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Objective To evaluate the association between balance function and asymmetry of knee extension strength in an elderly Korean population. Methods The strength of the knee extensors in each leg was measured in 306 community-dwelling elderly subjects (age, 76.70±4.85 years) and 25 young healthy subjects (age, 34.23±8.93 years). Based on the difference in strength of both legs, the elderly subjects were divided into symmetric (n=128) and asymmetric (n=178) strength groups using an asymmetry cutoff 20%. We determined the postural control ability of the subjects using InBody posturography, Berg Balance Scale (BBS), Timed Up and Go test (TUG) and Short Physical Performance Battery (SPPB). The sway index (SI) of the subjects in four positions was assessed using posturography. Results The group with asymmetric strength presented a significantly higher SI than the group with symmetric strength, in the normal position with eyes open and eyes open on pillows. In the normal position with the eyes closed and in postures with the eyes closed on pillows, the statistical analysis revealed no significant differences between the two groups. The three tests for physical performance (BBS, TUG, and SPPB) show no statistically significant difference between the two groups. Conclusion The asymmetric strength group showed a significantly lower balance than the group with symmetric strength based on several posturographic parameters. Ambulatory elderly individuals with asymmetry in knee extension strength, showed deficits in balance control even in normal clinical tests.

Objective To investigate the differences in biomechanical parameters measured by gait analysis systems between healthy subjects and subjects with plantar fasciitis (PF), and to compare biomechanical parameters between 'normal, barefooted' gait and arch building gait in the participants. Methods The researchers evaluated 15 subjects (30 feet) with bilateral foot pain and 15 subjects (15 feet) with unilateral foot pain who had a clinical diagnosis of PF. Additionally, 17 subjects (34 feet) who had no heel pain were recruited. Subjects were excluded if they had a traumatic event, prior surgery or fractures of the lower limbs, a leg length discrepancy of 1 cm or greater, a body mass index greater than 35 kg/m2, or had musculoskeletal disorders. The participants were asked to walk with an arch building gait on a treadmill at 2.3 km/hr for 5 minutes. Various gait parameters were measured. Results With the arch building gait, the PF group proved that gait line length and single support line were significantly decreased, and lateral symmetry of the PF group was increased compared to that of the control group. The subjects with bilateral PF displayed significantly increased maximum pressure over the heel and the forefoot during arch building gait. In addition, the subjects with unilateral PF showed significantly increased maximum pressure over the forefoot with arch building gait. Conclusion The researchers show that various biomechanical differences exist between healthy subjects and those with PF. Employing an arch building gait in patients with PF could be helpful in changing gait patterns to normal biomechanics.

In this research, we aim to analyze the trend of Huawei's PCT patent applications. As a result of analyzing Huawei's PCT patents by dividing temporal spans into three periods - the early 2000s, the late 2000s, and the early 2010s -, the following characteristics have been observed. First, the number of PCT patent applications has conspicuously increased from the early 2000s to the late 2000s and this trend has continued during the early 2010s. Second, in terms of a core technological field, whereas Huawei focused on the development of technologies in the 'H04L: transmission of digital information' sector during the early/late 2000s, it changed this field to the 'H04W: wireless communication networks' sector during the early 2010s. Lastly, in the case of the patent maps, it was found that while general communications technologies, as expressed with such keywords as 'user' and 'network,' were actively developed during the early/late 2000s, mobile phone-related technologies grasped this leading position, as shown with the keywords including 'user equipment,' 'base station,' and 'MME,' during the early 2010s. It was also noticeable that Huawei filed LTE-related patent applications more actively than Apple and Samsung Electronics, which implies that it will presumably pioneer the global market more aggressively than its competitors in the future.

This study aims to analyse the essential patent portfolios of individual firms via bibliometric mapping. Based on the maps drawn via this method, important clusters of each company are analysed and two interpretations are made. As an illustration, the mobile phone industry is selected because standardisation is highly important for firms in this industry. Among others, long-term evolution (LTE) of the 4G era is chosen as a standard and Qualcomm, Nokia, Ericsson, and NTT DOCOMO are included as leading firms. As a result, firm-wise LTE essential patent portfolios were visualised. Based on the information given in these maps, two important clusters (i.e. the clusters composed of frequently emerging words and their periphery and the clusters including particularly noticeable terms) were analysed. In addition, two interpretations were made as follows. First, specialised and expandable technological clusters for each company (14 specialised/expandable clusters for Qualcomm, 8 for Nokia, 11 for Ericsson, and 10 ...

