Search

Your search keyword '"Yoshida, Akitoshi"' showing total 786 results
Start Over Author "Yoshida, Akitoshi"
786 results on '"Yoshida, Akitoshi"'

3. A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Author

Aung, Tin, Ozaki, Mineo, Mizoguchi, Takanori, Allingham, R Rand, Li, Zheng, Haripriya, Aravind, Nakano, Satoko, Uebe, Steffen, Harder, Jeffrey M, Chan, Anita SY, Lee, Mei Chin, Burdon, Kathryn P, Astakhov, Yury S, Abu-Amero, Khaled K, Zenteno, Juan C, Nilgün, Yildirim, Zarnowski, Tomasz, Pakravan, Mohammad, Safieh, Leen Abu, Jia, Liyun, Wang, Ya Xing, Williams, Susan, Paoli, Daniela, Schlottmann, Patricio G, Huang, Lulin, Sim, Kar Seng, Foo, Jia Nee, Nakano, Masakazu, Ikeda, Yoko, Kumar, Rajesh S, Ueno, Morio, Manabe, Shin-ichi, Hayashi, Ken, Kazama, Shigeyasu, Ideta, Ryuichi, Mori, Yosai, Miyata, Kazunori, Sugiyama, Kazuhisa, Higashide, Tomomi, Chihara, Etsuo, Inoue, Kenji, Ishiko, Satoshi, Yoshida, Akitoshi, Yanagi, Masahide, Kiuchi, Yoshiaki, Aihara, Makoto, Ohashi, Tsutomu, Sakurai, Toshiya, Sugimoto, Takako, Chuman, Hideki, Matsuda, Fumihiko, Yamashiro, Kenji, Gotoh, Norimoto, Miyake, Masahiro, Astakhov, Sergei Y, Osman, Essam A, Al-Obeidan, Saleh A, Owaidhah, Ohoud, Al-Jasim, Leyla, Shahwan, Sami Al, Fogarty, Rhys A, Leo, Paul, Yetkin, Yaz, Oğuz, Çilingir, Kanavi, Mozhgan Rezaei, Beni, Afsaneh Naderi, Yazdani, Shahin, Akopov, Evgeny L, Toh, Kai-Yee, Howell, Gareth R, Orr, Andrew C, Goh, Yufen, Meah, Wee Yang, Peh, Su Qin, Kosior-Jarecka, Ewa, Lukasik, Urszula, Krumbiegel, Mandy, Vithana, Eranga N, Wong, Tien Yin, Liu, Yutao, Koch, Allison E Ashley, Challa, Pratap, Rautenbach, Robyn M, Mackey, David A, Hewitt, Alex W, Mitchell, Paul, Wang, Jie Jin, Ziskind, Ari, Carmichael, Trevor, Ramakrishnan, Rangappa, Narendran, Kalpana, Venkatesh, Rangaraj, Vijayan, Saravanan, Zhao, Peiquan, Chen, Xueyi, Guadarrama-Vallejo, Dalia, Cheng, Ching Yu, Perera, Shamira A, Husain, Rahat, and Ho, Su-Ling

Subjects
Biological Sciences, Genetics, Rare Diseases, Human Genome, Prevention, 2.1 Biological and endogenous factors, Aetiology, Animals, Asian People, Calcium Channels, Case-Control Studies, Chromosome Mapping, Exfoliation Syndrome, Genetic Predisposition to Disease, Genome-Wide Association Study, Glaucoma, Open-Angle, HEK293 Cells, HeLa Cells, Humans, Japan, MCF-7 Cells, Mice, Mice, Inbred C57BL, Polymorphism, Single Nucleotide, Tumor Cells, Cultured, Blue Mountains Eye Study GWAS Team, Wellcome Trust Case Control Consortium 2, Hela Cells, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Exfoliation syndrome (XFS) is the most common recognizable cause of open-angle glaucoma worldwide. To better understand the etiology of XFS, we conducted a genome-wide association study (GWAS) of 1,484 cases and 1,188 controls from Japan and followed up the most significant findings in a further 6,901 cases and 20,727 controls from 17 countries across 6 continents. We discovered a genome-wide significant association between a new locus (CACNA1A rs4926244) and increased susceptibility to XFS (odds ratio (OR) = 1.16, P = 3.36 × 10(-11)). Although we also confirmed overwhelming association at the LOXL1 locus, the key SNP marker (LOXL1 rs4886776) demonstrated allelic reversal depending on the ancestry group (Japanese: OR(A allele) = 9.87, P = 2.13 × 10(-217); non-Japanese: OR(A allele) = 0.49, P = 2.35 × 10(-31)). Our findings represent the first genetic locus outside of LOXL1 surpassing genome-wide significance for XFS and provide insight into the biology and pathogenesis of the disease.

