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1. The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury)

Author

Takigami, Masayoshi, Kamiyama, Kenji, Houkin, Kiyohiro, Nishi, Shougo, Yoshimoto, Tetsuyuki, Kaneko, Sadao, Oka, Koji, Ooyama, Hiroshi, Kamada, Kyousuke, Makino, Kenichi, Tokumitsu, Naoki, Sako, Kazuhiro, Suzuki, Susumu, Suzuki, Nozomi, Izumi, Naoto, Nitta, Kazumi, Ootaki, Masahumi, Isobe, Masanori, Nishiya, Mikio, Yamazaki, Takaaki, Mabuchi, Syouji, Ogasawara, Kuniaki, Kubo, Naohiko, Shimizu, Yukihiko, Saito, Keiichi, Yamanome, Tatumi, Yoshino, Atsuo, Fujitsuka, Mitsuyuki, Takami, Masaaki, Ohtaka, Hirotoshi, Hirano, Teruyuki, Shiokawa, Yosiaki, Okada, Takaharu, Suzuki, Ichiro, Kohno, Michihiro, Haraoka, Jou, Arai, Yoshinori, Kawamura, Noriyoshi, Isoshima, Akira, Yasue, Masaharu, Takayoshi Kobayashi, Mitsuhiko Hokari, Kawai, Kensuke, Maehara, Taketoshi, Arai, Hajime, Noguchi, Makoto, Hoshino, Haruhiko, Hiyama, Hirofumi, Yoshida, Kensaku, Utsugi, Osamu, Takeda, Yasuaki, Tamaki, Kouichi, Karasudani, Hirohide, Urabe, Takao, Kobayashi, Shiro, Nakamura, Michio, Koguchi, Yorio, Ono, Junichi, Suda, Sumio, Hadeishi, Hiromu, Fukutake, Toshio, Wakui, Kenji, Tanno, Hirokazu, Ishige, Naoki, Ohasi, Takashi, Sakai, Hideki, Nishimura, Yasuaki, Watanabe, Takayuki, Matsumoto, Takashi, Koketsu, Naoki, Hirose, Yuichi, Doyu, Manabu, Hasegawa, Toshinori, Kuwayama, Naoto, Terao, Shinichi, Mizutani, Nobuhiko, Suzaki, Noriyuki, Okuda, Satoshi, Yasui, Keizo, Seki, Yukio, Hasegawa, Yasuhiro, Ikeda, Akira, Takeuchi, Youtarou, Ohara, Sigeki, Araki, Yoshio, Wakabayashi, Toshihiko, Tanaka, Hisashi, Yoshimoto, Junpei, Sugiura, Makoto, Koichiro, Ogura, Kobayashi, Nozomu, Yamada, Tomonori, Kato, Amami, Toshiho, Ohtsuki, Wakayama, Akatsuki, Takahashi, Jun, Kataoka, Hiroharu, Yoshimine, Toshiki, Nakajima, Yoshikazu, Gi, Hidehuku, Uranishi, Ryunosuke, Nakamura, Yusaku, Yamanaka, Kazunori, Ohmori, Kazumi, Matsumoto, Hiroyuki, Oiwa, Yoshitugu, Uemura, Yosihiko, Fujiwara, Hiroaki, Iwai, Yoshiyasu, Morikawa, Masashi, Tane, Kazuyuki, Hashikawa, Kazuo, Fujinaka, Toshiyuki, Yoneda, Shunichi, Yamashita, Kohsuke, Kitano, Masahiko, Tominaga, Shinsuke, Nakamura, Kazuhito, Kono, Katsuhiko, Ohata, Kenji, Taniguchi, Hirokatsu, Hazama, Takanori, Kuroiwa, Toshihiko, Tamura, Yoji, Maeno, Kazusige, Arai, Motohiro, Iwase, Masaaki, Hashimoto, Kenji, Yamada, Keisuke, Turuno, Takashi, Ichinose, Tsutomu, Kurokawa, Shinichiro, Matsuyama, Takeshi, Fujita, Toshiaki, Yuguchi, Takamichi, Teramoto, Yoshihumi, Kakita, Hiroto, Matsuo, Takayuki, Izumo, Tsuyoshi, Ryu, Nobutoshi, Naoki Kitagawa, Wataru Haraguchi, Kaminogo, Makio, Sakamoto, Seisaburo, Tokunaga, Yosiharu, Urasaki, Ei-Ichirou, Kuratsu, Junichi, Takada, Akira, Terasaki, Tadashi, Hisami Oosima, Isao Fuwa, Yamashiro, Shigeo, Hiromasa Tsuiki, Makoto Yoshikawa, Koga, Kazunari, Egami, Hiroshi, Kawamura, Tadao, Mitsuo, Kunihiko, Masaki Morisige, Takamitu Hikawa, Takeda, Yuu, Yamaguchi, Yutaka, Shunro Uchinokura, Shiro Miyata, Goya, Tomokazu, Takeshima, Hideo, Yatsushiro, Kazutaka, Ohta, Hajime, Nagadou, Tatsui, Hirahara, Kazuho, Obara, Souichi, Seto, Hiroshi, Moroki, Koiti, Arita, Kazunori, Ishiuchi, Shogo, Uchihara, Toshimitsu, Mekaru, Susumu, Nagamine, Tomoaki, Jin Momoji, Naoki Tomiyama, Atusi Kimoto, Kouzi Idomari, Kadekaru, Tsutomu, Syamoto, Hirosi, Sasaki, Osamu, Minagawa, Makoto, Takahashi, Hideaki, Hiroyuki Arai, Kiyoshi Onda, Takeuchi, Shigekazu, Abe, Hiroshi, Fukuda, Osamu, Kouno, Mitsuo, Tamura, Tetsuro, Michiya Kubo, Yukio Horie, Hondo, Hiroaki, Takada, Hisashi, Masuoka, Toru, Shirasaki, Naoki, Nitta, Hisashi, Yasuo Katsuki, Makoto Kimura, Hisato Minamide, Yutaka Hayashi, Munemoto, Shigeru, Ikeda, Kiyonobu, Yutaka Hayashi, Mitsutoshi Nakada, Sato, Syuji, Hatano, Taketo, Yamamura, Osamu, Kabuto, Masanori, Jyunya Hayashi, Takahiro Sakuma, Kinouchi, Hiroyuki, Koizumi, Hidehito, Imae, Syougo, Fujita, Manabu, Suga, Masakazu, Kanehisa Kohno, Shinji Iwata, Zenke, Kiichiro, Fujisawa, Mutsuo, Mizobuchi, Hikaru, Hayashi, Satoru, Morimoto, Masanori, Ueba, Tetsuya, Nishimura, Hiroyuki, Ikawa, Naoki, Matsumoto, Yuzo, Kannuki, Seiji, Kagawa, Masahiro, Hayashi, Naoki, Atsushi Shindo, Takashi Tamiya, Yoshino, Kimihiro, Masaoka, Tetsuya, Nakahara, Ichiro, Satoshi Suzuki, Akira Nakamizo, Okamoto, Yuji, Takahashi, Haruki, Iihara, Koji, Hirakawa, Katsuyuki, Nagata, Shinji, Ookura, Akio, Yoshiro Kaneko, Hidenori Yoshida, Nakane, Hiroshi, Inoue, Isao, Hitotsumatsu, Tsutomu, Kouichi Kuramoto, Terukazu Kuramoto, Hiromichi Ooishi, Yoshihisa Matumoto, Masani Nonaka, Tooru Inoue, Morioka, Motohiro, Shuji Sakata, Hiroshi Sugimori, Takashima, Hiroshi, Ishihara, Shin-Ichiro, Suzuyama, Kenji, Miyazono, Masayuki, Itaro Hattori, Masafumi Morimoto, Ozaki, Satoshi, Hirota, Nobuo, Yasuhiko Mochimatsu, Yasunori Takemoto, Takagi, Makoto, Kenji Nakayama, Isao Yamamoto, Hiroshi Tanaka, Yoshinori Uchida, Sakata, Katsumi, Nobutaka, Kawahara, Nomura, Motohiro, Ozawa, Hitoshi, Tsumura, Kotaro, Michiyuki Maruyama, Makoto Inaba, Mori, Tatsuro, Mori, Takahisa, Sugitani, Masato, Tanaka, Yuichiro, Yamada, Masaru, Matsumae, Mitsunori, Onitsuka, Keiichirou, Tatsuya Takahashi, Kosuke Miyahara, Endou, Sumio, Takahashi, Hidekazu, Kaidu, Hiroyuki, Chikashi Maruki, Akira Tsunoda, Fujimaki, Takamitsu, Ooigawa, Hidetoshi, Masatsugu Uchida, Masahiko Tanaka, Kouiti Katoh, Hiroshi Wanihuti, Hyodo, Akio, Asakura, Ken, Nakajima, Shigeyoshi, Kanzawa, Takao, Kurihara, Hideyuki, Ohmori, Sigehiro, Hiroshi Kusunoki, Mitsugi Yoshinao, Magarisawa, Satoshi, Okabe, Shinichi, Kujiraoka, Yuuji, Tsuruoka, Shin, Takeshita, Mikihiko, Akira Matsumura, Tetsuya Yamamoto, Uemura, Kazuya, Tabata, Hitoshi, Sonobe, Makoto, Ryoji Yoshida, Masashi Nakatsukasa, Shimoeda, Norifumi, Kunimine, Hideo, Ishihara, Masayuki, Murai, Nozomu, Murakami, Nobukuni, Kidooka, Minoru, Iwamoto, Yoshihiro, Tenjin, Hiroshi, Masahiko Takamasu, Kouji Shiga, Mori, Nobuhito, Kose, Shigeru, Kohmura, Eiji, Matsumoto, Keigo, Sakaki, Takayuki, Miyake, Hiroji, Mabuchi, Eiichiro, Yokota, Masayuki, Yosihiro Kuga, Hideyuki Ohnishi, Kimura, Mitsuru, Masaaki Saiki, Osamu Narumi, Nakajima, Norio, Asahi, Minoru, Koyama, Junji, Noda, Shinya, Iida, Junichi, Fujita, Toyohisa, Nakase, Hiroyuki, Toru Hoshida, Hidehiro Hirabayashi, Fujimoto, Takayoshi, Nakao, Naoyuki, Tanaka, Yoshiyuki, Ozaki, Fuminori, Nakamura, Yoshinari, Miki, Kazuhito, Watanabe, Takashi, Hasegawa, Seiko, Konno, Hiromu, Takemura, Atsuhito, Okubo, Atsuya, Saito, Hitoshi, Taizen Nakase, Tatsuya Ishikawa, Toshio Sasajima, Hiroaki Shimizu, Sasou, Masayuki, Watanabe, Yoichi, Kiyoshi Saito, Taku Sato, Masahiro Satoh, Satoshi Taira, Koizumi, Takayuki, Shoji Mashiyama, Yasuhiro Suzuki, Oikawa, Tomoyoshi, Sonoda, Yukihiko, Shinjiro Saito, Rei Kondo, Shinoda, Atsuo, Kamatsuka, Eiichiro, So, Keiten, Kinjo, Toshihiko, Kennji Itou, Tooru Sasaki, Hiroaki Shimizu, Hidenori Endo, Karibe, Hirosi, Takahashi, Kou, Nakajima, Masayuki, Watanabe, Kazuyoshi, Takayama, Motohiro, Komuro, Taro, Fumio Suzuki, Hisao Hirai, Suzuki, Hidenori, Murata, Hiroto, Miya, Fumitaka, Kanamaru, Kenji, Tamura, Akira, Harada, Kiyoshi, Fukazawa, Seiji, Takehara, Seiya, Watanabe, Yoshihiko, Nakayama, Teiji, Hiroshi Nagura, Haruhiko Sato, Chiharu Tanoi, Shinji Amano, Kuroda, Katsuhiro, Morooka, Satoru, Masashi Kitagawa, Takafumi Wataya, Koide, Kazuo, Tanigawara, Tetsuya, Iwama, Toru, Ito, Junki, Noda, Shinji, Kouno, Kazuyuki, Kitazawa, Kazuo, Toshiki Takemae, Yoshikazu Kusano, Hokama, Masanobu, Yoshihisa Nishiyama, Hiroki Sato, Seguchi, Tatsuya, Yoshihiko Inui, Sumio Kobayashi, Oohigashi, Youji, Muraoka, Shinsuke, Miyatake, Masaki, Nakagawa Shinichi, Kensuke Hayashida, Inoue, Atsushi, Sakai, Keiichi, Yamaguchi, Shuhei, Fusao Ikawa, Tatsuya Mizoue, Hideki Irie, Gen Ishida, Kagawa, Takato, Namba, Yoichiro, Nakashima, Hiroyuki, Koji Abe, Isao Date, Uno, Masaaki, Sen Yamagata, Masaki Chin, Soitiro Takao, Hidemiti Sasayama, Kouji Muneda, Hideyuki Yoshida, Watanebe, Akira, Katou, Syouichi, Hamada, Yasuhiro, Suzuki, Michiyasu, Nishizaki, Takafumi, Yamashita, Katsuhiro, Ryuji Nakamura, Takaharu Nakamura, Wakabayashi, Shinichi, Okazaki, Takahito, Kurisu, Kaoru, Matsumoto, Masayasu, Katsuzo Kiya, Atsushi Tominaga, Syuichi Oki, Masaaki Shibukawa, Nakahara, Toshinori, Okita, Shinji, Torii, Tuyosi, Kenjirou Fujiwara, Minoru Nakagawa, Syuuhei Nishimura, Takashi Matsuoka, Naoyuki Isobe, Osamu Hamasaki, Shinji Nagahiro, Junichiro Satomi, Agawa, Masahito, Oka, Hirofumi, Yoshimura, Kunikazu, Kato, Tsutomu, Satoshi Minoshima, Nobuaki Kobayasi, Mikuni, Nobuhiro, Tanikawa, Rokuya, Sasaki, Jyunkou, Otawara, Yasunari, Tominaga, Teiji, Sasaki, Tatsuya, Takemura, Sunao, Kawakami, Masahisa, Ihara, Satoshi, Shibata, Yasushi, Saegusa, Takashi, Iuchi, Toshihiko, Ito, Chiaki, Okuda, Osamu, Yoshida, Kazunari, Masateru Katayama, Sadao Suga, Akihiro, Oikawa, Miura, Naohisa, Ota, Takahiro, Kumabe, Toshihiro, Suzuki, Sachio, Kumagai, Takashi, Nishimaki, Keiichi, Hongo, Kazuhiro, Shigeta, Hiroaki, Hattori, Kazuyoshi, Uozumi, Yoichi, Nakahara, Norimoto, Hashimoto, Nobukazu, Shu Imai, Shinichi Shirakami, Okumura, Yoshinari, Kazuhiro Yokoyama, Ryo Tamaki, Miyamoto, Susumu, Yamamoto, Kazuo, Ichioka, Tsugumichi, Inoue, Tsuyoshi, Kinoshita, Manabu, Saitoh, Minoru, Aihara, Hideo, Miyake, Hajimu, Tukasa Nishiura, Kotaro Ogihara, Nishino, Shigeki, Miyoshi, Yasuyuki, Arisawa, Tadashi, Shoji Tsuchimoto, Shigeru Daido, Kinoshita, Kimihisa, Keisuke Migita, Kiyoshi Yuki, Akatsuka, Keiichi, Fujisawa, Hirosuke, Shono, Tadahisa, Tsugu, Hitoshi, Hayashi, Shuji, Toshio Matsushima, Tatsuya Abe, Nakashima, Susumu, Tuji, Takehisa, Kaga, Akihiko, Kanemaru, Reizou, Takasaki, Koji, Imamura, Junichi, Noha, Masahiro, Watanabe, Saburo, Sakai, Nobuyuki, Hiroaki Minami, Yasuhisa Yoshida, Okumura, Tomoyoshi, Nishimura, Shinjitsu, Numazawa, Shinichi, Masanori Tsutsumi, Kiyoshi Kazekawa, Fukuyama, Kouzou, Fujimoto, Yasuhiro, Yamagami, Keitaro, Kurogi, Ryota, Kurogi, Ai, Nishimura, Kunihiro, Onozuka, Daisuke, Ren, Nice, Kada, Akiko, Nishimura, Ataru, Arimura, Koichi, Ido, Keisuke, Mizoguchi, Masahiro, Sakamoto, Tetsuya, Kayama, Takamasa, and Hagihara, Akihito

