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7. Surviving Sepsis After Burn Campaign

Author

Greenhalgh, David G., primary, Hill, David M., additional, Burmeister, David M., additional, Gus, Eduardo I., additional, Cleland, Heather, additional, Padiglione, Alex, additional, Holden, Dane, additional, Huss, Fredrik, additional, Chew, Michelle S., additional, Kubasiak, John C., additional, Burrell, Aidan, additional, Manzanares, William, additional, Gómez, María Chacón, additional, Yoshimura, Yuya, additional, Sjöberg, Folke, additional, Xie, Wei-Guo, additional, Egipto, Paula, additional, Lavrentieva, Athina, additional, Jain, Arpana, additional, Miranda-Altamirano, Ariel, additional, Raby, Ed, additional, Aramendi, Ignacio, additional, Sen, Soman, additional, Chung, Kevin K., additional, Alvarez, Renata Jennifer Quintana, additional, Han, Chunmao, additional, Matsushima, Asako, additional, Elmasry, Moustafa, additional, Liu, Yan, additional, Donoso, Carlos Segovia, additional, Bolgiani, Alberto, additional, Johnson, Laura S., additional, Vana, Luiz Philipe Molina, additional, de Romero, Rosario Valdez Duval, additional, Allorto, Nikki, additional, Abesamis, Gerald, additional, Luna, Virginia Nuñez, additional, Gragnani, Alfredo, additional, González, Carolina Bonilla, additional, Basilico, Hugo, additional, Wood, Fiona, additional, Jeng, James, additional, Li, Andrew, additional, Singer, Mervyn, additional, Luo, Gaoxing, additional, Palmieri, Tina, additional, Kahn, Steven, additional, Joe, Victor, additional, and Cartotto, Robert, additional

Published
2023
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9. Surviving Sepsis After Burn Campaign

Author

Greenhalgh, David G., Hill, David M., Burmeister, David M., Gus, Eduardo I., Cleland, Heather, Padiglione, Alex, Holden, Dane, Huss, Fredrik, Chew, Michelle S., Kubasiak, John C., Burrell, Aidan, Manzanares, William, Gomez, Maria Chacon, Yoshimura, Yuya, Sjoberg, Folke, Xie, Wei-Guo, Egipto, Paula, Lavrentieva, Athina, Jain, Arpana, Miranda-Altamirano, Ariel, Raby, Ed, Aramendi, Ignacio, Sen, Soman, Chung, Kevin K., Alvarez, Renata Jennifer Quintana, Han, Chunmao, Matsushima, Asako, Elmasry, Moustafa, Liu, Yan, Donoso, Carlos Segovia, Bolgiani, Alberto, Johnson, Laura S., Vana, Luiz Philipe Molina, de Romero, Rosario Valdez Duval, Allorto, Nikki, Abesamis, Gerald, Luna, Virginia Nunez, Gragnani, Alfredo, Gonzalez, Carolina Bonilla, Basilico, Hugo, Wood, Fiona, Jeng, James, Li, Andrew, Singer, Mervyn, Luo, Gaoxing, Palmieri, Tina, Kahn, Steven, Joe, Victor, Cartotto, Robert, Greenhalgh, David G., Hill, David M., Burmeister, David M., Gus, Eduardo I., Cleland, Heather, Padiglione, Alex, Holden, Dane, Huss, Fredrik, Chew, Michelle S., Kubasiak, John C., Burrell, Aidan, Manzanares, William, Gomez, Maria Chacon, Yoshimura, Yuya, Sjoberg, Folke, Xie, Wei-Guo, Egipto, Paula, Lavrentieva, Athina, Jain, Arpana, Miranda-Altamirano, Ariel, Raby, Ed, Aramendi, Ignacio, Sen, Soman, Chung, Kevin K., Alvarez, Renata Jennifer Quintana, Han, Chunmao, Matsushima, Asako, Elmasry, Moustafa, Liu, Yan, Donoso, Carlos Segovia, Bolgiani, Alberto, Johnson, Laura S., Vana, Luiz Philipe Molina, de Romero, Rosario Valdez Duval, Allorto, Nikki, Abesamis, Gerald, Luna, Virginia Nunez, Gragnani, Alfredo, Gonzalez, Carolina Bonilla, Basilico, Hugo, Wood, Fiona, Jeng, James, Li, Andrew, Singer, Mervyn, Luo, Gaoxing, Palmieri, Tina, Kahn, Steven, Joe, Victor, and Cartotto, Robert

