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564 results on '"Yoshikawa, Yuki"'

1. Predicting time to castration resistance with androgen-receptor signaling inhibitors in hormone-sensitive prostate cancer: data from ULTRA-Japan Consortium

Author

Uchimoto, Taizo, Iwatsuki, Kengo, Komura, Kazumasa, Fukuokaya, Wataru, Adachi, Takahiro, Hirasawa, Yosuke, Hashimoto, Takeshi, Yoshizawa, Atsuhiko, Saruta, Masanobu, Fujimoto, Saizo, Minami, Takafumi, Yamamoto, Yutaka, Yamazaki, Shogo, Takai, Tomoaki, Sakamoto, Moritoshi, Nakajima, Yuki, Nishimura, Kazuki, Maenosono, Ryoichi, Tsujino, Takuya, Nakamura, Ko, Fukushima, Tatsuo, Nishio, Kyosuke, Yoshikawa, Yuki, Yamamoto, Shutaro, Iwatani, Kosuke, Urabe, Fumihiko, Mori, Keiichiro, Yanagisawa, Takafumi, Tsuduki, Shunsuke, Takahara, Kiyoshi, Inamoto, Teruo, Fujita, Kazutoshi, Kimura, Takahiro, Ohno, Yoshio, Shiroki, Ryoichi, and Azuma, Haruhito

Published
2025
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2. Characterization of PSA dynamics and oncological outcomes in patients with metastatic hormone-sensitive prostate cancer treated with androgen receptor signaling inhibitors

Author

Yamada, Yasutaka, Sato, Kodai, Sakamoto, Shinichi, Tsujino, Takuya, Saito, Sinpei, Nishimura, Kazuki, Fukushima, Tatsuo, Nakamura, Ko, Yoshikawa, Yuki, Matsunaga, Tomohisa, Maenosono, Ryoichi, Kanesaka, Manato, Arai, Takayuki, Sazuka, Tomokazu, Imamura, Yusuke, Komura, Kazumasa, Mikami, Kazuo, Nakamura, Kazuyoshi, Fukasawa, Satoshi, Chiba, Kazuto, Naya, Yukio, Nagata, Maki, Komaru, Atsushi, Nakatsu, Hiroomi, Azuma, Haruhito, and Ichikawa, Tomohiko

Published
2024
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5. Nephron-sparing ureteroscopic surgery vs. radical nephroureterectomy: comparable survival-outcomes in upper tract urothelial carcinoma

Author

Tsujino, Takuya, Komura, Kazumasa, Inamoto, Teruo, Maenosono, Ryoichi, Hashimoto, Takeshi, Adachi, Takahiro, Hirasawa, Yosuke, Tokushige, Satoshi, Ohno, Takaya, Yamazaki, Shogo, Fukushima, Tatsuo, Nakamura, Ko, Yano, Yusuke, Nishimura, Kazuki, Kinoshita, Shoko, Nakamori, Keita, Tsutsumi, Takeshi, Matsunaga, Tomohisa, Yoshikawa, Yuki, Uchimoto, Taizo, Takai, Tomoaki, Minami, Koichiro, Uehara, Hirofumi, Hirano, Hajime, Nomi, Hayahito, Takahara, Kiyoshi, Ohno, Yoshio, and Azuma, Haruhito

Published
2023
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6. Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans

Author

Murase, Shuhei, Sakitani, Naoyoshi, Maekawa, Takahiro, Yoshino, Daisuke, Takano, Kouji, Konno, Ayumu, Hirai, Hirokazu, Saito, Taku, Tanaka, Sakae, Shinohara, Keisuke, Kishi, Takuya, Yoshikawa, Yuki, Sakai, Takamasa, Ayaori, Makoto, Inanami, Hirohiko, Tomiyasu, Koji, Takashima, Atsushi, Ogata, Toru, Tsuchimochi, Hirotsugu, Sato, Shinya, Saito, Shigeyoshi, Yoshino, Kohzoh, Matsuura, Yuiko, Funamoto, Kenichi, Ochi, Hiroki, Shinohara, Masahiro, Nagao, Motoshi, and Sawada, Yasuhiro

Published
2023
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8. Temperature Dependence of Polymer Network Diffusion

Author

Fujiyabu, Takeshi, Sakai, Takamasa, Kudo, Ryota, Yoshikawa, Yuki, Katashima, Takuya, Chung, Ung-il, and Sakumichi, Naoyuki

