Author: "Yoshinari Abe" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Yoshinari Abe"' showing total 96 results

Start Over Author "Yoshinari Abe"

96 results on '"Yoshinari Abe"'

1. The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder

Author: Cees J. Weeland, Selina Kasprzak, Niels T. de Joode, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Alan Anticevic, Paul D. Arnold, Srinivas Balachander, Nerisa Banaj, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Vilde Brecke, Silvia Brem, Carolina Cappi, Yuqi Cheng, Kang Ik K. Cho, Daniel L. C. Costa, Sara Dallaspezia, Damiaan Denys, Goi Khia Eng, Sónia Ferreira, Jamie D. Feusner, Martine Fontaine, Jean-Paul Fouche, Rachael G. Grazioplene, Patricia Gruner, Mengxin He, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Hao Hu, Fern Jaspers-Fayer, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-shan R. Li, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, Jose M. Menchón, Luciano Minnuzi, Pedro Silva Moreira, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Ana E. Ortiz, Jose C. Pariente, John Piacentini, Maria Picó-Pérez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Y. C. Janardhan Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Helen Blair Simpson, Noam Soreni, Carles Soriano-Mas, Nuno Sousa, Gianfranco Spalletta, Emily R. Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, Jumpei Takahashi, Tais Tanamatis, Jinsong Tang, Anders Lillevik Thorsen, David Tolin, Ysbrand D. van der Werf, Hein van Marle, Guido A. van Wingen, Daniela Vecchio, G. Venkatasubramanian, Susanne Walitza, Jicai Wang, Zhen Wang, Anri Watanabe, Lidewij H. Wolters, Xiufeng Xu, Je-Yeon Yun, Qing Zhao, ENIGMA OCD Working Group, Tonya White, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, and Chris Vriend
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Abstract Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered ( https://osf.io/73dvy ) and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (
Published: 2022
Full Text: View/download PDF

2. The Magnesium Isotope Composition of Samples Returned from Asteroid Ryugu

Author: Martin Bizzarro, Martin Schiller, Tetsuya Yokoyama, Yoshinari Abe, Jérôme Aléon, Conel M. O’D. Alexander, Sachiko Amari, Yuri Amelin, Ken-ichi Bajo, Audrey Bouvier, Richard W. Carlson, Marc Chaussidon, Byeon-Gak Choi, Nicolas Dauphas, Andrew M. Davis, Tommaso Di Rocco, Wataru Fujiya, Ryota Fukai, Ikshu Gautam, Makiko K. Haba, Yuki Hibiya, Hiroshi Hidaka, Hisashi Homma, Peter Hoppe, Gary R. Huss, Kiyohiro Ichida, Tsuyoshi Iizuka, Trevor R. Ireland, Akira Ishikawa, Shoichi Itoh, Noriyuki Kawasaki, Noriko T. Kita, Kouki Kitajima, Thorsten Kleine, Shintaro Komatani, Alexander N. Krot, Ming-Chang Liu, Yuki Masuda, Mayu Morita, Fréderic Moynier, Kazuko Motomura, Izumi Nakai, Kazuhide Nagashima, David Nesvorný, Ann Nguyen, Larry Nittler, Morihiko Onose, Andreas Pack, Changkun Park, Laurette Piani, Liping Qin, Sara S. Russell, Naoya Sakamoto, Maria Schönbächler, Lauren Tafla, Haolan Tang, Kentaro Terada, Yasuko Terada, Tomohiro Usui, Sohei Wada, Meenakshi Wadhwa, Richard J. Walker, Katsuyuki Yamashita, Qing-Zhu Yin, Shigekazu Yoneda, Edward D. Young, Hiroharu Yui, Ai-Cheng Zhang, Tomoki Nakamura, Hiroshi Naraoka, Takaaki Noguchi, Ryuji Okazaki, Kanako Sakamoto, Hikaru Yabuta, Masanao Abe, Akiko Miyazaki, Aiko Nakato, Masahiro Nishimura, Tatsuaki Okada, Toru Yada, Kasumi Yogata, Satoru Nakazawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Yuichi Tsuda, Sei-ichiro Watanabe, Makoto Yoshikawa, Shogo Tachibana, and Hisayoshi Yurimoto
Subjects: Solar system evolution, Asteroids, Carbonaceous chondrites, Meteorite composition, Nucleosynthesis, Astrophysics, QB460-466
Abstract: The nucleosynthetic isotope composition of planetary materials provides a record of the heterogeneous distribution of stardust within the early solar system. In 2020 December, the Japan Aerospace Exploration Agency Hayabusa2 spacecraft returned to Earth the first samples of a primitive asteroid, namely, the Cb-type asteroid Ryugu. This provides a unique opportunity to explore the kinship between primitive asteroids and carbonaceous chondrites. We report high-precision μ ^26 Mg* and μ ^25 Mg values of Ryugu samples together with those of CI, CM, CV, and ungrouped carbonaceous chondrites. The stable Mg isotope composition of Ryugu aliquots defines μ ^25 Mg values ranging from –160 ± 20 ppm to –272 ± 30 ppm, which extends to lighter compositions relative to Ivuna-type (CI) and other carbonaceous chondrite groups. We interpret the μ ^25 Mg variability as reflecting heterogeneous sampling of a carbonate phase hosting isotopically light Mg ( μ ^25 Mg ∼ –1400 ppm) formed by low temperature equilibrium processes. After correcting for this effect, Ryugu samples return homogeneous μ ^26 Mg* values corresponding to a weighted mean of 7.1 ± 0.8 ppm. Thus, Ryugu defines a μ ^26 Mg* excess relative to the CI and CR chondrite reservoirs corresponding to 3.8 ± 1.1 and 11.9 ± 0.8 ppm, respectively. These variations cannot be accounted for by in situ decay of ^26 Al given their respective ^27 Al/ ^24 Mg ratios. Instead, it requires that Ryugu and the CI and CR parent bodies formed from material with a different initial ^26 Al/ ^27 Al ratio or that they are sourced from material with distinct Mg isotope compositions. Thus, our new Mg isotope data challenge the notion that Ryugu and CI chondrites share a common nucleosynthetic heritage.
Published: 2023
Full Text: View/download PDF

3. Hydrogen Isotopic Composition of Hydrous Minerals in Asteroid Ryugu

Author: Laurette Piani, Kazuhide Nagashima, Noriyuki Kawasaki, Naoya Sakamoto, Ken-ichi Bajo, Yoshinari Abe, Jérôme Aléon, Conel M. O’D. Alexander, Sachiko Amari, Yuri Amelin, Martin Bizzarro, Audrey Bouvier, Richard W. Carlson, Marc Chaussidon, Byeon-Gak Choi, Nicolas Dauphas, Andrew M. Davis, Tommaso Di Rocco, Wataru Fujiya, Ryota Fukai, Ikshu Gautam, Makiko K. Haba, Yuki Hibiya, Hiroshi Hidaka, Hisashi Homma, Peter Hoppe, Gary R. Huss, Kiyohiro Ichida, Tsuyoshi Iizuka, Trevor R. Ireland, Akira Ishikawa, Shoichi Itoh, Noriko T. Kita, Kouki Kitajima, Thorsten Kleine, Shintaro Komatani, Alexander N. Krot, Ming-Chang Liu, Yuki Masuda, Kevin D. McKeegan, Mayu Morita, Kazuko Motomura, Frédéric Moynier, Izumi Nakai, Ann Nguyen, Larry Nittler, Morihiko Onose, Andreas Pack, Changkun Park, Liping Qin, Sara S. Russell, Maria Schönbächler, Lauren Tafla, Haolan Tang, Kentaro Terada, Yasuko Terada, Tomohiro Usui, Sohei Wada, Meenakshi Wadhwa, Richard J. Walker, Katsuyuki Yamashita, Qing-Zhu Yin, Tetsuya Yokoyama, Shigekazu Yoneda, Edward D. Young, Hiroharu Yui, Ai-Cheng Zhang, Tomoki Nakamura, Hiroshi Naraoka, Ryuji Okazaki, Kanako Sakamoto, Hikaru Yabuta, Masanao Abe, Akiko Miyazaki, Aiko Nakato, Masahiro Nishimura, Tatsuaki Okada, Toru Yada, Kasumi Yogata, Satoru Nakazawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Yuichi Tsuda, Sei-ichiro Watanabe, Makoto Yoshikawa, Shogo Tachibana, and Hisayoshi Yurimoto
Subjects: Carbonaceous chondrites, Earth (planet), Asteroids, Ice composition, Solar system, Small Solar System bodies, Astrophysics, QB460-466
Abstract: Rock fragments of the Cb-type asteroid Ryugu returned to Earth by the JAXA Hayabusa2 mission share mineralogical, chemical, and isotopic properties with the Ivuna-type (CI) carbonaceous chondrites. Similar to CI chondrites, these fragments underwent extensive aqueous alteration and consist predominantly of hydrous minerals likely formed in the presence of liquid water on the Ryugu parent asteroid. Here we present an in situ analytical survey performed by secondary ion mass spectrometry from which we have estimated the D/H ratio of Ryugu’s hydrous minerals, D/H _Ryugu , to be [165 ± 19] × 10 ^−6 , which corresponds to δ D _Ryugu = +59 ± 121‰ (2 σ ). The hydrous mineral D/H _Ryugu ’s values for the two sampling sites on Ryugu are similar; they are also similar to the estimated D/H ratio of hydrous minerals in the CI chondrites Orgueil and Alais. This result reinforces a link between Ryugu and CI chondrites and an inference that Ryugu’s samples, which avoided terrestrial contamination, are our best proxy to estimate the composition of water at the origin of hydrous minerals in CI-like material. Based on this data and recent literature studies, the contribution of CI chondrites to the hydrogen of Earth’s surficial reservoirs is evaluated to be ∼3%. We conclude that the water responsible for the alteration of Ryugu’s rocks was derived from water ice precursors inherited from the interstellar medium; the ice partially re-equilibrated its hydrogen with the nebular H _2 before being accreted on the Ryugu’s parent asteroid.
Published: 2023
Full Text: View/download PDF

4. White matter microstructure and its relation to clinical features of obsessive–compulsive disorder: findings from the ENIGMA OCD Working Group

Author: Fabrizio Piras, Federica Piras, Yoshinari Abe, Sri Mahavir Agarwal, Alan Anticevic, Stephanie Ameis, Paul Arnold, Nerisa Banaj, Núria Bargalló, Marcelo C. Batistuzzo, Francesco Benedetti, Jan-Carl Beucke, Premika S. W. Boedhoe, Irene Bollettini, Silvia Brem, Anna Calvo, Kang Ik Kevin Cho, Valentina Ciullo, Sara Dallaspezia, Erin Dickie, Benjamin Adam Ely, Siyan Fan, Jean-Paul Fouche, Patricia Gruner, Deniz A. Gürsel, Tobias Hauser, Yoshiyuki Hirano, Marcelo Q. Hoexter, Mariangela Iorio, Anthony James, Y. C. Janardhan Reddy, Christian Kaufmann, Kathrin Koch, Peter Kochunov, Jun Soo Kwon, Luisa Lazaro, Christine Lochner, Rachel Marsh, Akiko Nakagawa, Takashi Nakamae, Janardhanan C. Narayanaswamy, Yuki Sakai, Eiji Shimizu, Daniela Simon, Helen Blair Simpson, Noam Soreni, Philipp Stämpfli, Emily R. Stern, Philip Szeszko, Jumpei Takahashi, Ganesan Venkatasubramanian, Zhen Wang, Je-Yeon Yun, ENIGMA OCD Working Group, Dan J. Stein, Neda Jahanshad, Paul M. Thompson, Odile A. van den Heuvel, and Gianfranco Spalletta
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Abstract Microstructural alterations in cortico-subcortical connections are thought to be present in obsessive–compulsive disorder (OCD). However, prior studies have yielded inconsistent findings, perhaps because small sample sizes provided insufficient power to detect subtle abnormalities. Here we investigated microstructural white matter alterations and their relation to clinical features in the largest dataset of adult and pediatric OCD to date. We analyzed diffusion tensor imaging metrics from 700 adult patients and 645 adult controls, as well as 174 pediatric patients and 144 pediatric controls across 19 sites participating in the ENIGMA OCD Working Group, in a cross-sectional case-control magnetic resonance study. We extracted measures of fractional anisotropy (FA) as main outcome, and mean diffusivity, radial diffusivity, and axial diffusivity as secondary outcomes for 25 white matter regions. We meta-analyzed patient-control group differences (Cohen’s d) across sites, after adjusting for age and sex, and investigated associations with clinical characteristics. Adult OCD patients showed significant FA reduction in the sagittal stratum (d = −0.21, z = −3.21, p = 0.001) and posterior thalamic radiation (d = −0.26, z = −4.57, p
Published: 2021
Full Text: View/download PDF

5. Widespread distribution of radiocesium-bearing microparticles over the greater Kanto Region resulting from the Fukushima nuclear accident

Author: Yoshinari Abe, Seika Onozaki, Izumi Nakai, Kouji Adachi, Yasuhito Igarashi, Yasuji Oura, Mitsuru Ebihara, Takafumi Miyasaka, Hisashi Nakamura, Keisuke Sueki, Haruo Tsuruta, and Yuichi Moriguchi
Subjects: Fukushima Daiichi Nuclear Power Plant accident, Radiocesium-bearing microparticle, Suspended particulate matter, Synchrotron radiation X-ray analysis, Trajectory analysis, Geography. Anthropology. Recreation, Geology, QE1-996.5
Abstract: Abstract The Fukushima Daiichi Nuclear Power Plant (FDNPP) accident in March 2011 emitted a considerable amount of radioactive materials. This study isolated radiocesium-bearing microparticles (CsMPs), a form of radioactive materials emitted from the FDNPP at the early stage of the accident, from aerosols collected hourly on filter tapes at seven monitoring stations at the greater Kanto Region, including the Tokyo metropolitan area, on 15 March 2011. The aerosols had a spherical shape ~ 1 μm in diameter with activity of less than 1 Bq of 137Cs per particle. Their physical and chemical characteristics, including radioactivity ratio 134Cs/137Cs as well as chemical composition and state, are essentially the same as previously reported CsMPs. This study demonstrated that air parcels containing CsMPs emitted from the FDNPP were widespread over the greater Kanto Region, more than 250 km away from the FDNPP, during the daytime of 15 March. Trajectory analysis indicated that these particles were emitted from the reactor No. 2 of FDNPP between 14 March evening and 15 March early morning. The information obtained on the widespread distribution of CsMPs can be useful for assessing the actual impacts of radioactive contamination from the FDNPP accident on the environment and human health.
Published: 2021
Full Text: View/download PDF

6. The Oxygen Isotopic Composition of Samples Returned from Asteroid Ryugu with Implications for the Nature of the Parent Planetesimal

Author: Haolan Tang, Edward D. Young, Lauren Tafla, Andreas Pack, Tommaso Di Rocco, Yoshinari Abe, Jérôme Aléon, Conel M. O’D. Alexander, Sachiko Amari, Yuri Amelin, Ken-ichi Bajo, Martin Bizzarro, Audrey Bouvier, Richard W. Carlson, Marc Chaussidon, Byeon-Gak Choi, Nicolas Dauphas, Andrew M. Davis, Wataru Fujiya, Ryota Fukai, Ikshu Gautam, Makiko K. Haba, Yuki Hibiya, Hiroshi Hidaka, Hisashi Homma, Peter Hoppe, Gary R. Huss, Kiyohiro Ichida, Tsuyoshi Iizuka, Trevor R. Ireland, Akira Ishikawa, Motoo Ito, Shoichi Itoh, Noriyuki Kawasaki, Noriko T. Kita, Kouki Kitajima, Thorsten Kleine, Shintaro Komatani, Alexander N. Krot, Ming-Chang Liu, Yuki Masuda, Kevin D. McKeegan, Mayu Morita, Kazuko Motomura, Frédéric Moynier, Kazuhide Nagashima, Izumi Nakai, Ann Nguyen, Larry Nittler, Morihiko Onose, Changkun Park, Laurette Piani, Liping Qin, Sara S. Russell, Naoya Sakamoto, Maria Schönbächler, Kentaro Terada, Yasuko Terada, Tomohiro Usui, Sohei Wada, Meenakshi Wadhwa, Richard J. Walker, Katsuyuki Yamashita, Qing-Zhu Yin, Tetsuya Yokoyama, Shigekazu Yoneda, Hiroharu Yui, Ai-Cheng Zhang, Tomoki Nakamura, Hiroshi Naraoka, Takaaki Noguchi, Ryuji Okazaki, Kanako Sakamoto, Hikaru Yabuta, Masanao Abe, Akiko Miyazaki, Aiko Nakato, Masahiro Nishimura, Tatsuaki Okada, Toru Yada, Kasumi Yogata, Satoru Nakazawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Yuichi Tsuda, Sei-ichiro Watanabe, Makoto Yoshikawa, Shogo Tachibana, and Hisayoshi Yurimoto
Subjects: Asteroids, Planetary thermal histories, Carbonaceous chondrites, Astronomy, QB1-991
Abstract: We present oxygen isotopic analyses of fragments of the near-Earth C _b -type asteroid Ryugu returned by the Hayabusa2 spacecraft that reinforce the close correspondence between Ryugu and CI chondrites. Small differences between Ryugu samples and CI chondrites in ${{\rm{\Delta }}}^{{\prime} 17}{\rm{O}}$ can be explained at least in part by contamination of the latter by terrestrial water. The discovery that a randomly sampled C-complex asteroid is composed of CI-chondrite-like rock, combined with thermal models for formation prior to significant decay of the short-lived radioisotope ^26 Al, suggests that if lithified at the time of alteration, the parent body was small (≪50 km radius). If the parent planetesimal was large (>50 km in radius), it was likely composed of high-permeability, poorly lithified sediment rather than consolidated rock.
Published: 2023
Full Text: View/download PDF

