Search

This study aims to assess the level of safety, comfort and efficiency between various modes of transportation and the criteria for assessing are integration of payment systems, suitability of schedules, transit facilities, and completeness of information. Each criterion is identified, where these criteria can be measured quantitatively through primary and secondary data collection. In this study, an evaluation of the integration of KRL Commuter line, Airport Train and Transjakarta was carried out which is located at Manggarai Central Station. In this study, the Analytical Hierarchy Process (AHP) method was used to evaluate 4 criteria, with the calculation results showing the order of assessment criteria starting from the highest, namely the payment system with a value of 0.434285562, transit facilities with a value of 0.262313003, schedule suitability with a value of 0, 165718117 and completeness of information with a value of 0.156162323. Based on the results of this assessment, the KRL Commuter line integration service with the Airport and Transjakarta Trains at Manggarai Central Station can be used as a reference for other stations to achieve minimum service standards for intermodal integration.

This article discusses the problems experienced by converts to Islam in Trenceng Hamlet. Many residents of Dukuh Trenceng have embraced Islam but they face many religious problems such as religious facilities and coaching. The purpose of this service is to provide guidance, strengthen religious concepts, practice worship training. As for coaching through the literacy program, there are three programs; regular studies, practical worship practices and learning to read the Al-Quran using the wafa method. This service activity also has a positive impact on the Dukuh Trenceng converts group, which can increase obedience and enthusiasm for worship.

Emerging evidence indicates the potential clinical significance of specific microbial signatures as diagnostic and prognostic biomarkers, in multiple cancers. However, to date, no studies have systematically interrogated circulating metagenome profiling in oesophageal adenocarcinoma (EAC) patients, particularly as novel non-invasive, early detection, surveillance and prognostic classifiers.Metagenome sequencing was performed on 81 serum specimens collected across EAC spectrum, with sequencing reads classified using Bracken and MetaPhlAn3. Followed by the Linear Discriminant Analysis effect size (LEfSe) method to identify microbial profiles between groups. Logistic regression and Kaplan-Meier analyses were used to build classifiers.A significant loss of alpha and beta diversity was identified in serum specimens from EAC patients. We observed a shift in microbial taxa between each group-at the phylum, genus, and species level-with Lactobacillus sakei as the most prominent species in gastroesophageal reflux (GERD) vs other patient groups. Interestingly, LEfSe analysis identified a complete loss of Lactobacillus (L. Sakei and L. Curvatus), Collinsella stercoris and Bacteroides stercoris but conversely a significant increase in Escherichia coli in patients with EAC. Finally, we developed a metagenome panel that discriminated EAC from GERD patients with an AUC value of 0.89 (95% CI: 0.78-0.95; P 0.001) and this panel in conjunction with the TNM stage was a robust predictor of overall survival (≥24 months; AUC = 0.84 (95% CI: 0.66-0.92; P = 0.006)).This study firstly describes unique blood-based microbial profiles in patients across EAC carcinogenesis, that are further utilised to establish a novel circulating diagnostic and prognostic metagenomic signature for EAC.Accumulating data indicates the clinical relevance of specific microbial signatures as diagnostic and prognostic biomarkers, in multiple cancers. However, to date, no studies have systematically interrogated circulating metagenome profiling in patients with oesophageal adenocarcinoma (EAC). Herein, we performed metagenome sequencing in serum specimens from EAC patients 81 collected across EAC spectrum and observed a significant loss of alpha and beta diversity, with a shift in microbial taxa between each group-at the phylum, genus, and species level-with Lactobacillus sakei as the most prominent species in gastroesophageal reflux (GERD) vs other patient groups. Interestingly, LEfSe analysis identified a complete loss of Lactobacillus (L. Sakei and L. Curvatus), Collinsella stercoris and Bacteroides stercoris but conversely a significant increase in Escherichia coli in patients with EAC. Finally, we developed a metagenome panel that discriminated EAC from GERD patients with an AUC value of 0.89 and this panel, in conjunction with the TNM stage, was a robust predictor of overall survival. This study for the first time describes unique blood-based microbial profiles in patients across EAC carcinogenesis, that are further utilised to establish a novel circulating diagnostic and prognostic metagenomic signature for EAC.

