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The purpose of the current research is to synthesize radiolabeled rutin for biodistribution study and SPECT/CT image of rutin. The optimized radiolabeling condition provided I-labeled rutin with 53.5 % of radiochemical yield. Most of orally administered I-labeled rutin was initially found in the stomach and small intestine and a portion of the product was then distributed in internal organs. While intravenously injected I-labeled rutin was accumulated in liver and then a large part of it was transferred to small intestine. The present results provided an efficient radiolabeling method of flavonoid glycoside as well as quantitative organ distribution of rutin. [ABSTRACT FROM AUTHOR]

The aim of this study is to synthesize I-labeled 2-(4-iodophenethyl)-2-methylmalonic acid ([I]IMA) for the development of new apoptosis imaging tracer. The optimized radiolabeling procedure provided [I]IMA with high radiochemical yield (75.5 ± 5.2 %) and radiochemical purity (>99 %) within 100 min. Specific radioactivity of [I]IMA was 31.0 MBq/μmol. Biodistribution study of [I]IMA was carried out using ICR mouse and the result showed the uptake values in apoptotic cells of the testes of the male mice were 1.7-3.2 fold higher than those of leg muscle. Therefore, [I]IMA will be a promising radiotracer for in vivo SPECT imaging of apoptotic cells. [ABSTRACT FROM AUTHOR]

The purpose of this study is to synthesize I-labeled hesperetin and to investigate its in vivo behavior. The optimized labeling condition provided two isomers of I-labeled hesperetin with high radiochemical yields and radiochemical purities. Both I-labeled products were orally administered to normal ICR mice, and the initial result showed that most of I activity was detected in the stomach and the intestines. A part of I-labeled hesperetin was absorbed from the small intestine to bloodstream and then it was distributed in normal organs. The results in the present study provided an efficient radiolabeling method of flavonoid and quantitative organ distribution of orally administered hesperetin. [ABSTRACT FROM AUTHOR]