7. A Neural Marker of Obsessive-Compulsive Disorder from Whole-Brain Functional Connectivity

Author: Yu Takagi, Yuki Sakai, Giuseppe Lisi, Noriaki Yahata, Yoshinari Abe, Seiji Nishida, Takashi Nakamae, Jun Morimoto, Mitsuo Kawato, Jin Narumoto, and Saori C Tanaka
Subjects: Medicine, Science
Abstract: Abstract Obsessive-compulsive disorder (OCD) is a common psychiatric disorder with a lifetime prevalence of 2–3%. Recently, brain activity in the resting state is gathering attention for exploring altered functional connectivity in psychiatric disorders. Although previous resting-state functional magnetic resonance imaging studies investigated the neurobiological abnormalities of patients with OCD, there are concerns that should be addressed. One concern is the validity of the hypothesis employed. Most studies used seed-based analysis of the fronto-striatal circuit, despite the potential for abnormalities in other regions. A hypothesis-free study is a promising approach in such a case, while it requires researchers to handle a dataset with large dimensions. Another concern is the reliability of biomarkers derived from a single dataset, which may be influenced by cohort-specific features. Here, our machine learning algorithm identified an OCD biomarker that achieves high accuracy for an internal dataset (AUC = 0.81; N = 108) and demonstrates generalizability to an external dataset (AUC = 0.70; N = 28). Our biomarker was unaffected by medication status, and the functional networks contributing to the biomarker were distributed widely, including the frontoparietal and default mode networks. Our biomarker has the potential to deepen our understanding of OCD and to be applied clinically.
Published: 2017
Full Text: View/download PDF

8. Artificial orpiment, a new pigment in Rembrandt’s palette

Author: Annelies van Loon, Petria Noble, Anna Krekeler, Geert Van der Snickt, Koen Janssens, Yoshinari Abe, Izumi Nakai, and Joris Dik
Subjects: Painting analysis, MA-XRF imaging, Cross-sections, Rembrandt, The Jewish Bride, Artificial orpiment, Fine Arts, Analytical chemistry, QD71-142
Abstract: Abstract This paper reports on how the application of macro X-ray fluorescence (MA-XRF) imaging, in combination with the re-examination of existing paint cross-sections, has led to the discovery of a new pigment in Rembrandt’s palette: artificial orpiment. In the NWO Science4Arts ‘ReVisRembrandt’ project, novel chemical imaging techniques are being developed and applied to the study of Rembrandt’s late paintings in order to help resolve outstanding questions and to gain a better understanding of his late enigmatic painting technique. One of the selected case studies is the Portrait of a Couple as Isaac and Rebecca, known as ‘The Jewish Bride’, dated c. 1665 and on view in the Rijksmuseum. During the re-installation of the Rijksmuseum in 2013, the picture was scanned using the Bruker M6 Jetstream MA-XRF scanner. The resulting elemental distribution maps made it possible to distinguish many features in the painting, such as bone black remains of the original hat (P, Ca maps), and the now discolored smalt-rich background (Co, Ni, As, K maps). The arsenic (As) map also revealed areas of high-intensity in Isaac’s sleeve and Rebecca’s dress where it could be established that it was not related with the pigment smalt that also contains arsenic. This pointed to the presence of a yellow or orange arsenic-containing pigment, such as realgar or orpiment that is not associated with the artist’s palette. Subsequent examination of existing paint cross-sections from these locations taken by Karin Groen in the 1990s identified isolated, almost perfectly round particles of arsenic sulfide. The round shape corresponds with published findings on a purified form of artificial orpiment glass obtained by dry processing, a sublimation reaction. In bright field, the particles characteristically exhibit a dark cross in the middle caused by internal light reflections. The results of additional non-invasive techniques (portable XRD and portable Raman) are discussed, as well as the implications of this finding and how it fits with Rembrandt’s late experimental painting technique.
Published: 2017
Full Text: View/download PDF

9. An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group

Author: Premika S. W. Boedhoe, Martijn W. Heymans, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Alan Anticevic, Paul D. Arnold, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Jamie D. Feusner, Kate D. Fitzgerald, Jean-Paul Fouche, Egill A. Fridgeirsson, Patricia Gruner, Gregory L. Hanna, Derrek P. Hibar, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Neda Jahanshad, Anthony James, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Jun Soo Kwon, Luisa Lazaro, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M. Menchón, Luciano Minuzzi, Astrid Morer, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Seiji Nishida, Erika L. Nurmi, Joseph O'Neill, John Piacentini, Fabrizio Piras, Federica Piras, Y. C. Janardhan Reddy, Tim J. Reess, Yuki Sakai, Joao R. Sato, H. Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Michael C. Stevens, Philip R. Szeszko, David F. Tolin, Guido A. van Wingen, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Je-Yeon Yun, ENIGMA-OCD Working-Group, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, and Jos W. R. Twisk
Subjects: neuroimaging, MRI, IPD meta-analysis, mega-analysis, linear mixed-effect models, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Objective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to perform well-powered meta- and mega-analyses. Some methodologists claim that a one-stage individual-participant data (IPD) mega-analysis can be superior to a two-stage aggregated data meta-analysis, since more detailed computations can be performed in a mega-analysis. Before definitive conclusions regarding the performance of either method can be drawn, it is necessary to critically evaluate the methodology of, and results obtained by, meta- and mega-analyses.Methods: Here, we compare the inverse variance weighted random-effect meta-analysis model with a multiple linear regression mega-analysis model, as well as with a linear mixed-effects random-intercept mega-analysis model, using data from 38 cohorts including 3,665 participants of the ENIGMA-OCD consortium. We assessed the effect sizes and standard errors, and the fit of the models, to evaluate the performance of the different methods.Results: The mega-analytical models showed lower standard errors and narrower confidence intervals than the meta-analysis. Similar standard errors and confidence intervals were found for the linear regression and linear mixed-effects random-intercept models. Moreover, the linear mixed-effects random-intercept models showed better fit indices compared to linear regression mega-analytical models.Conclusions: Our findings indicate that results obtained by meta- and mega-analysis differ, in favor of the latter. In multi-center studies with a moderate amount of variation between cohorts, a linear mixed-effects random-intercept mega-analytical framework appears to be the better approach to investigate structural neuroimaging data.
Published: 2019
Full Text: View/download PDF

10. Altered fronto-striatal fiber topography and connectivity in obsessive-compulsive disorder.

Author: Takashi Nakamae, Yuki Sakai, Yoshinari Abe, Seiji Nishida, Kenji Fukui, Kei Yamada, Manabu Kubota, Damiaan Denys, and Jin Narumoto
Subjects: Medicine, Science
Abstract: Fronto-striatal circuits are hypothesized to be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Within this circuitry, ventral frontal regions project fibers to the ventral striatum (VS) and dorsal frontal regions to the dorsal striatum. Resting state fMRI research has shown higher functional connectivity between the orbitofrontal cortex (OFC) and the dorsal part of the VS in OCD patients compared to healthy controls (HC). Therefore, we hypothesized that in OCD the OFC predominantly project fibers to the more dorsal part of the VS, and that the structural connectivity between the OFC and VS is higher compared to HC. A total of 20 non-medicated OCD patients and 20 HC underwent diffusion-weighted imaging. Connectivity-based parcellation analyses were performed with the striatum as seed region and the OFC, dorsolateral prefrontal cortex, and dorsal anterior cingulate cortex as target regions. Obtained connectivity maps for each frontal region of interest (ROI) were normalized into standard space, and Z-component (dorsal-ventral) coordinate of center-of-gravity (COG) were compared between two groups. Probabilistic tractography was performed to investigate diffusion indices of fibers between the striatum and frontal ROIs. COG Z-component coordinates of connectivity maps for OFC ROI were located in the more dorsal part of the VS in OCD patients compared to HC. Fractional anisotropy of fibers between the OFC and the striatum was higher in OCD patients compared to HC. Part of the pathophysiology of OCD might be understood by altered topography and structural connectivity of fibers between the OFC and the striatum.
Published: 2014
Full Text: View/download PDF

11. Pervasive aqueous alteration in the early Solar System revealed by potassium isotopic variations in Ryugu samples and carbonaceous chondrites

Author: Yan Hu, Frédéric Moynier, Wei Dai, Marine Paquet, Tetsuya Yokoyama, Yoshinari Abe, Jérôme Aléon, Conel M. O'D. Alexander, Sachiko Amari, Yuri Amelin, Ken-ichi Bajo, Martin Bizzarro, Audrey Bouvier, Richard W. Carlson, Marc Chaussidon, Byeon-Gak Choi, Nicolas Dauphas, Andrew M. Davis, Tommaso Di Rocco, Wataru Fujiya, Ryota Fukai, Ikshu Gautam, Makiko K. Haba, Yuki Hibiya, Hiroshi Hidaka, Hisashi Homma, Peter Hoppe, Gary R. Huss, Kiyohiro Ichida, Tsuyoshi Iizuka, Trevor R. Ireland, Akira Ishikawa, Shoichi Itoh, Noriyuki Kawasaki, Noriko T. Kita, Koki Kitajima, Thorsten Kleine, Shintaro Komatani, Alexander N. Krot, Ming-Chang Liu, Yuki Masuda, Mayu Morita, Kazuko Motomura, Izumi Nakai, Kazuhide Nagashima, David Nesvorný, Ann Nguyen, Larry Nittler, Morihiko Onose, Andreas Pack, Changkun Park, Laurette Piani, Liping Qin, Sara S. Russell, Naoya Sakamoto, Maria Schönbächler, Lauren Tafla, Haolan Tang, Kentaro Terada, Yasuko Terada, Tomohiro Usui, Sohei Wada, Meenakshi Wadhwa, Richard J. Walker, Katsuyuki Yamashita, Qing-Zhu Yin, Shigekazu Yoneda, Edward D. Young, Hiroharu Yui, Ai-Cheng Zhang, Tomoki Nakamura, Hiroshi Naraoka, Takaaki Noguchi, Ryuji Okazaki, Kanako Sakamoto, Hikaru Yabuta, Masanao Abe, Akiko Miyazaki, Aiko Nakato, Masahiro Nishimura, Tatsuaki Okada, Toru Yada, Kasumi Yogata, Satoru Nakazawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Yuichi Tsuda, Sei-ichiro Watanabe, Makoto Yoshikawa, Shogo Tachibana, and Hisayoshi Yurimoto
Subjects: Lunar and Planetary Science and Exploration
Abstract: C-type asteroids are the presumed home to carbonaceous chondrites, some of which contain abundant life-forming volatiles and organics. For the first time, samples from a C-type asteroid (162173 Ryugu) were successfully returned to Earth by JAXA’s Hayabusa2 mission. These pristine samples, uncontaminated by the terrestrial environment, allow a direct comparison with carbonaceous chondrites. This study reports the stable K isotopic compositions (expressed as δ41K) of Ryugu samples and seven carbonaceous chondrites to constrain the origin of K isotopic variations in the early Solar System. Three aliquots of Ryugu particles collected at two touchdown sites have identical δ41K values, averaged at -0.194 ± 0.038‰ (2SD). The K isotopic composition of Ryugu falls within the range of δ41K values measured on representative CI chondrites, and together, they define an average δ41K value of -0.185 ± 0.078‰ (2SE), which provides the current best estimate of the K isotopic composition of the bulk Solar System. Samples of CI chondrites with δ41K values that deviate from this range likely reflect terrestrial contaminations or compositional heterogeneities at sampled sizes. In addition to CI chondrites, substantial K isotopic variability is observed in other carbonaceous chondrites and within individual chondritic groups, with δ41K values inversely correlated with K abundances in many cases. These observations indicate widespread fluid activity occurred in chondrite parent bodies, which significantly altered the original K abundances and isotopic compositions of chondrules and matrices established at their accretion.
Published: 2023
Full Text: View/download PDF

12. Oxygen Isotopes of Anhydrous Primary Minerals Show Kinship Between Asteroid Ryugu and Comet 81P/Wild2

Author: Noriyuki Kawasaki, Kazuhide Nagashima, Naoya Sakamoto, Toru Matsumoto, Ken-ichi Bajo, Sohei Wada, Yohei Igami, Akira Miyake, Takaaki Noguchi, Daiki Yamamoto, Sara S Russell, Yoshinari Abe, Jérôme Aléon, Conel M O'D Alexander, Sachiko Amari, Yuri Amelin, Martin Bizzarro, Audrey Bouvier, Richard W Carlson, Marc Chaussidon, Byeon-Gak Choi, Nicolas Dauphas, Andrew M Davis, Tommaso Di Rocco, Wataru Fujiya, Ryota Fukai, Ikshu Gautam, Makiko K Haba, Yuki Hibiya, Hiroshi Hidaka, Hisashi Homma, Peter Hoppe, Gary R Huss, Kiyohiro Ichida, Tsuyoshi Iizuka, Trevor R Ireland, Akira Ishikawa, Motoo Ito, Shoichi Itoh, Noriko T Kita, Kouki Kitajima, Thorsten Kleine, Shintaro Komatani, Alexander N Krot, Ming-Chang Liu, Yuki Masuda, Kevin D McKeegan, Mayu Morita, Kazuko Motomura, Frédéric Moynier, Izumi Nakai, Ann Nguyen, Larry Nittler, Morihiko Onose, Andreas Pack, Changkun Park, Laurette Piani, Liping Qin, Maria Schönbächler, Lauren Tafla, Haolan Tang, Kentaro Terada, Yasuko Terada, Tomohiro Usui, Meenakshi Wadhwa, Richard J Walker, Katsuyuki Yamashita, Qing-Zhu Yin, Tetsuya Yokoyama, Shigekazu Yoneda, Edward D Young, Hiroharu Yui, Ai-Cheng Zhang, Tomoki Nakamura, Hiroshi Naraoka, Ryuji Okazaki, Kanako Sakamoto, Hikaru Yabuta, Masanao Abe, Akiko Miyazaki, Aiko Nakato, Masahiro Nishimura, Tatsuaki Okada, Toru Yada, Kasumi Yogata, Satoru Nakazawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Yuichi Tsuda, Sei-ichiro Watanabe, Makoto Yoshikawa, Shogo Tachibana, and Hisayoshi Yurimoto
Subjects: Lunar and Planetary Science and Exploration
Abstract: The extraterrestrial materials returned from asteroid (162173) Ryugu consist predominantly of low-temperature aqueously formed secondary minerals and are chemically and mineralogically similar to CI (Ivuna-type) carbonaceous chondrites. Here we show that high-temperature anhydrous primary minerals in Ryugu and CI chondrites exhibit a bimodal distribution of oxygen isotopic compositions: 16O-rich (associated with refractory inclusions) and 16O-poor (associated with chondrules). Both the 16O-rich and 16O-poor minerals probably formed in the inner solar protoplanetary disk and were subsequently transported outwards. The abundance ratios of the 16O-rich to 16O-poor minerals in Ryugu and CI chondrites are higher than in other carbonaceous chondrite groups, but are similar to that of comet 81P/Wild2, suggesting that Ryugu and CI chondrites accreted in the outer Solar System closer to the accretion region of comets.
Published: 2022
Full Text: View/download PDF