Published
2015

15. Glaucoma Diagnostic Performance of Retinal Blood Flow Measurement With Doppler Optical Coherence Tomography

Author

Abe, Tsubasa, primary, Yoshioka, Takafumi, additional, Song, Youngseok, additional, Tani, Tomofumi, additional, Kawai, Motofumi, additional, Omae, Tsuneaki, additional, Takahashi, Kengo, additional, Takizawa, Yoshitaka, additional, Ro-Mase, Tomoko, additional, Ishiko, Satoshi, additional, Minamide, Kana, additional, Sakai, Jun, additional, Akiba, Masahiro, additional, Hashimoto, Yohei, additional, and Yoshida, Akitoshi, additional

Published
2022
Full Text
View/download PDF

30. A novel telerehabilitation with an educational program for caregivers using telelecture is feasible for fall prevention in elderly people

Author

Moriichi, Kentaro, primary, Fujiya, Mikihiro, additional, Ro, Takanori, additional, Ota, Tetsuo, additional, Nishimiya, Hitomi, additional, Kodama, Mariko, additional, Yoshida, Nana, additional, Hattori, Yukari, additional, Hosokawa, Tetsuya, additional, Hishiyama, Hohei, additional, Kunimoto, Masao, additional, Hayashi, Hiroki, additional, Hirokawa, Hiroyuki, additional, and Yoshida, Akitoshi, additional

Published
2022
Full Text
View/download PDF

34. Retinal Blood Velocity Waveform Characteristics With Aging and Arterial Stiffening in Hypertensive and Normotensive Subjects

Author

Takizawa, Yoshitaka, primary, Song, Youngseok, additional, Tani, Tomofumi, additional, Yoshioka, Takafumi, additional, Takahashi, Kengo, additional, Abe, Tsubasa, additional, Ro-Mase, Tomoko, additional, Ishiko, Satoshi, additional, Sakai, Jun, additional, Minamide, Kana, additional, Akiba, Masahiro, additional, Tatsukawa, Takamitsu, additional, Azuma, Nobuyoshi, additional, and Yoshida, Akitoshi, additional

