139 results on '"Yoldemir T"'
Search Results
2. Obstetric outcomes of recurrent pregnancy loss patients diagnosed wıth inherited thrombophilia
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Karadağ, C., Yoldemir, T., Karadağ, S. D., İnan, C., Dolgun, Z. N., and Aslanova, L.
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- 2017
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3. Telemedicine and women’s health
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Yoldemir, T., primary
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- 2022
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4. Postmenopausal hyperandrogenism
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Yoldemir, T., primary
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- 2021
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5. Endocrinology and reproductive medicine
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Mardi A., Rahimi G., Amani M., Mashoufi M., Kheirkhah M., Ghaffari Novin M., Pierovi T., Soleimani Rad J., Vanlioglu F., Karaman Y., Bingol B., Tavmergen E., Akdogan A., Akman A., Levi R., Tavmergen Goker EN., Ates U., Seyhan A., Atmaca U., Ortakuz S., Ata B., Akar S., Usta T., Özdemir B., Sidal B., Yoldemir T., Gee A., Sutherland P., Bowman M., Fraser I. S., Haydardedeoglu B., Bagis T., Kilicdag E. B., Simsek E., Aslan E., Zeyneloglu H. B., Kahyaoglu S., Turgay I., Ertas E., Yilmaz B., Var T., Batioglu S., Muftuoglu K., Tekcan C., Naki M. M., Uysal A., Güzin K., Yücel N., Kanadikirik F., Kelekci S., Savan K., Kalyoncu S., Gokturk U., Oral H., Mollamahmutoglu L., Ertas I. E., Mollamahmutoglu L., Kahveci S., Dogan M., Mollamahmutoglu L., Isik A., Saygili U., Gol M., Koyuncuoglu M., Uslu T., Erten O., Ciftci B., Biri A., Bozkurt N., Karabacak O., Himmetoglu O., Amir Jannati N., Nouri M., Hascalik S., Celik O., Parlakpinar H., Mizrak B., Ozsahin M., Önder C., Gezginc K., Colakoglu M., Demir S. C., Cetin M. T., Kadayifci O., Güzel A. B., Polat I., Yildirim G., Özdemir A., Tekirdag Ali I., Kizkin S., Engin-Ustun Y., Ustun Y., Ozcan C., Serbest S., Ozisik H. I., Ergenoglu M., Goker E. N. T., Uckuyu A., Ozcimen E. E., Nisanoglu O., Onal C., Akgun S., Koc S., Cebi Z., Sönmez S., Yasar L., Küpelioglu L., Bilecan S., Aygün M., Zebitay A. G., Dursun P., Ötegen Ü., Bozdag G., Yarali H., Demirci F., Mun S., Eraydin E., Sadik S., Sipahi C., Bayol Ü., Sarikaya S., Garipoglu Dalgin E., Delilbasi L., Gursoy R., Engin-Ustun Y., Meydanli M. M., Atmaca R., Kafkasli A., Canda M. T., Kucuk M., Bagriyanik H. A., Ozyurt D., Canda T., Güven M. A., Tamsoy S., Kaymak O., Ozkale D., Okyay R. E., Neslihanoglu R., Mollamahmutoglu L., Basaran A., Gultekin M., Saygili Yilmaz E., Esinler I., Bayer U., Gunalp S., Aksu T., Gultekin M., Leventerler H., Taga S., Cetin T., Solmaz S., Dikmen N., Karalök H., Ilter E., Tufekci C., Yilmaz S., Karalök A. E., Batur O., Kilicdag E., Haydardedeoglu B., Tarim E., Api M., Gültekin E., Görgen H., Cetin A., Yayla M., Özkilic T., Arikan I., Abali R., Arikan D., Bozkurt S., Demir B., Gunalp S., Erden A. C., Özcan J., Yazicioglu F., and Demirbas R.
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- 2005
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6. Menopause
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Tutuncu L., Arslanhan N., Ergur A. R., Mungen E., Yergok Y. Z., An E. S., Uner M., Eryilmaz M., Akar M. E., Inan I., Kelekci S., Yilmaz B., Kart C., Günaydin A. S., Cakir A., Yilmaz B., Oguz S., Gunyeli I., Kelekci S., Kalyoncu S., Ertas I. E., Kahyaoglu S., Gokturk U., Mollamahmutoglu L., Elter K., Yildizhan B., Basgul A., Pekin T., Gokaslan H., Kavak Z. N., Karas C., Gol M., Guclu S., Dogan E., Saygili U., Onvural A., Gol M., Akan P., Dogan E., Karas C., Saygili U., Posaci C., Biri A., Yurtcu E., Ciftci B., Ergun M. A., Gursoy R., Biberoglu K., Ozcagli E., Sardas S., Erkan A., Ergun M. A., Yilmaz A., Tiras B., Guner H., Yalcin R., Bozkurt N., Gursoy R., Yildirim M., Karabacak O., Himmetoglu O., Gulbahar O., Gursoy R., Nas T., Eskioglu A., Kumru S., Yildiz M. F., Godekmerdan A., Gürates B., Kiran H., Kiran G., Ekerbicer H. C., Guven A. M., Ürünsak I. F., Güzel A. B., Demir S. C., Kadayifci O., Dursun P., Gultekin M., Bozdag G., Aksan G., Aksu T., Bayrak A., Esinler D., Oguz S., Tapisiz O. L., Aytan H., Gunyeli I., Erdem S., Tuncay G., Mollamahmutoglu L., Aksakal O., Aytan H., Cavkaytar S., Tapisiz O. L., Gungor T., Ozdal B., Akhan S. E., Hanli U., Kalayci R., Kaya M., Ahisali B., Turfanda A., Hassa H., Tanir H. M., Tekin B., Oge T., Kahraman S., Yildirim A., Ürünasak I. F., Güzel A. B., Demir S. C., Özbilen N., Kadayifci O., Dane C., Cetin A., Dane B., Kiray M., Erginbas M., Döventas Y., Karabeyoglu N., Dursun P., Gultekin M., Aksu T., Kalli E., Kiran H., Kiran G., Guven A. M., Karakus S., Sapmaz K., Cetin T. M., Canda M. T., Bagriyanik H. A., Kaplan P. B., Yilmaz O., Gucer F., Yuce M. A., Tugyan K., Yoldemir T., Davas I., Tanrikulu A., Yazgan A., and Varolan A.
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- 2005
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7. Postmenopausal hyperandrogenism.
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Yoldemir, T.