13. The First Returned Samples From A C-Type Asteroid Show Kinship to the Chemically Most Primitive Meteorites

Author: Tetsuya Yokoyama, Kazuhide Nagashima, Izumi Nakai, Edward D. Young, Yoshinari Abe, Jérôme Aléon, Conel M. O'D. Alexander, Sachiko Amari, Yuri Amelin, Ken-ichi Bajo, Martin Bizzarro, Audrey Bouvier, Richard W. Carlson, Marc Chaussidon, Byeon-Gak Choi, Nicolas Dauphas, Andrew M. Davis, Tommaso Di Rocco, Wataru Fujiya, Ryota Fukai, Ikshu Gautam, Makiko K. Haba, Yuki Hibiya, Hiroshi Hidaka, Hisashi Homma, Peter Hoppe, Gary R. Huss, Kiyohiro Ichida, Tsuyoshi Iizuka, Trevor R. Ireland, Akira Ishikawa, Motoo Ito, Shoichi Itoh, Noriyuki Kawasaki, Noriko T. Kita, Kouki Kitajima, Thorsten Kleine, Shintaro Komatani, and Ann Nguyen
Subjects: Chemistry And Materials (General), Space Sciences (General)
Abstract: Bulk chemical and isotopic compositions, and mineralogy in the asteroid (162173) Ryugu samples show that Ryugu is mainly composed of materials related to the CI (Ivuna-like) carbonaceous chondrite group. The samples consist predominantly of minerals produced by aqueous alteration in a parent planetesimal from which Ryugu was derived. The 53Mn-53Cr systematics of dolomite suggest that this alteration occurred 5.2 (+0.7/–0.8) million years after formation of Ca-Al-rich inclusions, the first solids formed in the Solar System. The aqueous alteration temperature at the time dolomite and magnetite coprecipitated was 37±10°C. Unlike in CI chondrites, phyllosilicates in Ryugu have lost most of their interlayer water, but retained structural water. This indicates that following aqueous alteration the Ryugu samples avoided heating above ~90°C.
Published: 2022
Full Text: View/download PDF

14. Presolar Stardust in Asteroid Ryugu

Author: Jens Barosch, Larry R. Nittler, Jianhua Wang, Conel M. O’D. Alexander, Bradley T. De Gregorio, Cécile Engrand, Yoko Kebukawa, Kazuhide Nagashima, Rhonda M. Stroud, Hikaru Yabuta, Yoshinari Abe, Jérôme Aléon, Sachiko Amari, Yuri Amelin, Ken-ichi Bajo, Laure Bejach, Martin Bizzarro, Lydie Bonal, Audrey Bouvier, Richard W. Carlson, Marc Chaussidon, Byeon-Gak Choi, George D. Cody, Emmanuel Dartois, Nicolas Dauphas, Andrew M. Davis, Alexandre Dazzi, Ariane Deniset-Besseau, Tommaso Di Rocco, Jean Duprat, Wataru Fujiya, Ryota Fukai, Ikshu Gautam, Makiko K. Haba, Minako Hashiguchi, Yuki Hibiya, Hiroshi Hidaka, Hisashi Homma, Peter Hoppe, Gary R. Huss, Kiyohiro Ichida, Tsuyoshi Iizuka, Trevor R. Ireland, Akira Ishikawa, Motoo Ito, Shoichi Itoh, Kanami Kamide, Noriyuki Kawasaki, A. L. David Kilcoyne, Noriko T. Kita, Kouki Kitajima, Thorsten Kleine, Shintaro Komatani, Mutsumi Komatsu, Alexander N. Krot, Ming-Chang Liu, Zita Martins, Yuki Masuda, Jérémie Mathurin, Kevin D. McKeegan, Gilles Montagnac, Mayu Morita, Smail Mostefaoui, Kazuko Motomura, Frédéric Moynier, Izumi Nakai, Ann N. Nguyen, Takuji Ohigashi, Taiga Okumura, Morihiko Onose, Andreas Pack, Changkun Park, Laurette Piani, Liping Qin, Eric Quirico, Laurent Remusat, Sara S. Russell, Naoya Sakamoto, Scott A. Sandford, Maria Schönbächler, Miho Shigenaka, Hiroki Suga, Lauren Tafla, Yoshio Takahashi, Yasuo Takeichi, Yusuke Tamenori, Haolan Tang, Kentaro Terada, Yasuko Terada, Tomohiro Usui, Maximilien Verdier-Paoletti, Sohei Wada, Meenakshi Wadhwa, Daisuke Wakabayashi, Richard J. Walker, Katsuyuki Yamashita, Shohei Yamashita, Qing-Zhu Yin, Tetsuya Yokoyama, Shigekazu Yoneda, Edward D. Young, Hiroharu Yui, Ai-Cheng Zhang, Masanao Abe, Akiko Miyazaki, Aiko Nakato, Satoru Nakazawa, Masahiro Nishimura, Tatsuaki Okada, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Yuichi Tsuda, Sei-ichiro Watanabe, Toru Yada, Kasumi Yogata, Makoto Yoshikawa, Tomoki Nakamura, Hiroshi Naraoka, Takaaki Noguchi, Ryuji Okazaki, Kanako Sakamoto, Shogo Tachibana, and Hisayoshi Yurimoto
Published: 2022
Full Text: View/download PDF

15. A common brain network among state, trait, and pathological anxiety from whole-brain functional connectivity.

Author: Yu Takagi, Yuki Sakai, Yoshinari Abe, Seiji Nishida, Ben J. Harrison, Ignacio Martínez-Zalacaín, Carles Soriano-Mas, Jin Narumoto, and Saori C. Tanaka
Published: 2018
Full Text: View/download PDF

16. Provenance and Trade of Ancient Glass Revealed by X-ray Analysis

Author: Yoshinari ABE and Madoka MURAKUSHI
Published: 2022

17. Contribution of Ryugu-like material to Earth’s volatile inventory by Cu and Zn isotopic analysis

Author: Marine Paquet, Frederic Moynier, Tetsuya Yokoyama, Wei Dai, Yan Hu, Yoshinari Abe, Jérôme Aléon, Conel M. O’D. Alexander, Sachiko Amari, Yuri Amelin, Ken-ichi Bajo, Martin Bizzarro, Audrey Bouvier, Richard W. Carlson, Marc Chaussidon, Byeon-Gak Choi, Nicolas Dauphas, Andrew M. Davis, Tommaso Di Rocco, Wataru Fujiya, Ryota Fukai, Ikshu Gautam, Makiko K. Haba, Yuki Hibiya, Hiroshi Hidaka, Hisashi Homma, Peter Hoppe, Gary R. Huss, Kiyohiro Ichida, Tsuyoshi Iizuka, Trevor R. Ireland, Akira Ishikawa, Motoo Ito, Shoichi Itoh, Noriyuki Kawasaki, Noriko T. Kita, Kouki Kitajima, Thorsten Kleine, Shintaro Komatani, Alexander N. Krot, Ming-Chang Liu, Yuki Masuda, Kevin D. McKeegan, Mayu Morita, Kazuko Motomura, Izumi Nakai, Kazuhide Nagashima, David Nesvorný, Ann N. Nguyen, Larry Nittler, Morihiko Onose, Andreas Pack, Changkun Park, Laurette Piani, Liping Qin, Sara S. Russell, Naoya Sakamoto, Maria Schönbächler, Lauren Tafla, Haolan Tang, Kentaro Terada, Yasuko Terada, Tomohiro Usui, Sohei Wada, Meenakshi Wadhwa, Richard J. Walker, Katsuyuki Yamashita, Qing-Zhu Yin, Shigekazu Yoneda, Edward D. Young, Hiroharu Yui, Ai-Cheng Zhang, Tomoki Nakamura, Hiroshi Naraoka, Takaaki Noguchi, Ryuji Okazaki, Kanako Sakamoto, Hikaru Yabuta, Masanao Abe, Akiko Miyazaki, Aiko Nakato, Masahiro Nishimura, Tatsuaki Okada, Toru Yada, Kasumi Yogata, Satoru Nakazawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Yuichi Tsuda, Sei-ichiro Watanabe, Makoto Yoshikawa, Shogo Tachibana, and Hisayoshi Yurimoto
Subjects: Astronomy and Astrophysics
Abstract: Initial analyses showed that asteroid Ryugu's composition is close to CI (Ivuna-like) carbonaceous chondrites (CCs) - the chemically most primitive meteorites, characterized by near-solar abundances for most elements. However, some isotopic signatures (for example, Ti, Cr) overlap with other CC groups, so the details of the link between Ryugu and the CI chondrites are not yet fully clear. Here we show that Ryugu and CI chondrites have the same zinc and copper isotopic composition. As the various chondrite groups have very distinct Zn and Cu isotopic signatures, our results point at a common genetic heritage between Ryugu and CI chondrites, ruling out any affinity with other CC groups. Since Ryugu's pristine samples match the solar elemental composition for many elements, their Zn and Cu isotopic compositions likely represent the best estimates of the solar composition. Earth's mass-independent Zn isotopic composition is intermediate between Ryugu/CC and non-carbonaceous chondrites (NCs), suggesting a contribution of Ryugu-like material to Earth's budgets of Zn and other moderately volatile elements.
Published: 2022

18. Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium

Author: Iliyan Ivanov, Premika S.W. Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Paul D. Arnold, Srinivas Balachander, Justin T. Baker, Nerisa Banaj, Nuria Bargalló, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Silvia Brem, Brian P. Brennan, Jan Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Sara Dallaspezia, Damiaan Denys, Juliana B. Diniz, Benjamin A. Ely, Jamie D. Feusner, Sónia Ferreira, Kate D. Fitzgerald, Martine Fontaine, Patricia Gruner, Gregory L. Hanna, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Keisuke Ikari, Anthony James, Fern Jaspers-Fayer, Hongyan Jiang, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Jun Soo Kwon, Luisa Lázaro, Yanni Liu, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M. Menchón, Luciano Minuzzi, Astrid Morer, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Sanghoon Oh, Chris Perriello, John C. Piacentini, Maria Picó-Pérez, Fabrizio Piras, Federica Piras, Y.C. Janardhan Reddy, Daniela Rodriguez Manrique, Yuki Sakai, Eiji Shimizu, H. Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Emily R. Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, David F. Tolin, Daan van Rooij, Dick J. Veltman, Ysbrand D. van der Werf, Guido A. van Wingen, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Anri Watanabe, Lidewij H. Wolters, Xiufeng Xu, Je-Yeon Yun, Mojtaba Zarei, Fengrui Zhang, Qing Zhao, Neda Jahanshad, Sophia I. Thomopoulos, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Joseph O'Neill, Sara Poletti, Egill Axfjord Fridgeirsson, Toshikazu Ikuta, Stella J. de Wit, Chris Vriend, Selina Kasprzak, Masaru Kuno, Jumpei Takahashi, Euripedes C. Miguel, Roseli G. Shavitt, Morgan Hough, Jose C. Pariente, Ana E. Ortiz, Sara Bertolín, Eva Real, Cinto Segalàs, Pedro Silva Moreira, Nuno Sousa, Jin Narumoto, Kei Yamada, Jinsong Tang, Jean-Paul Fouche, Taekwan Kim, Sunah Choi, Minji Ha, Sunghyun Park, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Systems & Network Neuroscience, Amsterdam Neuroscience - Neurodegeneration, Adult Psychiatry, Child Psychiatry, Paediatric Psychosocial Care, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Graduate School, Ivanov, Iliyan, Boedhoe, Premika S W, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H, Arnold, Paul D, Balachander, Sriniva, Baker, Justin T, Banaj, Nerisa, Bargalló, Nuria, Batistuzzo, Marcelo C, Benedetti, Francesco, Beucke, Jan C, Bollettini, Irene, Brem, Silvia, Brennan, Brian P, Buitelaar, Jan, Calvo, Rosa, Cheng, Yuqi, Cho, Kang Ik K, Dallaspezia, Sara, Denys, Damiaan, Diniz, Juliana B, Ely, Benjamin A, Feusner, Jamie D, Ferreira, Sónia, Fitzgerald, Kate D, Fontaine, Martine, Gruner, Patricia, Hanna, Gregory L, Hirano, Yoshiyuki, Hoexter, Marcelo Q, Huyser, Chaim, Ikari, Keisuke, James, Anthony, Jaspers-Fayer, Fern, Jiang, Hongyan, Kathmann, Norbert, Kaufmann, Christian, Kim, Minah, Koch, Kathrin, Kwon, Jun Soo, Lázaro, Luisa, Liu, Yanni, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José M, Minuzzi, Luciano, Morer, Astrid, Morgado, Pedro, Nakagawa, Akiko, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nurmi, Erika L, Oh, Sanghoon, Perriello, Chri, Piacentini, John C, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Reddy, Y C Janardhan, Manrique, Daniela Rodriguez, Sakai, Yuki, Shimizu, Eiji, Simpson, H Blair, Soreni, Noam, Soriano-Mas, Carle, Spalletta, Gianfranco, Stern, Emily R, Stevens, Michael C, Stewart, S Evelyn, Szeszko, Philip R, Tolin, David F, van Rooij, Daan, Veltman, Dick J, van der Werf, Ysbrand D, van Wingen, Guido A, Venkatasubramanian, Ganesan, Walitza, Susanne, Wang, Zhen, Watanabe, Anri, Wolters, Lidewij H, Xu, Xiufeng, Yun, Je-Yeon, Zarei, Mojtaba, Zhang, Fengrui, Zhao, Qing, Jahanshad, Neda, Thomopoulos, Sophia I, Thompson, Paul M, Stein, Dan J, van den Heuvel, Odile A, and O'Neill, Joseph
Subjects: Obsessive-Compulsive Disorder, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], OCD, Psychotropics, Longevity, SRIs, Magnetic Resonance Imaging, Benzodiazepines, Psychiatry and Mental health, Clinical Psychology, Age, Cross-Sectional Studies, Subcortical volumes, 130 000 Cognitive Neurology & Memory, Child, Preschool, Serotonin Uptake Inhibitors, Humans, Child, Selective Serotonin Reuptake Inhibitors, Aged, Antipsychotic Agents
Abstract: Background: Widely used psychotropic medications for obsessive-compulsive disorder (OCD) may change the volumes of subcortical brain structures, and differently in children vs. adults. We measured subcortical volumes cross-sectionally in patients finely stratified for age taking various common classes of OCD drugs. Methods: The ENIGMA-OCD consortium sample (1081 medicated/1159 unmedicated OCD patients and 2057 healthy controls aged 6–65) was divided into six successive 6–10-year age-groups. Individual structural MRIs were parcellated automatically using FreeSurfer into 8 regions-of-interest (ROIs). ROI volumes were compared between unmedicated and medicated patients and controls, and between patients taking serotonin reuptake inhibitors (SRIs), tricyclics (TCs), antipsychotics (APs), or benzodiazepines (BZs) and unmedicated patients. Results: Compared to unmedicated patients, volumes of accumbens, caudate, and/or putamen were lower in children aged 6–13 and adults aged 50–65 with OCD taking SRIs (Cohen's d = −0.24 to −0.74). Volumes of putamen, pallidum (d = 0.18–0.40), and ventricles (d = 0.31–0.66) were greater in patients aged 20–29 receiving APs. Hippocampal volumes were smaller in patients aged 20 and older taking TCs and/or BZs (d = −0.27 to −1.31). Conclusions: Results suggest that TCs and BZs could potentially aggravate hippocampal atrophy of normal aging in older adults with OCD, whereas SRIs may reduce striatal volumes in young children and older adults. Similar to patients with psychotic disorders, OCD patients aged 20–29 may experience subcortical nuclear and ventricular hypertrophy in relation to APs. Although cross-sectional, present results suggest that commonly prescribed agents exert macroscopic effects on subcortical nuclei of unknown relation to therapeutic response.
Published: 2022

