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1. Unusual Skin Reactions after Mosquito Bites and Epstein-Barr Virus Reactivation in a Patient with Mantle Cell Lymphoma

Author

Shigeharu Takai, Kazue Yamabe, Yoshihiro Takishita, Hiroko Ohmori, Shingo Wakatsuki, Masahito Chohraku, Shinsaku Ohtsuka, Toshio Shigekiyo, and Masanori Takahashi

Subjects
Male, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Lymphocytosis, Lymphoma, Mantle-Cell, medicine.disease_cause, Virus, immune system diseases, hemic and lymphatic diseases, Internal Medicine, Animals, Humans, Medicine, Lymphatic Diseases, Epstein–Barr virus infection, Skin, business.industry, Insect Bites and Stings, General Medicine, Middle Aged, medicine.disease, Virology, Epstein–Barr virus, Lymphoma, Culicidae, Immunology, Mantle cell lymphoma, Lymph Nodes, CD5, medicine.symptom, business, Generalized lymphadenopathy
Abstract

We detected Epstein-Barr virus (EBV) reactivation in a patient with mantle cell lymphoma (MCL). The patient, a 53-year-old Japanese man, had been referred to our hospital because of generalized lymphadenopathy, hepatosplenomegaly and lymphocytosis and gave a history of intense skin reactions to mosquito bites. The biopsied lymph node contained a monotonous proliferation of medium-sized lymphocytes with scant cytoplasm and slightly irregular nuclei that were CD5+, CD20+ and CD23-. Antibody titers of IgG against EBV viral capsid antigen and early antigen were increased, and EBV was detected in the lymphoma cells. This case may suggest a relationship between EBV and MCL.

Published
2004
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2. Arterial administration therapy with SMANCS/Lipiodol in a hemodialysis patient associated with hepatoma

Author

Hirohumi Izaki, Yoshihiro Takishita, Haruo Sumitani, Kohji Mizuta, Yorikazu Kagawa, Shuzoh Yamamoto, and Naohiko Hayashi

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Anesthesia, medicine, Lipiodol, Hemodialysis, Radiology, business, medicine.drug
Abstract

症例は71歳男性. 68歳の時腎機能低下を指摘され, 平成8年1月 (71歳時) より嘔気, 食欲不振が出現, 近医で末期腎不全を指摘され透析導入の目的で当院に紹介され入院した. 入院中に施行した腹部超音波で肝S8に肝癌を疑わせる腫瘤を認めたため, 腹部CT, 肝動脈造影を施行し肝癌と診断した. Zinostatin stimalamer (SMANCS) を, 初回は常用量の2/3に相当する4mgをlipiodolに溶解して選択的に肝動脈より注入した. 注入後, 白血球減少, 血小板減少, 肝機能および腎機能の増悪等の副作用は認めなかった. 9か月後, 腫瘍の増大を見たため, 再度SMANCS 6mgを含むSMANCS/Lipiodolとともに, ゼラチンスポンジゲルによる塞栓術を併用した (SMANCS/TAE). 特記すべき副作用もなく, 13か月後の現在良好に経過している. 今回の経験より, 透析患者にも常用量のSMANCSを用いた動注療法の可能であることが示唆された.

Published
1998
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3. Successful delivery in a patient with thrombotic thronbocytopenic purpura after plasma exchange

Author

Shin-ichi Hamada, Kazuhiko Higuchi, Hiroko Takahashi, Yoshihiro Takishita, and Hisayuki Kohno

Subjects
medicine.medical_specialty, Pregnancy, Purpura, business.industry, Internal medicine, Thrombotic thrombocytopenic purpura, medicine, medicine.symptom, medicine.disease, business, Gastroenterology
Abstract

血栓性血小板減少性紫斑病 (TTP), 特に妊娠に伴ったTTPの予後は非常に悪いことが知られている. しかし近年, 血液浄化法なかでもplasma exchange (PE) によりTTPの予後は著しく改善されている. しかし, まだTTP患者での出産成功例はごくわずかである. 今回, 我々はPEを行うことにより無事出産し得た1例を経験したので報告した.症例は31歳, 1986年, 25歳の時初回妊娠22週で胎児死亡を機にTTPを発症. 人工流産, PEおよび摘脾にて軽快していた. その後しばしば血小板減少をきたすことがあったが新鮮凍結血漿 (FFP) の輸注で改善し, さらにその後は血小板数は安定し, しばらく来院していなかった. 1991年, 30歳, 来院時に妊娠6週で本人の強い希望もあり妊娠を継続. 1992年, 妊娠35週で血小板減少をきたし緊急入院となる. 入院時, 血小板数3.2万, Hb 10.4g/dl, LDH 2,330IU/l. FFPおよび新鮮血輸血にも拘わらず血小板数の増加がなく, Hb 8.6g/dlと貧血も増強のため, 血小板輸血とともにPEを施行した後, 帝王切開を行った. PEはFFP 40単位 (約3,200ml) を用い, 抗凝固剤にメシル酸ナファモスタットを使用, 血液透析も併用, さらに翌日および翌々日と合計3回行った. その結果, 血小板数は速やかに増加し, また新生児も健康で, 母子ともに順調に経過している.今回の症例の経験からもPEを用いることにより, TTP患者においても無事出産し得ることが示された.

Published
1994
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4. Comparison of Cisplatin plus Vindesine with Cisplatin plus Mitomycin C for Treatment of Advanced Non-Small-Cell Lung Cancer

Author

Masaki Kobayashi, Saburo Sone, Yoshihiro Takishita, Takaki Hashimoto, Hiroyasu Bando, Haruo Sasaki, Yuhji Higuchi, Takeshi Ogura, Hiroyuki Doi, Tadashi Nakayama, Ichiro Kawase, Eiji Shimizu, and Kouichi Kimura

Subjects
inorganic chemicals, Cisplatin, Cancer Research, medicine.medical_specialty, Chemotherapy, Leukopenia, business.industry, medicine.medical_treatment, Mitomycin C, Respiratory disease, General Medicine, medicine.disease, Gastroenterology, female genital diseases and pregnancy complications, Surgery, Oncology, Internal medicine, medicine, Adenocarcinoma, Vindesine, medicine.symptom, Lung cancer, business, neoplasms, medicine.drug
Abstract

Seventy-six patients with advanced non-small-cell lung cancer were randomly allocated to two groups and treated with cisplatin (CDDP; 80 mg/m2 on day 1) plus either vindesine (VDS; 3 mg/m2 on days 1 and 8) or mitomycin C (MMC; 8 mg/m2 on days 1 and 8) every 3-4 weeks. The objective response rates were 26% (10/38) for CDDP plus VDS and 32% (11/34) for CDDP plus MMC; the corresponding response rates in patients with adenocarcinoma were 7% (1/14) and 43% (6/14), respectively. The median survival times ofpatients treated with CDDP plus VDS and CDDP plus MMC were 33 and 30 weeks, respectively, the difference in survival times in the two groups not being significant. There was no significant difference in toxic effects in the two groups except that alopecia and leukopenia were more frequent in patients treated with CDDP plus VDS.

