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2 results on '"Yoo Kyung Annie Lee"'

1. NK cell-based cancer immunotherapy: from basic biology to clinical development

Author

Sizhe Liu, Vasiliy Galat, Yekaterina Galat, Yoo Kyung Annie Lee, Derek Wainwright, and Jennifer Wu

Subjects
NK cell, Cancer immunotherapy, Clinical trials, iPSC, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in immune activation against abnormal cells. Different from events required for T cell activation, NK cell activation is governed by the interaction of NK receptors with target cells, independent of antigen processing and presentation. Due to relatively unsophisticated cues for activation, NK cell has gained significant attention in the field of cancer immunotherapy. Many efforts are emerging for developing and engineering NK cell-based cancer immunotherapy. In this review, we provide our current understandings of NK cell biology, ongoing pre-clinical and clinical development of NK cell-based therapies and discuss the progress, challenges, and future perspectives.

Published
2021
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2. NK cell-based cancer immunotherapy: from basic biology to clinical development

Author

Sizhe Liu, Yoo Kyung Annie Lee, Derek A. Wainwright, Vasiliy Galat, Jennifer D. Wu, and Yekaterina Galat

Subjects
Cancer Research, medicine.medical_specialty, NK cell activation, medicine.medical_treatment, T cell, Cell, Cancer immunotherapy, Review, Biology, Lymphocyte Activation, lcsh:RC254-282, Immunotherapy, Adoptive, Clinical trials, Internal medicine, Neoplasms, medicine, Animals, Humans, NK cell, Receptor, Molecular Biology, Immunologic Surveillance, Clinical Trials as Topic, Hematology, iPSC, Antigen processing, lcsh:RC633-647.5, lcsh:Diseases of the blood and blood-forming organs, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Killer Cells, Natural, medicine.anatomical_structure, Oncology, Cancer research, Tumor Escape, Cell based
Abstract

Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in immune activation against abnormal cells. Different from events required for T cell activation, NK cell activation is governed by the interaction of NK receptors with target cells, independent of antigen processing and presentation. Due to relatively unsophisticated cues for activation, NK cell has gained significant attention in the field of cancer immunotherapy. Many efforts are emerging for developing and engineering NK cell-based cancer immunotherapy. In this review, we provide our current understandings of NK cell biology, ongoing pre-clinical and clinical development of NK cell-based therapies and discuss the progress, challenges, and future perspectives.

Published
2020

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