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862 results on '"Yoshioka, Mitsuhiro"'

11. Role of vitamin B12 on behavioral changes in SHRSP

Author

Minami, Masaru, primary, Kimura, Shin-Ichi, additional, Ueno, Ken-Ichi, additional, Endo, Toru, additional, Monma, Yoshio, additional, Togashi, Hiroko, additional, Matsumoto, Machiko, additional, Yoshioka, Mitsuhiro, additional, Saito, Hideya, additional, and Parvez, Hasan S., additional

Published
2020
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27. S-Nitrosylated Polyethylene Glycol-conjugated Hemoglobin Derivative as a Candidate Material for Oxygen Therapeutics

Author

Nakai, Kunihiko, Sakuma, Ichiro, Togashi, Hiroko, Yoshioka, Mitsuhiro, Sugawara, Takeshi, Satoh, Hiroshi, Kitabatake, Akira, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Maeda, Hiroshi, editor, Kabanov, Alexander, editor, Kataoka, Kazunori, editor, and Okano, Teruo, editor

Published
2003
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29. Monoamines and Fear-Related Behaviors

Author

Yoshioka, Mitsuhiro, Matsumoto, Machiko, Mori, Kiyoshi, Togashi, Hiroko, Nagatsu, Toshiharu, editor, Nabeshima, Toshitaka, editor, McCarty, Richard, editor, and Goldstein, David S., editor

Published
2002
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36. Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion

Author

50402798, 60177516, Kawai, Hiroyuki, Bouchekioua, Youcef, Nishitani, Naoya, Niitani, Kazuhei, Izumi, Shoma, Morishita, Hinako, Andoh, Chihiro, Nagai, Yuma, Koda, Masashi, Hagiwara, Masako, Toda, Koji, Shirakawa, Hisashi, Nagayasu, Kazuki, Ohmura, Yu, Kondo, Makoto, Kaneda, Katsuyuki, Yoshioka, Mitsuhiro, Kaneko, Shuji, 50402798, 60177516, Kawai, Hiroyuki, Bouchekioua, Youcef, Nishitani, Naoya, Niitani, Kazuhei, Izumi, Shoma, Morishita, Hinako, Andoh, Chihiro, Nagai, Yuma, Koda, Masashi, Hagiwara, Masako, Toda, Koji, Shirakawa, Hisashi, Nagayasu, Kazuki, Ohmura, Yu, Kondo, Makoto, Kaneda, Katsuyuki, Yoshioka, Mitsuhiro, and Kaneko, Shuji

Abstract

Appropriate processing of reward and aversive information is essential for survival. Although a critical role of serotonergic neurons in the dorsal raphe nucleus (DRN) in reward processing has been shown, the lack of rewarding effects with selective serotonin reuptake inhibitors (SSRIs) implies the presence of a discrete serotonergic system playing an opposite role to the DRN in the processing of reward and aversive stimuli. Here, we demonstrated that serotonergic neurons in the median raphe nucleus (MRN) of mice process reward and aversive information in opposite directions to DRN serotonergic neurons. We further identified MRN serotonergic neurons, including those projecting to the interpeduncular nucleus (5-HTMRN→IPN), as a key mediator of reward and aversive stimuli. Moreover, 5-HT receptors, including 5-HT2A receptors in the interpeduncular nucleus, are involved in the aversive properties of MRN serotonergic neural activity. Our findings revealed an essential function of MRN serotonergic neurons, including 5-HTMRN→IPN, in the processing of reward and aversive stimuli.

Published
2022

37. Behavioral characteristics of dopamine D-5 receptor knockout mice

Author

Sasamori, Hitomi, Asakura, Toshiaki, Sugiura, Chiaki, Bouchekioua, Youcef, Nishitani, Naoya, Sato, Masaaki, Yoshida, Takayuki, Yamasaki, Miwako, Terao, Akira, 1000070210945, Watanabe, Masahiko, 1000080597659, Ohmura, Yu, 1000040182729, Yoshioka, Mitsuhiro, Sasamori, Hitomi, Asakura, Toshiaki, Sugiura, Chiaki, Bouchekioua, Youcef, Nishitani, Naoya, Sato, Masaaki, Yoshida, Takayuki, Yamasaki, Miwako, Terao, Akira, 1000070210945, Watanabe, Masahiko, 1000080597659, Ohmura, Yu, 1000040182729, and Yoshioka, Mitsuhiro

Abstract

Major psychiatric disorders such as attention-deficit/hyperactivity disorder and schizophrenia are often accompanied by elevated impulsivity. However, anti-impulsive drug treatments are still limited. To explore a novel molecular target, we examined the role of dopamine D-5 receptors in impulse control using mice that completely lack D-5 receptors (D5KO mice). We also measured spontaneous activity and learning/memory ability because these deficits could confound the assessment of impulsivity. We found small but significant effects of D-5 receptor knockout on home cage activity only at specific times of the day. In addition, an analysis using the q-learning model revealed that D5KO mice displayed lower behavioral adjustment after impulsive actions. However, our results also showed that baseline impulsive actions and the effects of an anti-impulsive drug in D5KO mice were comparable to those in wild-type littermates. Moreover, unlike previous studies that used other D-5 receptor-deficient mouse lines, we did not observe reductions in locomotor activity, working memory deficits, or severe learning deficits in our line of D5KO mice. These findings demonstrate that D-5 receptors are dispensable for impulse control. Our results also indicate that time series analysis and detailed analysis of the learning process are necessary to clarify the behavioral functions of D-5 receptors.

Published
2022

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