Guillain-Barre syndrome (GBS) and syringomyelia are diseases of different entities. GBS is an acute post-infectious autoimmune disease which is mediated by autoantibodies against the myelin of peripheral nerves. Syringomyelia is a chronic disease characterized by a cavity extending longitudinally inside the spinal cord. A 67-year-old man is being hospitalized due to severe numbness and ascending weakness in all limbs. On neurological examination, the motor power of all limbs are decreased and show absence of deep tendon reflexes (DTRs). The patient is being diagnosed with GBS on the basis of the acute clinical course, nerve conduction studies of segmental demyelinating polyneuropathy, and a finding of albuminocytologic dissociation in the cerebrospinal fluid. The patient is presented with a new set of symptoms thereafter, which composes of sensory changes in the upper extremities, the urinary dysfunction including frequency and residual urine, spastic bilateral lower extremities, and increased reflexes of the knee and the biceps at follow-up examinations. The spinal magnetic resonance imaging in the sagittal section revealed a syrinx cavity between the fifth cervical and the first thoracic vertebral segment in the cord. The somatosensory evoked potential show sensory pathway defects between both the brachial plexus and the brain stem. Thus, this patient is being diagnosed with both GBS and syringomyelia. We report a case of symptomatic syringomyelia coexisting with GBS. Since the GBS is presented with a progressive muscle weakness and reduced DTRs, the muscle weakness and stiffness in the extremities suggests a concurrent syringomyelia might be easily overlooked.

Degenerative lumbar scoliosis (DLS) progresses with aging after 50–60 years. The genetic association of DLS remains largely unclear. In this study, the genetic association between glutamate receptor, ionotropic, N-methyl D-aspartate (NMDA, GRIN) receptor genes and DLS was investigated. A total of 9 coding single nucleotide polymorphisms (cSNPs) in NMDA receptor genes [GRIN2A (rs8049651, Leu425Leu; rs9806806, Tyr730Tyr); GRIN2B (rs7301328, Pro122Pro; rs35025065, Asp447Asp; rs1805522, Ile602Ile; rs1806201, Thr888Thr; rs1805247, His1399His); and GRIN2C (rs689730, Ala33Ala; rs3744215, Arg1209Ser)] were selected and genotyped using direct sequencing in 70 patients with DLS and 141 healthy controls. Multiple logistic models (codominant, dominant and recessive) were calculated for the odds ratio (OR), 95% confidence interval (CI) and corresponding P-values. The SNPStats, SNPAnalyzer and HelixTree programs were used for the evaluation of the genetic data. Among the SNPs examined, no significant associations were observed between the NMDA receptor genes and DLS. When the patients were divided into two groups according to clinical characteristics based on Cobb’s angle (

Objective To assess the cross-sectional area (CSA) of the muscles for investigating the occurrence of asymmetry of the paraspinal (multifidus and erector spinae) and psoas muscles and its relation to the chronicity of unilateral lumbar radiculopathy using magnetic resonance imaging (MRI). Methods This retrospective study was conducted between January 2012 to December 2014. Sixty one patients with unilateral L5 radiculopathy were enrolled: 30 patients had a symptom duration less than 3 months (group A) and 31 patients had a symptom duration of 3 months or more (group B). Axial MRI measured the CSA of the paraspinal and psoas muscles at the middle between the lower margin of the upper vertebra and upper margin of the lower vertebra, and obtained the relative CSA (rCSA) which is the ratio of the CSA of muscles to that of the lower margin of L4 vertebra. Results There were no differences in the demographics between the two groups. In group B, rCSA of the erector spinae at the L4-5 level, and that of multifidus at the L4-5 and L5-S1 levels, were significantly smaller on the involved side as compared with the uninvolved side. In contrast, no significant muscle asymmetry was observed in group A. The rCSA of the psoas was not affected in either group. Conclusion The atrophy of the multifidus and erector spinae ipsilateral to the lumbar radiculopathy was observed only in patients suffering from unilateral radiculopathy for 3 months or more.

