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Yongfei You,1 Panpan Wang,1 Xi Wan,2 Liping Xu,3 Yi Gong,4 Weihua Zhang1 1Department of Oncology, The First Hospital of Nanchang, Nanchang, Jiangxi, 330008, People’s Republic of China; 2Operating Room, The First Hospital of Nanchang, Nanchang, Jiangxi, 330008, People’s Republic of China; 3Department of Pathology, The First Hospital of Nanchang, Nanchang, Jiangxi, 330008, People’s Republic of China; 4Department of Imaging, The First Hospital of Nanchang, Nanchang, Jiangxi, 330008, People’s Republic of ChinaCorrespondence: Yongfei YouDepartment of Oncology, The First Hospital of Nanchang, Xiangshan North Road, Donghu District, Nanchang, Jiangxi, 330008, People’s Republic of ChinaTel +86 15070836919Email 59185325@qq.comAbstract: Salivary duct carcinoma (SDC) is a rare and aggressive malignancy with high rates of recurrence and metastasis. There are no standard treatment options available for patients with recurrence and metastases. The case of a 61-year-old male with SDC of the left parotid gland is presented in this study. The results revealed that the patient’s tumour had strong positive staining for androgen receptor (AR) expression, mutations in HRAS and PIK3CA but not in other related genes, and no gene amplification of HER-2. After the primary therapy of parotidectomy with neck dissection and postoperative radiation, bone metastases were found in the ribs, pelvis and spine. Androgen deprivation therapy (ADT) involving combined androgen blockade (CAB) was effective as the first-line therapy for the patient’s metastases and resulted in a progression-free survival (PFS) of over 7 months to date. In conclusion, androgen deprivation therapy is recommended for patients with recurrent or metastatic SDC positive for androgen receptor expression.Keywords: salivary duct carcinoma, androgen receptor, androgen deprivation therapy, case report

Plant community structure characteristics are affected by its habitat. Plant community structure characteristics with different elevations and districts are different because of the unique hydrological condition of the Three Gorges Reservoir( TGR) and geographical condition of different districts. Low( L),Middle( M) and High( H) of typical water-level-fluctuating zone( WLFZ) divided depending on different spacing water level elevations( 145-155 m,155-170 m,170-175 m),were investigated in TGR in order to understand the herbaceous composition,diversity and synusia structure. In the 49 herbaceous species identified,only 4,18and 45 species were present in the L,M and H,respectively. The herb coverage,average density and average height of WLFZ of different water level elevations were( 2. 58% ± 1. 29%)-( 74. 83% ± 2. 57%),( 43. 58 ± 85. 93)-( 466. 08 ± 48. 04) shoots /m2and( 4. 89 ± 0. 56)-( 77. 02 ± 9. 31) cm,respectively. Comprehensive analysis shows that the composition of herbaceous plant species and synusia structure of WLFZ tend to be simple. The species diversity and structure characteristics vary along with water level elevation for different flooding stress and different stages of succession. Our results suggest that the classification of species collocation and optimization of interspecific relationship would be an effective measure for improving herbaceous plants development in the WLFZ.