In an effort to maintain per capita income in Indonesia, the Government must take action through strengthening national protection. Per capita is the average income of all residents in a country. Per capita income is obtained from the distribution of the national income of a country by the total population of that country. There is a decrease in the population per capita of North Sumatra at the Central Statistics Agency (BPS) in 2020. The author will use the backpropagation algorithm to make a performance. Backpropagation iskone ofkmethodkartificial neural networklquite reliablejinlsolvekproblem. In researchj5 models are usedlarchitecture: 4-15-1, 4-30-1,k4-45-1, 4-60-1, 4.-75-1, fromjfive modelslThus, the architectural model 4 -75-1 provides the best accuracy withK452 iteration epochs and MSE is 0.00001536

Desa Sengkol merupakan salah satu desa yang berada di Kecamatan Pujut, Kabupaten Lombok Tengah, Nusa Tenggara Barat. Secara geografis letak Desa Sengkol sangat strategis karena Desa Sengkol termasuk salah satu desa penyangga Kawasan Ekonomi Khusus Mandalika, dengan ditetapkannya Mandalika sebagai KEK Mandalika berdasarkan PP Nomor 52 Tahun 2014. Permasalahan ang saat ini dihadapi oleh desa yaitu permasalahan lingkungan, hal ini disebabkan karena kurangnya tingkat kesadaran masyarakat tentang pengelolaan sampah, disamping itu sarana prasana seperti armada pengangkut sampah serta TPA dan TPS masih sangat terbatas. Alternatif solusi yang dapat dilakukan untuk mengatasi permasalahan tersebut adalah dengan mengadakan kegiatan pengelolaan sampah rumah tangga menjadi pupuk kompos organik cair (POC) dan bokashi. Tujuan dari program ini adalah memberdayakan masyarakat Desa Sengkol dalam membuat pupuk organik cair dan bokashi menggunakan sampah organik rumah tangga. Metode yang digunakan yaitu tahap pra pelaksanaan, tahap pelaksanaan dan tahap evaluasi atau pengecekan. Hasil dari program pengabdian masyarakat ini yaitu masyarakat Desa Sengkol khususnya Dusun Senkol 1 dan 4 memiliki pengetahuan tentang pengolahan sampah dimana masyarakat sudah mampu memilah sampah rumah tangga dan mengolahnya menjadi pupuk kompos cair dan bokashi. Untuk mempercepat proses penguraian atau fermentasi pupuk membutuhkan cairan EM4. Hasil monitoring dan evaluasi menunjukkan bahwa pengolahan sampah rumah tangga menjadi pupuk kompos merupakan langkah tepat dalam menanggulangi permasalah sampah rumah tangga yang ada di Desa Sengkol. Sampah bisa mengahasilkan produk yang memiliki nilai guna dan kedepannya masyarakat Desa Sengkol berkomitmen dalam mengembangkan pupuk kompos dari sampah organik sebagai upaya berkelanjutan dari program pengabdian masyarakat.

The development of the internet network and network equipment is currently very rapid, to meet the needs of internet usage, network devices are used as supporting tools in service access and network deployment. According to research conducted in a performance comparison analysis between the default firmware and the openwrt firmware [1], the performance of the network device is not only determined by the hardware specifications contained in the network device, but is also determined by the firmware in the network device. according to a literature review from various sources that the openwrt firmware can be used as a firmware solution to improve the performance of network devices that have limited service features and as firmware updates for network devices that do not get development support from vendors.The research will be conducted by analyzing the comparison of the performance of the Gl iNet Wireless Router network device which was created for the openwrt firmware and already using the openwrt firmware from the manufacturer, with the Tp Link Wireless Router network device, which is a network device that will implement the openwrt firmware. The design is carried out using the PPDIOO Life-Cycle Approach network development method, and a comparative analysis of network quality using QoS (Quality of Service) parameters.The final result of this research is how to implement and how the openwrt firmware runs on network devices that are not actually using the original firmware based on the results of network parameters jitter, delay, packet loss, throughput and signal strength testing in internet service access. Keywords : OpenWrt, Quality of Service, PPDIOO, Life-Cycle Approach.

Human rights are a combination of natural rights that are universal, belong to every human being, and have been affixed to a person from birth as a direct gift or gift from God Almighty. Human rights must be upheld by every person, state, government, and law, especially in the context of the rule of law, which has become a characteristic of the rule of law in order to ensure the protection of human rights that have been enshrined in the constitutions and national laws of all legal states. Because, in a state of law, it highlights the existence of equality and equality before the law, without exception. As a result, the writing of this article is intended to see and deepen the phenomenon of human rights protection in the notion that leads to a rule of law, particularly in Indonesia, which is one of the world's rules of law countries. In order to obtain results and conclusions from the formulation of the problem, this article was created utilizing descriptive methods and data collecting through literature study.

