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459 results on '"Yoon, Jin-Young"'

10. The Relationship of Fish Functional Traits, Physicochemical Characteristics and Exotic Fish (Micropterus salmoides and Lepomis macrochirus).

Author

Bold, Misheel, Kim, Kyu-Jin, Yoon, Jin-Young, Kim, Mooseong, Yoon, Juduk, Kim, Jae-Goo, Kim, Keonhee, and Jang, Min-Ho

Subjects
NATIVE species, BIOLOGICAL extinction, FISH diversity, INTRODUCED species, NATURAL resources, WATERSHEDS
Abstract

An invasive species is defined as a biological species introduced, most often through human action, that causes direct harm, such as reducing or driving native species to extinction. This introduction can result in long-term changes to ecosystem structures and ultimately contribute to a decline in biodiversity within areas where it was not previously present. Thus, continuous monitoring and management are essential. This study examined the impact of two exotic species, largemouth bass (Micropterus salmoides) and bluegill (Lepomis macrochirus), on fish diversity in rivers across South Korea. Data from the "Stream Ecosystem Survey and Health Assessment" project, which was conducted along five major river basins between 2013 and 2021, were analyzed. The data were divided into three periods: 2013–2015, 2016–2018, and 2019–2021, covering a total of 960 sites. The results revealed that largemouth bass and bluegill were present at 360 sites (37.5%) from 2013 to 2015, 325 sites (33.9%) from 2016 to 2018, and 356 sites (37.1%) from 2019 to 2021. Additionally, when comparing sites where exotic fish were present with those where they were absent, the average number of native species was slightly higher in areas where these invasive species were present, yet the average Fish Assessment Index (FAI) value was lower. Statistically significant differences were observed in fish diversity, especially in trophic and tolerance traits. This study provides valuable insight into the impact of invasive species on South Korean river ecosystems and offers important information for developing future conservation and management strategies for biological resources. [ABSTRACT FROM AUTHOR]

Published
2024
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31. A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality

Author

Zhang, Xiaoming, Yoon, Jin-Young, Morley, Michael, McLendon, Jared M., Mapuskar, Kranti A., Gutmann, Rebecca, Mehdi, Haider, Bloom, Heather L., Dudley, Samuel C., Ellinor, Patrick T., Shalaby, Alaa A., Weiss, Raul, Tang, W.H. Wilson, Moravec, Christine S., Singh, Madhurmeet, Taylor, Anne L., Yancy, Clyde W., Feldman, Arthur M., McNamara, Dennis M., Irani, Kaikobad, Spitz, Douglas R., Breheny, Patrick, Margulies, Kenneth B., London, Barry, and Boudreau, Ryan L.

Subjects
Sodium channels -- Health aspects, MicroRNA -- Health aspects, Heart diseases -- Genetic aspects -- Development and progression -- Care and treatment, Genetic variation -- Health aspects, Health care industry
Abstract

SCN5A encodes the voltage-gated [Na.sup.+] channel [Na.sub.v]1.5 that is responsible for depolarization of the cardiac action potential and rapid intercellular conduction. Mutations disrupting the SCN5A coding sequence cause inherited arrhythmias and cardiomyopathy, and single-nucleotide polymorphisms (SNPs) linked to SCN5A splicing, localization, and function associate with heart failure-related sudden cardiac death. However, the clinical relevance of SNPs that modulate SCN5A expression levels remains understudied. We recently generated a transcriptome-wide map of microRNA (miR) binding sites in human heart, evaluated their overlap with common SNPs, and identified a synonymous SNP (rs1805126) adjacent to a miR-24 site within the SCN5A coding sequence. This SNP was previously shown to reproducibly associate with cardiac electrophysiological parameters, but was not considered to be causal. Here, we show that miR-24 potently suppresses SCN5A expression and that rs1805126 modulates this regulation. We found that the rs1805126 minor allele associates with decreased cardiac SCN5A expression and that heart failure subjects homozygous for the minor allele have decreased ejection fraction and increased mortality, but not increased ventricular tachyarrhythmias. In mice, we identified a potential basis for this in discovering that decreased 5cn5a expression leads to accumulation of myocardial reactive oxygen species. Together, these data reiterate the importance of considering the mechanistic significance of synonymous SNPs as they relate to miRs and disease, and highlight a surprising link between SCN5A expression and nonarrhythmic death in heart failure., Introduction The onset and clinical course of heart failure is shaped by a complex interplay of environmental and genetic factors that influence a host of biological processes, including gene regulatory [...]

Published
2018
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40. Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel

Author

Vikram, Ajit, Lewarchik, Christopher M, Yoon, Jin-Young, Naqvi, Asma, Kumar, Santosh, Morgan, Gina M, Jacobs, Julia S, Li, Qiuxia, Kim, Young-Rae, Kassan, Modar, Liu, Jing, Gabani, Mohanad, Kumar, Ajay, Mehdi, Haider, Zhu, Xiaodong, Guan, Xiaoqun, Kutschke, William, Zhang, Xiaoming, Boudreau, Ryan L, Dai, Shengchuan, Matasic, Daniel S, Jung, Saet-Byel, Margulies, Kenneth B, Kumar, Vikas, Bachschmid, Markus M, London, Barry, and Irani, Kaikobad

Subjects
Sodium channels -- Health aspects, Electrophysiology -- Genetic aspects, Myocardium -- Genetic aspects, Gene mutation -- Health aspects, Signaling peptides and proteins -- Health aspects, Biological sciences, Health
Abstract

Author(s): Ajit Vikram [1]; Christopher M Lewarchik [2]; Jin-Young Yoon [1]; Asma Naqvi [2]; Santosh Kumar [1]; Gina M Morgan [1]; Julia S Jacobs [1]; Qiuxia Li [1]; Young-Rae Kim [...]

Published
2017
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