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Your search keyword '"Yoshiyuki Nishida"' showing total 11 results
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11 results on '"Yoshiyuki Nishida"'

1. Gargle sample is an effective option in a novel fully automated molecular point-of-care test for influenza: a multicenter study

Author

Norihito Kaku, Tomohito Urabe, Tetsuya Iida, Chyuns Yun, Yoshiyuki Nishida, Yasunori Onitsuka, Kohji Hashiguchi, Kiyoto Hirose, Akimitsu Tomonaga, Koichi Izumikawa, Hiroshi Mukae, and Katsunori Yanagihara

Subjects
Rapid detection, Influenza, TRC method, RT-PCR, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background We conducted a multicenter study to evaluate the performance of a novel fully automated molecular point-of-care test using transcription-reverse transcription concerted reaction that can detect influenza A and B within 15 min in nasopharyngeal swabs and gargle samples (TRCsatFLU). Methods Patients who visited or were hospitalized at eight clinics and hospitals with influenza-like illnesses between December 2019 and March 2020 participated in this study. We collected nasopharyngeal swabs from all patients and gargle samples from patients whom the physician judged fit to perform gargling. The result of TRCsatFLU was compared to a conventional reverse transcription-polymerase chain reaction (RT-PCR). If the results of TRCsatFLU and conventional RT-PCR were different, the samples were analyzed by sequencing. Results We evaluated 233 nasopharyngeal swabs and 213 gargle samples from 244 patients. The average age of the patients was 39.3 ± 21.2. Of the patients, 68.9% visited a hospital within 24 h of symptom onset. The most common symptoms were fever (93.0%), fatigue (79.5%), and nasal discharge (64.8%). All patients in whom the gargle sample was not collected were children. Influenza A or B was detected in 98 and 99 patients in nasopharyngeal swabs and gargle samples using TRCsatFLU, respectively. Four and five patients in nasopharyngeal swabs and gargle samples, respectively, with different TRCsatFLU and conventional RT-PCR results. Influenza A or B was detected using sequencing in all samples with different results. Based on the combined conventional RT-PCR and sequencing results, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of TRCsatFLU for influenza detection in nasopharyngeal swabs were 0.990, 1.000, 1.000, and 0.993, respectively. In the gargle samples, the sensitivity, specificity, PPV, and NPV of the TRCsatFLU for detecting influenza were 0.971, 1.000, 1.000, and 0.974, respectively. Conclusions The TRCsatFLU showed great sensitivity and specificity for the detection of influenza in nasopharyngeal swabs and gargle samples. Trial registration : This study was registered in the UMIN Clinical Trials Registry (reference number: UMIN000038276) on October 11, 2019. Before sample collection, written informed consent for the participation and publication of this study was obtained from all participants.

Published
2023
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2. Two cases of adult T-cell leukaemia/lymphoma with oesophageal involvement

Author

Kunihiko Murase, Hirotoshi Fukuda, Katsuhisa Omagari, Hajime Isomoto, Yuji Matsuo, Shigeru Kohno, Yoshiyuki Nishida, Yohei Mizuta, and Ikuo Murata

Subjects
Pathology, medicine.medical_specialty, Adult T-cell leukaemia/lymphoma, Endoscopy, Gastrointestinal, Polypoid Lesion, Esophagus, Fatal Outcome, immune system diseases, hemic and lymphatic diseases, Humans, Leukemia-Lymphoma, Adult T-Cell, Medicine, Neoplasm Invasiveness, Hepatology, business.industry, Esophageal disease, Gastroenterology, Combination chemotherapy, Middle Aged, medicine.disease, Immunohistochemistry, digestive system diseases, Lymphoma, medicine.anatomical_structure, Gastric Mucosa, Female, Viral disease, business, Complication
Abstract

We describe two cases of adult T-cell leukaemia/lymphoma (ATLL) with oesophageal involvement. The first case, a 51-year-old Japanese woman with an acute subtype of ATLL, had an irregular ulcerative lesion in the distal oesophagus. The second case, a 76-year-old Japanese man with a lymphoma subtype of ATLL, had a polypoid lesion in the middle portion of the oesophagus. Both cases had gastric involvement. Biopsies from these lesions revealed mucosal invasion of ATLL cells in each case. Combination chemotherapy was ineffective in both cases. Prospective and careful examination of additional cases may eventually provide specific advice for treatment of this unusual condition.

