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In response to the uncertainty of renewable energy output and the fluctuation of load, this paper proposes a hybrid energy storage management strategy based on the State of Charge (SOC) to smooth power fluctuations and thereby improve the power quality of photovoltaic energy storage DC microgrids. Firstly, a hybrid algorithm for power tracking control is formed by incorporating the Particle Swarm Optimization (PSO) algorithm into the variable step-size Incremental Conductance (INC) method, thereby optimizing the maximum power point tracking control system of the photovoltaic system. Then, a first-order filter is employed for the initial allocation of demand power. Taking the SOC of supercapacitors and energy storage batteries as a reference, a secondary power allocation energy management strategy based on rule-based control is proposed to ensure the service life and application safety of the hybrid energy storage system. Finally, simulation experiments are conducted in MATLAB/Simulink 23.2 (R2023b). The results indicate that the proposed energy management strategy can maintain the SOC of the hybrid energy storage system at a reasonable level and effectively smooth DC bus voltage fluctuations.

To achieve a rational allocation of real-time operational equipment, such as excavators and dump trucks, in open-pit mines, and thereby enhance truck–shovel coordination, this paper addresses the challenges posed by unreasonable on-site scheduling, which includes excessive truck waiting times and prolonged excavator boom-and-dipper operations. Ultimately, the paper aims to attain optimal truck–shovel coordination efficiency. To this end, we construct a scheduling optimization model, with the production capacities of trucks and shovels serving as constraints. The objective functions of this model focus on minimizing transportation costs, reducing truck waiting times, and shortening excavator boom-and-dipper operation durations. To solve this model, we have developed an improved genetic algorithm that integrates roulette wheel selection and elite preservation strategies. The experimental results of our algorithm demonstrate that it can provide a more refined operational equipment scheduling scheme, effectively decreasing truck transportation costs and enhancing equipment utilization efficiency in open-pit mines.

The clinical controversy of rosiglitazone as a hypoglycemic agent is potentially associated with heart failure, mainly due to its potent activation of peroxisome proliferator-activated receptor γ (PPARγ). PPARγ partial agonists showed superior pharmacological profiles to rosiglitazone. This study compared differences in cardiac morphology and function of the PPARγ partial agonist CMHX008 with rosiglitazone. High-fat diet (HFD) induced obese mice, ob/ob mice and cardiomyocytes overexpressing PPARγ2 were treated with CMHX008 or rosiglitazone. Heart function, myocardial morphology, and hypertrophy-related gene expression were examined. Clinical information from patients with type 2 diabetes mellitus (T2DM) who had taken rosiglitazone and undergone Doppler echocardiography was collected. HFD and ob/ob mice significantly developed cardiac contractile dysfunction, with upregulated PPARγ2 protein levels in heart tissues. Cardiomyocytes of HFD and ob/ob mice were disorderly arranged, the cell areas expanded, and collagen accumulated. In vitro cardiomyocytes overexpressing PPARγ2 displayed obvious structural abnormalities and high mRNA levels of ANP and BNP, critical cardiac hypertrophy-related genes. HFD-fed mice treated with rosiglitazone or CMHX008 had significantly improved cardiac function, but rosiglitazone induced higher expression of ANP and βMHC and hypertrophic cardiomyopathy, while CMHX008 did not. Patients with T2DM taking rosiglitazone exhibited increased thickness of the posterior wall and the ventricular septum, suggesting cardiac hypertrophy. Our findings show that diabetic cardiomyopathy was associated with ectopic overexpression of PPARγ2. The full agonist rosiglitazone prevents cardiac dysfunction at the expense of compensatory hypertrophy, while the partial agonist CMHX008 shared a comparable protective effect without altering the structure of cardiomyocytes.

The title compound, C24H29N3O5S, is a chiral molecule which crystallizes in a centrosymmetric space group as a racemate. The thiazolidine ring forms the dihedral angles of 29.22 (12) and 67.79 (10)° with the benzene and pyridine rings, respectively. The benzene and pyridine rings are tilted by dihedral angle of 67.18 (9)°. In the crystal, intermolecular C—H...O hydrogen bonds link the molecules into a two-dimensional network.