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628 results on '"Yoneyama, Y."'

1. Non-linear charge oscillation driven by a single-cycle light-field in an organic superconductor

Author

Kawakami, Y., Amano, T., Yoneyama, Y., Akamine, Y., Itoh, H., Kawaguchi, G., Yamamoto, H., Kishida, H., Itoh, K., Sasaki, T., Ishihara, S., Tanaka, Y., Yonemitsu, K., and Iwai, S.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

Intense light-field application to solids produces enormous/ultrafast non-linear phenomena such as high-harmonic generations 1, 2 and attosecond charge dynamics 3, 4. They are distinct from conventional photonics. However, main targets have been limited to insulators and semiconductors, although theoretical approaches have been made also for correlated metals and superconductors 5. Here, in a layered organic superconductor, a non-linear charge oscillation driven by a nearly single-cycle strong electric field of >10 megavolts /cm is observed as a stimulated emission. The charge oscillation is different from a linear response and ascribed to a polar charge oscillation with a period of 6 fs. This non-linear polar charge oscillation is enhanced by critical fluctuations near a superconducting transition temperature and a critical end point of first order Mott transitions. Its observation on an ultrafast timescale of 10 fs clarifies that the Coulomb repulsion plays an essential role in superconductivity of organic superconductors., Comment: 5 Figs. for main text, 3 Figs for supplementary information

Published
2018
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2. Polarization selectivity of charge localization induced by 7-fs nearly single-cycle light-field in an organic metal

Author

Kawakami, Y., Yoneyama, Y., Amano, T., Itoh, H., Yamamoto, K., Nakamura, Y., Kishida, H., Sasaki, T., Ishihara, S., Tanaka, Y., Yonemitsu, K., and Iwai, S.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

Polarization selectivity of light-field-induced charge localization was investigated in an organic metal alpha-(BEDT-TTF)2I3 with a triangular lattice. Dependences of transient reflectivity spectra on polarizations of the 7-fs pump and probe lights indicate that a short-range charge order (CO) is efficiently induced from the metallic phase for the pump polarization perpendicular to the 1010-type CO axis. Numerical solution of a time-dependent Schrodinger equation clarified that the 1010-CO is induced by field-induced re-distribution of charges cooperating with competing inter-site Coulomb repulsions in the triangular lattice., Comment: accepted Phys. Rev. B (rapid commun.)

Published
2017
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20. Subjective Evaluation of Denture Adhesives: A Multicenter Randomized Controlled Trial

Author

Ohwada, G., primary, Minakuchi, S., additional, Sato, Y., additional, Kondo, H., additional, Nomura, T., additional, Tsuboi, A., additional, Hong, G., additional, Itoh, Y., additional, Kawai, Y., additional, Kimoto, S., additional, Gunji, A., additional, Suzuki, A., additional, Suzuki, T., additional, Kimoto, K., additional, Hoshi, N., additional, Saita, M., additional, Yoneyama, Y., additional, Morokuma, M., additional, Okazaki, J., additional, Maeda, T., additional, Nakai, K., additional, Ichikawa, T., additional, Nagao, K., additional, Fujimoto, K., additional, Murata, H., additional, Kurogi, T., additional, Yoshida, K., additional, Nishimura, M., additional, Nishi, Y., additional, Murakami, M., additional, Hosoi, T., additional, and Hamada, T., additional

Published
2019
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21. Glucose deprivation attenuates sortilin levels in skeletal muscle cells

Author

Ariga, M., Yoneyama, Y., Fukushima, Toshiaki, Ishiuchi, Y., Ishii, T., Sato, H., Hakuno, F., Nedachi, T., and Takahashi, S. I.

