251 results on '"Yoshitake Yamada"'
Search Results
2. Upright CT-based evaluation of the effects of posture on skull-base reconstruction after endoscopic endonasal surgery
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Kento Takahara, Katsuhiro Mizutani, Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Keisuke Yoshida, Kenzo Kosugi, Ryo Ueda, Masahiro Toda, and Masahiro Jinzaki
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CSF leakage ,Endoscopic endonasal skull-base surgery ,Postural changes ,Reconstructed skull base ,Medicine ,Science - Abstract
Abstract Cerebrospinal fluid (CSF) leakage is a common complication associated with endoscopic endonasal skull-base surgery (EESBS). Postoperative mobilization-associated postural changes are considered to cause CSF leakage. However, no study has demonstrated a robust relationship between postural changes and CSF leakage. We used upright computed tomography (CT) to clarify the effects of postural changes on the reconstructed skull base (RSB) after EESBS. Thirty patients who underwent EESBS at our institution were prospectively included, and their upright and supine CTs were compared to measure morphological changes in the RSB. Patient clinical data were also collected from medical charts and surgical videos, and their relationships with morphological changes were assessed. In upright CTs, the RSB shifted intracranially by 0.94 (0.0–2.9) mm on average. This shift was larger in cases with lesions extending to the sphenoid sinus, dural defects, intraoperative pulsation of the RSB, and large bone windows. The direction of the change was opposite to intuitive movement driven by gravity because of reduced intracranial pressure in the sitting position. Thus, these shifts can be directly associated with postoperative CSF leakage caused by reconstruction material displacement. Skull-base reconstruction and postoperative postural management accounting for these morphological changes may be necessary for preventing CSF leakage.
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- 2024
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3. Verification of acromion marker cluster and scapula spinal marker cluster methods for tracking shoulder kinematics: a comparative study with upright four-dimensional computed tomography
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Yuki Yoshida, Noboru Matsumura, Yoshitake Yamada, Azusa Miyamoto, Satoshi Oki, Minoru Yamada, Yoichi Yokoyama, Masaya Nakamura, Takeo Nagura, and Masahiro Jinzaki
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Attachment position ,Scapula spine ,Biomechanics ,Shoulder motion ,Scapular tracking ,Motion capture ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background This study validated the accuracy of the acromion marker cluster (AMC) and scapula spinal marker cluster (SSMC) methods compared with upright four-dimensional computed tomography (4DCT) analysis. Methods Sixteen shoulders of eight healthy males underwent AMC and SSMC assessments. Active shoulder elevation was tracked using upright 4DCT and optical motion capture system. The scapulothoracic and glenohumeral rotation angles calculated from AMC and SSMC were compared with 4DCT. Additionally, the motion of these marker clusters on the skin with shoulder elevation was evaluated. Results The average differences between AMC and 4DCT during 10°−140° of humerothoracic elevation were − 2.2° ± 7.5° in scapulothoracic upward rotation, 14.0° ± 7.4° in internal rotation, 6.5° ± 7.5° in posterior tilting, 3.7° ± 8.1° in glenohumeral elevation, − 8.3° ± 10.7° in external rotation, and − 8.6° ± 8.9° in anterior plane of elevation. The difference between AMC and 4DCT was significant at 120° of humerothoracic elevation in scapulothoracic upward rotation, 50° in internal rotation, 90° in posterior tilting, 120° in glenohumeral elevation, 100° in external rotation, and 100° in anterior plane of elevation. However, the average differences between SSMC and 4DCT were − 7.5 ± 7.7° in scapulothoracic upward rotation, 2.0° ± 7.0° in internal rotation, 2.3° ± 7.2° in posterior tilting, 8.8° ± 7.9° in glenohumeral elevation, 2.0° ± 9.1° in external rotation, and 1.9° ± 10.1° in anterior plane of elevation. The difference between SSMC and 4DCT was significant at 50° of humerothoracic elevation in scapulothoracic upward rotation and 60° in glenohumeral elevation, with no significant differences observed in other rotations. Skin motion was significantly smaller in AMC (28.7 ± 4.0 mm) than SSMC (38.6 ± 5.8 mm). Although there was smaller skin motion in AMC, SSMC exhibited smaller differences in scapulothoracic internal rotation, posterior tilting, glenohumeral external rotation, and anterior plane of elevation compared to 4DCT. Conclusion This study demonstrates that AMC is more accurate for assessing scapulothoracic upward rotation and glenohumeral elevation, while SSMC is preferable for evaluating scapulothoracic internal rotation, posterior tilting, glenohumeral external rotation, and anterior plane of elevation, with smaller differences compared to 4DCT.
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- 2024
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4. Gender differences in spinal mobility during postural changes: a detailed analysis using upright CT
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Ryo Mizukoshi, Mitsuru Yagi, Yoshitake Yamada, Yoichi Yokoyama, Minoru Yamada, Kota Watanabe, Masaya Nakamura, Takeo Nagura, and Masahiro Jinzaki
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Gender differences ,Spinal mobility ,Postural changes ,Upright CT ,Lumbar alignment ,Medicine ,Science - Abstract
Abstract Lumbar spinal alignment is crucial for spine biomechanics and is linked to various spinal pathologies. However, limited research has explored gender-specific differences using CT scans. The objective was to evaluate and compare lumbar spinal alignment between standing and sitting CT in healthy individuals, focusing on gender differences. 24 young and 25 elderly males (M) and females (F) underwent standing and sitting CT scans to assess lumbar spinal alignment. Parameters measured and compared between genders included lumbar lordosis (LL), sacral slope (SS), pelvic tilt (PT), pelvic incidence (PI), lordotic angle (LA), foraminal height (FH), and bony boundary area (BBA). Females showed significantly larger changes in SS and PT when transitioning from standing to sitting (p = .044, p = .038). A notable gender difference was also observed in the L4-S LA among the elderly, with females showing a significantly larger decrease in lordotic angle compared to males (− 14.1° vs. − 9.2°, p = .039*). Females consistently exhibited larger FH and BBA values, particularly in lower lumbar segments, which was more prominent in the elderly group (M vs. F: L4/5 BBA 80.1 mm2 [46.3, 97.8] vs. 109.7 mm2 [74.4, 121.3], p = .019 in sitting). These findings underline distinct gender-related variations in lumbar alignment and flexibility, with a focus on noteworthy changes in BBA and FH in females. Gender differences in lumbar spinal alignment were evident, with females displaying greater pelvic and sacral mobility. Considering gender-specific characteristics is crucial for assessing spinal alignment and understanding spinal pathologies. These findings contribute to our understanding of lumbar spinal alignment and have implications for gender-specific spinal conditions and treatments.
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- 2024
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5. Assessment of pulmonary function in COPD patients using dynamic digital radiography: A novel approach utilizing lung signal intensity changes during forced breathing
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Noriaki Wada, Akinori Tsunomori, Takeshi Kubo, Takuya Hino, Akinori Hata, Yoshitake Yamada, Masako Ueyama, Mizuki Nishino, Atsuko Kurosaki, Kousei Ishigami, Shoji Kudoh, and Hiroto Hatabu
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Dynamic digital radiography ,Pulmonary function ,COPD ,Lung signal intensity ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Objectives: To investigate the association of lung signal intensity changes during forced breathing using dynamic digital radiography (DDR) with pulmonary function and disease severity in patients with chronic obstructive pulmonary disease (COPD). Methods: This retrospective study included 46 healthy subjects and 33 COPD patients who underwent posteroanterior chest DDR examination. We collected raw signal intensity and gray-scale image data. The lung contour was extracted on the gray-scale images using our previously developed automated lung field tracking system and calculated the average of signal intensity values within the extracted lung contour on gray-scale images. Lung signal intensity changes were quantified as SImax/SImin, representing the maximum ratio of the average signal intensity in the inspiratory phase to that in the expiratory phase. We investigated the correlation between SImax/SImin and pulmonary function parameters, and differences in SImax/SImin by disease severity. Results: SImax/SImin showed the highest correlation with VC (rs = 0.54, P < 0.0001), followed by FEV1 (rs = 0.44, P < 0.0001), both of which are key indicators of COPD pathophysiology. In a multivariate linear regression analysis adjusted for confounding factors, SImax/SImin was significantly lower in the severe COPD group compared to the normal group (P = 0.0004) and mild COPD group (P=0.0022), suggesting its potential usefulness in assessing COPD severity. Conclusion: This study suggests that the signal intensity changes of lung fields during forced breathing using DDR reflect the pathophysiology of COPD and can be a useful index in assessing pulmonary function in COPD patients, potentially improving COPD diagnosis and management.
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- 2024
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6. Lung volume measurement using chest CT in COVID-19 patients: a cohort study in Japan
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Takanori Kanai, Yukinori Okada, Takanori Asakura, Yukari Kato, Koichi Fukunaga, Tomoki Maetani, Yusuke Shiraishi, Masahiro Jinzaki, Naoya Tanabe, Toyohiro Hirai, Makoto Ishii, Naoki Hasegawa, Takashi Shimada, Ryuji Koike, Shotaro Chubachi, Yoshitake Yamada, Kensuke Nakagawara, Ho Namkoong, Hideki Terai, Hiromu Tanaka, Soichiro Ueda, Norihiro Harada, Hiroki Tateno, Seiya Imoto, Shuhei Azekawa, Shiro Otake, Takahiro Fukushima, Mayuko Watase, Akinori Kimura, Satoru Miyano, Seishi Ogawa, Mamoru Sasaki, Shoji Suzuki, and Shuichi Yoshida
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Medicine ,Diseases of the respiratory system ,RC705-779 - Abstract
Objective This study aimed to investigate the utility of CT quantification of lung volume for predicting critical outcomes in COVID-19 patients.Methods This retrospective cohort study included 1200 hospitalised patients with COVID-19 from 4 hospitals. Lung fields were extracted using artificial intelligence-based segmentation, and the percentage of the predicted (%pred) total lung volume (TLC (%pred)) was calculated. The incidence of critical outcomes and posthospitalisation complications was compared between patients with low and high CT lung volumes classified based on the median percentage of predicted TLCct (n=600 for each). Prognostic factors for residual lung volume loss were investigated in 208 patients with COVID-19 via a follow-up CT after 3 months.Results The incidence of critical outcomes was higher in the low TLCct (%pred) group than in the high TLCct (%pred) group (14.2% vs 3.3%, p
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- 2024
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7. Anatomical cardiac and electrocardiographic axes correlate in both upright and supine positions: an upright/supine CT study
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Togo Norimatsu, Takehiro Nakahara, Yoshitake Yamada, Yoichi Yokoyama, Minoru Yamada, Keiichi Narita, and Masahiro Jinzaki
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Medicine ,Science - Abstract
Abstract The correlation between the anatomical cardiac and electrocardiographic axes has been discussed for several years. Using upright computed tomography, this study aimed to reveal the relationship between the anatomical cardiac and electrocardiographic axes in both the supine and upright positions. Upright CT and standard supine CT were performed for healthy volunteers, following electrocardiography in both upright and supine position. On CT images, the coordinates of apex, the center of aortic valve (AV) and mitral valve (MV) were recorded, and the vectors and angles were calculated. Subcutaneous and visceral fat volume were semi-automatically calculated in a workstation. From a total 190 volunteers, 41 males were performed electrocardiography and included for this study. The QRS and anatomical axes (AV-apex and MV-apex axis) were significantly correlated in both supine and upright positions, while the angle of the AV-apex to Z axis was the most correlated (supine: r = − 0.54, p = 0.0002, upright: r = − 0.47, p = 0.0020). The anatomical axis moved in the dorsal and caudal directions from the supine to upright position. Multiple regression analysis revealed that the anatomical axis from the AV-apex to the Z-axis was determined according to age, body height, subcutaneous and visceral fat volumes.