19. Author Correction: Contribution of Ryugu-like material to Earth’s volatile inventory by Cu and Zn isotopic analysis

Author: Marine Paquet, Frederic Moynier, Tetsuya Yokoyama, Wei Dai, Yan Hu, Yoshinari Abe, Jérôme Aléon, Conel M. O’D. Alexander, Sachiko Amari, Yuri Amelin, Ken-ichi Bajo, Martin Bizzarro, Audrey Bouvier, Richard W. Carlson, Marc Chaussidon, Byeon-Gak Choi, Nicolas Dauphas, Andrew M. Davis, Tommaso Di Rocco, Wataru Fujiya, Ryota Fukai, Ikshu Gautam, Makiko K. Haba, Yuki Hibiya, Hiroshi Hidaka, Hisashi Homma, Peter Hoppe, Gary R. Huss, Kiyohiro Ichida, Tsuyoshi Iizuka, Trevor R. Ireland, Akira Ishikawa, Motoo Ito, Shoichi Itoh, Noriyuki Kawasaki, Noriko T. Kita, Kouki Kitajima, Thorsten Kleine, Shintaro Komatani, Alexander N. Krot, Ming-Chang Liu, Yuki Masuda, Kevin D. McKeegan, Mayu Morita, Kazuko Motomura, Izumi Nakai, Kazuhide Nagashima, David Nesvorný, Ann N. Nguyen, Larry Nittler, Morihiko Onose, Andreas Pack, Changkun Park, Laurette Piani, Liping Qin, Sara S. Russell, Naoya Sakamoto, Maria Schönbächler, Lauren Tafla, Haolan Tang, Kentaro Terada, Yasuko Terada, Tomohiro Usui, Sohei Wada, Meenakshi Wadhwa, Richard J. Walker, Katsuyuki Yamashita, Qing-Zhu Yin, Shigekazu Yoneda, Edward D. Young, Hiroharu Yui, Ai-Cheng Zhang, Tomoki Nakamura, Hiroshi Naraoka, Takaaki Noguchi, Ryuji Okazaki, Kanako Sakamoto, Hikaru Yabuta, Masanao Abe, Akiko Miyazaki, Aiko Nakato, Masahiro Nishimura, Tatsuaki Okada, Toru Yada, Kasumi Yogata, Satoru Nakazawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Yuichi Tsuda, Sei-ichiro Watanabe, Makoto Yoshikawa, Shogo Tachibana, and Hisayoshi Yurimoto
Subjects: Astronomy and Astrophysics
Abstract: Correction to: Nature Astronomy https://doi.org/10.1038/s41550-022-01846-1. Published online 12 December 2022.
Published: 2022

20. The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Author: Willem B. Bruin, Yoshinari Abe, Pino Alonso, Alan Anticevic, Srinivas Balachander, Nuria Bargallo, Marcelo Camargo Batistuzzo, Francesco Benedetti, Sara Bertolín, Silvia Brem, Federico Calesella, beatriz couto, Damiaan Denys, Marco A.N. Echevarria, Goi Khia Eng, Sónia Ferreira, Jamie Feusner, Rachael Grazioplene, Patricia Gruner, Joyce Y. Guo, Kristen Hagen, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Queiroz Hoexter, Neda Jahanshad, Fern Jaspers-Fayer, Selina Kasprzak, Minah Kim, kathrin koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-Shan R. Li, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, Jose M. Menchon, Pedro Silva Moreira, Pedro Morgado, Akiko Nakagawa, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Jose C. Pariente Zorrilla, John Piacentini, Maria Picó-Pérez, Federica Piras, Fabrizio Piras, Christopher Pittenger, Janardhan Y.C. Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Blair H. Simpson, Carles Soriano-Mas, Nuno Sousa, Gianfranco Spalletta, Emily R. Stern, S. Evelyn Stewart, Philip R. Szeszko, Jinsong Tang, Sophia I Thomopoulos, Anders Lillevik Thorsen, Yoshida Tokiko, Hirofumi Tomiyama, Benedetta Vai, Ilya Veer, Venkatasubramanian G, Nora C. Vetter, Chris Vriend, Susanne Walitza, Lea Waller, Zhen Wang, Anri Watanabe, Nicole Wolff, Je-Yeon Yun, Qing Zhao, Wieke A. van Leeuwen, Hein J.F. van Marle, Laurens A. van de Mortel, Anouk van der Straten, Ysbrand van der Werf, Paul Thompson, Dan J. Stein, Odile A. van den Heuvel, and Guido van Wingen
Abstract: Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, the majority of studies have focused only on predefined regions or functional networks rather than connectivity throughout the entire brain. Here, we investigated differences in resting-state functional connectivity between OCD patients and healthy controls (HC) using mega-analysis of data from 1,024 OCD patients and 1,028 HC from 28 independent samples of the ENIGMA-OCD consortium. We assessed group differences in whole-brain functional connectivity at both the regional and network level, and investigated whether functional connectivity could serve as biomarker to identify patient status at the individual level using machine learning analysis. The mega-analyses revealed widespread abnormalities in functional connectivity in OCD, with global hypo-connectivity (Cohen’s d: -0.27 to -0.13) and few hyper-connections, mainly with the thalamus (Cohen’s d: 0.19 to 0.22). Most hypo-connections were located within the sensorimotor network and no fronto-striatal abnormalities were found. Overall, classification performances were poor, with area-under-the-receiver-operating-characteristic curve (AUC) scores ranging between 0.567 and 0.673, with better classification for medicated (AUC=0.702) than unmedicated (AUC=0.608) patients versus healthy controls. These findings provide partial support for existing pathophysiological models of OCD and highlight the important role of the sensorimotor network in OCD. However, resting-state connectivity does not so far provide an accurate biomarker for identifying patients at the individual level.
Published: 2022

21. Samples returned from the asteroid Ryugu are similar to Ivuna-type carbonaceous meteorites

Author: Tetsuya Yokoyama, Kazuhide Nagashima, Izumi Nakai, Edward D. Young, Yoshinari Abe, Jérôme Aléon, Conel M. O’D. Alexander, Sachiko Amari, Yuri Amelin, Ken-ichi Bajo, Martin Bizzarro, Audrey Bouvier, Richard W. Carlson, Marc Chaussidon, Byeon-Gak Choi, Nicolas Dauphas, Andrew M. Davis, Tommaso Di Rocco, Wataru Fujiya, Ryota Fukai, Ikshu Gautam, Makiko K. Haba, Yuki Hibiya, Hiroshi Hidaka, Hisashi Homma, Peter Hoppe, Gary R. Huss, Kiyohiro Ichida, Tsuyoshi Iizuka, Trevor R. Ireland, Akira Ishikawa, Motoo Ito, Shoichi Itoh, Noriyuki Kawasaki, Noriko T. Kita, Kouki Kitajima, Thorsten Kleine, Shintaro Komatani, Alexander N. Krot, Ming-Chang Liu, Yuki Masuda, Kevin D. McKeegan, Mayu Morita, Kazuko Motomura, Frédéric Moynier, Ann Nguyen, Larry Nittler, Morihiko Onose, Andreas Pack, Changkun Park, Laurette Piani, Liping Qin, Sara S. Russell, Naoya Sakamoto, Maria Schönbächler, Lauren Tafla, Haolan Tang, Kentaro Terada, Yasuko Terada, Tomohiro Usui, Sohei Wada, Meenakshi Wadhwa, Richard J. Walker, Katsuyuki Yamashita, Qing-Zhu Yin, Shigekazu Yoneda, Hiroharu Yui, Ai-Cheng Zhang, Harold C. Connolly, Dante S. Lauretta, Tomoki Nakamura, Hiroshi Naraoka, Takaaki Noguchi, Ryuji Okazaki, Kanako Sakamoto, Hikaru Yabuta, Masanao Abe, Masahiko Arakawa, Atsushi Fujii, Masahiko Hayakawa, Naoyuki Hirata, Naru Hirata, Rie Honda, Chikatoshi Honda, Satoshi Hosoda, Yu-ichi Iijima, Hitoshi Ikeda, Masateru Ishiguro, Yoshiaki Ishihara, Takahiro Iwata, Kosuke Kawahara, Shota Kikuchi, Kohei Kitazato, Koji Matsumoto, Moe Matsuoka, Tatsuhiro Michikami, Yuya Mimasu, Akira Miura, Tomokatsu Morota, Satoru Nakazawa, Noriyuki Namiki, Hirotomo Noda, Rina Noguchi, Naoko Ogawa, Kazunori Ogawa, Tatsuaki Okada, Chisato Okamoto, Go Ono, Masanobu Ozaki, Takanao Saiki, Naoya Sakatani, Hirotaka Sawada, Hiroki Senshu, Yuri Shimaki, Kei Shirai, Seiji Sugita, Yuto Takei, Hiroshi Takeuchi, Satoshi Tanaka, Eri Tatsumi, Fuyuto Terui, Yuichi Tsuda, Ryudo Tsukizaki, Koji Wada, Sei-ichiro Watanabe, Manabu Yamada, Tetsuya Yamada, Yukio Yamamoto, Hajime Yano, Yasuhiro Yokota, Keisuke Yoshihara, Makoto Yoshikawa, Kent Yoshikawa, Shizuho Furuya, Kentaro Hatakeda, Tasuku Hayashi, Yuya Hitomi, Kazuya Kumagai, Akiko Miyazaki, Aiko Nakato, Masahiro Nishimura, Hiromichi Soejima, Ayako Suzuki, Toru Yada, Daiki Yamamoto, Kasumi Yogata, Miwa Yoshitake, Shogo Tachibana, Hisayoshi Yurimoto, Cosmochimie [IMPMC] (IMPMC_COSMO), Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique du Globe de Paris (IPGP (UMR_7154)), Institut national des sciences de l'Univers (INSU - CNRS)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre de Recherches Pétrographiques et Géochimiques (CRPG), and Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Multidisciplinary, [SDU]Sciences of the Universe [physics]
Abstract: Carbonaceous meteorites are thought to be fragments of C-type (carbonaceous) asteroids. Samples of the C-type asteroid (162173) Ryugu were retrieved by the Hayabusa2 spacecraft. We measured the mineralogy and bulk chemical and isotopic compositions of Ryugu samples. The samples are mainly composed of materials similar to those of carbonaceous chondrite meteorites, particularly the CI (Ivuna-type) group. The samples consist predominantly of minerals formed in aqueous fluid on a parent planetesimal. The primary minerals were altered by fluids at a temperature of 37° ± 10°C, about 5.2 − 0.7 + 0.8 million (statistical) or 5.2 − 2.1 + 1.6 million (systematic) years after the formation of the first solids in the Solar System. After aqueous alteration, the Ryugu samples were likely never heated above ~100°C. The samples have a chemical composition that more closely resembles that of the Sun’s photosphere than other natural samples do.
Published: 2022

22. An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group.

Author: Premika S. W. Boedhoe, Martijn W. Heymans, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Alan Anticevic, Paul D. Arnold, Marcelo C. Batistuzzo, Francesco Benedetti, Jan Carl Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Rosa Calvo, Yuqi Cheng, Kang Ik Kevin Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Jamie D. Feusner, Kate Dimond Fitzgerald, Jean-Paul Fouche, Egill A. Fridgeirsson, Patricia Gruner, Gregory L. Hanna, Derrek P. Hibar, Marcelo Queiroz Hoexter, Hao Hu, Chaim Huyser, Neda Jahanshad, Anthony James, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Jun Soo Kwon, Luisa Lazaro, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José Manuel Menchón, Luciano Minuzzi, Astrid Morer, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Seiji Nishida, Erika L. Nurmi, Joseph O'Neill, John Piacentini, Fabrizio Piras, Federica Piras, Y. C. Janardhan Reddy, Tim Jonas Reess, Yuki Sakai, João R. Sato, H. Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Michael C. Stevens 0001, Philip R. Szeszko, David F. Tolin, Guido A. van Wingen, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang 0015, Je-Yeon Yun, ENIGMA-OCD Working-Group, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, and Jos W. R. Twisk
Published: 2018
Full Text: View/download PDF

23. Proposal of a Compositional Characterization Method by Semi-quantitative Analysis of XRF Spectrum of Pigments in Mural Painting and Its Application to Nondestructive On-site Analysis of the Murals of the Tomb of Khonsuemheb in Egypt

Author: Yoshinari Abe, Izumi Nakai, Haruka Ebisawa, Kazumitsu Takahashi, Jiro Kondo, Eri Ogidani, Nozomu Kawai, and Haruka Hidaka
Subjects: Painting, Ancient egypt, media_common.quotation_subject, Mural, Art, Site analysis, Archaeology, Semi quantitative, Analytical Chemistry, Characterization (materials science), Archaeological science, media_common
Published: 2020

24. Japanese Project for Telepsychiatry Evaluation during COVID-19: Treatment Comparison Trial (J-PROTECT): Rationale, design, and methodology

Author: Takashi Nakamae, Maki Takamiya, Akitoyo Hishimoto, Takaharu Azekawa, Toshiaki Kikuchi, Akihiro Takamiya, Shuichiro Fujiwara, Akira Suda, Hisashi Kida, Toru Amagai, Naoya Sugiyama, Yoshinori Watanabe, Yasuo Kawabata, Yasunori Sato, Mitsuhiro Sado, Hideyuki Kodama, Aiko Sato, Yoshinari Abe, Momoko Kitazawa, Shotaro Kinoshita, Shogyoku Bun, Kiichiro Nagao, Hiroaki Tomita, Taishiro Kishimoto, Kei Sakuma, Hiroshi Kimura, Takeshi Asami, Tetsufumi Kanazawa, Michitaka Funayama, Koichi Abe, and Masaru Mimura
Subjects: Telemedicine, medicine.medical_specialty, business.industry, Telepsychiatry, medicine.disease, Mental health, Clinical trial, Family medicine, Cohort, medicine, Anxiety, medicine.symptom, business, Depression (differential diagnoses), Anxiety disorder
Abstract: IntroductionThe COVID-19 pandemic has had a profound impact on the mental health of people around the world. Anxiety related to infection, stress and stigma caused by the forced changes in daily life have reportedly increased the incidence and symptoms of depression, anxiety disorder and obsessive-compulsive disorder. Under such circumstances, telepsychiatry is gaining importance and attracting a great deal of attention. However, few large pragmatic clinical trials on the use of telepsychiatry targeting multiple psychiatric disorders have been conducted to date.MethodsThe targeted study cohort will consist of adults (>18 years) who meet the DSM-5 diagnostic criteria for either (1) depressive disorders, (2) anxiety disorders, or (3) obsessive-compulsive and related disorders. Patients will be assigned in a 1:1 ratio to either a “telepsychiatry group” (at least 50% of visits to be conducted using telemedicine, with at least one face-to-face treatment [FTF] every six months) or an “FTF group” (all visits to be conducted FTF, with no telemedicine). Both groups will receive the usual treatment covered by public medical insurance. The study will utilize a master protocol design in that there will be primary and secondary outcomes for the entire group regardless of diagnosis, as well as the outcomes for each individual disorder group.DiscussionThis study will be a non-inferiority trial to test that the treatment effect of telepsychiatry is not inferior to that of FTF alone. This study will provide useful insights into the effect of the COVID-19 pandemic on the practice of psychiatry.Trial RegistrationjRCT1030210037, Japan Registry of Clinical Trials (jRCT)
Published: 2021

25. Investigation of Physical and Chemical Characteristics of Radioactive Aerosols Emitted From Reactor Unit 1 by Fukushima Daiichi Nuclear Power Plant Accident

Author: Keisuke Sueki, Yoshinari Abe, Hisashi Nakamura, Izumi Nakai, Mitsuru Ebihara, Yuichi Moriguchi, Seika Onozaki, Takafumi Miyasaka, Kouji Adachi, Yasuhito Igarashi, Haruo Tsuruta, and Yasuji Oura
Subjects: Fukushima daiichi, Waste management, law, Nuclear power plant, Radioactive waste, Environmental science, Analytical Chemistry, law.invention
Published: 2019

26. Development of a Portable Ultraviolet-visible Absorption/Fluorescence Spectrometer and Its Application to Nondestructive On-site Analysis of Original Drawings by Katsushika Hokusai

Author: Yoshinari Abe, Susumu Shimoyama, Madoka Murakushi, Izumi Nakai, Saki Akagi, Arisa Izumi, and Airi Hirayama
Subjects: Materials science, Analytical chemistry, medicine, Fluorescence spectrometer, medicine.disease_cause, Absorption (electromagnetic radiation), Fluorescence spectroscopy, Ultraviolet, Analytical Chemistry
Published: 2019

27. Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters

Author: Jonathan P. Shock, Erika L. Nurmi, Francesco Benedetti, Gianfranco Spalletta, Anthony C. James, Damiaan Denys, Jose C. Pariente, Ignacio Martínez-Zalacaín, Yanni Liu, Paulo Marques, Joseph O'Neill, Ganesan Venkatasubramanian, Benjamin A. Ely, Noam Soreni, Tobias U. Hauser, Michael C. Stevens, Masaru Kuno, Kate D. Fitzgerald, Je-Yeon Yun, Stephanie H. Ameis, John Piacentini, Yuki Sakai, Kang Ik K. Cho, Kathrin Koch, Luciano Minuzzi, Fabrizio Piras, Hao Hu, Chaim Huyser, Philip R. Szeszko, Gerd Kvale, Zhen Wang, Luke Taylor, Jean Paul Fouche, Marcelo Q. Hoexter, Francesca Assogna, Odile A. van den Heuvel, Rachel Marsh, Carles Soriano-Mas, Alan Anticevic, David Mataix-Cols, Eiji Shimizu, Fern Jaspers-Fayer, Rajat M. Thomas, Yoshinari Abe, Pedro Moreira, Norbert Kathmann, Astrid Morer, Rosa Calvo, Guido van Wingen, João Ricardo Sato, Egill A. Fridgeirsson, Chris Perriello, Janardhanan C. Narayanaswamy, Anushree Bose, Pedro Morgado, Oana G. Rus-Oswald, Akiko Nakagawa, Silvia Brem, Luisa Lazaro, Dan J. Stein, Paul D. Arnold, Yoshiyuki Hirano, Premika S.W. Boedhoe, Emily R. Stern, Irene Bollettini, Sara Dallaspezia, Lianne Schmaal, Federica Piras, Willem B Bruin, José M. Menchón, Jan K. Buitelaar, Christian Kaufmann, Christine Lochner, Yuqi Cheng, Brian P. Brennan, H. Blair Simpson, David F. Tolin, Daan van Rooij, Pino Alonso, Iliyan Ivanov, S. Evelyn Stewart, Paul M. Thompson, Takashi Nakamae, Deniz A. Gürsel, Paul Zhutovsky, Jan C. Beucke, Jamie D. Feusner, Patricia Gruner, Tomohiro Nakao, Y.C. Janardhan Reddy, Jun Soo Kwon, Graduate School, ANS - Compulsivity, Impulsivity & Attention, APH - Global Health, APH - Mental Health, Adult Psychiatry, Child Psychiatry, Bruin, Willem B., Taylor, Luke, Thomas, Rajat M., P Shock, Jonathan, Zhutovsky, Paul, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H., Anticevic, Alan, Arnold, Paul D., Assogna, Francesca, Benedetti, Francesco, Beucke, Jan C., Boedhoe, Premika S. W., Bollettini, Irene, Bose, Anushree, Brem, Silvia, Brennan, Brian P., K Buitelaar, Jan, Calvo, Rosa, Cheng, Yuqi, Cho, Kang Ik K., Dallaspezia, Sara, Denys, Damiaan, Ely, Benjamin A., Feusner, Jamie D., Fitzgerald, Kate D., Fouche, Jean-Paul, Fridgeirsson, Egill A., Gruner, Patricia, Gürsel, Deniz A., Hauser, Tobias U., Hirano, Yoshiyuki, Hoexter, Marcelo Q., Hu, Hao, Huyser, Chaim, Ivanov, Iliyan, James, Anthony, Jaspers-Fayer, Fern, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Kuno, Masaru, Kvale, Gerd, Soo Kwon, Jun, Liu, Yanni, Lochner, Christine, Lázaro, Luisa, Marques, Paulo, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José M., Minuzzi, Luciano, Moreira, Pedro S., Morer, Astrid, Morgado, Pedro, Nakagawa, Akiko, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C., Nurmi, Erika L., O’Neill, Joseph, Pariente, Jose C., Perriello, Chri, Piacentini, John, Piras, Fabrizio, Piras, Federica, Janardhan Reddy, Y. C., Rus-Oswald, Oana G., Sakai, Yuki, Sato, João R., Schmaal, Lianne, Shimizu, Eiji, Blair Simpson, H., Soreni, Noam, Soriano-Mas, Carle, Spalletta, Gianfranco, Stern, Emily R., Stevens, Michael C., Evelyn Stewart, S., Szeszko, Philip R., Tolin, David F., Venkatasubramanian, Ganesan, Wang, Zhen, Yun, Je-Yeon, van Rooij, Daan, Consortium, ENIGMA-OCD, Thompson, Paul M., van den Heuvel, Odile A., Stein, Dan J., van Wingen, Guido A., Netherlands Institute for Neuroscience (NIN), ENIGMA-OCD Working Group, Anatomy and neurosciences, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, and Psychiatry
Subjects: Obsessive-Compulsive Disorder, Multivariate analysis, Disease, Neuroimaging biomarkers, 0302 clinical medicine, Obsessive-compulsive disorder, Medicine, Psychology, Prefrontal cortex, screening and diagnosis, medicine.diagnostic_test, Biochemical markers, Brain, Serious Mental Illness, Magnetic Resonance Imaging, 3. Good health, Psychiatry and Mental health, Detection, Mental Health, Marcadors bioquímics, Public Health and Health Services, Biomedical Imaging, Clinical psychology, medicine.drug, medicine.medical_specialty, Clinical Sciences, MEDLINE, Neuroimaging, Article, lcsh:RC321-571, Cellular and Molecular Neuroscience, 03 medical and health sciences, Obsessive compulsive, Clinical Research, Internal medicine, Medical imaging, Diagnostic biomarker, Humans, Clinical significance, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Biological Psychiatry, Fluoxetine, business.industry, Neurosi obsessiva, Neurosciences, Magnetic resonance imaging, Diagnostic markers, 030227 psychiatry, Brain Disorders, 4.1 Discovery and preclinical testing of markers and technologies, Obsessive compulsive disorder, ENIGMA-OCD Working Group, business, 030217 neurology & neurosurgery, Biomarkers, Neuroscience
Abstract: ObjectiveNo diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Magnetic resonance imaging (MRI) studies have provided evidence for structural abnormalities in distinct brain regions, but effect sizes are small and have limited clinical relevance. To investigate whether individual patients can be distinguished from healthy controls, we performed multivariate analysis of structural neuroimaging data from the ENIGMA-OCD consortium.MethodWe included 46 data sets with neuroimaging and clinical data from adult (≥18 years) and pediatric (1images from 2,304 OCD patients and 2,068 healthy controls were analyzed using standardized processing to extract regional measures of cortical thickness, surface area and subcortical volume. Machine learning classification performance was tested using cross-validation, and possible effects of clinical variables were investigated by stratification.ResultsClassification performance for OCD versus controls using the complete sample with different classifiers and cross-validation strategies was poor (AUC—0.57 (standard deviation (SD)=0.02;Pcorr=0.19) to 0.62 (SD=0.03;Pcorrcorr>.99) to 0.54 (SD=0.08;Pcorr>.99)). In contrast, good classification performance (>0.8 AUC) was achieved within subgroups of patients split according to their medication status.ConclusionsParcellated structural MRI data do not enable good distinction between patients with OCD and controls. However, classifying subgroups of patients based on medication status enables good identification at the individual subject level. This underlines the need for longitudinal studies on the short- and long-term effects of medication on brain structure.
Published: 2020

28. Duration of untreated illness of patients with obsessive-compulsive disorder in Japan

Author: Yoshihiro Matsumoto, Anri Watanabe, Jin Narumoto, Takashi Nakamae, and Yoshinari Abe
Subjects: medicine.medical_specialty, Obsessive-Compulsive Disorder, Specialty, Severe disease, Comorbidity, Affect (psychology), 03 medical and health sciences, 0302 clinical medicine, Japan, Obsessive compulsive, Drop out, Surveys and Questionnaires, mental disorders, Medicine, Outpatient clinic, Humans, Psychiatry, Biological Psychiatry, business.industry, Significant difference, Mental health, 030227 psychiatry, Diagnostic and Statistical Manual of Mental Disorders, Psychiatry and Mental health, Pshychiatric Mental Health, business, 030217 neurology & neurosurgery
Abstract: Aim Obsessive-compulsive disorder (OCD) is a common and severe disease; however, the duration of untreated illness (DUI) of OCD is approximately 7 years, which is longer than that of other psychiatric disorders. Differences in medical environments have been reported to affect the DUI. Therefore, we surveyed the DUI of OCD in Japan and the reason for delayed treatment. Methods The study participants were outpatients who visited the OCD specialty outpatient clinic for the first time between June 1, 2017 and May 31, 2019. Obsessive-compulsive disorder was diagnosed using the criteria in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, and semistructured clinical interviews, which included asking the reason for the delay in seeking treatment and treatment drop-out history. Results Seventy-one patients met the inclusion criteria for the study. The mean period between OCD and the first visit to the hospital was 2.8 years and the mean DUI of OCD was 4.7 years. There was a significant difference in the history of tic disorders and treatment drop out between patients with a DUI of >2 years and those with a DUI of ≤2 years. The most common reason for delaying treatment was that the patient did not consider the symptoms of OCD to be those of an illness, and the most common reason for dropping out of treatment was lack of improvement. Conclusions This was the first study on the DUI of OCD in Japan. The DUI was relatively shorter than that found by studies in other countries. Stopping treatment lengthened the duration of the illness. Preventing the patient from dropping out of treatment could further shorten the duration of the illness.
Published: 2020

29. Subcortical brain volume, regional cortical thickness, and cortical surface area across disorders:Findings from the ENIGMA ADHD, ASD, and OCD working groups

Author: Pedro Moreira, Ruth O'Gorman Tuura, Mara Cercignani, Philip Aherson, Maria Jalbrzikowski, Kate D. Fitzgerald, Declan G. Murphy, Bernd Kardatzki, Christine Ecker, David F. Tolin, Fern Jaspers-Fayer, Pedro Morgado, Juan Carlos Soliva Vila, Kang Ik K. Cho, Kathrin Koch, Timothy J. Silk, Philip R. Szeszko, Thomas Frodl, Mara Parellada, Shlomi Haar, Eileen Daly, Bob Oranje, Anouk Schrantee, Leyla Namazova-Baranova, Joseph A. King, Beatriz Luna, Silvia Brem, Eric Earl, Alasdair Vance, Michela Tosetti, Christine Deruelle, Ramona Baur-Streubel, Jackie Fitzgerald, Kirsten O'Hearn, Michael C. Stevens, Yoshiyuki Hirano, J. Antoni Ramos-Quiroga, Erika L. Nurmi, Kaylita Chantiluke, Joseph O'Neill, Kerstin Kohls, Olga Puig, Devon Shook, Clodagh M. Murphy, Gustavo Sudre, Marlene Behrmann, Jaap Oosterlaan, Tinatin Gogberashvili, Lianne Schmaal, Carles Soriano-Mas, Liesbeth Hoekstra, Ignacio Martínez-Zalacaín, Noam Soreni, Marcel P. Zwiers, Paulo Mattos, Gregor Kohls, Andreas J. Fallgatter, Tiffany M. Chaim-Avancini, Alexander Baranov, S. Evelyn Stewart, Sara Dallaspezia, Gianfranco Spalletta, Jonna Kuntsi, Lizanne J. S. Schweren, Joel T. Nigg, Leanne Tamm, Premika S.W. Boedhoe, Adriana Di Martino, Jane McGrath, Marcelo C. Batistuzzo, Norbert Skokauskas, Filippo Muratori, John Piacentini, Jean-Paul Fouche, Sarah Baumeister, Alan Anticevic, Neil A. Harrison, Christine M. Freitag, Pedro G.P. Rosa, Stephen V. Faraone, Ana Cubillo, David Mataix-Cols, Yuki Sakai, Stefan Ehrlich, Eileen Oberwelland Weiss, Fabrizio Piras, Dirk J. Heslenfeld, Je-Yeon Yun, Paul Pauli, Catharina A. Hartman, Ganesan Venkatasubramanian, Janardhanan C. Narayanaswamy, Charles B Malpas, Jan C. Beucke, José M. Menchón, Egill A. Fridgeirsson, Margot J. Taylor, Mauricio Moller Martinho, H. Blair Simpson, Jan K. Buitelaar, Gerd Kvale, Ivanei E. Bramati, Aki Tsuchiyagaito, Susanne Walitza, Irene Bollettini, Jeffery N. Epstein, Anders M. Dale, Thomas Ethofer, Terry L. Jernigan, David Coghill, Rachel Marsh, Andreas Reif, Astri J. Lundervold, Pieter J. Hoekstra, Oana Georgiana Rus, Damiaan Denys, Gregory L. Wallace, Matt C. Gabel, Hazel McCarthy, Sarah Hohmann, Rosa Nicolau, Stephanie H. Ameis, Neda Jahanshad, Takashi Nakamae, Xin Feng, Emily R. Stern, Georg G. von Polier, Yanni Liu, Paulo Marques, Anushree Bose, Hao Hu, Sara Lera-Miguel, Deniz A. Gürsel, Jochen Seitz, Jos W. R. Twisk, Mario Rodrigues Louzã, Clare Kelly, Annette Conzelmann, Alysa E. Doyle, Odile A. van den Heuvel, Anthony A. James, Chris Perriello, Joost Janssen, Damien A. Fair, Norbert Kathmann, Francisco X. Castellanos, Paul D. Arnold, Oscar Vilarroya, Geraldo F. Busatto, Federica Piras, Pino Alonso, Akiko Nakagawa, Sarah Durston, Lena Schwarz, Mitul A. Mehta, Dan J. Stein, Celso Arango, Daan van Rooij, Ilan Dinstein, Anastasia Christakou, Klaus-Peter Lesch, Kerstin J. Plessen, Jennifer Fedor, Yolanda Vives-Gilabert, Ilaria Gori, Louise Gallagher, Brian P. Brennan, Yuqi Cheng, Barbara Franke, Sabin Khadka, Stephanie E. Novotny, Martine Hoogman, Georgii Karkashadze, Georg C. Ziegler, Yuliya N. Yoncheva, Rosa Calvo, Thomas Wolfers, Marcelo Q. Hoexter, Benjamin A. Ely, Masaru Kuno, Alessandra Retico, Yoshinari Abe, Geoffrey B. Hall, Tobias Banaschewski, Anatoly Anikin, Christine Lochner, Astrid Morer, Guido van Wingen, Jan Haavik, Joseph Biederman, Luisa Lázaro, Francesco Benedetti, Fengfeng Zhou, Guillaume Auzias, Daniel Brandeis, Dmitry Kapilushniy, Katya Rubia, Philip Shaw, Christian Kaufmann, Sara Calderoni, Marcus V. Zanetti, Anastasia Solovieva, Zhen Wang, Francesca Assogna, Jamie D. Feusner, Chaim Huyser, Fernanda Tovar-Moll, Theo G.M. van Erp, Y.C. Janardhan Reddy, Jun Soo Kwon, Yannis Paloyelis, Anna Calvo, Patricia Gruner, Kathrin C. Zierhut, Liesbeth Reneman, Tomohiro Nakao, Janita Bralten, Marie F. Høvik, Mark A. Bellgrove, Maarten Mennes, Paul M. Thompson, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Epidemiology and Data Science, Pediatric surgery, Radiology and nuclear medicine, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Psychiatry, APH - Methodology, APH - Health Behaviors & Chronic Diseases, Boedhoe, Premika S W, van Rooij, Daan, Hoogman, Martine, Twisk, Jos W R, Schmaal, Lianne, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H, Anikin, Anatoly, Anticevic, Alan, Arango, Celso, Arnold, Paul D, Asherson, Philip, Assogna, Francesca, Auzias, Guillaume, Banaschewski, Tobia, Baranov, Alexander, Batistuzzo, Marcelo C, Baumeister, Sarah, Baur-Streubel, Ramona, Behrmann, Marlene, Bellgrove, Mark A, Benedetti, Francesco, Beucke, Jan C, Biederman, Joseph, Bollettini, Irene, Bose, Anushree, Bralten, Janita, Bramati, Ivanei E, Brandeis, Daniel, Brem, Silvia, Brennan, Brian P, Busatto, Geraldo F, Calderoni, Sara, Calvo, Anna, Calvo, Rosa, Castellanos, Francisco X, Cercignani, Mara, Chaim-Avancini, Tiffany M, Chantiluke, Kaylita C, Cheng, Yuqi, Cho, Kang Ik K, Christakou, Anastasia, Coghill, David, Conzelmann, Annette, Cubillo, Ana I, Dale, Anders M, Dallaspezia, Sara, Daly, Eileen, Denys, Damiaan, Deruelle, Christine, Di Martino, Adriana, Dinstein, Ilan, Doyle, Alysa E, Durston, Sarah, Earl, Eric A, Ecker, Christine, Ehrlich, Stefan, Ely, Benjamin A, Epstein, Jeffrey N, Ethofer, Thoma, Fair, Damien A, Fallgatter, Andreas J, Faraone, Stephen V, Fedor, Jennifer, Feng, Xin, Feusner, Jamie D, Fitzgerald, Jackie, Fitzgerald, Kate D, Fouche, Jean-Paul, Freitag, Christine M, Fridgeirsson, Egill A, Frodl, Thoma, Gabel, Matt C, Gallagher, Louise, Gogberashvili, Tinatin, Gori, Ilaria, Gruner, Patricia, Gürsel, Deniz A, Haar, Shlomi, Haavik, Jan, Hall, Geoffrey B, Harrison, Neil A, Hartman, Catharina A, Heslenfeld, Dirk J, Hirano, Yoshiyuki, Hoekstra, Pieter J, Hoexter, Marcelo Q, Hohmann, Sarah, Høvik, Marie F, Hu, Hao, Huyser, Chaim, Jahanshad, Neda, Jalbrzikowski, Maria, James, Anthony, Janssen, Joost, Jaspers-Fayer, Fern, Jernigan, Terry L, Kapilushniy, Dmitry, Kardatzki, Bernd, Karkashadze, Georgii, Kathmann, Norbert, Kaufmann, Christian, Kelly, Clare, Khadka, Sabin, King, Joseph A, Koch, Kathrin, Kohls, Gregor, Konrad, Kerstin, Kuno, Masaru, Kuntsi, Jonna, Kvale, Gerd, Kwon, Jun Soo, Lázaro, Luisa, Lera-Miguel, Sara, Lesch, Klaus-Peter, Hoekstra, Liesbeth, Liu, Yanni, Lochner, Christine, Louza, Mario R, Luna, Beatriz, Lundervold, Astri J, Malpas, Charles B, Marques, Paulo, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mattos, Paulo, Mccarthy, Hazel, Mcgrath, Jane, Mehta, Mitul A, Menchón, José M, Mennes, Maarten, Martinho, Mauricio Moller, Moreira, Pedro S, Morer, Astrid, Morgado, Pedro, Muratori, Filippo, Murphy, Clodagh M, Murphy, Declan G M, Nakagawa, Akiko, Nakamae, Takashi, Nakao, Tomohiro, Namazova-Baranova, Leyla, Narayanaswamy, Janardhanan C, Nicolau, Rosa, Nigg, Joel T, Novotny, Stephanie E, Nurmi, Erika L, Weiss, Eileen Oberwelland, O'Gorman Tuura, Ruth L, O'Hearn, Kirsten, O'Neill, Joseph, Oosterlaan, Jaap, Oranje, Bob, Paloyelis, Yanni, Parellada, Mara, Pauli, Paul, Perriello, Chri, Piacentini, John, Piras, Fabrizio, Piras, Federica, Plessen, Kerstin J, Puig, Olga, Ramos-Quiroga, J Antoni, Reddy, Y C Janardhan, Reif, Andrea, Reneman, Liesbeth, Retico, Alessandra, Rosa, Pedro G P, Rubia, Katya, Rus, Oana Georgiana, Sakai, Yuki, Schrantee, Anouk, Schwarz, Lena, Schweren, Lizanne J S, Seitz, Jochen, Shaw, Philip, Shook, Devon, Silk, Tim J, Simpson, H Blair, Skokauskas, Norbert, Soliva Vila, Juan Carlo, Solovieva, Anastasia, Soreni, Noam, Soriano-Mas, Carle, Spalletta, Gianfranco, Stern, Emily R, Stevens, Michael C, Stewart, S Evelyn, Sudre, Gustavo, Szeszko, Philip R, Tamm, Leanne, Taylor, Margot J, Tolin, David F, Tosetti, Michela, Tovar-Moll, Fernanda, Tsuchiyagaito, Aki, van Erp, Theo G M, van Wingen, Guido A, Vance, Alasdair, Venkatasubramanian, Ganesan, Vilarroya, Oscar, Vives-Gilabert, Yolanda, von Polier, Georg G, Walitza, Susanne, Wallace, Gregory L, Wang, Zhen, Wolfers, Thoma, Yoncheva, Yuliya N, Yun, Je-Yeon, Zanetti, Marcus V, Zhou, Fengfeng, Ziegler, Georg C, Zierhut, Kathrin C, Zwiers, Marcel P, Thompson, Paul M, Stein, Dan J, Buitelaar, Jan, Franke, Barbara, van den Heuvel, Odile A, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Adult Psychiatry, ANS - Compulsivity, Impulsivity & Attention, Graduate School, Child Psychiatry, General Paediatrics, ARD - Amsterdam Reproduction and Development, Radiology and Nuclear Medicine, APH - Personalized Medicine, and APH - Mental Health
Subjects: Male, Research Report, Obsessive-Compulsive Disorder, Frontal cortex, Systems Analysis, Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder, [SDV]Life Sciences [q-bio], Hippocampal formation, Audiology, 0302 clinical medicine, 130 000 Cognitive Neurology & Memory, Child, Obsessive-compulsive disorder (OCD), ComputingMilieux_MISCELLANEOUS, Intelligence quotient, Psychopathology, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, ABNORMALITIES, ENIGMA, Organ Size, 3. Good health, Psychiatry and Mental health, Autism spectrum disorder, Brain size, Cohort, Female, MRI, Adult, medicine.medical_specialty, CORTEX, Adolescent, DEFICIT HYPERACTIVITY DISORDER, Human Development, Neuroimaging, behavioral disciplines and activities, Article, 03 medical and health sciences, FIELD-STRENGTH, mental disorders, medicine, MEGA-ANALYSIS, Attention deficit hyperactivity disorder, Humans, Cortical surface, Structural MRI, Attention Deficit Disorder with Hyperactivity, Cerebrum, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], business.industry, medicine.disease, 030227 psychiatry, VOXEL, Autism, business, 030217 neurology & neurosurgery
Abstract: ObjectiveAttention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. We aimed to directly compare all three disorders. The ENIGMA consortium is ideally positioned to investigate structural brain alterations across these disorders.MethodsStructural T1-weighted whole-brain MRI of controls (n=5,827) and patients with ADHD (n=2,271), ASD (n=1,777), and OCD (n=2,323) from 151 cohorts worldwide were analyzed using standardized processing protocols. We examined subcortical volume, cortical thickness and surface area differences within a mega-analytical framework, pooling measures extracted from each cohort. Analyses were performed separately for children, adolescents, and adults using linear mixed-effects models adjusting for age, sex and site (and ICV for subcortical and surface area measures).ResultsWe found no shared alterations among all three disorders, while shared alterations between any two disorders did not survive multiple comparisons correction. Children with ADHD compared to those with OCD had smaller hippocampal volumes, possibly influenced by IQ. Children and adolescents with ADHD also had smaller ICV than controls and those with OCD or ASD. Adults with ASD showed thicker frontal cortices compared to adult controls and other clinical groups. No OCD-specific alterations across different age-groups and surface area alterations among all disorders in childhood and adulthood were observed.ConclusionOur findings suggest robust but subtle alterations across different age-groups among ADHD, ASD, and OCD. ADHD-specific ICV and hippocampal alterations in children and adolescents, and ASD-specific cortical thickness alterations in the frontal cortex in adults support previous work emphasizing neurodevelopmental alterations in these disorders.
Published: 2020

