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491 results on '"Younes, Mamoun"'

3. Ensuring remote diagnostics for pathologists: an open letter to the US Congress

Author

Lennerz, Jochen K., Pantanowitz, Liron, Amin, Mitual B., Eltoum, Isam-Eldin, Hameed, Meera R., Kalof, Alexana N., Khanafshar, Elham, Kunju, Lakshmi P., Lazenby, Audrey J., Montone, Kathleen T., Otis, Christopher N., Reid, Michelle D., Staats, Paul N., Whitney-Miller, Christa L., Abendroth, Catherine S., Aron, Manju, Birdsong, George G., Bleiweiss, Ira J., Bronner, Mary P., Chapman, Jennifer, Cipriani, Nicole A., de la Roza, Gustavo, Esposito, Michael J., Fadare, Oluwole, Ferrer, Karen, Fletcher, Christopher D., Frishberg, David P., Garcia, Fernando U., Geldenhuys, Laurette, Gill, Ryan M., Gui, Dorina, Halat, Shams, Hameed, Omar, Hornick, Jason L., Huber, Aaron R., Jain, Dhanpat, Jhala, Nirag, Jorda, Merce, Jorns, Julie M., Kaplan, Jeffrey, Khalifa, Mahmoud A., Khan, Ashraf, Kim, Grace E., Lee, Eun Y., LiVolsi, Virginia A., Longacre, Teri, Magi-Galluzzi, Cristina, McCall, Shannon J., McPhaul, Laron, Mehta, Vikas, Merzianu, Mihai, Miller, Stacey B., Molberg, Kyle H., Moreira, Andre L., Naini, Bita V., Nosé, Vania, O’Toole, Kathleen, Picken, Maria, Prieto, Victor G., Pullman, James M., Quick, Charles M., Reynolds, Jordan P., Rosenberg, Andrew E., Schnitt, Stuart J., Schwartz, Mary R., Sekosan, Marin, Smith, Michael T., Sohani, Aliyah, Stowman, Anne, Vanguri, Vijay K., Wang, Beverly, Watts, John C., Wei, Shi, Whitney, Kathleen, Younes, Mamoun, Zee, Sui, and Bracamonte, Erika R.

Published
2022
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4. Telomere dysfunction instigates inflammation in inflammatory bowel disease

Author

Chakravarti, Deepavali, Lee, Rumi, Multani, Asha S., Santoni, Andrea, Keith, Zachery, Hsu, Wen-Hao, Change, Kyle, Reyes, Laura, Rashid, Asif, Wu, Chang-Jiun, Li, Jun, Zhang, Jiexin, Shim, Hong Seok, Chandra, Krishna, Deng, Pingna, Spring, Denise J., Nielsen, Ole Haagen, Riis, Lene Buhl, Mayigegowda, Kavya Kelagere, Blutt, Sarah E., Zhang, Jianhua, Younes, Mamoun, DuPont, Andrew, Thirumurthi, Selvi, Vilar, Eduardo, Estes, Mary K., Colla, Simona, Shroyer, Noah F., and DePinho, Ronald A.

Published
2021

8. p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia

Author

Hendley, Audrey M, Wang, Yue J, Polireddy, Kishore, Alsina, Janivette, Ahmed, Ishrat, Lafaro, Kelly J, Zhang, Hao, Roy, Nilotpal, Savidge, Samuel G, Cao, Yanna, Hebrok, Matthias, Maitra, Anirban, Reynolds, Albert B, Goggins, Michael, Younes, Mamoun, Iacobuzio-Donahue, Christine A, Leach, Steven D, and Bailey, Jennifer M