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- 2023
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8. Clinical utilization of artificial intelligence-based COVID-19 pneumonia quantification using chest computed tomography – a multicenter retrospective cohort study in Japan
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Hiromu Tanaka, Tomoki Maetani, Shotaro Chubachi, Naoya Tanabe, Yusuke Shiraishi, Takanori Asakura, Ho Namkoong, Takashi Shimada, Shuhei Azekawa, Shiro Otake, Kensuke Nakagawara, Takahiro Fukushima, Mayuko Watase, Hideki Terai, Mamoru Sasaki, Soichiro Ueda, Yukari Kato, Norihiro Harada, Shoji Suzuki, Shuichi Yoshida, Hiroki Tateno, Yoshitake Yamada, Masahiro Jinzaki, Toyohiro Hirai, Yukinori Okada, Ryuji Koike, Makoto Ishii, Naoki Hasegawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, and Koichi Fukunaga
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Artificial intelligence (AI)-based analysis ,Computer Vision System ,Pneumonia ,Post-acute COVID-19 syndrome ,SARS-CoV-2 infection ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Computed tomography (CT) imaging and artificial intelligence (AI)-based analyses have aided in the diagnosis and prediction of the severity of COVID-19. However, the potential of AI-based CT quantification of pneumonia in assessing patients with COVID-19 has not yet been fully explored. This study aimed to investigate the potential of AI-based CT quantification of COVID-19 pneumonia to predict the critical outcomes and clinical characteristics of patients with residual lung lesions. Methods This retrospective cohort study included 1,200 hospitalized patients with COVID-19 from four hospitals. The incidence of critical outcomes (requiring the support of high-flow oxygen or invasive mechanical ventilation or death) and complications during hospitalization (bacterial infection, renal failure, heart failure, thromboembolism, and liver dysfunction) was compared between the groups of pneumonia with high/low-percentage lung lesions, based on AI-based CT quantification. Additionally, 198 patients underwent CT scans 3 months after admission to analyze prognostic factors for residual lung lesions. Results The pneumonia group with a high percentage of lung lesions (N = 400) had a higher incidence of critical outcomes and complications during hospitalization than the low percentage group (N = 800). Multivariable analysis demonstrated that AI-based CT quantification of pneumonia was independently associated with critical outcomes (adjusted odds ratio [aOR] 10.5, 95% confidence interval [CI] 5.59–19.7), as well as with oxygen requirement (aOR 6.35, 95% CI 4.60–8.76), IMV requirement (aOR 7.73, 95% CI 2.52–23.7), and mortality rate (aOR 6.46, 95% CI 1.87–22.3). Among patients with follow-up CT scans (N = 198), the multivariable analysis revealed that the pneumonia group with a high percentage of lung lesions on admission (aOR 4.74, 95% CI 2.36–9.52), older age (aOR 2.53, 95% CI 1.16–5.51), female sex (aOR 2.41, 95% CI 1.13–5.11), and medical history of hypertension (aOR 2.22, 95% CI 1.09–4.50) independently predicted persistent residual lung lesions. Conclusions AI-based CT quantification of pneumonia provides valuable information beyond qualitative evaluation by physicians, enabling the prediction of critical outcomes and residual lung lesions in patients with COVID-19.
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- 2023
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9. Cystic fibrosis with multiple pulmonary arteriovenous malformations: A case report
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Orito Ikeda, MD, Kunihiko Shimizu, MD, Yoshitake Yamada, PhD, Hiroaki Sugiura, MD, Hideaki Suzuki, MD, Syuichiro Umetsu, MD, Kozo Sato, MD, and Masahiro Jinzaki, PhD
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Cystic fibrosis ,Pulmonary arteriovenous malformations ,Hypoxemia ,Dynamic CT ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Cystic fibrosis is an autosomal recessive genetic disorder that damages the exocrine function of the body, resulting in alterations of multiple organs. In the respiratory system, it is known to cause bronchiectasis, recurrent bronchitis, and pneumonia; however, to the best of our knowledge, there are no reported cases of pulmonary arteriovenous malformations associated with this disease. Herein, we report a case of cystic fibrosis with multiple pulmonary arteriovenous malformations. A 16-year-old girl, who has been monitored since childhood for pancreatitis of unknown cause, experienced respiratory symptoms and hypoxemia (PaO2 = 57 mmHg). At 13 years of age, chest computed tomography revealed bronchiectasis, bronchial wall thickening, and tree-in-bud sign. Genetic testing was performed, and the patient was diagnosed with cystic fibrosis. However, the computed tomography scan also showed incidental nodular lesions in the left superior and both the inferior pulmonary lobes, suggesting multiple arteriovenous malformations. Dynamic computed tomography was performed which, confirmed the presence of 3 pulmonary arteriovenous malformations. Coil embolization was performed on all lesions, and the hypoxemia was corrected. Marked hypoxemia in a patient with cystic fibrosis may not be explained only by the presence of bronchiectasis and/or bronchial wall thickening; in such cases, it may be necessary to examine possible additional findings on computed tomography images, such as arteriovenous malformations.
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- 2023
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10. Comparison of inspiratory and expiratory airway volumes and luminal areas among standing, sitting, and supine positions using upright and conventional CT
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Yoshitake Yamada, Minoru Yamada, Shotaro Chubachi, Yoichi Yokoyama, Shiho Matsuoka, Akiko Tanabe, Yuki Niijima, Mitsuru Murata, Takayuki Abe, Koichi Fukunaga, and Masahiro Jinzaki
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Medicine ,Science - Abstract
Abstract Upright computed tomography (CT) provides physiologically relevant images of daily life postures (sitting and standing). The volume of the human airway in sitting or standing positions remains unclear, and no clinical study to date has compared the inspiratory and expiratory airway volumes and luminal areas among standing, sitting, and supine positions. In this prospective study, 100 asymptomatic volunteers underwent both upright (sitting and standing positions) and conventional (supine position) CT during inspiration and expiration breath-holds and the pulmonary function test (PFT) within 2 h of CT. We compared the inspiratory/expiratory airway volumes and luminal areas on CT among the three positions and evaluated the correlation between airway volumes in each position on CT and PFT measurements. The inspiratory and expiratory airway volumes were significantly higher in the sitting and standing positions than in the supine position (inspiratory, 4.6% and 2.5% increase, respectively; expiratory, 14.9% and 13.4% increase, respectively; all P
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- 2022
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11. Differences in lung and lobe volumes between supine and upright computed tomography in patients with idiopathic lung fibrosis
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Shotaro Chubachi, Satoshi Okamori, Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Yuki Niijima, Hirofumi Kamata, Makoto Ishii, Koichi Fukunaga, and Masahiro Jinzaki
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Medicine ,Science - Abstract
Abstract No clinical study has compared lung or lobe volumes on computed tomography (CT) between the supine and standing positions in patients with idiopathic lung fibrosis (IPF). This study aimed to compare lung and lobe volumes between the supine and standing positions and evaluate the correlations between the supine/standing lung volumes on CT and pulmonary function in patients with IPF. Twenty-three patients with IPF underwent a pulmonary function test and both low-dose conventional (supine position) and upright CT (standing position) during inspiration breath-holds. The volumes of the total lungs and lobes were larger in the standing than in the supine position in patients with IPF (all p
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- 2022
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12. Separate evaluation of unilateral lung function using upright/supine CT in a patient with diaphragmatic paralysis
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Takahiro Suzuki, MD, Keisuke Asakura, MD, Yoshitake Yamada, MD, Minoru Yamada, PhD, Yoichi Yokoyama, MD, Yu Okubo, MD, Kyohei Masai, MD, Kaoru Kaseda, MD, Tomoyuki Hishida, MD, Hisao Asamura, MD, and Masahiro Jinzaki, MD
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CT ,Diaphragm ,Diagnostic Imaging ,Lung function ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Background: Unilateral diaphragmatic paralysis is a condition in which the unilateral diaphragm is paralyzed and elevated. Orthopnea due to lung compression by an elevated diaphragm in the supine position is common in patients with unilateral diaphragmatic paralysis. Although its symptom is posture-dependent, the effect of posture on lung function in unilateral diaphragmatic paralysis has not been studied. Computed tomography (CT) can be used to assess lung volume. However, conventional CT cannot be performed in the upright position. A pulmonary function test can be performed in both upright and supine positions. However, it cannot evaluate the function of each lung separately. Case presentation: We report a case of a 79-year-old man with unilateral diaphragmatic paralysis. He presented with difficulty in inspiration, specifically in the supine position, and underwent both conventional supine CT and newly developed upright CT to assess the effect of posture on the function of each lung. The difference between expiratory and inspiratory lung volumes on CT in the supine position was less than that in the upright position by 46% and 4% on affected and healthy sides, respectively. We previously reported that the difference between expiratory and inspiratory lung volumes on CT correlated with inspiratory capacity on the pulmonary function test. A 46% decline in inspiratory capacity on the affected side in the supine position likely caused orthopnea in this patient. Conclusions: Supine/upright CT is helpful to assess the influence of posture on unilateral lung function in patients with unilateral diaphragmatic paralysis.