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HYPERTRICHOSIS , *ADRENAL tumors , *ADRENOGENITAL syndrome , *HYPERANDROGENISM , *CUSHING'S syndrome , *OVARIAN tumors , *POLYCYSTIC ovary syndrome - Abstract
Postmenopausal hyperandrogenism is a state of relative or absolute androgen excess originating from the adrenal glands and/or ovaries clinically manifested by the presence of terminal hair in androgen-dependent areas of the body, and other manifestations of hyperandrogenism such as acne and alopecia or the development of virilization. In such circumstances, physicians must exclude the possibility of rare but serious androgen-producing tumors of the adrenal glands or ovaries. Worsening of undiagnosed hyperandrogenic disorders such as polycystic ovary syndrome, congenital adrenal hyperplasia, ovarian hyperthecosis, Cushing syndrome and iatrogenic hyperandrogenism should be considered for differential diagnosis. Elevated serum testosterone not only causes virilizing effects, but also will lead to hypercholesterolemia, insulin resistance, hypertension and cardiac disease. An ovarian androgen-secreting tumor, which is diagnosed in 1–3 of 1000 patients presenting with hirsutism, comprises less than 0.5% of all ovarian tumors. Adrenal tumors, including non-malignant adenomas and malignant carcinomas, are less common than ovarian tumors but cause postmenopausal virilization. Measurement of serum testosterone, sex hormone-binding globulin, dehydroepiandrosterone sulfate, androstenedione and inhibin B is necessary in postmenopausal women with the complaints and signs of hyperandrogenism. Some tests to discard Cushing syndrome should also be done. After an etiological source of androgen hypersecretion has been suspected, we recommend performing magnetic resonance imaging of the adrenal glands or ovaries. Medical management with gonadotropin-releasing hormone agonist/analogues or antagonists has been reported for women who are either unfit for surgery or in whom the source of elevated testosterone is unidentified. [ABSTRACT FROM AUTHOR]
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- 2022
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8. Sexual function through decades: association with androgens and cardiometabolic features
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Yoldemir, T., primary, Garibova, N., additional, and Atasayan, K., additional
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- 2020
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9. Assessment and management of B3 breast lesions with atypia: a focused review
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Ugurlu, M. U., primary, Yoldemir, T., additional, and Gulluoglu, B. M., additional
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- 2019
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10. The association between sexual dysfunction and metabolic syndrome among Turkish postmenopausal women
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Yoldemir, T., primary, Garibova, N., additional, and Atasayan, K., additional
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- 2019
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11. Assessment and management of B3 breast lesions with atypia: a focused review.
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Ugurlu, M. U., Yoldemir, T., and Gulluoglu, B. M.
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PAPILLOMA , *CORE needle biopsy , *SURGICAL excision , *BREAST , *LOBULAR carcinoma , *PATHOLOGY , *BREAST tumor diagnosis , *EARLY detection of cancer , *MAMMOGRAMS , *RISK assessment , *PRECANCEROUS conditions , *NEEDLE biopsy ,BREAST tumor prevention - Abstract
Breast lesions with atypia are a spectra of diseases that confer increased risk of breast cancer because of an increased probability of finding concomitant cancer after excision, or evolution toward in situ or invasive cancer over the long term. The widespread use of radiologic tools and core needle breast biopsies, in recent years, has led to an increase in the diagnosis of these atypical breast lesions. Concurrent with this has been an improvement in the classification and pathogenesis of these lesions. Current evidence suggests that the recognition and treatment of patients with atypical histology after biopsy and surgical excision requires a multidisciplinary approach to decrease the overdiagnosis and overtreatment risks. This focused review investigates the controversy and current management of atypical ductal hyperplasia, lobular neoplasia, flat epithelial atypia, and intraductal papilloma with atypia along with the risk-reducing strategies. [ABSTRACT FROM AUTHOR]
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- 2020
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12. Thyroid disease in the perimenopause and postmenopause period
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Uygur, M. M., primary, Yoldemir, T., additional, and Yavuz, D. G., additional
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- 2018
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13. Surgical challenges in the treatment of perimenopausal and postmenopausal endometriosis
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Ozyurek, E. S., primary, Yoldemir, T., additional, and Kalkan, U., additional
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- 2018
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14. Native tissue repair versus mesh repair in pelvic organ prolapse surgery
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Kalkan, U., primary, Yoldemir, T., additional, Ozyurek, E. S., additional, and Daniilidis, A., additional
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- 2017
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15. P5237The evaluation of ventricular functions by speckle tracking echocardiography in preeclamptic patients
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Tigen, K., primary, Paudel, A., additional, Ozben Sadic, B., additional, Guclu, M., additional, Yoldemir, T., additional, Yildiz, I., additional, Sayar, N., additional, Sari, I., additional, and Basaran, Y., additional
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- 2017
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16. Decreasing bleeding due to uterine fibroid with electroacupuncture
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Akmak, Y.O., Akpnar, I.N., Yoldemir, T., Avdar, S., Akmak, Y.O., Akpnar, I.N., Yoldemir, T., Avdar, S., and Yeditepe Üniversitesi
- Subjects
Fibroid ,menorrhagia ,electroacupuncture ,blood flow ,myoma ,uterine ,female genital diseases and pregnancy complications - Abstract
Objective: To report the usefulness of electroacupuncture (EA) for the management of menorrhagia due to submucous uterine fibroid. Design: Case report. Setting: University hospital. Patient(s): A 48-year-old woman with a symptomatic submucous uterine fibroid, who presented with severe menorrhagia. Intervention(s): Electroacupuncture. Main Outcome Measure(s): Doppler ultrasonographic assessment of uterine blood flow and number of pads used during menorrhagia. Result(s): Doppler ultrasound revealed decreased blood flow of the uterine artery with EA stimulation. With repetitive sessions of EA fewer pads were used during menorrhagia. Conclusion(s): We present the first human case in which decreasing uterine artery blood flow with EA improved menorrhagia due to uterine fibroma. Electroacupuncture could be a useful, alternative, and relatively noninvasive tool for the management of fibroids with menorrhagia as a severe complaint. © 2011 by American Society for Reproductive Medicine.
