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Type 2 diabetes mellitus (T2DM) is a multifactorial disorder that leads to alterations in gene regulation. ncRNAs have the characteristics of tissue specificity, disease specificity, timing specificity, high stability and post transcriptional regulation effect. These preconditions are more conducive to promote ncRNA to become a new biomarker for clinical diagnosis. Our study aims to explore the relationship between circRNA, lncRNA, miRNA and T2DM, and to evaluate their diagnostic value for T2DM. A total of 101 pairs of T2DM and controls were conducted in the study. QRT-PCR was used to study the differential expression of circRNAs, miRNAs and lncRNAs. ROC curve was used to estimate their diagnostic value in T2DM. Compared with healthy controls, the expression levels of hsa_circ_0071106, hsa_circ_0000284, hsa_circ_0071271, hsa-miR-29a-5p, hsa-miR-3690, hsa-miR-607, lncRNA MEG3 and lncRNA TUG1were higher in T2DM (all P

This letter presents a orthogonally polarized dual-wavelength single-longitudinal-mode Pr:YLF laser output at 607 nm and 604 nm by using combine F-P etalons. The experimental results shows that switchable single and dual-wavelength single-longitudinal mode laser output can be realized by selectively combining the F-P etalons with 0.3 mm and 1mm thickness. We obtained the maximum orthogonally polarized dual-wavelength single longitudinal mode laser output power at 604 nm and 607 nm is reaches 32 mW and the measured dual-wavelength single longitudinal mode laser spectral line-widths are 174.4 MHz and 102.2 MHz. The maximum single wavelength single longitudinal mode laser output at 607 nm and 604 nm are 201 mW and 81 mW and the measured single wavelength single longitudinal mode laser spectral line-widths are 52.3 MHz and 111.3 MHz, respectively. To the best of our knowledge, it is the first time to investigate the orthogonally polarized dual-wavelength single longitudinal mode CW Pr:YLF laser.

In this paper, we report an external-cavity 2128 nm narrow-linewidth optical parametric oscillator involving a reflective volume Bragg grating. Based on the Sellmeier equation, we introduce the thermal expansion coefficient together with the thermally-induced output wavelength shift. When the pump power is 12.91 W, with the repetition rate being 70 kHz, a 2128 nm laser with an output power of 3.85 W is obtained, having the optical-to-optical conversion efficiency equal to 30% and the linewidth equal to 108 nm. Moreover, the output power is 2.71 W at 2128 nm and the output linewidth is compressed to 0.19 nm, when a reflective volume Bragg grating is used instead of a total reflection mirror, with the corresponding optical-to-optical conversion efficiency being 21% and the beam quality factor being $$ {\mathrm{M}}_x^2 $$ = 1.92 and $$ {\mathrm{M}}_y^2 $$ = 1.98. As a result, a 2128 nm narrow-linewidth laser is implemented.

The Back-n white neutron source at the China Spallation Neutron Source (CSNS) provides neutrons in the continuous energy region from 0.5 eV to 200 MeV. A spectrometer named Light charged Particle Detector Array (LPDA) is designed for the study of (n, lcp) reactions at Back-n. The main detector of the LPDA spectrometer, a 16-unit ΔE-ΔE-E telescope array, is composed of two arrays of 8-unit ΔE-ΔE-E telescope. Each telescope unit consists of a Low-Pressure Multi-Wire Proportional Chamber (LPMWPC), a Si-PIN detector, and a CsI(Tl) scintillator detector. In 2021, a neutron-proton (n-p) scattering reaction cross-section measurement experiment was accomplished as the first experiment of the telescope array. Protons can be clearly identified in the ΔE-E spectrum (LPMWPC + Si-PIN) and the ΔE-E spectrum (Si-PIN + CsI(Tl)). Cross sections of the n-p scattering reaction in the neutron energy range of several MeV are extracted. The ΔE-E method also provides new measurement opportunities for many-body neutron induced light charged-particle emission reactions.

An evaluation model for optimizing system parameters was established in this study using longitudinal-mode pre-lase selection technology. By solving the rate equation and calculating the evaluation function, we determined the evaluation efficiency of a single-longitudinal-mode operation using this scheme. The optimal condition for the characteristics of the single-longitudinal Q-switched laser was also analytically calculated in detail. We observed that the evaluation function derived using the two-step signal of the Q-switch modulation time and other resonator parameters significantly influenced the output characteristics of the single-longitudinal-mode Q-switched laser operation. Furthermore, the experimental results were consistent with the simulations.

A consistent measurement of the inclusive single-neutron removal cross sections of $^{14,15,16}\mathrm{C}$ on a carbon target at around 240 MeV/nucleon has been performed at the External Target Facility, HIRFL-CSR, and compared with Glauber model predictions using shell-model spectroscopic strengths between the initial projectile ground state and configurations of bound core state $+$ valence neutron state as input. For the dependence of the spectroscopic factor reduction characterized by the ratio ${R}_{s}$ of the experimental over theoretical single-nucleon removal cross section on the bounding depth $\mathrm{\ensuremath{\Delta}}S$ of the removed nucleon established in single-nucleon removals with beam energies mainly over 80--120 MeV/nucleon, our measurement gives ${R}_{s}$ values that conform to the earlier ${R}_{s}\text{\ensuremath{-}}\mathrm{\ensuremath{\Delta}}S$ systematics, where the relatively higher incident beam energy facilitates the applicability of the eikonal and sudden approximation used in the Glauber model.