30. Memory Trace Imbalance in Reinforcement and Punishment Systems Can Reinforce Implicit Choices Leading to Obsessive-Compulsive Behavior

Author: Yutaka Sakai, Yoshinari Abe, Jin Narumoto, Yuki Sakai, and Saori C. Tanaka
Subjects: Obsessive-Compulsive Disorder, Punishment (psychology), Healthy population, Engram, nobody, General Biochemistry, Genetics and Molecular Biology, Cognition, Punishment, Compulsive Behavior, medicine, Humans, Reinforcement learning, Anxiety, medicine.symptom, Reinforcement, Psychology, Reinforcement, Psychology, Cognitive psychology, TRACE (psycholinguistics)
Abstract: SummaryWe may view most of our daily activities as rational action selections; however, we sometimes reinforce maladaptive behaviors despite having explicit environmental knowledge. In this study, we model obsessive-compulsive disorder (OCD) symptoms as implicitly learned maladaptive behaviors. Simulations in the reinforcement learning framework show that agents implicitly learn to respond to intrusive thoughts when the memory trace signal for past actions decays differently for positive and negative prediction errors. Moreover, this model extends our understanding of therapeutic effects of behavioral therapy in OCD. Using empirical data, we confirm that patients with OCD show extremely imbalanced traces, which are normalized by serotonin enhancers. We find that healthy participants also vary in their obsessive-compulsive tendencies, consistent with the degree of imbalanced traces. These behavioral characteristics can be generalized to variations in the healthy population beyond the spectrum of clinical phenotypes.
Published: 2020

31. Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium

Author: Xiang-Zhen Kong, Premika S.W. Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Paul D. Arnold, Francesca Assogna, Justin T. Baker, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Brian P. Brennan, Jan Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Sara Dallaspezia, Damiaan Denys, Benjamin A. Ely, Jamie Feusner, Kate D. Fitzgerald, Jean-Paul Fouche, Egill A. Fridgeirsson, David C. Glahn, Patricia Gruner, Deniz A. Gürsel, Tobias U. Hauser, Yoshiyuki Hirano, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Anthony James, Fern Jaspers-Fayer, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Masaru Kuno, Gerd Kvale, Jun Soo Kwon, Luisa Lazaro, Yanni Liu, Christine Lochner, Paulo Marques, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, Sarah E. Medland, José M. Menchón, Luciano Minuzzi, Pedro S. Moreira, Astrid Morer, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Joseph O'Neill, Jose C. Pariente, Chris Perriello, John Piacentini, Fabrizio Piras, Federica Piras, Christopher Pittenger, Y.C. Janardhan Reddy, Oana Georgiana Rus-Oswald, Yuki Sakai, Joao R. Sato, Lianne Schmaal, H. Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Emily R. Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, David F. Tolin, Aki Tsuchiyagaito, Daan van Rooij, Guido A. van Wingen, Ganesan Venkatasubramanian, Zhen Wang, Je-Yeon Yun, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Clyde Francks, Alan Anticevic, Nerisa Banaj, Nuria Bargalló, Daniel Brandeis, Geraldo F. Busatto, Anna Calvo, Valentina Ciullo, Froukje E. de Vries, Stella J. de Wit, Erin Dickie, Renate Drechsler, Madalena Esteves, Andrea Falini, Yu Fang, Martijn Figee, Martine Fontaine, Geoff Hall, Sayo Hamatani, Gregory L. Hanna, Bjarne Hansen, Keisuke Ikari, Neda Jahanshad, Ricardo Magalhães, Yasutaka Masuda, Koji Matsumoto, James T. McCracken, Euripedes C. Miguel, Jin Narumoto, Seiji Nishida, Sara Poletti, Tim Reess, Eiji Shimizu, Nuno Sousa, Jumpei Takahashi, Jinsong Tang, Anders Lillevik Thorsen, Ysbrand D. van der Werf, Dick J. Veltman, Daniela Vecchio, Susanne Walitza, Anri Watanabe, Jian Xu, Xiufeng Xu, Kei Yamada, Tokiko Yoshida, Mojtaba Zarei, Qing Zhao, Cong Zhou, ENIGMA-OCD Working Group, Adult Psychiatry, ANS - Compulsivity, Impulsivity & Attention, Graduate School, Child Psychiatry, Kong, X. -Z., Boedhoe, P. S. W., Abe, Y., Alonso, P., Ameis, S. H., Arnold, P. D., Assogna, F., Baker, J. T., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., Bollettini, I., Bose, A., Brem, S., Brennan, B. P., Buitelaar, J., Calvo, R., Cheng, Y., Cho, K. I. K., Dallaspezia, S., Denys, D., Ely, B. A., Feusner, J., Fitzgerald, K. D., Fouche, J. -P., Fridgeirsson, E. A., Glahn, D. C., Gruner, P., Gursel, D. A., Hauser, T. U., Hirano, Y., Hoexter, M. Q., Hu, H., Huyser, C., James, A., Jaspers-Fayer, F., Kathmann, N., Kaufmann, C., Koch, K., Kuno, M., Kvale, G., Kwon, J. S., Lazaro, L., Liu, Y., Lochner, C., Marques, P., Marsh, R., Martinez-Zalacain, I., Mataix-Cols, D., Medland, S. E., Menchon, J. M., Minuzzi, L., Moreira, P. S., Morer, A., Morgado, P., Nakagawa, A., Nakamae, T., Nakao, T., Narayanaswamy, J. C., Nurmi, E. L., O'Neill, J., Pariente, J. C., Perriello, C., Piacentini, J., Piras, F., Pittenger, C., Reddy, Y. C. J., Rus-Oswald, O. G., Sakai, Y., Sato, J. R., Schmaal, L., Simpson, H. B., Soreni, N., Soriano-Mas, C., Spalletta, G., Stern, E. R., Stevens, M. C., Stewart, S. E., Szeszko, P. R., Tolin, D. F., Tsuchiyagaito, A., van Rooij, D., van Wingen, G. A., Venkatasubramanian, G., Wang, Z., Yun, J. -Y., Anticevic, A., Banaj, N., Bargallo, N., Brandeis, D., Busatto, G. F., Calvo, A., Ciullo, V., de Vries, F. E., de Wit, S. J., Dickie, E., Drechsler, R., Esteves, M., Falini, A., Fang, Y., Figee, M., Fontaine, M., Hall, G., Hamatani, S., Hanna, G. L., Hansen, B., Ikari, K., Jahanshad, N., Magalhaes, R., Masuda, Y., Matsumoto, K., Mccracken, J. T., Miguel, E. C., Narumoto, J., Nishida, S., Poletti, S., Reess, T., Shimizu, E., Sousa, N., Takahashi, J., Tang, J., Thorsen, A. L., van der Werf, Y. D., Veltman, D. J., Vecchio, D., Walitza, S., Watanabe, A., Xu, J., Xu, X., Yamada, K., Yoshida, T., Zarei, M., Zhao, Q., Zhou, C., Thompson, P. M., Stein, D. J., van den Heuvel, O. A., Francks, C., Netherlands Institute for Neuroscience (NIN), Universidade do Minho, Anatomy and neurosciences, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, and Psychiatry
Subjects: 0301 basic medicine, Adult, medicine.medical_specialty, Obsessive-Compulsive Disorder, Mega-analysis, Mega-analysi, media_common.quotation_subject, Thalamus, Medicina Básica [Ciências Médicas], Audiology, Asymmetry, behavioral disciplines and activities, 03 medical and health sciences, 0302 clinical medicine, Neuroimaging, mental disorders, medicine, Image Processing, Computer-Assisted, Obsessive-compulsive disorder, Brain asymmetry, Humans, Child, Biological Psychiatry, Depression (differential diagnoses), media_common, Brain Mapping, Science & Technology, medicine.diagnostic_test, business.industry, Laterality, Neurosi obsessiva, Brain, Magnetic resonance imaging, Cerebral cortex, Magnetic Resonance Imaging, humanities, Escorça cerebral, 030104 developmental biology, Meta-analysis, Ciências Médicas::Medicina Básica, Pallidum, Anxiety, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract: Accepted Manuscript, BACKGROUND: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD.METHODS: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status.RESULTS: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = -20.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets.CONCLUSIONS: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD., This research was funded by the Max Planck Society (Germany). Additional funding was from the Japan Society for the Promotion of Science (KAKENHI Grant No. 18K15523 [to YA], KAKENHI Grant No. 16K04344 [to YH], KAKENHI Grant Nos. 16K19778 and 18K07608 [to TNakam], and KAKENHI Grant No. 26461762 [to AN]); the Carlos III Health Institute (Grant No. PI14/00419 [to PA], Grant No. PI040829 cofunded by European Regional Development Fund [to LL], Grant No. FI17/00294 [to IM-Z], Grant No. PI16/00950 [to JMM], and Grant Nos. CPII16/00048, PI13/01958, and PI16/00889 cofunded by European Regional Development Funds [to CS-M]); the Ontario Mental Health Foundation (Research Training Fellowship [to SHA]); Alberta Innovates Translational Health Chair in Child and Youth Mental Health (to PDA), the Ontario Brain Institute (to PDA); the National Institute of Mental Health (Grant No. K23MH104515 [to JTB], Grant No. K23-MH092397 [to BPB], Grant No. K23MH082176 [to KDF), Grant No. R21MH101441 [to RM], Grant No. R01MH081864 [to JO and JP], and Grant No. R01MH085900 [to JO and JF], Grant No. R21MH093889 [to HBS]); Fundação de Amparo à Pesquisa do Estado de São Paulo (Grant No. 2011/21357–9 [to MCB], Grant No. 2011/21357–9 [to GFB], Grant No. 2011/21357–9 [to MQH], and Grant No. 2011/21357–9 [to ECM]); the Swiss National Science Foundation (Grant No. 320030_130237 [to SB; principal investigator, Susanne Walitza]); the Hartmann Müller Foundation (Grant No. 1460 [to SB]); the David Judah Fund at the Massachusetts General Hospital (to BPB); EU FP7 Project TACTICS (Grant No. 278948 [to JB]); the National Natural Science Foundation of China (Grant No. 81560233 [to YC] and Grant No. 81371340 [to ZW]); the International OCD Foundation (Grant No. K23 MH115206 [to PG]); the Wellcome Sir Henry Dale Fellowship (Grant No. 211155/Z/18/Z [to TUH]); the Jacobs Foundation (to TUH); the Brain and Behavior Research Foundation (2018 NARSAD Young Investigator Grant No. 27023 [to TUH]); the Agency for Medical Research and Development (Grant No. JP18dm0307002 [to YH]); the Michael Smith Foundation for Health Research (to FJ-F); the Federal Ministry of Education and Research of Germany (Grant No. BMBF-01GW0724 [to NK]); the Deutsche Forschungsgemeinschaft (Grant No. KO 3744/7–1 [to KK]); the Helse Vest Health Authority (Grant Nos. 911754 and 911880 [to GK]); the Norwegian Research Council (Grant No. HELSEFORSK 243675 [to GK]); the Marató TV3 Foundation (Grant Nos. 01/2010 and 091710 [to LL]); the Agency for Management of University and Research Grants (Grant No. 2017 SGR 881 [to LL] and 2017 SGR 1247 from the Generalitat de Catalunya [to JMM]); Fundação para a Ciência e a Tecnologia (Grant No. PDE/BDE/113604/2015 from the PhD-iHES Program [to RM], Grant No. PDE/BDE/113601/2015 from the PhD-iHES Program [to PSM]); the Japanese Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid for Scientific Research (Grant Nos. 22591262, 25461732, and 16K10253 [to TNakao]); the Government of India Department of Science and Technology (DST INSPIRE Faculty Grant No. -IFA12-LSBM-26 [to JCN] and Grant No. SR/S0/HS/0016/2011 [to YCJR]); the Government of India Department of Biotechnology (Grant No. BT/06/IYBA/2012 [to JCN] and Grant No. BT/PR13334/Med/30/259/2009 [to YCJR]); the New York State Office of Mental Health (to HBS); the Italian Ministry of Health (Grant No. RC13-14-15-16A [to GS]); the National Center for Advancing Translational Sciences (Grant No. UL1TR000067/KL2TR00069 [to ERS]); the Canadian Institutes of Health Research (to SES); the Michael Smith Foundation for Health Research (to SES); the British Columbia Provincial Health Services Authority (to SES); the Netherlands Organization for Scientific Research (Grant No. NWO/ZonMW Vidi 917.15.318 [to GAvW]); the Wellcome-DBT India Alliance (Grant No. 500236/Z/11/Z [to GV]); the Shanghai Key Laboratory of Psychotic Disorders (Grant No. 13dz2260500 [to ZW]).
Published: 2020