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- 2011
17. Fertility in midlife women
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Yoldemir, T., primary
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- 2016
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18. Association of serum paraoxonase concentration with serum lipid levels and bone mineral density measurements in early postmenopausal women
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Yoldemir, T., primary and Yavuz, D. G., additional
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- 2014
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19. The association of osteopenia with levels of serum 25-hydroxyvitamin D and HOMA-IR values
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Yoldemir, T., primary and Yavuz, D. G., additional
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- 2013
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20. Fatty necrosis of a mesenteric cyst in a woman initially diagnosed with a large ovarian cystic mass
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Yoldemir, T., primary and Erenus, M., additional
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- 2013
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21. Estrogen receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density
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Yavuz, D. G., primary, Yoldemir, T., additional, Özaltun, K., additional, and Erenus, M., additional
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- 2011
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22. Vitamin D receptor gene polymorphisms in a group of postmenopausal Turkish women: association wıth bone mineral density
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Yoldemir, T., primary, Yavuz, D. G, additional, Anik, G., additional, Verimli, N., additional, and Erenus, M., additional
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- 2011
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23. Should we consider assessment of bone mineral density earlier in postmenopausal women with pelvic organ prolapse?
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Yoldemir, T., primary and Erenus, M., additional
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- 2010
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24. The impact of tibolone and hormone therapy on serum C-reactive protein, tumor necrosis factor-α and hepatocyte growth factor in postmenopausal women
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Sezer Özer, K., primary, Erenus, M., additional, and Yoldemir, T., additional
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- 2009
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25. Excision of a Giant Ovarian Cyst by Open Laparascopy during Late Second Trimester
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Durmusoglu, F., primary, Yoldemir, T., additional, and Yilmaz, C., additional
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- 2008
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26. Association of serum paraoxonase concentration with serum lipid levels and bone mineral density measurements in early postmenopausal women.
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Yoldemir, T. and Yavuz, D. G.
- Subjects
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PARAOXONASE , *SERUM , *DUAL-energy X-ray absorptiometry , *LUMBAR vertebrae , *BONE density - Abstract
Objective To determine the association of serum paraoxonase concentration with serum lipid levels and bone mineral density in early postmenopausal Turkish women. Design One hundred healthy postmenopausal women were included in a cross-sectional study in a University hospital clinic. Blood was drawn from women who had bone mineral density (BMD) measurements during routine visits. BMD of the lumbar vertebrae was measured by dual-energy X-ray absorptiometry. The serum paraoxonase concentration and serum lipid levels were measured. Women were divided into two groups: those with normal lumbar vertebrae BMD and those with osteopenic lumbar vertebrae. Serum paraoxonase concentration was compared between the groups. The correlation between serum paraoxonase concentration and bone mass parameters was performed using Pearson's test. Results The paraoxonase concentration in the osteopenic group was significantly lower than in the group with normal lumbar vertebrae BMD. The paraoxonase concentration was moderately correlated with total cholesterol, low density lipoprotein cholesterol and triglyceride levels among early postmenopausal Turkish women. Conclusions Early postmenopausal women with osteopenic lumbar vertebrae have significantly lower paraoxonase concentration than those with normal lumbar vertebrae BMD. Further studies are needed to clarify the associations between the osteoporosis risk factors and paraoxonase concentration during late postmenopausal years. [ABSTRACT FROM AUTHOR]
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- 2015
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27. Acquired vulvar lymphangiomatosis after cancer therapy
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Gökdemir, G., primary, Kıvanç‐Altunay, İ., additional, and Yoldemir, T., additional
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- 2003
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28. The association of osteopenia with levels of serum 25-hydroxyvitamin D and HOMA-IR values.
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Yoldemir, T. and Yavuz, D. G.
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OSTEOPENIA , *VITAMIN D , *POSTMENOPAUSE , *DUAL-energy X-ray absorptiometry , *GLUCOSE in the body , *INSULIN - Abstract
Objective To determine the association of osteopenia with levels of serum 25-hydroxyvitamin D and HOMA-IR values in postmenopausal women. Methods One hundred healthy postmenopausal women were included in a cross-sectional study. Venous blood was collected after an overnight fast and 25-hydroxyvitamin D, glucose and insulin levels were measured. HOMA-IR was calculated. Bone mineral density was measured with a dual X-ray absorptiometer. Results There was no difference in serum 25-hydroxyvitamin D levels and HOMA-IR values between the two groups. A weak positive correlation between serum 25-hydroxyvitamin D levels and osteopenia was detected. Insulin resistance had a weak negative association with osteopenia. Conclusions The correlations between osteopenia and serum 25-hydroxyvitamin D levels and HOMA-IR values were weak among early postmenopausal women. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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29. Estrogen receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density.
- Author
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Yavuz, D. G., Yoldemir, T., Özaltun, K., and Erenus, M.
- Subjects
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ESTROGEN receptors , *GENETIC polymorphisms , *WOMEN , *POSTMENOPAUSE , *BONE density - Abstract
Objective To evaluate the frequency of the estrogen receptor (ER) gene PvuII and XbaI polymorphisms and their associations with bone mineral density (BMD) in a group of postmenopausal Turkish women. Design A total of 125 healthy postmenopausal women and 125 premenopausal healthy young women as controls were included in the study. The PvuII and XbaI polymorphisms in the ER gene were studied by the polymerase chain reaction-restriction fragment length polymorphism method. The BMD of the lumbar vertebrae and femoral neck were measured by dual-energy X-ray absorptiometry. Results The frequencies of the ERα PVuII genotypes PP, Pp and pp were 20%, 54.4% and 25.6% in premenopausal and 24.8%, 44.8% and 30.4% in postmenopausal women, respectively. The frequencies of the ER XbaI genotypes XX, Xx, xx were 16.8%, 48.8% and 34.4% in premenopausal and 16.8%, 48% and 35.2% in postmenopausal women, respectively. There was no difference in the frequencies of ER gene polymorphisms between premenopausal and postmenopausal women. BMD measurements were not different between ER PvuII and XbaI genotypes in premenopausal and postmenopausal women. Conclusions ER gene PvuII and XbaI polymorphisms have no major influence on bone mineral density in our group of postmenopausal women. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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30. Should we consider assessment of bone mineral density earlier in postmenopausal women with pelvic organ prolapse?
- Author
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Yoldemir, T. and Erenus, M.
- Subjects
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BONE density , *POSTMENOPAUSE , *PELVIC organ prolapse , *OSTEOPENIA , *OSTEOPOROSIS in women - Abstract
Objective To investigate a possible association between the presence of pelvic organ prolapse and osteopenia or osteoporosis in early postmenopausal women. Design Eighty-seven postmenopausal women between the ages of 55 and 60 years who had been admitted to the Gynecology or Menopause Outpatient clinics of Marmara University, School of Medicine were included in the study. Quantification of pelvic organ prolapse was performed for each patient. The bone mineral density measurements of the lumbar vertebrae by dual-energy X-ray absorptiometry were compared between the groups with and without pelvic organ prolapse. Results The mean T-scores for the lumbar area for women with or without pelvic organ prolapse were comparable between the study groups. Conclusions It appears that presence of pelvic organ prolapse in early postmenopausal women is not helpful in predicting osteoporosis. [ABSTRACT FROM AUTHOR]
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- 2011
- Full Text
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31. The impact of tibolone and hormone therapy on serum C-reactive protein, tumor necrosis factor-alpha and hepatocyte growth factor in postmenopausal women.
