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A counter-propagating laser-beam platform using a spherical plasma mirror was developed for the kilojoule-class petawatt LFEX laser. The temporal and spatial overlaps of the incoming and redirected beams were measured with an optical interferometer and an x-ray pinhole camera. The plasma mirror performance was evaluated by measuring fast electrons, ions, and neutrons generated in the counter-propagating laser interaction with a Cu-doped deuterated film on both sides. The reflectivity and peak intensity were estimated as ∼50% and ∼5 × 1018 W/cm2, respectively. The platform could enable studies of counter-streaming charged particles in high-energy-density plasmas for fundamental and inertial confinement fusion research.

Aims/Introduction The role of glucagon abnormality has recently been reported in type 2 diabetes; however, its role in gestational diabetes mellitus (GDM) is still unknown. The glucose intolerance in GDM is heterogeneous, and not all patients require insulin treatment during pregnancy. Here, we investigated whether glucagon abnormality is associated with the requirement for insulin treatment during pregnancy. Materials and Methods A total of 49 pregnant women diagnosed with GDM were enrolled. They underwent a 75‐g oral glucose tolerance test during mid‐gestation, and we measured their plasma glucagon levels (by a new sandwich enzyme‐linked immunosorbent assay) at fasting (0 min), and at 30, 60 and 120 min after glucose load in addition to the levels of plasma glucose and serum insulin. All participants underwent another oral glucose tolerance test at postpartum. Results Of the 49 patients, 15 required insulin treatment (Insulin group) and 34 were treated with diet therapy alone until delivery (Diet group). The early‐phase glucagon secretion after glucose load, as determined by the changes in glucagon from the baseline to 30 min, was paradoxically augmented during mid‐gestation in the Insulin group, but not in the Diet group. The impaired glucagon suppression during mid‐gestation in the Insulin group was not associated with insulin secretory/sensitivity indexes studied, and was ameliorated postpartum, although the plasma glucose levels remained higher in the Insulin group versus the Diet group. Conclusions Impaired early‐phase suppression of glucagon could be associated with the requirement for insulin treatment during pregnancy in patients with GDM., We evaluated the glucagon responses to oral glucose load in patients with gestational diabetes mellitus using a new sandwich enzyme‐linked immunosorbent assay. We investigated whether the glucagon abnormality is associated with the requirement for insulin treatment during pregnancy.

Differences in cultural consumption are well recognized as potential forces for changing the cultural identity of consumers. Based on this logic, our hypothesis posits that Chinese readers, who comprise the largest fan community of Japanese comics/anime, are culturally influenced by this foreign product. To examine this hypothesis, we question whether the global values and worldviews of freedom, peaceful coexistence, justice, companionship, and humanity, which are embedded in Japanese comics/anime, influence the values and ideology of Chinese readers. This study was aimed to examine the reading strategies and patterns in legally or illegally imported border-crossing cultural products to assess the potential cultural impact of their consumption on young Chinese readers. Their differences in passion could affect their devotion, their identity, and their worldviews. In this study, focus groups in Japan and China, in-depth interviews, and textual analyses of Japanese comic/amine were conducted to examine the reading, fandom, and cultural impact of comics/anime on Chinese urban youth. The significance of this study is that it explores new models of active reading that affect the long-term shape of and changes in the values and identities of Chinese youth. The findings of this study shed light on whether imported cultural products could transform, change, and dilute the ideologies of the state and nationalism, thereby allowing new and alternative imaginings of values and global citizenship, which are emerging areas of interest in global communication studies.