Published
1993
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5. Alternating Chemotherapy with Cyclophosphamide/Adriamycin/Vincristine (CAV) and Cisplatin/Etoposide (PVP) agaist Small Cell Lung Cancer

Author

Hiroyuki Doi, Saburo Sone, Hiroyasu Bando, Takeshi Ogura, Yoshihiro Takishita, Masaki Kobayashi, Tadashi Nakayama, and Eiji Shimizu

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Vincristine, Cyclophosphamide, business.industry, Combination chemotherapy, General Medicine, medicine.disease, Chemotherapy regimen, Gastroenterology, Regimen, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, Doxorubicin, Lung cancer, business, Etoposide, medicine.drug
Abstract

Seventy-four confirmed small cell lung cancer (SCLC) patients received alternating combination chemotherapy with CAV and PVP. The CAV comprised of cyclophosphamide 800 mg/m2 on day 1, adriamycin 50 mg/m2 on day 1 and vincristine 1.4 mg/m2 on day 1, administered every 3-4 weeks. The PVP comprised cisplatin 80 mg/m2 on day 1 and etoposide 75 mg/m2 on day 1-5 administered every 3-4 weeks. Of these 74 patients, 63 (85.1%) achieved complete or partial responses with 16 (21.6%) obtaining a complete response. The median survival time was 13.2 months: 10.4 months in patients with extensive disease (ED), 16.3 months in those with limited disease (LD). A three-year disease-free period was achieved in eight patients (11.2%: 4.8% with ED, 16.8% with LD). The median duration of response was 28.3 weeks: 20.1 weeks with ED and 44.0 weeks with LD. The most commonly encountered side effects were nausea, vomiting, alopecia and myelosuppression but all were tolerable. We consider CAV-PVP to be an effective combination regimen for treating SCLC.

Published
1991
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6. Plasma exchange in a patient with postpartum HELLP syndrome

Author

Kazuhiko Higuchi, Osamu Naka, Hiroko Takahashi, Takao Tamura, Yoshihiro Takishita, and Shin-ichi Hamada

Subjects
Adult, medicine.medical_specialty, HELLP Syndrome, Anemia, HELLP syndrome, Erythrocytes, Abnormal, Liver Function Tests, Pregnancy, medicine, Humans, Proteinuria, medicine.diagnostic_test, Plasma Exchange, business.industry, Obstetrics, Postpartum Period, Pregnancy Outcome, Obstetrics and Gynecology, Microangiopathic hemolytic anemia, medicine.disease, Thrombocytopenia, Female, medicine.symptom, Liver function tests, business, Postpartum period
Abstract

The case of a patient with HELLP syndrome, who was unresponsive to supportive management but successfully treated with plasma exchange, is presented. The significance of plasma exchange in the treatment of HELLP syndrome is discussed.

Published
1996

7. Intravascular bronchioloalveolar tumor with skin metastases

Author

Hiroyasu Bando, Hiroaki Yanagawa, Yoshihiro Hashimoto, Takashi Nagano, and Yoshihiro Takishita

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, Pathology, medicine.medical_specialty, Younger age, Lung Neoplasms, Skin Neoplasms, Critical Care and Intensive Care Medicine, Metastasis, medicine, Humans, Skin metastasis, Lung, Skin, business.industry, Respiratory disease, Histology, medicine.disease, Primary tumor, medicine.anatomical_structure, Neoplasms, Vascular Tissue, Cardiology and Cardiovascular Medicine, business, Complication
Abstract

Intravascular bronchioloalveolar tumor (IVBAT) is a rare pulmonary tumor that occurs in the younger age groups. In the present article, we describe a patient who manifested systemic growth after the resection of the primary tumor. Skin metastasis, which has never been reported, is histologically examined.

Published
1994

8. [A comparative study between cefpirome (CPR) and ceftazidime (CAZ) in respiratory tract infections]