Kemajuan teknologi dalam dunia pendidikan memberikan tuntutan untuk meningkatkan kemampuan kognitif dasar dalam proses pembelajaran, salah satunya adalah kemampuan berpikir analisis. Materi jaringan pada tumbuhan merupakan materi yang memerlukan kemampuan berpikir analisis dari pengamatan dua dimensi kepada obyek yang nyata dalam tiga dimensi sehingga perlu dikembangkan sebuah media pembelajaran yang bersifat konstruktif, ringkas dan jelas untuk melatihkan keterampilan berpikir analisis siswa. Tujuan dari penelitian ini yaitu menghasilkan e-poster berbasis infografis yang layak berdasarkan validitas, kepraktisan dan keefektifan. Penelitian pengembangan ini menggunakan model ADDIE (Analysis, Design, Development, Implementation, Evaluation). Validitas e-poster berbasis infografis diperoleh dari hasil validasi oleh validator. Kepraktisan e-poster diperoleh hasil angket respon siswa dan keefektifan e-poster diukur dari indikator hasil belajar yang diujicobakan pada 30 siswa kelas XI SMA Negeri 1 Tarik. Data dianalisis secara deskriptif kuantitatif. Berdasarkan hasil uji validitas e-poster berbasis infografis mendapat presentase skor sebesar 86% dengan kategori sangat valid, kepraktisan memperoleh skor 88% dengan kategori sangat praktis dan keefektifan diperoleh hasil indikator mengorganisasikan dan indikator membedakan mendapat skor 81% kategori sangat efektif, sedangkan indikator menghubungkan mendapat skor 0% kategori tidak efektif. Berdasarkan hasil tersebut, e-poster berbasis infografis pada materi jaringan pada tumbuhan untuk melatihkan keterampilan berpikir analisis siswa kelas XI SMA dinyatakan sangat valid, sangat praktis dengan dua indikator sangat efektif untuk diterapkan pada pembelajaran. Kata Kunci: berpikir analisis, e-poster, infografis, jaringan pada tumbuhan

Masalah dalam penelitian adalah terjadinya penomena masyarakat beramai-ramai melakukan olahraga sepeda dimana sebelum masa pandemi covid 19 masyarakat jarang berolahraga khususnya olahraga sepeda. Adapun penelitian ini bertujuan untuk melihat sejauh mana motivasi masyarakat melakukan olahraga sepeda pada masa covid-19 di Kecamatan Sungai Pagu Kabupaten Solok Solok Selatan. Penelitian ini tergolong pada penelitian deskriptif, yaitu untuk menjelaskan fakta, keadaan sampel maupun peristiwa dengan benar bersifat alamiah maupun perbuatan manuasia. Sampel dalam penenelitian ini berjumlah 50 orang. Data dikumpulkan menggunakan kusioner atau angket. Hasil angket disusun dan diolah secara deskriptif melalui persentase. Hasil penelitian ini adalah nilai rata-rata motivasi masyarakat dalam berolahraga sepeda pada masa covid-19 di Kecamatan Sungai Pagu Kabupaten Solok Selatan yaitu 3,58 dengan kategori baik. Berdasarkan data yang didapatkan sub indikator paling tinggi adalah sub indikator fisik dengan rata-rata skor 4,04 dengan persentase 81% pada kategori sangat baik dan yang paling rendah adalah sub indikator aktualisasi diri dengan rata-rata 3, 21 pada kategori baik dengan pesentase 64%.

Developing safe and effective therapeutic modalities remains a critical challenge for improving the prognosis of patients with colorectal cancer (CRC). In this regard, targeting epigenetic regulation in cancers has recently emerged as a promising therapeutic approach. Since several natural compounds have recently been shown to be important epigenetic modulators, we hypothesized that Ginseng might exert its anti-cancer activity by regulating DNA methylation alterations in CRC. In this study, a series of cell culture studies were conducted, followed by their interrogation in patient-derived 3D organoid models to evaluate Ginseng’s anti-cancer activity in CRC. Genome-wide methylation alterations were interrogated by undertaking MethylationEpic BeadChip microarrays. First, 50% inhibitory concentrations (IC50) were determined by cell viability assays, and subsequent Ginseng treatment demonstrated a significant anti-cancer effect on clonogenicity and cellular migration in CRC cells. Treatment with Ginseng potentiated cellular apoptosis through regulation of apoptosis-related genes in CRC cells. Furthermore, Ginseng treatment downregulated the expression of DNA methyltransferases (DNMTs) and decreased the global DNA methylation levels in CRC cells. The genome-wide methylation profiling identified Ginseng-induced hypomethylation of transcriptionally silenced tumor suppressor genes. Finally, cell culture-based findings were successfully validated in patient-derived 3D organoids. In conclusion, we demonstrate that Ginseng exerts its anti-tumorigenic potential by regulating cellular apoptosis via the downregulation of DNMTs and reversing the methylation status of transcriptionally silenced genes in CRC.

