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1,240 results on '"Yoshikawa, Tetsushi"'

1. Increase in Adult Patients with Varicella Zoster Virus--Related Central Nervous System Infections, Japan

Author

Yoshikane, Ayami, Miura, Hiroki, Shima, Sayuri, Matsunaga, Masaaki, Ishimaru, Soichiro, Higashimoto, Yuki, Kawamura, Yoshiki, Kozawa, Kei, Yoshikawa, Akiko, Ueda, Akihiro, Ota, Atsuhiko, Watanabe, Hirohisa, Mutoh, Tatsuro, and Yoshikawa, Tetsushi

Subjects
Shingles (Disease) -- Diagnosis -- Care and treatment -- Distribution, Viral vaccines -- Testing, Central nervous system diseases -- Diagnosis -- Care and treatment -- Distribution, Company distribution practices, Health
Abstract

Primary varicella zoster virus (VZV) infection can cause varicella (chicken pox), which is generally a mild, self-limiting disease; however, VZV infection can also rarely lead to serious complications, such as [...]

Published
2024
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4. Clinical Practice Guidelines for the Management of Congenital Cytomegalovirus Infection in Japan 2023: Executive Summary

Author

Ito, Yoshinori, Morioka, Ichiro, Takahashi, Naoto, Fujioka, Kazumichi, Miura, Kiyonori, Moriuchi, Hiroyuki, Morimoto, Noriko, Yoshikawa, Tetsushi, Ashina, Mariko, Abe, Shinya, Imafuku, Hitomi, Uchida, Akiko, Okahashi, Aya, Kakiuchi, Satsuki, Kakimoto, Yu, Kawata, Soichiro, Kawamura, Yoshiki, Kido, Takumi, Kidokoro, Hiroyuki, Kozawa, Kei, Samejima, Tomohiro, Suzuki, Takako, Tanimura, Kenji, Tomonaga, Chiharu, Torii, Yuka, Nakanishi, Megumi, Nagano, Nobuhiko, Nagamatsu, Takeshi, Narita, Hajime, Nishimura, Koji, Nonobe, Norie, Hasegawa, Yuri, Hara, Koichiro, Hijikata, Midori, Fukuda, Takuya, Funato, Yusuke, Mimura, Nobuko, Yamamoto, Nobuko, Yoshitomi, Ai, Kakei, Yasumasa, Kodama, Tomoyuki, and Oka, Akira

Published
2024
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8. Assessment of patients’ characteristics associated with the efficacy and safety of oral valganciclovir treatment for infants with symptomatic congenital cytomegalovirus disease

Author

Okahashi, Aya, Nagano, Nobuhiko, Hijikata, Midori, Fuwa, Kazumasa, Aoki, Ryoji, Seimiya, Ayako, Imaizumi, Takayuki, Akimoto, Takuya, Hara, Koichiro, Katayama, Daichi, Abe, Shinya, Ashina, Mariko, Nakasone, Ruka, Kyouno, Yuki, Takumi, Kido, Takenaka, Satoshi, Kakiuchi, Satsuki, Kakimoto, Yu, Kozawa, Kei, Funato, Yusuke, Miura, Hiroki, Kawamura, Yoshiki, Ogata, Tsutomu, Nakashima, Yumiko, Kawada, Jun-ichi, Torii, Yuka, Suzuki, Takako, Fukuda, Yuto, Haruta, Kazunori, Yamaguchi, Makoto, Masaaki, Teranishi, Kakei, Yasumasa, Morioka, Ichiro, Imai, Takumi, Itohara, Kotaro, Yano, Ikuko, Takahashi, Naoto, Yoshikawa, Tetsushi, Moriuchi, Hiroyuki, Ito, Yoshinori, Fujioka, Kazumichi, and Oka, Akira

Published
2024
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10. Meningitis Caused by the Live Varicella Vaccine Virus: Metagenomic Next Generation Sequencing, Immunology Exome Sequencing and Cytokine Multiplex Profiling

Author

Ramachandran, Prashanth S, Wilson, Michael R, Catho, Gaud, Blanchard-Rohner, Geraldine, Schiess, Nicoline, Cohrs, Randall J, Boutolleau, David, Burrel, Sonia, Yoshikawa, Tetsushi, Wapniarski, Anne, Heusel, Ethan H, Carpenter, John E, Jackson, Wallen, Ford, Bradley A, and Grose, Charles

