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5,063 results on '"Yoo, So Young"'

2. Bioelastic state recovery for haptic sensory substitution

Author

Flavin, Matthew T., Ha, Kyoung-Ho, Guo, Zengrong, Li, Shupeng, Kim, Jin-Tae, Saxena, Tara, Simatos, Dimitrios, Al-Najjar, Fatimah, Mao, Yuxuan, Bandapalli, Shishir, Fan, Chengye, Bai, Dongjun, Zhang, Zhuang, Zhang, Yanlin, Flavin, Eunhye, Madsen, Kenneth E., Huang, Yi, Emu, Luoqian, Zhao, Jingyang, Yoo, Jae-Young, Park, Minsu, Shin, Jaeho, Huang, Aaron G., Shin, Hee-Sup, Colgate, J. Edward, Huang, Yonggang, Xie, Zhaoqian, Jiang, Hanqing, and Rogers, John A.

Published
2024
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4. A wirelessly programmable, skin-integrated thermo-haptic stimulator system for virtual reality.

Author

Kim, Jae-Hwan, Vázquez-Guardado, Abraham, Luan, Haiwen, Kim, Jin-Tae, Yang, Da, Zhang, Haohui, Chang, Jan-Kai, Yoo, Seonggwang, Park, Chanho, Wei, Yuanting, Christiansen, Zach, Kim, Seungyeob, Avila, Raudel, Kim, Jong, Lee, Young, Shin, Hee-Sup, Zhou, Mingyu, Jeon, Sung, Baek, Janice, Lee, Yujin, Kim, So, Lim, Jaeman, Park, Minsu, Jeong, Hyoyoung, Won, Sang, Chen, Renkun, Huang, Yonggang, Jung, Yei, Yoo, Jae-Young, and Rogers, John

Subjects
thermo-haptic stimulator, Humans, Wireless Technology, Touch, Virtual Reality, Skin, Robotics
Abstract

Sensations of heat and touch produced by receptors in the skin are of essential importance for perceptions of the physical environment, with a particularly powerful role in interpersonal interactions. Advances in technologies for replicating these sensations in a programmable manner have the potential not only to enhance virtual/augmented reality environments but they also hold promise in medical applications for individuals with amputations or impaired sensory function. Engineering challenges are in achieving interfaces with precise spatial resolution, power-efficient operation, wide dynamic range, and fast temporal responses in both thermal and in physical modulation, with forms that can extend over large regions of the body. This paper introduces a wireless, skin-compatible interface for thermo-haptic modulation designed to address some of these challenges, with the ability to deliver programmable patterns of enhanced vibrational displacement and high-speed thermal stimulation. Experimental and computational investigations quantify the thermal and mechanical efficiency of a vertically stacked design layout in the thermo-haptic stimulators that also supports real-time, closed-loop control mechanisms. The platform is effective in conveying thermal and physical information through the skin, as demonstrated in the control of robotic prosthetics and in interactions with pressure/temperature-sensitive touch displays.

Published
2024

19. Closed-loop network of skin-interfaced wireless devices for quantifying vocal fatigue and providing user feedback.

Author

Yoo, Jae-Young, Ouyang, Wei, Greane, Aurora, Wiebe, Alexandra, Huang, Ivy, Lee, Young, Lee, Jong, Kim, Joohee, Ni, Xinchen, Kim, Suyeon, Huynh, Huong, Zhong, Isabel, Chin, Yu, Gu, Jianyu, Johnson, Aaron, Brancaccio, Theresa, Rogers, John, and Jeong, Hyoyoung

Subjects
closed-loop network, haptic feedback, quantifying vocal fatigue, real-time machine learning, wearable electronics, Humans, Feedback, Voice Disorders, Voice, Vocal Cords, Singing
Abstract

Vocal fatigue is a measurable form of performance fatigue resulting from overuse of the voice and is characterized by negative vocal adaptation. Vocal dose refers to cumulative exposure of the vocal fold tissue to vibration. Professionals with high vocal demands, such as singers and teachers, are especially prone to vocal fatigue. Failure to adjust habits can lead to compensatory lapses in vocal technique and an increased risk of vocal fold injury. Quantifying and recording vocal dose to inform individuals about potential overuse is an important step toward mitigating vocal fatigue. Previous work establishes vocal dosimetry methods, that is, processes to quantify vocal fold vibration dose but with bulky, wired devices that are not amenable to continuous use during natural daily activities; these previously reported systems also provide limited mechanisms for real-time user feedback. This study introduces a soft, wireless, skin-conformal technology that gently mounts on the upper chest to capture vibratory responses associated with vocalization in a manner that is immune to ambient noises. Pairing with a separate, wirelessly linked device supports haptic feedback to the user based on quantitative thresholds in vocal usage. A machine learning-based approach enables precise vocal dosimetry from the recorded data, to support personalized, real-time quantitation and feedback. These systems have strong potential to guide healthy behaviors in vocal use.