Published
2021
Full Text
View/download PDF

42. Association of Rare CYP39A1 Variants with Exfoliation Syndrome Involving the Anterior Chamber of the Eye

Author

Li, Zheng, Wang, Zhenxun, Lee, Mei Chin, Zenkel, Matthias, Peh, Esther, Ozaki, Mineo, Topouzis, Fotis, Nakano, Satoko, Chan, Anita, Chen, Shuwen, Williams, Susan E.I., Orr, Andrew, Nakano, Masakazu, Kobakhidze, Nino, Zarnowski, Tomasz, Popa-Cherecheanu, Alina, Mizoguchi, Takanori, Manabe, Shin Ichi, Hayashi, Ken, Kazama, Shigeyasu, Inoue, Kenji, Mori, Yosai, Miyata, Kazunori, Sugiyama, Kazuhisa, Higashide, Tomomi, Chihara, Etsuo, Ideta, Ryuichi, Ishiko, Satoshi, Yoshida, Akitoshi, Tokumo, Kana, Kiuchi, Yoshiaki, Ohashi, Tsutomu, Sakurai, Toshiya, Sugimoto, Takako, Chuman, Hideki, Aihara, Makoto, Inatani, Masaru, Mori, Kazuhiko, Ikeda, Yoko, Ueno, Morio, Gaston, Daniel, Rafuse, Paul, Shuba, Lesya, Saunders, Joseph, Nicolela, Marcelo, Chichua, George, Tabagari, Sergo, Founti, Panayiota, Sim, Kar Seng, Meah, Wee Yang, Soo, Hui Meng, Chen, Xiao Yin, Chatzikyriakidou, Anthi, Keskini, Christina, Pappas, Theofanis, Anastasopoulos, Eleftherios, Lambropoulos, Alexandros, Panagiotou, Evangelia S., Mikropoulos, Dimitrios G., Kosior-Jarecka, Ewa, Cheong, Augustine, Li, Yuanhan, Lukasik, Urszula, Nongpiur, Monisha E., Husain, Rahat, Perera, Shamira A., Álvarez, Lydia, García, Montserrat, González-Iglesias, Héctor, Cueto, Andrés F.V., Cueto, Luis F.V., Martinón-Torres, Federico, Salas, Antonio, Oguz, Çilingir, Tamcelik, Nevbahar, Atalay, Eray, Batu, Bilge, Irkec, Murat, Aktas, Dilek, Kasim, Burcu, Astakhov, Yury S., Astakhov, Sergei Y., Akopov, Eugeny L., Giessl, Andreas, Mardin, Christian, Hellerbrand, Claus, Cooke Bailey, Jessica N., Igo, Robert P., Haines, Jonathan L., Edward, Deepak P., Heegaard, Steffen, Davila, Sonia, Tan, Patrick, Kang, Jae H., Pasquale, Louis R., Kruse, Friedrich E., Reis, André, Carmichael, Trevor R., Hauser, Michael, Ramsay, Michele, Mossböck, Georg, Yildirim, Nilgun, Tashiro, Kei, Konstas, Anastasios G.P., Coca-Prados, Miguel, Foo, Jia Nee, Kinoshita, Shigeru, Sotozono, Chie, Kubota, Toshiaki, Dubina, Michael, Ritch, Robert, Wiggs, Janey L., Pasutto, Francesca, Schlötzer-Schrehardt, Ursula, Ho, Ying Swan, Aung, Tin, Tam, Wai Leong, Khor, Chiea Chuen, Li, Zheng, Wang, Zhenxun, Lee, Mei Chin, Zenkel, Matthias, Peh, Esther, Ozaki, Mineo, Topouzis, Fotis, Nakano, Satoko, Chan, Anita, Chen, Shuwen, Williams, Susan E.I., Orr, Andrew, Nakano, Masakazu, Kobakhidze, Nino, Zarnowski, Tomasz, Popa-Cherecheanu, Alina, Mizoguchi, Takanori, Manabe, Shin Ichi, Hayashi, Ken, Kazama, Shigeyasu, Inoue, Kenji, Mori, Yosai, Miyata, Kazunori, Sugiyama, Kazuhisa, Higashide, Tomomi, Chihara, Etsuo, Ideta, Ryuichi, Ishiko, Satoshi, Yoshida, Akitoshi, Tokumo, Kana, Kiuchi, Yoshiaki, Ohashi, Tsutomu, Sakurai, Toshiya, Sugimoto, Takako, Chuman, Hideki, Aihara, Makoto, Inatani, Masaru, Mori, Kazuhiko, Ikeda, Yoko, Ueno, Morio, Gaston, Daniel, Rafuse, Paul, Shuba, Lesya, Saunders, Joseph, Nicolela, Marcelo, Chichua, George, Tabagari, Sergo, Founti, Panayiota, Sim, Kar Seng, Meah, Wee Yang, Soo, Hui Meng, Chen, Xiao Yin, Chatzikyriakidou, Anthi, Keskini, Christina, Pappas, Theofanis, Anastasopoulos, Eleftherios, Lambropoulos, Alexandros, Panagiotou, Evangelia S., Mikropoulos, Dimitrios G., Kosior-Jarecka, Ewa, Cheong, Augustine, Li, Yuanhan, Lukasik, Urszula, Nongpiur, Monisha E., Husain, Rahat, Perera, Shamira A., Álvarez, Lydia, García, Montserrat, González-Iglesias, Héctor, Cueto, Andrés F.V., Cueto, Luis F.V., Martinón-Torres, Federico, Salas, Antonio, Oguz, Çilingir, Tamcelik, Nevbahar, Atalay, Eray, Batu, Bilge, Irkec, Murat, Aktas, Dilek, Kasim, Burcu, Astakhov, Yury S., Astakhov, Sergei Y., Akopov, Eugeny L., Giessl, Andreas, Mardin, Christian, Hellerbrand, Claus, Cooke Bailey, Jessica N., Igo, Robert P., Haines, Jonathan L., Edward, Deepak P., Heegaard, Steffen, Davila, Sonia, Tan, Patrick, Kang, Jae H., Pasquale, Louis R., Kruse, Friedrich E., Reis, André, Carmichael, Trevor R., Hauser, Michael, Ramsay, Michele, Mossböck, Georg, Yildirim, Nilgun, Tashiro, Kei, Konstas, Anastasios G.P., Coca-Prados, Miguel, Foo, Jia Nee, Kinoshita, Shigeru, Sotozono, Chie, Kubota, Toshiaki, Dubina, Michael, Ritch, Robert, Wiggs, Janey L., Pasutto, Francesca, Schlötzer-Schrehardt, Ursula, Ho, Ying Swan, Aung, Tin, Tam, Wai Leong, and Khor, Chiea Chuen

