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There is sometimes a divergence between brain atrophy and impairments in cognitive function. The present study aimed to assess the relationship between cognitive function and the grey-matter brain healthcare quotient (GM-BHQ), which represents brain volume as a deviation value. In addition, we aimed to investigate lifestyle factors that can help maintain cognitive function despite brain atrophy. A total of 1,757 adults included in a Japanese MRI brain screening cohort underwent MRI. We classified the participants into two age groups: under 65 years old (young adult/middle age group) and over 64 years old (elder group). The GM-BHQ was more strongly correlated with cognitive function in the young adult/middle age group than in the elder group (p .01). Regression analysis revealed that years of education was associated with the maintenance of cognitive function despite brain atrophy (p .05). In conclusion, our findings suggest that the relationship between brain volume and cognitive function becomes more obscure with age.

Countless studies in animals have shown how housing environments and behaviors can significantly affect anxiety and brain health, giving valuable insight as to whether this is applicable in the human context. The relationship between housing, behavior, brain health, and mental wellbeing in humans remains poorly understood. We therefore explored the interaction of housing quality, weekend/holiday sedentary behavior, brain structure, and anxiety in healthy Japanese adults. Whole-brain structural magnetic resonance imaging (MRI) methods based on gray matter volume and fractional anisotropy were used as markers for brain health. Correlation tests were conducted, and then adjusted for multiple comparisons using the False Discovery Rate method. Housing quality and weekend/holiday sedentary behavior were associated with fractional anisotropy, but not with gray matter volume. Fractional anisotropy showed significant associations with anxiety. Lastly, both weekend/holiday sedentary behavior and housing quality were indirectly associated with anxiety through fractional anisotropy. These results add to the limited evidence surrounding the relationship among housing, behavior, and the brain. Furthermore, these results show that behavior and housing qualities can have an indirect impact on anxiety through neurobiological markers such as fractional anisotropy.

This study investigated the relationship between grey matter (GM) volume and blood biomarkers, blood pressure, and obesity. We aimed to elucidate lifestyle factors that promote GM volume loss. A total of 1799 participants underwent the brain dock as a medical checkup. Data regarding blood pressure, obesity measurements, and standard blood biomarkers were obtained. Further, brain magnetic resonance imaging (MRI), including high-resolution T1-weighted imaging, was performed. We calculated the grey matter brain healthcare quotient (GM-BHQ), which represents GM volume as a deviation value. After adjusting for confounding variables, multiple regression analysis revealed that body mass index (BMI) (b = −0.28, p < 0.001), gamma-glutamyltransferase (γ-GTP) (b = −0.01, p = 0.16), and fasting blood glucose (b = −0.02, p = 0.049) were significantly correlated with GM-BHQ. Although the current cross-sectional study cannot determine a cause-and-effect relationship, elevated BMI, γ-GTP, and fasting blood glucose could promote GM volume loss.

It can be said that short-termism and excessive executive compensation are drawing critical and negative attention in recent years, judging from famous politician's lecture and the passage of law forcing to publicly disclose the ratio of the compensation of the chief executive officer (CEO) to the median compensation of that company's employees. We assume that these management problems are sharpened by human instinctive discounting behavior. By brain experiment of discounting behavior (neuro-science method), we scientifically reveal that stimuli like globalization mobilize new brain parts (precuneus, IPL, TPJ), sharpen human discounting behavior and in turn sharpen the management problems. The research results show that human beings predict other people's discounting behavior more sharply than their own by additionally activating new parts of brain. This in turn will sharpen their discount behavior. This chain of discounting behavior and activation of new brain parts becomes prominent in the globalization of economies involving more strangers. In order to stop the sharpening of management problems, improvement policies counter to human instincts become necessary. Our research results are closely related to resolve some of the problems by using accounting institutions. For example, since the institutionalization of the quarterly report promotes the short-termism, its rectification is necessary. Also, in order to correct the distortion of corporate compensation structure, the SEC oversees the disclosure of remuneration for middle-ranking worker and is seeking full-fledged institutionalization. Implementation of these accounting policies are strongly supported by our research results.