Abstract

Introduction: The Surviving Sepsis Campaign was developed to improve outcomes for all patients with sepsis. Despite sepsis being the primary cause of death after thermal injury, burns have always been excluded from the Surviving Sepsis efforts. To improve sepsis outcomes in burn patients, an international group of burn experts developed the Surviving Sepsis After Burn Campaign (SSABC) as a testable guideline to improve burn sepsis outcomes. Methods: The International Society for Burn Injuries (ISBI) reached out to regional or na-tional burn organizations to recommend members to participate in the program. Two members of the ISBI developed specific "patient/population, intervention, comparison and out-come" (PICO) questions that paralleled the 2021 Surviving Sepsis Campaign [1]. SSABC parti-cipants were asked to search the current literature and rate its quality for each topic. At the Congress of the ISBI, in Guadalajara, Mexico, August 28, 2022, a majority of the participants met to create "statements" based on the literature. The "summary statements" were then sent to all members for comment with the hope of developing an 80% consensus. After four reviews, a consensus statement for each topic was created or "no consensus" was reported. Results: The committee developed sixty statements within fourteen topics that provide guidance for the early treatment of sepsis in burn patients. These statements should be used to improve the care of sepsis in burn patients. The statements should not be considered as "static" comments but should rather be used as guidelines for future testing of the best treatments for in burn should be on a basis. Conclusion: Members of the burn community from the around the world have developed the Surviving Sepsis After Burn Campaign guidelines with the goal of improving the outcome of sepsis in burn patients. (c) 2023 Elsevier Ltd and ISBI. All rights reserved.

Published
2023
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13. Japanese Society for Burn Injuries (JSBI) Clinical Practice Guidelines for Management of Burn Care (3rd Edition)

Author

Sasaki, Junichi, primary, Matsushima, Asako, additional, Ikeda, Hiroto, additional, Inoue, Yoshiaki, additional, Katahira, Jiro, additional, Kishibe, Miyuki, additional, Kimura, Chu, additional, Sato, Yukio, additional, Takuma, Kiyotsugu, additional, Tanaka, Katsumi, additional, Hayashi, Minoru, additional, Matsumura, Hajime, additional, Yasuda, Hiroshi, additional, Yoshimura, Yuya, additional, Aoki, Hiromichi, additional, Ishizaki, Yoshihisa, additional, Isono, Nobuo, additional, Ueda, Takahiro, additional, Umezawa, Kazuya, additional, Osuka, Akinori, additional, Ogura, Takayuki, additional, Kaita, Yasuhiko, additional, Kawai, Katsuya, additional, Kawamoto, Kyoko, additional, Kimura, Masahiko, additional, Kubo, Takatsugu, additional, Kurihara, Tomohiro, additional, Kurokawa, Masato, additional, Kobayashi, Shuken, additional, Saitoh, Daizoh, additional, Shichinohe, Ryuji, additional, Shibusawa, Takayuki, additional, Suzuki, Yuya, additional, Soejima, Kazutaka, additional, Hashimoto, Ichiro, additional, Fujiwara, Osamu, additional, Matsuura, Hiroshi, additional, Miida, Kazumasa, additional, Miyazaki, Michiteru, additional, Murao, Naoki, additional, Morikawa, Wataru, additional, and Yamada, Sachiko, additional

Published
2022
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16. S-15176 and its methylated derivative suppress the CsA-insensitive mitochondrial permeability transition and subsequent cytochrome c release induced by silver ion, and show weak protonophoric activity

Author

Kawashima, Satoshi, Yamamoto, Takenori, Horiuchi, Yuka, Fujiwara, Kengo, Gouda, Shunichi, Yoshimura, Yuya, Yamamoto, Atsushi, Inotani, Yuki, Yamashita, Kikuji, Kitamura, Seiichiro, Terada, Hiroshi, Kanematsu, Makoto, Shishido, Kozo, and Shinohara, Yasuo

Published
2011
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18. Efficacy of Body Armor in Protection against Blast Injuries using a Swine Model in a Confined Space with a Blast Tube

Author

Sekine, Yasumasa, primary, Saitoh, Daizoh, additional, Yoshimura, Yuya, additional, Fujita, Masanori, additional, Araki, Yoshiyuki, additional, Kobayashi, Yasushi, additional, Kusumi, Hitomi, additional, Yamagishi, Satomi, additional, Suto, Yuki, additional, Tamaki, Hiroshi, additional, Ono, Yosuke, additional, Mizukaki, Toshiharu, additional, and Nemoto, Manabu, additional

Published
2020
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20. Fulminant pseudomembranous enterocolitis caused by Klebsiella oxytoca : an autopsy case report