Fast heating efficiency when a pre-imploded core is directly heated with an ultraintense laser (heating laser) was investigated. ‘Direct heating’ means that a heating laser hits a pre-imploded core without applying either a laser guiding cone or an external field. The efficiency, η, is defined as the increase in the internal core energy divided by the energy of the heating laser. Six beams (output of 1.6 kJ) from the GEKKO XII (GXII) green laser system at the Institute of Laser Engineering (ILE), Osaka University were applied to implode a spherical deuterated polystyrene (CD) shell target to form a dense core. The DD-reacted protons and the core x-ray emissions showed a core density of 2.8 ± 0.7 g cm−3, or 2.6 times the solid density. Furthermore, DD-reacted thermal neutrons were utilized to estimate the core temperature between 600 and 750 eV. Thereafter, the core was directly heated by a laser for fast-ignition experiments (LFEX, an extremely energetic ultrashort pulse laser) at ILE with its axis lying along or perpendicular to the GXII bundle axis, respectively. The former and latter laser configurations were termed ‘axial’ and ‘transverse modes’, respectively. The η was estimated from three independent methods: (1) the core x-ray emission, (2) the thermal neutron yield, and (3) the runaway hot electron spectra. For the axial mode, 0.8% < η < 2.1% at low power (low LFEX energy) and 0.4% < η < 2.5% at high power (high LFEX energy). For the transverse mode, 2.6% < η < 7% at low power and 1.5% < η < 7.7% at high power. Their efficiencies were compared with that in the uniform implosion mode using 12 GXII beams, 6% < η < 12%, which appeared near to the η for the transverse mode, except that the error bar is very large.

In the counter-irradiation, which is one of the fast ignition schemes, higher core energy coupling can be expected when there are two hot electron flows in counter directions. Two plasma mirrors were installed for the counter irradiation at about 180 degrees. The hot electron effective temperatures (Teff) were measured by using electron energy spectrometers. Teff vs the laser intensity on a foil target followed Wilkes' scaling law. The energy incident on the target could be calculated by estimating the laser intensity on the target from Teff and estimating the focusing radius from the X-ray pinhole camera image. As a result, the reflectivity could be estimated to be 17 ± 3%.

Thermal fusion plasmas initiated by standing whistler waves are investigated numerically by two- and one-dimensional Particle-in-Cell simulations. When a standing whistler wave collapses due to the wave breaking of ion plasma waves, the energy of the electromagnetic waves transfers directly to the ion kinetic energy. Here we find that the ion heating by the standing whistler wave is operational even in multi-dimensional simulations of multi-ion species targets, such as deuterium-tritium (DT) ices and solid ammonia borane (H$_6$BN). The energy conversion efficiency to ions becomes as high as 15% of the injected laser energy, which depends significantly on the target thickness and laser pulse duration. The ion temperature could reach a few tens of keV or much higher if appropriate laser-plasma conditions are selected. DT fusion plasmas generated by this method must be useful as efficient neutron sources. Our numerical simulations suggest that the neutron generation efficiency exceeds 10$^9$ n/J per steradian, which is beyond the current achievements of the state-of-the-art laser experiments. The standing whistler wave heating would expand the experimental possibility for an alternative ignition design of magnetically confined laser fusion, and also for more difficult fusion reactions including the aneutronic proton-boron reaction., Comment: 16 pages, 11 figures, accepted for publication in PRE

A laser inertial fusion energy (IFE) reactor requires repetitive injection of fuel pellets and laser engagement to fuse fusion fuel beyond a few Hz. We demonstrate 10 Hz free-fall bead pellet injection and laser engagement with γ-ray generation. Deuterated polystyrene beads with a diameter of 1 mm were engaged by counter illuminating ultra-intense laser pulses with an intensity of 5 × 1017 W cm−2 at 10 Hz. The spatial distribution of free-fall beads was 0.86 mm in the horizontal direction and 0.18 mm in the vertical direction. The system operated for more than 5 min and 3500 beads were supplied with achieved frequencies of 2.1 Hz for illumination on the beads and 0.7 Hz for γ-ray generation; these frequencies were three times greater than with the previous 1 Hz injection system. The duration of operation was limited by the pellet supply. This injection and engagement system could be used for laser IFE research platforms.

The injection and engagement of pellets using laser beam irradiation is one of the key technologies to realize a laser-driven inertial fusion energy (IFE) reactor. We irradiated ultra-intense laser...