As the population ages, the realization of a long and happy life is becoming an increasingly important issue in many societies. Therefore, it is important to clarify how happiness and the brain change with aging. In this study, which was conducted with 417 healthy adults in Japan, the analysis showed that fractional anisotropy (FA) correlated with happiness, especially in the internal capsule, corona radiata, posterior thalamic radiation, cingulum, and superior longitudinal fasciculus. According to previous neuroscience studies, these regions are involved in emotional regulation. In psychological studies, emotional regulation has been associated with improvement in happiness. Therefore, this study is the first to show that FA mediates the relationship between age and subjective happiness in a way that bridges these different fields.

Aim Neurological disorders are a major public health issue worldwide and are often associated with structural changes in the brain. We have previously demonstrated that iso‐α‐acids (IAAs), the hop‐derived bitter components in beer, improve memory impairment in aged and Alzheimer's disease mouse models. In this study, we evaluated the effects of IAA intake on the brain structure in healthy middle‐aged to older adults. This study was conducted under the Impulsing Paradigm Change through Disruptive Technologies Program (ImPACT) study launched by the Cabinet office of Japan. Method This study employed an open‐labeled, single‐arm, before and after design. Healthy middle‐aged to older adults consumed a beverage containing IAAs (3 mg/190 mL) for 4 weeks.Recently developed magnetic resonance imaging‐based brain health indicators were used to evaluate the following brain conditions: the Brain Healthcare Quotient (BHQ) based on gray matter volume (GM‐BHQ) and white matter fractional anisotropy (FA‐BHQ). Results In total, 25 subjects were recruited, and GM‐BHQ and FA‐BHQ were measured before and after intervention. In all subjects, no significant differences in GM‐BHQ and FA‐BHQ were observed. In subjects aged ≥ 60 years (mean 54.5; standard deviation 3.9) (n = 8), GM‐BHQ was significantly increased 4 weeks after intervention compared with that before intervention. Conclusion Intake of beverages containing IAAs might affect brain aging, particularly in healthy older adults, which may prevent the development of neurological disorders. Future studies employing more robust designs can elucidate the effects of IAAs on GM‐BHQ and cognitive functions., This is the first clinical trial evaluating the effects of intake of bitter component of beer, iso‐alpha‐acid, on brain structure. The brain structure before and after intervention was measured by recently developed magnetic resonance imaging‐based method. The gray matter volume of older adults was improved by the intake of iso‐alpha‐acid.

The coronavirus disease (COVID-19) continues to spread globally. While social distancing has attracted attention as a measure to prevent the spread of infection, some occupations find it difficult to implement. Therefore, this study aims to investigate the relationship between work characteristics and social distancing using data available on O*NET, an occupational information site. A total of eight factors were extracted by performing an exploratory factor analysis: work conditions, supervisory work, information processing, response to aggression, specialization, autonomy, interaction outside the organization, and interdependence. A multiple regression analysis showed that interdependence, response to aggression, and interaction outside the organization, which are categorized as ”social characteristics,” and information processing and specialization, which are categorized as “knowledge characteristics,” were associated with physical proximity. Furthermore, we added customer, which represents contact with the customer, and remote working, which represents a small amount of outdoor activity, to our multiple regression model, and confirmed that they increased the explanatory power of the model. This suggests that those who work under interdependence, face aggression, and engage in outside activities, and/or have frequent contact with customers, little interaction outside the organization, and little information processing will have the most difficulty in maintaining social distancing.

The threat of coronavirus disease (COVID-19) is increasing. Regarding the differences in the infection rate observed in each region, additionally to studies investigating the causes of differences in population density as a proxy for social distancing, an increasing trend of studies investigating the causes of differences in social capital has also been seen (ie, value sharing, acceptance of norms, unity, and trust through reciprocity). However, studies investigating whether social capital that controls the effects of population density also influences the infection rate are limited. Therefore, in this study, we analyzed the relationship between infection rate, population density, and social capital using statistical data of Japan’s every prefecture. Statistical analysis showed that social capital not only negatively correlates with infection rates and population densities, but also negatively correlates with infection rates controlling for the effects of population density. Additionally, controlling the relationship between the variables by mean age showed that social capital had a greater correlation with infection rate than population density. In other words, social capital mediates the relationship between population density and infection rates, indicating that social distancing alone is not enough to deter coronavirus disease; social capital needs to be recharged.