Published
2019
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3. The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury)

Author

Keitaro Yamagami, Ryota Kurogi, Ai Kurogi, Kunihiro Nishimura, Daisuke Onozuka, Nice Ren, Akiko Kada, Ataru Nishimura, Koichi Arimura, Keisuke Ido, Masahiro Mizoguchi, Tetsuya Sakamoto, Takamasa Kayama, Michiyasu Suzuki, Hajime Arai, Akihito Hagihara, Koji Iihara, Masayoshi Takigami, Kenji Kamiyama, Kiyohiro Houkin, Shougo Nishi, Tetsuyuki Yoshimoto, Sadao Kaneko, Koji Oka, Hiroshi Ooyama, Kyousuke Kamada, Kenichi Makino, Naoki Tokumitsu, Kazuhiro Sako, Susumu Suzuki, Nozomi Suzuki, Naoto Izumi, Kazumi Nitta, Masahumi Ootaki, Masanori Isobe, Mikio Nishiya, Takaaki Yamazaki, Syouji Mabuchi, Kuniaki Ogasawara, Naohiko Kubo, Yukihiko Shimizu, Keiichi Saito, Tatumi Yamanome, Atsuo Yoshino, Mitsuyuki Fujitsuka, Masaaki Takami, Hirotoshi Ohtaka, Teruyuki Hirano, Yosiaki Shiokawa, Takaharu Okada, Ichiro Suzuki, Michihiro Kohno, Jou Haraoka, Yoshinori Arai, Noriyoshi Kawamura, Akira Isoshima, Masaharu Yasue, Mitsuhiko Hokari Takayoshi Kobayashi, Kensuke Kawai, Taketoshi Maehara, Makoto Noguchi, Haruhiko Hoshino, Hirofumi Hiyama, Kensaku Yoshida, Osamu Utsugi, Yasuaki Takeda, Kouichi Tamaki, Hirohide Karasudani, Takao Urabe, Shiro Kobayashi, Michio Nakamura, Yorio Koguchi, Junichi Ono, Sumio Suda, Hiromu Hadeishi, Toshio Fukutake, Kenji Wakui, Hirokazu Tanno, Naoki Ishige, Takashi Ohasi, Hideki Sakai, Yasuaki Nishimura, Takayuki Watanabe, Takashi Matsumoto, Naoki Koketsu, Yuichi Hirose, Manabu Doyu, Toshinori Hasegawa, Naoto Kuwayama, Shinichi Terao, Nobuhiko Mizutani, Noriyuki Suzaki, Satoshi Okuda, Keizo Yasui, Yukio Seki, Yasuhiro Hasegawa, Akira Ikeda, Youtarou Takeuchi, Sigeki Ohara, Yoshio Araki, Toshihiko Wakabayashi, Hisashi Tanaka, Junpei Yoshimoto, Makoto Sugiura, Ogura Koichiro, Nozomu Kobayashi, Tomonori Yamada, Amami Kato, Ohtsuki Toshiho, Akatsuki Wakayama, Jun Takahashi, Hiroharu Kataoka, Toshiki Yoshimine, Yoshikazu Nakajima, Hidehuku Gi, Ryunosuke Uranishi, Yusaku Nakamura, Kazunori Yamanaka, Kazumi Ohmori, Hiroyuki Matsumoto, Yoshitugu Oiwa, Yosihiko Uemura, Hiroaki Fujiwara, Yoshiyasu Iwai, Masashi Morikawa, Kazuyuki Tane, Kazuo Hashikawa, Toshiyuki Fujinaka, Shunichi Yoneda, Kohsuke Yamashita, Masahiko Kitano, Shinsuke Tominaga, Kazuhito Nakamura, Katsuhiko Kono, Kenji Ohata, Hirokatsu Taniguchi, Takanori Hazama, Toshihiko Kuroiwa, Yoji Tamura, Kazusige Maeno, Motohiro Arai, Masaaki Iwase, Kenji Hashimoto, Keisuke Yamada, Takashi Turuno, Tsutomu Ichinose, Shinichiro Kurokawa, Takeshi Matsuyama, Toshiaki Fujita, Takamichi Yuguchi, Yoshihumi Teramoto, Hiroto Kakita, Takayuki Matsuo, Tsuyoshi Izumo, Nobutoshi Ryu, Wataru Haraguchi Naoki Kitagawa, Makio Kaminogo, Seisaburo Sakamoto, Yosiharu Tokunaga, Ei-Ichirou Urasaki, Junichi Kuratsu, Akira Takada, Tadashi Terasaki, Isao Fuwa Hisami Oosima, Shigeo Yamashiro, Makoto Yoshikawa Hiromasa Tsuiki, Kazunari Koga, Hiroshi Egami, Tadao Kawamura, Kunihiko Mitsuo, Takamitu Hikawa Masaki Morisige, Yuu Takeda, Yutaka Yamaguchi, Shiro Miyata Shunro Uchinokura, Tomokazu Goya, Hideo Takeshima, Kazutaka Yatsushiro, Hajime Ohta, Tatsui Nagadou, Kazuho Hirahara, Souichi Obara, Hiroshi Seto, Koiti Moroki, Kazunori Arita, Shogo Ishiuchi, Toshimitsu Uchihara, Susumu Mekaru, Tomoaki Nagamine, Naoki Tomiyama Jin Momoji, Kouzi Idomari Atusi Kimoto, Tsutomu Kadekaru, Hirosi Syamoto, Osamu Sasaki, Makoto Minagawa, Hideaki Takahashi, Kiyoshi Onda Hiroyuki Arai, Shigekazu Takeuchi, Hiroshi Abe, Osamu Fukuda, Mitsuo Kouno, Tetsuro Tamura, Yukio Horie Michiya Kubo, Hiroaki Hondo, Hisashi Takada, Toru Masuoka, Naoki Shirasaki, Hisashi Nitta, Makoto Kimura Yasuo Katsuki, Yutaka Hayashi Hisato Minamide, Shigeru Munemoto, Kiyonobu Ikeda, Mitsutoshi Nakada Yutaka Hayashi, Syuji Sato, Taketo Hatano, Osamu Yamamura, Masanori Kabuto, Takahiro Sakuma Jyunya Hayashi, Hiroyuki Kinouchi, Hidehito Koizumi, Syougo Imae, Manabu Fujita, Masakazu Suga, Shinji Iwata Kanehisa Kohno, Kiichiro Zenke, Mutsuo Fujisawa, Hikaru Mizobuchi, Satoru Hayashi, Masanori Morimoto, Tetsuya Ueba, Hiroyuki Nishimura, Naoki Ikawa, Yuzo Matsumoto, Seiji Kannuki, Masahiro Kagawa, Naoki Hayashi, Takashi Tamiya Atsushi Shindo, Kimihiro Yoshino, Tetsuya Masaoka, Ichiro Nakahara, Akira Nakamizo Satoshi Suzuki, Yuji Okamoto, Haruki Takahashi, Katsuyuki Hirakawa, Shinji Nagata, Akio Ookura, Hidenori Yoshida Yoshiro Kaneko, Hiroshi Nakane, Isao Inoue, Tsutomu Hitotsumatsu, Terukazu Kuramoto Kouichi Kuramoto, Yoshihisa Matumoto Hiromichi Ooishi, Tooru Inoue Masani Nonaka, Motohiro Morioka, Hiroshi Sugimori Shuji Sakata, Hiroshi Takashima, Shin-Ichiro Ishihara, Kenji Suzuyama, Masayuki Miyazono, Masafumi Morimoto Itaro Hattori, Satoshi Ozaki, Nobuo Hirota, Yasunori Takemoto Yasuhiko Mochimatsu, Makoto Takagi, Isao Yamamoto Kenji Nakayama, Yoshinori Uchida Hiroshi Tanaka, Katsumi Sakata, Kawahara Nobutaka, Motohiro Nomura, Hitoshi Ozawa, Kotaro Tsumura, Makoto Inaba Michiyuki Maruyama, Tatsuro Mori, Takahisa Mori, Masato Sugitani, Yuichiro Tanaka, Masaru Yamada, Mitsunori Matsumae, Keiichirou Onitsuka, Kosuke Miyahara Tatsuya Takahashi, Sumio Endou, Hidekazu Takahashi, Hiroyuki Kaidu, Akira Tsunoda Chikashi Maruki, Takamitsu Fujimaki, Hidetoshi Ooigawa, Masahiko Tanaka Masatsugu Uchida, Hiroshi Wanihuti Kouiti Katoh, Akio Hyodo, Ken Asakura, Shigeyoshi Nakajima, Takao Kanzawa, Hideyuki Kurihara, Sigehiro Ohmori, Mitsugi Yoshinao Hiroshi Kusunoki, Satoshi Magarisawa, Shinichi Okabe, Yuuji Kujiraoka, Shin Tsuruoka, Mikihiko Takeshita, Tetsuya Yamamoto Akira Matsumura, Kazuya Uemura, Hitoshi Tabata, Makoto Sonobe, Masashi Nakatsukasa Ryoji Yoshida, Norifumi Shimoeda, Hideo Kunimine, Masayuki Ishihara, Nozomu Murai, Nobukuni Murakami, Minoru Kidooka, Yoshihiro Iwamoto, Hiroshi Tenjin, Kouji Shiga Masahiko Takamasu, Nobuhito Mori, Shigeru Kose, Eiji Kohmura, Keigo Matsumoto, Takayuki Sakaki, Hiroji Miyake, Eiichiro Mabuchi, Masayuki Yokota, Hideyuki Ohnishi Yosihiro Kuga, Mitsuru Kimura, Osamu Narumi Masaaki Saiki, Norio Nakajima, Minoru Asahi, Junji Koyama, Shinya Noda, Junichi Iida, Toyohisa Fujita, Hiroyuki Nakase, Hidehiro Hirabayashi Toru Hoshida, Takayoshi Fujimoto, Naoyuki Nakao, Yoshiyuki Tanaka, Fuminori Ozaki, Yoshinari Nakamura, Kazuhito Miki, Takashi Watanabe, Seiko Hasegawa, Hiromu Konno, Atsuhito Takemura, Atsuya Okubo, Hitoshi Saito, Tatsuya Ishikawa Taizen Nakase, Hiroaki Shimizu Toshio Sasajima, Masayuki Sasou, Yoichi Watanabe, Taku Sato Kiyoshi Saito, Satoshi Taira Masahiro Satoh, Takayuki Koizumi, Yasuhiro Suzuki Shoji Mashiyama, Tomoyoshi Oikawa, Yukihiko Sonoda, Rei Kondo Shinjiro Saito, Atsuo Shinoda, Eiichiro Kamatsuka, Keiten So, Toshihiko Kinjo, Tooru Sasaki Kennji Itou, Hidenori Endo Hiroaki Shimizu, Hirosi Karibe, Kou Takahashi, Masayuki Nakajima, Kazuyoshi Watanabe, Motohiro Takayama, Taro Komuro, Hisao Hirai Fumio Suzuki, Hidenori Suzuki, Hiroto Murata, Fumitaka Miya, Kenji Kanamaru, Akira Tamura, Kiyoshi Harada, Seiji Fukazawa, Seiya Takehara, Yoshihiko Watanabe, Teiji Nakayama, Haruhiko Sato Hiroshi Nagura, Shinji Amano Chiharu Tanoi, Katsuhiro Kuroda, Satoru Morooka, Takafumi Wataya Masashi Kitagawa, Kazuo Koide, Tetsuya Tanigawara, Toru Iwama, Junki Ito, Shinji Noda, Kazuyuki Kouno, Kazuo Kitazawa, Yoshikazu Kusano Toshiki Takemae, Masanobu Hokama, Hiroki Sato Yoshihisa Nishiyama, Tatsuya Seguchi, Sumio Kobayashi Yoshihiko Inui, Youji Oohigashi, Shinsuke Muraoka, Masaki Miyatake, Kensuke Hayashida Nakagawa Shinichi, Atsushi Inoue, Keiichi Sakai, Shuhei Yamaguchi, Tatsuya Mizoue Fusao Ikawa, Gen Ishida Hideki Irie, Takato Kagawa, Yoichiro Namba, Hiroyuki Nakashima, Isao Date Koji Abe, Masaaki Uno, Masaki Chin Sen Yamagata, Hidemiti Sasayama Soitiro Takao, Hideyuki Yoshida Kouji Muneda, Akira Watanebe, Syouichi Katou, Yasuhiro Hamada, Takafumi Nishizaki, Katsuhiro Yamashita, Takaharu Nakamura Ryuji Nakamura, Shinichi Wakabayashi, Takahito Okazaki, Kaoru Kurisu, Masayasu Matsumoto, Atsushi Tominaga Katsuzo Kiya, Masaaki Shibukawa Syuichi Oki, Toshinori Nakahara, Shinji Okita, Tuyosi Torii, Minoru Nakagawa Kenjirou Fujiwara, Takashi Matsuoka Syuuhei Nishimura, Osamu Hamasaki Naoyuki Isobe, Junichiro Satomi Shinji Nagahiro, Masahito Agawa, Hirofumi Oka, Kunikazu Yoshimura, Tsutomu Kato, Nobuaki Kobayasi Satoshi Minoshima, Nobuhiro Mikuni, Rokuya Tanikawa, Jyunkou Sasaki, Yasunari Otawara, Teiji Tominaga, Tatsuya Sasaki, Sunao Takemura, Masahisa Kawakami, Satoshi Ihara, Yasushi Shibata, Takashi Saegusa, Toshihiko Iuchi, Chiaki Ito, Osamu Okuda, Kazunari Yoshida, Sadao Suga Masateru Katayama, Oikawa Akihiro, Naohisa Miura, Takahiro Ota, Toshihiro Kumabe, Sachio Suzuki, Takashi Kumagai, Keiichi Nishimaki, Kazuhiro Hongo, Hiroaki Shigeta, Kazuyoshi Hattori, Yoichi Uozumi, Norimoto Nakahara, Nobukazu Hashimoto, Shinichi Shirakami Shu Imai, Yoshinari Okumura, Ryo Tamaki Kazuhiro Yokoyama, Susumu Miyamoto, Kazuo Yamamoto, Tsugumichi Ichioka, Tsuyoshi Inoue, Manabu Kinoshita, Minoru Saitoh, Hideo Aihara, Hajimu Miyake, Kotaro Ogihara Tukasa Nishiura, Shigeki Nishino, Yasuyuki Miyoshi, Tadashi Arisawa, Shigeru Daido Shoji Tsuchimoto, Kimihisa Kinoshita, Kiyoshi Yuki Keisuke Migita, Keiichi Akatsuka, Hirosuke Fujisawa, Tadahisa Shono, Hitoshi Tsugu, Shuji Hayashi, Tatsuya Abe Toshio Matsushima, Susumu Nakashima, Takehisa Tuji, Akihiko Kaga, Reizou Kanemaru, Koji Takasaki, Junichi Imamura, Masahiro Noha, Saburo Watanabe, Nobuyuki Sakai, Yasuhisa Yoshida Hiroaki Minami, Tomoyoshi Okumura, Shinjitsu Nishimura, Shinichi Numazawa, Kiyoshi Kazekawa Masanori Tsutsumi, Kouzou Fukuyama, and Yasuhiro Fujimoto