Subjects
Infectious Diseases, Vaccine Related, Biotechnology, Immunization, Clinical Research, Prevention, Genetics, Aetiology, Prevention of disease and conditions, and promotion of well-being, 3.4 Vaccines, 2.1 Biological and endogenous factors, Infection, Good Health and Well Being, Adolescent, Biomarkers, Chickenpox Vaccine, Child, Cytokines, Female, Herpes Zoster, High-Throughput Nucleotide Sequencing, Humans, Immunocompetence, Male, Meningitis, Viral, Metagenomics, Exome Sequencing, varicella-zoster virus, Oka strain, human herpesvirus 6, human herpesvirus 7, corticosteroids, serious adverse event, herpes zoster, IL-6, IL-10, innate immunity, Microbiology
Abstract

Varicella vaccine meningitis is an uncommon delayed adverse event of vaccination. Varicella vaccine meningitis has been diagnosed in 12 children, of whom 3 were immunocompromised. We now report two additional cases of vaccine meningitis in twice-immunized immunocompetent children and we perform further testing on a prior third case. We used three methods to diagnose or investigate cases of varicella vaccine meningitis, none of which have been used previously on this disease. These include metagenomic next-generation sequencing and cytokine multiplex profiling of cerebrospinal fluid and immunology exome analysis of white blood cells. In one new case, the diagnosis was confirmed by metagenomic next-generation sequencing of cerebrospinal fluid. Both varicella vaccine virus and human herpesvirus 7 DNA were detected. We performed cytokine multiplex profiling on the cerebrospinal fluid of two cases and found ten elevated biomarkers: interferon gamma, interleukins IL-1RA, IL-6, IL-8, IL-10, IL-17F, chemokines CXCL-9, CXCL-10, CCL-2, and G-CSF. In a second new case, we performed immunology exome sequencing on a panel of 356 genes, but no errors were found. After a review of all 14 cases, we concluded that (i) there is no common explanation for this adverse event, but (ii) ingestion of an oral corticosteroid burst 3-4 weeks before onset of vaccine meningitis may be a risk factor in some cases.

Published
2021

18. Acute and Postacute Clinical Characteristics of Coronavirus Disease 2019 in Children in Japan

Author

Katsuta, Tomohiro, Aizawa, Yuta, Shoji, Kensuke, Shimizu, Naoki, Okada, Kenji, Nakano, Takashi, Kamiya, Hajime, Amo, Kiyoko, Ishiwada, Naruhiko, Iwata, Satoshi, Oshiro, Makoto, Okabe, Nobuhiko, Korematsu, Seigo, Suga, Shigeru, Tsugawa, Takeshi, Nishimura, Naoko, Hishiki, Haruka, Fujioka, Masashi, Hosoya, Mitsuaki, Mizuno, Yumi, Miyairi, Isao, Miyazaki, Chiaki, Morishima, Tsuneo, Yoshikawa, Tetsushi, Wada, Taizo, Ouchi, Kazunobu, Moriuchi, Hiroyuki, Tanaka-Taya, Keiko, and Saitoh, Akihiko

Published
2022
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22. Full genome-based characterization of G4P[6] rotavirus strains from diarrheic patients in Thailand: Evidence for independent porcine-to-human interspecies transmission events

Author

Tacharoenmuang, Ratana, Guntapong, Ratigorn, Upachai, Sompong, Singchai, Phakapun, Fukuda, Saori, Ide, Tomihiko, Hatazawa, Riona, Sutthiwarakom, Karun, Kongjorn, Santip, Onvimala, Napa, Luechakham, Tipsuda, Ruchusatsawast, Kriangsak, Kawamura, Yoshiki, Sriwanthana, Busarawan, Motomura, Kazushi, Tatsumi, Masashi, Takeda, Naokazu, Yoshikawa, Tetsushi, Murata, Takayuki, Uppapong, Ballang, Taniguchi, Koki, and Komoto, Satoshi

Published
2021
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24. Elevated cerebrospinal fluid IgG index in herpes simplex encephalitis post‐HSV‐1 clearance: A preliminary study.