Subjects
Multiprotein Complexes/antagonists & inhibitors/metabolism, 0301 basic medicine, Blood Glucose, Male, Blood Glucose/*analysis, Endocrinology, Diabetes and Metabolism, Glucose uptake, RNA, Messenger/metabolism, Up-Regulation/drug effects, 0302 clinical medicine, Endocrinology, Diabetes Mellitus, Experimental/blood/*metabolism/pathology, Glucose/metabolism, Myocyte, Down-Regulation/drug effects, biology, Chemistry, Myogenesis, TOR Serine-Threonine Kinases, Cell Differentiation, Fasting, musculoskeletal system, Hindlimb, Up-Regulation, medicine.anatomical_structure, C2C12, medicine.medical_specialty, Down-Regulation, Protein degradation, Mechanistic Target of Rapamycin Complex 1, Cell Line, Diabetes Mellitus, Experimental, 03 medical and health sciences, Internal medicine, medicine, Animals, RNA, Messenger, Adaptor Proteins, Vesicular Transport/agonists/genetics/*metabolism, Rats, Wistar, Fasting/*metabolism, Muscle, Skeletal, Protein Kinase Inhibitors, Sirolimus, Muscle Cells, Muscle Cells/cytology/drug effects/metabolism/pathology, Glucose transporter, Sirolimus/pharmacology, Skeletal muscle, TOR Serine-Threonine Kinases/antagonists & inhibitors/metabolism, Adaptor Proteins, Vesicular Transport, 030104 developmental biology, Glucose, Protein Kinase Inhibitors/pharmacology, Multiprotein Complexes, biology.protein, Muscle, Skeletal/cytology/drug effects/*metabolism/pathology, Food Deprivation, 030217 neurology & neurosurgery, GLUT4
Abstract

In skeletal muscle, sortilin plays a predominant role in the sorting of glucose transporter 4 (Glut4), thereby controlling glucose uptake. Moreover, our previous study suggested that the sortilin expression levels are also implicated in myogenesis. Despite the importance of sortilin in skeletal muscle, however, the regulation of sortilin expression has not been completely understood. In the present study, we analyzed if the sortilin expression is regulated by glucose in C2C12 myocytes and rat skeletal muscles in vivo. Sortilin protein expression was elevated upon C2C12 cell differentiation and was further enhanced in the presence of a high concentration of glucose. The gene expression and protein degradation of sortilin were not affected by glucose. On the other hand, rapamycin partially reduced sortilin induction by a high concentration of glucose, which suggested that sortilin translation could be regulated by glucose, at least in part. We also examined if the sortilin regulation by glucose was also observed in skeletal muscles that were obtained from fed or fasted rats. Sortilin expression in both gastrocnemius and extensor digitorum longus (EDL) muscle was significantly decreased by 17-18h of starvation. On the other hand, pathological levels of high blood glucose did not alter the sortilin expression in rat skeletal muscle. Overall, the present study suggests that sortilin protein levels are reduced under hypoglycemic conditions by post-transcriptional control in skeletal muscles.

Published
2016

28. The novel functions of high-molecular-mass complexes containing insulin receptor substrates in mediation and modulation of insulin-like activities: Emerging concept of diverse function by IRS-associated proteins

Author

Hakuno, F., Fukushima, Toshiaki, Yoneyama, Y., Kamei, H., Ozoe, A., Yoshihara, H., Yamanaka, D., Shibano, T., Sone-Yonezawa, M., Yu, B. C., Chida, K., and Takahashi, S.

Subjects
medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Review, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Receptor tyrosine kinase, insulin-like growth factor, Insulin-like growth factor, IRS-associated protein, Endocrinology, IRSome, Internal medicine, Insulin receptor substrate, medicine, insulin receptor substrate, Insulin, Insulin-like growth factor 1 receptor, Cancer, lcsh:RC648-665, biology, insulin receptor substrate (IRS), GRB10, IRS-associated protein (IRSAP), insulin-like growth factor (IGF), IRS2, Cell biology, Insulin receptor, biology.protein
Abstract

Insulin-like peptides, such as insulin-like growth factors (IGFs) and insulin, induce a variety of bioactivities, such as growth, differentiation, survival, increased anabolism, and decreased catabolism in many cell types and in vivo. In general, IGFs or insulin bind to IGF-I receptor (IGF-IR) or insulin receptor (IR), activating the receptor tyrosine kinase. Insulin receptor substrates (IRSs) are known to be major substrates of receptor kinases, mediating IGF/insulin signals to direct bioactivities. Recently, we discovered that IRSs form high-molecular-mass complexes (referred to here as IRSomes) even without IGF/insulin stimulation. These complexes contain proteins (referred to here as IRSAPs; IRS-associated proteins), which modulate tyrosine phosphorylation of IRSs by receptor kinases, control IRS stability, and determine intracellular localization of IRSs. In addition, in these complexes, we found not only proteins that are involved in RNA metabolism but also RNAs themselves. Thus, IRSAPs possibly contribute to modulation of IGF/insulin bioactivities. Since it is established that disorder of modulation of insulin-like activities causes various age-related diseases including cancer, we could propose that the IRSome is an important target for treatment of these diseases.

Published
2015

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