In many countries, the selection of appropriate RD at the product level, we propose the existence of a subject and its competence; and at the technological level, we propose the possibility of technological realization, technological attractiveness and...

In this study, we estimate the input–output relationship between R&D investment and the number of patents granted to Korean firms by the US Patent and Trademark Office and the Korean Intellectual Property Office. Using pooled panel data and time-series data, we also examine the influence of the characteristics of the firms, viz. their export-orientation, the degree of foreign ownership and Chaebol-affiliation on the input–output relationship. It was found that the elasticities of US and Korean patents for R&D investment are 1.56 and 1.38, respectively. It was also shown that, in general, export-oriented firms, firms with higher foreign ownership and non-Chaebol firms have higher patent producing capability.

In recent years, as the development of science and technology rapidly accelerated, science- and technology-based industries have emerged. Representative examples are the Information and Telecommunications (IT) industry in the late 20th century and more recently the BioTechnology (BT) and NanoTechnology (NT) industries. However, despite the emergence of science- and technology- based industries, industrial policy-makers have suffered difficulties in grasping exactly what kinds of science and technology they should manage. Therefore, in this research, I propose a method of linking science and technology with industry, by adopting the media wherethrough they are delivered. As the media for conveying science and technology, I make use of the scientific articles administered by the Institute of Scientific Information (ISI) and the patents registered in the US Patent Office (USPTO). In this way, I identified 750 journals and 84 US patent classes corresponding to the IT industry, 1779 journals and 7 patent classes corresponding to the BT industry and 483 journals and 16 patent classes corresponding to the NT industry. This research is meaningful in that it emphasized the importance and convenience of scientific articles and patents in formulating today’s industrial policies and showed how to link science and technology with industry, by using the subject categories of the ISI and the patent classes of the USPTO.

Under the National Innovation System (NIS) framework, knowledge stock has been recognized as a key factor for enhancing national innovative capabilities. However, despite the importance of patents and papers for measuring knowledge, previous research has not fully utilized patent and paper databases, and has instead relied on research and development (R&D) data. Therefore, in this research, I introduce a way to utilize both types of useful data when measuring industrial knowledge stocks. As primary data sources, the United States Patent and Trademark Office (USPTO) Web site for patents and the science citation index (SCI) for papers are used. In the case of Korea, the amount of knowledge stock proxied by patents and papers is different from that proxied by R&D, which indicates in turn that using a single indicator such as R&D may be misleading. Although the result may vary depending on the selected nation, the proposed method will be useful for gauging knowledge stocks in a more complementary way.

Objective To evaluate the relationships between tongue pressure and different aspects of the oral-phase swallowing function. Methods We included 96 stroke patients with dysphagia, ranging in age from 40 to 88 years (mean, 63.7 years). Measurements of tongue pressure were obtained with the Iowa Oral Performance Instrument, a device with established normative data. Three trials of maximum performance were performed for lip closure pressure (LP), anterior hard palate-to-tongue pressure (AP), and posterior hard palate-to-tongue pressure (PP); buccal-to-tongue pressures on both sides were also recorded (buccal-to-tongue pressure, on the weak side [BW]; buccal-to-tongue pressure, on the healthy side [BH]). The average pressure in each result was compared between the groups. Clinical evaluation of the swallowing function was performed with a videofluoroscopic swallowing study. Results The average maximum AP and PP values in the intact LC group were significantly higher than those in the inadequate lip closure group (AP, p=0.003; PP, p

Based on the notion of the national innovation system (NIS), this paper proposes an exploratory method of measuring inter-industrial knowledge flows. The proposed measures are based on patent analysis and input–output analysis. By employing the Korean case, the knowledge measures are gauged and the knowledge network is visualized. For both disembodied and embodied knowledge, the densities of the knowledge network have steadily increased over time and the knowledge linkage between the traditional sector and the emerging sector has become more active, along with the evolutionary advancement of industrial structure. However, the knowledge network is still incomplete in that some weak ties and missing links exist. Although the Korean case may not be generally applicable due to national idiosyncrasies, the proposed framework provides a useful tool for measuring knowledge stock and flows at sectoral or industrial level.