The deep tendon reflex exam is an important part of neurological assessment of patients consisting of two components, reflex elicitation and reflex grading. While this exam has traditionally been performed in person, with trained clinicians both eliciting and grading the reflex, this work seeks to enable the exam by novices. The COVID-19 pandemic has motivated greater utilization of telemedicine and other remote healthcare delivery tools. A smart tendon hammer capable of streaming acceleration measurements wirelessly allows differentiation of correct and incorrect tapping locations with 91.5% accuracy to provide feedback to users about the appropriateness of stimulation, enabling reflex elicitation by laypeople, while survey results demonstrate that novices are reasonably able to grade reflex responses. Novice reflex grading demonstrates adequate performance with a mean error of 0.2 points on a five point scale. This work shows that by assisting in the reflex elicitation component of the reflex exam via a smart hammer and feedback application, novices should be able to complete the reflex exam remotely, filling a critical gap in neurological care during the COVID-19 pandemic.

Background: The coronavirus disease (COVID-19) is still spreading. While social distancing has attracted attention as a measure to prevent the spread of infection, some occupations find it difficult to practice it. Therefore, we decided to investigate the differences in the ease of practicing social distancing depending on the occupation using the data on O*NET, an occupational information site.Methodology: Eight factors were extracted by performing exploratory factor analysis based on certain rules while eliminating arbitrariness as much as possible: adverse conditions, leadership, information processing, response to aggression, mechanical movement, autonomy, communication with the outside, and horizontal teamwork.Results: Adverse conditions, response to aggression, and horizontal teamwork had a positive correlation with physical proximity, while information processing, mechanical movement, autonomy, and communication with the outside had a negative correlation with it. Furthermore, multiple regression analysis showed that response to aggression, not just teamwork, as assumed in previous studies, had the greatest influence on physical proximity.Conclusion: To maintain social distancing, it is necessary to constrain aggression in the workplace.

Unhealthy lifestyles are damaging to the brain. Previous studies have indicated that body mass index (BMI), alcohol intake, short sleep, smoking, and lack of exercise are negatively associated with gray matter volume (GMV). Living alone has also been found to be related to GMV through lowered subjective happiness. However, to our knowledge, no GMV study has dealt with these unhealthy lifestyles simultaneously. By our analyses based on 142 healthy Japanese participants, BMI, alcohol intake, living alone, and short sleep were negatively associated with the gray-matter brain healthcare quotient (GM-BHQ), an MRI-based normalized GMV, after controlling for age, sex, and facility, not only individually but also when they were entered into a single regression model. Moreover, there were small but significant differences in the proportion of the variance for GM-BHQ explained by variables in a regression model (measured by R squared) between when these unhealthy variables were entered in an equation at the same time and when they were entered separately, with the former larger than the latter. However, smoking and lack of exercise were not significantly associated with GM-BHQ. Results indicate that some kinds of unhealthy lifestyles are somewhat harmful on their own, but may become more noxious to brain condition if practiced simultaneously, although its difference may not be large. To our knowledge, this study is the first to show that overlapping unhealthy lifestyles affects the brains of healthy adults.

Over the past two decades, the number of studies on work engagement has increased rapidly. Work engagement refers to a positive, affective-motivational state of high energy combined with high levels of dedication and a strong focus on work, leading to various work-related outcomes, including higher work performance. Several studies have indicated that training or coaching may increase work engagement, but other studies have shown contradicting results. These inconsistencies may be due to the indirectness between training/coaching and work engagement. Therefore, we investigated the relationship between training and brain structure as well as between brain structure and work engagement in cognitively normal participants. Brain structure was assessed using neuroimaging-derived measures, including the gray-matter brain healthcare quotient (GM-BHQ) and the fractional-anisotropy brain healthcare quotient (FA-BHQ), which are approved as the international standard (H.861.1) by ITU-T. Work engagement was assessed using the Utrecht Work Engagement Scale. To validate and enrich the analysis, we employed another two representative questionnaires, which are known to be close to but different from work engagement: The Social interaction Anxiety Scale and the Maslach Burnout Inventory-General Survey to gauge the levels of human relation ineffectiveness and burnout. The latter scale is subdivided into three variables including “Exhaustion,” “Cynicism,” and “Professional Efficacy.” The results of the present study indicate that training is associated with an increase of FA-BHQ scores, and that an increase of the FA-BHQ scores is associated with an increase in Work Engagement and a decrease in Cynicism. On the other hand, the training with coaching was associated with a decrease in Interaction Anxiety. However, no correlation was observed for training with Work Engagement or the subscales of Burnout. Likewise, no correlation was observed for FA-BHQ with Exhaustion, Professional Efficacy, and Interaction Anxiety. The results of the current research provide the possibility to use brain information to evaluate training effectiveness from the viewpoint of neuroscience.