- Author
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Sezer Ozer K, Erenus M, and Yoldemir T
- Published
- 2009
- Full Text
- View/download PDF
32. Evaluation and management of endometriosis
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T. Yoldemir and Yoldemir T.
- Subjects
malignant transformation ,postmenopausal endometriosis ,endometriosis recurrence ,Endometriosis ,Obstetrics and Gynecology ,pelvic pain ,General Medicine ,infertility - Abstract
The initial diagnostic investigations for endometriosis are physical examination and pelvic ultrasound. The pelvic examination should include a speculum examination and vaginal palpation. Mobility, fixation and/or tenderness of the uterus and site-specific tenderness in the pelvis should be evaluated. Transvaginal ultrasound and pelvic magnetic resonance imaging are recommended to evaluate the extent of the endometriosis and to determine whether any urinary tract or bowel procedures might also be required during surgical resection. Quality of life should be assessed by using the Endometriosis Health Profile-30, its short version EHP-5 or the generic quality of life questionnaire SF- 36. Management of endometriosis is recommended when it has a functional impact (pain, infertility) or causes organ dysfunction. Many gynecological societies have published different guidelines for the evaluation and management of endometriosis. However, the complexity of this disease together with the different available treatments lead to significant discrepancies between the recommendations. Postmenopausal endometriosis should be considered when a patient has a history of symptoms before menopause including dysmenorrhea, dyspareunia, dyschezia, infertility and chronic pelvic pain. Malignant transformation of endometriosis is estimated to occur in about 0.7–1.6% of women affected by endometriosis. Endometriosis is associated with an increased risk of ovarian cancer, specifically clear cell, endometrioid and low-grade serous types.
- Published
- 2023
33. Telemedicine and women’s health
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Tevfik Yoldemir and Yoldemir T.
- Subjects
Klinik Tıp ,Obstetrics and Gynecology ,General Medicine ,OBSTETRICS & GYNECOLOGY ,CLINICAL MEDICINE ,Sağlık Bilimleri ,Doğum ve Jinekoloji ,Kadın Hastalıkları ve Doğum ,Clinical Medicine (MED) ,Telemedicine ,Tıp ,KADIN HASTALIKLARI & DOĞUM ,Surgery Medicine Sciences ,Cerrahi Tıp Bilimleri ,Health Sciences ,Medicine ,Humans ,Women's Health ,Klinik Tıp (MED) ,Female - Published
- 2022
34. The Effect of Prolongated Time to Achieve Ovarian Suppression Before Start of Stimulation on Pregnancy Rates in ART Cycles
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Tevfik Yoldemir and YOLDEMİR T.
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Gynecology ,medicine.medical_specialty ,Pregnancy ,Klinik Tıp ,business.industry ,Stimulation ,CLINICAL MEDICINE ,medicine.disease ,Clinical Medicine (MED) ,Extended protocol ,Ovarian suppression ,TIP, GENEL & DAHİLİ ,GnRHa ,Medicine ,Klinik Tıp (MED) ,business ,MEDICINE, GENERAL & INTERNAL ,ART - Abstract
Amaç: Stimulasyona başlamadan önce ovaryen süpresyonun uzamasının gebelik oranlarına etkisini araştırmak Hastalar ve Yöntem: Üniversite affiliye hastanede yardımcı üreme tetkikleri (assisted reproductive technologies (ART)) tedavileri yapılan 565 hasta retrospektif olarak incelendi. Kadınlar gonadotropin salgılayan hormon (gonadotropin releasing hormone (GnRH)) analogu ile ovaryen süpresyon süresine göre gruplandırıldı. GnRH analog kullanım süresine göre grup A alt 25 persentil içinde, grup B de üst 25 persentil içindeki hastalardan oluşmaktaydı. İmplantasyon ve klinik gebelik oranları karşılaştırıldı. Bulgular: Grup Ada ortalama aspire edilen ve insemine edilen oosit sayısı grup Bdekinden fazla idi. İmplantasyon oranları benzer idi. Klinik gebelik oranları benzer idi. Sonuç: Ovaryen süpresyon için geçen zamanın uzaması ART sikluslarında klinik gebelik oranlarını olumsuz etkilemez. Objective: To determine if the prolonged time for achieving ovarian suppression before starting stimulation affected the pregnancy rates. Patients and Methods: Retrospective cohort analysis was performed on 565 women undergoing first assisted reproductive technologies (ART) treatment in a University-affiliated Hospital. The women were grouped according to the duration of down- regulation by gonadotropin-releasing hormone (GnRH) analogue. Group A consisted of women in the lower 25th percentile, group B consisted of women in the upper 25th percentile, according to the duration of GnRH analogue use. The implantation and clinical pregnancy rates were compared. Results: Mean number of aspirated and inseminated oocytes were more in group A than in group B. Implantation rates were similar. Clinical pregnancy rates were alike. Conclusion: Prolonged time for achieving ovarian supression does not compromise clinical pregnancy rates in ART cycles.
- Published
- 2013
35. Siklusun 3. günü normal FSH değeri olan kadınlarda FSH/LH oranı ICSI başarısını öngörebilir mi
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YOLDEMİR, AHMET TEVFİK and YOLDEMİR T., ERENUS M.
