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31 results on '"Yoon, Yoonsun"'

5. Childcare Exposure to Severe Acute Respiratory Syndrome Coronavirus 2 for 4-Year-Old Presymptomatic Child, South Korea

Author

Yoon, Yoonsun, Choi, Gwang-Jun, Kim, Ji Yeong, Kim, Kyung-Ran, Park, Hwanhee, Chun, Jae Kyung, and Kim, Yae-Jean

Subjects
Children -- Diseases, Health
Abstract

The exact number of global confirmed cases of coronavirus disease (COVID-19) in children is unknown. Since the first case report in a child, 2.2%-6.7% of reported cases from China, the [...]

Published
2021
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11. Malignancy in Patients With Inborn Errors of Immunity Beyond Infectious Complication: Single Center Experience for 30 Years

Author

Kim, Doo Ri, primary, Kim, Kyung-Ran, additional, Park, Hwanhee, additional, Choi, Joon-sik, additional, Yoon, Yoonsun, additional, Son, Sohee, additional, Ju, Hee Young, additional, Kim, Jihyun, additional, Yoo, Keon Hee, additional, Ahn, Kangmo, additional, Kim, Hee-Jin, additional, Kang, Eun-Suk, additional, Cho, Junhun, additional, Park, Su Eun, additional, Kim, Kihyun, additional, and Kim, Yae-Jean, additional

Published
2023
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12. SARS-CoV-2 mRNA Vaccine Elicits Sustained T Cell Responses Against the Omicron Variant in Adolescents

Author

Choi, Sujin, primary, Kim, Sang-Hoon, additional, Han, Mi Seon, additional, Yoon, Yoonsun, additional, Kim, Yun-Kyung, additional, Cho, Hye-Kyung, additional, Yun, Ki Wook, additional, Song, Seung Ha, additional, Ahn, Bin, additional, Kim, Ye Kyung, additional, Choi, Sung Hwan, additional, Choe, Young June, additional, Lim, Heeji, additional, Choi, Eun Bee, additional, Kim, Kwangwook, additional, Hyeon, Seokhwan, additional, Lim, Hye Jung, additional, Kim, Byung-chul, additional, Lee, Yoo-kyoung, additional, Choi, Eun Hwa, additional, Shin, Eui-Cheol, additional, and Lee, Hyunju, additional

Published
2023
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13. Global varicella vaccination programs

Author

Lee, Young Hwa, primary, Choe, Young June, additional, Lee, Jia, additional, Kim, Eunseong, additional, Lee, Jae Young, additional, Hong, Kwan, additional, Yoon, Yoonsun, additional, and Kim, Yun-Kyung, additional

Published
2022
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30. The Impact of an Antimicrobial Stewardship Program on Days of Therapy in the Pediatric Center: An Interrupted Time-Series Analysis of a 19-Year Study.

Author

Kim KR, Park HJ, Baek SY, Choi SH, Lee BK, Kim S, Kim JM, Kang JM, Kim SJ, Choi SR, Kim D, Choi JS, Yoon Y, Park H, Kim DR, Shin A, Kim S, and Kim YJ

Subjects
Humans, Retrospective Studies, Child, Female, Male, Child, Preschool, Infant, Adolescent, Escherichia coli drug effects, Escherichia coli isolation & purification, Hospitals, Pediatric, Antimicrobial Stewardship, Bacteremia drug therapy, Bacteremia mortality, Bacteremia microbiology, Interrupted Time Series Analysis, Anti-Bacterial Agents therapeutic use, Klebsiella pneumoniae drug effects, Klebsiella pneumoniae isolation & purification
Abstract

Background: We aimed to analyze the effects of an antimicrobial stewardship program (ASP) on the proportion of antimicrobial-resistant pathogens in bacteremia, antimicrobial use, and mortality in pediatric patients., Methods: A retrospective single-center study was performed on pediatric inpatients under 19 years old who received systemic antimicrobial treatment from 2001 to 2019. A pediatric infectious disease attending physician started ASP in January 2008. The study period was divided into the pre-intervention (2001-2008) and the post-intervention (2009-2019) periods. The amount of antimicrobial use was defined as days of therapy per 1,000 patient-days, and the differences were compared using delta slope (= changes in slopes) between the two study periods by an interrupted time-series analysis. The proportion of resistant pathogens and the 30-day overall mortality rate were analyzed by the χ²., Results: The proportion of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae bacteremia increased from 17% (39 of 235) in the pre-intervention period to 35% (189 of 533) in the post-intervention period ( P < 0.001). The total amount of antimicrobial use significantly decreased after the introduction of ASP (delta slope value = -16.5; 95% confidence interval [CI], -30.6 to -2.3; P = 0.049). The 30-day overall mortality rate in patients with bacteremia did not increase, being 10% (55 of 564) in the pre-intervention and 10% (94 of 941) in the post-intervention period ( P = 0.881)., Conclusion: The introduction of ASP for pediatric patients reduced the delta slope of the total antimicrobial use without increasing the mortality rate despite an increased incidence of ESBL-producing gram-negative bacteremia., Competing Interests: The authors have no potential conflicts of interest to declare., (© 2024 The Korean Academy of Medical Sciences.)

Published
2024
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31. Elevated fecal calprotectin levels are associated with severity of atopic dermatitis in children.

Author

Seo SC, Ahn SH, Ri S, Yoon Y, Byeon JH, Kim SH, Yoon W, and Yoo Y

Subjects
Adolescent, Biomarkers analysis, Child, Child, Preschool, Feces, Female, Gastrointestinal Microbiome immunology, Humans, Inflammation immunology, Leukocyte L1 Antigen Complex metabolism, Male, Dermatitis, Atopic immunology, Leukocyte L1 Antigen Complex analysis
Abstract

Background: Recent data suggested that imbalance in gut microbiota and gastrointestinal inflammation are associated with the childhood allergic disease. Fecal calprotectin has been used for a non-invasive marker of gut inflammation., Objective: The aim of this study was to investigate the relationships between fecal calprotectin level and the clinical severity of atopic dermatitis (AD) in children., Methods: We enrolled 65 subjects with AD. The concentration of calprotectin was measured in each subject's fecal sample., Results: The geometric mean fecal calprotectin level of the total subjects was 33.1(10.1-108.9) μg/g. Among the 65 subjects, 44(67.7%) showed calprotectin levels lower than 50μg/g(Group 1), and 21(32.3%) were higher than 50μg/g(Group 2). The mean SCORAD index was significantly higher in Group 2 than Group 1(31.0±16.0 vs 22.2±15.3, p=0.046). The geometric mean serum total IgE levels was higher in Group 2 compared to Group 1(361.4[31.6-992.3]IU/mL vs 175.9[44.3-699.2]IU/mL, p=0.040). The mean blood eosinophils were significantly higher in Group 2 than in Group 1(497.7[239.8-1032.8]/μL vs 281.5[121.5-652.0]/μL, p=0.034). The incidence of exposure to environmental tobacco smoke was significantly higher in Group 2 compared to Group 1(76.2% vs 47.7%, p=0.036). Geometric mean fecal calprotectin level in severe AD was significantly higher than that of mild-to-moderate AD(66.7[13.5-330.3]μg/g vs 29.4[10.1-85.6]μg/g, p=0.044). The fecal calprotectin level significantly correlated with the SCORAD index(r=0.303, p=0.014)., Conclusions: Higher fecal calprotectin levels were observed in subjects with severe AD. Elevated fecal calprotectin level as a gastrointestinal inflammatory marker may associate with childhood AD. Measurement of fecal calprotectin might be useful for assessment of severity of childhood AD.

Published
2018
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