Appropriately handling and switching exploration of novel knowledge and exploitation of existing knowledge is a fundamental element of genuine innovation in society. Moreover, a mounting number of studies have suggested that such &ldquo, ambidexterity&rdquo, is associated not only with organizational performance but also with the human brain. Among these reports, however, there have not been any definitive MRI-based parameters that objectively and easily evaluate such ambidexterity. Therefore, an MRI-based index derived from gray matter volume, called the gray-matter brain healthcare quotient (GM-BHQ), was used to measure the association between ambidexterity and the entire human brain. For this purpose, 200 healthy adults were recruited as subjects to undergo structural T1-weighted imaging and to answer multiple psychological questionnaires. Ambidexterity was evaluated using two scales: the Curiosity and Exploration Inventory II and the Short Grit Scale, as exploration&ndash, exploitation indicators of curiosity and grit, respectively. Additionally, to enrich the understanding of these associations, three additional positive thinking scales were used&mdash, the General Self-Efficacy Scale, the Rosenberg Self-Esteem Scale, and the Life Orientation Test&mdash, to evaluate self-efficacy, self-esteem, and optimism, respectively. The authors discovered the GM-BHQ was weakly associated with curiosity, grit, and self-efficacy individually after controlling for age and sex. Furthermore, the GM-BHQ was directly associated with curiosity but indirectly associated with grit in the path model. However, no significant association was found between the GM-BHQ and the other outcome indicators (i.e., self-esteem and optimism). These results suggest that brain health is weakly associated with ambidexterity evaluated using psychological tests.

Workers who have limited wealth are also at a disadvantage in terms of income distribution. In accounting this brings to mind the way in which managers may limit wages by manipulating accounting information when negotiating with workers. While researchers have investigated whether or not managers manipulate information to keep workers’ wages low, they have rarely been able to produce sufficient empirical evidence to support their arguments. So we seek to bridge this gap between the present conditions and academic research. Focusing on the recent tendency for labor-management negotiations to take the form of individual bargaining between managers and workers, we conduct experiments of psychology and perform neuro-experiments using fMRI. It was found that a trend existed where managers who had a high level of empathy and would normally be expected to recognize workers’ difficult circumstances, conversely tended to compel workers to accept unfavorable outcomes.

Stress is associated with a greater risk for various health problems including reduced gray matter volume (GMV) and density in a number of brain regions. Previous studies show that neuroimaging could be a means to objectively evaluate stress. However, to date, no definite neuroimaging-derived measures are available to detect stress. In this research we used the gray-matter brain healthcare quotient (GM-BHQ), an MRI-based quotient for monitoring brain health based on GMV, as an objective scale to measure the association of stress with the whole brain. We recruited 63 healthy adults to acquire structural T1-weighted images and stress levels evaluated using three representative stress scales: the Profile of Mood States (POMS), Perceived Stress Scale (PSS) and Chalder Fatigue Scale (CFS). We found that the GM-BHQ was sensitive to fatigue and the interaction between fatigue and stress.

The paper first tries to replicate experiments by Huber (J Econ Dyn Control 31:2536---2572, 2007) and Huber et al. (J Econ Behav Org 65:86---104, 2008), which show that in double auction markets with uneven information distribution that is common knowledge, returns are a J-shaped function of the information known by different investors. Huber proposed the pattern of future earnings as the reason of J-shaped function. But our paper secondly asserts the psychological state of personal investor as the reason. It also asserts that the psychological state of personal investor often destroys efficient market. Functional magnetic resonance imaging scans of subjects in a simple game indicate that subjects with medium amounts of information use different brain areas. The paper argues that these patterns are consistent with medium-informed investors using Matching Law strategy rather than the maximizing strategy of the least and best informed investors. The paper motivates an accounting connection by remarking that financial statement disclosure is mandated in most developed stock markets.