Studi ini bertujuan untuk merancang strategi pemberdayaan kader kesehatan melalui inovasi ginger hot pack sebagai perawatan rumah untuk menurunkan tekanan darah dan kolesterol. Penelitian ini menggunakan studi quasi eksperimen dengan desain time series. Subyek penelitian adalah kader kesehatan. Teknik pengambilan sampel dengan purposive sampling. Pelatihan kader dilaksanakan pada minggu pertama, kemudian kader mengajarkan pada klien hipertensi mengenai penggunaan ginger hot pack, dan melakukan pengukuran tekanan darah dan kolesterol pada minggu ke-2 dan ke-3. Hasil penelitian menunjukkan bahwa ada penurunan tekanan darah secara signifikan dengan nilai p=0,001. Terjadi penurunan kolesterol dengan p=0,57 tetapi tidak signifikan. Kesimpulan dalam penelitian ini adalah strategi pemberdayaan kader dengan ginger hot pack dapat menurunkan tekanan darah.

Pada tahun 1960-an hingga 1970an praktik dan teori hukum di masyarakat tidak berjalan dengan maksimal atau belum sesuai dengan apa yang seharusnya. Hal ini menjadi salah satu pemicu lahirnya pemikiran hukum yang kritis atau disebut dengan critical legal studies. meski pemikiran hukum kritis ini tergolong baru dan banyak yang beranggapan bahwa ini bukan sebuah pemikiran hukum namun dengan lahirnya gerakan ini memberi banyak manfaat dalam dunia hukum baru dan memperkaya khazanah keilmuan hukum dan menjadi sebab lahirnya pemikiran feminist jurisprudence dan critical race theories.

Cumulative evidence has shown that mechanical and frictional forces exert distinct effects in the multi-cellular aortic layers and play a significant role in the development of abdominal aortic aneurysms (AAA). These mechanical cues collectively trigger signaling cascades relying on mechanosensory cellular hubs that regulate vascular remodeling programs leading to the exaggerated degradation of the extracellular matrix (ECM), culminating in lethal aortic rupture. In this review, we provide an update and summarize the current understanding of the mechanotransduction networks in different cell types during AAA development. We focus on different mechanosensors and stressors that accumulate in the AAA sac and the mechanotransduction cascades that contribute to inflammation, oxidative stress, remodeling, and ECM degradation. We provide perspectives on manipulating this mechano-machinery as a new direction for future research in AAA.

The spread of HIV is on the rise and has become a global issue, especially for underdeveloped and developing countries. This is due to the fact that HIV majorly occurs asymptomatically and is implausible for early diagnosis. Recent advances in research and science have enabled the investigation of a new potential treatment involving gene-based therapy, known as RNA interference (RNAi) that will direct gene silencing and further compensate for natural variants and viral mutants. Several types of small regulatory RNA are discussed in this present study, including microRNA (miRNA), small interfering RNA (siRNA), and short hairpin RNA (shRNA).This paper examines the mechanism of RNAi as a viable HIV therapy, using a minimum of four shRNAs to target both dispensable host components (CCR5) and viral genes (Gag, Env, Tat, Pol I, Pol II and Vif). Moreover, a multiplexed mechanism of shRNAs and miRNA is known to be effective in preventing viral escape due to mutation as the miRNA develops a general polycistronic platform for the expression of a large amount of shRNA-miRs. Several administration methods as well as the advantages of this RNAi treatment are also discussed in this study. The administration methods include (1) ex vivo delivery with the help of viral vectors, nanoparticles, and electroporation, (2) nonspecific in vivo delivery using non-viral carriers including liposomes, dendrimers and aptamers, as well as (3) targeted delivery that uses antibodies, modified nanoparticles, nucleic acid aptamers, and tissue-specific serotypes of AAV. Moreover, the advantages of this treatment are related to the effectiveness in silencing the HIV gene, which is more compatible compared to other gene therapy treatments, such as ZFN, TALEN, and CRISPR/Cas9.