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Databases, Factual, Traumatic brain injury, Nationwide survey, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Level of consciousness, Japan, Surveys and Questionnaires, Epidemiology, Brain Injuries, Traumatic, medicine, Humans, Hospital Mortality, Child, Aged, Retrospective Studies, Aged, 80 and over, Univariate analysis, business.industry, Neurological status, Glasgow Coma Scale, Age Factors, Infant, Newborn, Infant, Odds ratio, Middle Aged, medicine.disease, Patient Discharge, 030220 oncology & carcinogenesis, Child, Preschool, Emergency medicine, Surgery, Female, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

The epidemiology of patients with traumatic brain injury (TBI) has changed dramatically over recent decades as a result of rapid advances in aging societies. We assessed the influence of age on outcomes of patients with TBI and sought to identify prognostic factors for in-hospital mortality of TBI among elderly patients.Using a nationwide database, we analyzed data from 5651 patients with TBI. Univariate analysis was conducted to compare patient demographics, neurologic status on admission, radiologic findings, systemic complication rates, length of hospital stay, in-hospital mortality, and home discharge rates between elderly and nonelderly groups. Multivariable analysis was conducted to determine prognostic factors for in-hospital mortality among elderly patients.Overall in-hospital mortality was significantly higher in elderly patients (12.8% vs. 19.3%; P0.001). In-hospital mortality of elderly patients with mild TBI increased significantly at7 days after admission, whereas that of elderly patients with moderate or severe TBI was significantly higher immediately after admission. Age (odds ratio [OR], 1.62; P = 0.024), male sex (OR, 1.30; P = 0.004), Japan Coma Scale score on admission (OR, 5.95, P0.001), and incidence of acute subdural hematoma (OR, 1.89; P0.001) were associated with in-hospital mortality in elderly patients with TBI.Elderly patients with TBI showed significantly higher in-hospital mortality. Delayed increases in in-hospital mortality were observed among elderly patients with mild TBI. Level of consciousness on admission was the strongest predictor of in-hospital mortality among elderly patients.

Published
2019

4. A Rare Case of Neurofibromatosis Type 1 Associated with Vertebral Arteriovenous Fistula and Moyamoya Syndrome

Author

Toru Horikoshi, Hiroyuki Kinouchi, Kazuya Kanemaru, Hideyuki Yoshioka, Tsutomu Yagishita, Koji Hashimoto, Yoshihisa Nishiyama, and Katsuhiro Kuroda

Subjects
medicine.medical_specialty, business.industry, Arteriovenous fistula, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Rare case, Medicine, Neurology (clinical), Radiology, Neurofibromatosis, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery
Published
2017
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5. The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury)