Laparoscopic surgery is a practice of minimally invasive surgery (MIS) performed in the abdominal area. Prior to surgery, instead of exposing the target region to air as in a typical conventional open surgery, “key holes” are opened for positioning ports, through which surgical tools (e.g. laparoscope, needle drivers, etc.) are inserted. MIS therefore minimizes trauma and reduces the risk of hemorrhaging and infection. MIS also generates economic benefits such as shorter hospitalization time for patients and better utilization of operating rooms and wards for hospitals. MIS procedures, however, require extra dexterity from surgeons: they must use instruments with little to none haptic feedback to remotely manipulate tissue within a limited range of motion, assisted by an indirect view from laparoscope. Such unintuitive operations not only require additional training, but also increase the risk of medical errors. Thus, the development of novel surgical devices that can provide a better operating experience will allow surgeons to deliver safer and more effective surgeries. At the advent of MIS only rigid straight laparoscopic instruments were available. Therefore, surgeons used multiple incisions to position the tools and achieve triangulation. In single port laparoscopic surgeries (SPLS), only one incision is made for positioning a port. Two rigid straight instruments inserted through one incision cannot provide sufficient triangulation for operations. Rigid bent, or articulated, instruments can achieve triangulation, but the tools must intersect at a point. The mapping to control the end-effector, therefore, must be inverted such that the right hand controls the left end-effector, and vice versa [1]. Given this inverted mapping, surgeons need to undergo extra training to intuitively control the end-effector, and greater attention is required toward operating the device, which can potentially detract from the ability of surgeons to focus on procedures. The disadvantage of an inverted mapping can be overcome by providing additional mobility with flexible tools and actuating structures [2]. For example, Transenterix has developed a flexible laparoscopic device which utilizes a cable-driven system for articulation of the end-effectors. However, using flexible elements as the driving mechanism can result in new problems such as diminished force feedback [3]. In 2015, a novel design of an articulated single port laparoscopic device was presented with 6 degrees of freedom (DOF). The system provides intuitive control, accurate force feedback, and sufficient manipulation for laparoscopic procedures. The design proposed in this paper keeps much of the functional features in the previous model, including 1:1 mapping and force feedback, while incorporating flexible hydraulic graspers. The articulated mechanism was redesigned to have a symmetrical structure, which is more intuitive to control and provides better operating angles for surgeons. Joint structures are redesigned for enhanced robustness and misalignment prevention. Kinematic analysis is presented for the proposed mechanisms, which is used to determine the manipulator workspace.

To better understand the risk factors and optimal therapeutic strategies of cerebral white matter hyperintensity (WMH), we examined a large population of adults with and without various vascular risk factors (VRFs) or vascular risk conditions (VRCs), such as hypertension (HT), diabetes mellitus (DM), and dyslipidemia (DLP), including the comorbidities. We assessed two participant groups having no medical history of stroke or dementia that underwent brain checkup using magnetic resonance imaging (MRI): 5541 participants (2760 men, 2781 women) without VRCs and 1969 participants (1169 men, 800 women) who had received drug treatments for VRCs and the combination of comorbidities. For data analysis, we constructed WMH-brain healthcare quotient (WMH-BHQ) based on the percentile rank of WMH volume. This metric has an inverse relation to WMH. Multiple linear regression analysis of 5541 participants without VRCs revealed that age, systolic blood pressure (SBP), Brinkman index (BI), and female sex were significant factors lowering WMH-BHQ, whereas body mass index (BMI), male sex, fasting blood sugar, and triglyceride levels were increasing factors. The Kruskal&ndash, Wallis test and Dunn tests showed that WMH-BHQs significantly increased or decreased with BMI or SBP and with BI classification, respectively. Regarding the impact of impaired fasting glucose and abnormal lipid metabolism, there were almost no significant relationships. For 1969 participants who had HT, DM, and DLP, as well as their comorbidities, we found that DLP played a substantial role in increasing WMH-BHQ for some comorbidities, whereas the presence of HT and DM alone tended to decrease it. Cerebral WMH can be used as a healthcare quotient for quantitatively evaluating VRFs and VRCs and their comorbidities.