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- 2022
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13. Cranial defect and pneumocephalus are associated with significant postneurosurgical positional brain shift: evaluation using upright computed tomography
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Keisuke Yoshida, Masahiro Toda, Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Kei Tsutsumi, Hirokazu Fujiwara, Kenzo Kosugi, and Masahiro Jinzaki
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Medicine ,Science - Abstract
Abstract Only few studies have assessed brain shift caused by positional change. This study aimed to identify factors correlated with a large postneurosurgical positional brain shift (PBS). Sixty-seven patients who underwent neurosurgical procedures had upright computed tomography (CT) scan using settings similar to those of conventional supine CT. The presence of a clinically significant PBS, defined as a brain shift of ≥ 5 mm caused by positional change, was evaluated. The clinical and radiological findings were investigated to identify factors associated with a larger PBS. As a result, twenty-one patients had a clinically significant PBS. The univariate analysis showed that supratentorial lesion location, intra-axial lesion type, craniectomy procedure, and residual intracranial air were the predictors of PBS. Based on the multivariate analysis, craniectomy procedure (p
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- 2022
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14. Knee varus alters three-dimensional ankle alignment in standing- a study with upright computed tomography
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Satoshi Hakukawa, Kazuya Kaneda, Satoshi Oki, Kengo Harato, Yoshitake Yamada, Yasuo Niki, Takeo Nagura, Masaya Nakamura, and Masahiro Jinzaki
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Hindfoot ,Weightbearing ,Whole legs alignment ,Upright computed tomography ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background For knee osteoarthritis (OA) treatment, it is important to correct the lower limb alignment including the foot. However, in the upright position, lower limb alignment is generally assessed from the body surface or radiographs, and it is a challenge to capture the exact characteristics of three-dimensional lower limb alignment. The purpose of the study was to measure lower limb alignment in patients with knee OA using upright computed tomography (CT) and radiography, and to identify features of knee joint deformity. Methods A total of 45 limbs in 25 patients with knee OA were enrolled. The subjects underwent both upright CT and radiography for the whole lower limb in the standing position. The joint angles were calculated on both images. The degree of knee OA was classified according to Kellgren-Lawrence (KL) grade by referring to radiography, which is mainly based on the degree of articular cartilage loss and severity of osteophytes, and the characteristics or correlation between knee and ankle joint in each group was investigated. Results In KL-I, there was an association between varus of the knee joint and internal rotation of the talocrural joint (r = 0.76, P
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- 2022
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15. Three-dimensional alignment of the upper extremity in the standing neutral position in healthy subjects
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Yuki Yoshida, Noboru Matsumura, Yoshitake Yamada, Satoshi Hiraga, Kazunori Ishii, Satoshi Oki, Yoichi Yokoyama, Minoru Yamada, Masaya Nakamura, Takeo Nagura, and Masahiro Jinzaki
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Neutral posture ,Shoulder ,Elbow ,Scapulothoracic joint ,Glenohumeral joint ,Upright computed tomography ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Though alignment of the spine and lower extremities in the standing neutral position has been evaluated, a few studies evaluating the alignment of the upper extremities have also been made. This study assessed the normal alignment of the upper extremities in the standing neutral position and clarified the three-dimensional angular rotations of the upper extremity joints. Methods Computed tomography (CT) images of 158 upper extremities from 79 healthy volunteers were prospectively acquired in the standing neutral position using an upright CT scanner. Three-dimensional coordinate systems of the thorax, scapula, humerus, and forearm were designated, and three-dimensional angular rotations of the scapulothoracic, glenohumeral, and elbow joints were calculated. Results The median angle of the scapulothoracic joint was 9.2° (interquartile range [IQR], 5.2°–12.5°) of upward rotation, 29.0° (IQR, 24.9°–33.3°) of internal rotation, and 7.9° (IQR, 4.3°–11.8°) of anterior tilt. The median angle of the glenohumeral joint was 4.5° (IQR, 0.9°–7.8°) of abduction, 9.0° (IQR, 2.2°–19.0°) of internal rotation, and 0.3° (IQR, − 2.6°–3.1°) of extension. The median angle of the elbow joint was 9.8° (IQR, 6.9°–12.4°) of valgus, 90.2° (IQR, 79.6°–99.4°) of pronation, and 15.5° (IQR, 13.2°–18.1°) of flexion. Correlations in angular rotation values were found between the right and left upper extremities and between joints. Conclusions This study clarified the three-dimensional angular rotation of upper extremity joints in the standing neutral position using an upright CT scanner. Our results may provide important insights for the functional evaluation of upper extremity alignment.
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- 2022
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16. Increase in tibial internal rotation due to weight-bearing is a key feature to diagnose early-stage knee osteoarthritis: a study with upright computed tomography
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Kazuya Kaneda, Kengo Harato, Satoshi Oki, Yoshitake Yamada, Masaya Nakamura, Takeo Nagura, and Masahiro Jinzaki
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Upright computed tomography ,Early knee osteoarthritis ,Weight-bearing ,Surface registration ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background The classification of knee osteoarthritis is an essential clinical issue, particularly in terms of diagnosing early knee osteoarthritis. However, the evaluation of three-dimensional limb alignment on two-dimensional radiographs is limited. This study evaluated the three-dimensional changes induced by weight-bearing in the alignments of lower limbs at various stages of knee osteoarthritis. Methods Forty five knees of 25 patients (69.9 ± 8.9 years) with knee OA were examined in the study. CT images of the entire leg were obtained in the supine and standing positions using conventional CT and 320-row detector upright CT, respectively. Next, the differences in the three-dimensional alignment of the entire leg in the supine and standing positions were obtained using 3D-3D surface registration technique, and those were compared for each Kellgren–Lawrence grade. Results Greater flexion, adduction, and tibial internal rotation were observed in the standing position, as opposed to the supine position. Kellgren–Lawrence grades 1 and 4 showed significant differences in flexion, adduction, and tibial internal rotation between two postures. Grades 2 and 4 showed significant differences in adduction, while grades 1 and 2, and 1 and 3 showed significant differences in tibial internal rotation between standing and supine positions. Conclusions Weight-bearing makes greater the three-dimensional deformities in knees with osteoarthritis. Particularly, greater tibial internal rotation was observed in patients with grades 2 and 3 compared to those with grade 1. The greater tibial internal rotation due to weight-bearing is a key pathologic feature to detect early osteoarthritic change in knees undergoing osteoarthritis.
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- 2022
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17. Vector-field dynamic x-ray (VF-DXR) using optical flow method in patients with chronic obstructive pulmonary disease
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Takuya Hino, Akinori Tsunomori, Akinori Hata, Tomoyuki Hida, Yoshitake Yamada, Masako Ueyama, Tsutomu Yoneyama, Atsuko Kurosaki, Takeshi Kamitani, Kousei Ishigami, Takenori Fukumoto, Shoji Kudoh, and Hiroto Hatabu
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Lung ,Optic flow ,Pulmonary disease (chronic obstructive) ,Radiography (thoracic) ,Respiratory function tests ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background We assessed the difference in lung motion during inspiration/expiration between chronic obstructive pulmonary disease (COPD) patients and healthy volunteers using vector-field dynamic x-ray (VF-DXR) with optical flow method (OFM). Methods We enrolled 36 COPD patients and 47 healthy volunteers, classified according to pulmonary function into: normal, COPD mild, and COPD severe. Contrast gradient was obtained from sequential dynamic x-ray (DXR) and converted to motion vector using OFM. VF-DXR images were created by projection of the vertical component of lung motion vectors onto DXR images. The maximum magnitude of lung motion vectors in tidal inspiration/expiration, forced inspiration/expiration were selected and defined as lung motion velocity (LMV). Correlations between LMV with demographics and pulmonary function and differences in LMV between COPD patients and healthy volunteers were investigated. Results Negative correlations were confirmed between LMV and % forced expiratory volume in one second (%FEV1) in the tidal inspiration in the right lung (Spearman’s rank correlation coefficient, r s = -0.47, p < 0.001) and the left lung (r s = -0.32, p = 0.033). A positive correlation between LMV and %FEV1 in the tidal expiration was observed only in the right lung (r s = 0.25, p = 0.024). LMVs among normal, COPD mild and COPD severe groups were different in the tidal respiration. COPD mild group showed a significantly larger magnitude of LMV compared with the normal group. Conclusions In the tidal inspiration, the lung parenchyma moved faster in COPD patients compared with healthy volunteers. VF-DXR was feasible for the assessment of lung parenchyma using LMV.
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- 2022
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18. Determining the validity and reliability of spinopelvic parameters through comparing standing whole spinal radiographs and upright computed tomography images
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Naruhito Fujita, Mitsuru Yagi, Kota Watanabe, Masaya Nakamura, Morio Matsumoto, Yoichi Yokoyama, Minoru Yamada, Yoshitake Yamada, Takeo Nagura, and Masahiro Jinzaki
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Upright computed tomography ,Standing whole spinal radiograph ,Spinopelvic parameters ,Adult spinal deformity ,Interclass correlation coefficient ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Standing whole spinal radiographs are used to evaluate spinal alignment in adult spinal deformity (ASD), yet some studies have reported that pelvic incidence, pelvic tilt, and thoracic kyphosis (TK) intra- and inter-observer reliability is low. This study aimed to evaluate the accuracy of spinopelvic parameters through comparing standing whole spinal radiographs and upright CT images. Methods We enrolled 26 patients with ASD. All standing whole spinal posterior/anterior and lateral radiographs and upright whole spinal CT had been obtained in a natural standing position. Two examiners independently measured 13 radiographic parameters. Interclass correlation coefficients (ICCs) were used to analyze measurement intra- and inter-observer reliability. Paired t- and Pearson’s correlation tests were used to analyze validity of the standing whole spinal radiographs. Results ICCs of upright CT were excellent in both intra- and inter-observer reliability. However, intra-observer ICCs for TK2–12, TK1–5, TK2–5, and TK5–12 on standing lateral radiographs were relatively low, as were inter-observer ICCs for TK2–12, TK1–5, TK2–5, and TK5–12. Concerning TK values, the difference between the radiographs and CT in TK1–12 and TK2–12 were 4.4 ± 3.1 and 6.6 ± 4.6, respectively, and TK values from T2 showed greater measurement error (p
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- 2021
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19. Natural History of Leaflet Thrombosis After Transcatheter Aortic Valve Replacement: A 5‐Year Follow‐Up Study
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Shohei Imaeda, Taku Inohara, Nobuhiro Yoshijima, Yusuke Kobari, Sosuke Myojin, Toshinobu Ryuzaki, Osamu Hattori, Keitaro Shinada, Hikaru Tsuruta, Tatsuo Takahashi, Masataka Yamazaki, Jungo Kato, Yoshitake Yamada, Masahiro Jinzaki, Hideyuki Shimizu, Keiichi Fukuda, and Kentaro Hayashida
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aortic valve stenosis ,hypoattenuated leaflet thickening ,transcatheter aortic valve replacement ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Subclinical leaflet thrombosis, characterized by hypoattenuated leaflet thickening (HALT) on multidetector computed tomography, is common after transcatheter aortic valve replacement (TAVR). Because little is known about the long‐term natural history of subclinical HALT, we aimed to investigate this in patients who underwent TAVR without using additional anticoagulation. Methods and Results We retrospectively evaluated patients who underwent TAVR with the Edwards SAPIEN‐XT at our institute between October 2013 and December 2015. Patients were grouped according to the presence or absence of HALT within 1 year after TAVR (HALT and No‐HALT groups). The primary outcome, defined as the composite of all‐cause mortality, heart failure readmission, and ischemic stroke, was compared. Valve performance was assessed over time by transthoracic echocardiography. Among 124 patients (men: 29.1%; median age, 85 years), 27 (21.8%) showed HALT on multidetector computed tomography within 1 year after TAVR. No patient required additional anticoagulation for treating HALT because of the absence of valve‐related symptomatic deterioration. During the median follow‐up period of 4.7 years (interquartile range, 4.0–5.6), the rate of primary outcome and valve performance was not statistically different between the 2 groups (37.0% versus 38.1%; log‐rank test P=0.92; mean pressure gradient, 9 mm Hg [8–14 mm Hg] versus 10 mm Hg [7–15 mm Hg]; P=0.51, respectively). Conclusions Approximately 20% of patients after TAVR had HALT within 1 year; however, that did not change the risk of subsequent adverse cardiovascular events or the valve performance with statistical significance for up to 5 years despite no additional anticoagulation therapy.