Subjects
Condensed Matter - Soft Condensed Matter, Condensed Matter - Materials Science, Condensed Matter - Statistical Mechanics, Physics - Chemical Physics
Abstract

The swelling dynamics of polymer gels are characterized by the (collective) diffusion coefficient $D$ of the polymer network. Here, we measure the temperature dependence of $D$ of polymer gels with controlled homogeneous network structures using dynamic light scattering. An evaluation of the diffusion coefficient at the gelation point $D_{\mathrm{gel}}$ and the increase therein as the gelation proceeds $\Delta D\equiv D-D_{\mathrm{gel}}$ indicates that $\Delta D$ is a linear function of the absolute temperature with a significantly large negative constant term. This feature is formally identical to the recently discovered "negative energy elasticity" [Y. Yoshikawa et al., Phys. Rev. X 11, 011045 (2021) (arXiv:1912.13191)], demonstrating a nontrivial similarity between the statics and dynamics of polymer networks., Comment: 6+4 pages, 3+6 figures; published version

Published
2021
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9. Linear elasticity of polymer gels in terms of negative energy elasticity

Author

Sakumichi, Naoyuki, Yoshikawa, Yuki, and Sakai, Takamasa

Subjects
Condensed Matter - Soft Condensed Matter, Condensed Matter - Materials Science, Condensed Matter - Statistical Mechanics, Physics - Chemical Physics
Abstract

We recently found that the energy contribution to the linear elasticity of polymer gels in the as-prepared state can be a significant negative value; the shear modulus is not proportional to the absolute temperature [Y. Yoshikawa et al., Phys. Rev. X 11, 011045 (2021) (arXiv:1912.13191)]. Our finding challenges the conventional notion that the polymer-gel elasticity is mainly determined by the entropy contribution. Existing molecular models of classical rubber elasticity theories, including the affine, phantom, and junction affine network models, cannot be used to estimate the structural parameters of polymer gels. In this focus review, we summarize the experimental studies on the linear elasticity of polymer gels in the as-prepared state using tetra-arm poly(ethylene glycol) (PEG) hydrogels with a homogenous polymer network. We also provide a unified formula for the linear elasticity of polymer gels with various network topologies and densities. Using the unified formula, we reconcile the past experimental results that seemed to be inconsistent with each other. Finally, we mention that there are still fundamental unresolved problems involving the linear elasticity of polymer gels., Comment: 10 pages, 6 figures; published version; This is an invited Focus Review based on arXiv:1912.13191 [Phys. Rev. X 11, 011045 (2021)], where Focus Review is a smaller review focusing on a clearly defined topic of author's own research

Published
2021
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10. The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer

Author

Komura, Kazumasa, Hirosuna, Kensuke, Tokushige, Satoshi, Tsujino, Takuya, Nishimura, Kazuki, Ishida, Mitsuaki, Hayashi, Takuo, Ura, Ayako, Ohno, Takaya, Yamazaki, Shogo, Nakamori, Keita, Kinoshita, Shoko, Maenosono, Ryoichi, Ajiro, Masahiko, Yoshikawa, Yuki, Takai, Tomoaki, Tsutsumi, Takeshi, Taniguchi, Kohei, Tanaka, Tomohito, Takahara, Kiyoshi, Konuma, Tsuyoshi, Inamoto, Teruo, Hirose, Yoshinobu, Ono, Fumihito, Shiraishi, Yuichi, Yoshimi, Akihide, and Azuma, Haruhito

Published
2023
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11. Clinical significance of primary tumor progression in metastatic hormone-sensitive prostate cancer

Author

Yamada, Yasutaka, Sakamoto, Shinichi, Tsujino, Takuya, Saito, Sinpei, Sato, Kodai, Nishimura, Kazuki, Fukushima, Tatsuo, Nakamura, Ko, Yoshikawa, Yuki, Matsunaga, Tomohisa, Maenosono, Ryoichi, Kanesaka, Manato, Arai, Takayuki, Sazuka, Tomokazu, Imamura, Yusuke, Komura, Kazumasa, Mikami, Kazuo, Nakamura, Kazuyoshi, Fukasawa, Satoshi, Chiba, Kazuto, Naya, Yukio, Nagata, Maki, Komaru, Atsushi, Nakatsu, Hiroomi, Azuma, Haruhito, and Ichikawa, Tomohiko