The development of the times is always followed by technological developments, digital technology has brought a major influence on human life. One example is information and communication technology. Various types of cell phones with the sophistication they have have changed the way humans exchange information and communicate. Various features are available in cellular phones, one of which is the short message service feature or commonly known as SMS. Initially this feature was used to make it easier for humans to send and receive short messages. Over time the feature or short message service is used by criminals for personal gain. Crime in the digital world is called cybercrime. Therefore, the purposes of this study are to examine the legal arrangements for victims of sweepstakes fraud through short message services and reveal forms of legal protection for victims of fraud through short message services. This research is designed with normative legal research using a legal and conceptual approach. Sources of data used are primary and secondary legal data collected using the literature study method. After the research data is collected, the final stage is processing and analyzing the data in a qualitative descriptive manner. The results of the study reveal that the crimes committed by the perpetrators are criminal acts of fraud which have been regulated in article 378 of the Criminal Code and have also been accommodated in the ITE Law which is regulated in article 28 paragraph (1). Furthermore, the victim has legal protection as regulated in the ITE Law.

Introduction: Genetic hereditary predisposes to AAA. However, the pathobiological relevance of single nucleotide polymorphisms (SNPs) to the development of AAA is not fully elucidated. The present study investigated 86 AAA SNPs from GWAS and clinical cohort studies to determine their phenotypical vulnerabilities in AAA. Methods SNPs from GWAS catalog and available clinical cohort were collected in this study. The SNPs were annotated using snpXplorer AnnotateMe tool to identify its chromosomal position, minor allele frequency (MAF), CADD (Combined Annotation Dependent Depletion)-annotation based pathogenicity score, variant consequence, & their affected gene. Gene enrichment analysis was performed on AAA-related genes using Gene Ontology (GO) terms and clustered using REVIGO. The plug-in GeneMANIA in Cytoscape was applied to reveal an association network integration of the SNPs with associated genes and functions. Results 15 SNPs affecting 20 genes with a CADD pathogenicity score above 10 were identified. AAA SNPs were predominantly located on chromosome 3 and 9. Stop-gained rs5516 KLK1 obtained high frequency in AAA (17.8%) and was associated with proinflammatory and vascular remodeling phenotypes. Our clinical cohort identified significant positive association of the SNPs presence with aortic diameter (P = 2.003e− 05), hypertension (P = 0.013), dyslipidemia (P = 0.042), and smoking history (P = 0.037) in AAA groups. Gene-ontology and Network association analysis showed that AAA SNPs and their associated genes could regulate signaling pathways including lipid metabolism, extracellular matrix organization, smooth muscle cell proliferation, and oxidative stress, suggesting that these AAA traits could be inheritable. Conclusion We show a library of inborn SNPs and associated genes that manifest in the presence of risk factors and uncovered their pathological signaling traits that are likely transmitted through familial lineage culminating in AAA development.

Abdominal aortic aneurysms (AAA) is a multifactorial complex disease with life-threatening consequences. While Genome-wide association studies (GWAS) have revealed several single nucleotide polymorphisms (SNPs) located in the genome of individuals with AAA, the link between SNPs with the associated pathological signals, the influence of risk factors on their distribution and their combined analysis is not fully understood. We integrated 86 AAA SNPs from GWAS and clinical cohorts from the literature to determine their phenotypical vulnerabilities and association with AAA risk factors. The SNPs were annotated using snpXplorer AnnotateMe tool to identify their chromosomal position, minor allele frequency, CADD (Combined Annotation Dependent Depletion), annotation-based pathogenicity score, variant consequence, and their associated gene. Gene enrichment analysis was performed using Gene Ontology and clustered using REVIGO. The plug-in GeneMANIA in Cytoscape was applied to identify network integration with associated genes and functions. 15 SNPs affecting 20 genes with a CADD score above ten were identified. AAA SNPs were predominantly located on chromosome 3 and 9. Stop-gained rs5516 SNP obtained high frequency in AAA and associated with proinflammatory and vascular remodeling phenotypes. SNPs presence positively correlated with hypertension, dyslipidemia and smoking history. GO showed that AAA SNPs and their associated genes could regulate lipid metabolism, extracellular matrix organization, smooth muscle cell proliferation, and oxidative stress, suggesting that part of these AAA traits could stem from genetic abnormalities. We show a library of inborn SNPs and associated genes that manifest in AAA. We uncover their pathological signaling trajectories that likely fuel AAA development.