Aims: To evaluate the glycaemic control of combination therapy with basal insulin and liraglutide, and to explore the factors predictive of efficacy in patients with type 2 diabetes when switched from longstanding basal-bolus insulin therapy. Methods: We studied 41 patients who switched from basal-bolus insulin therapy of more than 3 years to basal insulin/liraglutide combination therapy. Glycaemic control was evaluated at 6 months after switching therapy and used to subdivide the patients into good-responders (HbA1c, Diabetes Research and Clinical Practice, 144, pp.161-170; 2018

The relative dose in a layer, which is thinner than the thickness of the dosimeter is evaluated using simulated depth-dose distributions, and the measured responses of dosimeters with acceleration voltages from 43 to 70 kV, via ultra-low-energy electron beam (ULEB) irradiation. By stacking thin film dosimeters, we confirmed that the simulated depth-dose distributions coincided with the measured depth-dose curve within the measurement uncertainty ( k = 2 ). Using the measurement dose of the 47 μm dosimeter and the simulated depth-dose distribution, the dose of 11 μm dosimeters in the surface was evaluated within the measurement uncertainty ( k = 2 ). We also verified the effectiveness of this method for a thinner layer by changing the acceleration voltage of the irradiation source. We evaluated the relative dose for an adjusted depth of energy deposition from 4.4 μm to 22.8 μm. As a result, this method was found to be effective for a thickness, which is less than the thickness of the dosimeter. When irradiation conditions are well known with accuracy, using the confirmed relative depth-dose distributions across any dosimeter thickness range, a dose evaluation, in several μm steps will possibly improve the design of industrial ULEB processes.

It has been reported that glucose responses during the oral glucose tolerance test differ between healthy women and men. However, it remains unknown what factors contribute to these differences between the sexes. The present study analyzed the insulin and glucagon responses during the oral glucose tolerance test in 25 female and 38 male healthy young adults aged 22–30 years. The plasma glucose levels at 120 min were significantly higher in women than men. Insulin secretion was significantly greater at 30, 90 and 120 min from baseline in women than men. Glucagon suppression was greater at 30 and 120 min from baseline in men than women when determined by a sandwich enzyme‐linked immunosorbent assay glucagon kit. These results suggest that the differences in glucose responses during the oral glucose tolerance test are mediated by the difference between the sexes in bi‐hormonal responses in healthy individuals.

The applicability of tokamak, helical and laser fusion reactors as a volumetric fusion neutron source has been examined using the systems codes that have been utilised for the conceptual design of DEMO and commercial reactors in Japan. This study has clarified the characteristics of reactor-based volumetric neutron sources that can be designed based on the current physics and engineering basis with a reasonable running cost (∼5B Yen/year). Although the achievable neutron flux is 2–3 orders lower than that of accelerator driven neutron sources, tokamak and helical neutron sources can provide a much larger irradiation area for the test of large components. Laser neutron sources have both high operability and tritium breeding capacity. These reactor-based neutron sources also serve as an integrated test bed of the entire reactor system.

Objective: Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome is a rare, chronic, relapsing inflammatory osteoarticular disorder with dermatologic manifestations. SAPHO syndrome can be a rare cause of atypical symptoms including neurologic defects. We report a case with SAPHO syndrome with the endocrinologic defects most likely associated with SAPHO syndrome.Methods: Case report and review of the literature.Results: A 61-year-old Japanese female with SAPHO syndrome presented with polyuria and polydipsia. Pituitary magnetic resonance imaging (MRI) with gadolinium enhancement showed an enlarged infundibulum and pituitary with ring-enhancing masses located at the posterior pituitary and upper infundibulum. Extensive diagnostic workup excluded local and systemic infection, brain metastasis, and various secondary hypophysitis as the cause of the infundibular and pituitary lesions. There were spontaneous improvements in the MRI findings taken 4 months after her initial presentation. The patient underwent a biopsy of the anterior pituitary, which showed a sterile lymphocytic infiltration.Conclusion: There are rare cases of SAPHO syndrome patients in which transient neurologic symptoms associated with the self-limiting ring-enhancing lesions consisting of a sterile and nonspecific inflammation are described. Since cystic formation in the infundibulum caused by idiopathic lymphocytic hypophysitis has not been reported, to the best of our knowledge, we concluded that the endocrinologic defects in our patient were most likely associated with SAPHO syndrome. Thus, SAPHO syndrome should be considered as one of the causes not only for ring-enhancing lesions in the brain but also for secondary hypophysitis, especially in patients with dermatologic and osteoarticular manifestations.