Published
2024
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13. Negative energy elasticity in a rubberlike gel

Author

Yoshikawa, Yuki, Sakumichi, Naoyuki, Chung, Ung-il, and Sakai, Takamasa

Subjects
Condensed Matter - Soft Condensed Matter, Condensed Matter - Materials Science, Condensed Matter - Statistical Mechanics, Physics - Chemical Physics
Abstract

Rubber elasticity is the archetype of the entropic force emerging from the second law of thermodynamics; numerous experimental and theoretical studies on natural and synthetic rubbers have shown that the elasticity originates mostly from entropy change with deformation. Similarly, in polymer gels containing a large amount of solvent, it has also been postulated that the shear modulus (the modulus of rigidity) $G$, which is a kind of modulus of elasticity, is approximately equivalent to the entropy contribution $G_S$, but this has yet to be verified experimentally. In this study, we measure the temperature dependence of the shear modulus $G$ in a rubberlike (hyperelastic) polymer gel whose polymer volume fraction is at most 0.1. As a result, we find that the energy contribution $G_E=G-G_S$ can be a significant negative value, reaching up to double the shear modulus $G$ (i.e., $\left|G_E\right| \simeq 2G$), although the shear modulus of stable materials is generally bound to be positive. We further argue that the energy contribution $G_E$ is governed by a vanishing temperature that is a universal function of the normalized polymer concentration, and $G_E$ vanishes when the solvent is removed. Our findings highlight the essential difference between rubber elasticity and gel elasticity (which were previously thought to be the same) and push the established field of gel elasticity into a new direction., Comment: 12 pages, 8 figures; published version

Published
2019
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14. Author Correction: Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans

Author

Murase, Shuhei, Sakitani, Naoyoshi, Maekawa, Takahiro, Yoshino, Daisuke, Takano, Kouji, Konno, Ayumu, Hirai, Hirokazu, Saito, Taku, Tanaka, Sakae, Shinohara, Keisuke, Kishi, Takuya, Yoshikawa, Yuki, Sakai, Takamasa, Ayaori, Makoto, Inanami, Hirohiko, Tomiyasu, Koji, Takashima, Atsushi, Ogata, Toru, Tsuchimochi, Hirotsugu, Sato, Shinya, Saito, Shigeyoshi, Yoshino, Kohzoh, Matsuura, Yuiko, Funamoto, Kenichi, Ochi, Hiroki, Shinohara, Masahiro, Nagao, Motoshi, and Sawada, Yasuhiro

Published
2023
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17. Efficacy and safety of chemoradiation therapy using one-shot cisplatin via hepatic arterial infusion for advanced hepatocellular carcinoma with major macrovascular invasion: a single-arm retrospective cohort study

Author

Naruto, Kensuke, Kawaoka, Tomokazu, Kodama, Kenichiro, Ogawa, Yutaro, Amioka, Kei, Yoshikawa, Yuki, Kikukawa, Chihiro, Suehiro, Yousuke, Yamaoka, Kenji, Ando, Yuwa, Kosaka, Yumi, Uchikawa, Shinsuke, Nakahara, Takashi, Murakami, Eisuke, Ono, Atsushi, Uchida, Takuro, Yamauchi, Masami, Okamoto, Wataru, Takahashi, Shoichi, Imamura, Michio, Chosa, Keigo, Awai, Kazuo, Kubo, Katsumaro, Nagata, Yasushi, Chayama, Kazuaki, and Aikata, Hiroshi

Published
2022
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18. Prevalence of immune-related adverse events and anti-tumor efficacy following immune checkpoint inhibitor therapy in Japanese patients with various solid tumors

Author

Yoshikawa, Yuki, Imamura, Michio, Yamauchi, Masami, Hayes, C. Nelson, Aikata, Hiroshi, Okamoto, Wataru, Miyata, Yoshihiro, Okada, Morihito, Hattori, Noboru, Sugiyama, Kazuhiko, Yoshioka, Yukio, Toratani, Shigeaki, Takechi, Masaaki, Ichinohe, Tatsuo, Ueda, Tsutomu, Takeno, Sachio, Kobayashi, Tsuyoshi, Ohdan, Hideki, Teishima, Jun, Hide, Michihiro, Nagata, Yasushi, Kudo, Yoshiki, Iida, Koji, and Chayama, Kazuaki