Author

Nagamura, Tatsunori, primary, Tanaka, Yoshihiro, additional, Terayama, Takero, additional, Higashiyama, Daishi, additional, Seno, Soichiro, additional, Isoi, Naoaki, additional, Katsurada, Yuka, additional, Matsubara, Akiko, additional, Yoshimura, Yuya, additional, Sekine, Yasumasa, additional, Akitomi, Shinji, additional, Sato, Kimiya, additional, Tsuda, Hitoshi, additional, Saitoh, Daizoh, additional, and Ikeuchi, Hisashi, additional

Published
2018
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26. 3P187 Synergistic inhibitory effects of oligomycin and rotenone on the mitochondrial permeability transition(Cell biology,Poster,The 52th Annual Meeting of the Biophysical Society of Japan(BSJ2014))

Author

Harada Kazuki, Yamamoto Takenori, Inotani Yuki, Shinohara Yasuo, Yoshimura Yuya, and Kotake Kazumasa

Subjects
chemistry.chemical_compound, Oligomycin, chemistry, Mitochondrial permeability transition pore, Rotenone, Biology, Inhibitory postsynaptic potential, Cell biology
Published
2014
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29. Bongkrekic Acid Analogue, Lacking One of the Carboxylic Groups of its Parent Compound, Shows Moderate but pH-insensitive Inhibitory Effects on the Mitochondrial ADP/ ATP Carrier.

Author

Yamamoto, Atsushi, Hasui, Keisuke, Matsuo, Hiroshi, Okuda, Katsuhiro, Abe, Masato, Matsumoto, Kenji, Harada, Kazuki, Yoshimura, Yuya, Yamamoto, Takenori, Ohkura, Kazuto, Shindo, Mitsuru, and Shinohara, Yasuo

Subjects
ENZYME inhibitors, BURKHOLDERIA, DICARBOXYLIC acids, MITOCHONDRIA, PH effect, ADENOSINE diphosphate, ADENOSINE triphosphate
Abstract

Bongkrekic acid, isolated from Burkholderia cocovenenans, is known to specifically inhibit the mitochondrial ADP/ ATP carrier. However, the manner of its interaction with the carrier remains elusive. In this study, we tested the inhibitory effects of 17 bongkrekic acid analogues, derived from the intermediates obtained during its total synthesis, on the mitochondrial ATP/ ATP carrier. Rough screening of these chemicals, performed by measuring their inhibitory effects on the mitochondrial ATP synthesis, revealed that 4 of them, KH-1, KH-7, KH-16, and KH-17, had moderate inhibitory effects. Further characterization of the actions of these 4 analogues on mitochondrial function showed that KH-16 had moderate; KH-1 and KH-17, weak; and KH-7, negligible side effects of both permeabilization of the mitochondrial inner membrane and inhibition of the electron transport, indicating that only KH-7 had a specific inhibitory effect on the mitochondrial ADP/ ATP carrier. Although the parental bongkrekic acid showed a strong pH dependency of its action, the inhibitory effect of KH-7 was almost insensitive to the pH of the reaction medium, indicating the importance of the 3 carboxyl groups of bongkrekic acid for its pH-dependent action. A direct inhibitory effect of KH-7 on the mitochondrial ADP/ ATP carrier was also clearly demonstrated. [ABSTRACT FROM AUTHOR]

Published
2015
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30. VDAC1, Having a Shorter N-Terminus Than VDAC2 but Showing the Same Migration in an SDS−Polyacrylamide Gel, Is the Predominant Form Expressed in Mitochondria of Various Tissues

Author

Yamamoto, Takenori, primary, Yamada, Akiko, additional, Watanabe, Masahiro, additional, Yoshimura, Yuya, additional, Yamazaki, Naoshi, additional, Yoshimura, Yoshiyuki, additional, Yamauchi, Takashi, additional, Kataoka, Masatoshi, additional, Nagata, Toshihiko, additional, Terada, Hiroshi, additional, and Shinohara, Yasuo, additional

Published
2006
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32. VDAC1, Having a Shorter N-Terminus Than VDAC2 but Showing the Same Migration in an SDS-Polyacrylamide Gel, Is the Predominant Form Expressed in Mitochondria of Various Tissues

Author

Yamamoto, Takenori, Yamada, Akiko, Watanabe, Masahiro, Yoshimura, Yuya, Yamazaki, Naoshi, Yoshimura, Yoshiyuki, Yamauchi, Takashi, Kataoka, Masatoshi, Nagata, Toshihiko, Terada, Hiroshi, and Shinohara, Yasuo