- Subjects
FSH/LH oranı ,TIP, GENEL & DAHİLİ ,Cancellation ,Klinik Tıp ,Pregnancy ,İptal ,Klinik Tıp (MED) ,FSH/LH ratio ,CLINICAL MEDICINE ,MEDICINE, GENERAL & INTERNAL ,ICSI ,Clinical Medicine (MED) ,Gebelik - Abstract
Amaç: Siklusun 3.günü normal FSH değeri olan kadınlarda follikül stimule edici hormon (FSH)/luteinize edici hormon (LH) oranının sitoplazma içi sperm enjeksiyonu (ICSI) başarısının öngörülebilirliğini araştırmak. Hastalar ve Yöntem: Uzun protokol ve rekombinant folikül stimüle edici hormon kullanılarak ICSI tedavisi alan ardışık yüz doksan dokuz infertil kadın retrospektif olarak analiz edildi. Grup A, B, C ve D sırasıyla FSH/LH oranları 2 olan kadınlardan oluşturuldu. Transfer başına klinik gebelik ve implantasyon oranları karşılaştırıldı. Bulgular: Transfer başına klinik gebelik ve implantasyon oranları gruplar arasında benzer idi. Sonuç: Siklusun 3.günü FSH/LH oranı ICSI sikluslarında tedavi sonuçlarını normal 3. gün FSH seviyesi olan kadınlarda öngöremez. Objective: To determine whether the follicule stimulating hormone (FSH)/ luteinizing hormone (LH) ratios on the third day of the cycle predict intracytoplasmic sperm injection (ICSI) outcomes in women with normal day 3 FSH levels. Patients and Methods: A retrospective cohort analysis of one hundred and ninety-nine consecutive women undergoing ICSI treatment with long-down regulation and recombinant follicular stimulating hormone injections was carried out in a University hospital. Four groups were compared in terms of in vitro fertilization (IVF) outcomes. Groups A, B, C and D consisted of women with FSH/LH ratios of 2, respectively. The clinical pregnancy and implantation rates per transfer were compared. Results: There was no significant difference between the groups regarding the clinical pregnancy or implantation rates per transfer. Conclusion: It appears that the basal FSH/LH ratio does not predict the cycle outcome in ICSI cycles in women with normal day 3 FSH levels.
- Published
- 2012
36. The association between female sexual function and metabolic features of the polycystic ovary syndrome in Turkish women of reproductive age.
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Cevik Dogan M and Yoldemir T
- Subjects
- Humans, Female, Adult, Cross-Sectional Studies, Turkey epidemiology, Young Adult, Insulin Resistance physiology, Sexual Dysfunction, Physiological epidemiology, Sexual Dysfunction, Physiological blood, Sexual Dysfunction, Physiological etiology, Testosterone blood, Surveys and Questionnaires, Case-Control Studies, Hyperandrogenism blood, Hyperandrogenism epidemiology, Sexual Behavior physiology, Androstenedione blood, Dehydroepiandrosterone Sulfate blood, Obesity epidemiology, Obesity metabolism, Obesity blood, Polycystic Ovary Syndrome blood, Polycystic Ovary Syndrome metabolism
- Abstract
Objective: To investigate the association between female sexual function and metabolic features among women with polycystic ovary syndrome (PCOS) during reproductive age., Method: This was a cross-sectional study in which 288 women with PCOS and 180 women without PCOS between the ages of 20 and 40 years were evaluated. All women had serum total testosterone, androstenedione, DHEA-S, fasting glucose, total cholesterol, HDL-C, LDL-C, and triglyceride levels analyzed. The McCoy Female Sexual Questionnaire (MFSQ) was applied to all studied women. Exploratory factor analysis and reliability analysis were done after data collection. The factor loadings of MFSQ domains were compared between women with PCOS and controls., Results: Average factor loadings of the MFSQ sexuality domain and MFSQ sexual partner domain were significantly lower in the PCOS group when compared to controls. There was no correlation between the two sexual function domains of the MFSQ and the PCOS features either in the PCOS group or the controls., Conclusion: PCOS is a heterogeneous disease with different metabolic components, such as insulin resistance, obesity, and hyperandrogenism. Although sexual function among women with PCOS was lower than controls, no differences were found in metabolic features of the PCOS and non-PCOS groups with relation to sexual function determined by the MFSQ.
- Published
- 2024
- Full Text
- View/download PDF
37. Comparison of anxiety scores between unexplained primary and secondary infertile couples.
- Author
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Yoldemir T, Yassa M, and Atasayan K
- Subjects
- Adult, Case-Control Studies, Female, Humans, Male, Anxiety, Infertility psychology
- Abstract
Objective: To investigate the anxiety levels among infertile women and their partners also factors that may affect the anxiety status., Study Design: A total of 403 infertile couples who applied to Infertility Outpatient Clinics of a University-affiliated Teaching and Research Hospital were included in the study. The infertile group was divided into two groups as primary and secondary infertile. One hundred and thirty-two fertile couples who applied to Gynecology Outpatient Clinics composed the control group. Hamilton Anxiety Rating Scale (HAM-A) form was filled by the infertile couples to evaluate the anxiety status before they started their treatment., Results: Three hundred and twenty infertile and 84 fertile couples completed the study. The mean total scores of HAM-A of women were similar between the groups. So were the scores of their husbands. In all groups, women had significantly higher mean total HAM-A scores than their husbands. There was no association between the mean HAM-A score of women and age, BMI, AFC, duration of marriage, duration of infertility, number of previous treatment cycles. Education status, working status and family structure of women did not correlate with the mean HAM-A score., Conclusion: Unexplained primary and secondary infertile couples had similar anxiety scores before the commencement of fertility treatments. However, the scores were higher in women than their male partners. Since the burden of treatment and the likelihood of treatment failure might increase the level of anxiety the women could be offered proper cognitive coping and relaxation interventions.
- Published
- 2021
- Full Text
- View/download PDF
38. The effects of progesterone treatment on nuchal translucency in women with threatened miscarriage.
- Author
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Karadağ C, Yoldemir T, Demircan S, and Çalışkan E
- Subjects
- Administration, Oral, Adult, Chorionic Gonadotropin, beta Subunit, Human blood, Crown-Rump Length, Female, Humans, Pregnancy, Pregnancy Trimesters blood, Pregnancy-Associated Plasma Protein-A analysis, Treatment Outcome, Abortion, Threatened drug therapy, Nuchal Translucency Measurement drug effects, Pregnancy Trimesters drug effects, Progesterone administration & dosage, Progestins administration & dosage
- Abstract
This study aims to investigate the effects of progesterone on the possible changes in nuchal translucency (NT) levels for patients diagnosed with threatened miscarriage. The study group was composed of 125 patients diagnosed with threatened miscarriage and taking 400 mg/day micronized orally progesterone at least for two weeks, the control group was composed of 160 healthy pregnant women not taking any progesterone. Crown rump length (CRL) NT thickness, Pregnancy-associated plasma protein-A (PAPP-A), free beta human chorionic gonadotropin (Beta-HCG) levels of patients were measured for assessment of aneuploidy risk. Both of the groups were divided into four subgroups to determine the relationship between thickness of NT and progesterone use for specific CRL measurements. CRL in the first, second, third and fourth group was 45-55 mm, 55-65 mm, 65-75 mm, 75-84 mm, respectively. The two groups were age and BMI matched. In all groups of CRL there were no significant difference in Mom levels of NT thickness, PAPP-A and free Beta-HCG between the study and control groups. There havent been any relation between NT thickness and progesterone use.IMPACT STATEMENT What is already known about this subject? Recently some studies have claimed that progesterone use might have caused atypical blood flow pattern on foetal circulation, which could possibly increase NT. If the NT thickness is affected by the use of progesterone, then the false positive rate of detecting Down Syndrome screening tests would increase. What the results of this study add? In this study we did not found any relation between NT thickness and progesterone use. What the implications are of these findings for clinical practice and/or further research? Using orally progesterone due to threatened miscarriage do not change NT thickness levels. Further studies have to be done with a large number of participants.
