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2,194 results on '"Young, Bob"'

2. Contents

Author

Young, F. Ronald and Young, Bob

Published
2011

3. Preface

Author

Young, F. Ronald and Young, Bob

Published
2011

8. References

Author

Young, F. Ronald and Young, Bob

Published
2011

9. Glossary

Author

Young, F. Ronald and Young, Bob

Published
2011

11. Index

Author

Young, F. Ronald and Young, Bob

Published
2011

15. Epilogue

Author

Young, F. Ronald and Young, Bob

Published
2011

16. Image Plates

Author

Young, F. Ronald and Young, Bob

Published
2011

17. Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK

Author

Lone, Nazir, Baillie, Kenneth, Pairo-Castineira, Erola, Avramidis, Nikos, Wain, Louise, Guillen-Guio, Beatriz, Leavy, Olivia, Jones, S, Armstrong, Lisa, Hairsine, Brigid, Henson, Helen, Kurasz, Claire, Shaw, Alison, Shenton, Liz, Dobson, Hannah, Dell, Amanda, Fairbairn, Sara, Hawkings, Nancy, Haworth, Jill, Hoare, Michaela, Lewis, Victoria, Lucey, Alice, Mallison, Georgia, Nassa, Heeah, Pennington, Chris, Price, Andrea, Price, Claire, Storrie, Andrew, Willis, Gemma, Young, Susan, Poinasamy, Krisnah, Walker, Samantha, Jarrold, Ian, Rawlik, Konrad, Sanderson, Amy, Chong-James, K, David, C, James, W Y, Pfeffer, Paul, Zongo, O, Martineau, Adrian, Manisty, C, Armour, Cherie, Brown, Vanessa, Busby, John, Connolly, Bronwen, Craig, Thelma, Drain, Stephen, Heaney, Liam, King, Bernie, Magee, Nick, Major, E, McAulay, Danny, McGarvey, Lorcan, McGinness, Jade, Peto, Tunde, Stone, Roisin, Bolger, Annette, Davies, Ffyon, Haggar, Ahmed, Lewis, Joanne, Lloyd, Arwel, Manley, R, McIvor, Emma, Menzies, Daniel, Roberts, K, Saxon, W, Southern, David, Subbe, Christian, Whitehead, Victoria, Bularga, Anda, Mills, Nicholas, Dawson, Joy, El-Taweel, Hosni, Robinson, Leanne, Brear, Lucy, Regan, Karen, Saralaya, Dinesh, Storton, Kim, Amoils, Shannon, Bermperi, Areti, Cruz, Isabel, Dempsey, K, Elmer, Anne, Fuld, Jonathon, Jones, H, Jose, Sherly, Marciniak, Stefan, Parkes, M, Ribeiro, Carla, Taylor, Jessica, Toshner, Mark, Watson, L, Worsley, J, Broad, Lauren, Evans, Teriann, Haynes, Matthew, Jones, L, Knibbs, Lucy, McQueen, Alison, Oliver, Catherine, Paradowski, Kerry, Sabit, Ramsey, Williams, Jenny, Jones, Ian, Milligan, Lea, Harris, Edward, Sampson, Claire, Davies, Ellie, Evenden, Cerys, Hancock, Alyson, Hancock, Kia, Lynch, Ceri, Rees, Meryl, Roche, Lisa, Stroud, Natalie, Thomas-Woods, T, Heller, Simon, Chalder, Trudie, Shah, Kamini, Robertson, Elizabeth, Young, Bob, Babores, Marta, Holland, Maureen, Keenan, Natalie, Shashaa, Sharlene, Wassall, Helen, Austin, Liam, Beranova, Eva, Cosier, Tracey, Deery, Joanne, Hazelton, Tracy, Price, Carly, Ramos, Hazel, Solly, Reanne, Turney, Sharon, Weston, Heather, Coughlan, Eamon, Ralser, Markus, Pearce, Lorraine, Pugmire, S, Stoker, Wendy, Wilson, Ann, McCormick, W, Fraile, Eva, Ugoji, Jacinta, Aguilar Jimenez, Laura, Arbane, Gill, Betts, Sarah, Bisnauthsing, Karen, Dewar, A, Hart, Nicholas, Kaltsakas, G, Kerslake, Helen, Magtoto, Murphy, Marino, Philip, Martinez, L M, Ostermann, Marlies, Rossdale, Jennifer, Solano, Teresa, Alvarez Corral, Maria, Arias, Ava Maria, Bevan, Emily, Griffin, Denise, Martin, Jane, Owen, J, Payne, Sheila, Prabhu, A, Reed, Annabel, Storrar, Will, Williams, Nick, Wrey Brown, Caroline, Burdett, Tracy, Featherstone, James, Lawson, Cathy, Layton, Alison, Mills, Clare, Stephenson, Lorraine, Ellis, Yvette, Atkin, Paul, Brindle, K, Crooks, Michael, Drury, Katie, Easom, Nicholas, Flockton, Rachel, Holdsworth, L, Richards, A, Sykes, D L, Thackray-Nocera, Susannah, Wright, C, Coetzee, S, Davies, Kim, Hughes, Rachel Ann, Loosley, Ronda, McGuinness, Heather, Mohamed, Abdelrahman, O'Brien, Linda, Omar, Zohra, Perkins, Emma, Phipps, Janet, Ross, Gavin, Taylor, Abigail, Tench, Helen, Wolf-Roberts, Rebecca, Burden, L, Calvelo, Ellen, Card, Bethany, Carr, Caitlin, Chilvers, Edwin, Copeland, Donna, Cullinan, P, Daly, Patrick, Evison, Lynsey, Fayzan, Tamanah, Gordon, Hussain, Haq, Sulaimaan, Jenkins, Gisli, King, Clara, Kon, Onn Min, March, Katherine, Mariveles, Myril, McLeavey, Laura, Mohamed, Noura, Moriera, Silvia, Munawar, Unber, Nunag, Jose Lloyd, Nwanguma, Uchechi, Orriss-Dib, Lorna, Ross, Alexandra, Roy, Maura, Russell, Emily, Samuel, Katherine, Schronce, J, Simpson, Neil, Tarusan, Lawrence, Thomas, David, Wood, Chloe, Yasmin, Najira, Altmann, Danny, Howard, Luke, Johnston, Desmond, Lingford-Hughes, Anne, Man, William, Mitchell, Jane, Molyneaux, Philip, Nicolaou, Christos, O'Regan, D P, Price, L, Quint, Jenni, Smith, David, Thwaites, Ryan, Valabhji, Jonathon, Walsh, Simon, Efstathiou, Claudia, Liew, Felicity, Frankel, Anew, Lightstone, Liz, McAdoo, Steve, Wilkins, Martin, Willicombe, Michelle, Touyz, R, Guerdette, Anne-Marie, Hewitt, Melanie, Reddy, R, Warwick, Katie, White, Sonia, McMahon, Aisling, Adeyemi, Oluwaseun, Adrego, Rita, Assefa-Kebede, Hosanna, Breeze, Jonathon, Byrne, S, Dulawan, Pearl, Hoare, Amy, Jolley, Caroline, Knighton, Abigail, Patale, Sheetal, Peralta, Ida, Powell, Natassia, Ramos, Albert, Shevket, K, Speranza, Fabio, Te, Amelie, Malim, M, Bramham, Kate, Brown, M, Ismail, Khalida, Nicholson, Tim, Pariante, Carmen, Sharpe, Claire, Wessely, Simon, Whitney, J, Shah, Ajay, Chiribiri, A, O'Brien, C, Hayday, A, Ashworth, Andrew, Beirne, Paul, Clarke, Jude, Coupland, C, Dalton, Matthhew, Favager, Clair, Glossop, Jodie, Greenwood, John, Hall, Lucy, Hardy, Tim, Humphries, Amy, Murira, Jennifer, Peckham, Dan, Plein, S, Rangeley, Jade, Saalmink, Gwen, Tan, Ai Lyn, Wade, Elaine, Whittam, Beverley, Window, Nicola, Woods, Janet, Coakley, G, Turtle, Lance, Allerton, Lisa, Allt, Ann Marie, Beadsworth, M, Berridge, Anthony, Brown, Jo, Cooper, Shirley, Cross, Andy, Defres, Sylviane, Dobson, S L, Earley, Joanne, French, N, Greenhalf, William, Hainey, Kera, Hardwick, Hayley, Hawkes, Jenny, Highett, Victoria, Kaprowska, Sabina, Key, Angela, Lavelle-Langham, Lara, Lewis-Burke, N, Madzamba, Gladys, Malein, Flora, Marsh, Sophie, Mears, Chloe, Melling, Lucy, Noonan, Matthew, Poll, L, Pratt, James, Richardson, Emma, Rowe, Anna, Semple, Calum, Shaw, Victoria, Tripp, K A, Wajero, Lilian, Williams-Howard, S A, Wootton, Dan, Wyles, J, Diwanji, Shalin, Gurram, Sambasivarao, Papineni, Padmasayee, Quaid, Sheena, Tiongson, Gerlynn, Watson, Ekaterina, Briggs, Andrew, Marks, Michael, Hastie, Claire, Rogers, Natalie, Smith, Nikki, Stensel, David, Bishop, Lettie, McIvor, Katherine, Rivera-Ortega, Pilar, Al-Sheklly, Bashar, Avram, Cristina, Blaikely, John, Buch, M, Choudhury, N, Faluyi, David, Felton, T, Gorsuch, T, Hanley, Neil, Horsley, Alex, Hussell, Tracy, Kausar, Zunaira, Odell, Natasha, Osbourne, Rebecca, Piper Hanley, Karen, Radhakrishnan, K, Stockdale, Sue, Kabir, Thomas, Scott, Janet, Stewart, Iain, Openshaw, Peter, Burn, David, Ayoub, A, Brown, J, Burns, G, Davies, Gareth, De Soyza, Anthony, Echevarria, Carlos, Fisher, Helen, Francis, C, Greenhalgh, Alan, Hogarth, Philip, Hughes, Joan, Jiwa, Kasim, Jones, G, MacGowan, G, Price, D, Sayer, Avan, Simpson, John, Tedd, H, Thomas, S, West, Sophie, Witham, M, Wright, S, Young, A, McMahon, Michael, Neill, Paula, Anderson, David, Basu, Neil, Bayes, Hannah, Brown, Ammani, Dougherty, Andrew, Fallon, K, Gilmour, L, Grieve, D, Mangion, K, Morrow, A, Sykes, R, Berry, Colin, McInnes, I B, Scott, Kathryn, Barrett, Fiona, Donaldson, A, Sage, Beth, Bell, Murdina, Brown, Angela, Hamil, R, Leitch, Karen, Macliver, L, Patel, Manish, Quigley, Jackie, Smith, Andrew, Welsh, B, Choudhury, Gaunab, Clohisey, S, Deans, Andrew, Docherty, Annemarie, Furniss, J, Harrison, Ewen, Kelly, S, Sheikh, Aziz, Chalmers, James, Connell, David, Deas, C, Elliott, Anne, George, J, Mohammed, S, Rowland, J, Solstice, AR, Sutherland, Debbie, Tee, Caroline, Bunker, Jenny, Gill, Rhyan, Nathu, Rashmita, Holmes, Katie, Adamali, H, Arnold, David, Barratt, Shaney, Dipper, A, Dunn, Sarah, Maskell, Nick, Morley, Anna, Morrison, Leigh, Stadon, Louise, Waterson, Samuel, Welch, H, Jayaraman, Bhagy, Light, Tessa, Vogiatzis, Ioannis, Almeida, Paula, Bolton, Charlotte, Hosseini, Akram, Matthews, Laura, Needham, Robert, Shaw, Karen, Thomas, Andrew, Bonnington, J, Chrystal, Melanie, Dupont, Catherine, Greenhaff, Paul, Gupta, Ayushman, Jang, W, Linford, S, Nikolaidis, Athanasios, Prosper, Sabrina, Burns, A, Kanellakis, N, Ferreira, V, Nikolaidou, C, Xie, C, Ainsworth, Mark, Alamoudi, Asma, Bloss, Angela, Carter, Penny, Cassar, M, Chen, Jin, Conneh, Florence, Dong, T, Evans, Ranuromanana, Fraser, Emily, Geddes, John, Gleeson, F, Harrison, Paul, Havinden-Williams, May, Ho, Ling