Patients with Hodgkin's disease can develop paraneoplastic cerebellar ataxia because of the generation of autoantibodies against mGluR1 (mGluR1-Abs). Yet, the pathophysiological mechanisms underlying their motor coordination deficits remain to be elucidated. Here, we show that application of IgG purified from the patients' serum to cerebellar slices of mice acutely reduces the basal activity of Purkinje cells, whereas application to the flocculus of mice in vivo evokes acute disturbances in the performance of their compensatory eye movements. In addition, the mGluR1-Abs block induction of long-term depression in cultured mouse Purkinje cells, whereas the cerebellar motor learning behavior of the patients is affected in that they show impaired adaptation of their saccadic eye movements. Finally, postmortem analysis of the cerebellum of a paraneoplastic cerebellar ataxia patient showed that the number of Purkinje cells was significantly reduced by approximately two thirds compared with three controls. We conclude that autoantibodies against mGluR1 can cause cerebellar motor coordination deficits caused by a combination of rapid effects on both acute and plastic responses of Purkinje cells and chronic degenerative effects.

Gemtuzumab ozogamicin (CMA-676), a calicheamicin-conjugated humanized anti-CD33 mouse monoclonal antibody, has recently been introduced clinically as a promising drug for the treatment of patients with acute myeloid leukemia (AML), more than 90% of which express CD33 antigen. However, our recent study suggested that CMA-676 was excreted by a multi- drug-resistance (MDR) mechanism in P-glycoprotein (P-gp)-expressing leukemia cell lines. We analyzed the in vitro effects of CMA-676 on leukemia cells from 27 AML patients in relation to the amount of P-gp, MDR-associated protein 1 (MRP1), CD33 and CD34, using a multi-laser-equipped flow cytometer. The cytocidal effect of CMA-676, estimated by the amount of hypodiploid portion on cell cycle, was inversely related to the amount of P-gp estimated by MRK16 monoclonal antibody (P = 0.004), and to the P-gp function assessed by intracellular rhodamine-123 accumulation in the presence of PSC833 or MS209 as a MDR modifier (P = 0.0004 and P = 0.002, respectively). In addition, these MDR modifiers reversed CMA-676 resistance in P-gp-expressing CD33(+) leukemia cells (P = 0.001 with PSC833 and P = 0.0007 with MS209). In CD33(+) AML cells from 13 patients, CMA-676 was less effective on CD33(+)CD34(+) than CD33(+)CD34(-) cells (P = 0.002). PSC833 partially restored the effect of CMA-676 in CD33(+)CD34(+) cells. These results suggest that the combined use of CMA-676 and a MDR modifier will be more effective on CD33(+) AML with P-gp-related MDR.

Neurological and psychiatric disorders are a burden on social and economic resources. Therefore, maintaining brain health and preventing these disorders are important. While the physiological functions of the brain are well studied, few studies have focused on keeping the brain healthy from a neuroscientific viewpoint. We propose a magnetic resonance imaging (MRI)-based quotient for monitoring brain health, the Brain Healthcare Quotient (BHQ), which is based on the volume of gray matter (GM) and the fractional anisotropy (FA) of white matter (WM). We recruited 144 healthy adults to acquire structural neuroimaging data, including T1-weighted images and diffusion tensor images, and data associated with both physical (BMI, blood pressure, and daily time use) and social (subjective socioeconomic status, subjective well-being, post-materialism and Epicureanism) factors. We confirmed that the BHQ was sensitive to an age-related decline in GM volume and WM integrity. Further analysis revealed that the BHQ was critically affected by both physical and social factors. We believe that our BHQ is a simple yet highly sensitive, valid measure for brain health research that will bridge the needs of the scientific community and society and help us lead better lives in which we stay healthy, active, and sharp.

Midazolam is a benzodiazepine and is widely prescribed for preanesthesia or general anesthesia. Overdose or intoxication cases of midazolam have been reported. In Japan, smuggled midazolam tablets could be involved in some criminal cases. Midazolam and its two metabolites were extracted by the solid-phase extraction method using Bond Elut SCX cartridges. The compounds were analyzed by on-line capillary high-performance liquid chromatography/fast atom bombardment-mass spectrometry. Midazolam and its two metabolites were well separated on the chromatogram, and each mass spectra gave [M+H](+) ion as a base peak. Deuterium-labeled midazolam was synthesized as an internal standard; it has enabled precise and reproducible quantitation of midazolam in blood samples. The calibration curve showed excellent linearity in the range of 2-200 ng/ml in spiked serum. The detection limit was 300 pg/ml (signal-to-noise ratio=3). The whole blood and urine samples from the victim of a homicide case were analyzed, and the midazolam concentration in the whole blood was estimated to be 163 ng/ml. The present method should be useful in clinical and forensic toxicology, because of its high sensitivity and specificity.