32. Report of chemical compositional characterisation of glass fragments excavated from Dariali Fort (Georgia) by non-destructive X-ray fluorescence analysis

Author: Yoshinari Abe and Ryuji Shikaku
Published: 2020

33. Trace-element Analysis of Volcanic Glass Shards by Laser Ablation ICP-MS for Forensic Soil Analysis

Author: Izumi Nakai, Yoshinari Abe, and Teppei Nogami
Subjects: 010506 paleontology, Laser ablation, Materials science, Soil test, 010401 analytical chemistry, Mineralogy, 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, Volcanic glass, La icp ms, Trace element analysis, Inductively coupled plasma mass spectrometry, 0105 earth and related environmental sciences
Published: 2018

34. Ancient glassware travelled the Silk Road: Nondestructive X-ray fluorescence analysis of a fragment of a facet-cut glass vessel collected at Kamigamo Shrine in Kyoto, Japan

Author: Izumi Nakai, Ryuji Shikaku, Masakazu Yamamoto, Yoshinari Abe, and Naoto Yagi
Subjects: Archeology, 060102 archaeology, Fragment (computer graphics), 010401 analytical chemistry, X-ray fluorescence, 06 humanities and the arts, Glass vessel, 01 natural sciences, Archaeology, 0104 chemical sciences, SILK, Capital city, 0601 history and archaeology, Geology
Abstract: In 1964, a fragment of a colorless facet-cut glass vessel was collected at the Kamigamo Shrine, located in Kyoto, which was the capital city of Japan from late 8th century AD through the mid-19th century AD. X-ray fluorescence analytical techniques were applied to this fragment in a nondestructive manner with the aim of scientific provenancing based on its chemical compositional features. It was found that, the chemical composition of the fragment closely matched that of one compositional group in Sasanian glass which was characterized by the use of a pure silica source and magnesia-rich plant ash as the raw materials. Given the discoveries of facet-cut glassware from the region of the Sasanian Empire that are very similar to this fragment, it is concluded that the primary production and possibly subsequent production processes (i.e., secondary production and a facet-cut decoration) of this glass were carried out at the Sasanian glass workshops. This study is the second case of an investigation that has identified a specific provenance of one of the few glass vessels introduced into ancient Japan through the Silk Road.
Published: 2018

35. White Matter Microstructure and its Relation to Clinical Features of Obsessive-Compulsive Disorder: Findings from the ENIGMA OCD Working Group

Author: Marcelo C. Batistuzzo, Jan C. Beucke, Marcelo Q. Hoexter, Rachel Marsh, Stephanie H. Ameis, Jumpei Takahashi, Jun Soo Kwon, Paul D. Arnold, Silvia Brem, Yoshinari Abe, Philipp Stämpfli, Premika S.W. Boedhoe, Benjamin Adam, Núria Bargalló, Sara Dallaspezia, Anthony A. James, Anna Calvo, Yoshiyuki Hirano, Patricia Gruner, Dan J. Stein, Noam Soreni, Eiji Shimizu, Gianfranco Spalletta, Akiko Nakagawa, Kang Ik K. Cho, Kathrin Koch, Daniela Simon, Fabrizio Piras, Ganesan Venkatasubramanian, Zhen Wang, Sri Mahavir Agarwal, Yuki Sakai, Philip R. Szeszko, Irene Bollettini, Emily R. Stern, Christian Kaufmann, Siyan Fan, Jean-Paul Fouche, Federica Piras, Tobias U. Hauser, Neda Jahanshad, Christine Lochner, Paul M. Thompson, Janardhanan C. Narayanaswamy, Mariangela Iorio, Janardhan Y. C. Reddy, Alan Anticevic, Odile A. van den Heuvel, Peter Kochunov, Erin W. Dickie, Je Yeon Yun, Luisa Lázaro, Francesco Benedetti, Takashi Nakamae, Deniz A. Gürsel, and Helen Blair Simpson
Subjects: medicine.medical_specialty, business.industry, Audiology, Age and sex, White matter microstructure, White matter, medicine.anatomical_structure, Group differences, Obsessive compulsive, Fractional anisotropy, Cohort, medicine, business, Diffusion MRI
Abstract: ImportanceMicrostructural alterations in cortico-subcortical connections are thought to be present in Obsessive-Compulsive Disorder (OCD). However, prior studies have yielded inconsistent findings, perhaps because small sample sizes provided insufficient power to detect subtle abnormalities.ObjectiveTo investigate microstructural white matter alterations and their relation to clinical features in the largest dataset of adult and pediatric OCD to date.Design, Setting, and ParticipantsIn this cross-sectional case-control magnetic resonance study, we investigated diffusion tensor imaging metrics from 700 adult patients and 645 adult controls, as well as 174 pediatric patients and 144 pediatric controls across 19 sites participating in the ENIGMA-OCD Working Group.Main Outcomes and MeasuresWe extracted measures of fractional anisotropy (FA) as main outcome, and mean diffusivity, radial diffusivity, and axial diffusivity as secondary outcomes for 25 white matter regions. We meta-analyzed patient-control group differences (Cohen’s d) across sites, after adjusting for age and sex, and investigated associations with clinical characteristics.ResultsAdult OCD patients showed significant FA reduction in the sagittal stratum (d=-0.21, z=-3.21, p=0.001) and posterior thalamic radiation (d=-0.26, z=-4.57, pConclusions and RelevanceMicrostructural alterations in projection and association fibers to posterior brain regions were found in adult OCD, and related to disease course and medication status. Such results are relevant to models positing deficits in connectivity as a crucial mechanism in OCD.KEY POINTSQuestionDo patients with Obsessive-Compulsive Disorder (OCD) show white matter microstructural alterations, and are these alterations related to clinical features?FindingsData from 19 sites of the ENIGMA-OCD Consortium were included, involving 700 adult patients and 645 adult controls, 174 pediatric patients and 144 pediatric controls. Diffusion tensor imaging data were meta-analyzed using a harmonized data processing and analysis protocol. Adult, but not pediatric, patients showed alterations in the sagittal stratum and posterior thalamic radiation; sagittal stratum differences were associated with clinical features.MeaningMicrostructural abnormalities found in adult but not in the pediatric cohort, are related to illness duration and medication status.
Published: 2019
Full Text: View/download PDF

36. The detection of white matter alterations in obsessive–compulsive disorder revealed by TRActs Constrained by UnderLying Anatomy (TRACULA)

Author: Yuki Sakai, Isao Yokota, Kei Yamada, Anri Watanabe, Seiji Nishida, Takashi Nakamae, Jin Narumoto, and Yoshinari Abe
Subjects: Neuropsychiatric Disease and Treatment, business.industry, Radial diffusivity, tractography, Anatomy, Corpus callosum, behavioral disciplines and activities, forceps major, 030227 psychiatry, White matter, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Obsessive compulsive, radial diffusivity, mental disorders, Fractional anisotropy, medicine, Cingulum (brain), cingulum, business, 030217 neurology & neurosurgery, Forceps major, Original Research, Tractography
Abstract: Anri Watanabe,1 Takashi Nakamae,1 Yuki Sakai,2 Seiji Nishida,1 Yoshinari Abe,1 Kei Yamada,3 Isao Yokota,4 Jin Narumoto1 1Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2Department of Neural Computation for Decision-Making, Advanced Telecommunications Research Institute International Brain Information Communication Research Laboratory Group, Kyoto, Japan; 3Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; 4Department of Biostatistics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan Purpose: In recent years, a large number of studies have investigated obsessive–compulsive disorder (OCD) using diffusion-weighted images (DWIs) and have reported microstructural abnormalities in various regions, mainly the corpus callosum and cingulum. In the present study, we aimed to detect microstructural changes in the white matter using whole-brain tractography. Patients and methods: We obtained MRI data from 25 adult non-medicated OCD patients and 27 healthy controls. DWI data from MRI scans were analyzed by the automated probabilistic tractography method referred to as TRActs Constrained by UnderLying Anatomy (TRACULA). We investigated diffusivity parameters: fractional anisotropy, radial diffusivity (RD), axial diffusivity, and mean diffusivity in 18 major white matter tracts and examined indices to know which measurements in which fibers can predict the diagnosis of OCD. Results: Compared to healthy controls, OCD patients had significantly increased RD in the forceps major and a reduction of RD in the right cingulum angular (infracallosal) bundle. There was no correlation between these values and the clinical features. Conclusion: We found RD alterations in the forceps major and the right cingulum angular (infracallosal) bundle, which might be associated with myelination changes in the temporal and occipital regions in OCD. Our results suggest that the pathogenesis of OCD may include abonormality of myelination status in not only the fronto-striato-thalamic circuit but also the posterior and temporal regions. Keywords: tractography, radial diffusivity, forceps major, cingulum
Published: 2018

37. Ancient glassware travelled the Silk Road: Nondestructive X-ray fluorescence analysis of tiny glass fragments believed to be sampled from glassware excavated from Niizawa Senzuka Tumulus No. 126, Japan

Author: Yoshinari Abe, Izumi Nakai, and Ryuji Shikaku
Subjects: Archeology, SILK, Production area, 060102 archaeology, 010401 analytical chemistry, X-ray fluorescence, 0601 history and archaeology, 06 humanities and the arts, 01 natural sciences, Tumulus, Archaeology, Geology, 0104 chemical sciences
Abstract: X-ray fluorescence analytical techniques were applied to two pieces of glass fragments because they are believed to be sampled from two pieces of important glassware, a facet-cut bowl and a deeply-blue colored dish, excavated from Niizawa Senzuka Tumulus No.126, Nara, Japan (late 5th century). Two different provenances were estimated as primary production area for the two glass fragments. One fragment has a chemical composition being a good match with that of Sasanian glass excavated at Veh Ardasīr in central Iraq. Conversely, composition of another fragment is consistent with common blue-green colored Roman glass manufactured during the imperial period. If these glass fragments are actually identical to the ancient glassware excavated from Nara, our results can provide scientific evidence how various cultures were introduced to and accepted by ancient Japan. Concomitantly, they are also evidence of an extremely widespread Silk Road trading from the Mediterranean and West Asia to the Far East of Japan during the 1st millennium AD.
Published: 2018

38. Investigation of cadmium accumulation mechanism in hepatopancreas of Patinopecten yessoensis by synchrotron radiation X-ray absorption fine structure and synchrotron radiation X-ray fluorescence analyses

Author: Yoshinari Abe, Shingo Maruhashi, Shigetoshi Miura, Izumi Nakai, Kotaro Honda, Kenji Terada, and Yasuhiro Tomooka
Subjects: Cadmium, biology, 010401 analytical chemistry, Patinopecten yessoensis, Analytical chemistry, chemistry.chemical_element, Synchrotron radiation, X-ray fluorescence, 010501 environmental sciences, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, X-ray absorption fine structure, chemistry, Hepatopancreas, Spectroscopy, 0105 earth and related environmental sciences
Published: 2018

39. Analysis of two forms of radioactive particles emitted during the early stages of the Fukushima Dai-ichi Nuclear Power Station accident

Author: Yoshinari Abe, Shigeo Nakama, Hideki Yoshikawa, Takahiro Ono, Yukihiko Satou, Keisuke Sueki, Izumi Nakai, Kouji Adachi, Yasuhito Igarashi, Haruka Minowa, and Kimikazu Sasa
Subjects: 0301 basic medicine, Radioactive particles, business.industry, Nuclear engineering, Nondestructive analysis, 010501 environmental sciences, Nuclear power, 01 natural sciences, Nuclear facilities, 03 medical and health sciences, 030104 developmental biology, Geophysics, Geochemistry and Petrology, Environmental science, business, Isotopes of caesium, 0105 earth and related environmental sciences
Published: 2018

40. Japanese Project for Telepsychiatry Evaluation during COVID-19: Treatment Comparison Trial (J-PROTECT): Rationale, design, and methodology

Author: Kei Sakuma, Momoko Kitazawa, Yasunori Sato, Naoya Sugiyama, Yoshinori Watanabe, Yoshinari Abe, Masaru Mimura, Mitsuhiro Sado, Aiko Sato, Yasuo Kawabata, Kiichiro Nagao, Shotaro Kinoshita, Shogyoku Bun, Hiroshi Kimura, Hisashi Kida, Akitoyo Hishimoto, Taishiro Kishimoto, Hideyuki Kodama, Takashi Nakamae, Maki Takamiya, Hiroaki Tomita, Takaharu Azekawa, Takeshi Asami, Tetsufumi Kanazawa, Michitaka Funayama, Koichi Abe, Toshiaki Kikuchi, Toru Amagai, Akihiro Takamiya, Shuichiro Fujiwara, and Akira Suda
Subjects: YBOCS, Yale-Brown Obsessive Compulsive Scale, Research & Experimental Medicine, THERAPY, WAI, Working Alliance Inventory, Japan, QUALITY-OF-LIFE, Obsessive-compulsive disorder, ANXIETY, EQ-5D, EuroQol 5 Dimension, Pharmacology (medical), Pharmacology & Pharmacy, CSQ, Client Satisfaction Questionnaire, SCALE, Depression (differential diagnoses), SF-36, Medical Outcomes Study 36-Item Short-Form Health Survey, Psychiatry, jRCT, Japan Registry of Clinical Trials, Depression, General Medicine, SF-36 MCS, Medical Outcomes Study 36-Item Short-Form Health Survey Mental Component Summary, ePRO, electronic Patient-Reported Outcome, Telemedicine, Medicine, Research & Experimental, Anxiety disorder, DSM-5, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Cohort, Anxiety, medicine.symptom, Life Sciences & Biomedicine, MENTAL-HEALTH, FTF, face-to-face treatment, EDC, Electronic Data Capture, medicine.medical_specialty, COVID-19, the 2019 novel coronavirus disease, Full Length Article, Master protocol, medicine, Humans, QOL, Quality Of Life, PRECIS2, Pragmatic-Explanatory Continuum Indicator Summary-2, COLLABORATIVE CARE, HAMA, Hamilton Anxiety Rating Scale, MMRM, Mixed-effects Model for Repeated Measurements, Pandemics, Telepsychiatry, Science & Technology, SARS-CoV-2, business.industry, COVID-19, HAMD, Hamilton Depression Rating Scale, J-PROTECT, Japanese Project for Telepsychiatry Evaluation during COVID-19: Treatment Comparison Trial, medicine.disease, Mental health, Clinical trial, OCD, Obsessive–Compulsive Disorder, business
Abstract: INTRODUCTION: The COVID-19 pandemic has had a profound impact on the mental health of people around the world. Anxiety related to infection, stress and stigma caused by the forced changes in daily life have reportedly increased the incidence and symptoms of depression, anxiety disorder and obsessive-compulsive disorder. Under such circumstances, telepsychiatry is gaining importance and attracting a great deal of attention. However, few large pragmatic clinical trials on the use of telepsychiatry targeting multiple psychiatric disorders have been conducted to date. METHODS: The targeted study cohort will consist of adults (>18 years) who meet the DSM-5 diagnostic criteria for either (1) depressive disorders, (2) anxiety disorders, or (3) obsessive-compulsive and related disorders. Patients will be assigned in a 1:1 ratio to either a "telepsychiatry group" (at least 50% of treatments to be conducted using telemedicine, with at least one face-to-face treatment [FTF] within six months) or an "FTF group" (all treatments to be conducted FTF, with no telemedicine). Both groups will receive the usual treatment covered by public medical insurance. The study will utilize a master protocol design in that there will be primary and secondary outcomes for the entire group regardless of diagnosis, as well as the outcomes for each individual disorder group. DISCUSSION: This study will be a non-inferiority trial to test that the treatment effect of telepsychiatry is not inferior to that of FTF alone. This study will provide useful insights into the effect of the COVID-19 pandemic on the practice of psychiatry. TRIAL REGISTRATION: jRCT1030210037, Japan Registry of Clinical Trials (jRCT). ispartof: CONTEMPORARY CLINICAL TRIALS vol:111 ispartof: location:United States status: published
Published: 2021