Pei, Jezzard, P, Koychev, Ivan, Kurupati, Prathiba, McShane, H, Megson, Clare, Neubauer, Stefan, Nicoll, Debby, Ogg, G, Pacpaco, Edmund, Pavlides, M, Peng, Yanchun, Petousi, Nayia, Pimm, John, Rahman, Najib, Raman, Betty, Rowland, M J, Saunders, Kathryn, Sharpe, Michael, Talbot, Nick, Tunnicliffe, E M, Korszun, Ania, Kerr, Steven, Barker, R E, Cristiano, Daniele, Dormand, N, George, P, Gummadi, Mahitha, Kon, S, Liyanage, Kamal, Nolan, C M, Patel, B, Patel, Suhani, Polgar, Oliver, Shah, P, Singh, Suver, Walsh, J A, Gibbons, Michael, Ahmad, Shanaz, Brill, Simon, Hurst, John, Jarvis, Hannah, Lim, Lai, Mandal, S, Matila, Darwin, Olaosebikan, Olaoluwa, Singh, Claire, Laing, C, Baxendale, Helen, Garner, Lucie, Johnson, C, Mackie, J, Michael, Alice, Newman, J, Pack, Jamie, Paques, K, Parfrey, H, Parmar, J, Reddy, A, Halling-Brown, Mark, Dark, P, Diar-Bakerly, Nawar, Evans, D, Hardy, E, Harvey, Alice, Holgate, D, Knight, Sean, Mairs, N, Majeed, N, McMorrow, L, Oxton, J, Pendlebury, Jessica, Summersgill, C, Ugwuoke, R, Whittaker, S, Matimba-Mupaya, Wadzanai, Strong-Sheldrake, Sophia, Chowienczyk, Phillip, Bagshaw, J, Begum, M, Birchall, K, Butcher, Robyn, Carborn, H, Chan, Flora, Chapman, Kerry, Cheng, Yutung, Chetham, Luke, Clark, Cameron, Coburn, Zach, Cole, Joby, Dixon, Myles, Fairman, Alexandra, Finnigan, J, Foot, H, Foote, David, Ford, Amber, Gregory, Rebecca, Harrington, Kate, Haslam, L, Hesselden, L, Hockridge, J, Holbourn, Ailsa, Holroyd-Hind, B, Holt, L, Howell, Alice, Hurditch, E, Ilyas, F, Jarman, Claire, Lawrie, Allan, Lee, Ju Hee, Lee, Elvina, Lenagh, Rebecca, Lye, Alison, Macharia, Irene, Marshall, M, Mbuyisa, Angeline, McNeill, J, Megson, Sharon, Meiring, J, Milner, L, Misra, S, Newell, Helen, Newman, Tom, Norman, C, Nwafor, Lorenza, Pattenadk, Dibya, Plowright, Megan, Porter, Julie, Ravencroft, Phillip, Roddis, C, Rodger, J, Rowland-Jones, Sarah, Saunders, Peter, Sidebottom, J, Smith, Jacqui, Smith, Laurie, Steele, N, Stephens, G, Stimpson, R, Thamu, B, Thompson, A. A. Roger, Tinker, N, Turner, Kim, Turton, Helena, Wade, Phillip, Walker, S, Watson, James, Wilson, Imogen, Zawia, Amira, Allsop, Lynne, Bennett, Kaytie, Buckley, Phil, Flynn, Margaret, Gill, Mandy, Goodwin, Camelia, Greatorex, M, Gregory, Heidi, Heeley, Cheryl, Holloway, Leah, Holmes, Megan, Hutchinson, John, Kirk, Jill, Lovegrove, Wayne, Sewell, Terri Ann, Shelton, Sarah, Sissons, D, Slack, Katie, Smith, Susan, Sowter, D, Turner, Sarah, Whitworth, V, Wynter, Inez, Tomlinson, Johanne, Warburton, Louise, Painter, Sharon, Palmer, Sue, Redwood, Dawn, Tilley, Jo, Vickers, Carinna, Wainwright, Tania, Breen, G, Hotopf, M, Aul, Raminder, Forton, D, Ali, Mariam, Dunleavy, A, Mencias, Mark, Msimanga, N, Samakomva, T, Siddique, Sulman, Tavoukjian, Vera, Teixeira, J, Ahmed, Rubina, Francis, Richard, Connor, Lynda, Cook, Amanda, Davies, Gwyneth, Rees, Tabitha, Thaivalappil, Favas, Thomas, Caradog, McNarry, M, Williams, N, Lewis, Keir, Coulding, Martina, Jones, Heather, Kilroy, Susan, McCormick, Jacqueline, McIntosh, Jerome, Turner, Victoria, Vere, Joanne, Butt, Al-Tahoor, Savill, Heather, Kon, Samantha, Landers, G, Lota, Harpreet, Portukhay, Sofiya, Nasseri, Mariam, Daniels, Alison, Hormis, Anil, Ingham, Julie, Zeidan, Lisa, Chablani, Manish, Osborne, Lynn, Aslani, Shahab, Banerjee, Amita, Batterham, R, Baxter, Gabrielle, Bell, Robert, David, Anthony, Denneny, Emma, Hughes, Alun, Lilaonitkul, W, Mehta, P, Pakzad, Ashkan, Rangelov, Bojidar, Williams, B, Willoughby, James, Xu, Moucheng, Ahwireng, Nyarko, Bang, Dongchun, Basire, Donna, Brown, Jeremy, Chambers, Rachel, Checkley, A, Evans, R, Heightman, M, Hillman, T, Jacob, Joseph, Jastrub, Roman, Lipman, M, Logan, S, Lomas, D, Merida Morillas, Marta, Plant, Hannah, Porter, Joanna, Roy, K, Wall, E, Treibel, T, Ahmad Haider, N, Atkin, Catherine, Baggott, Rhiannon, Bates, Michelle, Botkai, A, Casey, Anna, Cooper, B, Dasgin, Joanne, Dawson, Camilla, Draxlbauer, Katharine, Gautam, N, Hazeldine, J, Hiwot, T, Holden, Sophie, Isaacs, Karen, Jackson, T, Kamwa, Vicky, Lewis, D, Lord, Janet, Madathil, S, McGee, C, Mcgee, K, Neal, Aoife, Newton-Cox, Alex, Nyaboko, Joseph, Parekh, Dhruv, Peterkin, Z, Qureshi, H, Ratcliffe, Liz, Sapey, Elizabeth, Short, J, Soulsby, Tracy, Stockley, J, Suleiman, Zehra, Thompson, Tamika, Ventura, Maximina, Walder, Sinead, Welch, Carly, Wilson, Daisy, Yasmin, S, Yip, Kay Por, Chaudhuri, N, Childs, Caroline, Djukanovic, R, Fletcher, S, Harvey, Matt, Jones, Mark, Marouzet, Elizabeth, Marshall, B, Samuel, Reena, Sass, T, Wallis, Tim, Wheeler, Helen, Steeds, R, Beckett, Paul, Dickens, Caroline, Nanda, Uttam, Aljaroof, M, Armstrong, Natalie, Arnold, H, Aung, Hnin, Bakali, Majda, Bakau, M, Baldry, E, Baldwin, Molly, Bourne, Charlotte, Bourne, Michelle, Brightling, Chris, Brunskill, Nigel, Cairns, P, Carr, Liesel, Charalambou, Amanda, Christie, C, Davies, Melanie, Daynes, Enya, Diver, Sarah, Dowling, Rachael, Edwards, Sarah, Edwardson, C, Elneima, Omer, Evans, H, Evans, Rachael, Finch, J, Glover, Sarah, Goodman, Nicola, Gooptu, Bibek, Greening, Neil, Hadley, Kate, Haldar, Pranab, Hargadon, Beverley, Harris, Victoria, Houchen-Wolloff, Linzy, Ibrahim, W, Ingram, L, Khunti, Kamlesh, Lea, A, Lee, D, McAuley, Hamish, McCann, Gerry, McCourt, P, Mcnally, Teresa, Mills, George, Monteiro, Will, Pareek, Manish, Parker, S, Prickett, Anne, Qureshi, I N, Rowland, A, Russell, Richard, Sereno, Marco, Shikotra, Aarti, Siddiqui, Salman, Singapuri, Ananga, Singh, Sally, Skeemer, J, Soares, M, Stringer, E, Thornton, T, Tobin, Martin, Ward, T J C, Woodhead, F, Yates, Tom, Yousuf, A J, Broome, Mattew, McArdle, Paul, Thickett, David, Upthegrove, Rachel, Wilkinson, Dan, Moss, Paul, Wraith, David, Evans, Jonathon, Bullmore, Ed, Heeney, Jonathon, Langenberg, Claudia, Schwaeble, William, Summers, Charlotte, Weir McCall, J, Adeloye, Davies, Newby, D E, Pius, Riinu, Rudan, Igor, Shankar-Hari, Manu, Sudlow, Catherine, Thorpe, Mat, Walmsley, Sarah, Zheng, Bang, Allan, Louise, Ballard, Clive, McGovern, Andrew, Dennis, J, Cavanagh, Jonathon, MacDonald, S, O'Donnell, Kate, Petrie, John, Sattar, Naveed, Spears, Mark, Guthrie, Elspeth, Henderson, Max, Allen, Richard, Bingham, Michelle, Brugha, Terry, Finney, Selina, Free, Rob, Jones, Don, Lawson, Claire, Lucy, Gardiner, Moss, Alistair, Mukaetova-Ladinska, Elizabeta, Novotny, Petr, Overton, Charlotte, Pearl, John, Plekhanova, Tatiana, Richardson, M, Samani, Nilesh, Sargant, Jack, Sharma, M, Steiner, Mike, Taylor, Chris, Terry, Sarah, Tong, C, Turner, E, Wormleighton, J, Zhao, Bang, Ntotsis, Kimon, Saunders, Ruth, Lozano-Rojas, Daniel, Goemans, Anne, Cuthbertson, D, Kemp, G, McArdle, Anne, Michael, Benedict, Reynolds, Will, Spencer, Lisa, Vinson, Ben, Ashworth, M, Abel, Kathryn, Chinoy, H, Deakin, Bill, Harvie, M, Miller, C A, Stanel, Stefan, Barran, Perdita, Trivedi, Drupad, McAllister-Williams, Hamish, Paddick, Stella-Maria, Rostron, Anthony, Taylor, John Paul, Baguley, David, Coleman, Chris, Cox, E, Fabbri, Laura, Francis, Susan, Hall, Ian, Hufton, E, Johnson, Simon, Khan, Fasih, Kitterick, Paaig, Morriss, Richard, Selby, Nick, Wright, Louise, Antoniades, Charalambos, Bates, A, Beggs, M, Bhui, Kamaldeep, Breeze, Katie, Channon, K M, Clark, David, Fu, X, Husain, Masud, Li, X, Lukaschuk, E, McCracken, Celeste, McGlynn, K, Menke, R, Motohashi, K, Nichols, T E, Ogbole, Godwin, Piechnik, S, Propescu, I, Propescu, J, Samat, A A, Sanders, Z B, Sigfrid, Louise, Webster, M, Kingham, Lucy, Klenerman, Paul, Lamlum, Hanan, Taquet, Maxime, Carson, G, Finnigan, L, Saunders, Laura, Wild, James, Calder, P C, Huneke, Nathan, Simons, Gemma, Baldwin, David, Bain, Steve, Daines, Luke, Bright, E, Crisp, P, Dharmagunawardena, Ruvini, Stern, M, Bailey, Elisabeth, Reddington, Anne, Wight, Andrew, Ashish, A, Cooper, Josh, Robinson, Emma, Broadley, Andrew, Barman, Laura, Brookes, Claire, Elliott, K, Griffiths, L, Guy, Zoe, Howard, Kate, Ionita, Diana, Redfearn, Heidi, Sarginson, Carol, Turnbull, Alison, Skorniewska, Zuzanna, De Deyn, Thomas, Hampshire, Adam, Trender, William R, Hellyer, Peter J, Chalmers, James D, Ho, Ling-Pei, Leavy, Olivia C, Richardson, Matthew, McAuley, Hamish J C, Singapuri, Amisha, Saunders, Ruth M, Harris, Victoria C, Greening, Neil J, Mansoori, Parisa, Harrison, Ewen M, Docherty, Annemarie B, Lone, Nazir I, Quint, Jennifer, Brightling, Christopher E, Wain, Louise V, Evans, Rachael A, Geddes, John R, and Harrison, Paul J

