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31 results on '"Yoshimura, Masaya"'

2. Efficacy and safety of vonoprazan-based regimen for Helicobacter pylori eradication therapy in Japanese adolescents: a prospective multicenter study

Author

Kakiuchi, Toshihiko, Matsuo, Muneaki, Endo, Hiroyoshi, Sakata, Yasuhisa, Esaki, Motohiro, Noda, Takahiro, Imamura, Ichiro, Hashiguchi, Kazutoshi, Ogata, Shinichi, Fujioka, Yasuhiko, Hanada, Keiichiro, Fukuda, Kayoko, Yoshimura, Masaya, Kajiwara, Tetsuro, Yamamoto, Kentaroh, Yamaguchi, Daisuke, Kawakubo, Hiroharu, Matsunaga, Takuya, Sumino, Michihiro, Matsunaga, Keiji, Muro, Eriko, Watanabe, Akira, and Fujimoto, Kazuma

Published
2023
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4. Method for quantifying the Pasteurella multocida antigen adsorbed on aluminum hydroxide adjuvant in swine atrophic rhinitis vaccine.

Author

Yoshimura, Masaya, Honda, Youko, Yonemitsu, Emi, Kuraoka, Kasumi, and Suenaga, Kiyotaka

Subjects
*PASTEURELLA multocida, *ALUMINUM hydroxide, *RHINITIS, *ANTIGENS, *SWINE, *SWINE farms
Abstract

Swine atrophic rhinitis is a disease caused by Pasteurella multocida and Bordetella bronchiseptica that affects pigs. Inactivated vaccines containing the toxins produced by Pasteurella multocida and Bordetella bronchiseptica have been widely used for the prevention of swine atrophic rhinitis. The efficacy of a vaccine is correlated with the amount of antigen present; however, the protective toxin of P. multocida bound to aluminum hydroxide, which is used as an adjuvant, can hinder the monitoring of the antigen concentration in the vaccine. This study assessed the applicability of a dot immunoassay as an antigen quantification method using monoclonal antibodies. This quantification method was able to detect the antigen with high specificity and sensitivity even when the antigen was bound to the adjuvant, and its application to vaccine products revealed a correlation between the amount of antigen present in the vaccine and the neutralizing antibody titers induced in pigs. The antigen quantification method presented in this study is a simple and sensitive assay capable of quantifying the amount of antigen present in a vaccine that can be used as an alternative quality control measure. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Efficacy and safety of vonoprazan-based regimen for Helicobacter pylori eradication therapy in Japanese adolescents: a prospective multicenter study

Author

Kakiuchi, Toshihiko, primary, Matsuo, Muneaki, additional, Endo, Hiroyoshi, additional, Sakata, Yasuhisa, additional, Esaki, Motohiro, additional, Noda, Takahiro, additional, Imamura, Ichiro, additional, Hashiguchi, Kazutoshi, additional, Ogata, Shinichi, additional, Fujioka, Yasuhiko, additional, Hanada, Keiichiro, additional, Fukuda, Kayoko, additional, Yoshimura, Masaya, additional, Kajiwara, Tetsuro, additional, Yamamoto, Kentaroh, additional, Yamaguchi, Daisuke, additional, Kawakubo, Hiroharu, additional, Matsunaga, Takuya, additional, Sumino, Michihiro, additional, Matsunaga, Keiji, additional, Muro, Eriko, additional, Watanabe, Akira, additional, and Fujimoto, Kazuma, additional

Published
2022
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9. Gastrointestinal adverse reactions reduce the success rate of Helicobacter pylori eradication therapy: A multicenter prospective cohort study

Author

Kakiuchi, Toshihiko, primary, Matsuo, Muneaki, additional, Endo, Hiroyoshi, additional, Sakata, Yasuhisa, additional, Esaki, Motohiro, additional, Noda, Takahiro, additional, Imamura, Ichiro, additional, Hashiguchi, Kazutoshi, additional, Ogata, Shinichi, additional, Fujioka, Yasuhiko, additional, Hanada, Keiichiro, additional, Fukuda, Kayoko, additional, Yoshimura, Masaya, additional, Kajiwara, Tetsuro, additional, Yamamoto, Kentaroh, additional, Yamaguchi, Daisuke, additional, Kawakubo, Hiroharu, additional, Akashi, Taro, additional, Sumino, Michihiro, additional, Matsunaga, Keiji, additional, Muro, Eriko, additional, Kuwahara, Atsuo, additional, Taniguchi, Kazuto, additional, Fukuyama, Koji, additional, Watanabe, Akira, additional, Takamori, Ayako, additional, Okuda, Masumi, additional, Yamanouchi, Kohei, additional, and Fujimoto, Kazuma, additional

Published
2020
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13. Gastrointestinal adverse reactions reduce the success rate of Helicobacter pylori eradication therapy: A multicenter prospective cohort study.