Abstract

Importance: Exfoliation syndrome is a systemic disorder characterized by progressive accumulation of abnormal fibrillar protein aggregates manifesting clinically in the anterior chamber of the eye. This disorder is the most commonly known cause of glaucoma and a major cause of irreversible blindness. Objective: To determine if exfoliation syndrome is associated with rare, protein-changing variants predicted to impair protein function. Design, Setting, and Participants: A 2-stage, case-control, whole-exome sequencing association study with a discovery cohort and 2 independently ascertained validation cohorts. Study participants from 14 countries were enrolled between February 1999 and December 2019. The date of last clinical follow-up was December 2019. Affected individuals had exfoliation material on anterior segment structures of at least 1 eye as visualized by slit lamp examination. Unaffected individuals had no signs of exfoliation syndrome. Exposures: Rare, coding-sequence genetic variants predicted to be damaging by bioinformatic algorithms trained to recognize alterations that impair protein function. Main Outcomes and Measures: The primary outcome was the presence of exfoliation syndrome. Exome-wide significance for detected variants was defined as P < 2.5 × 10-6. The secondary outcomes included biochemical enzymatic assays and gene expression analyses. Results: The discovery cohort included 4028 participants with exfoliation syndrome (median age, 78 years [interquartile range, 73-83 years]; 2377 [59.0%] women) and 5638 participants without exfoliation syndrome (median age, 72 years [interquartile range, 65-78 years]; 3159 [56.0%] women). In the discovery cohort, persons with exfoliation syndrome, compared with those without exfoliation syndrome, were significantly more likely to carry damaging CYP39A1 variants (1.3% vs 0.30%, respectively; odds ratio, 3.55 [95% CI, 2.07-6.10]; P = 6.1 × 10-7). This outcome was validated in 2 independent cohorts. The fi

Published
2021

43. Retinal Nonperfusion Relationship to Arteries or Veins Observed on Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy

Author

Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Research Laboratory of Electronics, Ishibazawa, Akihiro, De Pretto, Lucas R., Alibhai, A. Yasin, Moult, Eric M., Arya, Malvika, Sorour, Osama, Mehta, Nihaal, Baumal, Caroline R., Witkin, Andre J., Yoshida, Akitoshi, Duker, Jay S., Fujimoto, James G., Waheed, Nadia K., Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Research Laboratory of Electronics, Ishibazawa, Akihiro, De Pretto, Lucas R., Alibhai, A. Yasin, Moult, Eric M., Arya, Malvika, Sorour, Osama, Mehta, Nihaal, Baumal, Caroline R., Witkin, Andre J., Yoshida, Akitoshi, Duker, Jay S., Fujimoto, James G., and Waheed, Nadia K.

Abstract

Copyright 2019 The Authors PURPOSE. To evaluate whether retinal capillary nonperfusion is found predominantly adjacent to arteries or veins in eyes with diabetic retinopathy (DR). METHODS. Sixty-three eyes from 44 patients with proliferative DR (PDR) or non-PDR (NPDR) were included. Images (12 3 12-mm) foveal-centered optical coherence tomography (OCT) angiography (OCTA) images were taken using the Zeiss Plex Elite 9000. In 37 eyes, widefield montages with five fixation points were also obtained. A semiautomatic algorithm that detects nonperfusion in full-retina OCT slabs was developed, and the percentages of capillary nonperfusion within the total image area were calculated. Retinal arteries and veins were manually traced. Based on the shortest distance, nonperfusion pixels were labeled as either arterial-side or venous-side. Arterial-adjacent and venous-adjacent nonperfusion and the A/V ratio (arterial-adjacent nonperfusion divided by venous-adjacent nonperfusion) were quantified. RESULTS. Twenty-two eyes with moderate NPDR, 16 eyes with severe NPDR, and 25 eyes with PDR were scanned. Total nonperfusion area in PDR (median: 8.93%) was greater than in moderate NPDR (3.49%, P < 0.01). Arterial-adjacent nonperfusion was greater than venous-adjacent nonperfusion for all stages of DR (P < 0.001). The median A/V ratios were 1.93 in moderate NPDR, 1.84 in severe NPDR, and 1.78 in PDR. The A/V ratio was negatively correlated with the total nonperfusion area (r ¼ -0.600, P < 0.0001). The results from the widefield montages showed similar patterns. CONCLUSIONS. OCTA images with arteries and veins traced allowed us to estimate the nonperfusion distribution. In DR, smaller nonperfusion tends to be arterial-adjacent, while larger nonperfusion tends toward veins.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results