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3. Guidance on the need for contraception related to use of pharmaceuticals: the Japan Agency for Medical Research and Development Study Group for providing information on the proper use of pharmaceuticals in patients with reproductive potential

Author

Suzuki, Nao, Takai, Yasushi, Yonemura, Masahito, Negoro, Hiromitsu, Motonaga, Shinya, Fujishiro, Noriko, Nakamura, Eishin, Takae, Seido, Yoshida, Saori, Uesugi, Koji, Ohira, Takashi, Katsura, Aiko, Fujiwara, Michio, Horiguchi, Itsuko, Kosaki, Kenjiro, Onodera, Hiroshi, and Nishiyama, Hiroyuki

Published
2022
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5. Efficacy of Cisplatin–CXCR4 Antagonist Combination Therapy in Oral Cancer.

Author

Yoshida, Saori, Kawai, Hotaka, Soe, Yamin, Eain, Htoo Shwe, Sanou, Sho, Takabatake, Kiyofumi, Takeshita, Yohei, Hisatomi, Miki, Nagatsuka, Hitoshi, Asaumi, Junichi, and Yanagi, Yoshinobu

Subjects
*THERAPEUTIC use of antineoplastic agents, *SQUAMOUS cell carcinoma, *IN vitro studies, *MOUTH tumors, *CISPLATIN, *DRUG resistance in cancer cells, *T-test (Statistics), *RESEARCH funding, *NECROSIS, *CELL proliferation, *NEOVASCULARIZATION inhibitors, *XENOGRAFTS, *CANCER patients, *DESCRIPTIVE statistics, *MICE, *CELL lines, *DRUG efficacy, *ANIMAL experimentation, *CHEMOKINE receptors, *DATA analysis software, *COMPARATIVE studies, *DISEASE progression, *HEMORRHAGE, *CHEMICAL inhibitors
Abstract

Simple Summary: Some cases of oral cancer are inoperable, and some of these cases also show a limited response to cisplatin. The chemokine receptor CXCR4 has been shown to be involved in tumor growth and metastasis via tumor angiogenesis, and its expression on oral squamous cell carcinoma (OSCC) cells was associated with recurrence and lymph node metastasis. Therefore, we investigated the effects of adding the CXRC4 inhibitor AMD3100 to cisplatin on OSCC cells in vitro and in mouse xenograft models in vivo. The addition of AMD to cisplatin had no additional anti-tumor effect in vitro, but improved the anti-tumor effect of cisplatin and reduced the number of CXCR4-positive blood vessels in cisplatin-resistant OSCC xenografts in vivo. These findings suggest that the addition of a CXCR4 inhibitor may increase the anti-tumor effects of cisplatin in patients with refractory OSCC. Cisplatin is a platinum-based compound that is widely used for treating inoperable oral squamous cell carcinoma (OSCC) in Japan; however, resistance to cisplatin presents a challenge and innovative approaches are required. We aimed to investigate the therapeutic potential of targeting the chemokine receptor CXCR4, which is involved in angiogenesis and tumor progression, using the CXCR4 inhibitor AMD3100, in combination with cisplatin. AMD3100 induced necrosis and bleeding in OSCC xenografts by inhibiting angiogenesis. We investigated the combined ability of AMD3100 plus cisplatin to enhance the antitumor effect in cisplatin-resistant OSCC. An MTS assay identified HSC-2 cells as cisplatin-resistant cells in vitro. Mice treated with the cisplatin-AMD combination exhibited the most significant reduction in tumor volume, accompanied by extensive hemorrhage and necrosis. Histological examination indicated thin and short tumor vessels in the AMD and cisplatin–AMD groups. These results indicated that cisplatin and AMD3100 had synergistic antitumor effects, highlighting their potential for vascular therapy of refractory OSCC. Antitumor vascular therapy using cisplatin combined with a CXCR4 inhibitor provides a novel strategy for addressing cisplatin-resistant OSCC. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Influence of mandibular incisor agenesis and growth pattern on symphysis characteristics: A retrospective cephalometric study.