Author

Rinzo SOEJIMA, Masaru SUMI, Jiro HINO, Niro OKIMOTO, Yoshikazu KAWAKAMI, Etsuro YAMAGUCHI, Tsugio TERAI, Takashi YOSHIKAWA, Kazuo TAKAOKA, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Hidetoshi SHIBAKI, Koji TANEICHI, Tsuyoshi KIKUIRI, Masahide SHINOHARA, Akira MIWA, Choei ITO, Mitsuo SATO, Akira SUZUKI, Yasuhito HONDA, Kyuichiro SEKINE, Yomei HIRAGA, Mitsuhide OMICHI, Shinya YASUDA, Tetsuji KOROKU, Susumu ITO, Shoji KASAGI, Sokichi ONODERA, Yoshinobu OSAKI, Hiroyuki MATSUMOTO, Takafumi OTA, Eiichi SAKAI, Tetsuo SHIMIZU, Nobuhiro SASAKI, Toshiaki FUJIKANE, Satoshi FUJIUCHI, Toshiaki SHISHIDO, Kazuo TAKEBE, Atsuko YANADA, Mitsuo MASUDA, Seiichi MURAKAMI, Kenichi IMAMURA, Toyokazu TAMURA, Katsumi ENDO, Hideya MURABAYASHI, Shigeru OCHIAI, Hidekazu SAWADA, Michitaka SHIMURA, Masashi TAMURA, Kazuki KONISHI, Taiji YOSHIDA, Morio SUDO, Takeshi BANDO, Nobuhisa SATO, Masayuki OURA, Tetsuro UNOURA, Takashi MOURI, Tamotsu TAKISHIMA, Yasuo TANNO, Kunio KUDO, Munehiko ISHII, Masaharu SUGIYAMA, Masakichi MOTOMIYA, Akira WATANABE, Kosaku NAGAI, Kazuo SATO, Kiyoshi KONNO, Teruo HASUIKE, Kuniharu SHIDA, Satoshi SHINDO, Izumi HAYASHI, Jingoro SHIMADA, Masaki YOSHIDA, Atsushi SAITO, Koya SHIBA, Masanobu KAJI, Seiji HORI, Osamu SAKAI, Hideo MIYASHITA, Yasuo ONO, Masumi BABA, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Hiroshi MIURA, Takashi INOUE, Kaoru SHIMADA, Mieko GOTO, Hajime GOTO, Yasuyuki SANO, Yasufumi MIYAMOTO, Yasuo ARAI, Kanzaburo MATSUMURA, Yoshitaka NAKAMORI, Koji NARUI, Masayuki NOGUCHI, Tatsuo NAKATANI, Koichiro NAKATA, Iwao SAKURAI, Takeo IMAI, Fumio MATSUMOTO, Shigeki ODAGIRI, Masanori MATSUMURA, Kaneo SUZUKI, Kou MUROHASHI, Hiroshi TAKAHASHI, Kenichi TAKAHASHI, Teruaki YOSHIOKA, Izumi KOYAMA, Takashi OGURA, Masaaki ARAKAWA, Koichi WADA, Takashi KAWASHIMA, Masanaga TAKATO, Hidenori KUMANO, Nobuki AOKI, Tatsuo SATAKE, Kenichi YAMAKI, Ryujiro SUZUKI, Kenzo TAKAGI, Hitoshi TANAKA, Masatoshi IMAI, Toshiaki TSUNODA, Yoshiaki WATANABE, Toshihiko TAKEUCHI, Yoshimitsu HAYASHI, Kazuhide YAMAMOTO, Yasuo YAMADA, Fumiyuki KUZE, Takako MURAYAMA, Katsuhiro SUZUKI, Motokazu KATO, Masaru CHIBA, Riyo YAMAGUCHI, Hitoshi NAGAI, Fumikazu UMEDA, Hiromi TOMIOKA, Osamu EBISUI, Hironobu IWASAKI, Kenji BANDO, Takashi NISHIMURA, Tatsuki OYAIZU, Sunao ISHIDA, Shunsaku OHSHIMA, Masao KADO, Hirotaka YASUBA, Kikuo SUGIMOTO, Seibun YONEZU, Yoshihiro UEDA, Kojiro YASUNAGA, Fumio MIKI, Eiro TSUBURA, Masaru NAKAGAWA, Takeshi OGURA, Fumitaka OGUSHI, Masashi KAWANISHI, Waka ICHIKAWA, Kazuhito MIZUNO, Seiko ISHIKAWA, Yoshihiro TAKISHITA, Hiroyasu BANDO, Yoshihiro HASHIMOTO, Nobuhiro NARITA, Masayoshi SAWAKI, Keiichi MIKASA, Mitsuru KONISHI, Toshiharu MATSUSHIMA, Makoto KIMURA, Masayasu KAWANISHI, Tadasu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Takao SASAKI, Yukio MATSUMOTO, Yuji SUGIMOTO, Yoshiro SAWAE, Toshiyuki ISHIMARU, Koji TAKAGI, Nobuyuki SHIMONO, Nobuaki SHIGEMATSU, Katsuro YAGAWA, Shinichiro HAYASHI, Kenji KONO, Keisuke ONUKI, Shinichi TOHARA, Seiji TAKEDA, Masahide TAKII, Katsumi OKUDAIRA, Akihiko SAKAUE, Koichi SHINOHARA, Kotaro OIZUMI, Yoichiro ICHIKAWA, Masashi KAWAHARA, Kohei HARA, Masaki HIROTA, Keizo YAMAGUCHI, Shigeru KONO, Hironobu KOGA, Mitsuo KAKU, Yasumasa DOTSU, Hiroshi YAMADA, Kiyoyasu FUKUSHIMA, Naofumi SUYAMA, Toshiaki HAYASHI, Keizo MATSUMOTO, Toshiaki YOSHIDA, Tsuyoshi NAGATAKE, Moritoshi AKIYAMA, Masakazu TAKASUGI, Mikio TAGUCHI, Kiwao WATANABE, Harumi SHISHIDO, Kiyoshi SHIMA, Shinobu TAKENAKA, Masaru NASU, Jun GOTO, Hideaki SHIGENO, Yoichiro GOTO, Takayoshi TASHIRO, Hiroyuki NAGAI, Toru YAMAZAKI, Mitsunobu AKASHI, Hiroshi FUKUHARA, Hiroshi KANESHIMA, Yuei IRABU, Katsuyoshi SHIMOJI, Keizo KITSUKAWA, Yoshiteru SHIGENO, and Nobuya OGAWA

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, education, Ceftazidime, CEFPIROME SULFATE, medicine, Humans, In patient, Clinical efficacy, Intensive care medicine, Respiratory Tract Infections, Aged, Aged, 80 and over, Respiratory tract infections, business.industry, Significant difference, General Medicine, Cefpirome, Middle Aged, Cephalosporins, Clinical trial, Anesthesia, Female, business, medicine.drug
Abstract

Efficacy and safety of a new injectable cephem antibiotic, cefpirome sulfate (hereafter, CPR), against respiratory tract infections were examined and compared with those of a control drug, ceftazidime (hereafter, CAZ). As a rule, CPR 0.5 g twice a day, 1.0 g twice a day, or CAZ 1.0 g twice a day (hereafter CPR 0.5 g group, CPR 1.0 g group, and CAZ group) was administered for 14 days and the following results were obtained. 1. The total number of cases was 470 (155 cases in the CPR 0.5 g group, 160 cases in the CPR 1.0 g group, and 155 cases in the CAZ group). Among them 390 cases were subjected to analyses of clinical efficacy by the efficacy evaluation committee (131 cases in the CPR 0.5 g group, 131 cases in the CPR 1.0 g group and 128 cases in the CAZ group). 2. Efficacy rates determined by the efficacy evaluation committee were 82.4% (108/131) for the CPR 0.5 g group, 81.7% (107/131) for the CPR 1.0 g group, and 83.6% (107/128) for the CAZ group. Efficacy rates determined by the physician in charge were 82.0% (105/128) for the CPR 0.5 g group, 80.5% (99/123) for the CPR 1.0 g group, and 88.5% (108/122) for the CAZ group. No statistically significant difference was observed among the 3 groups. In evaluation of equivalency, clinical efficacy for the CPR 0.5 g group and the CPR 1.0 g group determined by the clinical efficacy evaluation committee was proved to be statistically equivalent to that for the CAZ group. 3. In patients with pneumonia, efficacy rates determined by the efficacy evaluation committee were 87.1% (61/70) for the CPR 0.5 g group, 80.7% (71/88) for the CPR 1.0 g group, and 78.9% (56/71) for the CAZ group. Efficacy rates determined by the physician in charge were 85.3% (58/68) for the CPR 0.5 g group, 80.7% (67/83) for the CPR 1.0 g group, and 86.2% (56/65) for the CAZ group and no statistically significant difference was observed among the 3 groups. In patients with chronic respiratory tract infection, efficacy rates determined by the efficacy evaluation committee were 77.0% (47/61) for the CPR 0.5 g group, 83.7% (36/43) for the CPR 1.0 g group, and 89.5% (51/57) for the CAZ group. Efficacy rates determined by the physician in charge were 78.3% (47/60) for the CPR 0.5 g group, 80.0% (32/40) for the CPR 1.0 g group, and 91.2% (52/57) for the CAZ group. No statistically significant difference was observed among the 3 groups.(ABSTRACT TRUNCATED AT 400 WORDS)

