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Background Individuals with early-onset Alzheimer disease (EOAD) differ from those with late-onset Alzheimer disease (LOAD) not only in genetics and age at onset but also in their clinical symptoms. Objective To differentiate the neuropathological and neurocognitive features of EOAD and LOAD by comparing the pattern of regional gray matter volume (GMV) reduction and its symptomatic correlates. Method Three-dimensional T1-weighted MRIs and Mini-Mental State Examination (MMSE) scores were obtained from 12 individuals with EOAD, 65 with LOAD, and 49 healthy controls (HC). Regional GMV reduction between the three groups was assessed using voxel-based morphometry. Multiple regression analyses were conducted with MMSE total score as an independent variable. Results Compared to the HC, both AD groups showed a significant GMV reduction in the bilateral hippocampus and the left temporoparietal junction; in addition, the LOAD group showed one in the bilateral anterior temporal lobes. Multiple regression analyses revealed a positive correlation between MMSE total score and GMV in the left anterior temporal lobe in both AD groups; that is, lower scores were associated with reduced GMV. Interestingly, a positive correlation in hippocampal GMV was revealed only in the LOAD group. Conclusion MMSE total score is associated with the anterior temporal lobe volume in individuals with AD. Hippocampal volume and its relationship with MMSE total score are associated with LOAD pathophysiology but not EOAD pathophysiology. The hippocampal volume reduction and low MMSE scores are hallmarks of LOAD but are less specific to EOAD, which may cause a delay in diagnosis.

Up-link Laser Differential Absorption Sensing: ULDAS, shown in Fig.1, is a new method to measure green house gas concentration with earth observation satellites. Although the measurement area is restricted in only small visible area of an optical ground station, ULDAS has outstanding features as followed: - Faster: Easy to development, small size and small resource requirements to satellite system - Better: High accuracy (CO 2 observation error of weighted column is - Cheaper: Simple system, small number of parts and no special parts The flight segment of the ULDAS is able to be loaded on a marginal resource of green house effect observation satellites, such as Japanese GOSAT-series. In this paper, the feasibility study of the mission concept and field experiments are reported.

To meet increasing demands of high-speed data transmission, JAXA has started to develop a new optical data relay system. This system provides 1.8Gbit/s data relay service through optical inter-satellite link and Ka-band feeder link using JDRS, a data relay satellite. The first user satellite is the Advanced Optical Satellite, a Japanese optical observation satellite in low earth orbit. As a total data relay system, the data relay satellite, Ka-band ground stations and two optical terminals for JDRS and the Advanced Optical Satellite are developed together. Target launch year of JDRS is 2019 in Japanese fiscal year. This paper describes the development plan and technologies of the optical data relay system.

After 13 years successful operation of Japanese first data relay satellite “KODAMA,” JAXA has initiated a new data relay satellite programme which adapts optical communication in the inter-orbit link. The programme includes development of a data relay satellite and optical terminals both for GEO (i.e. the data relay satellite) and LEO, Ka feeder link system to communicate between the data relay satellite and ground stations and has data-relay service capability up to 1.8 Gbps. Targets launch year is 2019 in Japanese fiscal year. In the paper, the authors outline the plan of the programme and its technology.

Tandem-L is a proposal for an innovative interferometric radar mission to monitor the Earth system and its intricate dynamics. Important mission objectives are global inventories of forest height and above-ground biomass, largescale measurements of Earth surface deformations due to plate tectonics, erosion and anthropogenic activities, observations of glacier movements and 3-D structure changes in land and sea ice, and the monitoring of ocean surface currents. The mission concept is based on co-flying two fully-polarimetric L-band SAR satellites in a close formation. Tandem-L employs new techniques and advanced technologies to achieve its ambitious mission goals. The feasibility of a joint DLR/JAXA mission is currently being investigated in the scope of a pre-phase A study.