Author

Yamagami, Keitaro, primary, Kurogi, Ryota, additional, Kurogi, Ai, additional, Nishimura, Kunihiro, additional, Onozuka, Daisuke, additional, Ren, Nice, additional, Kada, Akiko, additional, Nishimura, Ataru, additional, Arimura, Koichi, additional, Ido, Keisuke, additional, Mizoguchi, Masahiro, additional, Sakamoto, Tetsuya, additional, Kayama, Takamasa, additional, Suzuki, Michiyasu, additional, Arai, Hajime, additional, Hagihara, Akihito, additional, Iihara, Koji, additional, Takigami, Masayoshi, additional, Kamiyama, Kenji, additional, Houkin, Kiyohiro, additional, Nishi, Shougo, additional, Yoshimoto, Tetsuyuki, additional, Kaneko, Sadao, additional, Oka, Koji, additional, Ooyama, Hiroshi, additional, Kamada, Kyousuke, additional, Makino, Kenichi, additional, Tokumitsu, Naoki, additional, Sako, Kazuhiro, additional, Suzuki, Susumu, additional, Suzuki, Nozomi, additional, Izumi, Naoto, additional, Nitta, Kazumi, additional, Ootaki, Masahumi, additional, Isobe, Masanori, additional, Nishiya, Mikio, additional, Yamazaki, Takaaki, additional, Mabuchi, Syouji, additional, Ogasawara, Kuniaki, additional, Kubo, Naohiko, additional, Shimizu, Yukihiko, additional, Saito, Keiichi, additional, Yamanome, Tatumi, additional, Yoshino, Atsuo, additional, Fujitsuka, Mitsuyuki, additional, Takami, Masaaki, additional, Ohtaka, Hirotoshi, additional, Hirano, Teruyuki, additional, Shiokawa, Yosiaki, additional, Okada, Takaharu, additional, Suzuki, Ichiro, additional, Kohno, Michihiro, additional, Haraoka, Jou, additional, Arai, Yoshinori, additional, Kawamura, Noriyoshi, additional, Isoshima, Akira, additional, Yasue, Masaharu, additional, Takayoshi Kobayashi, Mitsuhiko Hokari, additional, Kawai, Kensuke, additional, Maehara, Taketoshi, additional, Noguchi, Makoto, additional, Hoshino, Haruhiko, additional, Hiyama, Hirofumi, additional, Yoshida, Kensaku, additional, Utsugi, Osamu, additional, Takeda, Yasuaki, additional, Tamaki, Kouichi, additional, Karasudani, Hirohide, additional, Urabe, Takao, additional, Kobayashi, Shiro, additional, Nakamura, Michio, additional, Koguchi, Yorio, additional, Ono, Junichi, additional, Suda, Sumio, additional, Hadeishi, Hiromu, additional, Fukutake, Toshio, additional, Wakui, Kenji, additional, Tanno, Hirokazu, additional, Ishige, Naoki, additional, Ohasi, Takashi, additional, Sakai, Hideki, additional, Nishimura, Yasuaki, additional, Watanabe, Takayuki, additional, Matsumoto, Takashi, additional, Koketsu, Naoki, additional, Hirose, Yuichi, additional, Doyu, Manabu, additional, Hasegawa, Toshinori, additional, Kuwayama, Naoto, additional, Terao, Shinichi, additional, Mizutani, Nobuhiko, additional, Suzaki, Noriyuki, additional, Okuda, Satoshi, additional, Yasui, Keizo, additional, Seki, Yukio, additional, Hasegawa, Yasuhiro, additional, Ikeda, Akira, additional, Takeuchi, Youtarou, additional, Ohara, Sigeki, additional, Araki, Yoshio, additional, Wakabayashi, Toshihiko, additional, Tanaka, Hisashi, additional, Yoshimoto, Junpei, additional, Sugiura, Makoto, additional, Koichiro, Ogura, additional, Kobayashi, Nozomu, additional, Yamada, Tomonori, additional, Kato, Amami, additional, Toshiho, Ohtsuki, additional, Wakayama, Akatsuki, additional, Takahashi, Jun, additional, Kataoka, Hiroharu, additional, Yoshimine, Toshiki, additional, Nakajima, Yoshikazu, additional, Gi, Hidehuku, additional, Uranishi, Ryunosuke, additional, Nakamura, Yusaku, additional, Yamanaka, Kazunori, additional, Ohmori, Kazumi, additional, Matsumoto, Hiroyuki, additional, Oiwa, Yoshitugu, additional, Uemura, Yosihiko, additional, Fujiwara, Hiroaki, additional, Iwai, Yoshiyasu, additional, Morikawa, Masashi, additional, Tane, Kazuyuki, additional, Hashikawa, Kazuo, additional, Fujinaka, Toshiyuki, additional, Yoneda, Shunichi, additional, Yamashita, Kohsuke, additional, Kitano, Masahiko, additional, Tominaga, Shinsuke, additional, Nakamura, Kazuhito, additional, Kono, Katsuhiko, additional, Ohata, Kenji, additional, Taniguchi, Hirokatsu, additional, Hazama, Takanori, additional, Kuroiwa, Toshihiko, additional, Tamura, Yoji, additional, Maeno, Kazusige, additional, Arai, Motohiro, additional, Iwase, Masaaki, additional, Hashimoto, Kenji, additional, Yamada, Keisuke, additional, Turuno, Takashi, additional, Ichinose, Tsutomu, additional, Kurokawa, Shinichiro, additional, Matsuyama, Takeshi, additional, Fujita, Toshiaki, additional, Yuguchi, Takamichi, additional, Teramoto, Yoshihumi, additional, Kakita, Hiroto, additional, Matsuo, Takayuki, additional, Izumo, Tsuyoshi, additional, Ryu, Nobutoshi, additional, Naoki Kitagawa, Wataru Haraguchi, additional, Kaminogo, Makio, additional, Sakamoto, Seisaburo, additional, Tokunaga, Yosiharu, additional, Urasaki, Ei-Ichirou, additional, Kuratsu, Junichi, additional, Takada, Akira, additional, Terasaki, Tadashi, additional, Hisami Oosima, Isao Fuwa, additional, Yamashiro, Shigeo, additional, Hiromasa Tsuiki, Makoto Yoshikawa, additional, Koga, Kazunari, additional, Egami, Hiroshi, additional, Kawamura, Tadao, additional, Mitsuo, Kunihiko, additional, Masaki Morisige, Takamitu Hikawa, additional, Takeda, Yuu, additional, Yamaguchi, Yutaka, additional, Shunro Uchinokura, Shiro Miyata, additional, Goya, Tomokazu, additional, Takeshima, Hideo, additional, Yatsushiro, Kazutaka, additional, Ohta, Hajime, additional, Nagadou, Tatsui, additional, Hirahara, Kazuho, additional, Obara, Souichi, additional, Seto, Hiroshi, additional, Moroki, Koiti, additional, Arita, Kazunori, additional, Ishiuchi, Shogo, additional, Uchihara, Toshimitsu, additional, Mekaru, Susumu, additional, Nagamine, Tomoaki, additional, Jin Momoji, Naoki Tomiyama, additional, Atusi Kimoto, Kouzi Idomari, additional, Kadekaru, Tsutomu, additional, Syamoto, Hirosi, additional, Sasaki, Osamu, additional, Minagawa, Makoto, additional, Takahashi, Hideaki, additional, Hiroyuki Arai, Kiyoshi Onda, additional, Takeuchi, Shigekazu, additional, Abe, Hiroshi, additional, Fukuda, Osamu, additional, Kouno, Mitsuo, additional, Tamura, Tetsuro, additional, Michiya Kubo, Yukio Horie, additional, Hondo, Hiroaki, additional, Takada, Hisashi, additional, Masuoka, Toru, additional, Shirasaki, Naoki, additional, Nitta, Hisashi, additional, Yasuo Katsuki, Makoto Kimura, additional, Hisato Minamide, Yutaka Hayashi, additional, Munemoto, Shigeru, additional, Ikeda, Kiyonobu, additional, Yutaka Hayashi, Mitsutoshi Nakada, additional, Sato, Syuji, additional, Hatano, Taketo, additional, Yamamura, Osamu, additional, Kabuto, Masanori, additional, Jyunya Hayashi, Takahiro Sakuma, additional, Kinouchi, Hiroyuki, additional, Koizumi, Hidehito, additional, Imae, Syougo, additional, Fujita, Manabu, additional, Suga, Masakazu, additional, Kanehisa Kohno, Shinji Iwata, additional, Zenke, Kiichiro, additional, Fujisawa, Mutsuo, additional, Mizobuchi, Hikaru, additional, Hayashi, Satoru, additional, Morimoto, Masanori, additional, Ueba, Tetsuya, additional, Nishimura, Hiroyuki, additional, Ikawa, Naoki, additional, Matsumoto, Yuzo, additional, Kannuki, Seiji, additional, Kagawa, Masahiro, additional, Hayashi, Naoki, additional, Atsushi Shindo, Takashi Tamiya, additional, Yoshino, Kimihiro, additional, Masaoka, Tetsuya, additional, Nakahara, Ichiro, additional, Satoshi Suzuki, Akira Nakamizo, additional, Okamoto, Yuji, additional, Takahashi, Haruki, additional, Hirakawa, Katsuyuki, additional, Nagata, Shinji, additional, Ookura, Akio, additional, Yoshiro Kaneko, Hidenori Yoshida, additional, Nakane, Hiroshi, additional, Inoue, Isao, additional, Hitotsumatsu, Tsutomu, additional, Kouichi Kuramoto, Terukazu Kuramoto, additional, Hiromichi Ooishi, Yoshihisa Matumoto, additional, Masani Nonaka, Tooru Inoue, additional, Morioka, Motohiro, additional, Shuji Sakata, Hiroshi Sugimori, additional, Takashima, Hiroshi, additional, Ishihara, Shin-Ichiro, additional, Suzuyama, Kenji, additional, Miyazono, Masayuki, additional, Itaro Hattori, Masafumi Morimoto, additional, Ozaki, Satoshi, additional, Hirota, Nobuo, additional, Yasuhiko