Author

Asakura, Mao, Mizutani, Yasuaki, Shima, Sayuri, Kawamura, Yoshiki, Ueda, Akihiro, Ito, Mizuki, Mutoh, Tatsuro, Yoshikawa, Tetsushi, and Watanabe, Hirohisa

Subjects
HUMAN herpesvirus 1, HERPES simplex, HERPES simplex virus, CEREBROSPINAL fluid, IMMUNOGLOBULIN G, CHICKENPOX
Abstract

Herpes simplex encephalitis (HSE) is an acute form of encephalitis that can lead to poor neurological outcomes. Although the exact pathogenesis of HSE remains elusive, recent reports suggest a significant role for postinfectious immune‐inflammatory processes in the central nervous system (CNS). This study aimed to clarify the association between CNS autoimmune responses and clinical presentation in patients with HSE, focusing on cerebrospinal fluid (CSF) characteristics, particularly the IgG index. We retrospectively analyzed 176 consecutive patients suspected of having aseptic meningitis /encephalitis for chronological changes in CSF findings and clinical presentations. These patients underwent PCR screening for herpesviruses (HV) in their CSF. We identified seven patients positive for herpes simplex virus type 1 (HSV‐1), 20 patients positive for varicella‐zoster virus, and 17 patients who met the criteria for aseptic meningitis but were PCR‐negative for HV. Patients in the HSV‐1‐positive group exhibited a significant increase in the IgG index at the time of PCR‐negative conversion compared with on admission (p = 0.0156), while such a change was not observed in the other two groups. Additionally, all patients in the HSV‐1‐positive group tested negative for anti‐neural autoantibodies in CSF and serum samples collected approximately 3 weeks after onset. This study, therefore, highlights that CSF IgG index elevation occurs even after PCR‐confirmed HSV‐1 clearance, which might indicate immunopathogenesis that is independent of antibody‐mediated mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Temporal patterns of asymptomatic SARS‐CoV‐2 infection among pediatric population in Japan: A 3‐year analysis.

Author

Kozawa, Kei, Higashimoto, Yuki, Kawamura, Yoshiki, Miura, Hiroki, Hattori, Fumihiko, Mihara, Yuka, Nakai, Hidetaka, Nishimura, Naoko, Ozaki, Takao, Ihira, Masaru, and Yoshikawa, Tetsushi

Subjects
COVID-19, SARS-CoV-2 Omicron variant, CHILD patients, JAPANESE people, SEROPREVALENCE
Abstract

To elucidate the seroprevalence and rate of asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in Japanese children, serological analysis was performed using serum samples collected from March 2020 to February 2023. A total of 1493 serum samples were collected during the first study period (March 2020 to February 2021). None of the serum samples was positive for SARS‐CoV‐2 antibody. In the second period (March 2021 to February 2022), seven of the 1055 patients (0.7%) experienced SARS‐CoV‐2 infection. The third period (March 2022 to February 2023) was divided into three terms: from March to June 30, 2022; from July to October 2022; and from November 2022 to February 2023. The seroprevalence gradually increased throughout this period, with rates of 6.0%, 18.6%, and 30.4% in the three terms, respectively. Pediatric cases of asymptomatic SARS‐CoV‐2 infection occurred after the surge of Omicron variants. Since none of the SARS‐CoV‐2 antibody‐positive patients had a previous history of coronavirus disease 2019, the seroprevalence rate in this study may represent the rate of asymptomatic infection. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Generation of Recombinant Authentic Live Attenuated Human Rotavirus Vaccine Strain RIX4414 (Rotarix ®) from Cloned cDNAs Using Reverse Genetics.

Author

Fukuda, Saori, Kugita, Masanori, Kumamoto, Kanako, Akari, Yuki, Higashimoto, Yuki, Nagao, Shizuko, Murata, Takayuki, Yoshikawa, Tetsushi, Taniguchi, Koki, and Komoto, Satoshi

Subjects
ROTAVIRUS vaccines, WHOLE genome sequencing, ROTAVIRUSES, RECOMBINANT viruses, REVERSE genetics, CELL culture, INFANTS
Abstract