The purpose of the present study was to evaluate the pharmacokinetics of beraprost sodium (BPS) and its active enantiomer, BPS-314d, in Japanese subjects with impaired kidney function. The plasma and urine concentrations of BPS and BPS-314d were measured following the single oral administration of 120 μg of BPS as the sustained-release tablet, TRK-100STP, under fasting conditions to 18 subjects with impaired kidney function (stage 2, 3, and 4 chronic kidney disease [CKD] as categorized by the estimated glomerular filtration rate) and to 6 age-, body weight-, and gender-matched subjects with normal kidney function (stage 1 CKD). The Cmax values (mean ± SD) of BPS in stage 1, 2, 3, and 4 CKD, respectively, were 84.9 ± 22.9, 119.8 ± 36.4, 190.6 ± 137.3, and 240.2 ± 110.5 pg/mL; its AUC0-48h were 978 ± 226, 1252 ± 427, 1862 ± 964, and 1766 ± 806 pg·h/mL, respectively, and its cumulative urinary excretion rates were 0.704 ± 0.351%, 0.638 ± 0.292%, 0.485 ± 0.294%, and 0.159 ± 0.136%. The Cmax values of BPS-314d were 22.4 ± 6.4, 30.8 ± 8.5, 46.7 ± 30.6, and 54.4 ± 25.2 pg/mL, its AUC0-48h were 155 ± 56, 226 ± 67, 341 ± 176, and 329 ± 143 pg·h/mL, and its cumulative urinary excretion rates were 0.428 ± 0.242%, 0.349 ± 0.179%, 0.356 ± 0.270%, and 0.096 ± 0.099%, respectively. Adverse events were reported in 2 subjects with stage 2 CKD and 1 subject with stage 4 CKD. The Cmax and AUC0-48h of BPS and BPS-314d were higher based on the severity of impaired kidney function. No relationship was observed between the incidence of adverse events and the severity, and tolerability was confirmed. We consider that dose adjustment is not necessary, but BPS is more carefully treated in patients with impaired kidney function.

Pyridoxamine, a reactive carbonyl (RCO) scavenger, can ameliorate peritoneal deterioration in uremic peritoneal dialysis (PD) rats when given via dialysate. We examined the effects of scavenging circulating RCOs by oral pyridoxamine. Rats underwent nephrectomy and 3 weeks of twice daily PD either alone or with once daily oral pyridoxamine. PD solution was supplemented with methylglyoxal, a major glucose-derived RCO, to quench intraperitoneal pyridoxamine. Oral pyridoxamine achieved comparable blood and dialysate pyridoxamine concentrations, suppressed pentosidine accumulation in the blood but not in the mesenterium or dialysate, and reduced the increases in small solute transport and mesenteric vessel densities, with no effects on submesothelial matrix layer thickening or serum creatinine. Thus, reducing circulating RCOs by giving oral pyridoxamine with PD provides limited peritoneal protection. However, orally given pyridoxamine efficiently reaches the peritoneal cavity and would eliminate intraperitoneal RCOs. Oral pyridoxamine is more clinically favorable and may be as protective as intraperitoneal administration.

The first demonstration of target acceleration by a strong magnetic field is conducted. Two miniature targets, a gold ball and a neodymium permanent magnet, are accelerated by a magnetic field. A magnetic-field strength as high as 1 kT is produced using a capacitor-coil in which two copper disks are connected by a single-turn coil, and the capacitor was driven by two beams from the GEKKO-XII high-power laser. The targets are accelerated by the interaction force between two magnetic moments: the target and the capacitor-coil. The velocity of the accelerated gold ball was estimated as 10 m/s from shadowgraphy images. In the case of the magnet, although the image could not be observed clearly due to the plasma generated around the magnet, it was confirmed that the magnet interacts with the magnetic field of the capacitor-coil.

In laser-driven inertial fusion energy reactors, injected fuel pellets are continuously delivered into the reaction chamber and irradiated by laser beams injected at a frequency of tens of hertz. Thus far, a spherical shell pellet has been confirmed as the most conventional target design to achieve high-energy-density state thorough an implosion process that is required for fusion burn. To demonstrate repetitive fuel implosion with a 1 Hz joule-class laser system, a testbed of a shell injection system delivering a spherical shell (500 m diameter and 7 m thickness) was developed. The developed testbed demonstrated that (i) repetitive implosion (maximum frequency: 0.5 Hz) of shell injection was possible for more than ten shells at a shell speed of 191 mm s−1, and (ii) the distribution of the injected shell after 18 cm free-fall was within a circular region, 6.4 mm in diameter. The estimated laser-hit-ratio to the pellet was on the order of 10%.