Aluminum and its alloys are widely used in the nuclear industry. Therefore, it is essential to precisely measure and accurately know the neutron total cross section of aluminum in the wider energy region. The measurement is performed by using the transmission method at the Back-n White Neutron Source of CSNS. Two aluminum samples 70 mm in diameter and thicknesses of 40 and 60 mm, respectively, were positioned at 55 m from the neutron source. The transmission detector consisted of a multi-layer fast fission chamber loaded with $$^{235}$$ U and $$^{238}$$ U, and it was located at the 76-m measurement station. By applying the time-of-flight technique, it was possible to extract the n+ $$^{27}$$ Al total cross section in a wide energy region, from 1 eV to 20 MeV, after the correction for the double-bunch mode of the CSNS accelerator. The total cross sections obtained with the two Al samples are consistent and the results obtained with the $$^{235}$$ U fission cells are in good agreement with that with $$^{238}$$ U in the energy range of 1–20 MeV. The uncertainty of neutron total cross section measured with $$^{235}$$ U for 40 mm and 60 mm thick aluminum is 0.7–22.3% and 0.6–12.4% in the energy range of 10 keV–20 MeV. Results are in fair agreement with respect to previous data and evaluations.

A dual-wavelength continuous-wave laser with direct intra-cavity pumping using a 879 nm laser diode that utilizes Nd:GdVO4 and Nd:YVO4 crystals, is presented. To the best of our knowledge, this system completely eliminates the gain competition between the 912 nm and 1064 nm transitions for the first time. A theoretical model is introduced to describe this intra-cavity pumped dual-wavelength laser. The lasing threshold of the 912 nm Nd:GdVO4 laser is presented by considering the ground-state reabsorption loss effect. A total output power of 1.33 W at dual-wavelength operation with an absorbed pump power of 7.91 W is experimentally achieved. The individual output power for the 912 nm and 1064 nm emissions were 0.43 W and 0.9 W, respectively. Both wavelengths operate in TEM00 mode with a total slope efficiency >20%.

In this study, based on the intra-cavity pumped dual-wavelength theoretical model, a reabsorption effect is introduced into a quasi-three-level laser, and a new theoretical model of a dual-wavelength laser with reabsorption effect is presented. Through experiments, the output characteristics of no gain competition 912 nm and 1064 nm dual-wavelength lasers with Nd:GdVO4 and Nd:YVO4 are presented for the first time. Results showed that at an incident pumping power of 38.9 W, the total output power was generally higher than at 3.6 W (1.4 and 2.2 W at 912 nm and 1064 nm, respectively) and the overall optical-to-optical efficiency was > 17%. The fluctuations in the output powers of the 912 nm and 1064 nm lasers were 1.62 and 2.18%, respectively. However, the fluctuation in the total output power was only 0.28% at a pumping power of 27.7 W. The laser mode was TEM00, and the measured M2 values for 912 nm and 1064 nm lasers were 1.35 and 1.28, respectively, under a pumping power of 30 W.

The External Target Facility (ETF) has been constructed for reaction studies with high-energy secondary beams of several hundred MeV/u. The charged fragment detector system of ETF consists of a dipole magnet, tracking drift chambers, ionization chambers and plastic scintillators for particle identification (PID) via B ρ - Δ E-TOF method. The system is now ready for physics experiments. Before physics runs, it has been tested using 280 MeV/u 18O primary beam as well as the secondary beams produced by projectile fragmentation. The system used as a magnetic spectrometer has exhibited satisfying PID capability in identifying fragments ranging from nitrogen to beryllium.

An innovative pulse-diode-intermittent-pumped 2-µm acousto-optically Q-switched Tm:YAG laser is presented for the first time, which can improve the output energy, while ensuring the operation repetition of laser. Maximum output energy of 6.83 mJ and minimum pulse width of 367.7 ns at Q-switched repetition rate of 200 Hz is obtained at pump energy of 86.2 mJ. The output wavelength is 2014.9 nm. The beam quality factor Mx2 is 1.48 and My2 is 1.59. The stability is larger than 98%.