Author

Yoshida, Saori, Ota, Shin, and Kobayashi, Sakurako

Subjects
TWO-way analysis of variance, ALVEOLAR process, INCISORS, HYPODONTIA
Abstract

Objective: This study was performed to investigate the effects of mandibular incisor (MnI) agenesis and divergent malocclusion type on mandibular symphysis inclination and morphology. Methods: A total of 162 selected patients were divided into two groups: one group consisted of patients with one or two congenitally missing MnIs, and another group comprised patients without tooth agenesis. Patients in each group were categorized into three divergent malocclusion groups (hypodivergent, normodivergent and hyperdivergent) according to the Frankfort mandibular plane angle, with 27 patients per group. Lateral cephalograms were used to evaluate mandibular symphysis inclination and morphology. Two‐way analysis of variance, simple main effect analysis and Tukey's test were used for statistical comparisons. Results: The agenesis group demonstrated a significantly greater retroclination of the mandibular symphysis than the non‐agenesis group in the normodivergent group. In the hypodivergent and normodivergent groups, the agenesis group showed a significantly smaller area of the alveolar bone with thinner width and shorter height than the non‐agenesis group. Conclusion: For the Japanese orthodontic patients, MnI agenesis caused a significantly great retroclination of the mandibular symphysis in patients with normodivergent malocclusion and significantly small area of the alveolar bone with thin width and short height in patients with hypo‐ and normodivergent malocclusions. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Robust magnetic domain of Pt/Co/Au/Cr2O3/Pt stacked films with a perpendicular exchange bias.

Author

Shiratsuchi, Yu, Yoshida, Saori, Yoshida, Hiroaki, Kotani, Yoshinori, Toyoki, Kentaro, Nakatani, Ryoichi, Mitsumata, Chiharu, and Nakamura, Tetsuya

Subjects
*MAGNETIC domain, *MAGNETIC domain walls, *DOMAIN walls (String models), *MAGNETIZATION
Abstract

Magnetic domain pattern and magnetic domain wall motion are particularly important to understand the magnetization process. Here, we investigated the magnetization process of perpendicularly exchange-biased Pt/Co/Au/Cr2O3/Pt stacked films based on observations of the magnetic domain. In particular, in contrast to previous studies which use fully exchange-biased state, we used the bi-exchange-biased state. We found that the magnetic domain pattern at the remanent state was robust against magnetic-field cycling, which is relevant to the absence of the training effect. The magnetization process was followed by domain wall propagation in the increasing branch of the magnetization curve. In the decreasing branch, both nucleation of the reversed domain and domain wall propagation were involved. The former was accompanied by latency, suggesting that thermal activation played a significant role in the nucleation of the reversed domain. [ABSTRACT FROM AUTHOR]

Published
2020
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18. Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment

Author

Oo, May Wathone, Kawai, Hotaka, Takabatake, Kiyofumi, Tomida, Shuta, Eguchi, Takanori, Ono, Kisho, Shan, Qiusheng, Ohara, Toshiaki, Yoshida, Saori, Omori, Haruka, Sukegawa, Shintaro, Nakano, Keisuke, Okamoto, Kuniaki, Sasaki, Akira, Nagatsuka, Hitoshi, Oo, May Wathone, Kawai, Hotaka, Takabatake, Kiyofumi, Tomida, Shuta, Eguchi, Takanori, Ono, Kisho, Shan, Qiusheng, Ohara, Toshiaki, Yoshida, Saori, Omori, Haruka, Sukegawa, Shintaro, Nakano, Keisuke, Okamoto, Kuniaki, Sasaki, Akira, and Nagatsuka, Hitoshi

