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In the course of our examination for the alkaloid productivities of Streptomyces strains, Streptomyces sp. NA–15 was found to produce a new alkaloid, pyrindicin, in the culture medium. The strain NA–15 was found to be a variant of Streptomyces griseoflavus and was designated as S. griseoflavus var. pyr indie us nov. var.After the culture conditions for pyrindicin production were studied, pyrindicin was obtained as its hydrochloride (mp 145°C, decomp.) from the cultured broth. The compound was shown to possess weak antimicrobial and several pharmacological activities. The LD50 of the hydrochloride (ip, in mice) was 87 mg/kg.

In the course of our examination for the alkaloid productivities of Streptomyces strains, Streptomyces sp. NA–15 was found to produce a new alkaloid, pyrindicin, in the culture medium. The strain NA–15 was found to be a variant of Streptomyces griseoflavus and was designated as S. griseoflavus var. pyr indie us nov. var.After the culture conditions for pyrindicin production were studied, pyrindicin was obtained as its hydrochloride (mp 145°C, decomp.) from the cultured broth. The compound was shown to possess weak antimicrobial and several pharmacological activities. The LD50 of the hydrochloride (ip, in mice) was 87 mg/kg.

Pyrindicin isolated from Streptomyces griseofluvus var. pyrindicus is determined to be 5-(trans-1'-butenyl)-3-methyl-3, 4, 6, 7-tetrahydro-2H-1-pyrindine by its chemical reactions and the physico-chemical methods.

An alkaloid from Streptomyces sp. NA-337, whose structure was assigned previously as (E, E)-4-methyl-2-pentadienyl-1-pyrroline, is re-investigated and revised as (E, E)-2-pentadienyl-3, 4, 5, 6-tetrahydropyridine.