The live attenuated human rotavirus vaccine strain RIX4414 (Rotarix®) is used worldwide to prevent severe rotavirus-induced diarrhea in infants. This strain was attenuated through the cell culture passaging of its predecessor, human strain 89-12, which resulted in multiple genomic mutations. However, the specific molecular reasons underlying its attenuation have remained elusive, primarily due to the absence of a suitable reverse genetics system enabling precise genetic manipulations. Therefore, we first completed the sequencing of its genome and then developed a reverse genetics system for the authentic RIX4414 virus. Our experimental results demonstrate that the rescued recombinant RIX4414 virus exhibits biological characteristics similar to those of the parental RIX4414 virus, both in vitro and in vivo. This novel reverse genetics system provides a powerful tool for investigating the molecular basis of RIX4414 attenuation and may facilitate the rational design of safer and more effective human rotavirus vaccines. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Assessment of patients’ characteristics associated with the efficacy and safety of oral valganciclovir treatment for infants with symptomatic congenital cytomegalovirus disease

Author

Kakei, Yasumasa, primary, Morioka, Ichiro, additional, Imai, Takumi, additional, Itohara, Kotaro, additional, Yano, Ikuko, additional, Takahashi, Naoto, additional, Yoshikawa, Tetsushi, additional, Moriuchi, Hiroyuki, additional, Ito, Yoshinori, additional, Fujioka, Kazumichi, additional, Oka, Akira, additional, Okahashi, Aya, additional, Nagano, Nobuhiko, additional, Hijikata, Midori, additional, Fuwa, Kazumasa, additional, Aoki, Ryoji, additional, Seimiya, Ayako, additional, Imaizumi, Takayuki, additional, Akimoto, Takuya, additional, Hara, Koichiro, additional, Katayama, Daichi, additional, Abe, Shinya, additional, Ashina, Mariko, additional, Nakasone, Ruka, additional, Kyouno, Yuki, additional, Takumi, Kido, additional, Takenaka, Satoshi, additional, Kakiuchi, Satsuki, additional, Kakimoto, Yu, additional, Kozawa, Kei, additional, Funato, Yusuke, additional, Miura, Hiroki, additional, Kawamura, Yoshiki, additional, Ogata, Tsutomu, additional, Nakashima, Yumiko, additional, Kawada, Jun-ichi, additional, Torii, Yuka, additional, Suzuki, Takako, additional, Fukuda, Yuto, additional, Haruta, Kazunori, additional, Yamaguchi, Makoto, additional, and Masaaki, Teranishi, additional

Published
2024
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30. A novel UBA1 gene mutation in a patient with infantile respiratory distress syndrome.

Author

Miyata, Masafumi, Kojima, Arisa, Kawai, Yuri, Uchida, Hidetoshi, Boda, Hiroko, Ishihara, Naoko, Inagaki, Hidehito, Yoshikawa, Tetsushi, and Kurahashi, Hiroki

Subjects
RESPIRATORY distress syndrome, SPINAL muscular atrophy, LIFE sciences, CYTOLOGY, MISSENSE mutation, X chromosome
Abstract

UBA1 is an E1 ubiquitin-activating enzyme that initiates the ubiquitylation of target proteins and is thus a key component of the ubiquitin signaling pathway. Three disorders are associated with pathogenic variants of the UBA1 gene: vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome, lung cancer in never smokers (LCINS), and X-linked spinal muscular atrophy (XL-SMA, SMAX2). We here report a case of infantile respiratory distress syndrome followed by continuing neuromuscular symptoms. We identified a de novo hemizygous mutation, c.1660 C > T (p.Pro554Ser), in exon 15 of the UBA1 gene in this baby. This missense mutation was located with the AAD (active adenylation domain) of the protein, a known hotspot of SMAX2 mutations. This case lends support to the genotype-phenotype correlation regarding the UBA1 mutation and its related diseases. [ABSTRACT FROM AUTHOR]

Published
2025
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37. Analysis of cytokine profiles in pediatric fulminant myocarditis and acute myocarditis multicenter study

Author

Nomura, Yoji, primary, Suzuki, Takanori, additional, Kunida, Katsuyuki, additional, Uchida, Hidetoshi, additional, Ito, Ryoichi, additional, Oshima, Yasunori, additional, Kito, Machiko, additional, Imai, Yuki, additional, Kawai, Satoru, additional, Kozawa, Kei, additional, Saito, Kazuyoshi, additional, Hata, Tadayoshi, additional, Yoshimoto, Junichiro, additional, Yoshikawa, Tetsushi, additional, and Yasuda, Kazushi, additional