Abstract

Accumulating evidence has shown that cancer stroma and BM-derived cells (BMDCs) in the tumor microenvironment (TME) play vital roles in tumor progression. However, the mechanism by which oral cancer stroma recruits any particular subset of BMDCs remains largely unknown. Here, we sought to identify the subset of BMDCs that is recruited by cancer stroma. We established a sequential transplantation model in BALB/c nude mice, including (a) BM transplantation of GFP-expressing cells and (b) coxenografting of patient-derived stroma (PDS; 2 cases, designated PDS1 and PDS2) with oral cancer cells (HSC-2). As controls, xenografting was performed with HSC-2 alone or in combination with normal human dermal fibroblasts (HDF). PDS1, PDS2, and HDF all promoted BMDC migration in vitro and recruitment in vivo. Multicolor immunofluorescence revealed that the PDS coxenografts recruited Arginase-1(+)CD11b(+)GR1(+)GFP(+) cells, which are myeloid-derived suppressor cells (MDSCs), to the TME, whereas the HDF coxenograft did not. Screening using microarrays revealed that PDS1 and PDS2 expressed CCL2 mRNA (encoding C-C motif chemokine ligand 2) at higher levels than did HDF. Indeed, PDS xenografts contained significantly higher proportions of CCL2(+) stromal cells and CCR2(+)Arginase-1(+)CD11b(+)GR1(+) MDSCs (as receiver cells) than the HDF coxenograft. Consistently, a CCL2 synthesis inhibitor and a CCR2 antagonist significantly inhibited the PDS-driven migration of BM cells in vitro. Furthermore, i.p. injection of the CCR2 antagonist to the PDS xenograft models significantly reduced the CCR2(+)Arginase-1(+)CD11b(+)GR1(+) MDSC infiltration to the TME. In conclusion, oral cancer stroma-secreted CCL2 is a key signal for recruiting CCR2(+) MDSCs from BM to the TME.

Published
2022

24. Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment

Author

Oo, May Wathone, primary, Kawai, Hotaka, additional, Takabatake, Kiyofumi, additional, Tomida, Shuta, additional, Eguchi, Takanori, additional, Ono, Kisho, additional, Shan, Qiusheng, additional, Ohara, Toshiaki, additional, Yoshida, Saori, additional, Omori, Haruka, additional, Sukegawa, Shintaro, additional, Nakano, Keisuke, additional, Okamoto, Kuniaki, additional, Sasaki, Akira, additional, and Nagatsuka, Hitoshi, additional

Published
2022
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30. Enhancement of perpendicular exchange bias by introducing twin boundary in Pt/Co/α-Cr₂O₃/α-V₂O₃ epitaxial film

Author

Shiratsuchi, Yu, Yoshida, Saori, Onoue, Satoshi, Mitsumata, Chiharu, Inami, Nobuhito, Ueno, Tetsuro, Ono, Kanta, and Nakatani, Ryoichi

Subjects
Cr₂O₃, Twin, Spin frustration, Exchange anisotropy
Abstract

Y.Shiratsuchi, S.Yoshida, S.Onoue, et al. Enhancement of perpendicular exchange bias by introducing twin boundary in Pt/Co/a-Cr₂O₃/a-V₂O₃ epitaxial film. Materials Transactions 60, 2028 (2019); https://doi.org/10.2320/matertrans.MT-M2019102., Perpendicular exchange anisotropy at the Co/α-Cr₂O₃ interface was investigated using the two types of films: the film with the single crystalline α-Cr₂O₃ and that with the twinned a-Cr₂O₃. Exchange anisotropy energy density JK of the film with the single crystalline α-Cr₂O₃ was ~0.09 erg/cm² whereas JK of the film with the twinned α-Cr₂O₃ was ~0.43 erg/cm², more than 4-times enhancement. We discussed the mechanism of the enhancement of JK based on the exchange coupling at the twin boundary and that the spin frustration at the twin boundary can be the origin of the enhancement of JK.