The purpose of this study was to investigate single nucleotide polymorphisms (SNPs) of the BH3 interacting domain death agonist (BID) gene as a risk factor in Korean patients with ossification of the posterior longitudinal ligament (OPLL). To investigate the genetic association, two coding SNPs (rs8190315, Ser10Gly; rs2072392, Asp60Asp) of BID were genotyped in 157 OPLL patients and 209 control subjects. SNPStats, SNPAnalyzer Pro, Helixtree, and Haploview 4.2 programs were used for association analysis. Multiple logistic regression models (codominant, dominant, and recessive) were calculated for the odds ratios (ORs), 95 % confidence intervals (CIs), and corresponding P values. For multiple testing, Bonferroni correction was performed. After Bonferroni correction, genotype analysis of both rs8190315 and rs2072392 showed association between the OPLL group and the control group in the codominant model (P = 0.042, OR 1.86, 95 % CI 1.10–3.15). A complete linkage disequilibrium block was estimated between the two SNPs. Both of the G allele of rs8190315 and C allele of rs2072392 were strongly associated with an increased risk in the development of OPLL (P = 0.0052, OR 2.66, 95 % CI 1.51–4.68). These results suggest that BID is associated with OPLL, and both the G allele of a missense SNP (rs8190315, Ser10Gly) and C allele of a synonymous SNP (rs2072392, Asp60Asp) are risk factors for the development of OPLL in Korean population.

In this research, the author aims to explore the competing technologies and firms in a convergence industry. The author makes use of patents as a proxy for technology since they are not only the representative measure for technology but are also effective when formulating strategies with regard to firms. In addition, the author adopts the telematics industry as an exemplary convergence industry. In the analysis using US patents from January 2005 until November 2006, 36 major technological fields and 40 major firms are identified.

Dystonia is a movement disorder characterized by involuntary muscle contractions. Patients with dystonia may experience uncontrollable twisting, repetitive movements, or abnormal posture. A 55-year-old man presented with an involuntary left forearm supination, which he had experienced for five years. There was no history of antecedent trauma to the wrist or elbow. Although conventional therapeutic modalities had been performed, the symptoms persisted. When he visited our hospital, electromyography was performed. Reduced conduction velocity was evident at the elbow-axilla segment of the left median nerve. We suspected that there was a problem on the median nerve between the elbow and the axilla. For this reason, we performed an ultrasonography and magnetic resonance imaging study. A spindle-shaped soft tissue mass was observed at the left median nerve that suggested the possibility of neurofibroma. Dystonia caused by traumatic or compressive peripheral nerve injury has often been reported, but focal dystonia due to a neurogenic tumor is extremely rare. Here, we report our case with a review of the literature.

Monomelic amyotrophy (MMA), also known as Hirayama disease, is a sporadic juvenile muscular atrophy in the distal upper extremities. This disorder rarely involves proximal upper extremities and presents minimal sensory symptoms with no upper motor neuron (UMN) signs. It is caused by anterior displacement of the posterior dural sac and compression of the cervical cord during neck flexion. An 18-year-old boy visited our clinic with a 5-year history of left upper extremity pain and slowly progressive weakness affecting the left shoulder. Atrophy was present in the left supraspinatus and infraspinatus. On neurological examination, positive UMN signs were evident in both upper and lower extremities. Electrodiagnostic study showed root lesion involving the fifth to seventh cervical segment of the cord with chronic and ongoing denervation in the fifth and sixth cervical segment innervated muscles. Cervical magnetic resonance imaging (MRI) showed asymmetric cord atrophy apparent in the left side and intramedullary high signal intensity along the fourth to sixth cervical vertebral levels. With neck flexion, cervical MRI revealed anterior displacement of posterior dural sac, which results in the cord compression of those segments. The mechanisms of myelopathy in our patient seem to be same as that of MMA. We report a MMA patient involving proximal limb with UMN signs in biomechanical concerns and discuss clinical importance of cervical MRI with neck flexion. The case highlights that clinical variation might cause misdiagnosis.

Despite the importance of active inter-industrial knowledge flows for national competitiveness, there has been no appropriate indicator through which the patterns of inter-industrial knowledge flow can be examined. Therefore, in this research, we propose various indicators that enable us to comparatively analyse industries in terms of knowledge flow. As proxy measures for knowledge, we make use of patents exhibiting technological knowledge and papers representing scientific knowledge. Although the Korean example may not apply to other countries due to its unique characteristics, the proposed framework will help us examine industrial idiosyncrasies and enable an international comparison.