Published
1991

9. [An optimum dose-finding study of HR810 (CPR) in chronic respiratory tract infections]

Author

Rinzo SOEJIMA, Jiro HINO, Masaru SUMI, Niro OKIMOTO, Susumu YAGI, Kuninori TSUKIYAMA, Toshiharu MATSUSHIMA, Masayoshi KAWANISHI, Yohmei HIRAGA, Mitsuhide OHMICHI, Akira WATANABE, Kotaro OIZUMI, Yoshihiro HONDA, Yutaka TOKUE, Masakichi MOTOMIYA, Kazuo SATO, Kosaku NAGAI, Shigeru SHIMODA, Kiyoshi KONNO, Izumi HAYASHI, Hiroshi OSHITANI, Hiroshi MIURA, Takashi INOUE, Hiroyuki KOBAYASHI, Kaoru SHIMADA, Takashi INAMATSU, Mieko GOTO, Shinichi OKA, Hajime GOTO, Yoshitaka NAKAMORI, Koji NARUI, Masayuki NOGUCHI, Tatsuo NAKAYA, Koichiro NAKATA, Iwao SAKURAI, Takeo IMAI, Fumio MATSUMOTO, Shigeki ODAGIRI, Kaneo SUZUKI, Kou MUROHASHI, Hiroshi TAKAHASHI, Yasuhiko ASHIKARI, Izumi KOYAMA, Toshikazu ISHII, Eiro TSUBURA, Masaru NAKAGAWA, Hideki NISHIKAWA, Yoshihiro TAKISHITA, Hiroyasu BANDO, Yoshihiro HASHIMOTO, Shinji ATAGI, Yukio MATSUMOTO, Mitsunobu YAMAMOTO, Tatsuya KONISHI, Yuji SUGIMOTO, Takuya SAKATA, Hiroaki HIRAI, Yutaka HITSUDA, Takao SASAKI, Kohei HARA, Masaki HIROTA, Shigeru KOHNO, Toshiaki HAYASHI, Naofumi SUYAMA, Yukishige MIYAZAKI, Yasumasa DOHTSU, Akira YASUOKA, Tatsuya KATSUMATA, Hiroshi YAMADA, Toshiaki YOSHIDA, Tsuyoshi NAGATAKE, Moritoshi AKIYAMA, Masakazu TAKASUGI, Mikio TAGUCHI, Kiwao WATANABE, Keizo MATSUMOTO, Masaru NASU, Jun GOTO, Hideaki SHIGENO, Yoichiro GOTO, Takayoshi TASHIRO, Hiroyuki NAGAI, Toru YAMAZAKI, Mitsunobu AKASHI, Atsushi SAITO, Hiroshi FUKUHARA, Hiroshi KANESHIMA, Yuei IRABU, Katsuyoshi SHIMOJI, Keizo KITSUKAWA, Yoshiteru SHIGENO, and Nobuya OGAWA

Subjects
Adult, Male, Adolescent, Ceftazidime, law.invention, Random Allocation, Randomized controlled trial, law, CEFPIROME SULFATE, medicine, Humans, Respiratory Tract Infections, Aged, Aged, 80 and over, Chi-Square Distribution, Respiratory tract infections, business.industry, Incidence (epidemiology), General Medicine, Middle Aged, Cephalosporins, Clinical trial, Diarrhea, Anesthesia, Chronic Disease, Drug Evaluation, Female, medicine.symptom, business, Chi-squared distribution, medicine.drug
Abstract

In order to determine the optimal dose of cefpirome sulfate (HR810, CPR) against respiratory tract infections (RTI), an optimal dose-finding study was conducted on cases of chronic RTI, and the clinical properties of the drug were compared with those of ceftazidime (CAZ). Inpatients with chronic RTI were randomly assigned to 3 groups: an HR 0.5 g group, receiving 0.5 g X 2/day of CPR an HR 1.0 g group, receiving 1.0 X 2/day of CPR and a CAZ group, receiving 1.0 g X 2/day of CAZ. As a rule, the drugs were administered by intravenous drip infusion for 14 days, after which period clinical efficacy, bacteriological response, safety, and utility were investigated. Of the total 121 cases, 106 were subject to analysis of clinical efficacy, including 38 cases in the HR 0.5 g group, 32 in the HR 1.0 g group, and 36 in the CAZ group. Efficacy rates in the assessment by the committee were 84.2% for the HR 0.5 g group, 75.0% for the HR 1.0 g group, and 86.1% for the CAZ group, without any significant difference between the 3 groups. The bacterial elimination rates were 73.9%, 75.0% m and 88.5%, respectively, without any significant difference between the 3 groups. Associated reactions were noted in 2 of 36 cases in the HR 1.0 g group (eruption and diarrhea), but not in the other 2 groups. The incidence of abnormal clinical laboratory findings was 23.1% in the HR 0.5 g group, 22.2% in the HR 1.0 g group, and 22.5% in the CAZ group, without any significant difference between the 3 groups. Utility rates were 84.2% for the HR 0.5 g group, 74.2% for the HR 1.0 g group, and 86.1% for the CAZ group, without any significant difference between the 3 groups. The HR 0.5 g and 1.0 groups showed no difference in clinical efficacy, bacteriological response, safety, and utility against RTI, and the results of both groups were about equal to those of the CAZ group.