The physiological role of mGluR1-induced inward current in a Purkinje neuron was studied in a cerebellar slice preparation. In a voltage-clamp condition, application of a mGluR1 agonist (RS)-3,5-dihydroxyphenylglycine (DHPG) induced both the transient and sustained phases of inward currents, which were blocked by simultaneous application of a mGluR1 antagonist 7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxylate ethyl ester (CPCCOEt). Application of CPCCOEt alone reduced the holding inward current, suggesting that a subset of mGluRls is activated in a resting condition. In a current-clamp condition, DHPG increased the frequency of action potentials, whereas CPCCOEt decreased it. These results suggest that the basal mGluR1 activity contributes to the action potential firing by maintaining the sustained inward current in a Purkinje neuron.

In high-quality Japanese services, providers are often said to sense what their customers want from subtle cues and deliver a customized service without explicitly advertising the effort. To understand this subtle service, often called "Omonpakari," we studied a high-end Sushi restaurant using multidisciplinary approach--using neuroscience to analyze the cognitive characteristic, ethno methodology to analyze the interactive structure, and computer science to analyze the social evaluations. The study based on neuroscience showed that the service brain model could explain the cognition of "Omonpakari" service regardless of customers' gender, knowledge and the social context. The ethno methodological analysis revealed that customers performed a role, complying with cultural norms and behaving like a culturally appropriate customer even if they might not be. The analysis using computer science techniques showed that expertise was the key factor of evaluation of the services. These findings suggest an alternative model of service in which there is a productive tension, or dialectic, between the provider and the customer.

A key of brand development is the building relations of long-term trust with the customers. Trust formation is considered to be intimately linked with historical traits and/or subconscious feelings. In this study, by applying the knowledge of neuroscience, we experimentally examined the effects of customer's cognitive characteristics and context cognition on trust formed in an online environment. As a result, we found that there are methods of providing online information suited to different types of cognitive characteristics, and that there are online media expressions inducing different types of context cognition. By combining these findings, we will be able to build on a powerful technique for brand development by applying to trust formation. This method will achieve a form of service innovation in an online world by co-evolving with the progress of neuroscience research.

In our highly complex human society, social intelligence is essential for interacting with other agents (Frith et al.; 2004). One of the key elements of social intelligence is the ability to assess social compatibility (distance) between oneself and others, e.g. judging whether someone could be a friend or enemy, while also selecting proper behavioural options in our social interaction (Bogardus, 1959; Akerlof, 1997), as it influences our socioeconomic behaviours (Hoffman et al.; 1996; Charness & Gneezy, 2003; Jones & Rachlin, 2006). Across cultures, the nature of interpersonal relationships are often thought of, described and acted out in terms of physical space (e.g. “close friends” or “distant relatives”) (Ossowski, 1963; Bottero & Prandy, 2003). In our daily life, social distances are also acted out in our natural behaviours, such as our tendency to regulate “personal space” based on the degree of social connection with others (Hall, 1966; Hayduk, 1983). Moreover, it has been widely observed that there is a tendency for people to cognitively map social distances onto physical space, giving rise to psychological tools such as sandplay therapy and sociograms. However previous neuroscience studies tend to show that social intelligence has strong ties with the emotion-related brain area and the reward-related brain area (Goleman, 2006). Is the connection between spatial concepts and social concepts in linguistics and psychology only a convenient metaphor or based on deep biological roots in the brain? One intriguing possibility is that the connection between the mental representations of social relationships and those of physical space is based on common neural substrates in the brain (Ramachandran and Hubbard, 2001). In particular, since the parietal cortex is known to be involved in the self-referential operations that convert the spatial information of external objects into self-centred (i.e. egocentric) coordinates for action behaviour (Roland et al.; 1980; Rapcsak et al.; 1995; Neggers et al.; 2006; Naito et al.; 2008), the common origin hypothesis predicts that the parietal cortex should also be engaged in social distance judgments, when a self-referential process is required (Vogeley & Fink, 2003). If the parietal cortex indeed performs analogous operations in social space, such a self-referential mapping of social distance would be an efficient manner of organizing complex social information to guide interactions with others. Source: Cognitive Maps, Book edited by: Karl Perusich, ISBN 978-953-307-044-5, pp. 140, January 2010, INTECH, Croatia, downloaded from SCIYO.COM