- Published
- 2021
- Full Text
- View/download PDF
39. The effect of PCOS status on atherosclerosis markers and cardiovascular disease risk factors in young women with vitamin D deficiency.
- Author
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Atasayan K and Yoldemir T
- Subjects
- Adolescent, Adult, Atherosclerosis blood, Atherosclerosis epidemiology, Atherosclerosis etiology, Biomarkers blood, Cardiovascular Diseases blood, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology, Carotid Intima-Media Thickness, Case-Control Studies, Female, Humans, Risk Factors, Turkey epidemiology, Young Adult, Heart Disease Risk Factors, Polycystic Ovary Syndrome blood, Polycystic Ovary Syndrome complications, Polycystic Ovary Syndrome epidemiology, Vitamin D Deficiency blood, Vitamin D Deficiency complications, Vitamin D Deficiency epidemiology
- Abstract
Objective: To investigate whether polycystic ovary syndrome (PCOS) had further deteriorating influence on endothelial function or cardiometabolic parameters in women with vitamin D deficiency during reproductive age., Study Design: The study group was composed of women with PCOS and vitamin D deficiency and insufficiency between the ages of 18 and 35 years. Age and body mass index (BMI)-matched women were chosen as controls. Serum 25(OH) Vit D levels below 20 ng/mL were considered as vitamin D deficiency. The cutoff level of vitamin D insufficiency was suggested at 30 ng/mL. Serum FSH, LH, estradiol, testosterone, DHEA-S, fasting glucose, total cholesterol, HDL, LDL, triglyceride levels were analyzed. Carotid artery intima-media thickness (CIMT) was measured, and the flow-mediated vasodilation (FMD) was calculated., Results: CIMT and FMD values in both vitamin D deficiency and insufficiency subgroups showed no significant difference between PCOS and non-PCOS groups. There was a weak negative correlation between BMI, waist/hip ratio, CRP, and 25(OH) Vitamin D., Conclusion: PCOS is a heterogeneous disease with different combinations of the diagnostic components. Vitamin D is an important variable for a healthy cardiovascular system. We did not find any difference in early atherosclerotic markers and cardiometabolic features between PCOS and non-PCOS group with Vitamin D deficiency.
- Published
- 2021
- Full Text
- View/download PDF
40. Comparison of depression between primary and secondary infertile couples.
- Author
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Yoldemir T, Yassa M, and Atasayan K
- Subjects
- Adult, Case-Control Studies, Depression epidemiology, Depressive Disorder epidemiology, Female, Humans, Male, Turkey epidemiology, Young Adult, Depression psychology, Depressive Disorder psychology, Infertility, Female psychology, Infertility, Male psychology, Parity
- Abstract
Objective: We aimed to compare the depression levels between primary and secondary infertile couples and to investigate the related factors that may affect depression., Study Design: Two hundred and fifty primary and secondary infertile couples, who admitted to Gynecology and Infertility Clinics of Pendik Teaching and Research Hospital affiliated with Marmara University were enrolled in this study. Sixty-four BMI-matched fertile female patients who applied to the General Gynecology Clinic and their husbands were taken as the control group. Beck Depression Inventory (BDI) form was filled by the infertile couples to evaluate the depression status before they started their cycles., Results: The mean total BDI scores were alike between groups among women. Mild depression was found to be higher in the primary infertile women and moderate depression was higher in women of the control group. Women had statistically higher depression scores than male partners. Primary infertile, secondary infertile, and fertile women had higher depression scores than their male partners in the corresponding groups. There was no significant difference in mean total BDI scores among males between the groups. The percentage of distribution of male partners in each level of depression was similar between the groups., Conclusions: Only a weak positive correlation between the mean total BDI score and the number of previous treatment cycles was found. Psychiatric support before and during the upcoming fertility treatment might reduce the perception of the probable treatment failure.
- Published
- 2020
- Full Text
- View/download PDF
41. Internet Of Things and women's health.
- Author
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Yoldemir T
- Subjects
- Female, Humans, Internet of Things, Women's Health trends
- Published
- 2020
- Full Text
- View/download PDF
42. The evaluation of ventricular functions by speckle tracking echocardiography in preeclamptic patients.
- Author
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Paudel A, Tigen K, Yoldemir T, Guclu M, Yildiz I, Cincin A, Sunbul M, Gurel E, Sayar N, and Ozben B
- Subjects
- Adult, Case-Control Studies, Female, Gestational Age, Humans, Postpartum Period, Pre-Eclampsia physiopathology, Predictive Value of Tests, Pregnancy, Recovery of Function, Time Factors, Young Adult, Echocardiography, Doppler, Color, Pre-Eclampsia diagnostic imaging, Ventricular Function, Left, Ventricular Function, Right
- Abstract
Preeclampsia is a maternal disorder of pregnancy characterized by concomitant increase in preload and afterload with end organ dysfunction. The aim of our study is to evaluate left ventricular (LV) and right ventricular (RV) functions with speckle tracking echocardiography in preeclamptic patients. Fifty-five preeclamptic (mean age: 30.7 ± 5.9 years) and 35 healthy pregnant women (mean age: 28.8 ± 5.7 years) of the same race, similar age and gestational week were consecutively included. The diagnosis of preeclampsia was based on the criteria proposed by the American College of Obstetricians and Gynecologists. LV and RV functions were assessed by both conventional and speckle tracking echocardiography after the 30th gestational week and at the postpartum 6th months. The preeclamptic patients had significantly larger left atrium, thicker interventricular septum, higher systolic pulmonary artery pressure and mitral E/e' ratio compared to controls during pregnancy while LV ejection fraction was similar. Preeclamptic patients had significantly lower LV and RV global longitudinal strain (GLS) during pregnancy compared to controls (- 18.0 ± 2.6% vs. - 19.8 ± 2.1% p = 0.001 and - 26.7 ± 3.3% vs. 28.9 ± 3.3% p = 0.002, respectively). In the postpartum period, while LVGLS values of preeclamptic patients increased significantly (- 18.0 ± 2.6% vs. - 20.4 ± 2.4% p < 0.001) and became similar to those of controls at the sixth month, the RVGLS decreased significantly (- 26.7 ± 3.3% vs. - 25.8 ± 2.7% p = 0.003) making the difference in RVGLS between the preeclamptic patients and controls more prominent. Preeclampsia may impair LV and RV function. Long-term follow up with larger sample is needed to determine the clinical relevance of the observed changes in strain.