Mochimatsu, Yasunori Takemoto, additional, Takagi, Makoto, additional, Kenji Nakayama, Isao Yamamoto, additional, Hiroshi Tanaka, Yoshinori Uchida, additional, Sakata, Katsumi, additional, Nobutaka, Kawahara, additional, Nomura, Motohiro, additional, Ozawa, Hitoshi, additional, Tsumura, Kotaro, additional, Michiyuki Maruyama, Makoto Inaba, additional, Mori, Tatsuro, additional, Mori, Takahisa, additional, Sugitani, Masato, additional, Tanaka, Yuichiro, additional, Yamada, Masaru, additional, Matsumae, Mitsunori, additional, Onitsuka, Keiichirou, additional, Tatsuya Takahashi, Kosuke Miyahara, additional, Endou, Sumio, additional, Takahashi, Hidekazu, additional, Kaidu, Hiroyuki, additional, Chikashi Maruki, Akira Tsunoda, additional, Fujimaki, Takamitsu, additional, Ooigawa, Hidetoshi, additional, Masatsugu Uchida, Masahiko Tanaka, additional, Kouiti Katoh, Hiroshi Wanihuti, additional, Hyodo, Akio, additional, Asakura, Ken, additional, Nakajima, Shigeyoshi, additional, Kanzawa, Takao, additional, Kurihara, Hideyuki, additional, Ohmori, Sigehiro, additional, Hiroshi Kusunoki, Mitsugi Yoshinao, additional, Magarisawa, Satoshi, additional, Okabe, Shinichi, additional, Kujiraoka, Yuuji, additional, Tsuruoka, Shin, additional, Takeshita, Mikihiko, additional, Akira Matsumura, Tetsuya Yamamoto, additional, Uemura, Kazuya, additional, Tabata, Hitoshi, additional, Sonobe, Makoto, additional, Ryoji Yoshida, Masashi Nakatsukasa, additional, Shimoeda, Norifumi, additional, Kunimine, Hideo, additional, Ishihara, Masayuki, additional, Murai, Nozomu, additional, Murakami, Nobukuni, additional, Kidooka, Minoru, additional, Iwamoto, Yoshihiro, additional, Tenjin, Hiroshi, additional, Masahiko Takamasu, Kouji Shiga, additional, Mori, Nobuhito, additional, Kose, Shigeru, additional, Kohmura, Eiji, additional, Matsumoto, Keigo, additional, Sakaki, Takayuki, additional, Miyake, Hiroji, additional, Mabuchi, Eiichiro, additional, Yokota, Masayuki, additional, Yosihiro Kuga, Hideyuki Ohnishi, additional, Kimura, Mitsuru, additional, Masaaki Saiki, Osamu Narumi, additional, Nakajima, Norio, additional, Asahi, Minoru, additional, Koyama, Junji, additional, Noda, Shinya, additional, Iida, Junichi, additional, Fujita, Toyohisa, additional, Nakase, Hiroyuki, additional, Toru Hoshida, Hidehiro Hirabayashi, additional, Fujimoto, Takayoshi, additional, Nakao, Naoyuki, additional, Tanaka, Yoshiyuki, additional, Ozaki, Fuminori, additional, Nakamura, Yoshinari, additional, Miki, Kazuhito, additional, Watanabe, Takashi, additional, Hasegawa, Seiko, additional, Konno, Hiromu, additional, Takemura, Atsuhito, additional, Okubo, Atsuya, additional, Saito, Hitoshi, additional, Taizen Nakase, Tatsuya Ishikawa, additional, Toshio Sasajima, Hiroaki Shimizu, additional, Sasou, Masayuki, additional, Watanabe, Yoichi, additional, Kiyoshi Saito, Taku Sato, additional, Masahiro Satoh, Satoshi Taira, additional, Koizumi, Takayuki, additional, Shoji Mashiyama, Yasuhiro Suzuki, additional, Oikawa, Tomoyoshi, additional, Sonoda, Yukihiko, additional, Shinjiro Saito, Rei Kondo, additional, Shinoda, Atsuo, additional, Kamatsuka, Eiichiro, additional, So, Keiten, additional, Kinjo, Toshihiko, additional, Kennji Itou, Tooru Sasaki, additional, Hiroaki Shimizu, Hidenori Endo, additional, Karibe, Hirosi, additional, Takahashi, Kou, additional, Nakajima, Masayuki, additional, Watanabe, Kazuyoshi, additional, Takayama, Motohiro, additional, Komuro, Taro, additional, Fumio Suzuki, Hisao Hirai, additional, Suzuki, Hidenori, additional, Murata, Hiroto, additional, Miya, Fumitaka, additional, Kanamaru, Kenji, additional, Tamura, Akira, additional, Harada, Kiyoshi, additional, Fukazawa, Seiji, additional, Takehara, Seiya, additional, Watanabe, Yoshihiko, additional, Nakayama, Teiji, additional, Hiroshi Nagura, Haruhiko Sato, additional, Chiharu Tanoi, Shinji Amano, additional, Kuroda, Katsuhiro, additional, Morooka, Satoru, additional, Masashi Kitagawa, Takafumi Wataya, additional, Koide, Kazuo, additional, Tanigawara, Tetsuya, additional, Iwama, Toru, additional, Ito, Junki, additional, Noda, Shinji, additional, Kouno, Kazuyuki, additional, Kitazawa, Kazuo, additional, Toshiki Takemae, Yoshikazu Kusano, additional, Hokama, Masanobu, additional, Yoshihisa Nishiyama, Hiroki Sato, additional, Seguchi, Tatsuya, additional, Yoshihiko Inui, Sumio Kobayashi, additional, Oohigashi, Youji, additional, Muraoka, Shinsuke, additional, Miyatake, Masaki, additional, Nakagawa Shinichi, Kensuke Hayashida, additional, Inoue, Atsushi, additional, Sakai, Keiichi, additional, Yamaguchi, Shuhei, additional, Fusao Ikawa, Tatsuya Mizoue, additional, Hideki Irie, Gen Ishida, additional, Kagawa, Takato, additional, Namba, Yoichiro, additional, Nakashima, Hiroyuki, additional, Koji Abe, Isao Date, additional, Uno, Masaaki, additional, Sen Yamagata, Masaki Chin, additional, Soitiro Takao, Hidemiti Sasayama, additional, Kouji Muneda, Hideyuki Yoshida, additional, Watanebe, Akira, additional, Katou, Syouichi, additional, Hamada, Yasuhiro, additional, Nishizaki, Takafumi, additional, Yamashita, Katsuhiro, additional, Ryuji Nakamura, Takaharu Nakamura, additional, Wakabayashi, Shinichi, additional, Okazaki, Takahito, additional, Kurisu, Kaoru, additional, Matsumoto, Masayasu, additional, Katsuzo Kiya, Atsushi Tominaga, additional, Syuichi Oki, Masaaki Shibukawa, additional, Nakahara, Toshinori, additional, Okita, Shinji, additional, Torii, Tuyosi, additional, Kenjirou Fujiwara, Minoru Nakagawa, additional, Syuuhei Nishimura, Takashi Matsuoka, additional, Naoyuki Isobe, Osamu Hamasaki, additional, Shinji Nagahiro, Junichiro Satomi, additional, Agawa, Masahito, additional, Oka, Hirofumi, additional, Yoshimura, Kunikazu, additional, Kato, Tsutomu, additional, Satoshi Minoshima, Nobuaki Kobayasi, additional, Mikuni, Nobuhiro, additional, Tanikawa, Rokuya, additional, Sasaki, Jyunkou, additional, Otawara, Yasunari, additional, Tominaga, Teiji, additional, Sasaki, Tatsuya, additional, Takemura, Sunao, additional, Kawakami, Masahisa, additional, Ihara, Satoshi, additional, Shibata, Yasushi, additional, Saegusa, Takashi, additional, Iuchi, Toshihiko, additional, Ito, Chiaki, additional, Okuda, Osamu, additional, Yoshida, Kazunari, additional, Masateru Katayama, Sadao Suga, additional, Akihiro, Oikawa, additional, Miura, Naohisa, additional, Ota, Takahiro, additional, Kumabe, Toshihiro, additional, Suzuki, Sachio, additional, Kumagai, Takashi, additional, Nishimaki, Keiichi, additional, Hongo, Kazuhiro, additional, Shigeta, Hiroaki, additional, Hattori, Kazuyoshi, additional, Uozumi, Yoichi, additional, Nakahara, Norimoto, additional, Hashimoto, Nobukazu, additional, Shu Imai, Shinichi Shirakami, additional, Okumura, Yoshinari, additional, Kazuhiro Yokoyama, Ryo Tamaki, additional, Miyamoto, Susumu, additional, Yamamoto, Kazuo, additional, Ichioka, Tsugumichi, additional, Inoue, Tsuyoshi, additional, Kinoshita, Manabu, additional, Saitoh, Minoru, additional, Aihara, Hideo, additional, Miyake, Hajimu, additional, Tukasa Nishiura, Kotaro Ogihara, additional, Nishino, Shigeki, additional, Miyoshi, Yasuyuki, additional, Arisawa, Tadashi, additional, Shoji Tsuchimoto, Shigeru Daido, additional, Kinoshita, Kimihisa, additional, Keisuke Migita, Kiyoshi Yuki, additional, Akatsuka, Keiichi, additional, Fujisawa, Hirosuke, additional, Shono, Tadahisa, additional, Tsugu, Hitoshi, additional, Hayashi, Shuji, additional, Toshio Matsushima, Tatsuya Abe, additional, Nakashima, Susumu, additional, Tuji, Takehisa, additional, Kaga, Akihiko, additional, Kanemaru, Reizou, additional, Takasaki, Koji, additional, Imamura, Junichi, additional, Noha, Masahiro, additional, Watanabe, Saburo, additional, Sakai, Nobuyuki, additional, Hiroaki Minami, Yasuhisa Yoshida, additional, Okumura, Tomoyoshi, additional, Nishimura, Shinjitsu, additional, Numazawa, Shinichi, additional, Masanori Tsutsumi, Kiyoshi Kazekawa, additional, Fukuyama, Kouzou, additional, and Fujimoto, Yasuhiro, additional

