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625 results on '"Yokochi T"'

22. Techniques for Characterization of Leucocyte Antigens and Utilization of Antibodies in Therapy

Author

Avnstrøm, S., Bjerrum, O. J., Wilken, M., Plesner, T., Tinggaard, N., Boyd, A. W., Burns, G. F., Buican, T. N., Hoffmann, G. W., Chatenoud, L., Baudrihaye, M., Goldstein, G., Bach, J. F., Clark, E., Holly, R., Yokochi, T., Feller, A. C., Parwaresch, M. R., Wacker, H. H., Lennert, K., Hofman, F. M., Yanagihara, E., Byrne, B. A., Billing, R., Baird, S., Frisman, D., Taylor, C. R., Jansen, F. K., Blythman, H., Carrière, D., Casellas, P., Hellström, I., Hellström, K. E., Gros, O., Gros, P., Laurent, J. C., Poncelet, Ph., Richer, G., Royston, I., Vidal, H., Voisin, G., Kieda, C., Monsigny, M., Waxdal, M., Kurrle, R., Lang, W., Kanzy, E. J., Hofstaetter, Th., Seiler, F. R., Matejić, T., Terzić, G., Isaković, K., Janković, B. D., Radzun, H. J., Spring, F., Anstee, D., Stein, H., Gerdes, J., Schwab, U., Lemke, H., Tabilio, A., Vainchenker, W., Testa, U., Vinci, G., Guichard, J., Vernant, J. P., Mannoni, P., Breton-Gorius, J., Teodorescu, M., Ralapati, S., van Es, A., Tanke, H. J., Baldwin, W. M., III, Oljans, P. J., Ploem, J. S., van Es, L. A., Bernard, Alain, editor, Boumsell, Laurence, editor, Dausset, Jean, editor, Milstein, César, editor, and Schlossman, Stuart F., editor

Published
1984
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27. Premature apoptosis of keratinocytes and the dysregulation of keratinization in porokeratosis

Author

Kiyofumi Yamanishi, Goto T, Yokochi T, Shen Cs, Tabata K, and Masato Matsuki

Subjects
Adult, Keratinocytes, Male, Pathology, medicine.medical_specialty, Hyperkeratosis, Down-Regulation, Apoptosis, Dermatology, Biology, Immunoenzyme Techniques, Keratin, medicine, In Situ Nick-End Labeling, Humans, Protein Precursors, Parakeratosis, Involucrin, Aged, chemistry.chemical_classification, Aged, 80 and over, TUNEL assay, integumentary system, Epidermis (botany), Membrane Proteins, Cell Differentiation, Middle Aged, medicine.disease, Porokeratosis, chemistry, Loricrin, Female, medicine.symptom, Epidermis
Abstract

Summary Background Porokeratosis is a dyskeratotic disorder of the skin characterized by cornoid lamella with parakeratosis, hyperkeratosis and loss of granular layers. The pathogenesis of porokeratosis and the mechanism(s) of its abnormal keratinization are still unknown. Objective To elucidate the mechanism(s) of abnormal keratinization that leads to the formation of cornoid lamellae in porokeratosis. Methods Apoptosis of keratinocytes was assessed in the skin of seven patients by an in situ apoptosis assay based on the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labelling (TUNEL) reaction. Patterns of loricrin and involucrin expression were examined by immunohistochemistry. Results TUNEL-positive keratinocytes were observed in the epidermis underlying the cornoid lamella in all cases examined. Furthermore, loricrin expression was interrupted there, in contrast to involucrin, which was expressed diffusely in the lesional epidermis. Conclusions These results suggest that an abnormal early keratinocyte apoptosis accompanied by dysregulation of terminal differentiation of those cells may be involved in the pathogenesis of porokeratosis.

Published
2002

46. Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53

Author

Nozawa, H., primary, Oda, E., additional, Nakao, K., additional, Ishihara, M., additional, Ueda, S., additional, Yokochi, T., additional, Ogasawara, K., additional, Nakatsuru, Y., additional, Shimizu, S., additional, Ohira, Y., additional, Hioki, K., additional, Aizawa, S., additional, Ishikawa, T., additional, Katsuki, M., additional, Muto, T., additional, Taniguchi, T., additional, and Tanaka, N., additional

Published
1999
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