Published
2019

37. Secretory Carcinoma of Salivary Gland with High-Grade Histology Arising in Hard Palate: A Case Report

Author

Takabatake, Kiyofumi, Nakano, Keisuke, Kawai, Hotaka, Yoshida, Saori, Omori, Haruka, Oo, May Wathone, Qiusheng, Shan, Uchida, Kenichiro, Mishima, Katsuaki, Nagatsuka, Hitoshi, Takabatake, Kiyofumi, Nakano, Keisuke, Kawai, Hotaka, Yoshida, Saori, Omori, Haruka, Oo, May Wathone, Qiusheng, Shan, Uchida, Kenichiro, Mishima, Katsuaki, and Nagatsuka, Hitoshi

Abstract

Secretory carcinoma (SC) is a recently described salivary gland tumor reported in the fourth edition of World Health Organization classification of head and neck tumors. SC is characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression, and harbors a t(12;15)(p13;q25) translocation which leads to ETV6-NTRK3 fusion product. Histologically, SC displays a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogenous or bubbly secretion. SC is generally recognized as low-grade malignancy with low-grade histopathologic features, and metastasis is relatively uncommon. In this case, we described a SC of hard palate that underwent high grade transformation and metastasis to the cervical lymph node in a 54-year-old patient. In addition, this case showed different histological findings between primary lesion and metastasis lesion. Therefore, the diagnosis was confirmed by the presence of ETV6 translocation. Here, we report a case that occurred SC with high-grade transformation in the palate, and a review of the relevant literature is also presented.

Published
2020

38. Robust magnetic domain of Pt/Co/Au/Cr₂O₃/Pt stacked films with a perpendicular exchange bias

Author

1000070379121, Shiratsuchi, Yu, Yoshida, Saori, Yoshida, Hiroaki, Kotani, Yoshinori, 1000090780007, Toyoki, Kentaro, 1000060314374, Nakatani, Ryoichi, 1000070600542, Mitsumata, Chiharu, 1000070311355, Nakamura, Tetsuya, 1000070379121, Shiratsuchi, Yu, Yoshida, Saori, Yoshida, Hiroaki, Kotani, Yoshinori, 1000090780007, Toyoki, Kentaro, 1000060314374, Nakatani, Ryoichi, 1000070600542, Mitsumata, Chiharu, 1000070311355, and Nakamura, Tetsuya

Abstract

Yu Shiratsuchi, Saori Yoshida, Hiroaki Yoshida, Yoshinori Kotani, Kentaro Toyoki, Ryoichi Nakatani, Chiharu Mitsumata, and Tetsuya Nakamura, Journal of Applied Physics 127, 153902 (2020); https://doi.org/10.1063/5.0002240., Magnetic domain pattern and magnetic domain wall motion are particularly important to understand the magnetization process. Here, we investigated the magnetization process of perpendicularly exchange-biased Pt/Co/Au/Cr₂O₃/Pt stacked films based on observations of the magnetic domain. In particular, in contrast to previous studies which use fully exchange-biased state, we used the bi-exchange-biased state. We found that the magnetic domain pattern at the remanent state was robust against magnetic-field cycling, which is relevant to the absence of the training effect. The magnetization process was followed by domain wall propagation in the increasing branch of the magnetization curve. In the decreasing branch, both nucleation of the reversed domain and domain wall propagation were involved. The former was accompanied by latency, suggesting that thermal activation played a significant role in the nucleation of the reversed domain.

Published
2020

41. The Role of Sonic Hedgehog Signaling in the Tumor Microenvironment of Oral Squamous Cell Carcinoma

Author

Takabatake, Kiyofumi, primary, Shimo, Tsuyoshi, additional, Murakami, Jun, additional, Anqi, Chang, additional, Kawai, Hotaka, additional, Yoshida, Saori, additional, Wathone Oo, May, additional, Haruka, Omori, additional, Sukegawa, Shintaro, additional, Tsujigiwa, Hidetsugu, additional, Nakano, Keisuke, additional, and Nagatsuka, Hitoshi, additional

Published
2019
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42. Differentiation and roles of bone marrow‑derived cells on the tumor microenvironment of oral squamous cell carcinoma

Author

Anqi, Chang, primary, Takabatake, Kiyofumi, additional, Kawai, Hotaka, additional, Oo, May, additional, Yoshida, Saori, additional, Fujii, Masae, additional, Omori, Haruka, additional, Sukegawa, Shintaro, additional, Nakano, Keisuke, additional, Tsujigiwa, Hidetsugu, additional, Jinhua, Zheng, additional, and Nagatsuka, Hitoshi, additional