Published
2019
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6. Cerebral hemodynamic disturbance in dural arteriovenous fistula with retrograde leptomeningeal venous drainage: a prospective study using 123I-iodoamphetamine single photon emission computed tomography

Author

Yuichiro Fukumoto, Toru Horikoshi, Takashi Yagi, Hiroshi Onishi, Hiroyuki Kinouchi, Koji Hashimoto, Kazuya Kanemaru, Takuma Wakai, Hideyuki Yoshioka, Yoshihisa Nishiyama, and Takako Umeda

Subjects
Adult, Male, medicine.medical_specialty, Encephalopathy, Arteriovenous fistula, Infarction, Hyperemia, Single-photon emission computed tomography, Severity of Illness Index, Neurosurgical Procedures, Iodine Radioisotopes, Edema, medicine, Humans, Prospective Studies, Prospective cohort study, Aged, Retrospective Studies, Aged, 80 and over, Central Nervous System Vascular Malformations, Tomography, Emission-Computed, Single-Photon, Brain Diseases, medicine.diagnostic_test, business.industry, Endovascular Procedures, Hemodynamics, Reproducibility of Results, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Amphetamine, Cerebral blood flow, Regional Blood Flow, Cerebral hemodynamics, Cerebrovascular Circulation, Drainage, Female, Radiology, medicine.symptom, business
Abstract

OBJECT The severity of cerebral hemodynamic disturbance caused by retrograde leptomeningeal venous drainage (RLVD) of a dural arteriovenous fistula (dAVF) is related to neurological morbidity and unfavorable outcome. However, the cerebral hemodynamics of this disorder have not been elucidated well. The aim of this study was to assess the relationship between the cerebral venous congestive encephalopathy represented as a high-intensity area (HIA) on T2-weighted MR images and the cerebral hemodynamics examined by 123I-iodoamphetamine (IMP) single photon emission computed tomography (SPECT), as well as the predictive value of 123I-IMP SPECT for the development and reversibility of venous congestion encephalopathy. METHODS Based on the pre- and posttreatment T2 HIAs associated with venous congestion encephalopathy, patients were divided into 3 groups: a normal group, an edema group, and an infarction group. The regional cerebral blood flow (rCBF) at the region with RLVD was analyzed by 123I-IMP SPECT, and the results were compared among the groups. RESULTS There were 11, 6, and 3 patients in the normal, edema, and infarction groups, respectively. No patients in the normal group showed any symptoms related to venous congestion. In contrast, all patients in the edema and infarction groups developed neurological symptoms. The rCBF in the edema group was significantly lower than that in the normal group, and significantly higher than that in the infarction group. The cerebral vascular reactivity (CVR) of the infarction group was significantly lower than that of the normal and edema groups. After treatment, the neurological signs disappeared in the edema group, but only partial improvement was seen in the infarction group. The rCBF also significantly increased in the normal and edema groups, but not in the infarction group. CONCLUSIONS Quantitative rCBF measurement is useful for evaluating hemodynamic disturbance in dAVF with RLVD. The reduction of rCBF was strongly correlated with the severity of venous congestive encephalopathy, and loss of CVR is a reliable indicator of irreversible venous infarction caused by RLVD.