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- 2022
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20. Saphenous vein valve assessment utilizing upright CT to potentially improve graft assessment for bypass surgery
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Takehiro Nakahara, Minoru Yamada, Yoichi Yokoyama, Yoshitake Yamada, Keiichi Narita, Nobuaki Imanishi, Masataka Yamazaki, Hideyuki Shimizu, Jagat Narula, and Masahiro Jinzaki
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Medicine ,Science - Abstract
Abstract Saphenous veins (SVs) are frequently employed as bypass grafts. The SV graft failure is predominantly seen at the valve site. Avoiding valves during vein harvest would help reduce graft failure. We endeavored to detect SV valves, tributaries, and vessel size employing upright computed tomography (CT) for the raw cadaver venous samples and in healthy volunteers. Five cadaver legs were scanned. Anatomical analysis showed 3.0 (IQR: 2.0–3.0) valves and 13.50 (IQR: 10.00–16.25) tributaries. The upright CT completely detected, compared to 2.0 (IQR: 1.5–2.5, p = 0.06) valves and 9.5 (IQR: 7.5–13.0, p = 0.13) tributaries by supine CT. From a total of 190 volunteers, 138 (men:75, women:63) were included. The number of valves from the SF junction to 35 cm were significantly higher in upright CT than in supine CT bilaterally [upright vs. supine, Right: 4 (IQR: 3–5) vs. 2 (IQR:1–2), p
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- 2021
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21. Characteristics of chronic obstructive pulmonary disease patients with robust progression of emphysematous change
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Akihiro Tsutsumi, Shotaro Chubachi, Hidehiro Irie, Mamoru Sasaki, Yoshitake Yamada, Hiroaki Sugiura, Masahiro Jinzaki, Hidetoshi Nakamura, Koichiro Asano, Tomoko Betsuyaku, and Koichi Fukunaga
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Medicine ,Science - Abstract
Abstract Emphysema is a major pathological change in chronic obstructive pulmonary disease (COPD). However, the annual changes in the progression of emphysematous have not been investigated. We aimed to determine possible baseline predicting factors of the change in emphysematous progression in a subgroup of COPD patients who demonstrated rapid progression. In this observational study, we analyzed patients with COPD who were followed up by computed tomography (CT) at least two times over a 3-year period (n = 217). We divided the annual change in the low attenuation area percentage (LAA%) into quartiles and defined a rapid progression group (n = 54) and a non-progression group (n = 163). Predictors of future changes in emphysematous progression differed from predictors of high LAA% at baseline. On multivariate logistic regression analysis, low blood eosinophilic count (odds ratio [OR], 3.22; P = 0.04) and having osteoporosis (OR, 2.13; P = 0.03) were related to rapid changes in emphysematous progression. There was no difference in baseline nutritional parameters, but nutritional parameters deteriorated in parallel with changes in emphysematous progression. Herein, we clarified the predictors of changes in emphysematous progression and concomitant deterioration of nutritional status in COPD patients.
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- 2021
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22. Differences in airway lumen area between supine and upright computed tomography in patients with chronic obstructive pulmonary disease
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Shotaro Chubachi, Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Akiko Tanabe, Shiho Matsuoka, Yuki Niijima, Wakako Yamasawa, Hidehiro Irie, Mitsuru Murata, Koichi Fukunaga, and Masahiro Jinzaki
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COPD ,CT ,Pulmonary function test ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background No clinical studies to date have compared the inspiratory and expiratory airway lumen area between supine and standing positions. Thus, the aims of this study were twofold: (1) to compare inspiratory and expiratory airway lumen area (IAA and EAA, respectively) on computed tomography (CT) among supine and standing positions; and (2) to investigate if IAA and EAA are associated with lung function abnormality in patients with chronic obstructive pulmonary disease (COPD). Methods Forty-eight patients with COPD underwent both low-dose conventional (supine position) and upright CT (standing position) during inspiration and expiration breath-holds and a pulmonary function test (PFT) on the same day. We measured the IAA and EAA in each position. Results For the trachea to the third-generation bronchi, the IAA was significantly larger in the standing position than in the supine position (4.1–4.9% increase, all p
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- 2021
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23. Three-dimensional evaluation of the coccyx movement between supine and standing positions using conventional and upright computed tomography imaging
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Fumiko Yagi, Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Kiyoko Mukai, Takehiro Nakahara, Keiichi Narita, and Masahiro Jinzaki
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Medicine ,Science - Abstract
Abstract Currently, no three-dimensional reference data exist for the normal coccyx in the standing position on computed tomography (CT); however, this information could have utility for evaluating patients with coccydynia and pelvic floor dysfunction. Thus, we aimed to compare coccygeal parameters in the standing versus supine positions using upright and supine CT and evaluate the effects of sex, age, and body mass index (BMI) on coccygeal movement. Thirty-two healthy volunteers underwent both upright (standing position) and conventional (supine position) CT examinations. In the standing position, the coccyx became significantly longer and straighter, with the tip of the coccyx moving backward and downward (all p
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- 2021
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24. Effect of gravity on brain structure as indicated on upright computed tomography
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Yoichi Yokoyama, Yoshitake Yamada, Kenzo Kosugi, Minoru Yamada, Keiichi Narita, Takehiro Nakahara, Hirokazu Fujiwara, Masahiro Toda, and Masahiro Jinzaki
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Medicine ,Science - Abstract
Abstract We aimed to use upright computed tomography (CT) to depict posture-related changes in the brain tissue under normal gravity. Thirty-two asymptomatic volunteers underwent upright CT in the sitting position and conventional CT in the supine position on the same day. We compared the shift of the pineal body, cerebellar tonsil, the length of pituitary stalk, optic nerve sheath area and perimeter (ONSA and ONSP, respectively), and lateral ventricular volume between the supine and sitting positions. We also compared shape changes of the cerebrospinal fluid (CSF) spaces at different sites between both positions. In the sitting position, the pineal body shifted 0.68 ± 0.27 mm in the ventral direction and 0.76 ± 0.24 mm in the caudal direction, the length of pituitary stalk decreased by 1.23 ± 0.71 mm, the cerebellar tonsil descended by 2.10 ± 0.86 mm, the right ONSA decreased by 15.21 ± 6.54%, the left ONSA decreased by 15.30 ± 7.37%, the right ONSP decreased by 8.52 ± 3.91%, the left ONSP decreased by 8.20 ± 4.38%, and the lateral ventricular volume decreased by 5.07 ± 3.24% (all P
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- 2021
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25. Comparison of inspiratory and expiratory lung and lobe volumes among supine, standing, and sitting positions using conventional and upright CT
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Yoshitake Yamada, Minoru Yamada, Shotaro Chubachi, Yoichi Yokoyama, Shiho Matsuoka, Akiko Tanabe, Yuki Niijima, Mitsuru Murata, Koichi Fukunaga, and Masahiro Jinzaki
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Medicine ,Science - Abstract
Abstract Currently, no clinical studies have compared the inspiratory and expiratory volumes of unilateral lung or of each lobe among supine, standing, and sitting positions. In this prospective study, 100 asymptomatic volunteers underwent both low-radiation-dose conventional (supine position, with arms raised) and upright computed tomography (CT) (standing and sitting positions, with arms down) during inspiration and expiration breath-holds and pulmonary function test (PFT) on the same day. We compared the inspiratory/expiratory lung/lobe volumes on CT in the three positions. The inspiratory and expiratory bilateral upper and lower lobe and lung volumes were significantly higher in the standing/sitting positions than in the supine position (5.3–14.7% increases, all P 0.15); the expiratory right middle lobe volume was significantly lower in the standing/sitting positions (16.3/14.1% decrease) than in the supine position (both P
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- 2020
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26. Evaluation of three-dimensional acromiohumeral distance in the standing position and comparison with its conventional measuring methods
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Yuki Yoshida, Noboru Matsumura, Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Morio Matsumoto, Masaya Nakamura, Takeo Nagura, and Masahiro Jinzaki
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Normal shoulder ,Acromiohumeral distance ,Acromiohumeral interval ,Upright computed tomography ,Position ,Digitally reconstructed radiographs ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Narrowing of the acromiohumeral distance (AHD) implies a rotator cuff tear. However, conventional AHD measurements using two-dimensional (2D) imaging or with the patient in the supine position might differ from that while standing during daily activity. This study aimed to evaluate the three-dimensional (3D) actual distance between the acromion and humeral head in the standing position and compare the AHD values with those obtained using conventional measuring methods. Methods Computed tomography (CT) images of 166 shoulders from 83 healthy volunteers (31 male and 52 female; mean age 40.1 ± 5.8 years; age range, 30–49 years) were prospectively acquired in the supine and standing positions using conventional and upright CT scanners, respectively. The minimum distance between the acromion and humeral head on the 3D surface models was considered as the 3D AHD. We measured the 2D AHD on anteroposterior digitally reconstructed radiographs. The AHD values were compared between the supine and standing positions and between the 2D and 3D measurements. Results The mean values of 2D AHD were 8.8 ± 1.3 mm (range, 5.9–15.4 mm) in the standing position and 8.1 ± 1.2 mm (range, 5.3–14.3 mm) in the supine position. The mean values of 3D AHD were 7.3 ± 1.4 mm (range, 4.7–14.0 mm) in the standing position and 6.6 ± 1.2 mm (range, 4.4–13.7 mm) in the supine position. The values of 3D AHD were significantly lower than those of 2D AHDs in both the standing and supine positions (P < 0.001). The values of 2D and 3D AHDs were significantly lower in the supine position than in the standing position (P < 0.001). Conclusions This study evaluated the 3D AHD of normal shoulders in the standing position using an upright CT scanner. The present results indicated that assessments in the supine position can underestimate the value of the AHD compared with those made in the standing position and that assessments using 2D analysis can overestimate the value.
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- 2020
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27. Three-dimensional alignment changes of the shoulder girdle between the supine and standing positions
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Noboru Matsumura, Yoshitake Yamada, Satoshi Oki, Yuki Yoshida, Yoichi Yokoyama, Minoru Yamada, Takeo Nagura, and Masahiro Jinzaki
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Shoulder girdle ,Upright computed tomography ,Shoulder girdle alignment ,Clavicle rotation ,Scapula rotation ,Scapulothoracic joint ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Although humans spend most of their day in a standing or sitting position, it is difficult to accurately evaluate the alignment of the shoulder girdle during daily activity, and its alignment changes between positions. The purpose of this study was to evaluate the 3-dimensional alignment of the shoulder girdle in the supine and standing positions by computed tomography (CT) and to assess the alignment changes of the shoulder girdle between these two positions. Methods CT scans of both shoulders of 100 healthy volunteers were prospectively taken in both supine and standing positions on the same day. The local 3-dimensional coordinate systems of the thorax, clavicle, and scapula were defined from the specific bony landmarks, and 3-dimensional angular rotations and positions of the clavicle and scapula were calculated. Differences in rotations and positions of the clavicle and scapula were evaluated between the supine and standing positions. Results Compared with the supine position, the clavicle showed significantly less elevation and greater retraction, and the scapula showed significantly less upward rotation, anterior tilting, and internal rotation in the standing position. Compared with the supine position, the clavicle center was located more inferiorly, posteriorly, and laterally, and the scapula center was located more inferiorly, posteriorly, and medially in the standing position. Conclusions The present study showed that angular rotations and positions of the clavicle and scapula change significantly with position due to the effect of gravity.
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- 2020
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28. Three-dimensional kinematic change of hindfoot during full weightbearing in standing: an analysis using upright computed tomography and 3D-3D surface registration
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Kazuya Kaneda, Kengo Harato, Satoshi Oki, Tomohiko Ota, Yoshitake Yamada, Minoru Yamada, Morio Matsumoto, Masaya Nakamura, Takeo Nagura, and Masahiro Jinzaki
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Upright computed tomography ,Hindfoot ,Weightbearing ,Surface registration ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Weightbearing of the hindfoot affects positional changes of the ankle joint and subtalar joint (ankle-joint complex [AJC]). However, it is difficult to assess the kinematic changes in the hindfoot in a natural full weightbearing condition using conventional CT or cone beam computed tomography (CT) due to limitations of acquiring foot images under a physiological weightbearing condition using those imaging modalities. Analysis of AJC kinematics using fluoroscopy and 2D-3D registration technique requires data on the number of steps and amount of time to build and match the bones. This study aimed to analyze the effect of full weightbearing on hindfoot motion when standing using upright CT and 3D-3D surface registration. Methods Forty-eight AJCs of 24 asymptomatic volunteers (13 women, 11 men) were examined under no weightbearing, 50% weightbearing, and single leg full weightbearing conditions while standing. The CT images were acquired from the distal femur to the whole foot using a 320-row upright CT scanner. The condition of each weightbearing stance was measured using a pressure mat. Bone-to-bone rotations of the talus relative to the tibia and calcaneus relative to the talus were evaluated using the surface registration technique. Image quality of the CT and intra- and interobserver reliabilities of the rotation angle were also evaluated. Results All CT images were excellent or good quality and the intra- and interobserver correlation coefficients for the angle were 0.996 and 0.995, respectively. The motion of the ankle joint and subtalar joint under 50% and 100% weightbearing were as follows (in degrees); the talus plantarflexed (5.1 ± 4.5 and 6.8 ± 4.8), inverted (1.3 ± 1.4 and 2.0 ± 1.6), and internally rotated (2.4 ± 4.2 and 4.3 ± 4.6) relative to the tibia, and the calcaneus dorsiflexed (2.8 ± 1.4 and 3.8 ± 1.7), everted (5.3 ± 2.6 and 8.0 ± 3.6), and externally rotated (3.0 ± 2.0 and 4.1 ± 2.4) relative to the talus, respectively. Conclusions The effect of weightbearing was clearly identified using an upright CT and the 3D-3D registration technique. Three-dimensional kinematics under static full weightbearing were opposite between the ankle and subtalar joints on their respective axes.
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- 2019
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29. Three-Dimensional Quantitative Evaluation of the Scapular Skin Marker Movements in the Upright Posture
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Yuki Yoshida, Noboru Matsumura, Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Azusa Miyamoto, Masaya Nakamura, Takeo Nagura, and Masahiro Jinzaki
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upright computed tomography ,marker displacement ,soft tissue artifact ,shoulder ,optical motion capture systems ,Chemical technology ,TP1-1185 - Abstract
Motion capture systems using skin markers are widely used to evaluate scapular kinematics. However, soft-tissue artifact (STA) is a major limitation, and there is insufficient knowledge of the marker movements from the original locations. This study explores a scapular STA, including marker movements with shoulder elevation using upright computed tomography (CT). Ten healthy males (twenty shoulders in total) had markers attached to scapular bony landmarks and underwent upright CT in the reference and elevated positions. Marker movements were calculated and compared between markers. The bone-based and marker-based scapulothoracic rotation angles were also compared in both positions. The median marker movement distances were 30.4 mm for the acromial angle, 53.1 mm for the root of the scapular spine, and 70.0 mm for the inferior angle. Marker movements were significantly smaller on the superolateral aspect of the scapula, and superior movement was largest in the directional movement. Scapulothoracic rotation angles were significantly smaller in the marker-based rotation angles than in the bone-based rotation angles of the elevated position. We noted that the markers especially did not track the inferior movement of the scapular motion with shoulder elevation, resulting in an underestimation of the marker-based rotation angles.
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- 2022
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30. Impact of the cerebrospinal fluid-mask algorithm on the diagnostic performance of 123I-Ioflupane SPECT: an investigation of parkinsonian syndromes
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Yu Iwabuchi, Tadaki Nakahara, Masashi Kameyama, Yohji Matsusaka, Yasuhiro Minami, Daisuke Ito, Hajime Tabuchi, Yoshitake Yamada, and Masahiro Jinzaki
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123I-Ioflupane ,123I-FP-CIT ,DAT SPECT ,Southampton method ,Specific binding ratio ,CSF-mask ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background A cerebrospinal fluid (CSF)-mask algorithm has been developed to reduce the adverse influence of CSF-low-counts on the diagnostic utility of the specific binding ratio (SBR) index calculated with Southampton method. We assessed the effect of the CSF-mask algorithm on the diagnostic performance of the SBR index for parkinsonian syndromes (PS), including Parkinson’s disease, and the influence of cerebral ventricle dilatation on the CSF-mask algorithm. Methods We enrolled 163 and 158 patients with and without PS, respectively. Both the conventional SBR (non-CSF-mask) and SBR corrected with the CSF-mask algorithm (CSF-mask) were calculated from 123I-Ioflupane single-photon emission computed tomography (SPECT) images of these patients. We compared the diagnostic performance of the corresponding indices and evaluated whether the effect of the CSF-mask algorithm varied according to the extent of ventricle dilatation, as assessed with the Evans index (EI). A receiver-operating characteristics (ROC) analysis was used for statistical analyses. Results ROC analyses demonstrated that the CSF-mask algorithm performed better than the non-CSF-mask (no correction, area under the curve [AUC] = 0.917 [95% confidence interval (CI) 0.887–0.947] vs. 0.895 [95% CI 0.861–0.929], p
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- 2019
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31. Postnatal ultrasonography for evaluation of hernia sac of neonate with congenital diaphragmatic hernia
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Takahiro Hosokawa, MD, Yutaka Tanami, MD, Yumiko Sato, MD, Eiji Oguma, MD, Kanako Omata, MD, Hiroshi Kawashima, MD, and Yoshitake Yamada, MD
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Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Congenital diaphragmatic hernia (CDH) is one of the most common major congenital anomalies. The presence of a hernia sac is associated with additional benefits in terms of improved neonatal survival. Here, we report a case of CDH with a hernia sac detected via postnatal ultrasonography. Our literature search did not find other cases where CDH with hernia sac was found by postnatal ultrasound in neonates. In prenatal imaging, the diagnosis of CDH with a hernia sac is challenging. In our case, the meniscus of the thymus was clearly noted, and smooth convexity between the hernia contents and thymus was detected. Although evaluation of the presence of a hernia sac with postnatal ultrasonography might be difficult, our findings suggest that a hernia sac could be evaluated with postnatal ultrasonography. Keywords: Congenital diaphragmatic hernia, Hernia sac, Ultrasonography, Bochdalek hernia
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- 2019
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32. Impact of a combination of quantitative indices representing uptake intensity, shape, and asymmetry in DAT SPECT using machine learning: comparison of different volume of interest settings
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Yu Iwabuchi, Tadaki Nakahara, Masashi Kameyama, Yoshitake Yamada, Masahiro Hashimoto, Yohji Matsusaka, Takashi Osada, Daisuke Ito, Hajime Tabuchi, and Masahiro Jinzaki
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123I-Ioflupane ,123I-FP-CIT ,DAT SPECT ,Parkinson’s syndrome ,Support vector machine ,Machine learning ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background We sought to assess the machine learning-based combined diagnostic accuracy of three types of quantitative indices obtained using dopamine transporter single-photon emission computed tomography (DAT SPECT)—specific binding ratio (SBR), putamen-to-caudate ratio (PCR)/fractal dimension (FD), and asymmetry index (AI)—for parkinsonian syndrome (PS). We also aimed to compare the effect of two different types of volume of interest (VOI) settings from commercially available software packages DaTQUANT (Q) and DaTView (V) on diagnostic accuracy. Methods Seventy-one patients with PS and 40 without PS (NPS) were enrolled. Using SPECT images obtained from these patients, three quantitative indices were calculated at two different VOI settings each. SBR-Q, PCR-Q, and AI-Q were derived using the VOI settings from DaTQUANT, whereas SBR-V, FD-V, and AI-V were derived using those from DaTView. We compared the diagnostic value of these six indices for PS. We incorporated a support vector machine (SVM) classifier for assessing the combined accuracy of the three indices (SVM-Q: combination of SBR-Q, PCR-Q, and AI-Q; SVM-V: combination of SBR-V, FD-V, and AI-V). A Mann-Whitney U test and receiver-operating characteristics (ROC) analysis were used for statistical analyses. Results ROC analyses demonstrated that the areas under the curve (AUC) for SBR-Q, PCR-Q, AI-Q, SBR-V, FD-V, and AI-V were 0.978, 0.837, 0.802, 0.906, 0.972, and 0.829, respectively. On comparing the corresponding quantitative indices between the two types of VOI settings, SBR-Q performed better than SBR-V (p = 0.006), whereas FD-V performed better than PCR-Q (p = 0.0003). No significant difference was observed between AI-Q and AI-V (p = 0.56). The AUCs for SVM-Q and SVM-V were 0.988 and 0.994, respectively; the two different VOI settings displayed no significant differences in terms of diagnostic accuracy (p = 0.48). Conclusion The combination of the three indices obtained using the SVM classifier improved the diagnostic performance for PS; this performance did not differ based on the VOI settings and software used.
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- 2019
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33. Progression of traction bronchiectasis/bronchiolectasis in interstitial lung abnormalities is associated with increased all-cause mortality: Age Gene/Environment Susceptibility-Reykjavik Study
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Takuya Hino, Tomoyuki Hida, Mizuki Nishino, Junwei Lu, Rachel K. Putman, Elias F. Gudmundsson, Akinori Hata, Tetsuro Araki, Vladimir I. Valtchinov, Osamu Honda, Masahiro Yanagawa, Yoshitake Yamada, Takeshi Kamitani, Masahiro Jinzaki, Noriyuki Tomiyama, Kousei Ishigami, Hiroshi Honda, Raul San Jose Estepar, George R. Washko, Takeshi Johkoh, David C. Christiani, David A. Lynch, Vilmundur Gudnason, Gunnar Gudmundsson, Gary M. Hunninghake, and Hiroto Hatabu
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Interstitial lung abnormality ,Usual interstitial pneumonia ,Pulmonary fibrosis ,Traction bronchiectasis ,Age Gene/Environment Susceptibility-Reykjavik Study ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Purpose: The aim of this study is to assess the role of traction bronchiectasis/bronchiolectasis and its progression as a predictor for early fibrosis in interstitial lung abnormalities (ILA). Methods: Three hundred twenty-seven ILA participants out of 5764 in the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study who had undergone chest CT twice with an interval of approximately five-years were enrolled in this study. Traction bronchiectasis/bronchiolectasis index (TBI) was classified on a four-point scale: 0, ILA without traction bronchiectasis/bronchiolectasis; 1, ILA with bronchiolectasis but without bronchiectasis or architectural distortion; 2, ILA with mild to moderate traction bronchiectasis; 3, ILA and severe traction bronchiectasis and/or honeycombing. Traction bronchiectasis (TB) progression was classified on a five-point scale: 1, Improved; 2, Probably improved; 3, No change; 4, Probably progressed; 5, Progressed. Overall survival (OS) among participants with different TB Progression Score and between the TB progression group and No TB progression group was also investigated. Hazard radio (HR) was estimated with Cox proportional hazards model. Results: The higher the TBI at baseline, the higher TB Progression Score (P
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- 2021
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34. Peripheral pulmonary stenosis with Noonan syndrome treated by balloon pulmonary angioplasty
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Seien Ko, Jin Komuro, Yoshinori Katsumata, Yasuyuki Shiraishi, Takashi Kawakami, Yoshitake Yamada, Shinsuke Yuasa, Takashi Kohno, Kenjiro Kosaki, and Keiichi Fukuda
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Diseases of the respiratory system ,RC705-779 - Abstract
Noonan syndrome is known to have various cardiovascular defects, which include pulmonary artery stenosis. Pulmonary artery stenosis is characterized by obstruction of pulmonary artery blood flow that can cause elevated pulmonary artery pressure and ventilation-perfusion inequality, which can cause dyspnea on exertion and eventually, heart failure. Although the etiology of pulmonary artery stenosis related to congenital diseases is still unknown, balloon pulmonary angioplasty has being reported to be effective to selected patients with Alagille and Williams syndromes, but not from Noonan syndrome despite of modest prevalence of pulmonary artery stenosis. Here, we report the first Noonan syndrome patient with pulmonary artery stenosis who underwent successful balloon pulmonary angioplasty. The strategy used in balloon pulmonary angioplasty was planned with careful morphologic evaluation by computed tomographic angiography, and performed with scoring balloons in a graded approach with multiple sessions. After balloon pulmonary angioplasty, we confirmed maintained dilation of lesions and symptom alleviation, suggesting that balloon pulmonary angioplasty can be performed safely on pulmonary artery stenosis in a Noonan syndrome patient.
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- 2020
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35. Successful depiction of systemic collateral supply to pulmonary artery in CTEPH using time-resolved 4D CT angiography: a case report
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Masashi Tamura, Takashi Kawakami, Yoshitake Yamada, Masaharu Kataoka, Seishi Nakatsuka, Keiichi Fukuda, and Masahiro Jinzaki
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Diseases of the respiratory system ,RC705-779 - Abstract
A 49-year-old man with CTEPH (pre-procedural mean pulmonary artery pressure: 36 mmHg) underwent balloon pulmonary angioplasty. Chronic total occlusion of the left inferior pulmonary artery trunk was observed. To evaluate the collateral vessels of the chronic total occlusion, 4D-CTA was performed. The examination was performed using a 256-row detector CT system using the test bolus tracking method. 4D-CTA showed the bronchial artery-to-left inferior pulmonary artery collateral supply, which was confirmed by a selective bronchial artery angiography. The patient’s symptoms improved with balloon pulmonary angioplasty of the other stenotic lesions. 4D-CTA can noninvasively evaluate the anatomy and hemodynamics of multiple systemic collaterals simultaneously. This technique can support interventions in systemic artery-to-pulmonary artery collaterals, such as embolization, and could be helpful in challenging balloon pulmonary angioplasty interventions for chronic total occlusion to identify vessel structures distal to the chronic total occlusion and collateral channels for a retrograde approach.
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- 2020
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36. Projected lung areas using dynamic X-ray (DXR)
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Takuya Hino, Akinori Hata, Tomoyuki Hida, Yoshitake Yamada, Masako Ueyama, Tetsuro Araki, Takeshi Kamitani, Mizuki Nishino, Atsuko Kurosaki, Masahiro Jinzaki, Kousei Ishigami, Hiroshi Honda, Hiroto Hatabu, and Shoji Kudoh
- Subjects
dynamic X-ray ,Chest radiograph ,Pulmonary function ,Health screening cohort ,Projected lung area ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Background: Dynamic X-ray (DXR) provides images of multiple phases of breath with less radiation exposure than CT. The exact images at end-inspiratory or end-expiratory phases can be chosen accurately. Purpose: To investigate the correlation of the projected lung area (PLA) by dynamic chest X-ray with pulmonary functions. Material and Methods: One hundred sixty-two healthy volunteers who received medical check-ups for health screening were included in this study. All subjects underwent DXR in both posteroanterior (PA) and lateral views and pulmonary function tests on the same day. All the volunteers took several tidal breaths before one forced breath as instructed. The outlines of lungs were contoured manually on the workstation with reference to the motion of diaphragm and the graph of pixel values. The PLAs were calculated automatically, and correlations with pulmonary functions and demographic data were analyzed statistically. Results: The PLAs have correlation with physical characteristics, including height, weight and BMI, and pulmonary functions such as vital capacity (VC) and forced expiratory volume in one second (FEV1). VC and FEV1 revealed moderate correlation with the PLAs of PA view in forced inspiratory phase (VC: right, r = 0.65; left, r = 0.69. FEV1: right, r = 0.54; left, r = 0.59). Multivariate analysis showed that body mass index (BMI), sex and VC were considered independent correlation factors, respectively. Conclusion: PLA showed statistically significant correlation with pulmonary functions. Our results indicate DXR has a possibility to serve as an alternate method for pulmonary function tests in subjects requiring contact inhibition including patients with suspected or confirmed covid-19.
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- 2020
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37. Congenital dermoid fistulas of the anterior chest region (CDFACR): usefulness of sonography for complete resection
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Takahiro Hosokawa, MD, Yoshitake Yamada, MD, Hiroaki Takahashi, MD, Yumiko Sato, MD, Yutaka Tanami, MD, Keisuke Suzuki, MD, Hiroshi Kawashima, MD, and Eiji Oguma, MD
- Subjects
Dermoid cyst ,Sternoclavicular joint ,Branchial cleft cyst ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Congenital dermoid fistulas of the anterior chest regions (CDFACRs) consist of a skin orifice at the anterior border of the sternocleidomastoid muscle with fistulas extending caudally in the subcutaneous tissue near the sternoclavicular joint. We report 2 pediatric CDFACR cases with pathognomonic sonography findings. By using sonography, we could diagnose the fistulas as CDFACRs by focusing on their location and direction and could reveal the distal side for complete resection. We suggest that sonography, which does not involve radiation or require sedation, is a better choice for the initial examination of CDFACRs than computed tomography or MRI.
- Published
- 2017
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38. The efficacy, safety, and feasibility of inhaled amikacin for the treatment of difficult-to-treat non-tuberculous mycobacterial lung diseases
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Kazuma Yagi, Makoto Ishii, Ho Namkoong, Takahiro Asami, Osamu Iketani, Takanori Asakura, Shoji Suzuki, Hiroaki Sugiura, Yoshitake Yamada, Tomoyasu Nishimura, Hiroshi Fujiwara, Yohei Funatsu, Yoshifumi Uwamino, Tetsuro Kamo, Sadatomo Tasaka, Tomoko Betsuyaku, and Naoki Hasegawa
- Subjects
Non-tuberculous mycobacterial lung diseases ,Inhaled amikacin therapy ,Clarithromycin resistance ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background In multidrug regimens, including an intravenous aminoglycoside (e.g. amikacin [AMK]) is recommended for difficult-to-treat non-tuberculous mycobacterial (NTM) lung diseases. We aimed to evaluate the efficacy, safety, and feasibility of inhaled AMK therapy in patients with difficult-to-treat NTM lung diseases in a retrospective chart review. Methods The study population consisted of patients with NTM lung diseases who received combination therapy, including inhaled AMK therapy, at Keio University Hospital (Tokyo, Japan), from January 2014 through May 2016. A total of 26 cases, consisting of 23 Mycobacterium avium complex (MAC) and three Mycobacterium abscessus complex (MABC) infections cases, were included in this study. The efficacy, safety, and feasibility of inhaled AMK therapy were retrospectively investigated. The Research Ethics Committee of Keio University Hospital approved this study, and informed consent was obtained from all patients. Results All 26 patients were culture-positive at enrolment. Twenty-three of the 26 patients (88.5%), including 21/23 MAC patients (91.3%) and 2/3 MABC patients (66.7%), were administered inhaled AMK therapy for >3 months. The proportion of patients who had clinical symptoms, including, cough and sputum, declined after inhalation AMK therapy. Ten of the 23 patients (43.5%) who received AMK inhalation, including 8/21 MAC (38.1%) and 2/2 MABC patients (100%), showed sputum conversion, defined as at least three consecutive negative sputum cultures. Seven of the 23 patients, including, 5/21 MAC and 2/2 MABC patients, showed improvements in high-resolution computed tomography imaging of the chest. In addition, the serum AMK trough levels before the second inhalation were
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- 2017
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39. Three-dimensional joint surface orientation does not correlate with two-dimensional coronal joint line orientation in knee osteoarthritis: Three-dimensional analysis of upright computed tomography
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Ryo Sasaki, Yasuo Niki, Kazuya Kaneda, Yoshitake Yamada, Takeo Nagura, Masaya Nakamura, and Masahiro Jinzaki
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Orthopedics and Sports Medicine - Published
- 2023
40. Traction Bronchiectasis/Bronchiolectasis on CT Scans in Relationship to Clinical Outcomes and Mortality: The COPDGene Study
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Akinori, Hata, Takuya, Hino, Rachel K, Putman, Masahiro, Yanagawa, Tomoyuki, Hida, Aravind A, Menon, Osamu, Honda, Yoshitake, Yamada, Mizuki, Nishino, Tetsuro, Araki, Vladimir I, Valtchinov, Masahiro, Jinzaki, Hiroshi, Honda, Kousei, Ishigami, Takeshi, Johkoh, Noriyuki, Tomiyama, David C, Christiani, David A, Lynch, Raúl, San José Estépar, George R, Washko, Michael H, Cho, Edwin K, Silverman, Gary M, Hunninghake, and Hiroto, Hatabu
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Lung Diseases ,Male ,Traction ,Quality of Life ,Humans ,Radiology, Nuclear Medicine and imaging ,Middle Aged ,Tomography, X-Ray Computed ,Bronchiectasis - Abstract
Background The clinical impact of interstitial lung abnormalities (ILAs) on poor prognosis has been reported in many studies, but risk stratification in ILA will contribute to clinical practice. Purpose To investigate the association of traction bronchiectasis/bronchiolectasis index (TBI) with mortality and clinical outcomes in individuals with ILA by using the COPDGene cohort. Materials and Methods This study was a secondary analysis of prospectively collected data. Chest CT scans of participants with ILA for traction bronchiectasis/bronchiolectasis were evaluated and outcomes were compared with participants without ILA from the COPDGene study (January 2008 to June 2011). TBI was classified as follows: TBI-0, ILA without traction bronchiectasis/bronchiolectasis; TBI-1, ILA with bronchiolectasis but without bronchiectasis or architectural distortion; TBI-2, ILA with mild to moderate traction bronchiectasis; and TBI-3, ILA with severe traction bronchiectasis and/or honeycombing. Clinical outcomes and overall survival were compared among the TBI groups and the non-ILA group by using multivariable linear regression model and Cox proportional hazards model, respectively. Results Overall, 5295 participants (median age, 59 years; IQR, 52-66 years; 2779 men) were included, and 582 participants with ILA and 4713 participants without ILA were identified. TBI groups were associated with poorer clinical outcomes such as quality of life scores in the multivariable linear regression model (TBI-0: coefficient, 3.2 [95% CI: 0.6, 5.7
- Published
- 2023
41. Balloon pulmonary angioplasty versus riociguat in inoperable chronic thromboembolic pulmonary hypertension (MR BPA): an open-label, randomised controlled trial
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Takashi Kawakami, Hiromi Matsubara, Toshiro Shinke, Kohtaro Abe, Shun Kohsaka, Kazuya Hosokawa, Yu Taniguchi, Hiroto Shimokawahara, Yoshitake Yamada, Masaharu Kataoka, Aiko Ogawa, Mitsushige Murata, Masahiro Jinzaki, Kenichi Hirata, Hiroyuki Tsutsui, Yasunori Sato, and Keiichi Fukuda
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Pulmonary and Respiratory Medicine - Published
- 2022
42. Effect of Ultra-High-Resolution CT on Pseudoenhancement in Renal Cysts: A Phantom Experiment and Clinical Study
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Fumiko, Hamabe, Ayako, Mikoshi, Hiromi, Edo, Hiroaki, Sugiura, Kousuke, Okano, Yoshitake, Yamada, Masahiro, Jinzaki, and Hiroshi, Shinmoto
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Aged, 80 and over ,Male ,Cysts ,Phantoms, Imaging ,Humans ,Female ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Kidney Diseases, Cystic ,Tomography, X-Ray Computed ,Aged ,Retrospective Studies - Published
- 2022
43. Post-Traumatic Pulmonary Hematoma Presenting as Multiple Ring-shaped Spherical Nodules.
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Orito Ikeda, Kunihiko Shimizu, Yoshitake Yamada, Hiroaki Sugiura, Miki Takahashi, Tokuhiro Kimura, Hideaki Suzuki, Kozo Sato, and Masahiro Jinzaki
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POSITRON emission tomography computed tomography ,HEMATOMA - Abstract
The article presents a case study of a 15-year-old girl who presented with severe chest and back pain after a high-energy motorcycle accident, revealing multiple ring-shaped spherical nodules in both lungs on contrast-enhanced computed tomography. Topics include the clinical presentation of post-traumatic pulmonary hematoma, the radiological findings of ring-shaped nodules, and the use of positron emission tomography–CT for diagnosis in challenging cases.
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- 2023
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44. Accuracy of ultra-high–resolution computed tomography with a 0.3-mm detector for quantitative assessment of coronary artery stenosis grading in comparison with conventional computed tomography: A phantom study
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Minoru Yamada, Sachio Kuribayashi, Takehiro Nakahara, Takayuki Abe, Yoshitake Yamada, Masahiro Jinzaki, and Shigeo Okuda
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medicine.diagnostic_test ,Phantoms, Imaging ,business.industry ,Detector ,Coronary Stenosis ,Computed tomography ,Constriction, Pathologic ,Coronary stenosis ,Coronary Angiography ,Ultra high resolution ,Imaging phantom ,Predictive Value of Tests ,Quantitative assessment ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Grading (tumors) - Abstract
The development of ultra-high-resolution CT (U-HRCT) is expected to improve the accuracy of coronary stenosis evaluation. This study aimed to evaluate the accuracy of the stenosis severities of coronary artery phantoms estimated using U-HRCT by comparing them to those estimated with conventional CT.Coronary artery phantoms with non-calcified and calcified lesions were scanned with conventional CT (64-row × 0.625 mm) and U-HRCT (32-row × 0.3125 mm). The coronary artery phantoms had lumen diameters of 2.0, 3.0, and 4.0 mm with non-calcified lesions representing 0%, 25%, 50%, and 75% stenosis and 3.0 and 4.0 mm with calcified lesions representing 0%, 25%, 50%, and 75% stenosis. The lumen diameters at the stenotic and non-stenotic regions were measured, and the stenosis severities were compared with the true values.For non-calcified lesions, conventional CT significantly underestimated the stenosis severity in the phantom showing 75% stenosis with lumen diameters of 2.0 and 3.0 mm (p 0.05), while the estimated stenosis severities were not significantly different from the true values at all settings with U-HRCT. For the calcified lesions, conventional CT overestimated the stenosis severities at all settings (p 0.05), while U-HRCT yielded estimations closer to the true values, although still with some overestimation (p 0.05).By using U-HRCT, the estimated stenosis severities of the coronary artery with non-calcified lesion become almost equal to the true value, while those with calcified lesion are still overestimated although they become closer to the true value.
- Published
- 2022
45. Three‐dimensional shoulder kinematics: Upright four‐dimensional computed tomography in comparison with an optical three‐dimensional motion capture system
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Yuki Yoshida, Noboru Matsumura, Azusa Miyamoto, Satoshi Oki, Yoichi Yokoyama, Minoru Yamada, Yoshitake Yamada, Masaya Nakamura, Takeo Nagura, and Masahiro Jinzaki
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Orthopedics and Sports Medicine - Abstract
Although shoulder kinematics have been analyzed by various methods, dynamic shoulder motion is difficult to track. This study aimed to validate the shoulder kinematic analysis using upright four-dimensional computed tomography (4DCT) and to compare the results with optical three-dimensional motion capture. During active elevation, bilateral shoulders of 10 healthy volunteers were tracked using 4DCT and motion capture. The scapulothoracic and glenohumeral rotations and the scapulohumeral rhythm (SHR) at each position were calculated, and the differences between 4DCT and motion capture were compared. During 10-140° of humerothoracic elevation, the scapulothoracic joint showed upward rotation, internal rotation, and posterior tilting, and the glenohumeral joint showed elevation, external rotation, and anterior plane of elevation in both analyses. In scapulothoracic rotations, the mean differences between the two analyses were -2.6° in upward rotation, 13.9° in internal rotation, and 6.4° in posterior tilting, and became significant with humerothoracic elevation ≥110° in upward rotation, ≥50° in internal rotation, and ≥100° in posterior tilting. In glenohumeral rotations, the mean differences were 3.7° in elevation, 9.1° in internal rotation, and -8.8° in anterior plane of elevation, and became significant with humerothoracic elevation ≥110° in elevation, ≥90° in internal rotation, and ≥100° in anterior plane of elevation. The mean overall SHRs were 1.8 in 4DCT and 2.4 in motion capture, and the differences became significant with humerothoracic elevation ≥100°. The 4DCT analysis of in vivo shoulder kinematics using upright computed tomography scanner is feasible, but the values were different from those by skin-based analysis at the elevated arm positions.