Published
2019
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43. Morphological Analysis of Articularis Genus and Involvement in Muscle Synchronicity with Vastus Intermedius

Author

Kobayashi, Hiroto, Takano, Yuta, Yuri, Takuma, Yoshida, Saori, Suzuki, Katsuhiko, Kiyoshige, Yoshiro, and Naito, Akira

Subjects
Músculo vasto intermedio, Cadaver, Tipo de fibra muscular, Articularis genus, Músculo articular de la rodilla, Muscle fiber type, Immunohistochemistry, Cadáver, Vastus intermedius, Inmunohistoquímica
Abstract

SUMMARY: The articularis genus, which lies under the vastus intermedius, has been regarded as part of the quadriceps femoris. However, they are well known to have different function because their respective origins and insertions are mutually distinct. These muscles are considered to work almost simultaneously when the knee is extended. The electromyogram has been used to demonstrate muscle co-contraction. However, the articularis genus is deeper than other muscles. Moreover, it is difficult to analyze it by surface electromyogram. The relative proportions of muscle fiber types and the characteristics of these fiber types are important determinants of the surface electromyogram. Furthermore, biomechanical analysis of AG has remained unclear. This study investigated the ratio of muscle fiber types in these muscles. Muscle samples from seven human cadaveric specimens were used with application of immunofluorescence double staining. Results show that in the vastus intermedius and articularis genus, the percentage of Type I fibers was significantly higher than that of Type II fibers. No significant difference was found in the mean percentages of Type I and Type II fiber types. The percentages of Type I and Type II fibers in articularis genus muscle were correlated positively to the percentage in the vastus intermedius. These results suggest that similar muscle fiber compositions of these muscles might reflect their contraction during the same active phase of knee extension, despite their different functions. RESUMEN: El músculo articular de la rodilla, que se encuentra cubierto por el músculo vasto intermedio, se ha considerado como parte del músculo cuádriceps femoral. Sin embargo, es sabido que tienen diferentes funciones debido a que sus respectivos orígenes e inserciones son mutuamente distintas. Se considera que estos músculos trabajan de forma casi simultánea cuando la rodilla está extendida. El electromiograma se ha usado para demostrar la contracción muscular. Sin embargo, el músculo articular de la rodillas es más profundo que otros músculos. Además, es difícil analizarlo por electromiograma de superficie. Las proporciones relativas de los tipos de fibras musculares y las características de estos tipos de fibras son importantes determinantes del electromiograma de superficie. Además, el análisis biomecánico de músculo articular de la rodilla no ha sido claro. Este estudio investigó la proporción de tipos de fibras musculares en estos músculos. Se usaron muestras musculares de siete cadáveres humanos con la aplicación de doble tinción de inmunofluorescencia. Los resultados muestran que en los músculos articular de la rodilla y vasto intermedio, el porcentaje de fibras de Tipo I fue significativamente mayor que el de las fibras de Tipo II. No se encontraron diferencias significativas en los porcentajes medios de los Tipo I y Tipo II. Los porcentajes de fibras Tipo I y Tipo II en el músculo articular de la rodilla se correlacionaron positivamente con el porcentaje en el músculo vasto intermediario. Estos resultados sugieren que las composiciones de las fibras musculares similares de estos músculos podrían reflejar su contracción durante la misma fase activa de la extensión de la rodilla, a pesar de sus diferentes funciones.

Published
2018

45. Antitumor activity of potent pyruvate dehydrogenase kinase 4 inhibitors from plants in pancreatic cancer

Author

Tambe, Yukihiro, primary, Terado, Tokio, additional, Kim, Chul Jang, additional, Mukaisho, Ken‐ichi, additional, Yoshida, Saori, additional, Sugihara, Hiroyuki, additional, Tanaka, Hiroyuki, additional, Chida, Junji, additional, Kido, Hiroshi, additional, Yamaji, Kenzaburo, additional, Yamamoto, Tsuyoshi, additional, Nakano, Hirofumi, additional, Omura, Satoshi, additional, and Inoue, Hirokazu, additional

Published
2019
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