Recent data suggest that several uremic toxins may contribute to the development of bone abnormalities in chronic kidney disease. p-Cresyl sulfate (PCS), the sulfate conjugate of p-cresol, is a protein-bound uremic toxin associated with the progression of chronic kidney disease, cardiovascular risk, and mortality. However, the effects of PCS on bone metabolism remain unclear. In the present study, we evaluated the toxic effects of PCS on primary mouse osteoblasts, compared with an extensively studied uremic toxin indoxyl sulfate (IS). Pre-treatment of osteoblasts with PCS at 0.125 mM and above significantly decreased parathyroid hormone (PTH)-induced cAMP production in a dose-dependent manner. PCS also induced a significant increase in intracellular production of reactive oxygen species (ROS) at 0.25 mM and above, but not at lower concentrations. PCS at 0.125 mM (a concentration that did not induce significant ROS increase) decreased cell viability by augmenting DNA fragmentation and reducing cell proliferation. Inhibition of JNK and p38 mitogen-activated protein kinase (MAPK) abolished the PCS-induced increase in DNA fragmentation and decrease in cAMP production in osteoblastic cells. Compared with PCS, IS induced ROS production at 0.05 mM but did not reduce cAMP production from 0.05 to 0.5 mM. IS induced decrease in cell viability and increase in DNA fragmentation at 0.5mM only. These results suggest that PCS damages osteoblastic cells through not only increasing ROS production but also activating JNK/p38 MAPKs, which is different from the mechanism of injury by IS. These damages of osteoblasts induced by PCS may play a critical role in impairing bone metabolism in patients with chronic kidney disease in whom PCS accumulates.

A neutron generator is developed using 1-mm-diam spherical deuterated polystyrene targets on a rotating disk irradiated with an ultrahigh-intensity (>1018 W/cm2) diode-pumped laser. It consists of ...

The purpose of the present study was to evaluate the pharmacokinetics of beraprost sodium (BPS) and its active enantiomer, BPS-314d, in Japanese subjects with impaired kidney function. The plasma and urine concentrations of BPS and BPS-314d were measured following the single oral administration of 120 μg of BPS as the sustained-release tablet, TRK-100STP, under fasting conditions to 18 subjects with impaired kidney function (stage 2, 3, and 4 chronic kidney disease [CKD] as categorized by the estimated glomerular filtration rate) and to 6 age-, body weight-, and gender-matched subjects with normal kidney function (stage 1 CKD). The C

Pyridoxamine, a reactive carbonyl (RCO) scavenger, can ameliorate peritoneal deterioration in uremic peritoneal dialysis (PD) rats when given via dialysate. We examined the effects of scavenging circulating RCOs by oral pyridoxamine. Rats underwent nephrectomy and 3 weeks of twice daily PD either alone or with once daily oral pyridoxamine. PD solution was supplemented with methylglyoxal, a major glucose-derived RCO, to quench intraperitoneal pyridoxamine. Oral pyridoxamine achieved comparable blood and dialysate pyridoxamine concentrations, suppressed pentosidine accumulation in the blood but not in the mesenterium or dialysate, and reduced the increases in small solute transport and mesenteric vessel densities, with no effects on submesothelial matrix layer thickening or serum creatinine. Thus, reducing circulating RCOs by giving oral pyridoxamine with PD provides limited peritoneal protection. However, orally given pyridoxamine efficiently reaches the peritoneal cavity and would eliminate intraperitoneal RCOs. Oral pyridoxamine is more clinically favorable and may be as protective as intraperitoneal administration.