In some existing omnidirectional mobile robots, the movement of each wheel is generally controlled by one driven motor cooperates with one steering motor, such design will increase the energy consumption. This paper investigates an omnidirectional mobile robot based on a special coupling system, so as to solve the above problem. We propose a unique robot's steering method by designing the parallelogram connecting rod as the coupling system, which makes each wheel only need to be equipped with one motor to complete omnidirectional motion and always keep unchanged robot's attitude. In theory, we conduct the structural analysis, dynamic analysis and kinematic analysis of the mobile robot and explain why our system is under-actuated. In experiments, the square trajectory and the serpentine trajectory are exploited to verify the rationality of design and theoretical derivation by comparing the simulation results with the experimental results. By performing mobile robot walking experiments under different ground condition respectively, the stability and adaption of the under-actuated omnidirectional mobile robot is also favourably confirmed. After detailed theoretical analysis and the support of experiments, it is carried out that the under-actuated mechanism proposed in this paper can indeed realize the movement of the robot in all directions. As well as the attitude of the robot always keeps constant, as we expected, enables to realize the steering of robot flexibly even in a narrow space.

The output characteristics of a narrow linewidth, no-gain competition, dual-wavelength solid-state laser using an intra-cavity pumped method are reported. This system consists of an intra-cavity pumped Nd:YVO4 laser emitting at 1064 nm, using a 912 nm Nd:GdVO4 laser. A Fabry-Perot etalon is used to compress the linewidth that located at the common cavity of 912 nm and 1064 nm laser. Theoretical analysis and experimental verification were carried out. When the pump power is 32.8 W, the output of 912 nm and 1064 nm theoretical value is 0.036 W and 0.046 W, and the experimental value is 0.017 W and 0.016 W, respectively. The change trend of the theoretical simulated output power value was the same as the actual measured value in the experiment. In addition to this, the experimental measurement shows when the etalon with an angle of 15?, corresponding minimum linewidths were 0.284 nm and 0.627 nm, respectively.

The relative differential cross sections of the $$^{1}\hbox {H}(n, \,el)$$ reaction have been measured at the China Spallation Neutron Source (CSNS) Back-n white neutron source. A low-density polyethylene sample and a graphite foil were prepared for the foreground and background measurements, respectively. The charged particles were detected using the $${\vartriangle }E-E$$ telescope array of the Light-charged Particle Detector Array (LPDA) system. With 10 $${\vartriangle }E-E$$ telescopes, the relative differential cross sections of the $$^{1}\hbox {H}(n, \,el)$$ reaction were obtained from 70 $$^{\circ }$$ to 160 $$^{\circ }$$ in the center-of-mass system in the neutron energy ( $$E_{\mathrm{n}}$$ ) range from 6.14 to 52.48 MeV (23 energy points). The present work was the first experiment using the $${\vartriangle }E-E$$ telescope array of the LPDA system at CSNS. The present results are in good agreement with previous measurements, evaluations and theoretical calculations. Furthermore, this work is the first measurement in the 6.52 MeV $$\le E_{\mathrm{n}} \le $$ 9.09 MeV, 10.57 MeV $$\le E_{\mathrm{n}} \le $$ 12.43 MeV, and 18.05 MeV $$\le $$ $$E_{\mathrm{n}} \le $$ 20.05 MeV regions.

Back-streaming neutrons from the spallation target of the China Spallation Neutron Source (CSNS) that emit through the incoming proton channel were exploited to build a white neutron beam facility (the so-called Back-n white neutron source), which was completed in March 2018. The Back-n neutron beam is very intense, at approximately 2*10^7 n/cm^2/s at 55 m from the target, and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the slices. In addition, the excellent energy spectrum spanning from 0.5 eV to 200 MeV, and a good time resolution related to the time-of-flight measurements make it a typical white neutron source for nuclear data measurements; its overall performance is among that of the best white neutron sources in the world. Equipped with advanced spectrometers, detectors, and application utilities, the Back-n facility can serve wide applications, with a focus on neutron-induced cross-section measurements. This article presents an overview of the neutron beam characteristics, the experimental setups, and the ongoing applications at Back-n., Comment: 11 pages, 9 figures

The capture cross sections of the 169Tm reaction were measured at the back streaming white neutron beam line (Back-n) of the China Spallation Neutron Source (CSNS) using four C6D6 liquid scintillation detectors. The background subtraction, normalization, and correction were carefully considered in the data analysis to obtain accurate cross sections. For the resonance at 3.9 eV, the R-matrix code SAMMY was used to determine the resonance parameters with the internal normalization method. The average capture cross sections of 169Tm for energy between 30 and 300 keV were extracted relative to the 197Au reaction. The measured cross sections of the 169Tm reaction were reported in logarithmically equidistant energy bins with 20 bins per energy decade with a total uncertainty of 5.4% – 7.0% in this study and described in terms of average resonance parameters using a Hauser-Feshbach calculation with fluctuations. The point-wise cross sections and the average resonance parameters showed fair agreement with the evaluated values of the ENDF/B-VIII.0 library in the energy region studied.

We develop a theoretical model of multimode rate equation that accurately describes mode evolution mechanism of prelase Q-switched Pr3+:YLF single longitudinal mode (SLM). We find that it is important to consider the effect of gain difference when calculating the mode competition time accurately. We identify that there is an optimal parameter for the two step signal of acoustic-optic modulator which determines the stability of SLM output. Then, a visible light direct oscillation Q-switched SLM Pr3+:YLF laser at 639.5 nm is obtained, and the experimental results is agree with the simulation very well.