Published
2024
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18. A cluster randomised controlled trial, process and economic evaluation of quality improvement collaboratives aligned to a national audit to improve the care for people with diabetes (EQUIPD): study protocol

Author

Sykes, Michael, Copsey, Bethan, Finch, Tracy, Meads, David, Farrin, Amanda, McSharry, Jenny, Holman, Naomi, Young, Bob, Berry, Alex, Ellis, Kat, Moreau, Lauren, Willis, Thomas, Alderson, Sarah, Girling, Melissa, O’Halloran, Elaine, and Foy, Robbie

Published
2023
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19. Yohimbine Inhibits PDGF-Induced Vascular Smooth Muscle Cell Proliferation and Migration via FOXO3a Factor

Author

Leejin Lim, Hyeonhwa Kim, Jihye Jeong, Sung Hee Han, Young-Bob Yu, and Heesang Song

Subjects
yohimbine, proliferation, migration, vascular smooth muscle cells, FOXO3a, mTOR, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Yohimbine (YHB) has been reported to possess anti-inflammatory, anticancer, and cardiac function-enhancing properties. Additionally, it has been reported to inhibit the proliferation, migration, and neointimal formation of vascular smooth muscle cells (VSMCs) induced by platelet-derived growth factor (PDGF) stimulation by suppressing the phospholipase C-gamma 1 pathway. However, the transcriptional regulatory mechanism of YHB controlling the behavior of VSMCs is not fully understood. In this study, YHB downregulated the expression of cell cycle regulatory proteins, such as proliferating cell nuclear antigen (PCNA), cyclin D1, cyclin-dependent kinase 4 (CDK4), and cyclin E, by modulating the transcription factor FOXO3a in VSMCs induced by PDGF. Furthermore, YHB decreased p-38 and mTOR phosphorylation in a dose-dependent manner. Notably, YHB significantly reduced the phosphorylation at Y397 and Y925 sites of focal adhesion kinase (FAK), and this effect was greater at the Y925 site than Y397. In addition, the expression of paxillin, a FAK-associated protein known to bind to the Y925 site of FAK, was significantly reduced by YHB treatment in a dose-dependent manner. A pronounced reduction in the migration and proliferation of VSMCs was observed following co-treatment of YHB with mTOR or p38 inhibitors. In conclusion, this study shows that YHB inhibits the PDGF-induced proliferation and migration of VSMCs by regulating the transcription factor FOXO3a and the mTOR/p38/FAK signaling pathway. Therefore, YHB may be a potential therapeutic candidate for preventing and treating cardiovascular diseases such as atherosclerosis and vascular restenosis.