Published
2002

3. Familial Crohn's disease with systemic lupus erythematosus

Author

Shigeru Kohno, Kunihiko Murase, Kazuya Makiyama, Yohei Mizuta, Yoshiyuki Ozono, Yoshiyuki Nishida, Ryuichi Ashida, Osamu Sasaki, and F Takeshima

Subjects
Adult, Systemic disease, Pathology, medicine.medical_specialty, Gastroenterology, Crohn Disease, immune system diseases, Sulfasalazine, Internal medicine, medicine, Humans, Lupus Erythematosus, Systemic, Microhematuria, skin and connective tissue diseases, Crohn's disease, Lupus erythematosus, Hepatology, business.industry, Perianal Abscess, medicine.disease, medicine.icd_9_cm_classification, Connective tissue disease, Pancytopenia, digestive system diseases, Pedigree, Female, business, medicine.drug
Abstract

We describe a young Japanese woman who was diagnosed with Crohn's disease affecting the ileum, transverse colon, and rectum, as confirmed by barium studies, colonoscopy, and histopathological examination. Her father and sister also had Crohn's disease. After a 4-yr course of sulfasalazine and elemental diet therapy, she was readmitted for perianal abscess associated with the presence of pancytopenia, microhematuria with granular cast, hypocomplementemia, and high titers of autoimmune antibodies (anti-ANA and anti-dsDNA antibodies). Based on these features, a diagnosis of systemic lupus erythematosus (SLE) was made. Despite the rarity of such combination (Crohn's disease with SLE), patients with Crohn's disease who develop such clinical findings might need evaluation for SLE.

Published
1998

4. Different distribution of mast cells and macrophages in colonic mucosa of patients with collagenous colitis and inflammatory bowel disease

Author

Yoshiyuki, Nishida, Kunihiko, Murase, Hajime, Isomoto, Hisashi, Furusu, Yohei, Mizuta, Robert H, Riddell, and Shigeru, Kohno

Subjects
Adult, Crohn Disease, Macrophages, Humans, Colitis, Ulcerative, Collagen, Mast Cells, Intestinal Mucosa, Middle Aged, Colitis, Immunohistochemistry
Abstract

Chronic inflammatory cells in colonic mucosa is a histopathologic feature in patients with collagenous colitis and inflammatory bowel disease. The aim of this study was to compare the distribution of mast cells and macrophages in the colonic mucosa of patients with collagenous colitis, Crohn's disease, and ulcerative colitis.Patients with histologically confirmed collagenous colitis (n = 13), Crohn's disease (n = 20) or ulcerative colitis (n = 20) and normal control patients (n = 20) were included in this study. Biopsy specimens were obtained from the sigmoid colon of each patient, and immunostained using antibodies to tryptase (AA1) and CD68. The number of mast cells and macrophages located in upper and lower part of the lamina propria was determined.The number of mast cells in the upper part of lamina propria in patients with collagenous colitis (286 +/- 89/mm2, mean +/- SD), Crohn's disease (330 +/- 84/mm2) and ulcerative colitis (355 +/- 90/mm2), was higher than normal controls (201 +/- 44/mm2). The number of mast cells in the lower part of lamina propria in patients with Crohn's disease (345 +/- 87/mm2) and ulcerative colitis (363 +/- 86/mm2) was higher than collagenous colitis (266 +/- 63/mm2) and normal controls (309 +/- 60/mm2). The number of macrophages in the lower part of lamina propria in patients with Crohn's disease (330 +/- 63/mm2) and ulcerative colitis (301 +/- 60/mm2) was higher than in collagenous colitis (247 +/- 46/mm2) and normal controls (242 +/- 52/mm2), although there were no significant differences in the number of macrophages present in the upper part of the lamina propria among the four groups.Our data showed the presence of a different distribution of mast cells and macrophages in collagenous colitis and inflammatory bowel disease, and these suggest that because mucosal mast cells have been implicated in the development of Th2 response collagenous colitis is more of a Th2 type reaction rather than Th1.

Published
2002

5. Simultaneous malt lymphoma of stomach, duodenum, and colon

Author

Hajime Isomoto, Kazuo Ohba, Chika Kusakari, Shigeru Kohno, Jiro Yamasaki, and Yoshiyuki Nishida

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, MALT lymphoma, Lymphoma, B-Cell, Marginal Zone, medicine.disease, Stomach duodenum, Duodenal Neoplasms, Stomach Neoplasms, Internal medicine, Colonic Neoplasms, medicine, Humans, Female, Radiology, Nuclear Medicine and imaging, business, Duodenal Neoplasm, Aged
Published
2003

7. Relaxation mechanism of excited acridine in nonreactive solvents

Author

Sadaaki Yamamoto, Hiroshi Kokubun, Yoshiyuki Nishida, Koichi Kikuchi, Koji Ujiie, and Kunihiko Kasama