- Published
- 2020
- Full Text
- View/download PDF
43. Adenomyosis and fertility outcomes.
- Author
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Yoldemir T
- Subjects
- Adenomyosis complications, Adenomyosis epidemiology, Adult, Embryo Transfer methods, Female, Fertility Preservation methods, Gonadotropin-Releasing Hormone analogs & derivatives, Gonadotropin-Releasing Hormone therapeutic use, Humans, Infertility, Female diagnosis, Infertility, Female epidemiology, Infertility, Female etiology, Infertility, Female therapy, Middle Aged, Organ Sparing Treatments methods, Ovarian Reserve physiology, Postoperative Complications epidemiology, Postoperative Complications etiology, Postoperative Complications prevention & control, Postoperative Complications therapy, Pregnancy, Pregnancy Rate, Prognosis, Reproductive Techniques, Assisted, Treatment Outcome, Adenomyosis diagnosis, Adenomyosis therapy, Fertility physiology
- Published
- 2020
- Full Text
- View/download PDF
44. The effects of endometrioma size and bilaterality on ovarian reserve.
- Author
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Karadağ C, Yoldemir T, Demircan Karadağ S, and Turgut A
- Subjects
- Adult, Correlation of Data, Female, Humans, Infertility, Female diagnosis, Infertility, Female etiology, Infertility, Female prevention & control, Organ Size, Ovarian Follicle, Ultrasonography methods, Anti-Mullerian Hormone blood, Endometriosis blood, Endometriosis complications, Endometriosis diagnosis, Endometriosis surgery, Laparoscopy adverse effects, Laparoscopy methods, Ovarian Cysts blood, Ovarian Cysts complications, Ovarian Cysts diagnosis, Ovarian Cysts surgery, Ovarian Reserve, Ovary diagnostic imaging, Ovary pathology, Ovary physiopathology
- Abstract
The aim of this study was to investigate the effects of endometrioma (OMAs) size and bilaterality on ovarian reserve. The patients with OMA were determined by ultrasonographic examination. Fifty patients with unilateral OMA (Group A), 30 patients with bilateral OMA (Group B), and 60 women without ovarian cysts (Group C) were included in this study. AMH levels were measured, and antral follicle count (AFC) was determined. The mean serum AMH levels were significantly lower in Group B than Groups C and A, and were significantly lower in Group A than Group C. There was a significant correlation between serum AMH level and OMA size in Group A ( R = -.372, p = .008). OMAs per se appear to be associated with damage to the ovarian reserve. Increased OMA size is related to decreased AMH levels in patients with OMA. Bilateral OMAs have a more destructive effect on ovarian reserve.IMPACT STATEMENT What is already known on this subject? Previous Studies have demonstrated the effect of surgery on ovarian reserve but there have been contradictory findings reported about the effects of OMAs per se on serum AMH levels and it has not been clear what the relation between OMAs size and AMH levels is, if any. What the results of this study add? In this study, we found decreased AMH levels in patients with OMA. The results showed significant negative correlation between OMA size and AMH levels. The patients with bilateral OMAs had lower AMH levels than the unilateral ones. What the implications are of these findings for clinical practice and/or further research? Increasing OMA size might be harmful to ovarian reserve. Further studies should be done to evaluate whether increasing the size of the OMA is associated with a progressive decline in ovarian reserve and to better clarify the role of the OMAs per se or of laparoscopic surgery in the determination of damage to the ovarian reserve.
- Published
- 2020
- Full Text
- View/download PDF
45. Artificial intelligence and women's health.
- Author
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Yoldemir T
- Subjects
- Female, Humans, Risk Assessment, Artificial Intelligence, Women's Health
- Published
- 2020
- Full Text
- View/download PDF
46. Relation of NT-probnp levels and cardiovascular disease risk factors in lean women with polycystic ovary syndrome.
- Author
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Karadağ C and Yoldemir T
- Subjects
- Adult, C-Reactive Protein, Cholesterol blood, Female, Humans, Insulin Resistance, Risk Factors, Testosterone blood, Body Mass Index, Cardiovascular Diseases blood, Natriuretic Peptide, Brain blood, Peptide Fragments blood, Polycystic Ovary Syndrome blood
- Abstract
Women with polycystic ovary syndrome (PCOS) often have cardiovascular disease (CVD) risk factors. N-terminal fragment of brain natriuretic peptide (Nt-probnp) is used as a diagnostic and prognostic marker for CVD. The aim of this study was to evaluate whether Nt-probnp is increased in lean PCOS patients. A total of 110 lean (BMI < 25 kg/m
2 ) PCOS patients and 80 age and BMI matched healthy lean controls were included in this study. Serum Homeostatic Model Assessment-Insulin Resistance (HOMA-IR), Matsuda insulin sensitivity index (ISI), Nt-probnp, C-reactive protein (CRP), androgen and lipid levels were measured. Serum Nt-probnp levels were significantly higher in the PCOS group. Hyperandrogenic PCOS patients had higher Nt-probnp levels. There were significant correlations between serum Nt-probnp and total testosterone, total cholesterol, HOMA and Matsuda levels. Linear regression analysis showed that Matsuda ISI and fasting insulin levels significantly affected the Nt-probnp levels ( R2 of the model = 0.763; p <.0001). IMPACT STATEMENT What is already known on this subject? Many risk factors for cardiovascular disease (CVD) including insulin resistance, dyslipidaemia, hypertension and hyperandrogenism may be found in young women with polycystic ovary syndrome (PCOS), although evidence for CVD in lean women with PCOS is limited. N-terminal fragment of brain natriuretic peptide (NT-probnp) is a high predictive marker regarding of CVD, especially in patients without overt CVD. There have been contradictory results regarding Nt-probnp levels in PCOS patients and there have not been any effective studies regarding the relation between CVD risk factors and Nt-probnp levels for lean PCOS patients. What the results of this study add? This study found increased Nt-probnp levels in lean PCOS patients, which may indicate a positive correlation with risk for CVD. Strong relations were also found between Nt-probnp levels and increased insulin resistance, dyslipidaemia, decreased insulin sensitivity and hyperandrogenism. Lean PCOS patients have increased risk factors for CVD, and these risk factors are correlated with Nt-probnp levels. Nt-probnp is more affected by increased fasting insulin and decreased insulin sensitivity. What the implications are of these findings for clinical practice and/or further research? Lean PCOS patients should be evaluated for CVD. Further prospective controlled studies are needed in order to predict the long-term risk of developing CVD in lean PCOS patients.- Published
- 2019
- Full Text
- View/download PDF
47. Quality of life among infertile PCOS patients.
- Author
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Angin P, Yoldemir T, and Atasayan K
- Subjects
- Adult, Female, Humans, Surveys and Questionnaires, Young Adult, Infertility, Female parasitology, Infertility, Female psychology, Polycystic Ovary Syndrome complications, Polycystic Ovary Syndrome psychology, Quality of Life psychology
- Abstract
Objective: To investigate whether quality of life differs between PCOS and non-PCOS infertile women., Study Design: Two questionnaire forms of quality of life (PCOSQ, SF-36) were given to 238 women. Patients were asked to answer all of the questions in both of the questionnaires. Of these 238 women, only 49 infertile PCOS patients, 47 infertile non-PCOS patients and 62 fertile PCOS patients fılled the forms completely., Results: Both PCOSQ and SF-36 scores are lowest in infertile PCOS group. Although total PCOSQ score of infertile non-PCOS group was better than non-infertile PCOS and fertile PCOS groups; there was trend for lower scores when infertility is added on PCOS status., Conclusion: The quality of life is lowest among infertile PCOS women. Both PCOS and infertility as individual factors may have negative impact in quality of life of reproductive age women.
- Published
- 2019
- Full Text
- View/download PDF
48. Delayed cord clamping in term large-for-gestational age infants: A prospective randomised study.
- Author
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Vural I, Ozdemir H, Teker G, Yoldemir T, Bilgen H, and Ozek E
- Subjects
- Apgar Score, Constriction, Female, Follow-Up Studies, Gestational Age, Hospitals, University, Humans, Infant, Newborn, Infant, Newborn, Diseases physiopathology, Male, Prospective Studies, Statistics, Nonparametric, Time Factors, Turkey, Ultrasonography, Prenatal methods, Fetal Macrosomia diagnosis, Infant, Newborn, Diseases etiology, Term Birth, Time-to-Treatment, Umbilical Cord surgery
- Abstract
Aim: To compare the post-natal effects of delayed cord clamping (DCC) and early cord clamping (ECC) in term large-for-gestational age (LGA) infants., Methods: This prospective randomised study included 51 term LGA infants. The umbilical cords of these infants were clamped at 15 s in group 1 (ECC group (n = 26)) and at 60 s in group 2 (DCC group (n = 25)). Data for Apgar scores, cord blood, pH and lactate values, second haematocrit, 24th bilirubin levels, duration of hospital stay and admission to the neonatal intensive care unit (NICU) were recorded., Results: The demographic characteristics of the infants in the study group were not significantly different. No statistically significant difference was observed in the post-natal haematocrit and bilirubin levels between the groups. Six infants (group 1, n = 3; group 2, n = 3) were diagnosed with polycythaemia (P = 0.79); however, these infants remained asymptomatic, and no treatment was required. One infant in each group developed hyperbilirubinemia, which required phototherapy (P = 1.00). The infant with hyperbilirubinemia in the DCC group presented with asymptomatic polycythaemia. Three neonates in the DCC group required admission to the NICU for transient tachypnoea., Conclusions: No significant increase in the rate of post-natal complications of DCC in term LGA infants was observed in the study. However, before recommending DCC on a routine basis, studies with a larger sample size and long-term follow-up are required to elucidate the risks and benefits of DCC in this group of infants., (© 2018 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).)
- Published
- 2019
- Full Text
- View/download PDF
49. Quality of life for women with endometriosis: premenopausal and postmenopausal perspectives.
- Author
-
Yoldemir T
- Subjects
- Endometriosis psychology, Female, Humans, Endometriosis physiopathology, Postmenopause, Premenopause, Quality of Life
- Published
- 2018
- Full Text
- View/download PDF
50. Effects of vitamin D supplementation on insulin sensitivity and androgen levels in vitamin-D-deficient polycystic ovary syndrome patients.
- Author
-
Karadağ C, Yoldemir T, and Yavuz DG
- Subjects
- Adolescent, Adult, Androstenedione blood, Blood Glucose, Body Mass Index, Dietary Supplements, Female, Humans, Polycystic Ovary Syndrome complications, Prospective Studies, Testosterone blood, Vitamin D analogs & derivatives, Vitamin D Deficiency complications, Vitamin D Deficiency drug therapy, Young Adult, Cholecalciferol therapeutic use, Insulin Resistance physiology, Polycystic Ovary Syndrome blood, Vitamin D Deficiency blood
- Abstract
Aim: The aim of this study was to identify the effects of vitamin D supplementation on insulin sensitivity and androgen levels in vitamin-D-deficient polycystic ovary syndrome (PCOS) patients., Methods: Sixty-seven vitamin-D-deficient (25-hydroxyvitamin D [25(OH)D] levels below 20 ng/mL) PCOS patients and 54 vitamin-D-deficient non-PCOS volunteer subjects matched for age and body mass index were enrolled to this prospective study. All participants were given 50 000 IU/week cholecalciferol orally for 8 weeks and 1500 IU/day for 4 weeks. Insulin sensitivity was calculated with the Matsuda insulin sensitivity index (ISI) based on an oral glucose tolerance test. Matsuda ISI, gonadal hormones (estrogen, testosterone, androstenedione), and 25(OH)D levels were studied before and at the end of the 12th week of vitamin D load., Results: After vitamin D supplementation, serum androstenedione levels had decreased significantly (P = 0.007) and Matsuda ISI values had increased significantly (P = 0.001) in the PCOS group but no significant changes were seen in those parameters in controls. We observed positive correlations between 25(OH)D levels and Matsuda ISI (r = 0.307; P < 0.01), and negative correlations between 25(OH)D levels and total testosterone (r = -0.306; P < 0.01) and androstenedione (r = -0.275; P < 0.01) levels in the PCOS group., Conclusion: Vitamin D supplementation increased insulin sensitivity and decreased androgen levels in vitamin-D-deficient women with PCOS but did not have any effect in vitamin-D-deficient non-PCOS women. These results may indicate the possible role of vitamin D in the complex pathogenesis of PCOS., (© 2017 Japan Society of Obstetrics and Gynecology.)
- Published
- 2018
- Full Text
- View/download PDF
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