Published
2024
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20. Anticancer Activity of Astaxanthin-Incorporated Chitosan Nanoparticles

Author

Eun Ju Hwang, Young-IL Jeong, Kyong-Je Lee, Young-Bob Yu, Seung-Ho Ohk, and Sook-Young Lee

Subjects
astaxanthin, ROS scavenging, anticancer, chitosan, nanoparticle, Organic chemistry, QD241-441
Abstract

Astaxanthin (AST)-encapsulated nanoparticles were fabricated using glycol chitosan (Chito) through electrostatic interaction (abbreviated as ChitoAST) to solve the aqueous solubility of astaxanthin and improve its biological activity. AST was dissolved in organic solvents and then mixed with chitosan solution, followed by a dialysis procedure. All formulations of ChitoAST nanoparticles showed small diameters (less than 400 nm) with monomodal distributions. Analysis with Fourier transform infrared (FT-IR) spectroscopy confirmed the specific peaks of AST and Chito. Furthermore, ChitoAST nanoparticles were formed through electrostatic interactions between Chito and AST. In addition, ChitoAST nanoparticles showed superior antioxidant activity, as good as AST itself; the half maximal radical scavenging concentrations (RC50) of AST and ChitoAST nanoparticles were 11.8 and 29.3 µg/mL, respectively. In vitro, AST and ChitoAST nanoparticles at 10 and 20 µg/mL properly inhibited the production of intracellular reactive oxygen species (ROSs), nitric oxide (NO), and inducible nitric oxide synthase (iNOS). ChitoAST nanoparticles had no significant cytotoxicity against RAW264.7 cells or B16F10 melanoma cells, whereas AST and ChitoAST nanoparticles inhibited the growth of cancer cells. Furthermore, AST itself and ChitoAST nanoparticles (20 µg/mL) efficiently inhibited the migration of cancer cells in a wound healing assay. An in vivo study using mice and a pulmonary metastasis model showed that ChitoAST nanoparticles were efficiently delivered to a lung with B16F10 cell metastasis; i.e., fluorescence intensity in the lung was significantly higher than in other organs. We suggest that ChitoAST nanoparticles are promising candidates for antioxidative and anticancer therapies of B16F10 cells.

Published
2024
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22. Trends in hospitalization for cardio‐renal disease and mortality in people with type 1 diabetes in England, 2009–2019.

Author

Holman, Naomi, Young, Bob, Gregg, Edward W., Wareham, Nick, Sharp, Stephen, Khunti, Kamlesh, Sattar, Naveed, and Valabhji, Jonathan

Subjects
*BLACK youth, *TYPE 1 diabetes, *RESPIRATORY diseases, *DEMOGRAPHIC characteristics, *ETHNICITY, CARDIOVASCULAR disease related mortality
Abstract

Aim: To assess mortality and complication trends in people with type 1 diabetes during the 11 years before the SARS‐CoV2 pandemic (2009–2019). Materials and Methods: Sequential cohorts of people in England with type 1 diabetes aged ≥20 years from the National Diabetes Audit (2006/2007 to 2016/2017) were analysed. Discretized Poisson regression models, adjusted for age, sex, ethnicity, socioeconomic deprivation and duration of diabetes, were used to calculate mortality and hospitalization rates. Results: Demographic characteristics changed little; average diabetes duration increased. All‐cause mortality was unchanged. Cardiovascular and kidney disease mortality declined. Mortality from respiratory disease, diabetes and dementia increased in younger people (aged 20–74 years) as did mortality from liver disease and dementia in the elderly (aged ≥75 years). Younger Asian and Black people had lower all‐cause mortality than those of White ethnicity; elderly Mixed, Asian and Black people had lower all‐cause mortality. People from more deprived areas had higher all‐cause mortality. The deprivation gradient for mortality was steeper at younger ages. In younger people, rates of hospitalization increased for myocardial infarction, stroke, heart failure and kidney disease but only for kidney disease in the elderly. Rates of a composite measure of cardiovascular hospitalizations increased in younger people (rate ratio [RR] 1.07, 95% confidence interval [CI] 1.03–1.11) but declined in the elderly (RR 0.91, 95% CI 0.86–0.95). Conclusion: Between 2009 and 2019, hospitalizations for cardiovascular disease increased at younger ages (20–74 years) and hospitalizations for kidney disease increased at all ages, but mortality from cardiovascular and kidney disease declined. All‐cause mortality rates were unchanged. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Characteristics and outcomes of pregnant women with type 1 or type 2 diabetes: a 5-year national population-based cohort study

Author

Anglioni, Emily, Barron, Emma, Bell, Ruth, Berry, Alex, Cartright, Cher, Colling, Sophie, Curley, Matt, Duggan, Anna, Draper, Liz, Fargher, Laura, Flanagan, Melissa, Hawdon, Jane, Holt, Richard, Kurinczuk, Jenny, Maresh, Mike, Pinnock, Angela, Shonegeval, Lucy, Todd, Di, Tomkins, Nicola, Murphy, Helen R, Howgate, Carla, O'Keefe, Jackie, Myers, Jenny, Morgan, Margery, Coleman, Matthew A, Jolly, Matthew, Valabhji, Jonathan, Scott, Eleanor M, Knighton, Peter, Young, Bob, and Lewis-Barned, Nick

Published
2021
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26. Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK