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- 2022
46. Outcomes of the Nuss procedure for pectus excavatum in adults
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Masahiro Jinzaki, Kazuo Kishi, Tomohisa Nagasao, Yoichi Yokoyama, Minoru Yamada, Yoshiaki Sakamoto, and Yoshitake Yamada
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Adult ,Male ,Thorax ,medicine.medical_specialty ,Supine position ,Thoracic spine ,Computed tomography ,030204 cardiovascular system & hematology ,Nuss procedure ,03 medical and health sciences ,0302 clinical medicine ,Pectus excavatum ,medicine ,Humans ,Lung volumes ,Funnel Chest ,medicine.diagnostic_test ,business.industry ,Thoracic Surgical Procedures ,medicine.disease ,Surgery ,030228 respiratory system ,Female ,Tomography, X-Ray Computed ,business - Abstract
Limited data exist with regard to the outcome of the Nuss procedure for pectus excavatum repair in adults. Here, we analysed changes in lung capacity and thoracic morphology based on computed tomography (CT) imaging in adults with pectus excavatum before surgery, during bar insertion and after bar removal. Patients who underwent the Nuss procedure for pectus excavatum after the age of 20 were included in this study. Chest CT scans of the included participants were taken before the Nuss procedure, immediately before removal of the pectus bar and 6 months after removal of the pectus bar. Lung capacity and thoracic morphology measurements were made from the CT scans. Six patients aged 24-43 years were included in this study. After the Nuss procedure, lung capacity was decreased in all patients. Although the pectus bar was removed, lung capacity had not significantly increased and was almost the same volume as before the Nuss procedure. After the Nuss procedure, the funnel chest shape had improved in all cases, patients' thoracic spine had also moved forward as the thorax moved forward and patients' stoop had improved. Despite a lack of change in lung capacity, surgical modification should be considered to reduce stress on the thoracic spine and in turn, reduce pain in patients with pectus excavatum. However, further long-term observation seems necessary.
- Published
- 2021
47. Changes in the lumbar intervertebral foramen between supine and standing posture in patients with adult spinal deformity: a study with upright computed tomography
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Naruhito Fujita, Mitsuru Yagi, Yoshitake Yamada, Yoichi Yokoyama, Minoru Yamada, Kota Watanabe, Masaya Nakamura, Takeo Nagura, and Masahiro Jinzaki
- Subjects
Radiology, Nuclear Medicine and imaging - Abstract
To quantitatively assess the impact of supine and standing positions on the morphological changes in the lumbar intervertebral foramen (LIF) in patients with adult spinal deformity (ASD) using upright CT and conventional supine CT.Thirty patients with ASD were prospectively enrolled in this study. All subjects underwent standing whole spine posterior/anterior radiographs, lateral radiographs, and whole spine CT, both in the supine and upright standing positions. Two orthopedic surgeons independently measured nine radiographic parameters in the radiograph and the lumbar foraminal area (FA) and height (FH) in supine and upright CT. Statistical analyses were performed to evaluate the risk of LIF decrease when standing upright compared to the supine position. The chi-squared, t test, Pearson's coefficients, intra- and inter-rater reliabilities, and ROC curves were calculated. The level of significance was set at p 0.05.Among the 300 LIFs, both the lumbar FA and FH were either increased or decreased by 5% in approximately 30% of LIFs each. The FA decreased in the lower lumbar spine. The concave side had a significantly higher rate of decreased FA and FH than the convex side (p 0.05 and 0.05, respectively). ROC analysis showed that narrowing of the intervertebral disc (cutoff 0.05°) is a risk factor for decreased FA and FH.This study describes the details of the changes in the neuroforamen using a novel upright CT. In patients with ASD, approximately 30% of LIFs either increased or decreased in size by 5% when standing. The risk factors for LIF decrease are the lower lumbar spine, concave side, and narrow side of the disc wedge.
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- 2022
48. Saphenous vein valve assessment utilizing upright CT to potentially improve graft assessment for bypass surgery
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Yoshitake Yamada, Takehiro Nakahara, Hideyuki Shimizu, Yoichi Yokoyama, Masahiro Jinzaki, Minoru Yamada, Jagat Narula, Nobuaki Imanishi, Keiichi Narita, and Masataka Yamazaki
- Subjects
Adult ,Male ,medicine.medical_specialty ,Supine position ,Graft failure ,Science ,Cardiology ,Computed tomography ,030204 cardiovascular system & hematology ,Article ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Cadaver ,Healthy volunteers ,Supine Position ,medicine ,Humans ,Saphenous Vein ,Tomography ,Aged ,Aged, 80 and over ,Leg ,Multidisciplinary ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Healthy Volunteers ,Surgery ,Radiography ,Bypass surgery ,Standing Position ,Medicine ,Female ,Vascular Grafting ,Venous Valves ,Medical imaging ,Vein valve ,Tomography, X-Ray Computed ,business ,Saphenous veins - Abstract
Saphenous veins (SVs) are frequently employed as bypass grafts. The SV graft failure is predominantly seen at the valve site. Avoiding valves during vein harvest would help reduce graft failure. We endeavored to detect SV valves, tributaries, and vessel size employing upright computed tomography (CT) for the raw cadaver venous samples and in healthy volunteers. Five cadaver legs were scanned. Anatomical analysis showed 3.0 (IQR: 2.0–3.0) valves and 13.50 (IQR: 10.00–16.25) tributaries. The upright CT completely detected, compared to 2.0 (IQR: 1.5–2.5, p = 0.06) valves and 9.5 (IQR: 7.5–13.0, p = 0.13) tributaries by supine CT. From a total of 190 volunteers, 138 (men:75, women:63) were included. The number of valves from the SF junction to 35 cm were significantly higher in upright CT than in supine CT bilaterally [upright vs. supine, Right: 4 (IQR: 3–5) vs. 2 (IQR:1–2), p p
- Published
- 2021
49. Anatomic and diagnostic considerations of facial mobility for understanding the effectiveness of facial massage: A pilot study
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Keiichi Akita, Masahiro Jinzaki, Itsuko Okuda, Natnicha Kampan, Yoshitake Yamada, Minoru Yamada, and Yoichi Yokoyama
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Adult ,Massage ,Orthodontics ,Supine position ,medicine.diagnostic_test ,business.industry ,Pilot Projects ,Computed tomography ,Dermatology ,Lymphatic flow ,01 natural sciences ,010309 optics ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Face ,Face (geometry) ,0103 physical sciences ,Humans ,Medicine ,Tomography, X-Ray Computed ,Cadaveric spasm ,business ,Facial massage - Abstract
Background The effectiveness of facial massage is often explained by the resulting increases in the blood and lymphatic flow. However, it is difficult to explain the lifting effect on the cheeks. The aim of this study was to analyze facial mobility to further current understanding of the effectiveness of facial massage. Materials and methods Two kinds of analytical methods were designed using a cadaveric head as well as advanced computed tomography (CT). The cadaveric face was divided into three sections, and three different colors of ink were injected into each section. It was kept in a supine position for 24 hours, and the ink distribution was observed. Upright and supine CT examinations were performed on six healthy adult volunteers. The images of both were superimposed by a three-dimensional image analysis system, and changes in facial contours were analyzed. Results The three colors of ink spread craniocaudally and were distributed differently from the gravitational vector. When both CT images were superimposed, two distinct lines were formed, which represented overlapping of the facial contours due to the two different CT images. These lines were found to correspond to the border of each color of the ink. Conclusion Focusing on the mobility of the face, the soft tissue of the face had vertical mobility, and it was speculated that this mobility is involved in the effectiveness of facial massage. Our results could provide useful information for cosmetic treatment and contribute to the collection of scientific knowledge for anti-aging medicine.
- Published
- 2021
50. Comparison of Lung, Lobe, and Airway Volumes between Supine and Upright Computed Tomography and Their Correlation with Pulmonary Function Test in Patients with Chronic Obstructive Pulmonary Disease
- Author
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Yoshitake Yamada, Shotaro Chubachi, Minoru Yamada, Yoichi Yokoyama, Akiko Tanabe, Shiho Matsuoka, Yuki Niijima, Mitsuru Murata, Koichi Fukunaga, and Masahiro Jinzaki
- Subjects
Pulmonary and Respiratory Medicine ,Pulmonary Disease, Chronic Obstructive ,Standing Position ,Humans ,Tomography, X-Ray Computed ,Lung ,Respiratory Function Tests - Abstract
Background: Correlations between upright CT and pulmonary function test (PFT) measurements, and differences in lung/lobe/airway volumes between supine and standing positions in patients with chronic obstructive pulmonary disease (COPD) remain unknown. Objectives: The study aimed to evaluate correlations between lung/airway volumes on both supine and upright CT and PFT measurements in patients with COPD, and compare CT-based inspiratory/expiratory lung/lobe/airway volumes between the two positions. Methods: Forty-eight patients with COPD underwent both conventional supine and upright CT in a randomized order during inspiration and expiration breath-holds, and PFTs within 2 h. We measured the lung/lobe/airway volumes on both CT. Results: The correlation coefficients between total lung volumes on inspiratory CT in supine/standing position and PFT total lung capacity and vital capacity were 0.887/0.920 and 0.711/0.781, respectively; between total lung volumes on expiratory CT in supine/standing position and PFT functional residual capacity and residual volume, 0.676/0.744 and 0.713/0.739, respectively; and between airway volume on inspiratory CT in supine/standing position and PFT forced expiratory volume in 1 s, 0.471/0.524, respectively. Inspiratory/expiratory bilateral upper and right lower lobe, bilateral lung, and airway volumes were significantly higher in the standing than supine position (3.6–21.2% increases, all p < 0.05); however, inspiratory/expiratory right middle lobe volumes were significantly lower in the standing position (4.6%/15.9% decreases, respectively, both p < 0.001). Conclusions: Upright CT-based volumes were more correlated with PFT measurements than supine CT-based volumes in patients with COPD. Unlike other lobes and airway, inspiratory/expiratory right middle lobe volumes were significantly lower in the standing than supine position.
- Published
- 2022
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