Published
2015
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7. Advantage of Microscope Integrated for Both Indocyanine Green and Fluorescein Videoangiography on Aneurysmal Surgery: Case Report

Author

Hiroyuki Kinouchi, Toru Horikoshi, Yoshihisa Nishiyama, Kazuya Kanemaru, Mitsuto Hanihara, Takashi Yagi, and Hideyuki Yoshioka

Subjects
Indocyanine Green, Microsurgery, medicine.medical_specialty, fluorescein, medicine.medical_treatment, videoangiography, Case Report, Video-Assisted Surgery, chemistry.chemical_compound, medicine, Humans, Fluorescein Angiography, Fluorescein, Catheter insertion, medicine.diagnostic_test, business.industry, Intracranial Aneurysm, Clipping (medicine), Middle Aged, Image Enhancement, Fluorescein angiography, eye diseases, Cerebral Angiography, Surgery, Radiographic Image Enhancement, Injections, Intra-Arterial, chemistry, Injections, Intravenous, clipping, Female, Neurology (clinical), business, Indocyanine green, Cerebral angiography
Abstract

Neck clipping of a large middle cerebral artery aneurysm was performed using a newly developed surgical microscope integrated with modules for both indocyanine green (ICG) and fluorescein videoangiography. During surgery, ICG and fluorescein videoangiography by intra-arterial or intravenous injection were safely carried out without interrupting the surgical procedure. Based on the findings obtained from the case, we evaluated the differences between the dyes and the injection routes. With intra-arterial injection, fluorescein offered sharper contrast images and was better at depicting fine arteries than ICG. Patchy staining of vessel walls was observed in intravenous fluorescein videoangiography, while it was not evident in ICG. Intra-arterial injection method had a great advantage in the rapid clearance of the dyes, which allowed us to perform repeated videoangiography within a short period, and was useful in detecting incomplete clipping in this case; however, catheter insertion requires additional work and carries a potential risk. Use of a microscope integrated for both ICG and fluorescein videoangiography would be another method for repeated evaluation. Namely, alternate use of the dyes enables us to perform videoangiography in a short time even via intravenous injection.

Published
2014
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8. Endoscopic Fluorescence Video Angiography in Aneurysm Surgery

Author

Kazuya Kanemaru, Koji Hashimoto, Takashi Yagi, Yoshihisa Nishiyama, Mitsuto Hanihara, Hiroyuki Kinouchi, Toru Horikoshi, Hideyuki Yoshioka, and Nobuo Senbokuya

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Angiography, Medicine, Aneurysm surgery, Radiology, business
Published
2014
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9. In-stent Thrombosis after Carotid Artery Stenting Despite Sufficient Antiplatelet Therapy in a Bladder Cancer Patient

Author

Koji Hashimoto, Hideyuki Yoshioka, Toru Horikoshi, Yoshihisa Nishiyama, Hiroyuki Kinouchi, Kaneo Satoh, Kazuya Kanemaru, Yukio Ozaki, and Mitsuto Hanihara

Subjects
Male, medicine.medical_specialty, Malignancy, Asymptomatic, Argatroban, medicine, Humans, Carotid Stenosis, cardiovascular diseases, Aged, Bladder cancer, business.industry, Carcinoma, Rehabilitation, Cancer, Thrombosis, medicine.disease, Surgery, Urinary Bladder Neoplasms, Concomitant, Stents, Neurology (clinical), Radiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Complication, Platelet Aggregation Inhibitors, medicine.drug
Abstract

In-stent thrombosis (IST) after carotid artery stenting (CAS) is a rare but potentially devastating complication. We present a case of early IST after CAS despite sufficient antiplatelet therapy in a patient with bladder cancer. A 77-year-old man under preventive triple antiplatelet therapy underwent CAS without any intra- or periprocedural complications. However, the patient developed a large asymptomatic IST 6 days after CAS. Anticoagulant therapy with argatroban was reintroduced to treat IST concomitant with antiplatelet agents. Subsequently, the IST shrank and disappeared without any thrombotic symptoms. Malignancy is regarded as an acquired thrombophilic condition associated with a significant risk of thrombosis. In the field of coronary stents, cancer is associated with a significant increasing risk of IST. The cause of IST in our case was possibly related in hypercoagulable state because of the patient's cancer. Attention for IST should be paid in CAS cases with these risk factors, and repeated examination is recommended.

Published
2013
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11. Endoscopic indocyanine green video angiography in aneurysm surgery: an innovative method for intraoperative assessment of blood flow in vasculature hidden from microscopic view

Author

Yoshihisa Nishiyama, Nobuo Senbokuya, Tatsuya Kato, Toru Horikoshi, Hiroyuki Kinouchi, Hideyuki Yoshioka, and Kazuya Kanemaru

Subjects
Indocyanine Green, Microsurgery, medicine.medical_specialty, Endoscope, Video Recording, chemistry.chemical_compound, Imaging, Three-Dimensional, Aneurysm, medicine.artery, Occlusion, Image Processing, Computer-Assisted, medicine, Humans, cardiovascular diseases, Coloring Agents, Intraoperative Complications, Aged, medicine.diagnostic_test, business.industry, Endoscopy, Intracranial Aneurysm, General Medicine, Blood flow, Cerebral Arteries, Middle Aged, Surgical Instruments, medicine.disease, Cerebral Angiography, chemistry, Perforating arteries, Regional Blood Flow, Angiography, cardiovascular system, Female, Radiology, business, Indocyanine green, Cerebral angiography
Abstract

Recently, intraoperative fluorescence video angiography using indocyanine green (ICG) has been widely used in aneurysm surgery. This is a simple and useful method to confirm complete occlusion of the aneurysm lumen and preservation of blood flow in the arteries around the aneurysm. However, the observation field of ICG video angiography is limited under a microscope, making it difficult to confirm the flow in the arteries behind the parent arteries or aneurysm. The authors developed a new technique of intraoperative endoscopic ICG video angiography to assess the blood flow in perforating arteries hidden by the parent arteries or aneurysm. The endoscope emits excitation light with a wavelength of approximately 800 nm, and video images were obtained through a cut filter. The authors used this ICG fluorescence endoscope in treating 3 patients with unruptured cerebral aneurysms. During clip placement, the endoscope was inserted to confirm aneurysm occlusion. Then, ICG was intravenously administered, and the fluorescence in the vessels was observed via the endoscope as well as under the microscope. The blood flow in the perforating arteries was clearly identified, and no procedural complication occurred. The authors conclude that the technique is very useful and facilitates intraoperative real-time assessment of the patency of perforating arteries behind parent arteries or aneurysms.

Published
2012
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12. Direct Clipping of a Thrombosed Giant Cerebral Aneurysm After Thrombectomy Without Bleeding to Minimize the Temporary Occlusion Time -Technical Case Report

Author

Kazuya Kanemaru, Masao Sugita, Toru Horikoshi, Hideyuki Yoshioka, Yoshihisa Nishiyama, and Hiroyuki Kinouchi

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Lumen (anatomy), Magnetic resonance imaging, Clipping (medicine), medicine.disease, Surgery, Aneurysm, Edema, cardiovascular system, medicine, cardiovascular diseases, Neurology (clinical), Radiology, Thrombus, medicine.symptom, Evoked potential, business, Craniotomy
Abstract

A 75-year-old man was referred to our hospital with a thrombosed giant middle cerebral artery aneurysm manifesting as progressive memory disturbance and disorientation. Magnetic resonance imaging and conventional angiography revealed a partially thrombosed giant aneurysm of the left middle cerebral artery bifurcation and edema of the adjacent brain which had enlarged compared to 3 months before. Surgery was performed through a left frontotemporal craniotomy. After exposure of the aneurysm neck, we tried to apply a clip, which slipped due to the intraaneurysmal thrombus. Intraoperative motor evoked potential monitoring showed decreased amplitude. Therefore, the aneurysm dome was incised and the intraaneurysmal thrombus near the neck was shaved with the ultrasonic aspirator, followed by neck clipping of the aneurysm. The residual thrombus was safely removed. Transient right hemiparesis was observed after surgery, but his memory disturbance gradually improved. Giant thrombosed aneurysm can be treated by reduction of the thrombus from the far side to the lumen to reduce the duration of parent artery occlusion required for clipping.

Published
2009
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13. Intracranial Pial Arteriovenous Fistula Caused by Dural Tenting: Case Report

Author

Hideyuki Yoshioka, Toru Horikoshi, Yoshihisa Nishiyama, Mitsuto Hanihara, Hiroyuki Kniouchi, and Kazuya Kanemaru

Subjects
Reoperation, medicine.medical_specialty, Fistula, Sylvian vein, medicine.medical_treatment, Video Recording, Arteriovenous fistula, Case Report, dural tenting, surgical complication, Postoperative Complications, Aneurysm, medicine.artery, medicine, Humans, Fluorescein Angiography, Central Nervous System Vascular Malformations, medicine.diagnostic_test, business.industry, Intracranial Aneurysm, Clipping (medicine), Middle Aged, medicine.disease, Cerebral Veins, pial arteriovenous fistula, Cerebral Angiography, nervous system diseases, Surgery, body regions, cerebral aneurysm, Angiography, Middle cerebral artery, cardiovascular system, Pia Mater, Female, Dura Mater, Neurology (clinical), Radiology, business, Craniotomy, circulatory and respiratory physiology, Cerebral angiography
Abstract

We describe a rare case where a patient developed intracranial pial arteriovenous (AV) fistula due to dural tenting. The patient was a 63-year-old woman who had undergone neck clipping for an unruptured middle cerebral artery (MCA) aneurysm. The surgery was performed without any problems and her postoperative course was uneventful. Two weeks after cerebral angiography operation revealed a pial AV fistula fed by the right MCA and drained into the vein of Trolard through the Sylvian vein which had not existed before surgery. Being diagnosed as de novo pial AV fistula, surgical repair was performed. The AV fistula was located just beneath the dural tenting. The fistulous point was confirmed with fluorescein video angiography and obliterated using a clip. Although rare, we should pay attention to the AV fistula due to dural tenting as the complications of cranial surgery.