Author

Taquet, Maxime, Skorniewska, Zuzanna, De Deyn, Thomas, Hampshire, Adam, Trender, William R, Hellyer, Peter J, Chalmers, James D, Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Raman, Betty, Leavy, Olivia C, Richardson, Matthew, Elneima, Omer, McAuley, Hamish J C, Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Saunders, Ruth M, Harris, Victoria C, Rogers, Natalie, Houchen-Wolloff, Linzy, Greening, Neil J, Mansoori, Parisa, Harrison, Ewen M, Docherty, Annemarie B, Lone, Nazir I, Quint, Jennifer, Brightling, Christopher E, Wain, Louise V, Evans, Rachael A, Geddes, John R, Harrison, Paul J, Lone, Nazir, Baillie, Kenneth, Pairo-Castineira, Erola, Avramidis, Nikos, Wain, Louise, Guillen-Guio, Beatriz, Leavy, Olivia, Jones, S, Armstrong, Lisa, Hairsine, Brigid, Henson, Helen, Kurasz, Claire, Shaw, Alison, Shenton, Liz, Dobson, Hannah, Dell, Amanda, Fairbairn, Sara, Hawkings, Nancy, Haworth, Jill, Hoare, Michaela, Lewis, Victoria, Lucey, Alice, Mallison, Georgia, Nassa, Heeah, Pennington, Chris, Price, Andrea, Price, Claire, Storrie, Andrew, Willis, Gemma, Young, Susan, Poinasamy, Krisnah, Walker, Samantha, Jarrold, Ian, Rawlik, Konrad, Sanderson, Amy, Chong-James, K, David, C, James, W Y, Pfeffer, Paul, Zongo, O, Martineau, Adrian, Manisty, C, Armour, Cherie, Brown, Vanessa, Busby, John, Connolly, Bronwen, Craig, Thelma, Drain, Stephen, Heaney, Liam, King, Bernie, Magee, Nick, Major, E, McAulay, Danny, McGarvey, Lorcan, McGinness, Jade, Peto, Tunde, Stone, Roisin, Bolger, Annette, Davies, Ffyon, Haggar, Ahmed, Lewis, Joanne, Lloyd, Arwel, Manley, R, McIvor, Emma, Menzies, Daniel, Roberts, K, Saxon, W, Southern, David, Subbe, Christian, Whitehead, Victoria, Bularga, Anda, Mills, Nicholas, Dawson, Joy, El-Taweel, Hosni, Robinson, Leanne, Brear, Lucy, Regan, Karen, Saralaya, Dinesh, Storton, Kim, Amoils, Shannon, Bermperi, Areti, Cruz, Isabel, Dempsey, K, Elmer, Anne, Fuld, Jonathon, Jones, H, Jose, Sherly, Marciniak, Stefan, Parkes, M, Ribeiro, Carla, Taylor, Jessica, Toshner, Mark, Watson, L, Worsley, J, Broad, Lauren, Evans, Teriann, Haynes, Matthew, Jones, L, Knibbs, Lucy, McQueen, Alison, Oliver, Catherine, Paradowski, Kerry, Sabit, Ramsey, Williams, Jenny, Jones, Ian, Milligan, Lea, Harris, Edward, Sampson, Claire, Davies, Ellie, Evenden, Cerys, Hancock, Alyson, Hancock, Kia, Lynch, Ceri, Rees, Meryl, Roche, Lisa, Stroud, Natalie, Thomas-Woods, T, Heller, Simon, Chalder, Trudie, Shah, Kamini, Robertson, Elizabeth, Young, Bob, Babores, Marta, Holland, Maureen, Keenan, Natalie, Shashaa, Sharlene, Wassall, Helen, Austin, Liam, Beranova, Eva, Cosier, Tracey, Deery, Joanne, Hazelton, Tracy, Price, Carly, Ramos, Hazel, Solly, Reanne, Turney, Sharon, Weston, Heather, Coughlan, Eamon, Ralser, Markus, Pearce, Lorraine, Pugmire, S, Stoker, Wendy, Wilson, Ann, McCormick, W, Fraile, Eva, Ugoji, Jacinta, Aguilar Jimenez, Laura, Arbane, Gill, Betts, Sarah, Bisnauthsing, Karen, Dewar, A, Hart, Nicholas, Kaltsakas, G, Kerslake, Helen, Magtoto, Murphy, Marino, Philip, Martinez, L M, Ostermann, Marlies, Rossdale, Jennifer, Solano, Teresa, Alvarez Corral, Maria, Arias, Ava Maria, Bevan, Emily, Griffin, Denise, Martin, Jane, Owen, J, Payne, Sheila, Prabhu, A, Reed, Annabel, Storrar, Will, Williams, Nick, Wrey Brown, Caroline, Burdett, Tracy, Featherstone, James, Lawson, Cathy, Layton, Alison, Mills, Clare, Stephenson, Lorraine, Ellis, Yvette, Atkin, Paul, Brindle, K, Crooks, Michael, Drury, Katie, Easom, Nicholas, Flockton, Rachel, Holdsworth, L, Richards, A, Sykes, D L, Thackray-Nocera, Susannah, Wright, C, Coetzee, S, Davies, Kim, Hughes, Rachel Ann, Loosley, Ronda, McGuinness, Heather, Mohamed, Abdelrahman, O'Brien, Linda, Omar, Zohra, Perkins, Emma, Phipps, Janet, Ross, Gavin, Taylor, Abigail, Tench, Helen, Wolf-Roberts, Rebecca, Burden, L, Calvelo, Ellen, Card, Bethany, Carr, Caitlin, Chilvers, Edwin, Copeland, Donna, Cullinan, P, Daly, Patrick, Evison, Lynsey, Fayzan, Tamanah, Gordon, Hussain, Haq, Sulaimaan, Jenkins, Gisli, King, Clara, Kon, Onn Min, March, Katherine, Mariveles, Myril, McLeavey, Laura, Mohamed, Noura, Moriera, Silvia, Munawar, Unber, Nunag, Jose Lloyd, Nwanguma, Uchechi, Orriss-Dib, Lorna, Ross, Alexandra, Roy, Maura, Russell, Emily, Samuel, Katherine, Schronce, J, Simpson, Neil, Tarusan, Lawrence, Thomas, David, Wood, Chloe, Yasmin, Najira, Altmann, Danny, Howard, Luke, Johnston, Desmond, Lingford-Hughes, Anne, Man, William, Mitchell, Jane, Molyneaux, Philip, Nicolaou, Christos, O'Regan, D P, Price, L, Quint, Jenni, Smith, David, Thwaites, Ryan, Valabhji, Jonathon, Walsh, Simon, Efstathiou, Claudia, Liew, Felicity, Frankel, Anew, Lightstone, Liz, McAdoo, Steve, Wilkins, Martin, Willicombe, Michelle, Touyz, R, Guerdette, Anne-Marie, Hewitt, Melanie, Reddy, R, Warwick, Katie, White, Sonia, McMahon, Aisling, Adeyemi, Oluwaseun, Adrego, Rita, Assefa-Kebede, Hosanna, Breeze, Jonathon, Byrne, S, Dulawan, Pearl, Hoare, Amy, Jolley, Caroline, Knighton, Abigail, Patale, Sheetal, Peralta, Ida, Powell, Natassia, Ramos, Albert, Shevket, K, Speranza, Fabio, Te, Amelie, Malim, M, Bramham, Kate, Brown, M, Ismail, Khalida, Nicholson, Tim, Pariante, Carmen, Sharpe, Claire, Wessely, Simon, Whitney, J, Shah, Ajay, Chiribiri, A, O'Brien, C, Hayday, A, Ashworth, Andrew, Beirne, Paul, Clarke, Jude, Coupland, C, Dalton, Matthhew, Favager, Clair, Glossop, Jodie, Greenwood, John, Hall, Lucy, Hardy, Tim, Humphries, Amy, Murira, Jennifer, Peckham, Dan, Plein, S, Rangeley, Jade, Saalmink, Gwen, Tan, Ai Lyn, Wade, Elaine, Whittam, Beverley, Window, Nicola, Woods, Janet, Coakley, G, Turtle, Lance, Allerton, Lisa, Allt, Ann Marie, Beadsworth, M, Berridge, Anthony, Brown, Jo, Cooper, Shirley, Cross, Andy, Defres, Sylviane, Dobson, S L, Earley, Joanne, French, N, Greenhalf, William, Hainey, Kera, Hardwick, Hayley, Hawkes, Jenny, Highett, Victoria, Kaprowska, Sabina, Key, Angela, Lavelle-Langham, Lara, Lewis-Burke, N, Madzamba, Gladys, Malein, Flora, Marsh, Sophie, Mears, Chloe, Melling, Lucy, Noonan, Matthew, Poll, L, Pratt, James, Richardson, Emma, Rowe, Anna, Semple, Calum, Shaw, Victoria, Tripp, K A, Wajero, Lilian, Williams-Howard, S A, Wootton, Dan, Wyles, J, Diwanji, Shalin, Gurram, Sambasivarao, Papineni, Padmasayee, Quaid, Sheena, Tiongson, Gerlynn, Watson, Ekaterina, Briggs, Andrew, Marks, Michael, Hastie, Claire, Rogers, Natalie, Smith, Nikki, Stensel, David, Bishop, Lettie, McIvor, Katherine, Rivera-Ortega, Pilar, Al-Sheklly, Bashar, Avram, Cristina, Blaikely, John, Buch, M, Choudhury, N, Faluyi, David, Felton, T, Gorsuch, T, Hanley, Neil, Horsley, Alex, Hussell, Tracy, Kausar, Zunaira, Odell, Natasha, Osbourne, Rebecca, Piper Hanley, Karen, Radhakrishnan, K, Stockdale, Sue, Kabir, Thomas, Scott, Janet, Stewart, Iain, Openshaw, Peter, Burn, David, Ayoub, A, Brown, J, Burns, G, Davies, Gareth, De Soyza, Anthony, Echevarria, Carlos, Fisher, Helen, Francis, C, Greenhalgh, Alan, Hogarth, Philip, Hughes, Joan, Jiwa, Kasim, Jones, G, MacGowan, G, Price, D, Sayer, Avan, Simpson, John, Tedd, H, Thomas, S, West, Sophie, Witham, M, Wright, S, Young, A, McMahon, Michael, Neill, Paula, Anderson, David, Basu, Neil, Bayes, Hannah, Brown, Ammani, Dougherty, Andrew, Fallon, K, Gilmour, L, Grieve, D, Mangion, K, Morrow, A, Sykes, R, Berry, Colin, McInnes, I B, Scott, Kathryn, Barrett, Fiona, Donaldson, A, Sage, Beth, Bell, Murdina, Brown, Angela, Brown, M, Hamil, R, Leitch, Karen, Macliver, L, Patel, Manish, Quigley, Jackie, Smith, Andrew, Welsh, B, Choudhury, Gaunab, Clohisey, S, Deans, Andrew, Docherty, Annemarie, Furniss, J, Harrison, Ewen, Kelly, S, Sheikh, Aziz, Chalmers, James, Connell, David, Deas, C, Elliott, Anne, George, J, Mohammed, S, Rowland, J, Solstice, AR, Sutherland, Debbie, Tee, Caroline, Bunker, Jenny, Gill, Rhyan, Nathu, Rashmita, Holmes, Katie, Adamali, H, Arnold, David, Barratt, Shaney, Dipper, A, Dunn, Sarah, Maskell, Nick, Morley, Anna, Morrison, Leigh, Stadon, Louise, Waterson, Samuel, Welch, H, Jayaraman, Bhagy, Light, Tessa, Vogiatzis, Ioannis, Almeida, Paula, Bolton, Charlotte, Hosseini, Akram, Matthews, Laura, Needham, Robert, Shaw, Karen, Thomas, Andrew, Bonnington, J, Chrystal, Melanie, Dupont, Catherine, Greenhaff, Paul, Gupta, Ayushman, Jang, W, Linford, S, Nikolaidis, Athanasios, Prosper, Sabrina, Burns, A, Kanellakis, N, Ferreira, V, Nikolaidou, C, Xie, C, Ainsworth, Mark, Alamoudi, Asma, Bloss, Angela, Carter, Penny, Cassar, M, Chen, Jin, Conneh, Florence, Dong, T, Evans, Ranuromanana, Fraser, Emily, Geddes, John, Gleeson, F, Harrison, Paul, Havinden-Williams, May, Ho, Ling