Published
1991

10. Immunological Studies on Whole Saliva

Author

Eiro Tsubura, Yoshihiro Takishita, Katsuhito Kozai, Michiaki Kawano, Toshihiro Goto, and Tomio Tsukuda

Subjects
Immunoglobulin A, biology, business.industry, Immunology, biology.protein, Medicine, General Medicine, Whole saliva, business
Published
1977
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11. [Untitled]

Author

Eiro Tsubura, Masakazu Tamura, Toshihiro Goto, and Yoshihiro Takishita

Subjects
biology, Chemistry, Immunology, Lymphokine, Macrophage, Candida albicans, biology.organism_classification, Function (biology), Microbiology
Published
1979
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12. Comparative Study of the Effectiveness of Mezlocillin and Ampicillin on Respiratory Tract Infection

Author

Kuninori Suzuki, Fumiro Tanaka, Mikihiko Tango, Hidetoshi Shibaki, Tadanori Kondo, Tadashi Miyazawa, Osamu Hagiwara, Nobuki Aoki, Fumio Nagahama, Ryuzo Fueki, Kenzo Shiota, Hajime Watanabe, Shigechika Kado, Hideo Sasaki, Hiroshi Takagi, Osamu Kitamoto, Akira Kinoshita, Haruaki Ichimaru, Akihiko Kuze, Morikuni Abe, Yoshihiro Takihara, Yutaka Motohashi, Keimei Mashimo, Masao Nagasawa, Kanzo Suzuki, Tadashi Miyahara, Kyuichiro Sekine, Masumi Tomizawa, Shinya Yasuda, Kaori Yasuda, Hiroshi Suzuki, Hiroyuki Kobayashi, Masaru Koyama, Takashi Nakagawa, Naoyoshi Masaki, Sumio Yamaoka, Setsuo Kobayashi, Mitsuo Masuda, Yukio Nishimoto, Masataka Katsu, Kaoru Oyama, Fumio Miki, Munetaka Komori, Yoshiro Sawae, Tohru Nagasawa, Hiroshi Okubo, Norichika Matsumoto, Izumi Hayashi, Masakatsu Nishida, Kei Yaguchi, Kohzo Mori, Hiroichi Tanimoto, Kiyoshi Konno, Kohei Hara, Kokichi Fukushima, Ippei Fujimori, Hideo Ohzeki, Osamu Abe, Masao Nakatomi, Yoshihiro Kumasaka, Yuruko Okamoto, Masayuki Tachibana, Toyokazu Tamura, Masaro Kaji, Toshio Kobayashi, Akio Tachibana, Kazuo Kondo, Keiko Iwamoto, Norio Inaba, Kazuyoshi Watanabe, Kentaro Watanabe, Saburo Kurematsu, Keizo Matsumoto, Tetsuharu Tanaka, Tetsuo Komori, Yoshinobu Takashiro, Mitsuo Obana, Takahiko Konno, Sumio Arai, Chie Karibe, Junzaburo Kabe, Mitsuo Hase, Kunio Dobashi, Makio Kurihara, Toshihiro Goto, Masahisa Ohmori, Yoichi Miyahara, Fusanosuke Yamasaku, Akira Ujiie, Shinichi Tomioka, Naofumi Suyama, Tsugio Nakazawa, Hideo Aoki, Eiji Nakamura, Shigeru Matsumoto, Hiroshi Nagano, Akira Saito, Naomi Kodomari, Kazunori Harada, Shigeharu Morioka, Yomei Hiraga, Takehisa Yamaji, Kohya Shiba, Osamu Kurimura, Nobuo Maekawa, Kazutoyo Kaneko, Kozue Komori, Hidero Nakazono, Keiichi Nakagawa, Takashi Watanabe, Shuichiro Yoshida, Kotaro Oizumi, Kiyoko Sakai, Yoshito Niki, Yoichiro Ichikawa, Okui S, Takafumi Yano, Tsuneharu Baba, Kunihiko Shindo, Kazue Sadamoto, Rinzo Soejima, Michiyasu Nakanishi, Motoichi Tanaka, Takaaki Akagawa, Masafumi Kitaoka, Masami Arakawa, Katsuhiko Matsui, Hideyuki Hasegawa, Katsuhiro Okamoto, Hironobu Ihara, Toshiyuki Yamamoto, Toshio Hojo, Kenji Takamatsu, Jingoro Shimada, Kaoru Okada, Sumio Kishimoto, Hideo Ikemoto, Yasunori Tanaka, Hiroshi Minami, Yoshihiro Takishita, Hiroyasu Kawabe, Mitsuharu Ogi, Ryoichi Amitani, Mamoru Yamada, Yoshiro Mochizuki, Michio Yamakido, Eiro Tsubura, Shunji Hayashi, Akira Ito, Katsumi Endo, Fumiaki Uchihira, Takashi Akiyama, Ichiro Nakayama, Masami Ueda, Atsushi Shimomura, Yoshiro Oda, Hiroshi Fukui, Yuichi Koizumi, Kazuo Takebe, Ken-ichi Imamura, Kenji Saeki, Yasuyoshi Sakurai, Yayoi Okawa, Atsushi Saito, Takuro Matsumoto, Shigeki Odagiri, Ken Osonoi, Mitsuko Takamura, Tamotsu Takishima, Akio Aoyagi, Kazuki Konishi, Keigo Maehara, Tatsuo Saito, Koichiro Nakada, Tatsuya Ohnuki, Takehito Nakabayashi, Yoshio Kinoshita, Tadashi Takigami, Yoshimaru Usuda, Hiroyuki Doi, Kiyofumi Ishikawa, Akira Yokoyama, Seiichi Murakami, Yoshio Kobayashi, Osamu Sekine, Kawai M, Hisashi Nakahata, and Toshikazu Nemoto

Subjects
medicine.medical_specialty, Mezlocillin, medicine.anatomical_structure, business.industry, Internal medicine, Ampicillin, medicine, General Medicine, business, Gastroenterology, medicine.drug, Respiratory tract
Published
1981
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13. A case of portal hypertension of vinyl chloride worker

Author

Kunihiko Harada, Yoshihiro Takishita, Eiro Tsubura, Akio Nagamatsu, Hisashi Otsuka, and Goro Hisano

Subjects
chemistry.chemical_compound, medicine.medical_specialty, Hepatology, chemistry, business.industry, Internal medicine, medicine, Portal hypertension, business, medicine.disease, Gastroenterology, Vinyl chloride
Abstract

塩化ビニール・モノマーの暴露が関係していると思われる門脈圧亢進症の1例について報告する. 症例は38歳の男性で,18年9カ月間にわたり塩化ビニール製造作業に従事していたが,脾腫,食道および胃の静脈瘤を伴う門脈圧亢進症と診断され脾摘出術および食道離断術を受けた.術前の検査では血小板数の減少,ICGおよびBSPによる色素排泄能の障害が認められたが,GOT,GPT,およびアルカリフォスファターゼ値は正常であった.肝の組織学的検査では門脈域の線維化が著しく,小葉間におよぶ線維性の隔壁があり,類洞内皮細胞の僅かな増加がみられた.摘出脾では著明な慢性うっ血像を示し,脾洞の増生,髄索および血管周囲の線維化がみられた.患者は術後8カ月目に絞拒性腸閉塞で同部の切除術を受けたが,術後に腎不全および汎発性腹膜炎で死亡した.