Published
2023
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43. Defective Epstein–Barr virus in chronic active infection and haematological malignancy

Author

Okuno, Yusuke, Murata, Takayuki, Sato, Yoshitaka, Muramatsu, Hideki, Ito, Yoshinori, Watanabe, Takahiro, Okuno, Tatsuya, Murakami, Norihiro, Yoshida, Kenichi, Sawada, Akihisa, Inoue, Masami, Kawa, Keisei, Seto, Masao, Ohshima, Koichi, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Miyano, Satoru, Narita, Yohei, Yoshida, Masahiro, Goshima, Fumi, Kawada, Jun-ichi, Nishida, Tetsuya, Kiyoi, Hitoshi, Kato, Seiichi, Nakamura, Shigeo, Morishima, Satoko, Yoshikawa, Tetsushi, Fujiwara, Shigeyoshi, Shimizu, Norio, Isobe, Yasushi, Noguchi, Masaaki, Kikuta, Atsushi, Iwatsuki, Keiji, Takahashi, Yoshiyuki, Kojima, Seiji, Ogawa, Seishi, and Kimura, Hiroshi

Published
2019
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45. Development of recombinant rotavirus carrying herpes simplex virus 2 glycoprotein D gene based on reverse genetics technology.

Author

Kawamura, Yoshiki, Komoto, Satoshi, Fukuda, Saori, Kugita, Masanori, Tang, Shuang, Patel, Amita, Pieknik, Julianna R., Nagao, Shizuko, Taniguchi, Koki, Krause, Philip R., and Yoshikawa, Tetsushi

Subjects
HERPES simplex virus, REVERSE genetics, BASE pairs, HERPES genitalis, ROTAVIRUSES, GENETIC vectors
Abstract

Vaccine development for herpes simplex virus 2 (HSV‐2) has been attempted, but no vaccines are yet available. A plasmid‐based reverse genetics system for Rotavirus (RV), which can cause gastroenteritis, allows the generation of recombinant RV containing foreign genes. In this study, we sought to develop simian RV (SA11) as a vector to express HSV‐2 glycoprotein D (gD2) and evaluated its immunogenicity in mice. We generated the recombinant SA11‐gD2 virus (rSA11‐gD2) and confirmed its ability to express gD2 in vitro. The virus was orally inoculated into suckling BALB/c mice and into 8‐week‐old mice. Serum IgG and IgA titers against RV and gD2 were measured by ELISA. In the 8‐week‐old mice inoculated with rSA11‐gD2, significant increases in not only antibodies against RV but also IgG against gD2 were demonstrated. In the suckling mice, antibodies against RV were induced, but gD2 antibody was not detected. Diarrhea observed after the first inoculation of rSA11‐gD2 in suckling mice was similar to that induced by the parent virus. A gD2 expressing simian RV recombinant, which was orally inoculated, induced IgG against gD2. This strategy holds possibility for genital herpes vaccine development. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Atresia of the right coronary arterial ostium with a left ventricular fistula: A case report

Author

Suzuki, Takanori, Miyagawa-Tomita, Sachiko, Saito, Kazuyoshi, Yoshikawa, Tetsushi, Kawai, Satoru, and Yasuda, Kazushi

Subjects
Case Report, Cardiology and Cardiovascular Medicine
Abstract

We describe the case of a young patient with atresia of the right coronary arterial ostium with left ventricular fistula. This was suspected from the abnormality detected on a 12‑lead electrocardiogram (ECG) during a school examination at the time of admission to junior high school and echocardiography findings. This disease may occur due to abnormalities in several molecules that are essential for coronary artery development. In cases of ECG abnormality, and unexplained aortic valve regurgitation and coronary artery abnormalities on echocardiography are detected, this disease should be suspected. LEARNING OBJECTIVE: Coronary artery anomalies have been identified in coronary angiograms. Herein, we describe the case of a young patient with atresia of the right coronary arterial ostium with left ventricular fistula. This disease may be caused by abnormalities in several molecules that are essential molecule for coronary artery development.

Published
2022
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