Pei, Jezzard, P, Koychev, Ivan, Kurupati, Prathiba, McShane, H, Megson, Clare, Neubauer, Stefan, Nicoll, Debby, Ogg, G, Pacpaco, Edmund, Pavlides, M, Peng, Yanchun, Petousi, Nayia, Pimm, John, Rahman, Najib, Raman, Betty, Rowland, M J, Saunders, Kathryn, Sharpe, Michael, Talbot, Nick, Tunnicliffe, E M, Korszun, Ania, Kerr, Steven, Barker, R E, Cristiano, Daniele, Dormand, N, George, P, Gummadi, Mahitha, Kon, S, Liyanage, Kamal, Nolan, C M, Patel, B, Patel, Suhani, Polgar, Oliver, Price, L, Shah, P, Singh, Suver, Walsh, J A, Gibbons, Michael, Ahmad, Shanaz, Brill, Simon, Hurst, John, Jarvis, Hannah, Lim, Lai, Mandal, S, Matila, Darwin, Olaosebikan, Olaoluwa, Singh, Claire, Laing, C, Baxendale, Helen, Garner, Lucie, Johnson, C, Mackie, J, Michael, Alice, Newman, J, Pack, Jamie, Paques, K, Parfrey, H, Parmar, J, Reddy, A, Halling-Brown, Mark, Dark, P, Diar-Bakerly, Nawar, Evans, D, Hardy, E, Harvey, Alice, Holgate, D, Knight, Sean, Mairs, N, Majeed, N, McMorrow, L, Oxton, J, Pendlebury, Jessica, Summersgill, C, Ugwuoke, R, Whittaker, S, Matimba-Mupaya, Wadzanai, Strong-Sheldrake, Sophia, Chowienczyk, Phillip, Bagshaw, J, Begum, M, Birchall, K, Butcher, Robyn, Carborn, H, Chan, Flora, Chapman, Kerry, Cheng, Yutung, Chetham, Luke, Clark, Cameron, Coburn, Zach, Cole, Joby, Dixon, Myles, Fairman, Alexandra, Finnigan, J, Foot, H, Foote, David, Ford, Amber, Gregory, Rebecca, Harrington, Kate, Haslam, L, Hesselden, L, Hockridge, J, Holbourn, Ailsa, Holroyd-Hind, B, Holt, L, Howell, Alice, Hurditch, E, Ilyas, F, Jarman, Claire, Lawrie, Allan, Lee, Ju Hee, Lee, Elvina, Lenagh, Rebecca, Lye, Alison, Macharia, Irene, Marshall, M, Mbuyisa, Angeline, McNeill, J, Megson, Sharon, Meiring, J, Milner, L, Misra, S, Newell, Helen, Newman, Tom, Norman, C, Nwafor, Lorenza, Pattenadk, Dibya, Plowright, Megan, Porter, Julie, Ravencroft, Phillip, Roddis, C, Rodger, J, Rowland-Jones, Sarah, Saunders, Peter, Sidebottom, J, Smith, Jacqui, Smith, Laurie, Steele, N, Stephens, G, Stimpson, R, Thamu, B, Thompson, A. A. Roger, Tinker, N, Turner, Kim, Turton, Helena, Wade, Phillip, Walker, S, Watson, James, Wilson, Imogen, Zawia, Amira, Allsop, Lynne, Bennett, Kaytie, Buckley, Phil, Flynn, Margaret, Gill, Mandy, Goodwin, Camelia, Greatorex, M, Gregory, Heidi, Heeley, Cheryl, Holloway, Leah, Holmes, Megan, Hutchinson, John, Kirk, Jill, Lovegrove, Wayne, Sewell, Terri Ann, Shelton, Sarah, Sissons, D, Slack, Katie, Smith, Susan, Sowter, D, Turner, Sarah, Whitworth, V, Wynter, Inez, Tomlinson, Johanne, Warburton, Louise, Painter, Sharon, Palmer, Sue, Redwood, Dawn, Tilley, Jo, Vickers, Carinna, Wainwright, Tania, Breen, G, Hotopf, M, Aul, Raminder, Forton, D, Ali, Mariam, Dunleavy, A, Mencias, Mark, Msimanga, N, Samakomva, T, Siddique, Sulman, Tavoukjian, Vera, Teixeira, J, Ahmed, Rubina, Francis, Richard, Connor, Lynda, Cook, Amanda, Davies, Gwyneth, Rees, Tabitha, Thaivalappil, Favas, Thomas, Caradog, McNarry, M, Williams, N, Lewis, Keir, Coulding, Martina, Jones, Heather, Kilroy, Susan, McCormick, Jacqueline, McIntosh, Jerome, Turner, Victoria, Vere, Joanne, Butt, Al-Tahoor, Savill, Heather, Kon, Samantha, Landers, G, Lota, Harpreet, Portukhay, Sofiya, Nasseri, Mariam, Daniels, Alison, Hormis, Anil, Ingham, Julie, Zeidan, Lisa, Chablani, Manish, Osborne, Lynn, Aslani, Shahab, Banerjee, Amita, Batterham, R, Baxter, Gabrielle, Bell, Robert, David, Anthony, Denneny, Emma, Hughes, Alun, Lilaonitkul, W, Mehta, P, Pakzad, Ashkan, Rangelov, Bojidar, Williams, B, Willoughby, James, Xu, Moucheng, Ahwireng, Nyarko, Bang, Dongchun, Basire, Donna, Brown, Jeremy, Chambers, Rachel, Checkley, A, Evans, R, Heightman, M, Hillman, T, Jacob, Joseph, Jastrub, Roman, Lipman, M, Logan, S, Lomas, D, Merida Morillas, Marta, Plant, Hannah, Porter, Joanna, Roy, K, Wall, E, Treibel, T, Ahmad Haider, N, Atkin, Catherine, Baggott, Rhiannon, Bates, Michelle, Botkai, A, Casey, Anna, Cooper, B, Dasgin, Joanne, Dawson, Camilla, Draxlbauer, Katharine, Gautam, N, Hazeldine, J, Hiwot, T, Holden, Sophie, Isaacs, Karen, Jackson, T, Kamwa, Vicky, Lewis, D, Lord, Janet, Madathil, S, McGee, C, Mcgee, K, Neal, Aoife, Newton-Cox, Alex, Nyaboko, Joseph, Parekh, Dhruv, Peterkin, Z, Qureshi, H, Ratcliffe, Liz, Sapey, Elizabeth, Short, J, Soulsby, Tracy, Stockley, J, Suleiman, Zehra, Thompson, Tamika, Ventura, Maximina, Walder, Sinead, Welch, Carly, Wilson, Daisy, Yasmin, S, Yip, Kay Por, Chaudhuri, N, Childs, Caroline, Djukanovic, R, Fletcher, S, Harvey, Matt, Jones, Mark, Marouzet, Elizabeth, Marshall, B, Samuel, Reena, Sass, T, Wallis, Tim, Wheeler, Helen, Steeds, R, Beckett, Paul, Dickens, Caroline, Nanda, Uttam, Aljaroof, M, Armstrong, Natalie, Arnold, H, Aung, Hnin, Bakali, Majda, Bakau, M, Baldry, E, Baldwin, Molly, Bourne, Charlotte, Bourne, Michelle, Brightling, Chris, Brunskill, Nigel, Cairns, P, Carr, Liesel, Charalambou, Amanda, Christie, C, Davies, Melanie, Daynes, Enya, Diver, Sarah, Dowling, Rachael, Edwards, Sarah, Edwardson, C, Elneima, Omer, Evans, H, Evans, Rachael, Finch, J, Glover, Sarah, Goodman, Nicola, Gooptu, Bibek, Greening, Neil, Hadley, Kate, Haldar, Pranab, Hargadon, Beverley, Harris, Victoria, Houchen-Wolloff, Linzy, Ibrahim, W, Ingram, L, Khunti, Kamlesh, Lea, A, Lee, D, McAuley, Hamish, McCann, Gerry, McCourt, P, Mcnally, Teresa, Mills, George, Monteiro, Will, Pareek, Manish, Parker, S, Prickett, Anne, Qureshi, I N, Rowland, A, Russell, Richard, Sereno, Marco, Shikotra, Aarti, Siddiqui, Salman, Singapuri, Ananga, Singh, Sally, Skeemer, J, Soares, M, Stringer, E, Thornton, T, Tobin, Martin, Ward, T J C, Woodhead, F, Yates, Tom, Yousuf, A J, Broome, Mattew, McArdle, Paul, Thickett, David, Upthegrove, Rachel, Wilkinson, Dan, Moss, Paul, Wraith, David, Evans, Jonathon, Bullmore, Ed, Heeney, Jonathon, Langenberg, Claudia, Schwaeble, William, Summers, Charlotte, Weir McCall, J, Adeloye, Davies, Newby, D E, Pius, Riinu, Rudan, Igor, Shankar-Hari, Manu, Sudlow, Catherine, Thorpe, Mat, Walmsley, Sarah, Zheng, Bang, Allan, Louise, Ballard, Clive, McGovern, Andrew, Dennis, J, Cavanagh, Jonathon, MacDonald, S, O'Donnell, Kate, Petrie, John, Sattar, Naveed, Spears, Mark, Guthrie, Elspeth, Henderson, Max, Allen, Richard, Bingham, Michelle, Brugha, Terry, Finney, Selina, Free, Rob, Jones, Don, Lawson, Claire, Lucy, Gardiner, Moss, Alistair, Mukaetova-Ladinska, Elizabeta, Novotny, Petr, Overton, Charlotte, Pearl, John, Plekhanova, Tatiana, Richardson, M, Samani, Nilesh, Sargant, Jack, Sharma, M, Steiner, Mike, Taylor, Chris, Terry, Sarah, Tong, C, Turner, E, Wormleighton, J, Zhao, Bang, Ntotsis, Kimon, Saunders, Ruth, Lozano-Rojas, Daniel, Goemans, Anne, Cuthbertson, D, Kemp, G, McArdle, Anne, Michael, Benedict, Reynolds, Will, Spencer, Lisa, Vinson, Ben, Ashworth, M, Abel, Kathryn, Chinoy, H, Deakin, Bill, Harvie, M, Miller, C A, Stanel, Stefan, Barran, Perdita, Trivedi, Drupad, McAllister-Williams, Hamish, Paddick, Stella-Maria, Rostron, Anthony, Taylor, John Paul, Baguley, David, Coleman, Chris, Cox, E, Fabbri, Laura, Francis, Susan, Hall, Ian, Hufton, E, Johnson, Simon, Khan, Fasih, Kitterick, Paaig, Morriss, Richard, Selby, Nick, Wright, Louise, Antoniades, Charalambos, Bates, A, Beggs, M, Bhui, Kamaldeep, Breeze, Katie, Channon, K M, Clark, David, Fu, X, Husain, Masud, Li, X, Lukaschuk, E, McCracken, Celeste, McGlynn, K, Menke, R, Motohashi, K, Nichols, T E, Ogbole, Godwin, Piechnik, S, Propescu, I, Propescu, J, Samat, A A, Sanders, Z B, Sigfrid, Louise, Webster, M, Kingham, Lucy, Klenerman, Paul, Lamlum, Hanan, Taquet, Maxime, Carson, G, Finnigan, L, Saunders, Laura, Wild, James, Calder, P C, Huneke, Nathan, Simons, Gemma, Baldwin, David, Bain, Steve, Daines, Luke, Bright, E, Crisp, P, Dharmagunawardena, Ruvini, Stern, M, Bailey, Elisabeth, Reddington, Anne, Wight, Andrew, Ashish, A, Cooper, Josh, Robinson, Emma, Broadley, Andrew, Barman, Laura, Brookes, Claire, Elliott, K, Griffiths, L, Guy, Zoe, Howard, Kate, Ionita, Diana, Redfearn, Heidi, Sarginson, Carol, and Turnbull, Alison