Subjects
chemistry.chemical_compound, Chemistry, Excited state, Acridine, General Engineering, Relaxation (physics), Physical and Theoretical Chemistry, Photochemistry, Mechanism (sociology)
Published
1981

8. Protolytic reactions of acridine in the triplet state

Author

Yoshiyuki Nishida, Hiroshi Kokubun, and Koichi Kikuchi

Subjects
Aqueous solution, Absorption spectroscopy, Chemistry, General Chemical Engineering, General Physics and Astronomy, Protonation, General Chemistry, Photochemistry, Ion, chemistry.chemical_compound, Reaction rate constant, Deprotonation, Acridine, Triplet state
Abstract

The triplet—triplet (T—T) absorption spectrum of the acridinium ion (λmax=490 nm) was measured in acidic aqueous solution at pH 1.0 by means of the triplet energy transfer from the disodium salt of naphthalene disulphonic acid to the acridinium ion. The triplet acridinium ion decays by a first order process with a rate constant of 1.5 × 103 s−1 at a pH below about 3.8. The pKa of acridine in the triplet state was determined to be 5.6 at 23°C from the measurements of T—T absorption spectra of both the acridine molecule and the acridinium ion. The rate constants for protonation and deprotonation in the triplet state were determined to be (3.4 – 3.8) × 1010 M−1 s−1 and (8.5 – 9.5) × 104 s−1 respectively.

Published
1980

9. PHOTOREDUCTION OF METHYLENE BLUE BOUND TO SODIUM DODECYLE SULFATE MICELLES

Author

Setsuko Kodera, Yoshiharu Usui, and Yoshiyuki Nishida

Subjects
chemistry.chemical_compound, chemistry, Ionic strength, Sodium, Inorganic chemistry, chemistry.chemical_element, Quantum yield, Concentration effect, General Chemistry, Sulfate, Sodium dodecyl sulfate, Micelle, Methylene blue
Abstract

Photochemical reduction of methylene blue bound to sodium dodecyl sulfate micelles is inhibited in a given concentration range of a reductant (EDTA). The concentration dependence of EDTA on the quantum yield shows a sigmoidal type, which is explained by the mechanistic interpretations consisting of the ionic strength effect and the essential concentration effect of EDTA.

Published
1976

10. Vinyl Polymerization. 368. Polymerization of Methyl Methacrylate with the System of RNA, Water and Cu(II) Ion

Author

Minoru Imoto, Toshiyuki Yoshikawa, Tatsuro Ouchi, and Yoshiyuki Nishida

Subjects
Reaction mechanism, Chemistry, Radical polymerization, food and beverages, RNA, General Chemistry, Photochemistry, Ion, chemistry.chemical_compound, Polymerization, Polymer chemistry, Urea, Methyl methacrylate, Ionic polymerization
Abstract

The radical polymerization of methyl methacrylate (MMA) was carried out with the system of ribonucleic acid (RNA), Cu(II) ion and water. The generation of free radical was found to take place in the water layer where RNA and Cu(II) ion exist. Urea shows a promoting activity. The effects of pH of water medium and temperature on the conversion of MMA were investigated. A reaction mechanism was proposed.

Published
1978

11. ORAL ADMINISTRATION OF α-LIPOIC ACID INCREASES SERUM LEVELS OF ASCORBIC ACID AND TOCOPHEROL: A PILOT HEMATOLOGICAL STUDY.

Author

Tetsuyuki Takahashi, Hayato Baba, Hideki Hatta, Hirohisa Ogawa, Hisanori Uehara, Yoshiyuki Nishida, Iwao Kataguchi, and Koichi Tsuneyama

Subjects
*ORAL drug administration, *LIPOIC acid, *SERUM, *VITAMIN C, *VITAMIN E, *HEMATOLOGY
Abstract

The aim of this study was to determine whether oral administration of a-lipoic acid, an intrinsic antioxidant, influences the blood levels of internal ascorbic acid and tocopherol in humans. Low (200 mg/day) and high (600 mg/day) doses of a-lipoic acid were given four times a day for one month (n = 14 each). Blood was collected and hematological tests were performed before the start and after the end of administration. The levels of serum ascorbic acid and tocopherol in both groups dramatically increased (by nearly two-fold) after administration as compared to those before administration. No marked alteration in oxidative status, hepatic and renal function, or fatmetabolic parameters was observed. These results suggest that a-lipoic acid is a potent antioxidant with potential use in the treatment of several diseases associated with oxidative stress. [ABSTRACT FROM AUTHOR]

Published
2015

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