Published
1977
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14. Phycomycosis in Intestine Complicated wite Acute Leukemia

Author

Eiro Tsubura, Takeshi Tsutsumi, Yoshihiro Takishita, Masakazu Tamura, Kentaro Yata, and Saburo Sone

Subjects
Antifungal, medicine.medical_specialty, Acute leukemia, Ileus, medicine.drug_class, business.industry, Surgical removal, medicine, Etiology, Acute lymphogenous leukemia, medicine.disease, business, Surgery
Abstract

During the course of acute lymphogenous leukemia, obstructive ileus developed to be operable. Phycomycosis was detected histologically in the resected intestinal wall and mesenterial tissue. No other etiological agents could be detected. The cause of invasion of phycomycosis was considered to be due to the immunosuppressed status of the patient. Surgical removal of the infected area and successful antifungal treatment prevented the fungal dissemination.

Published
1977
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16. 2 CASES OF SELECTIVE IMMUNOGLOBULIN A DEFICIENCY

Author

Tadamitsu Kishimoto, Eiro Tsubura, Atsushi Muragughi, Masakazu Tamura, T. Nakayama, Toshio Hirano, Toshihiro Goto, Yuichi Yamamura, Taro Kuritani, and Yoshihiro Takishita

Subjects
business.industry, Immunology, Medicine, General Medicine, business, Immunoglobulin A deficiency
Published
1978
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17. Comparative Study of the Effectiveness of Cefotaxime and Cefazolin on Respiratory Tract Infection

Author

Tadashi Miyazawa, Yoshihiro Ueda, Toshio Fujioka, Seiichi Honma, Kaoru Oyama, Yasutoshi Suzuki, Takehito Nakamura, Shiro Kosaka, Tsukasa Yoshida, Mitsunobu Akashi, Takashi Watanabe, Tadashi Miyahara, Ryoji Ohashi, Tamotsu Takishima, Akio Aoyagi, Fumio Miki, Kohei Hara, Shinichi Morinaga, Koya Shiba, Morikuni Abe, Gen Tajima, Okui S, Fumio Nagahama, Yasutsugu Fukuda, Kosuke Nakazawa, Takamitsu Kido, Shuichiro Yoshida, Susumu Suetsugu, Kuninori Suzuki, Kazuki Miura, Makoto Imaoka, Teruo Katayama, Keiko Cho, Masahito Okayasu, Takashi Ito, Toshio Hojyo, Michiyasu Nakanishi, Mitsuo Nakamura, Masumi Tomizawa, Kotaro Oizumi, Hironobu Ihara, Ryutaro Kiuchi, Nobuki Aoki, Kiyoshi Konno, Yoichiro Ichikawa, Masanaga Takato, Jingoro Shimada, Tsuneo Tsutsumi, Yoshito Niki, Ryuzo Fueki, Koichi Watanabe, Masayuki Ando, Takehumi Kunieda, Kenji Kubo, Keisuke Nishiwaki, Yoshio Kobayashi, Yasuo Nomura, Ko Fujii, Takekuni Iwata, Masatoshi Ide, Harumi Shishido, Nobuharu Oe, Yoshio Hoshihara, Sumio Yamaoka, Yoji Suzuyama, Takehisa Yamaji, Kazuhiko Hagane, Kazuo Sasaki, Koichiro Nakada, Shuzo Sakai, Katsuhiro Okamoto, Hiromi Asakura, Yoshioki Niwa, Toshiyuki Yamamoto, Mitsuru Iwakura, Kazue Sadamoto, Rinzo Soejima, Kosho Yoshikawa, Keiichi Nakagawa, Tatsuo Suzuki, Yukio Nishimoto, Kunio Kudo, Yoshihiro Kumasaka, Yoshio Kinoshita, Masataka Katsu, Tadashi Takigami, Yoshimaru Usuda, Hiroshi Okubo, Hisao Kimura, Kaoru Okada, Shinichi Matsuo, Hiroichi Tanimoto, Akira Saito, Osamu Sekine, Ippei Fujimori, Kaoru Shimada, Akio Tachibana, Katsuhiko Matsui, Yomei Hiraga, Hisashi Nakahata, Izumi Hayashi, Yoshiteru Shigeno, Noboru Shimizu, Masahisa Omori, Kenichi Kimura, Hiromi Kato, Atsushi Saito, Yoshihiko Matsuda, Rokushi Oka, Michio Yamakido, Masahito Kato, Eiro Tsubura, Otohiko Kunii, Shigeru Miyano, Akira Ujiie, Atsushi Shimomura, Hiroshi Nagano, Toshiro Oda, Jutaro Shimomura, Kazuo Horie, Haruhiko Tokuomi, Shoko Narita, Kazuo Takebe, Keiji Takahashi, Mitsuko Takamura, Kazufuto Fukaya, Ken-ichi Imamura, Masao Nakatomi, Keigo Maehara, Masaru Nasu, Toshiyuki Maeda, Katsumasa Tokunaga, Yasuo Matsuoka, Shoji Yasui, Tsuneo Matsubara, Ryokichi Takasugi, Hajimu Takeda, Kenzo Shiota, Takafumi Yano, Kiyoya Izumi, Shigeru Nagaoka, Genichi Tanaka, Hiroshi Okano, Tetsuaki Inokuchi, Kozo Mori, Yasushi Yamada, Seiichi Murakami, Osamu Kitamoto, Makoto Fukui, Shinya Yasuda, Yasumichi Kato, Hideo Ikemoto, Fumihiko Uba, Mitsuaki Yoshioka, Yasuhiro Kawabe, Hirohiko Nagasaka, Hiromichi Umeda, Hiroyuki Kobayashi, Keizo Matsumoto, Nobuaki Tsuzuki, Yoshiro Sawae, Takeshi Mashima, Toshikatsu Kato, Tomohiro Kanazawa, Sumio Arai, Kiyohito Takahashi, Kiyofumi Ishikawa, Junzaburo Kabe, Keimei Mashimo, Setsuo Kobayashi, Norio Kihara, Toshihiko Yoshiga, Shigechika Kado, Hideo Sasaki, Fusanosuke Yamasaku, Kazuhiko Ito, Mikihiko Kudo, Saburo Yano, Yuruko Okamoto, Tsunetoshi Koteda, Nobuo Maekawa, Masanori Morise, Masaro Kaji, Kazuyoshi Watanabe, Yoshihiro Takishita, Masanori Adachi, Yoshihiko Tano, Yasuko Yuasa, Kinichi Izumikawa, Hideyo Noguchi, and Osamu Kurimura

