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Your search keyword '"Yolmo, Priyanka"' showing total 12 results
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12 results on '"Yolmo, Priyanka"'

7. Atypical B cells mediate poor response to Bacillus Calmette Guérin immunotherapy in non-muscle invasive bladder cancer

Author

Yolmo, Priyanka, primary, Rahimi, Sadaf, additional, Chenard, Stephen, additional, Conseil, Gwenaëlle, additional, Jenkins, Danielle, additional, Sachdeva, Kartik, additional, Emon, Isaac, additional, Hamilton, Jake, additional, Xu, Minqi, additional, Rangachari, Manu, additional, Michaud, Eva, additional, Mansure, Jose, additional, Kassouf, Wassim, additional, Berman, David M., additional, Siemens, D. Robert, additional, and Koti, Madhuri, additional

Published
2022
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10. Additional file 1 of Sex differences in the aging murine urinary bladder and influence on the tumor immune microenvironment of a carcinogen-induced model of bladder cancer

Author

Hamade, Ali, Li, Deyang, Tyryshkin, Kathrin, Xu, Minqi, Conseil, Gwenaelle, Yolmo, Priyanka, Hamilton, Jake, Chenard, Stephen, Robert Siemens, D., and Koti, Madhuri

Abstract

Additional file 1: Figure S1. Unsupervised log2 mean-centered heatmap of RNA sequencing data of the top 25% ranked genes between and within sexes. Figure S2. C57BL/6 mice show increased immune associated pathway enrichment in an age- and sex-dependant manner. Figure S3. Age and sex related shifts in B cells in healthy murine urinary bladders. Figure S4. Hematoxylin and eosin (H&E) stained section from 5-month-old female (A) and age matched male (B) bladder at 12 weeks post BBN exposure. Tertiary lymphoid structure (black boxes) in the lamina propria of 15-month-old female (C) and age matched male (D) bladders at 7 weeks post BBN. Figure S5. Bladder microenvironment following exposure to BBN carcinogen. Figure S6. Differences in infiltration patterns of select immune markers between 12-month-old male and female mice. Figure S7. Cell Detection using StarDist extension tool of QuPath software.

Published
2022
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12. Atypical B cells promote cancer progression and poor response to Bacillus Calmette-Guérin in non-muscle invasive bladder cancer.

Author

Yolmo P, Rahimi S, Chenard S, Conseil G, Jenkins D, Sachdeva K, Emon I, Hamilton J, Xu M, Rangachari M, Michaud E, Mansure JJ, Kassouf W, Berman DM, Siemens DR, and Koti M

Abstract

Poor response to Bacillus Calmette-Guérin (BCG) immunotherapy remains a major barrier in the management of patients with non-muscle invasive bladder cancer (NMIBC). Multiple factors are associated with poor outcomes, including biological aging and female sex. More recently, it has emerged that a B-cell infiltrated pre-treatment immune microenvironment of NMIBC tumors can influence the response to intra-vesically administered BCG. The mechanisms underlying the roles of B cells in NMIBC are poorly understood. Here, we show that B-cell dominant tertiary lymphoid structures (TLSs), a hallmark feature of the chronic mucosal immune response, are abundant and located close to the epithelial compartment in pre-treatment tumors from BCG non-responders. Digital spatial proteomic profiling of whole tumor sections from male and female patients with NMIBC who underwent treatment with intravesical BCG, revealed higher expression of immune exhaustion-associated proteins within the tumor-adjacent TLSs in both responders and non-responders. Chronic local inflammation, induced by the N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) carcinogen, led to TLS formation with recruitment and differentiation of the immunosuppressive atypical B-cell (ABC) subset within the bladder microenvironment, predominantly in aging female mice compared to their male counterparts. Depletion of ABCs simultaneous to BCG treatment delayed cancer progression in female mice. Our findings provide evidence indicating a role for ABCs in BCG response and will inform future development of therapies targeting the B cell-exhaustion axis.

Published
2024
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