Published
2022
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25. Mechanical Regulation Underlies Effects of Exercise on Serotonin-Induced Signaling in the Prefrontal Cortex Neurons

Author

Ryu, Youngjae, Maekawa, Takahiro, Yoshino, Daisuke, Sakitani, Naoyoshi, Takashima, Atsushi, Inoue, Takenobu, Suzurikawa, Jun, Toyohara, Jun, Tago, Tetsuro, Makuuchi, Michiru, Fujita, Naoki, Sawada, Keisuke, Murase, Shuhei, Watanave, Masashi, Hirai, Hirokazu, Sakai, Takamasa, Yoshikawa, Yuki, Ogata, Toru, Shinohara, Masahiro, Nagao, Motoshi, and Sawada, Yasuhiro

Published
2020
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29. Adjuvant chemotherapy improves overall survival in patients with localized upper tract urothelial carcinoma harboring pathologic vascular invasion: a propensity score-matched analysis of multi-institutional cohort

Author

Matsunaga, Tomohisa, Komura, Kazumasa, Hashimoto, Takeshi, Muraoka, Ryu, Satake, Naoya, Tsutsumi, Takeshi, Tsujino, Takuya, Yoshikawa, Yuki, Takai, Tomoaki, Minami, Koichiro, Taniguchi, Kohei, Tanaka, Tomohito, Uehara, Hirofumi, Hirano, Hajime, Nomi, Hayahito, Ibuki, Naokazu, Takahara, Kiyoshi, Inamoto, Teruo, Ohno, Yoshio, and Azuma, Haruhito

Published
2020
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32. Distinct effect of body mass index by sex as a prognostic factor in localized renal cell carcinoma treated with nephrectomy ~ data from a multi-institutional study in Japan ~

Author

Tsutsumi, Takeshi, Komura, Kazumasa, Hashimoto, Takeshi, Muraoka, Ryu, Satake, Naoya, Matsunaga, Tomohisa, Tsujino, Takuya, Yoshikawa, Yuki, Takai, Tomoaki, Minami, Koichiro, Taniguchi, Kohei, Tanaka, Tomohito, Uehara, Hirofumi, Hirano, Hajime, Nomi, Hayahito, Ibuki, Naokazu, Takahara, Kiyoshi, Inamoto, Teruo, Ohno, Yoshio, and Azuma, Haruhito

Published
2021
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40. The CANLPH Score, an Integrative Model of Systemic Inflammation and Nutrition Status (SINS), Predicts Clinical Outcomes After Surgery in Renal Cell Carcinoma: Data From a Multicenter Cohort in Japan

Author

Komura, Kazumasa, Hashimoto, Takeshi, Tsujino, Takuya, Muraoka, Ryu, Tsutsumi, Takeshi, Satake, Naoya, Matsunaga, Tomohisa, Yoshikawa, Yuki, Takai, Tomoaki, Minami, Koichiro, Taniguchi, Kohei, Uehara, Hirofumi, Tanaka, Tomohito, Hirano, Hajime, Nomi, Hayahito, Ibuki, Naokazu, Takahara, Kiyoshi, Inamoto, Teruo, Ohno, Yoshio, and Azuma, Haruhito

Published
2019
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41. Tertiary lymphoid structure and neutrophil–lymphocyte ratio coordinately predict outcome of pembrolizumab

Author

Komura, Kazumasa, primary, Tokushige, Satoshi, additional, Ishida, Mitsuaki, additional, Hirosuna, Kensuke, additional, Yamazaki, Shogo, additional, Nishimura, Kazuki, additional, Ajiro, Masahiko, additional, Ohno, Takaya, additional, Nakamori, Keita, additional, Kinoshita, Shoko, additional, Tsujino, Takuya, additional, Maenosono, Ryoichi, additional, Yoshikawa, Yuki, additional, Takai, Tomoaki, additional, Tsutsumi, Takeshi, additional, Taniguchi, Kohei, additional, Tanaka, Tomohito, additional, Takahara, Kiyoshi, additional, Inamoto, Teruo, additional, Hirose, Yoshinobu, additional, Ono, Fumihito, additional, Shiraishi, Yuichi, additional, Yoshimi, Akihide, additional, and Azuma, Haruhito, additional