Abstract

COVID-19 is known to be associated with increased risks of cognitive and psychiatric outcomes after the acute phase of disease. We aimed to assess whether these symptoms can emerge or persist more than 1 year after hospitalisation for COVID-19, to identify which early aspects of COVID-19 illness predict longer-term symptoms, and to establish how these symptoms relate to occupational functioning.

Published
2024
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33. School Grounds: A Guide to Good Practice. Building Bulletin 85.

Author

Department for Education and Employment, London (England). Architects and Building Branch., Funnell, Keith, Alford, Valerie, Denegri, Don, Johns, Sally, Young, Bob, Lucas, Bill, Titman, Wendy, and Wood, Joan

Abstract

Limited financial resources and increasing pressures of competing claims on school outdoor grounds have created the need for greater quality enhancement of these areas to ensure they are used efficiently. This document addresses the issues and principles affecting school grounds, provides an analysis of the benefits of using and developing these areas, and outlines the processes necessary for successful school ground management as advocated by Learning through Landscapes. Chapters examine why ground surveying is important; how the National Curriculum provides a framework for the need to teach in the outdoor classroom; and why schools should develop a clear justification for their management of breaks and lunch times, as well as the special nature of this experience and its connection with student behavior. Additionally explored are recent research on the hidden curriculum and how school ground design influences behavior, different options and their contractual arrangements for school ground maintenance, and resources for planning grounds changes. It discusses the importance of the process of developing school grounds and of student involvement. Concluding sections offer reference material that includes information for school site and zone development, sports facilities, maintenance scheduling, key staff responsibilities, and a list of informational sources. Contains an index. (GR)

Published
1997

34. Stimuli-Responsive Drug Delivery of Doxorubicin Using Magnetic Nanoparticle Conjugated Poly(ethylene glycol)-g-Chitosan Copolymer

Author

Hyun-Min Yoon, Min-Su Kang, Go-Eun Choi, Young-Joon Kim, Chang-Hyu Bae, Young-Bob Yu, and Young-IL Jeong

Subjects
iron-oxide nanoparticle, magnetic nanoparticle, redox-responsiveness, chitosan, stimuli-responsiveness, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Stimuli-responsive nanoparticles are regarded as an ideal candidate for anticancer drug targeting. We synthesized glutathione (GSH) and magnetic-sensitive nanocomposites for a dual-targeting strategy. To achieve this goal, methoxy poly (ethylene glycol) (MePEG) was grafted to water-soluble chitosan (abbreviated as ChitoPEG). Then doxorubicin (DOX) was conjugated to the backbone of chitosan via disulfide linkage. Iron oxide (IO) magnetic nanoparticles were also conjugated to the backbone of chitosan to provide magnetic sensitivity. In morphological observation, images from a transmission electron microscope (TEM) showed that IO nanoparticles were embedded in the ChitoPEG/DOX/IO nanocomposites. In a drug release study, GSH addition accelerated DOX release rate from nanocomposites, indicating that nanocomposites have redox-responsiveness. Furthermore, external magnetic stimulus concentrated nanocomposites in the magnetic field and then provided efficient internalization of nanocomposites into cancer cells in cell culture experiments. In an animal study with CT26 cell-bearing mice, nanocomposites showed superior magnetic sensitivity and then preferentially targeted tumor tissues in the field of external magnetic stimulus. Nanocomposites composed of ChitoPEG/DOX/IO nanoparticle conjugates have excellent anticancer drug targeting properties.

Published
2021
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35. Reactive Oxygen Species-Sensitive Nanophotosensitizers of Methoxy Poly(ethylene glycol)-Chlorin e6/Phenyl Boronic Acid Pinacol Ester Conjugates Having Diselenide Linkages for Photodynamic Therapy of Cervical Cancer Cells

Author

Ju-Il Yang, Hye-Lim Lee, Seon-Hee Choi, Jungsoo Kim, Young-Bob Yu, Young-IL Jeong, and Dae-Hwan Kang

Subjects
nanophotosensitizer, ROS-sensitive, photodynamic therapy, cervical cancer, chlorin e6, Technology, Electrical engineering. Electronics. Nuclear engineering, TK1-9971, Engineering (General). Civil engineering (General), TA1-2040, Microscopy, QH201-278.5, Descriptive and experimental mechanics, QC120-168.85
Abstract

The aim of this study is to fabricate nanophotosensitizers composed of methoxy poly(ethylene glycol) (mPEG), chlorin e6 (Ce6), and phenylboronic acid pinacol ester (PBAP) with diselenide linkages for reactive oxygen species (ROS)-sensitive photodynamic therapy (PDT) of cervical cancer cells. To fabricate nanophotosensitizers, Ce6 was conjugated with mPEG via selenocystamine linkage and then remaining carboxylic acid groups of Ce6 was attached to PBAP (mPEGseseCe6PBAP conjugates). Nanophotosensitizers of mPEGseseCe6PBAP conjugates were prepared by dialysis method. In transmission electron microscope (TEM) observation, nanophotosensitizers of mPEGseseCe6PBAP conjugates have spherical shapes and their diameters were less than 150 nm. The average diameter of mPEGseseCe6PBAP nanophotosensitizers was 92.7 ± 9.6 nm in particle size analysis. When H2O2 was added to the nanophotosensitizer solution, nanophotosensitizers were sensitively disintegrated according to the H2O2 concentration and then changed from monomodal distribution to multimodal distribution in particle size distribution. Furthermore, Ce6 release from nanophotosensitizers also increased according to the H2O2 concentration. When H2O2 was added to cell culture of HeLa human cervical cancer cells, intracellular Ce6 uptake of nanophotosensitizers were gradually increased according to the H2O2 concentration, indicating that nanophotosensitizers showed ROS-sensitive delivery of Ce6 against cancer cells.As well as free Ce6, nanophotosensitizers in the absence of light irradiation have low intrinsic cytotoxicity against RAW264.7 cells and HeLa cells. However, nanophotosensitizers induced cell death dose-dependently under light irradiation. Especially, nanophotosensitizers showed significantly higher ROS generation and phototoxicity against HeLa cells in vitro. When nanophotosensitizers were intravenously administered to animal tumor xenograft model of HeLa cells, tumor tissues revealed stronger fluorescence intensity than other tissues by light irradiation while absence of light irradiation induced relatively lower fluorescence intensity in tumor tissues, indicating that nanophotosensitizers have sensitivity against oxidative stress in tumor tissues. We suggest that nanophotosensitizers of mPEGseseCe6PBAP conjugates are promising vehicle for PDT of cervical cancer cells.