Published
2023

23. A phase 2 open-label study of cemiplimab in patients with advanced cutaneous squamous cell carcinoma (EMPOWER-CSCC-1): Final long-term analysis of groups 1, 2, and 3, and primary analysis of fixed-dose treatment group 6

Author

Hughes, Brett G.M., Guminski, Alexander, Bowyer, Samantha, Migden, Michael R., Schmults, Chrysalyne D., Khushalani, Nikhil I., Chang, Anne Lynn S., Grob, Jean-Jacques, Lewis, Karl D., Ansstas, George, Day, Fiona, Ladwa, Rahul, Stein, Brian N., Muñoz Couselo, Eva, Meier, Friedegund, Hauschild, Axel, Schadendorf, Dirk, Basset-Seguin, Nicole, Modi, Badri, Dalac-Rat, Sophie, Dunn, Lara A., Flatz, Lukas, Mortier, Laurent, Guégan, Sarah, Heinzerling, Lucie M., Mehnert, Janice M., Trabelsi, Sabiha, Soria-Rivas, Ainara, Stratigos, Alexander J., Ulrich, Claas, Wong, Deborah J., Beylot-Barry, Marie, Bossi, Paolo, Bugés Sánchez, Cristina, Chandra, Sunandana, Robert, Caroline, Russell, Jeffery S., Silk, Ann W., Booth, Jocelyn, Yoo, Suk-Young, Seebach, Frank, Lowy, Israel, Fury, Matthew G., and Rischin, Danny

Published
2025
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25. Wireless broadband acousto-mechanical sensing system for continuous physiological monitoring

Author

Yoo, Jae-Young, Oh, Seyong, Shalish, Wissam, Maeng, Woo-Youl, Cerier, Emily, Jeanne, Emily, Chung, Myung-Kun, Lv, Shasha, Wu, Yunyun, Yoo, Seonggwang, Tzavelis, Andreas, Trueb, Jacob, Park, Minsu, Jeong, Hyoyoung, Okunzuwa, Efe, Smilkova, Slobodanka, Kim, Gyeongwu, Kim, Junha, Chung, Gooyoon, Park, Yoonseok, Banks, Anthony, Xu, Shuai, Sant’Anna, Guilherme M., Weese-Mayer, Debra E., Bharat, Ankit, and Rogers, John A.

Published
2023
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26. Soft skin-interfaced mechano-acoustic sensors for real-time monitoring and patient feedback on respiratory and swallowing biomechanics.

Author

Kang, Youn, Arafa, Hany, Yoo, Jae-Young, Kantarcigil, Cagla, Kim, Jin-Tae, Yoo, Seonggwang, Oh, Seyong, Kim, Joohee, Wu, Changsheng, Tzavelis, Andreas, Wu, Yunyun, Kwon, Kyeongha, Winograd, Joshua, Xu, Shuai, Martin-Harris, Bonnie, Rogers, John, and Jeong, Hyoyoung

Abstract

Swallowing is a complex neuromuscular activity regulated by the autonomic nervous system. Millions of adults suffer from dysphagia (impaired or difficulty swallowing), including patients with neurological disorders, head and neck cancer, gastrointestinal diseases, and respiratory disorders. Therapeutic treatments for dysphagia include interventions by speech-language pathologists designed to improve the physiology of the swallowing mechanism by training patients to initiate swallows with sufficient frequency and during the expiratory phase of the breathing cycle. These therapeutic treatments require bulky, expensive equipment to synchronously record swallows and respirations, confined to use in clinical settings. This paper introduces a wireless, wearable technology that enables continuous, mechanoacoustic tracking of respiratory activities and swallows through movements and vibratory processes monitored at the skin surface. Validation studies in healthy adults (n = 67) and patients with dysphagia (n = 4) establish measurement equivalency to existing clinical standard equipment. Additional studies using a differential mode of operation reveal similar performance even during routine daily activities and vigorous exercise. A graphical user interface with real-time data analytics and a separate, optional wireless module support both visual and haptic forms of feedback to facilitate the treatment of patients with dysphagia.

Published
2022

35. Miniaturized wireless, skin-integrated sensor networks for quantifying full-body movement behaviors and vital signs in infants.

Author

Kwak, Sung, Sohn, Seokwoo, Lee, Jong, Lee, Young, OBrien, Megan, Park, Yoonseok, Avila, Raudel, Kim, Jin-Tae, Yoo, Jae-Young, Irie, Masahiro, Jang, Hokyung, Ouyang, Wei, Shawen, Nicholas, Kang, Youn, Kim, Seung, Tzavelis, Andreas, Lee, KunHyuck, Andersen, Rachel, Huang, Yonggang, Jayaraman, Arun, Davis, Matthew, Shanley, Thomas, Wakschlag, Lauren, Krogh-Jespersen, Sheila, Xu, Shuai, Ryan, Shirley, Lieber, Richard, Rogers, John, and Jeong, Hyoyoung

Subjects
infants motor skill, motion recapitulation, movement behaviors, wireless sensor networks, Bias, Child, Equipment Design, Heart Rate, Humans, Imaging, Three-Dimensional, Infant, Infant Behavior, Miniaturization, Monitoring, Physiologic, Movement, Respiratory Rate, Skin, Video Recording, Vital Signs, Wireless Technology
Abstract