Subjects
medicine.anatomical_structure, Cefotaxime, business.industry, Anesthesia, Cefazolin, medicine, General Medicine, business, medicine.drug, Respiratory tract
Published
1980
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18. Comparative Clinical Study of Cefpiramide (SM-1652) and Cefmetazole for Respiratory Tract Infections by a Double-Blind Method

Author

Hiroyuki KOBAYASHI, Osamu KITAMOTO, Akira SAITO, Yasumichi KATO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Morikuni ABE, Akira UJIIE, Yoshio KINOSHITA, Osamu YAJIMA, Fumio NAGAHAMA, Yuichi SASAKI, Shinya YASUDA, Takehito NAKABAYASHI, Takahisa SAITO, Satoshi YAGUCHI, Kazuo SAOTOME, Yuji IKEDA, Jutaro SHIMOMURA, Mitsuharu OGI, Hiroshi TAKAGI, Akihiko KUZE, Osamu MITSUHASHI, Takashi TAKABORI, Yomei HIRAGA, Kohki KIKUCHI, Hiroshi KAWAI, Kazuo TAKEBE, Kenichi IMAMURA, Yoshihiro KUMASAKA, Kiyohito TAKAHASHI, Hisashi NAKAHATA, Mitsuo NAKAMURA, Takashi CHINOI, Katsuhiro OKAMOTO, Shuichiro YOSHIDA, Naoyoshi MASAKI, Toyokazu TAMURA, Tadashi MIYAZAWA, Hazime WATANABE, Shiro KOSAKA, Makoto NAKAZONO, Tsuneharu BABA, Kazuo SASAKI, Morio SAGARA, Hitoshi YASHIRO, Osamu UEHARA, Masao TAMURA, Ryuji ITO, Taro CHIBA, Kazuki KONISHI, Toshimi SUZUKI, Yoshiaki TAKEZAWA, Yasuo ONO, Hisao KIMURA, Tamotsu TAKISHIMA, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Seiichi AONUMA, Kikuo ONUMA, Izumi HAYASHI, Tatsuya ABE, Masataka KATSU, Kenichi OKAYAMA, Kunio IMATAKA, Masanori ADACHI, Fuyuhiko HIGASHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Junko HIBINO, Yasushi UEDA, Atsushi SAITO, Masanobu KAJI, Tadashi MIYAHARA, Ryozo YONEDA, Mitsuo KAWAMURA, Sumio YAMAOKA, Keimei MASHIMO, Keiichi NAKAGAWA, Masaru KOYAMA, Kentaro WATANABE, Motoichi TANAKA, Shinichi ODAMA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Hiroichi TANIMOTO, Akio TACHIBANA, Ippei FUJIMORI, Michinori KOHNO, Yoshio KOBAYASHI, Toshio FUKUI, Kenji MITSUI, Kokichi FUKUSHIMA, Akira ITHO, Kunihiko SHINDO, Shigeki ODAGIRI, Makio KURIHARA, Hideyuki HASEGAWA, Kazufuto FUKAYA, Hajimu TAKEDA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Kaoru OHYAMA, Kuniyoshi SUZUKI, Ryusaku SHIMIZU, Toshiyuki YAMAMOTO, Saburo KITAURA, Masahito KATO, Kenzo SUZUKI, Kazuo YOSHITOMO, Motoko YAMAMOTO, Akihiko KISHIMOTO, Nobuo MAEKAWA, Michiyasu NAKANISHI, Takekuni IWATA, Mitsuo HASE, Ryoichi AMIYA, Yoichi OSADA, Hiroshi OKUBO, Yuruko OKAMOTO, Yoshihiro UEDA, Keigo MAEHARA, Fumio MIKI, Rinzo SOEJIMA, Yoshito NIKI, Masayasu KAWANISHI, Chikara NAKAHAMA, Yukio NISHIMOTO, Michio YAMAKIDO, Fumiaki TSUKIYAMA, Osamu KURIMURA, Hideo SASAKI, Yoshihiko ARAYA, Yoko KAGAWA, Eiro TSUBURA, Toshihiro GOTO, Yoshihiro TAKISHITA, Yoshiro SAWAE, Kaoru OKADA, Nobuaki SHIGEMATSU, Osamu OGUSHI, Kohei HARA, Tsuneo TSUTSUMI, Kazuhiro OKUNO, Rokushi OKA, Keizo YAMAGUCHI, Youji SUZUYAMA, Toshiyuki OE, Yoshiteru SHIGENO, Naomi ITOH, Hikaru TANAKA, Masao SAI, Keizo MATSUMOTO, Harumi SHISHIDO, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Atsushi SHINODA, Hitoshi NAGANO, Toshiyuki HAYASHI, Haruhiko TOKUOMI, Yasutsugu FUKUDA, and Katsumasa TOKUNAGA

Subjects
Double blind, Clinical study, medicine.medical_specialty, Respiratory tract infections, business.industry, Internal medicine, medicine, General Medicine, Cefpiramide, Cefmetazole, business, Gastroenterology, medicine.drug
Published
1983
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19. Comparative Test of the Effectiveness of Cefoperazone (T-1551) and Cefazolin (CEZ) on Respiratory Tract Infection by Double Blind Method (II)