41. Did ancient glassware travel the Silk Road? X-ray fluorescence analysis of a Sasanian glass vessel from Okinoshima Island, Japan

Author: Madoka Murakushi, Izumi Nakai, Ryuji Shikaku, Makiko Fukushima, and Yoshinari Abe
Subjects: Archeology, Shard, Mesopotamia, media_common.quotation_subject, X-ray fluorescence, Fluorescence spectrometer, Glass vessel, Art, Treasure, Archaeology, media_common
Abstract: The use of a portable X-ray fluorescence spectrometer revealed the provenance of a shard of a relief-cut glass bowl which was dedicated to ancient ritual on the sacred island of Okinoshima, Japan over a thousand years ago. The shard was unearthed from one of the ritual sites on the island in the 1950s and is now designated as a national treasure in Japan. A nondestructive and on-site X-ray fluorescence analytical technique was applied to the Okinoshima glass shard to establish where and when it was originally manufactured based on its chemical composition. Clear correspondence of chemical composition between the shard and glass excavated from a Sasanian city site in Mesopotamia demonstrated that the shard was derived from a type of glassware primarily produced in glass workshops within the Sasanian Empire between the fifth and seventh centuries AD. This is the first scientific evidence demonstrating that glass was imported from overseas across thousands of kilometers and then dedicated for the ritual on Okinoshima Island. This simultaneously gives us a glimpse of the specific details of divine rituals conducted on Okinoshima Island in ancient times.
Published: 2021

42. Design of all-solid-state chloride and nitrate ion-selective electrodes using anion insertion materials of electrodeposited poly(allylamine)-MnO2 composite

Author: Tatsuya Akatsuka, Yoshinari Abe, Shinichi Komaba, and Kazuhiko Tsuchiya
Subjects: Materials science, General Chemical Engineering, Potentiometric titration, Inorganic chemistry, Composite number, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Chloride, Vinyl chloride, 0104 chemical sciences, Allylamine, Ion selective electrode, chemistry.chemical_compound, Membrane, chemistry, Electrode, Electrochemistry, medicine, 0210 nano-technology, medicine.drug
Abstract: All-solid-state ion-selective electrodes as potentiometric ion sensors for the determination of chloride (Cl−) or nitrate (NO3−) ions were designed by inserting an electrodeposited composite layer consisting of manganese dioxide and poly(allylamine), a polymeric cation, as the inner solid-contact layer between the electrode substrate and poly(vinyl chloride) (PVC)-based ion-sensitive membrane containing the corresponding ionophores for Cl− or NO3− ions. The double-layered ion-selective electrodes exhibited selective and quick (≤10 s) potential response for the anions; moreover, the Nernstian slopes of the calibration curves of the electrodes were adequate, and the electrodes presented a wide detection range (10−5–10−1 mol dm−3). As the poly(allylamine)-manganese dioxide composites presented anion-insertion redox activity, the insertion of composite layers was highly effective in stabilizing the membrane potential of PVC because it lowered the impedance at the electrode interface, resulting in quicker responses to the anion activity in analytes than those of the corresponding electrodes without composite layers.
Published: 2021

43. Distinct Subcortical Volume Alterations in Pediatric and Adult OCD

Author: Federica Piras, Christine Lochner, Jan C. Beucke, José M. Menchón, Philip R. Szeszko, Hao Hu, Janardhanan C. Narayanaswamy, Damiaan Denys, Guido van Wingen, Yanni Liu, Luisa Lazaro, Jean Paul Fouche, Marcelo Queiroz Hoexter, Y. C.Janardhan Reddy, Silvia Brem, Paul D. Arnold, Sara Dallaspezia, Keisuke Ikari, Neda Jahanshad, Qing Zhao, Kang Ik Cho, Norbert Kathmann, Gianfranco Spalletta, Yuqi Cheng, Susanne Walitza, Derrek P. Hibar, Dan J. Stein, Christopher Pittenger, Odile A. van den Heuvel, Yoshinari Abe, Anushree Bose, David Mataix-Cols, Ganesan Venkatasubramanian, Je Yeon Yun, Ignacio Martínez-Zalacaín, Xiufeng Xu, João Ricardo Sato, Noam Soreni, Premika S.W. Boedhoe, Luciano Minuzzi, Carles Soriano-Mas, David F. Tolin, Kate D. Fitzgerald, Christian Kaufmann, Rachel Marsh, H. Blair Simpson, Fabrizio Piras, Zhen Wang, Michael C. Stevens, Lianne Schmaal, Marcelo C. Batistuzzo, Takashi Nakamae, Paul M. Thompson, Stephanie H. Ameis, Gregory L. Hanna, Irene Bollettini, Chaim Huyser, Kathrin Koch, Jun Soo Kwon, Mónica Giménez, Anna Calvo, Francesco Benedetti, Patricia Gruner, Jian Xu, Tomohiro Nakao, Universitat de Barcelona, Other departments, ANS - Amsterdam Neuroscience, Adult Psychiatry, Boedhoe, Premika S. W., Schmaal, Lianne, Abe, Yoshinari, Ameis, Stephanie H., Arnold, Paul D., Batistuzzo, Marcelo C., Benedetti, Francesco, Beucke, Jan C., Bollettini, Irene, Bose, Anushree, Brem, Silvia, Calvo, Anna, Cheng, Yuqi, Cho, Kang Ik, Dallaspezia, Sara, Denys, Damiaan, Fitzgerald, Kate D., Fouche, Jean-Paul, Giménez, Mònica, Gruner, Patricia, Hanna, Gregory L., Hibar, Derrek P., Hoexter, Marcelo Q., Hu, Hao, Huyser, Chaim, Ikari, Keisuke, Jahanshad, Neda, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Kwon, Jun Soo, Lazaro, Luisa, Liu, Yanni, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José M., Minuzzi, Luciano, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C., Piras, Fabrizio, Piras, Federica, Pittenger, Christopher, Reddy, Y. C. Janardhan, Sato, Joao R., Simpson, H. Blair, Soreni, Noam, Soriano-Mas, Carle, Spalletta, Gianfranco, Stevens, Michael C., Szeszko, Philip R., Tolin, David F., Venkatasubramanian, Ganesan, Walitza, Susanne, Wang, Zhen, Van Wingen, Guido A., Xu, Jian, Xu, Xiufeng, Yun, Je-Yeon, Zhao, Qing, Thompson, Paul M., Stein, Dan J., Van Den Heuvel, Odile A., Psychiatry, Anatomy and neurosciences, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, and Netherlands Institute for Neuroscience (NIN)
Subjects: Obsessive-Compulsive Disorder, FreeSurfer, Audiology, Pediatrics, Hippocampus, 0302 clinical medicine, Neurodevelopmental disorder, Thalamus, Obsessive-compulsive disorder, Young adult, Child, Psychiatry, Pediatria, medicine.diagnostic_test, Healthy subjects, Organ Size, Middle Aged, Control subjects, Magnetic Resonance Imaging, Psychiatry and Mental health, Psychiatry and Mental Health, Mega analysis, Psychology, Human, Adult, medicine.medical_specialty, Adolescent, Neuroimaging, Globus Pallidus, behavioral disciplines and activities, Article, Malalts, 03 medical and health sciences, Young Adult, Hippocampu, mental disorders, medicine, Humans, Thalamu, Sick, Neurosi obsessiva, Globus Pallidu, Magnetic resonance imaging, Voxel-based morphometry, medicine.disease, 030227 psychiatry, Structural MRI, 030217 neurology & neurosurgery
Abstract: Objective: structural brain imaging studies in obsessive compulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted meta and mega-analyses of data from OCD sites worldwide. Method: T-1 images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coordinated and standardized processing, to identify subcortical brain volumes that differ between OCD patients and healthy subjects. The authors performed a meta analysis on the mean of the left and right hemisphere measures of each subcortical structure, and they performed a mega-analysis by pooling these volumetric measurements from each site. The authors additionally examined potential modulating effects of clinical characteristics on morphological differences in OCD patients. Results: the meta-analysis indicated that adult patients had significantly smaller hippocampal volumes (Cohen's d=-0.13; % difference=-2.80) and larger pallidum volumes (d=0.16; % difference=3.16) compared with adult controls. Both effects were stronger in medicated patients compared with controls (d=-0.29, % difference=-4.18, and d=0.29, % difference=4.38, respectively). Unmedicated pediatric patients had significantly larger thalamic volumes (d=0.38, % difference=3.08) compared with pediatric controls. None of these findings were mediated by sample characteristics, such as mean age or scanning field strength. The mega-analysis yielded similar results. Conclusions: the results indicate different patterns of sub cortical abnormalities in pediatric and adult OCD patients. The patlidum and hippocampus seem to be of importance in adult OCD, whereas the thalamus seems to be key in pediatric OCD. These findings highlight the potential importance of neurodevelopmental alterations in OCD and suggest that further research on neuroplasticity in OCD may be useful.
Published: 2017

44. Characterization of Japanese Sake by Trace-element Compositions and Isotope Ratio of Light Elements

Author: Yoshinari Abe, Nami Sasamoto, Yuichi Takaku, and Izumi Nakai
Subjects: 0301 basic medicine, Strontium, Chromatography, Isotope, business.industry, Trace element, Vanadium, chemistry.chemical_element, Analytical Chemistry, Characterization (materials science), 03 medical and health sciences, 030104 developmental biology, chemistry, Brewing, Fermentation, business, Inductively coupled plasma mass spectrometry
Published: 2017

45. Construction of a Forensic Soil Database of the Hokkaido Region in Japan by Synchrotron Radiation X-ray Analysis

Author: Izumi Nakai, Masataka Hirao, Masayoshi Itou, Yusuke Shirota, Keiichi Osaka, and Yoshinari Abe
Subjects: Soil database, 010405 organic chemistry, 010401 analytical chemistry, Environmental science, Synchrotron radiation, X ray analysis, 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, Remote sensing
Published: 2017

46. Investigation of the Chemical Characteristics of Individual Radioactive Microparticles Emitted from Reactor 1 by the Fukushima Daiichi Nuclear Power Plant Accident by Using Multiple Synchrotron Radiation X-ray Analyses

Author: Yasuko Terada, Yukihiko Satou, Yushin Iizawa, Yoshinari Abe, Keisuke Sueki, Takahiro Ono, Yasuhito Igarashi, Kouji Adachi, and Izumi Nakai
Subjects: 0301 basic medicine, Nuclear engineering, Radiochemistry, X-ray, Bremsstrahlung, Radioactive waste, Synchrotron radiation, 010501 environmental sciences, 01 natural sciences, Analytical Chemistry, law.invention, 03 medical and health sciences, 030104 developmental biology, Fukushima daiichi, law, Nuclear power plant, Environmental science, Energy source, Isotopes of caesium, 0105 earth and related environmental sciences
Published: 2017

47. Efficacy of Electroconvulsive Therapy for Treatment-Resistant Depression Caused by Hyperparathyroidism

Author: Chikara Nakayama, Yoshihiro Matsumoto, Nobutaka Ayani, Jin Narumoto, Masaya Oda, Yoshinari Abe, and Takahiro Tsujikawa
Subjects: Psychiatry and Mental health, medicine.medical_specialty, Hyperparathyroidism, Electroconvulsive therapy, business.industry, Internal medicine, medicine.medical_treatment, Neuroscience (miscellaneous), medicine, MEDLINE, medicine.disease, business, Treatment-resistant depression
Published: 2020

48. Synchrotron Radiation X-ray Analyses of Heavy Minerals and Heavy Elements in River Sediments of Kyushu for Constructing a Forensic Soil Database

Author: Izumi Nakai, Yoshinari Abe, Shunsuke Furuya, Junko Hirokawa, Keiichi Osaka, Masayoshi Itou, and Issei Maeda
Subjects: 010504 meteorology & atmospheric sciences, Soil database, X-ray, Mineralogy, Synchrotron radiation, 010502 geochemistry & geophysics, 01 natural sciences, Geology, 0105 earth and related environmental sciences, Analytical Chemistry
Published: 2016

49. Hyper-influence of the orbitofrontal cortex over the ventral striatum in obsessive-compulsive disorder

Author: Seiji Nishida, Yoshinari Abe, Kenji Fukui, Kei Yamada, Jin Narumoto, Takashi Nakamae, and Yuki Sakai
Subjects: Adult, Male, Rest, Functional magnetic resonance imaging, Clinical Neurology, Prefrontal Cortex, Striatum, behavioral disciplines and activities, Brain mapping, Interview, Psychological, Neural Pathways, mental disorders, Obsessive-compulsive disorder, Orbitofrontal cortex, medicine, Humans, Pharmacology (medical), Resting state, Effective connectivity, Prefrontal cortex, Biological Psychiatry, Psychiatric Status Rating Scales, Pharmacology, Brain Mapping, Psychotropic Drugs, medicine.diagnostic_test, Resting state fMRI, Ventral striatum, Magnetic resonance imaging, Magnetic Resonance Imaging, Psychiatry and Mental health, medicine.anatomical_structure, nervous system, Neurology, Multivariate Analysis, Ventral Striatum, Female, Neurology (clinical), Psychology, Neuroscience, psychological phenomena and processes
Abstract: Dysfunction of the fronto-striato-thalamic circuit routing through the orbitofrontal cortex (OFC) is thought to play the main role in the pathophysiology of obsessive-compulsive disorder (OCD). Repetitious stimulation of the OFC–ventral striatum (VS) projections in mice has been shown to increase the firing of the postsynaptic VS cells and the frequency of OCD-like symptoms. Moreover, increased functional connectivity (FC) between the OFC and the VS has been reported in patients with OCD. While FC is a synchronous, non-directed correlation, the directed influence between these brain regions remains unclear in patients with OCD. We obtained resting state functional magnetic resonance imaging scans from 37 non-medicated patients with OCD and 38 matched healthy volunteers, and calculated bivariative voxel-wise Granger Causality (GC) to and from three striatal regions of interest (ROI) using a blind deconvolution procedure. Additionally, we conducted multivariative GC analysis to determine if the effect revealed by the bivariative voxel-wise GCA is mediated by another seed ROI. We found a significant hyper-influence of the OFC over the VS of subjects with OCD (p
Published: 2015

50. Investigation and Improvement of Metallic Aluminum as Alloying Electrode in Non-Aqueous Li Cells

Author: Takashi Matsuyama, Yoshinari Abe, Iori Abe, Kazuo Hida, Tatsuo Horiba, Satoshi Yasuno, and Shinichi Komaba
Subjects: Aqueous solution, Materials science, Renewable Energy, Sustainability and the Environment, chemistry.chemical_element, Metallic aluminum, Condensed Matter Physics, Lithium battery, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry, Chemical engineering, Aluminium, Electrode, Materials Chemistry, Electrochemistry
Published: 2020

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Database

Publisher

96 results on '"Yoshinari Abe"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources