Search

PurposeThis paper proposes an intelligent fault diagnosis method, which aims to obtain the outstanding fault diagnosis results of the gearbox.Design/methodology/approachAn intelligent fault diagnosis method based on energy entropy-weighted complementary ensemble empirical mode decomposition (EWCEEMD) and support vector machine (SVM) optimized by whale optimization algorithm (WOA) is proposed. The raw signal is first denoised by the wavelet noise reduction method. Then, complementary ensemble empirical mode decomposition (CEEMD) is used to generate several intrinsic mode functions (IMFs). Next, energy entropy is used as an indicator to measure the sensibility of the IMF and converted into a weight coefficient by function. After that, IMFs are linearly weighted to form the reconstruction signal, and several features are extracted from the new signal. Finally, the support vector machine optimized by the whale optimization algorithm (WOA-SVM) model is used for gearbox fault classification using feature vectors.FindingsThe fault features extracted by this method have a better clustering effect and clear boundaries under each fault mode than the unimproved method. At the same time, the accuracy of fault diagnosis is greatly improved.Originality/valueIn most studies of fault diagnosis, the sensitivity of IMF has not been appreciated. In this paper, energy entropy is chosen to quantify sensitivity. In addition, high classification accuracy can be achieved by applying WOA-SVM as the final classification model, improving the efficiency of fault diagnosis as well.

Atherosclerotic plaques belong to the common vascular disease in the aged, which rupture will lead to acute thromboembolic diseases, the leading cause of fatal cardiovascular events. Accumulating evidence indicates that the lncRNAs-miRNAs-mRNA regulatory network plays a critical role in atherosclerosis. Based on RNA sequencing (GSE207252), we constructed expression profiles of lncRNAs, microRNAs, and mRNA in the carotid plaque of atherosclerosis patients and analyzed differentially expressed genes (DEGs). We identified three candidate lncRNAs using two algorithms (LASSO and SVM-RFE): lnc_GLRX3, lnc_FGF7-5, and DISC1FP1). LNCipedia, TargetScan, and miRDB databases were used to predict target miRNAs of lncRNAs and target genes of miRNAs. Gene ontology (GO) functional annotation, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and Gene Set Enrichment Analysis (GSEA) analysis of DEGs was carried out using the R package clusterProfiler. A PPI network was constructed using the STRING website and visualized by Cytoscape. According to the "MCC" method of the plug-in cytoHubba in Cytoscape, ERCC4 was the top hub gene of the PPI network. We constructed a lncRNA_FGF7-5/lncRNA_GLRX3-miR-2681-5p-ERCC4 regulatory network for carotid plaque using lncRNA-miRNA and miRNA-mRNA pairs. Next, lncRNA_FGF7-5 and lncRNA_GLRX3 targeted miR-2681-5p directly to upregulate ERCC4 expression. Silencing of lncRNA_FGF7-5 and lncRNA_GLRX3 promoted apoptosis and TP53 expression in HUVECs treated with ox-LDL; however, these effects were reversed by ERCC4-overexpression. Taken together, these findings indicated that lncRNA_FGF7-5 and lncRNA_GLRX3 together reduced atherosclerosis-induced apoptosis of HUVECs via targeting miR-2681-5p to increase ERCC4 expression, thereby preventing the formation of carotid plaque and finally inhibiting atherosclerosis progression.

PurposeThis paper proposes an improved fatigue life analysis method for optimal design of electric multiple units (EMU) gear, which aims at defects of traditional Miner fatigue cumulative damage theory.Design/methodology/approachA fatigue life analysis method by modifying S–N curve and considering material difference is presented, which improves the fatigue life of EMU gear based on shape modification optimization. A corrected method for stress amplitude, average stress and S–N curve is proposed, which considers low stress cycle, material difference and other factors. The fatigue life prediction of EMU gear is carried out by corrected S–N curve and transient dynamic analysis. Moreover, the gear modification technology combined with intelligent optimization method is adopted to investigate the approach of fatigue life analysis and improvement.FindingsThe results show that it is more corresponded to engineering practice by using the improved fatigue life analysis method than the traditional method. The function of stress and modification amount established by response surface method meets the requirement of precision. The fatigue life of EMU gear based on the intelligent algorithm for seeking the optimal modification amount is significantly improved compared with that before the modification.Originality/valueThe traditional fatigue life analysis method does not consider the influence of working condition and material. The life prediction results by using the method proposed in this paper are more accurate and ensure the safety of the people in the EMU. At the same time, the combination of intelligent algorithm and gear modification can improve the fatigue life of gear on the basis of accurate prediction, which is of great significance to the portability of EMU maintenance.

A multidentate tetrazole molecule based on a TPE core, tetrakis[4-(1H-tetrazol-5-yl)phenyl]ethylene (H4ttpe) with combined advantages of two functional groups, was synthesized by cycloaddition reaction of the corresponding organic benzonitrile derivative and azide salt. Coordination self-assembly of the in situ formed aggregation-induced emission polytetrazole luminogen with cadmium(II) ion produces an unprecedented tetrazolyl-TPE-based microporous cationic metal-organic framework (MOF) with an unusual (4,5,8T14)-connected net of {[Cd4(H4ttpe)2Cl5]·(N3)3}, in which the H4ttpe serves as the first undeprotonated tetrazole ligand of octa-coordinating bridging mode. We investigate, for the first time, the utilization of the luminescent MOF containing a TPE core decorated with tetrazolyl terminals for explosive detection based on the change in fluorescence intensity, which shows high selectivity and efficiency in fluorescence quenching toward TNP detection in water solution.

PurposeThis paper aims to establish the relationship between crosswind speed and pantograph-catenary lateral deviation, as well as quantify the influence of crosswind speed and rod size uncertainty on pantograph-catenary contact reliability.Design/methodology/approachThe closed vector method is used to establish the pantograph-catenary kinematics formula. A new prediction model is proposed by using the bird swarm algorithm to optimize the grey model. The lateral deviation of the pantograph and catenary is predicted via the new model. Then the relationship between the effective length of the rod and operating mileage is inferred by combining the effective length theory with the Gamma process, as well as the pantograph-catenary contact reliability model is established according to reliability theory.FindingsThe results obtained show the impacts of uncertainty design parameters of pantograph rods on pantograph-catenary contact reliability index, and the results at crosswind speed of 0 ms−1 and 5 ms−1 are 5.0630 and 4.1442, respectively. The reliability decreases with the increasing crosswind speed, and can be greater than the reliability calculated for rod size degradation due to long-term use.Originality/valueMost preceding works on pantograph-catenary contact reliability were based on principles of dynamics, without considering the pantograph-catenary relative motion. This research reveals the law of pantograph-catenary relative motion for uncertainty design parameters and crosswind, and quantifies the reliability from the angle of kinematics.

To explore the value of the diagnostic-driven therapy with voriconazole in patients with hematological disorders complicated by invasive fungal disease (IFD).A total of 111 patients with hematological disorders complicated by IFD, treated with voriconazole in the hematology department of the General Hospital of South Theatre Command from July 2019 to July 2020, were retrospectively analyzed to compare the differences between the empirical therapy and the diagnostic-driven therapy on the treatment time of voriconazole, hospitalization days and antifungal efficacy. SPSS 23.0 was used for statistical analysis of data.Compared with the diagnostic-driven therapy group, the empirical therapy group had more IFD high-risk patients, including a higher proportion of agranulocytosis patients (95.2% vs 69.5%, P=0.003). However, there were no significant differences on the treatment time of voriconazole, hospitalization days and antifungal efficacy of voriconazole between the two groups.Using diagnostic-driven therapy in relatively IFD low-risk patients can obtain similar therapeutic outcomes and prognosis as empirical therapy in high-risk patients. Either of two strategies can be used in clinical practice according to the individual conditions of patients.血液病合并侵袭性真菌病患者进行伏立康唑诊断驱动治疗的价值.探讨伏立康唑在血液病合并侵袭性真菌病（IFD）患者中诊断驱动治疗的价值.回顾性分析2019年7月至2020年7月在中国人民解放军南部战区总医院血液科住院接受伏立康唑治疗的111例血液病患者的相关资料，比较经验治疗和诊断驱动治疗对伏立康唑使用时间、平均住院日和抗真菌疗效的差异。运用SPSS 23.0进行数据统计分析.相对于诊断驱动治疗，经验性治疗组有更多的IFD高危患者，粒细胞缺乏患者比例更高（95.2% vs 69.5%，P=0.003），但两组患者的伏立康唑使用时间、住院时间、疗效差异无统计学意义.在相对低危的患者中使用诊断驱动治疗，可获得与高危患者经验性治疗相似的治疗结局和预后，两种策略需根据患者的具体情况做出合适的选择.

Based on the daily monitoring data of urban air quality in Shandong province from 2016 to 2020, combined with socio-economic data such as population density and urbanization rate, as well as meteorological data such as wind speed, temperature, and relative humidity, the methods of geographic weighted regression (GWR), multiscale geographically weighted regression (MGWR), and wavelet analysis were comprehensively applied to explore the temporal and spatial distribution characteristics of air pollutants and their relationship with socio-economic and meteorological elements. The results showed that:① In the past five years, the air quality in Shandong province has shown an overall improvement trend. Except for ozone, the concentrations of SO

A series of Fe(III) complexes [Fe(5-F-sal-N-1,4,7,10)]Y (Y = PF6- for 1, Y = ClO4- for 2, Y = I- for 3 and Y = NO3- for 4) have been prepared. Single-crystal X-ray crystallographic studies show that complex 1 crystallizes in the orthorhombic Pna21 space group and complexes 2-4 have an isomorphous structure and crystallize in the same monoclinic space group, P21/n. Complexes 2-4 have two independent molecules (Fe1 and Fe2) in the unit cell. Magnetic susceptibility measurements demonstrated that complexes 1 and 3 showed a gradual one-step SCO behavior (T1/2 for 1 = 177 K and for 3 = 227 K) without thermal hysteresis. The magnetic behavior of 2 shows an incomplete two-step SCO process at T1/2 = 114 K and 170 K, respectively, while 4 is in a high-spin state at all measured temperatures. A careful evaluation of the supramolecular structures of these complexes revealed correlation between the supramolecular packing forces and their SCO behavior. The crystal structure of 1 consists of a three-dimensional (3D) extended network constructed from N-H⋯F and C-H⋯F hydrogen bonds, and C-H⋯π and C⋯C short contacts. In compounds 2-4, the crystal packing is governed by C⋯C, C-H⋯π and p-π interactions for the Fe1 centers and by C-H⋯π/O interactions for the Fe2 centers, which form 1D chains. Additional interactions (C-H⋯F and N-H⋯O/I) connect the neighboring chains and planes to form a complex supramolecular network. The anion⋯π interactions in 4 provide a means for preventing SCO occurring at low temperatures. This suggests that the supramolecular connectivity of the anions influences the magnetic properties.

In this work, a genetic-algorithm-based Kriging model with multi-point addition sequence optimization strategy is addressed to make up for the shortcomings of Kriging model with single point criterion. This approach combines the multi-point addition strategy with genetic algorithm to enable the Kriging model to efficiently capture the globally optimal solution. Based on this, a multi-level surrogate method is presented by employing a local surrogate model to modify the Kriging global surrogate model, and then applied to design optimization to improve the accuracy and efficiency of global optimization. Meanwhile, a reliability design optimization method based on multi-level surrogate model is studied by dealing with the reliability constraints with an adaptive reliability penalty function. Numerical examples show that the proposed method can find the optimal solution of the object problem with the least calculation cost under the condition of satisfying the reliability constraint.

As a new biomedical bone tissue implant candidate, porous Ti–5Mo–5Cu alloy was developed by powder sintering from TiH2, Mo and Cu powders. Space holder material NH4HCO3 granules were added to regulate the pore characteristics like pore morphology and porosity and then mechanical properties including compressive strength and elastic modulus of the porous titanium alloy. The tailored elastic modulus (1.8–6.4 GPa) and compressive strength (93–152 MPa) of porous Ti–5Mo–5Cu alloys with porosity (49.6–61.8%) and average pore size (103–128 μm) fulfil the preliminary mechanical property and pore characteristics requirements of porous prosthesis. It is expected to be used for hard tissue prosthesis.

The predicted changes in precipitation patterns because of global change have profound effects on terrestrial ecosystems. In the present study, the principle and design details of a rainfall enrichment system (RAINES) for open field experiments in semi-arid and arid ecosystems are presented. The rainfall intensity, validity and uniformity of this experimental facility were also tested. During the period from 2008 to 2010, our data showed that the RAINES was able to simulate rainfall events with different rainfall sizes, frequencies and timing. The greatest advantage of the RAINES was its high uniformity in rainfall distribution over a relatively large experimental surface area (>65 m2), which was important for experimental studies of semi-arid and arid ecosystems where vegetation distribution is sparse. The rainfall validity of RAINES was steadily at 66% or higher as long as the hydraulic pressure exceeded 1.4 KPa and the wind speed was below 2.5 m s-1. Since the RAINES is light-weight, inexpensive and versatile enough to be used to simulate various rainfall events with needed properties in remote fields, it is able to provide reliable simulated rainfall in the field for studying possible responses of soil and vegetation processes to rainfall change in arid and semi-arid ecosystems. The application of the RAINES will improve our understanding on the relationship between water availability and ecosystem processes in arid and semi-arid ecosystems, which will provide useful knowledge for the protection, restoration and sustainable management of semi-arid and arid desert ecosystems worldwide. Los cambios predichos en los modelos de precipitación como resultado del cambio global tienen efectos profundos en los ecosistemas terrestres. Un equipo que simule la lluvia es una herramienta de investigación efectiva para explorar los efectos de los cambios en los modelos de lluvia sin varias restricciones naturales. En el presente estudio, se presentan los principios y detalles de diseño de un equipo simulador de lluvia (RAINES) para estudios a campo en ecosistemas áridos y semiaridos. También se determinaron la intensidad de lluvia, validez y uniformidad del RAINES. Durante el período 2008 al 2010, nuestros datos mostraron que el RAINES fue capaz de simular eventos de lluvia con diferentes cantidades, frecuencias y momentos de lluvia. La mayor ventaja del RAINES fue su gran uniformidad en la distribución de la lluvia sobre una superficie experimental relativamente grande (>65 m2 ). Esto es importante para estudios experimentales en ecosistemas áridos y semiáridos donde la distribución de la vegetación es dispersa. La validez de la lluvia provista por el RAINES fue al menos de 66% siempre y cuando la presión hidráulica excedió los 1.4 KPa y la velocidad del viento fue menor que 2.5 m s-1. El RAINES es de bajo peso, no costoso y lo suficientemente versátil como para ser usado para simular varios eventos de lluvia bajo condiciones de campo distantes. Es capaz de proveer lluvia simulada en forma confiable en el campo para estudiar la respuesta de procesos en el suelo y la vegetación a cambios en la cantidad de lluvia en ecosistemas áridos y semiáridos. El uso del RAINES mejorará nuestro entendimiento en la relación entre la disponibilidad de agua y los procesos en ecosistemas áridos y semiáridos. También proveerá conocimiento útil para la protección, restauración y menejo sustentable de ecosistemas de desierto áridos y semiáridos a escala mundial. Fil: Xin, Zhiming. Chinese Academy of Forestry; China Fil: Qian, Jianqiang. Henan Agricultural University; China Fil: Busso, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; Argentina. Universidad Nacional del Sur. Departamento de Agronomía; Argentina Fil: Wu, Bo. Chinese Academy of Forestry; China Fil: Zhu, Yajuan. Chinese Academy of Forestry; China Fil: Zhang, Jinxin. Chinese Academy of Forestry; China Fil: Li, Yonghua. Chinese Academy of Forestry; China. State Forestry Administration; China Fil: Lu, Qi. Chinese Academy of Forestry; China. State Forestry Administration; China

Cu-0.36wt.%Be-0.46wt.%Co alloy plate with 300 mm in width and 10 mm in thickness prepared by heating-cooling combined mold (HCCM) horizontal continuous casting was cold rolled. Microstructure evolution and mechanical properties of the alloy as well as its deformation mechanism were investigated. The results showed that the as-cast alloy plate had columnar grains along the length direction, good surface quality and elongation of 35%, which was directly large-reduction cold rolled without surface treatment, and the accumulative cold rolling reduction reached 98%. When the reduction was small (20%), numerous dislocations and dislocation cells formed, and the deformation mechanism was dislocation slip. When the reduction was 40%, deformation twins appeared, and interactions between twins and dislocation cells induced strip-like dislocation cells. When the reduction exceeded 60%, shear bands formed and apparent crystal rotation in the micro-region happened. Further increasing the reduction, the amount of the shear bands rose and they interacted with each other, which refined the grains apparently. The tensile strength and hardness increased from 353 MPa and HV 119 of the as-cast alloy to 625 MPa and HV 208 with 95% reduction, respectively, and the elongation reduced from 35% to 7.6%. A process of HCCM horizontal continuous casting-cold rolling can work as a novel compact method to fabricate Cu-Be alloy sheet.

Porous TiNb-based alloys have attracted considerable attention in the medical field of orthopedic applications because of excellent biocompatibility, porous architecture, appropriate mechanical pro...

The carrier dynamics of two isomers, α-NPB and β-NPB, were investigated through impedance spectroscopy based on the PSO algorithm. Their structure differences are only the N atom substitution sites...

This paper reports the syntheses, crystal structures and magnetic properties of spin crossover (SCO) salts of formulae [Mn(naphth-sal-N-1,5,8,12)]SbF6 (1), [Mn(naphth-sal-N-1,5,8,12)]AsF6 (2), [Mn(naphth-sal-N-1,5,8,12)]PF6·1/2CH3OH (3) and [Mn(naphth-sal-N-1,5,8,12)]ClO4 (4), where (naphth-sal-N-1,5,8,12)2- (2,2'-((1E,14E)-2,6,10,14-tetraazapentadeca-1,14-diene-1,15-diyl)diphenolate) is a big conjugated hexadentate Schiff-base ligand. Magnetic susceptibility measurements demonstrated that complexes 1 and 2 showed a gradual one-step SCO between the high-spin (HS, S = 2) and low-spin (LS, S = 1) states without thermal hysteresis. The transition temperatures T1/2 of the SbF6 (1) and AsF6 (2) salts estimated from the magnetic susceptibility measurements are 164 and 171 K, respectively. The existence of the crystal solvent of complex 3 changes the supramolecular packing, leading to close ππ stacking interactions between the phenyl groups of the ligands. These close stacking interactions hinder the flexibility of the whole ligand, precluding the spin transformation of complex 3 and leading to its stabilization in the HS state in the temperature range of 2-300 K. For 4, crystal structure analysis indicates that the reduction in the anion size leads to close contacts between the naphthalene rings. These C-Hπ interactions provide a means for preventing the spin crossover occurring at low temperatures.

Deep blue fluorescent materials are crucial in the commercialization of organic light-emitting diodes (OLEDs) for full-color displays or solid-state lighting sources. In this work, a series of aromatic ring compounds, based on a newly designed 2-(pyridine-4-yl)-3-phenyl-1H-benzo[g]indole core, have been synthesized, on which donor (D) and acceptor (A) groups are bonded in a Ψ-type configuration, forming a D–π–A–π–D structure. The electronic structure and photophysical properties have been explored, as well as the applications in the blue OLEDs. The results show that multistate couplings exist between the three D–π–A–π–D moieties, resulting in a high photoluminescence quantum yield up to 76.01% peaking at around 410 nm, and a depressed efficiency roll-off at high luminance. The deep blue OLEDs based on CzCNBPyIp emitter exhibits stable emission peaking at 416 nm with a negligible efficiency roll-off at a high luminance range of 1 000–10 000 cd m−2, and corresponding CIEx,y = (0.162, 0.085) and maximum EQE = 2.6%, making it one of the highest performing solution-processed deep blue fluorescent devices. This work provides an alternative method for the deep blue fluorescent material design toward solution processing OLEDs.

The reaction of chelating 1,2-disilyl hydrides with transition metal precursors featuring low steric hindrance phosphine ligands always produces multinuclear frameworks through mononuclear silyl metal intermediates. Capture of intermediates is very essential to clarify the formation mechanism and structural features of multinuclear species. Here, we succeed in trapping and characterizing two mononuclear platinum and palladium silyl intermediates 4 and 5 by changing the steric hindrance of the substituents and/or ultilizing the intermediate's unique chemical reactivity, and a very unique nickel(II) 6 unprecedently, which is the first structurally characterized dinuclear silyl nickel(II) complex with a bridging μ2-disilene unit.

Aims Exercise confers protection against cardiovascular ageing, but the mechanisms remain largely unknown. This study sought to investigate the role of fibronectin type-III domain-containing protein 5 (FNDC5)/irisin, an exercise-associated hormone, in vascular ageing. Moreover, the existence of FNDC5/irisin in circulating extracellular vesicles (EVs) and their biological functions was explored. Methods and results FNDC5/irisin was reduced in natural ageing, senescence, and angiotensin II (Ang II)-treated conditions. The deletion of FNDC5 shortened lifespan in mice. Additionally, FNDC5 deficiency aggravated vascular stiffness, senescence, oxidative stress, inflammation, and endothelial dysfunction in 24-month-old naturally aged and Ang II-treated mice. Conversely, treatment of recombinant irisin alleviated Ang II-induced vascular stiffness and senescence in mice and vascular smooth muscle cells. FNDC5 was triggered by exercise, while FNDC5 knockout abrogated exercise-induced protection against Ang II-induced vascular stiffness and senescence. Intriguingly, FNDC5 was detected in human and mouse blood-derived EVs, and exercise-induced FNDC5/irisin-enriched EVs showed potent anti-stiffness and anti-senescence effects in vivo and in vitro. Adeno-associated virus-mediated rescue of FNDC5 specifically in muscle but not liver in FNDC5 knockout mice, promoted the release of FNDC5/irisin-enriched EVs into circulation in response to exercise, which ameliorated vascular stiffness, senescence, and inflammation. Mechanistically, irisin activated DnaJb3/Hsp40 chaperone system to stabilize SIRT6 protein in an Hsp70-dependent manner. Finally, plasma irisin concentrations were positively associated with exercise time but negatively associated with arterial stiffness in a proof-of-concept human study. Conclusion FNDC5/irisin-enriched EVs contribute to exercise-induced protection against vascular ageing. These findings indicate that the exerkine FNDC5/irisin may be a potential target for ageing-related vascular comorbidities.

We carried out pot experiment to investigate nitrogen transformation characteristics, yield increasing effect, and apparent utilization rate of nitrogen fertilizer in loess soils by combining chemi-cal inhibitor and biostimulant humic acid to investigate the application effect and provide a theoretical basis for new type highly efficient and stable urea in loess soil. In this study, blank (CK) and urea (N) were set as controls, and humic acid alone (F), N-butyl thiophosphate-triamine (NBPT), 3,4-dimethyl-pyrazolate phosphate (DMPP), 2-chloro-6-trimethyl-pyridine (CP) and humic acid were respectively combined with three biochemical inhibitors to urea. The results showed that compared with N treatment, F, NBPT+F, DMPP+F, CP+F treatments significantly increased maize yield, chlorophyll content, leaf area index and nitrogen uptake, and had obvious effects on soil available nitrogen contents. The addition of humic acid increased chlorophyll content of maize leaves in all cases compared to the application of biochemical inhibitors alone. Compared with CP treatment, CP+F treatment could significantly increase nitrogen uptake, chlorophyll content, and nitrogen adsorption efficiency of maize. Addition of humic acid with NBPT increased nitrification inhibition rate by 10.7% compared with NBPT alone, but decreased yield, leaf area index, nitrogen uptake, nitrogen use efficiency. Compared with DMPP treatment, DMPP+F treatment significantly reduced maize yield, leaf area index, nitrogen uptake, nitrogen use efficiency and nitrification inhibition rate. Considering maize yield, plant N uptake, N fertilizer uptake rate and soil ammonium N and nitrate N contents, the addition of humic acid and CP is recommended for urea application in loess areas to enhance urea performance, yield, and fertilizer utilization.采用田间盆栽试验,研究生化抑制剂与生物刺激素腐植酸结合制成的高效稳定性增效尿素肥料在黄土中的氮素转化特征、增产效果和氮素肥料表观利用率,以探明其施用效果,为开发适宜黄土施用的新型增效尿素肥料提供理论依据。本研究以不施氮肥(CK)和施尿素氮肥(N)为对照,在尿素中分别添加腐植酸(F)、N-丁基硫代磷酰三胺(NBPT)、3,4-二甲基吡唑磷酸盐(DMPP)和2-氯-6-三甲基吡啶(CP),以及腐植酸与3种生化抑制剂分别组合(NBPT+F、DMPP+F、CP+F)。结果表明: 与N处理相比,F、NBPT+F、DMPP+F和CP+F处理均能显著提高玉米的产量、叶片叶绿素含量、叶面积指数和植株吸氮量,对土壤铵态氮和硝态氮含量也有显著影响。与单独施用生化抑制剂相比,添加腐植酸可提高玉米叶片叶绿素含量。与CP相比,CP+F玉米的植株吸氮量、叶绿素含量、氮肥吸收利用率均显著提高;与NBPT相比,NBPT+F硝化抑制率提高10.7%,但玉米产量、叶面积指数、植株吸氮量和氮肥利用率等均有所降低;与DMPP相比,DMPP+F显著降低了玉米产量、叶面积指数、植株吸氮量、氮肥利用率和硝化抑制率等。综合玉米产量、植株吸氮量、氮肥吸收利用率以及土壤铵态氮、硝态氮含量等指标,在黄土地区施用尿素肥料时,建议添加腐植酸和CP以提升尿素性能,从而提高产量和肥料利用率。.