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Digestive Diseases, Rare Diseases, Pancreatic Cancer, Cancer, 2.1 Biological and endogenous factors, Aetiology, Animals, Apoptosis, Biomarkers, Tumor, Blotting, Western, Carcinoma in Situ, Carcinoma, Pancreatic Ductal, Catenins, Cell Proliferation, Epithelial Cells, Humans, Metaplasia, Mice, Mice, Inbred C57BL, Mice, Transgenic, NF-kappa B, Neoplasm Invasiveness, Neoplasm Staging, Pancreatic Neoplasms, Prognosis, RNA, Messenger, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Tumor Cells, Cultured, Delta Catenin, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Aberrant regulation of cellular extrusion can promote invasion and metastasis. Here, we identify molecular requirements for early cellular invasion using a premalignant mouse model of pancreatic cancer with conditional knockout of p120 catenin (Ctnnd1). Mice with biallelic loss of p120 catenin progressively develop high-grade pancreatic intraepithelial neoplasia (PanIN) lesions and neoplasia accompanied by prominent acute and chronic inflammatory processes, which is mediated, in part, through NF-κB signaling. Loss of p120 catenin in the context of oncogenic Kras also promotes remarkable apical and basal epithelial cell extrusion. Abundant single epithelial cells exit PanIN epithelium basally, retain epithelial morphology, survive, and display features of malignancy. Similar extrusion defects are observed following p120 catenin knockdown in vitro, and these effects are completely abrogated by the activation of S1P/S1pr2 signaling. In the context of oncogenic Kras, p120 catenin loss significantly reduces expression of genes mediating S1P/S1pr2 signaling in vivo and in vitro, and this effect is mediated at least, in part, through activation of NF-κB. These results provide insight into mechanisms controlling early events in the metastatic process and suggest that p120 catenin and S1P/S1pr2 signaling enhance cancer progression by regulating epithelial cell invasion. Cancer Res; 76(11); 3351-63. ©2016 AACR.

Published
2016

13. The Significance of So-Called Equivocal Immunohistochemical Staining for Cytomegalovirus in Colorectal Biopsies

Author

Ambelil, Manju, Saulino, David M., Ertan, Atilla, DuPont, Andrew W., and Younes, Mamoun

Subjects
Antiviral agents, Immunohistochemistry, Cytomegalovirus infections, Polymerase chain reaction, Health
Abstract

* Context.--Recent studies examining immunohistochemical staining of colorectal biopsies for cytomegalovirus (CMV) reported that some cases showed only occasional small positive nuclei that were called equivocal for CMV. Objectives.--To determine the extent and clinical significance of equivocal CMV staining in colorectal biopsies. Design.--Two-hundred twenty-one consecutive cases of colon and rectal biopsies that were stained for CMV by immunohistochemistry were retrieved from our files and reviewed. Staining results were recorded as negative, unequivocal, or equivocal. Results were correlated with clinicopathologic data, results of polymerase chain reaction studies for CMV, and treatment history. Results.--Fifty-two cases (24% of all tested, 63% of positive cases) showed equivocal staining for CMV, and of these, 41 had follow-up information. Polymerase chain reaction for CMV was performed largely on blood samples and was not found to be sensitive for the detections of CMV proctocolitis. Of 25 patients who received antiviral treatment, 21 (84%) had complete resolution of symptoms, compared with 8 of 16 (50%) who did not receive antivirals (P =.02). There was no statistically significant difference in response to antiviral drugs in patients with equivocal and unequivocal CMV staining (P =.17). Conclusions.--Equivocal CMV staining likely represents true CMV proctocolitis. Prospective studies are needed to confirm these findings. (Arch Pathol Lab Med. 2019;143:985-989; doi: 10.5858/arpa.2018-0235-OA), Cytomegalovirus (CMV), a double-stranded DNA virus belonging to the human herpesvirus family, is known to cause infection in both immune-competent and immunocompromised individuals. (1) Cytomegalovirus remains a major viral pathogen [...]

Published
2019
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15. Telomere dysfunction activates YAP1 to drive tissue inflammation

Author

Chakravarti, Deepavali, Hu, Baoli, Mao, Xizeng, Rashid, Asif, Li, Jiexi, Li, Jun, Liao, Wen-ting, Whitley, Elizabeth M., Dey, Prasenjit, Hou, Pingping, LaBella, Kyle A., Chang, Andrew, Wang, Guocan, Spring, Denise J., Deng, Pingna, Zhao, Di, Liang, Xin, Lan, Zhengdao, Lin, Yiyun, Sarkar, Sharmistha, Terranova, Christopher, Deribe, Yonathan Lissanu, Blutt, Sarah E., Okhuysen, Pablo, Zhang, Jianhua, Vilar, Eduardo, Nielsen, Ole Haagen, Dupont, Andrew, Younes, Mamoun, Patel, Kalyani R., Shroyer, Noah F., Rai, Kunal, Estes, Mary K., Wang, Y. Alan, Bertuch, Alison A., and DePinho, Ronald A.