Author

Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Norio KIHARA, Tatsuo SUZUKI, Akira FUKUI, Yasumichi KATO, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Yoshio KINOSHITA, Kiyofumi ISHIKAWA, Fumio NAGAHAMA, Takehito NAKABAYASHI, Shinya YASUDA, Tetsuji KOROKU, Takahisa SAITO, Kazunori HARADA, Hiroshi KON, Takashi MIKAMI, Nobuo WATANABE, Yasumasa YOKOTA, Toshio KIRISAWA, Akira NAKASATO, Akira SASAKI, Masataka ITO, Ryuji SATO, Kazuo TAKEBE, Yoshihiro KUMASAKA, Hisashi NAKAHATA, Shiro KOSAKA, Mitsuo NAKAMURA, Kenichi IMAMURA, Koji MACHIDA, Kazuo SASAKI, Katsuhiro OKAMOTO, Shuichiro YOSHIDA, Hiroyasu KAWABE, Mitsuaki YOSHIOKA, Shokou NARITA, Masahiro TSUTSUI, Tamotsu TAKISHIMA, Sumio ARAI, Kazuki KONISHI, Tadashi TAIMA, Nobuo SATO, Hajime TAKEDA, Masatoshi NIWAYAMA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Yasuko YUASA, Izumi HAYASHI, Masataka KATSU, Mieko KAWAI, Teruo AOYAGI, Noboru YANAI, Iwao TAKANAMI, Masashi MOURI, Otohiko KUNII, Kazufuto FUKAYA, Yasushi UEDA, Atsushi SAITO, Jingoro SHIMADA, Masahisa OOMORI, Kooya SHIBA, Takehisa YAMAJI, Hironobu IHARA, Toshio HOJO, Tadashi MIYAHARA, Hiroichi TANIMOTO, Akio TACHIBANA, Koichiro NAKADA, Mikizo SUZUKI, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Keimei MASHIMO, Sumio YAMAOKA, Junzaburo KABE, Osamu KITAMOTO, Hiroyuki KOBAYASHI, Hideo IKEMOTO, Ikko WATANABE, Terumi TAKAHASHI, Touji ODAGIRI, Ippei FUJIMORI, Yasuo MASTUOKA, Yoshio KOBAYASHI, Kojiro SEKITA, Kenji MITSUI, Kokichi FUKUSHIMA, Akira ITO, Hideyuki HASEGAWA, Koichi YAMANAKA, Kunihiko SINDO, Ryuichiro YAMASAKI, Makio KURIHARA, Takashi SUYAMA, Raiji YAMAMOTO, Yukihiko OBIGANE, Shizuo ABE, Tadashi TAKIGAMI, Kaoru OYAMA, Kuninori SUZUKI, Masao KUROSAKI, Mitsuru HAYASE, Nobuo OOYA, Toshiyuki YAMAMOTO, Masahito KATO, Hirohiko NAGASAKA, Kozo MORI, Saburo KITAURA, Kunio NANJO, Joichi KATO, Nobuo MAEKAWA, Michiyasu NAKANISHI, Nobuo INABA, Yoshiro ODA, Kenzo SHIOTA, Fumio MIKI, Akira OKUBO, Yuruko OKAMOTO, Fumihiko UBA, Yoshihiro UEDA, Keigo MAEHARA, Rinzo SOEJIMA, Toshiharu MATSUSHIMA, Yoshihiko TANO, Yoshito NIKI, Susumu YAGI, Hironori HARA, Kyosei SODA, Naomi KIMURA, Takanobu MATSUMOTO, Hiroshi SEWAKE, Mitsue NISHIMURA, Mikio HAYAKAWA, Hiromichi KUNIKI, Osamu KURIMURA, Kazue SADAMOTO, Hideo SASAKI, Eiro TSUBURA, Yoshihiro TAKISHITA, Toshihiro GOTO, Yoshiro SAWAE, Kaoru OKADA, Tsuneo ISHIBASHI, Masanori TAKAMOTO, Fumihiko MAEDA, Tetsuo FUJIKI, Minoru YOSHIDA, Hitoshi NAGANO, Shinichi MATSUO, Kohei HARA, Masao NAKATOMI, Masaru NASU, Tsuneo TSUTSUMI, Yoshiteru SHIGENO, Masaki HIROTA, Keizo MATSUMOTO, Harumi SHISHIDO, Hisao KIMURA, Kouichi YOKOYAMA, Masato HAYASHI, Chiyohiko SHINDO, Haruhiko TOKUOMI, Yasutsugu FUKUDA, Katsumasa TOKUNAGA, Kiyoshi SHIMA, and Teruya ICHIKI

Subjects
Cefoperazone, Chemistry, Anesthesia, Cefazolin, medicine, General Medicine, medicine.drug
Published
1980
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20. Secretory-component-producing lung cancer with hypergammaglobulinemia of secretory IgA

Author

Toshihiro Gotoh, Hiroyuki Doi, Eiro Tsubura, and Yoshihiro Takishita

Subjects
Male, Cancer Research, Pathology, medicine.medical_specialty, Lung Neoplasms, Secretory component, Adenocarcinoma, Hypergammaglobulinemia, medicine, Adenocarcinoma of the lung, Humans, Lung cancer, Lymph node, Immunoelectrophoresis, Immunoglobulin Fragments, Aged, business.industry, Cancer, Immunoglobulin D, medicine.disease, Carcinoembryonic Antigen, Immunoglobulin A, Secretory Component, Radiography, medicine.anatomical_structure, Oncology, Immunoglobulin M, Immunoglobulin G, Cancer cell, Immunoglobulin A, Secretory, Chromatography, Gel, business
Abstract

Studies were made on a case of well-differentiated adenocarcinoma of the lung in which the serum levels of secretory IgA (sIgA) were very high. Immunofluorescent studies showed that secretory component (SC) was found to be diffusely distributed in cancer cells. The SC was detected in the supernatant of homogenates of cancer tissues from the primary site and lymph node with metastases. The SC extracted from cancer tissue and purified colostral SC were antigenically identical. The authors conclude that the adenocarcinoma cells produced SC and secreted it into the bloodstream and that the binding of SC with polymeric IgA resulted in the hypergammaglobulinemia of sIgA. This appears to be the first reported case of SC-producing lung cancer. The authors' findings suggest that the high serum levels of sIgA in cancer patients may be due to the production and secretion of SC by tumor cells themselves rather than the reabsorption of intraluminal sIgA into the circulation through a damaged epithelium.

Published
1981

21. [A case of rheumatoid arthritis with interstitial pneumonitis followed by polymyositis]

Author

Yoshihiro Takishita, Shinji Atagi, Yoshihiro Hashimoto, Hiroyasu Bando, and Uichiro Tezuka

Subjects
medicine.medical_specialty, Myositis, business.industry, Prednisolone, Pulmonary Fibrosis, MEDLINE, Arthritis, General Medicine, Middle Aged, medicine.disease, Dermatology, Polymyositis, Interstitial pneumonitis, Arthritis, Rheumatoid, Rheumatoid arthritis, medicine, Humans, Female, business
Abstract

症例は60才,女性.昭和61年,アメリカリウマチ学会の診断基準でdefinite RA, stage IIIと診断.同年末頃,間質性肺炎を発症.昭和62年12月,筋肉痛,筋力低下が出現し,検査の結果,厚生省特定疾患調査研究班の診断基準を満たす多発性筋炎と診断.本邦では,慢性関節リウマチと多発性筋炎あるいは皮膚筋炎の合併は自験例を含め10例が報告されているにすぎず,全例が女性で肺線維症,間質性肺炎, ARDSなどの肺病変を含併していた.

Published
1989

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