Published
2014
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14. A rare case of focal multiple medullary venous malformations with ipsilateral cerebral surface varix

Author

Meguru Watanabe, Hiroyuki Kinouchi, Keiichi Ishigame, Yoshihisa Nishiyama, and Tsutomu Araki

Subjects
Male, medicine.medical_specialty, Medullary cavity, Adolescent, Contrast Media, Asymptomatic, Brain ct, White matter, Varicose Veins, Rare Diseases, Rare case, medicine, Craniocerebral Trauma, Humans, Radiology, Nuclear Medicine and imaging, Vein, Central Nervous System Vascular Malformations, Incidental Findings, Varix, business.industry, Rare entity, Cerebral Veins, medicine.anatomical_structure, Athletic Injuries, Radiology, medicine.symptom, business, Tomography, X-Ray Computed, Magnetic Resonance Angiography
Abstract

We report here a rare case of focal multiple venous malformations (VMs) in the white matter, via a draining vein arising from each VM, connecting with an ipsilateral cerebral surface venous varix. The male teen was asymptomatic neurologically. A diagnostic process using of MRI/MRDSA in this extremely rare entity is important as the more incidental discovery is expected with increasing opportunities of performing brain CT/MRI for various indications.

Published
2014

15. Anchor coil technique for arteriovenous fistula embolization. A technical note

Author

Masayuki Ezura, Yoshihisa Nishiyama, Hiroyuki Kinouchi, Toru Horikoshi, Takashi Yagi, Yuichiro Fukumoto, Hideyuki Yoshioka, and Kazuya Kanemaru

Subjects
Intracranial Arteriovenous Malformations, medicine.medical_specialty, Varix, business.industry, medicine.medical_treatment, Fistula, Infant, Newborn, Arteriovenous fistula, Equipment Design, Original Articles, medicine.disease, Embolization, Therapeutic, Shunt (medical), Shunting, Radiography, Treatment Outcome, Electromagnetic coil, Suture Anchors, medicine, Humans, Female, Radiology, Embolization, business
Abstract

We describe a case of arteriovenous fistula (AVF) successfully treated by coil embolization with an anchor coil inserted in the varix to facilitate dense packing at the shunting site. AVF of the left anterior choroidal artery (AChoA) draining into the ipsilateral basal vein of Rosenthal was incidentally found in a newborn female. A single detachable coil was inserted as an anchor into the varix adjacent to the shunt, and the microcatheter was pulled back to the shunting point. Three more detachable coils were delivered at the shunting point without migration under the support of the anchor coil, and the AVF was successfully obliterated with preservation of AChoA blood flow. The anchor coil technique can reduce the risk of coil migration and the number of coils required.

Published
2013

16. Intra-arterial injection fluorescein videoangiography in aneurysm surgery

Author

Hiroyuki Kinouchi, Masakazu Ogiwara, Hideyuki Yoshioka, Toru Horikoshi, Yoshihisa Nishiyama, Kazuya Kanemaru, and Katsuhiro Kuroda

Subjects
medicine.medical_treatment, Video Recording, chemistry.chemical_compound, Aneurysm, Occlusion, Medicine, Humans, Fluorescein, Fluorescein Angiography, Fluorescent Dyes, medicine.diagnostic_test, business.industry, Intracranial Aneurysm, Clipping (medicine), Blood flow, Digital subtraction angiography, medicine.disease, Cerebral Angiography, Catheter, medicine.anatomical_structure, chemistry, Injections, Intra-Arterial, Surgery, Neurology (clinical), business, Nuclear medicine, Artery
Abstract

Background To visualize blood flow in the arteries and aneurysm during surgery, intravenous fluorescence videoangiography has been used. However, the image contrast with this procedure is diminished by repeated study because the dye remains for about 10 minutes after injection. Objective To determine the optimal dye concentration and to clarify the usefulness of fluorescein videoangiography by intra-arterial dye injection. Methods In the pilot study, fluorescein sodium dissolved at various concentrations was illuminated with excitation light, and fluorescence was detected by cameras. The fluorescence of 0.001% fluorescein sodium solution mixed with plasma at various concentrations was then examined. In 13 aneurysm patients, dye solution was administered through the catheter for intraoperative digital subtraction angiography. The intravenous injection method was also performed, and the findings were compared. Results Dye was clinically used at a concentration of 0.005% to 0.1% on the basis of the results of the pilot study. Fluorescence emission from the vessels and aneurysms was clearly observed by both methods; however, arterial injection provided brighter emission, resulting in clearer demonstration of the bloodstream than venous injection. Dye clearance was also quicker, which allowed repeat injections without delay. Dye filling in the aneurysm indicating incomplete occlusion was detected in 2 cases, and occlusion of the perforating artery was observed in 2 cases. Conclusion Intra-arterial fluorescein videoangiography provides brighter and clearer imaging of blood flow with a smaller dose of dye than intravenous videoangiography. It can be repeated within a short time and is useful for detecting incomplete clipping or unexpected obstruction of arteries.

Published
2012

17. Effects of cilostazol on cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a multicenter prospective, randomized, open-label blinded end point trial

Author

Shinichi Yagi, Katsuhiro Kuroda, Nobuo Senbokuya, Kazuya Kanemaru, Mikito Uchida, Yasuhiro Ohashi, Yoshihisa Nishiyama, Hidehito Koizumi, Toru Horikoshi, Nobuyasu Takeuchi, Akira Fukamachi, Isao Fukasawa, Hideyuki Yoshioka, Tsuneo Shimizu, Teruo Takahashi, Hiroyuki Kinouchi, Chikashi Kobayashi, Koro Furuya, and Shin Nakano

Subjects
Male, Subarachnoid hemorrhage, Randomization, Vasodilator Agents, Population, Tetrazoles, Phosphodiesterase 3 Inhibitors, law.invention, symbols.namesake, Cerebral vasospasm, Randomized controlled trial, law, Modified Rankin Scale, Medicine, Humans, Vasospasm, Intracranial, cardiovascular diseases, Prospective Studies, education, Fisher's exact test, Aged, education.field_of_study, business.industry, Middle Aged, Subarachnoid Hemorrhage, medicine.disease, nervous system diseases, Cilostazol, Treatment Outcome, Anesthesia, symbols, Female, business, medicine.drug
Abstract

Object Cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) is a major cause of subsequent morbidity and mortality. Cilostazol, a selective inhibitor of phosphodiesterase 3, may attenuate cerebral vasospasm because of its antiplatelet and vasodilatory effects. A multicenter prospective randomized trial was conducted to investigate the effect of cilostazol on cerebral vasospasm. Methods Patients admitted with SAH caused by a ruptured anterior circulation aneurysm who were in Hunt and Kosnik Grades I to IV and were treated by clipping within 72 hours of SAH onset were enrolled at 7 neurosurgical sites in Japan. These patients were assigned to one of 2 groups: the usual therapy group (control group) or the add-on 100 mg cilostazol twice daily group (cilostazol group). The group assignments were done by a computer-generated randomization sequence. The primary study end point was the onset of symptomatic vasospasm. Secondary end points were the onset of angiographic vasospasm and new cerebral infarctions related to cerebral vasospasm, clinical outcome as assessed by the modified Rankin scale, and length of hospitalization. All end points were assessed for the intention-to-treat population. Results Between November 2009 and December 2010, 114 patients with SAH were treated by clipping within 72 hours from the onset of SAH and were screened. Five patients were excluded because no consent was given. Thus, 109 patients were randomly assigned to the cilostazol group (n = 54) or the control group (n = 55). Symptomatic vasospasm occurred in 13% (n = 7) of the cilostazol group and in 40% (n = 22) of the control group (p = 0.0021, Fisher exact test). The incidence of angiographic vasospasm was significantly lower in the cilostazol group than in the control group (50% vs 77%; p = 0.0055, Fisher exact test). Multiple logistic analyses demonstrated that nonuse of cilostazol is an independent factor for symptomatic and angiographic vasospasm. The incidence of new cerebral infarctions was also significantly lower in the cilostazol group than in the control group (11% vs 29%; p = 0.0304, Fisher exact test). Clinical outcomes at 1, 3, and 6 months after SAH in the cilostazol group were better than those in the control group, although a significant difference was not shown. There was also no significant difference in the length of hospitalization between the groups. No severe adverse event occurred during the study period. Conclusions Oral administration of cilostazol is effective in preventing cerebral vasospasm with a low risk of severe adverse events. Clinical trial registration no. UMIN000004347, University Hospital Medical Information Network Clinical Trials Registry.

Published
2012

19. MR digital subtraction angiography for the assessment of cranial arteriovenous malformations and fistulas

Author

Takeharu Yoshikawa, Hiroshi Kumagai, Masaaki Hori, Yoshihisa Nishiyama, Hideaki Nukui, Shigeki Aoki, Tsutomu Araki, and Atsushi Nanbu

Subjects
Adult, Intracranial Arteriovenous Malformations, Male, medicine.medical_specialty, Arterial disease, Image subtraction, Magnetic resonance angiography, Radiologic sign, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Aged, medicine.diagnostic_test, business.industry, Angiography, Digital Subtraction, Arteriovenous malformation, General Medicine, Digital subtraction angiography, Semiology, medicine.disease, Angiography, Arteriovenous Fistula, Female, Radiology, business, Magnetic Resonance Angiography
Published
2000

21. Effects of cilostazol on cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a multicenter prospective, randomized, open-label blinded end point trial.

Author

NOBUO SENBOKUYA, HIROYUKI KINOUCHI, KAZUYA KANEMARU, YASUHIRO OHASHI, AKIRA FUKAMACHI, SHINICHI YAGI, TSUNEO SHIMIZU, KORO FURUYA, MIKITO UCHIDA, NOBUYASU TAKEUCHI, SHIN NAKANO, HIDEHITO KOIZUMI, CHIKASHI KOBAYASHI, ISAO FUKASAWA, TERUO TAKAHASHI, KATSUHIRO KURODA, YOSHIHISA NISHIYAMA, HIDEYUKI YOSHOKA, and TORU HORIKOSHI

Published
2013
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