. Several lines of evidence have suggested that neurofilament-dependent structuring of axoplasm arises through an "outside-in" signaling cascade originating from myelinating cells. Implicated as targets in this cascade are the highly phosphorylated KSP domains of neurofilament subunits NF-H and NF-M. These are nearly stoichiometrically phosphorylated in myelinated internodes where radial axonal growth takes place, but not in the smaller, unmyelinated nodes. Gene replacement has now been used to produce mice expressing normal levels of the three neurofilament subunits, but which are deleted in the known phosphorylation sites within either NF-M or within both NF-M and NF-H. This has revealed that the tail domain of NF-M, with seven KSP motifs, is an essential target for the myelination-dependent outside-in signaling cascade that determines axonal caliber and conduction velocity of motor axons.

Published
2003

6. IN TOUCH.

Author

Jenkins, George, Parfitt, Gareth, Mcluskie, David, Young, Darren, Rodriguez, John, De Regge, Ruben, Belcher, Malcolm, Addison, Liz, Cronin, Rhydian, and Watson, David

Published
2019

7. laughing gas.

Author

McDacy, Mark, Millheim, Terry, Muhlheim, Chris, Young, Darren, and Steyns, Rebecca

Subjects
WIT & humor, DOG walking, OLDER women, YOUNG men, ARITHMETIC
Abstract

Several jokes are presented including one about a girl who takes the dog for a walk, one about an old woman who was on trial for shooting a young man and one about a boy who got an F rating in arithmetic.

Published
2009

8. LAUGHING GAS.

Author

Young, Darren, England, Bruce, Harvey, D, and McDermott, Shelley

Subjects
WIT & humor, BODYBUILDERS
Abstract

Several jokes are presented, including one about a bodybuilder and a blonde.

Published
2007

9. TECH TIPS.

Author

Young, Darren, McCuistian, Richard, Conaway, Gene, and Gordon, Jacques

Subjects
AUTOMOBILE engine maintenance & repair, AUTOMATIC automobile transmissions, INJECTORS, REPAIRING, AUTOMOBILE engines
Abstract

Gives advice on repairing and maintaining automobile engines. Tips on installing injectors for automatic transmission engines; Reasons behind the occurrence of voltage drops in alternators.

Published
2005

10. LETTERS.

Author

Archer, Ben, Hubbard, John, Adams, J. T., Young, Darren, Fauver, Robert, and Robbins, Christopher

Subjects
LETTERS to the editor, POSTERS, LETTERING, TYPOGRAPHIC design, GRAPHIC designers
Abstract

Several letters to the editor are presented in response to the article in previous issues including the Artcity 2005 poster El Oltro Lado by Denise Gonzales, another on Jurg Lehni's Scriptographer by David Womack, and a profile of Alex McDowell.

Published
2006

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