Abstract

The voltage-dependent anion channel (VDAC) is a pore-forming protein expressed in the outer membrane of eukaryotic mitochondria. Three isoforms of it, i.e., VDAC1, VDAC2, and VDAC3, are known to be expressed in mammals; however, the question as to which is the main isoform in mitochondria is still unanswered. To address this question, we first prepared standard VDACs by using a bacterial expression system and raised various antibodies against them by using synthetic peptides as immunogens. Of the three bacterially expressed VDAC isoforms, VDAC3 showed faster migration in SDS-polyacrylamide gels than VDAC1 and VDAC2, although VDAC2 is longer than VDAC1 and VDAC3, due to a 12-amino acid extension of its N-terminal region. Even with careful structural characterization of the expressed VDACs by LC-MS/MS analysis, serious structural modifications of VDACs causing changes in their migration in SDS-polyacrylamide gels were not detected. Next, immunoreactivities of the raised antibodies toward these bacterially expressed VDAC isoforms were evaluated. Trials to prepare specific antibodies against the three individual VDAC isoforms were not successful except in the case of VDAC1. However, using a synthetic peptide corresponding to the highly conserved region among the three VDACs, we were successful in preparing an antibody showing essentially equal imunoreactivities toward all three VDACs. When mitochondrial outer membrane proteins of various rat tissues were subjected to 2-dimensional electrophoresis followed by immunoblotting with this antibody, six immnoreactive protein spots were detected. These spots were characterized by LC-MS/MS analysis, and the signal intensities among the spots were compared. As a result, the signal intensity of the spot representing VDAC1 was the highest, and thus, VDAC1 was concluded to be the most abundantly expressed of the three VDAC isoforms in mammalian mitochondria.

Published
2006
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33. Real-time monitoring of mitochondrial adenosine 5′-triphosphate synthesis and hydrolysis by surface infrared spectroscopy.

Author

Yamaguchi, Ryo-taro, Hirano-Iwata, Ayumi, Aonuma, Yuki, Yoshimura, Yuya, Shinohara, Yasuo, Kimura, Yasuo, and Niwano, Michio

Subjects
ADENOSINE triphosphate, CHEMICAL synthesis, HYDROLYSIS, INFRARED spectroscopy, OPTICAL reflection, NUCLEOTIDES, TOXICITY testing
Abstract

We have developed a method for in situ real-time monitoring of adenosine 5′-triphosphate (ATP) synthesis in mitochondria using infrared absorption spectroscopy with the multiple internal reflection geometry. Spectral changes corresponding to ATP synthesis and hydrolysis were monitored under oxygenation and constant stirring condition. It was demonstrated that the reversible process of ATP synthesis in mitochondria can be monitored by analyzing stretching modes of α- and β-PO2- in adenine nucleotides. Our method has potential to evaluate mitochondrial toxicity in terms of mitochondrial activities of ATP synthesis and hydrolysis. [ABSTRACT FROM AUTHOR]

Published
2011
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34. Ca2+-induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions

Author

Yamada, Akiko, Yamamoto, Takenori, Yoshimura, Yuya, Gouda, Shunichi, Kawashima, Satoshi, Yamazaki, Naoshi, Yamashita, Kikuji, Kataoka, Masatoshi, Nagata, Toshihiko, Terada, Hiroshi, Pfeiffer, Douglas R., and Shinohara, Yasuo

Subjects
*PERMEABILITY, *CALCIUM ions, *MITOCHONDRIA, *YEAST, *PHOSPHATES, *APOPTOSIS, *CYTOCHROME c
Abstract

Yeast mitochondria have generally been believed not to undergo the permeability transition (PT) by the accumulation of Ca2+ within the mitochondrial matrix, unlike mammalian mitochondria. However, the reason why the yeast PT is not induced by Ca2+ has remained obscure. In this study, we examined in detail the effects of Ca2+ on yeast mitochondria under various conditions. As a result, we discovered that the PT could be induced even in yeast mitochondria by externally added Ca2+ under optimized experimental conditions. The 2 essential parameters for proper observation of the PT-inducing effects of Ca2+ were the concentrations of the respiratory substrate and that of inorganic phosphate (Pi) in the incubation medium. The yeast mitochondrial PT induced by Ca2+ was found to be insensitive to cyclosporin A and suppressed in the presence of a high concentration of Pi. Furthermore, when the PT was induced in yeast mitochondria by Ca2+, the release of cytochrome c from mitochondria was also observed. [Copyright &y& Elsevier]

Published
2009
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