Objectives: Sepsis caused by the bacterial contamination of blood products is a major infection risk associated with blood transfusion. Diversion of the initial 25 mL of blood and prestorage leukoreduction were implemented in Japan in 2007 for all donated blood products. We assessed the efficacy of these new collection procedures in preventing bacterial contamination of red blood cell (RBC) concentrates. Methods: Broad-range 16S ribosomal RNA polymerase chain reaction was used to determine bacterial contamination in segment samples of RBCs before and after implementation of the new collection procedures. To evaluate whether these new procedures reduced bacterial contamination, we compared bacterial contamination rates of blood samples from diversion pouches with those of segment samples from the same donor's RBCs. Results: The rate of bacterial contamination of RBCs before implementation of the new collection procedures was 1·27%. Most of the isolated bacteria were Staphylococcus epidermidis or Propionibacterium acnes. After implementation, this rate was significantly reduced to 0·10%. Of the 233 whole blood samples obtained from the Mie Red Cross Blood Center, 1·72% of blood samples from diversion pouches were contaminated, but no bacterial contamination was detected in segment samples from the same donor's RBCs after prestorage leukoreduction. Conclusions: The new collection procedure significantly reduced bacterial contamination of RBC concentrates.

A magnetic thrust chamber is an important system of a laser fusion rocket, in which the plasma kinetic energy is converted into vehicle thrust by a magnetic field. To investigate the plasma extraction from the system, the ions in a plasma are diagnosed outside the system by charge collectors. The results clearly show that the ion extraction does not strongly depend on the magnetic field strength when the energy ratio of magnetic field to plasma is greater than 4.3, and the magnetic field pushes back the plasma to generate a thrust, as previously suggested by numerical simulation and experiments.

The ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type I domain 13) related markers were measured in the plasma of healthy volunteers and thrombotic microangiopathy (TMA) patients including thrombotic thrombocytopenic purpura (TTP) to examine their efficacy in the diagnosis of TTP. The plasma levels of the ADAMTS13 antigen and ADAMTS13-factor XI complex were significantly lower in TMA patients with a significant decreased ADAMTS13 activity (and these patients were considered to have TTP) than in the healthy volunteers. The plasma levels of ADAMTS13 antigens closely correlated with those of ADAMTS13-factor XI complex. Autoantibody for ADAMTS 13 was also positive in almost all TTP patients. In addition, the ratio of von Willebrand factor (VWF)/ADAMTS13 activity was significantly high in TTP suggesting that this ratio might be more useful for the differential diagnosis of TTP than the ADAMTS13 assay alone. These findings suggest that ADAMTS13 related markers are useful for the diagnosis and analysis of TTP.

The ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type I domain 13) activity was measured by a fluorescence resonance energy transfer (FRET) assay in the plasma of healthy volunteers and thrombotic thrombocytopenic purpura (TTP) patients to examine its usefulness in the diagnosis of TTP. The plasma levels of the ADAMTS13 activity did not show a normal distribution. Its median value was 107% (range: 55-170%) in healthy volunteers, but was significantly lower in patients with TTP (acquired or familial) and in patients with hematopoietic stem cell transplantation. However, it was not significantly lower in patients with antiphospholipid syndrome (APS). The ADAMTS13 activity by a FRET assay was closely correlated with that by the ADAMTS13 multimer method (r=0.816; p0.001). In 18 patients with less than 10% of ADAMTS13 activity by FRET assay, less than 10% of that by multimer assay was 16, thus suggesting a good correlation for a low level of ADAMTS13. These findings suggest that the ADAMTS13 FRET assay correlates well with the ADAMTS13 multimer method and it is therefore useful for making a diagnosis of TTP.

A high density (1019 m−3) hydrogen plasma has been sustained successfully in axially non-uniform static magnetic field configurations for frequencies both above and below the high density limit of the lower hybrid resonance frequency (LH-HD). Wave field measurements suggest several modes are coupling to generate these helicon plasmas. The dependence of the plasma density on the static magnetic field strength for a fixed geometry can be explained by waves, with wavelength close to the antenna length, that couple to the fundamental radial mode for frequencies below the LH-HD frequency and to the second radial mode for frequencies above the LH-HD frequency.

Vascular events caused by arteriosclerosis are the major cause of death in patients under hemodialysis (HD). Arteriosclerosis is associated with lipoprotein abnormalities such as increased serum levels of low-density lipoprotein (LDL), especially of modified LDL (M-LDL) and oxidized LDL (Ox-LDL). We examined the relationship between markers of arteriosclerosis, hemostasis, and lipid metabolism in patients with chronic renal failure, hyperlipidemia, and healthy volunteers. In patients under HD, the serum levels of total cholesterol, LDL, and triglyceride (TG) were decreased, but the serum levels of M-LDL were increased compared to HL and healthy volunteers. In patients with CRF, the serum levels of OxLDL in patients under HD were lower than in those under continuous ambulatory peritoneal dialysis or conservative therapy. The plasma levels of antithrombin and protein C were significantly lower and the plasma levels of thrombomodulin were significantly higher in patients under HD compared to those under conservative therapy. These data show that patients under HD were more in hypercoagulable state than those under conservative therapy. Among patients under HD, only the plasma levels of von Willebrand factor were significantly increased in patients with more than 30 U/L of Ox-LDL compared to those with less than 30 U/L of Ox-LDL. There was no significant difference in the tests of arteriosclerosis among M-LDL values and OxLDL values. These findings suggest that abnormalities of lipid are not the main risk factor for arteriosclerosis disease in patients under HD.

We measured the plasma level of fibrinogen in 560 patients with disseminated intravascular coagulation (DIC) and evaluated its relationship with outcome and with other hemostatic markers. Forty-seven percent of patients had >200 mg/dL of plasma fibrinogen and 24% had

The ability to obtain high plasma densities with high fractional ionization using readily available, low-cost components makes the helicon a candidate plasma source for many applications, including plasma rocket propulsion, fusion component testing, and materials processing. However, operation of a helicon can be a sensitive function of the magnetic field strength and geometry as well as the driving frequency, especially when using light feedstock gases such as hydrogen or helium. In this paper, results from a coupled rf and transport model are compared with experiments in the axially inhomogeneous Mini-Radio Frequency Test Facility [Goulding et al., Proceedings of the International Conference on Electromagnetics in Advanced Applications (ICEAA 99), Torino, Italy, 1999 (Litografia Geda, Torino, 1999), p. 107] (Mini-RFTF). Experimental observations of the radial shape of the density profile can be quantitatively reproduced by iteratively converging a high-resolution rf calculation including the rf parallel electric field with a transport model using reasonable choices for the transport parameters. The experimentally observed transition into the high density helicon mode is observed in the model, appearing as a nonlinear synergism between radial diffusion, the rf coupling to parallel electric fields that damp near the plasma edge, and propagation of helicon waves that collisionally damp near the axis of the device. Power deposition from various electric field components indicates that inductive coupling and absorption in the edge region can reduce the efficiency for high-density operation. The effects of absorption near the lower hybrid resonance in the near-field region of the antenna are discussed. Ponderomotive effects are also examined and found to be significant only in very low density and edge regions of the Mini-RFTF discharge.

Fast heating is a method of heating an assembled high-density plasma into a hot state by irradiating it with short-duration (sub-picosecond), high-intensity ( W ) laser pulses before the plasma expands and dissolves hydrodynamically. In this paper, we present detailed experimental results of fast heating fuel assembled in a spherical deuterated polystyrene shell target of 500 m diameter and 7 μm thickness with counterbeam illumination by using a HAMA 1 Hz, 5.9 J inertial confinement fusion laser driver with pulse tailoring. These tailored pulses contain three pulses in sequence: a 'foot' pulse of 2.4 J/25 ns, a 'spike' pulse of 0.5 J/300 ps and a 'heater' pulse of 0.4 J/110 fs; these pulses are designed to assemble the fuel and heat it. By varying the energy of the foot pulse, we find that fast heating the fuel is achieved only if the fuel is weakly ablated by the foot pulse and then shock-assembled by the spike pulse into the target centre so that the heater pulse can access the fuel with a focal intensity greater than W . Without a foot pulse, the heater pulse contributes to assembling the fuel. For higher foot-pulse energies, the heater pulse drives a hydrodynamic motion with speeds of the order 107 cm with intensities of the order W , resulting in re-assembling and additional heating of the pre-assembled fuel. Once a shock-assembled core is achieved at the target centre, we succeed qualitatively in fast heating the core for shots in sequence with variations of laser energy within 18%. The coupling efficiency from the heating laser to the core is inferred to be % in total: % for the ionized bulk electrons and % for the bulk ions. The fusion neutron spectrum detected on the laser axis exhibits peaks at 1.0 MeV, 1.7 MeV and 3.8 MeV. These peaks are attributed to the N and He reactions induced by counterpropagating fast deuterons accelerated by the photon pressure of the heating pulses.