Published
2023
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44. Role of Aggressive Aneurysm Sac Embolization Before Endovascular Abdominal Aneurysm Repair in Preventing Type II Endoleak and Sac Expansion

Author

Yoshikawa, Yasushi, Kishimoto, Satoru, Takasugi, Shohei, Kishimoto, Yuichiro, Onohara, Takeshi, Kumagai, Kunitaka, Nii, Rikuto, Kishimoto, Nozomi, Yoshikawa, Yuki, Yata, Shinsaku, Fujii, Shinya, and Nishimura, Motonobu

Subjects
endovascular aneurysm repair, abdominal aortic aneurysm, Original Article, type II endoleak, General Medicine
Abstract

BACKGROUND: This study aimed to evaluate the effect of aggressive embolization of side branches arising from the aneurysmal sac before endovascular aneurysm repair. METHODS: This retrospective study included 95 patients who underwent endovascular infrarenal abdominal aortic aneurysm repair at Tottori University Hospital between October 2016 and January 2021. Of these, 54 underwent standard endovascular aneurysm repair (conventional group), and 41 underwent coiling of the inferior mesenteric and lumbar arteries before undergoing endovascular aneurysm repair (embolization group). The occurrence of type II endoleak, change in aneurysmal sac diameter, and reintervention rate due to type II endoleak during follow-up were evaluated. RESULTS: Compared to the conventional group, the embolization group had a significantly lower incidence of type II endoleak, more frequent aneurysmal sac shrinkage, and lower aneurysmal sac growth related to type II endoleak. CONCLUSION: Our results demonstrated the effectiveness of aggressive aneurysmal sac embolization before endovascular aneurysm repair to prevent type II endoleak and the consequent long-term aneurysmal sac enlargement.

Published
2023
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47. ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D

Author

Komura, Kazumasa, Yoshikawa, Yuki, Shimamura, Teppei, Chakraborty, Goutam, Gerke, Travis A., Hinohara, Kunihiko, Chadalavada, Kalyani, Jeong, Seong Ho, Armenia, Joshua, Du, Shin-Yi, Mazzu, Ying Z., Taniguchi, Kohei, Ibuki, Naokazu, Meyer, Clifford A., Nanjangud, Gouri J., Inamoto, Teruo, Lee, Gwo-Shu Mary, Mucci, Lorelei A., Azuma, Haruhito, Sweeney, Christopher J., and Kantoff, Philip W.

Subjects
DNA sequencing -- Usage, Antiretroviral agents -- Dosage and administration, Prostate cancer -- Care and treatment -- Risk factors, Health care industry
Abstract

Epigenetic modifications control cancer development and clonal evolution in various cancer types. Here, we show that loss of the male-specific histone demethylase lysine-specific demethylase 5D (KDM5D) encoded on the Y chromosome epigenetically modifies histone methylation marks and alters gene expression, resulting in aggressive prostate cancer. Fluorescent in situ hybridization demonstrated that segmental or total deletion of the Y chromosome in prostate cancer cells is one of the causes of decreased KDM5D mRNA expression. The result of ChIP-sequencing analysis revealed that KDM5D preferably binds to promoter regions with coenrichment of the motifs of crucial transcription factors that regulate the cell cycle. Loss of KDM5D expression with dysregulated H3K4me3 transcriptional marks was associated with acceleration of the cell cycle and mitotic entry, leading to increased DNA-replication stress. Analysis of multiple clinical data sets reproducibly showed that loss of expression of KDM5D confers a poorer prognosis. Notably, we also found stress-induced DNA damage on the serine/threonine protein kinase ATR with loss of KDM5D. In KDM5D-deficient cells, blocking ATR activity with an ATR inhibitor enhanced DNA damage, which led to subsequent apoptosis. These data start to elucidate the biological characteristics resulting from loss of KDM5D and also provide clues for a potential novel therapeutic approach for this subset of aggressive prostate cancer., Introduction Prostate cancer (PC) is the most common cancer among men in the United States and one of the leading causes of cancer death, with approximately 27,000 deaths per year [...]

Published
2018
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50. Patchworking Multiple Pairwise Distances for Learning with Distance Matrices

Author

Takano, Ken, Hino, Hideitsu, Yoshikawa, Yuki, Murata, Noboru, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Vincent, Emmanuel, editor, Yeredor, Arie, editor, Koldovský, Zbyněk, editor, and Tichavský, Petr, editor

Published
2015
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