Published
2021
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38. HOLSTER FOR A CZ 85

Author

Young, Bob

Subjects
Business, Sports, sporting goods and toys industry
Abstract

James Pollock of Missouri wrote in May issue's 'Reader Blowback' that he could not find a left-hand inside-the-waistband (IWB) holster for his CZ 85 Combat pistol. Jim, if you're reading [...]

Published
2022

43. Physical and Mental Health Effects of Long Covid in People with Diabetes 12 Months after Hospitalisation in the UK: A Prospective Cohort Study

Author

Gharibzadeh, Safoora, primary, Routen, Ash, additional, Razieh, Cameron, additional, Zaccardi, Francesco, additional, Lawson, Claire, additional, Gillies, Clare L., additional, Heller, Simon, additional, Davies, Melanie J., additional, Bain, Stephen C., additional, Kar, Partha, additional, Lone, Nazir, additional, Poinasamy, Krisnah, additional, Peto, Tunde, additional, Shah, Kamini, additional, Robertson, Elizabeth, additional, Young, Bob, additional, Johnston, Desmond G., additional, Quint, Jennifer, additional, Valabhji, Jonathan, additional, Ismail, Khalida, additional, Marks, Michael, additional, Horsley, Alex, additional, Docherty, Annemarie, additional, Harrison, Ewen M., additional, Chalmers, James D., additional, Ho, Ling-Pei, additional, Raman, Betty, additional, Brightling, Christopher, additional, Elneima, Omer, additional, Evans, Rachael A., additional, Greening, Neil J., additional, Harris, Victoria C., additional, Houchen-Wolloff, Linzy, additional, Sereno, Marco, additional, Shikotra, Aarti, additional, Singapuri, Amisha, additional, Wain, Louise, additional, Langenberg, Claudia, additional, McGovern, Andrew, additional, Dennis, John, additional, Petrie, John, additional, Sattar, Naveed, additional, Leavy, Olivia, additional, Matthew, Richardson, additional, Saunders, Rob, additional, McArdle, Anne, additional, McAuley, Hamish J. C., additional, Yates, Tom, additional, and Khunti, Kamlesh, additional

Published
2023
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46. Improving risk prediction model quality in the critically ill: data linkage study

Author

Ferrando-Vivas, Paloma, primary, Shankar-Hari, Manu, additional, Thomas, Karen, additional, Doidge, James C, additional, Caskey, Fergus J, additional, Forni, Lui, additional, Harris, Steve, additional, Ostermann, Marlies, additional, Gornik, Ivan, additional, Holman, Naomi, additional, Lone, Nazir, additional, Young, Bob, additional, Jenkins, David, additional, Webb, Stephen, additional, Nolan, Jerry P, additional, Soar, Jasmeet, additional, Rowan, Kathryn M, additional, and Harrison, David A, additional

Published
2022
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47. Effectiveness of digital and remote provision of the Healthier You: NHS Diabetes Prevention Programme during the COVID-19 pandemic

Author

Barron, Emma, Bradley, Dominque, Safazadeh, Soraya, McGough, Ben, Bakhai, Chirag, Young, Bob, Khunti, Kamlesh, Murray, Elizabeth, Wareham, Nick, Jebb, Susan, Valabhji, Jonathan, Barron, Emma [0000-0001-6257-9044], Khunti, Kamlesh [0000-0003-2343-7099], and Apollo - University of Cambridge Repository

Subjects
Prevention, Diabetes, Clinical Trials and Supportive Activities, COVID-19, 3 Good Health and Well Being, Prevention of type 2 diabetes, State Medicine, Diabetes Mellitus, Type 2, Clinical Research, Weight Loss, Humans, Obesity, Pandemics, Metabolic and endocrine, Nutrition
Abstract

AIMS: To assess weight change in the Healthier You: NHS Diabetes Prevention Programme (NHS DPP) delivered via video conferencing (remote) sessions or delivered via specific digital interventions through apps or websites, during the COVID-19 pandemic compared to group-based face-to-face interventions, pre-pandemic. METHODS: Prospectively collected national service-level data relating to individuals with non-diabetic hyperglycaemia (HbA1c 42-47 mmol/mol (6.0%-6.4%) or fasting plasma glucose 5.5-6.9 mmol/L) referred to the NHS DPP from June 2016 to March 2022. RESULTS: Between March 2020 and March 2022, 335,961 people were referred to the programme and were offered a choice of remote or digital intervention. This was preceded by 556,793 people referred to the face-to-face programme between June 2016 and February 2022. Uptakes to intervention sessions were 47% for those offered a choice and 39% for face-to-face. Remote and digital participants were significantly younger (60 and 56 vs. 65 years) and heavier (86.1 kg and 91.0 kg vs. 84.1 kg) compared to face-to-face. Weight change was assessed for 42,407 remote, 7699 digital and 97,205 face-to-face participants with sufficient time to have finished the programme and no missing data. Mean weight losses for participants attending at least one intervention session were: 2.40 (2.36-2.44) kg, 2.59 (2.49-2.68) kg and 2.01 (1.98-2.04) kg for remote, digital and face-to-face participants respectively. Corresponding mean weight losses for those who completed the programme were: 3.24 (3.19-3.30) kg, 4.76 (4.60-4.92) kg and 3.04 (3.00-3.07) kg. There were no significant differences in weight change between interventions by ethnicity and deprivation. CONCLUSIONS: Weight losses achieved through remote and digital interventions were greater than those previously achieved through face-to-face interventions, without evidence of exacerbation of health inequalities.

Published
2023
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49. Reactive Oxygen Species-Sensitive Nanophotosensitizers of Methoxy Poly(ethylene glycol)-Chlorin e6/Phenyl Boronic Acid Pinacol Ester Conjugates Having Diselenide Linkages for Photodynamic Therapy of Cervical Cancer Cells

Author

Ju-Il Yang, Hye-Lim Lee, Seon-Hee Choi, Jungsoo Kim, Young-Bob Yu, Young-IL Jeong, and Dae-Hwan Kang

Subjects
nanophotosensitizer, ROS-sensitive, photodynamic therapy, cervical cancer, chlorin e6, Technology, Microscopy, QC120-168.85, QH201-278.5, Engineering (General). Civil engineering (General), Article, TK1-9971, Descriptive and experimental mechanics, General Materials Science, Electrical engineering. Electronics. Nuclear engineering, TA1-2040
Abstract

The aim of this study is to fabricate nanophotosensitizers composed of methoxy poly(ethylene glycol) (mPEG), chlorin e6 (Ce6), and phenylboronic acid pinacol ester (PBAP) with diselenide linkages for reactive oxygen species (ROS)-sensitive photodynamic therapy (PDT) of cervical cancer cells. To fabricate nanophotosensitizers, Ce6 was conjugated with mPEG via selenocystamine linkage and then remaining carboxylic acid groups of Ce6 was attached to PBAP (mPEGseseCe6PBAP conjugates). Nanophotosensitizers of mPEGseseCe6PBAP conjugates were prepared by dialysis method. In transmission electron microscope (TEM) observation, nanophotosensitizers of mPEGseseCe6PBAP conjugates have spherical shapes and their diameters were less than 150 nm. The average diameter of mPEGseseCe6PBAP nanophotosensitizers was 92.7 ± 9.6 nm in particle size analysis. When H2O2 was added to the nanophotosensitizer solution, nanophotosensitizers were sensitively disintegrated according to the H2O2 concentration and then changed from monomodal distribution to multimodal distribution in particle size distribution. Furthermore, Ce6 release from nanophotosensitizers also increased according to the H2O2 concentration. When H2O2 was added to cell culture of HeLa human cervical cancer cells, intracellular Ce6 uptake of nanophotosensitizers were gradually increased according to the H2O2 concentration, indicating that nanophotosensitizers showed ROS-sensitive delivery of Ce6 against cancer cells.As well as free Ce6, nanophotosensitizers in the absence of light irradiation have low intrinsic cytotoxicity against RAW264.7 cells and HeLa cells. However, nanophotosensitizers induced cell death dose-dependently under light irradiation. Especially, nanophotosensitizers showed significantly higher ROS generation and phototoxicity against HeLa cells in vitro. When nanophotosensitizers were intravenously administered to animal tumor xenograft model of HeLa cells, tumor tissues revealed stronger fluorescence intensity than other tissues by light irradiation while absence of light irradiation induced relatively lower fluorescence intensity in tumor tissues, indicating that nanophotosensitizers have sensitivity against oxidative stress in tumor tissues. We suggest that nanophotosensitizers of mPEGseseCe6PBAP conjugates are promising vehicle for PDT of cervical cancer cells.

Published
2022

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