High-accuracy three-dimensional (3D) information of global area is useful in various fields, such as global observations of canopy height, elevation and ice sheet. Especially, there are pressing needs to advance understanding of how changes in the 3D structure of terrestrial vegetation are affecting the global carbon dynamics and their implications for climate change. Thus new space based observations are needed to measure global maps of the 3D structure of vegetation. Japan Aerospace Exploration Agency has started a conceptual study of the spaceborne vegetation LiDAR called MOLI (Multi- Footprint Observation LiDAR and Imager) which will enable us to obtain high-accuracy 3D information of vegetation areas from the globe. To investigate waveforms and analysis procedure, the waveform-simulator for MOLI was developed. Comparing with previous studies about the canopy height estimation from GLAS waveforms, waveform analysis procedure in which waveforms were fitted with a sum of Gaussian functions was studied. The maximum canopy height error was divided into two components; the basic error (EB) which was not depending on terrain index (TI), which was the vertical difference between the highest and lowest elevation within a footprint, and the error depending on TI (ETI). The total error (ETotal) could be RMS of the two. We propose ETotal in which EB is 1 m and ETI is 1/3*TI as a target observation accuracy of MOLI. According to this error estimation, the observation accuracy of MOLI is 1m at a plane area (TI ≈ 0) and 3 m at slope area up to about 20 degree.

Laser remote sensing technologies are valuable for a variety of scientific requirements. These measurement techniques are involved in several earth science areas, including atmospheric chemistry, aerosols and clouds, wind speed and directions, prediction of pollution, oceanic mixed layer depth, vegetation canopy height (biomass), ice sheet, surface topography, and others. Much of these measurements have been performed from the ground to aircraft over the past decades. To improve knowledge of these science areas with transport models (e.g. AGCM), further advances of vertical profile are required. JAXA collaborated with NICT and RIKEN started a new cross-sectional 3-year program to improve a technology readiness of the critical 1-micron wavelengths from 2011. The efficient frequency conversions such as second and third harmonic generation and optical parametric oscillation/generation are applied. A variety of elements are common issues to lidar instruments, which includes heat rejection using high thermal conductivity materials, laser diode life time and reliability, wavelength control, and suppression of contamination control. And the program has invested in several critical areas including advanced laser transmitter technologies to enable science measurements and improvement of knowledge for space-based laser diode arrays, Pockels cells, advanced nonlinear wavelength conversion technology for space-based LIDIRs. Final goal is aim to realize 15 watt class Q-switched pulse laser over 3-year lifetime.

A conceptual study was undertaken on earth observation missions for a satellite within the Sun-Synchronous and Medium Earth Orbit (SS-MEO). Our mission study of a MEO Satellite was performed as pioneering research into a newly utilized earth orbit that exists between the Low Earth Orbit (LEO) and the Geostationary Earth Orbit (GEO). One of the advantages of the MEO is that it delivers a wider field of view (FOV), which permits more frequent observations that are more easily obtained, in comparison with the LEO. Another advantage is that the performance demands for sensors are moderate, relative to those for the GEO. This conceptual study of earth observation missions is considered for the baseline (4184 km) orbits, focusing on optical sensors. We summarize the needs of each assumed user (products, observational frequency, and spatial resolution) related to four missions (agricultural, forest, ocean, and air pollution observations). Agricultural observation is expected to need a spatial resolution of 10 m and an observational frequency of a few times a week. As a result, required optical sensor is that with an aperture diameter of 30 cm, an f-number of 11, and a signal-to-noise ratio (S/N) of 20. It is thought that the optical sensor for the agricultural observation would be larger in comparison with the previous optical sensors used within the LEO, because the S/N and FOV are smaller. However, it was found there is a challenge to be met in terms of a compatibility with the f-number and FOV. This paper shows the results of this conceptual study and the issues raised relating to mission sensors for earth observation missions in the MEO., 資料番号: PA1410077000

The Medium Earth Orbit (MEO) offers a greater width of satellite view than the Low Earth Orbit, and a greater roximity to the Earth’s surface than the Geostationary Earth Orbit. Global positioning systems and ionospheric sounding satellites have already operated in this orbit, and the MEO will appeal to satellite missions undertaking Earth observations,communications, positioning, and scientific explorations. The Sun-Synchronous Medium Earth Orbits (SS-MEOs) used in this study enable clear and daily observations of the Earth’s surface. However, problems such as severe radiation from the Van Allen radiation belt, and the inefficiency to launch a satellite in a southwest direction, need to be resolved. This paper presents the results of early studies on SS-MEO utilization: orbital characteristics and environments, candidates for Earthobservation missions, and the feasibility of the development and launch of a satellite for operation within this orbit., 資料番号: PA1410079000