Published
2020
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18. Data from p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia

Author

Hendley, Audrey M., primary, Wang, Yue J., primary, Polireddy, Kishore, primary, Alsina, Janivette, primary, Ahmed, Ishrat, primary, Lafaro, Kelly J., primary, Zhang, Hao, primary, Roy, Nilotpal, primary, Savidge, Samuel G., primary, Cao, Yanna, primary, Hebrok, Matthias, primary, Maitra, Anirban, primary, Reynolds, Albert B., primary, Goggins, Michael, primary, Younes, Mamoun, primary, Iacobuzio-Donahue, Christine A., primary, Leach, Steven D., primary, and Bailey, Jennifer M., primary

Published
2023
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19. Supplemental figure legends from p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia

Author

Hendley, Audrey M., primary, Wang, Yue J., primary, Polireddy, Kishore, primary, Alsina, Janivette, primary, Ahmed, Ishrat, primary, Lafaro, Kelly J., primary, Zhang, Hao, primary, Roy, Nilotpal, primary, Savidge, Samuel G., primary, Cao, Yanna, primary, Hebrok, Matthias, primary, Maitra, Anirban, primary, Reynolds, Albert B., primary, Goggins, Michael, primary, Younes, Mamoun, primary, Iacobuzio-Donahue, Christine A., primary, Leach, Steven D., primary, and Bailey, Jennifer M., primary

Published
2023
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20. Figures S1-S8 from p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia

Author

Hendley, Audrey M., primary, Wang, Yue J., primary, Polireddy, Kishore, primary, Alsina, Janivette, primary, Ahmed, Ishrat, primary, Lafaro, Kelly J., primary, Zhang, Hao, primary, Roy, Nilotpal, primary, Savidge, Samuel G., primary, Cao, Yanna, primary, Hebrok, Matthias, primary, Maitra, Anirban, primary, Reynolds, Albert B., primary, Goggins, Michael, primary, Younes, Mamoun, primary, Iacobuzio-Donahue, Christine A., primary, Leach, Steven D., primary, and Bailey, Jennifer M., primary

Published
2023
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21. Supplemental table 1 from p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia

Author

Hendley, Audrey M., primary, Wang, Yue J., primary, Polireddy, Kishore, primary, Alsina, Janivette, primary, Ahmed, Ishrat, primary, Lafaro, Kelly J., primary, Zhang, Hao, primary, Roy, Nilotpal, primary, Savidge, Samuel G., primary, Cao, Yanna, primary, Hebrok, Matthias, primary, Maitra, Anirban, primary, Reynolds, Albert B., primary, Goggins, Michael, primary, Younes, Mamoun, primary, Iacobuzio-Donahue, Christine A., primary, Leach, Steven D., primary, and Bailey, Jennifer M., primary

Published
2023
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22. Pancreatic Acinar Metaplasia in Distal Esophageal Biopsies Is Associated With Chronic Nonsteroidal Anti-inflammatory Drug Use

Author

Salihi, Suhair Al, Jaitly, Vanya, Saulino, David M., DuPont, Andrew W., Ertan, Atilla, Everett, Jamie M., and Younes, Mamoun

Subjects
Nonsteroidal anti-inflammatory agents -- Dosage and administration, Digestive system cancer -- Research -- Drug therapy, Anti-inflammatory agents, Genetic disorders, Inflammation, Myocarditis, Health
Abstract

