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1. A General Method to Screen Nanobodies for Cytochrome P450 Enzymes from a Yeast Surface Display Library

2. The Versatile Biocatalyst of Cytochrome P450 CYP102A1: Structure, Function, and Engineering

3. Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed CellsSummary

4. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities

5. Heme-binding by Drosophila retinoid- and fatty acid-binding glycoprotein (RFABG), a member of the proapolipophorin gene family

9. Data from Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts

11. Dynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase

12. Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts

13. Hsp70:CHIP Ubiquitinates Dysfunctional but Not Native Neuronal NO Synthase

14. Cryo-EM reveals the architecture of the dimeric cytochrome P450 CYP102A1 enzyme and conformational changes required for redox partner recognition

15. Bronchodilator Reversibility Occurring during the Acute Phase of Paragonimiasis westermani Infection

16. Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed CellsSummary

17. MAPPING PROTEIN-PROTEIN INTERACTIONS IN HOMODIMERIC CYP102A1 BY CROSSLINKING AND MASS SPECTROMETRY

18. Amphipol-facilitated elucidation of the functional tetrameric complex of full-length cytochrome P450 CYP2B4 and NADPH-cytochrome P450 oxidoreductase

19. Chaperone Activity and Dimerization Properties of Hsp90αand Hsp90βin Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery

20. Targeting Hsp70 facilitated protein quality control for treatment of polyglutamine diseases

22. Significant Improvement of Antithrombotic Responses to Clopidogrel by Use of a Novel Conjugate as Revealed in an Arterial Model of Thrombosis

23. The full-length cytochrome P450 enzyme CYP102A1 dimerizes at its reductase domains and has flexible heme domains for efficient catalysis

24. Chaperone Activity and Dimerization Properties of Hsp90

25. Functional characterization of the G162R and D216H genetic variants of human CYP17A1

26. Architecture of the Nitric-oxide Synthase Holoenzyme Reveals Large Conformational Changes and a Calmodulin-driven Release of the FMN Domain

27. Potential Role of Epigenetic Mechanisms in the Regulation of Drug Metabolism and Transport

28. Potent Mechanism-Based Inactivation of Cytochrome P450 2B4 by 9-Ethynylphenanthrene: Implications for Allosteric Modulation of Cytochrome P450 Catalysis

29. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

30. Ubiquitination of Neuronal Nitric-oxide Synthase in the Calmodulin-binding Site Triggers Proteasomal Degradation of the Protein

31. Improved method for assembly of hemeprotein neuronal NO-synthase heterodimers

32. C331A Mutant of Neuronal Nitric-oxide Synthase Is Labilized for Hsp70/CHIP (C Terminus of HSC70-interacting Protein)-dependent Ubiquitination

33. Inhibition of Hsp70 by Methylene Blue Affects Signaling Protein Function and Ubiquitination and Modulates Polyglutamine Protein Degradation

34. Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

35. Cigarette Smoking and Erectile Dysfunction: Focus on NO Bioavailability and ROS Generation

36. Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants

37. Tetrahydrobiopterin Protects against Guanabenz-Mediated Inhibition of Neuronal Nitric-Oxide Synthase in Vitro and in Vivo

38. Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase

39. Metabolism of Aminoguanidine, Diaminoguanidine, and NG-Amino-<scp>l</scp>-arginine by Neuronal NO-Synthase and Covalent Alteration of the Heme Prosthetic Group

40. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities

41. Ubiquitylation of Neuronal Nitric-oxide Synthase by CHIP, a Chaperone-dependent E3 Ligase

42. Ubiquitination and Degradation of Neuronal Nitric-Oxide Synthase in Vitro: Dimer Stabilization Protects the Enzyme from Proteolysis

43. The Hsp90 Cochaperone p23 Is the Limiting Component of the Multiprotein Hsp90/Hsp70-based Chaperone System in Vivo Where It Acts to Stabilize the Client Protein·Hsp90 Complex

44. Proteolytic Degradation of Nitric Oxide Synthase: Effect of Inhibitors and Role of hsp90-Based Chaperones: Figure 1

45. Assembly and activation of heme-deficient neuronal NO synthase with various porphyrins

46. Alteration of the Heme Prosthetic Group of Neuronal Nitric-Oxide Synthase during Inactivation byNG-Amino-l-arginine in Vitro and in Vivo

47. hsp90 Is Required for Heme Binding and Activation of Apo-Neuronal Nitric-oxide Synthase

48. A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases

49. Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases

50. Agmatine Enhances the NADPH Oxidase Activity of Neuronal NO Synthase and Leads to Oxidative Inactivation of the Enzyme

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