Author

Kakiuchi, Toshihiko, Matsuo, Muneaki, Endo, Hiroyoshi, Sakata, Yasuhisa, Esaki, Motohiro, Noda, Takahiro, Imamura, Ichiro, Hashiguchi, Kazutoshi, Ogata, Shinichi, Fujioka, Yasuhiko, Hanada, Keiichiro, Fukuda, Kayoko, Yoshimura, Masaya, Kajiwara, Tetsuro, Yamamoto, Kentaroh, Yamaguchi, Daisuke, Kawakubo, Hiroharu, Akashi, Taro, Sumino, Michihiro, and Matsunaga, Keiji

Subjects
JUNIOR high school students, HELICOBACTER pylori, HELICOBACTER pylori infections, COHORT analysis, LONGITUDINAL method
Abstract

Background: The screening and treatment of Helicobacter pylori infection for all junior high students in Saga Prefecture, Japan, were started in 2016. The present study aims to evaluate the influence of adverse reactions on the success of the eradication therapy. Methods: From 2017 to 2019, 25,006 third‐grade junior high school students were tested for urinary anti‐H. pylori antibodies. Positive cases were confirmed by H. pylori stool antigen tests. Of the 531 students who were found to be H. pylori‐positive, 390 (358 in first‐line and 32 in second‐line therapy) underwent eradication therapy, and 274 (242 in first‐line and 32 in second‐line) students actually completed a self‐reported form to rate stool consistency (based on the Bristol Stool Scale), the maximum number of bowel movements, and abdominal symptoms during the 7 days of treatment. Results: Among the 274 students, the total of primary and secondary eradication success rates was 87% (95% confidential interval: 82.9–90.1) in intention‐to‐treat analysis. On days 4, 5, and 6, stool consistency was looser in the primary eradication failure group than in the success group (p <.05). Looser stool consistencies were observed in male students with abdominal pain compared to those who did not experience pain (p <.05). Abdominal pain and diarrhea were detected in 28.5% and 42.7% of the subjects, respectively. The overall incidence of other adverse events was low (n = 8/274, 2.9%), and only two students discontinued treatment because of adverse events. Conclusions: Softening of the stool was related to the eradication failure in the junior high school students, especially in males with abdominal pain. Adverse effects did not induce discontinuation of the eradication treatment. [ABSTRACT FROM AUTHOR]

Published
2021
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15. Detection of Epstein-Barr Virus and Helicobacter pylori in Primary Malignant Gastric Lymphomas

Author

Shikuwa, Saburo, Matsunaga, Keiichiro, Isomoto, Hajime, Osabe, Masayuki, Takehara, Yusuke, Ofukuji, Megumi, Yoshimura, Masaya, Ito, Akira, Simokawa, Isao, Ito, Masahiro, Murase, Kunihiko, Takeshima, Fuminao, Omagari, Katsuhisa, Mizuta, Yohei, and Kohno, Shigeru

Subjects
immune system diseases, primary gastric malignant lymphoma (PGML), hemic and lymphatic diseases, in situ hybridization (ISH), Epstein-Barr virus (EBV) Helicobacter pylori (H.pylori)
Abstract

We studied five patients diagnosed with primary gastric lymphoma between 1985 and 1995 in Omura Munisipa Hospital to investigate the relationship between Helicobacter pylori, Epstein-Barr virus and primary malignant gastric lymphoma. H. pylori was detected by hematoxylin-eosin stain, Giemsa stain, immunohistochemistry while EBV was detected by in situ hybridization in the lymphoma and background mucosa. H. pylori but not EBV, was detected in all cases. Furthermore, malignant lymphomas were mainly located in the area of the fundic gland where H. pylori was frequently identified and caused inflammation. In contrast, malignant lymphomas were not detected in areas with intestinal metaplasia. Our results suggest that malignant lymphoma may develop in a region where the immune system has been activated by H. pylori. In contrast, EBV is unlikely to play an important role in the development of gastric lymphoma, compared to H. pylori., Acta medica Nagasakiensia. 1998, 43(3-4), p.72-78

Published
1998

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