Context.--The cause of pancreatic acinar metaplasia (PAM) at the distal esophagus/esophagogastric junction is still controversial. Whereas some authors believe it is congenital, others believe it is acquired because of inflammation of the gastric cardia, and more recently it was proposed to be due to chronic proton pump inhibitor use based on a study in rats. Objective.--To determine whether there is correlation between chronic proton pump inhibitor use and PAM in humans. We also investigated the correlation between several clinical and pathologic factors and PAM. Design.--Four hundred forty-four consecutive biopsies from the distal esophagus/esophagogastric junction were reviewed for the presence of PAM, which was then correlated with several clinical and pathologic findings. Results.--Pancreatic acinar metaplasia was found in 71 patients (16%). Pancreatic acinar metaplasia was significantly associated with patient age younger than 51 years (P < .001), chronic carditis (P = .01), and chronic proton pump inhibitor use (P = .008). Surprisingly, we also found significant association between pAm and chronic nonsteroidal anti-inflammatory drug use (P < .001). These associations, including that with chronic nonsteroidal anti-inflammatory drug use, remained significant in multivariate analysis. Conclusions.--Our findings confirm the previous reports of significant association between PAM and chronic carditis and the findings from animal studies of association with chronic proton pump inhibitor use. The strong association with chronic nonsteroidal anti-inflammatory drug use has not been previously reported and warrants further studies. (Arch Pathol Lab Med. 2019;143:510-512; doi: 10.5858/arpa.2018-0152-0A), Pancreatic acinar metaplasia (PAM), also called pancreatic acinar cell metaplasia, is defined as the presence of islands of glandular tissue forming acini composed of cells with coarse apical eosinophilic granules, [...]

Published
2019
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30. Hepatic circadian and differentiation factors control liver susceptibility for fatty liver disease and tumorigenesis

Author

Fekry, Baharan, primary, Ribas‐Latre, Aleix, additional, Drunen, Rachel Van, additional, Santos, Rafael Bravo, additional, Shivshankar, Samay, additional, Dai, Yulin, additional, Zhao, Zhongming, additional, Yoo, Seung‐hee, additional, Chen, Zheng, additional, Sun, Kai, additional, Sladek, Frances M., additional, Younes, Mamoun, additional, and Eckel‐Mahan, Kristin, additional

Published
2022
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35. Pancreatic stromal Gremlin 1 expression during pancreatic tumorigenesis

Author

Davis, Joy M., primary, Cheng, Binglu, additional, Drake, Madeline M., additional, Yu, Qiang, additional, Yang, Baibing, additional, Li, Jing, additional, Liu, Chunhui, additional, Younes, Mamoun, additional, Zhao, Xiurong, additional, Bailey, Jennifer M., additional, Shen, Qiang, additional, Ko, Tien C., additional, and Cao, Yanna, additional

Published
2022
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45. Frozen section of the gastrointestinal tract, appendix, and peritoneum

Author

Younes, Mamoun

Subjects
Frozen tissue sections -- Evaluation, Gastrointestinal diseases -- Diagnosis, Gastrointestinal diseases -- Physiological aspects, Appendix (Anatomy) -- Evaluation, Appendix (Anatomy) -- Physiological aspects, Peritoneum -- Evaluation, Peritoneum -- Physiological aspects
Published
2005

47. Differential Trends in the Intestinal and Diffuse Types of Gastric Carcinoma in the United States, 1973u2000: Increase in the Signet Ring Cell Type

Author

Henson, Donald Earl, Dittus, Christopher, Younes, Mamoun, Nguyen, Hong, and Albores-Saavedra, Jorge

Subjects
Market trend/market analysis, United States. National Cancer Institute -- Research, Stomach cancer -- Development and progression, Stomach cancer -- Forecasts and trends, Stomach cancer -- Diagnosis, Americans -- Health aspects
Published
2004

49. Barrettʼs esophagus: histology and immunohistology

Author

Barr, Hugh, Upton, Melissa P., Orlando, Roy C., Armstrong, David, Vieth, Michael, Neumann, Helmut, Langner, Cord, Wiley, Elizabeth L., Das, Kiron M., Pickett-Blakely, Octavia E., Bajpai, Manisha, Amenta, Peter S., Bennett, Ana, Going, James J., Younes, Mamoun, Wang, Helen H., Taddei, Antonio, Freschi, Giancarlo, Ringressi, Maria Novella, DegliʼInnocenti, Duccio Rossi, Castiglione, Francesca, and Bechi, Paolo

Published
2011
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