Early identification of atypical infant movement behaviors consistent with underlying neuromotor pathologies can expedite timely enrollment in therapeutic interventions that exploit inherent neuroplasticity to promote recovery. Traditional neuromotor assessments rely on qualitative evaluations performed by specially trained personnel, mostly available in tertiary medical centers or specialized facilities. Such approaches are high in cost, require geographic proximity to advanced healthcare resources, and yield mostly qualitative insight. This paper introduces a simple, low-cost alternative in the form of a technology customized for quantitatively capturing continuous, full-body kinematics of infants during free living conditions at home or in clinical settings while simultaneously recording essential vital signs data. The system consists of a wireless network of small, flexible inertial sensors placed at strategic locations across the body and operated in a wide-bandwidth and time-synchronized fashion. The data serve as the basis for reconstructing three-dimensional motions in avatar form without the need for video recordings and associated privacy concerns, for remote visual assessments by experts. These quantitative measurements can also be presented in graphical format and analyzed with machine-learning techniques, with potential to automate and systematize traditional motor assessments. Clinical implementations with infants at low and at elevated risks for atypical neuromotor development illustrates application of this system in quantitative and semiquantitative assessments of patterns of gross motor skills, along with body temperature, heart rate, and respiratory rate, from long-term and follow-up measurements over a 3-mo period following birth. The engineering aspects are compatible for scaled deployment, with the potential to improve health outcomes for children worldwide via early, pragmatic detection methods.

Published
2021

43. Neoadjuvant cemiplimab and surgery for stage II–IV cutaneous squamous-cell carcinoma: follow-up and survival outcomes of a single-arm, multicentre, phase 2 study

Author

Gross, Neil D, Miller, David M, Khushalani, Nikhil I, Divi, Vasu, Ruiz, Emily S, Lipson, Evan J, Meier, Friedegund, Su, Yungpo Bernard, Swiecicki, Paul L, Atlas, Jennifer, Geiger, Jessica L, Hauschild, Axel, Choe, Jennifer H, Hughes, Brett G M, Schadendorf, Dirk, Patel, Vishal A, Homsi, Jade, Taube, Janis M, Lim, Annette M, Ferrarotto, Renata, Yoo, Suk-Young, Mathias, Melissa, Han, Hyunsil, Seebach, Frank, Lowy, Israel, Fury, Matthew G, and Rischin, Danny

Published
2023
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45. Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?

Author

Park, JooYong, Choi, Ji-Yeob, Choi, Jaesung, Chung, Seokang, Song, Nan, Park, Sue K, Han, Wonshik, Noh, Dong-Young, Ahn, Sei-Hyun, Lee, Jong Won, Kim, Mi Kyung, Jee, Sun Ha, Wen, Wanqing, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, Shah, Mitul, Conroy, Don M, Harrington, Patricia A, Mayes, Rebecca, Czene, Kamila, Hall, Per, Teras, Lauren R, Patel, Alpa V, Couch, Fergus J, Olson, Janet E, Sawyer, Elinor J, Roylance, Rebecca, Bojesen, Stig E, Flyger, Henrik, Lambrechts, Diether, Baten, Adinda, Matsuo, Keitaro, Ito, Hidemi, Guénel, Pascal, Truong, Thérèse, Keeman, Renske, Schmidt, Marjanka K, Wu, Anna H, Tseng, Chiu-Chen, Cox, Angela, Cross, Simon S, kConFab Investigators, Andrulis, Irene L, Hopper, John L, Southey, Melissa C, Wu, Pei-Ei, Shen, Chen-Yang, Fasching, Peter A, Ekici, Arif B, Muir, Kenneth, Lophatananon, Artitaya, Brenner, Hermann, Arndt, Volker, Jones, Michael E, Swerdlow, Anthony J, Hoppe, Reiner, Ko, Yon-Dschun, Hartman, Mikael, Li, Jingmei, Mannermaa, Arto, Hartikainen, Jaana M, Benitez, Javier, González-Neira, Anna, Haiman, Christopher A, Dörk, Thilo, Bogdanova, Natalia V, Teo, Soo Hwang, Mohd Taib, Nur Aishah, Fletcher, Olivia, Johnson, Nichola, Grip, Mervi, Winqvist, Robert, Blomqvist, Carl, Nevanlinna, Heli, Lindblom, Annika, Wendt, Camilla, Kristensen, Vessela N, Nbcs Collaborators, Tollenaar, Rob AEM, Heemskerk-Gerritsen, Bernadette AM, Radice, Paolo, Bonanni, Bernardo, Hamann, Ute, Manoochehri, Mehdi, Lacey, James V, Martinez, Maria Elena, Dunning, Alison M, Pharoah, Paul DP, Easton, Douglas F, Yoo, Keun-Young, and Kang, Daehee

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Women's Health, Clinical Research, Cancer, Estrogen, Breast Cancer, Human Genome, Genetics, Prevention, Aging, 2.1 Biological and endogenous factors, breast cancer, estrogen, gene-environment interaction, Oncology and carcinogenesis
Abstract

In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 × 10-3). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 × 10-4). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.

Published
2021

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