Background: MT1-MMP (membrane-type 1 matrix metalloproteinase, MMP-14) is a transmembrane-anchored protein with an extracellular proteinase domain and a cytoplasmic tail devoid of proteolytic functions but capable of mediating intracellular signaling that regulates tissue homeostasis. MT1-MMP extracellular proteolytic activity has been shown to regulate pathological remodeling in aortic aneurysm and atherosclerosis. However, the role of the nonproteolytic intracellular domain of MT1-MMP in vascular remodeling in abdominal aortic aneurysms (AAA) is unknown. Methods: We generated a mutant mouse that harbors a point mutation (Y573D) in the MT1-MMP cytoplasmic domain that abrogates the MT1-MMP signaling function without affecting its proteolytic activity. These mice and their control wild-type littermates were subjected to experimental AAA modeled by angiotensin II infusion combined with PCSK9 (proprotein convertase subtilisin/kexin type 9) overexpression and high-cholesterol feeding. Results: The mutant mice developed more severe AAA than the control mice, with concomitant generation of intraaneurysmal atherosclerotic lesions and dramatically increased macrophage infiltration and elastin degradation. Aortic lesion-associated and bone marrow–derived macrophages from the mutant mice exhibited an enhanced inflammatory state and expressed elevated levels of proinflammatory Netrin-1, a protein previously demonstrated to promote both atherosclerosis and AAA. Conclusions: Our findings show that the cytoplasmic domain of MT1-MMP safeguards from AAA and atherosclerotic plaque development through a proteolysis-independent signaling mechanism associated with Netrin-1 expression. This unexpected function of MT1-MMP unveils a novel mechanism of synchronous onset of AAA and atherogenesis and highlights its importance in the control of vascular wall homeostasis.

Baitul Maal wa Tamwil (BMT) is an institution that supports the economic activities of low-income communities based on the Islamic sharia economic system. KSPPS BMT KUBE SEJAHTERA 068 Sampit was formed on January 12, 2006 with the legal entity Cooperative No. 07/Kep-BH/DK.PM/VIII/2006, and is a Sharia Savings and Loans Cooperative (KSPPS) which has approximately ten years of experience serving and partnering with the community. At KSPPS BMT-Sampit there is still no auditing system to monitor whether the existing technology is running well and efficiently, as well as to provide an assessment of the maturity level of information system technology, therefore the author uses the Cobit 5 framework for the audit system by focusing on 2 domains that the choices are DSS01 (manage operation) and DSS05 (manage security service) based on the results of calculations that have been done, the maturity level of information technology in KSPPS BMT-Sampit is at level 4 (Predictable processes) for DSS01, and based on level 4 (Predictable Processes) for DSS05

The development of computer science as a human tool, especially in data processing media and the excellence factor of the computer itself which can be in the form of technological advances in information. With that we will produce goals information that is fast and precise so that it helps in making decisions in processing data items, both goods in and out of the process of buying and selling goods. Store shoes Abang Adik is a business that is engaged in the sale of shoes and this shop has many obstacles in the report and the use of computers that are not maximal. In this case the back order method can be used to solve the problem so as to avoid store losses. With this method the back order method functions as if the goods in the warehouse are running low then the seller will know and will directly order the goods to the supplier to add to the stock of empty goods. With the system of controlling goods using the back order method can prevent the shortage of goods in the store shoes Abang Adik and the calculation of inventory costs more accurately. Keyword: Stock Controlling; Visual Basic; Back Order Method. Abstrak: Perkembangan terhadap ilmu komputer sebagai alat bantu manusia khususnya dalam media pengolahan data dan faktor keunggulan dari komputer itu sendiri yang dapat berupa kemajuan teknologi dibidang informasi. Dengan hal itu kita akan menghasilkan tujuan informasi yang cepat dan tepat sehingga membantu dalam membuat keputusan dalam mengolah data barang, baik barang yang masuk dan keluar pada proses pembelian maupun penjualan barang-barang. Toko Abang Adik Shoes merupakan usaha yang bergerak di bidang penjualan sepatu dan toko ini ada banyak kendala dalam laporan serta penggunaan komputer yang kurang maksismal. Dalam hal ini metode back order dapat digunakan untuk memecahkan masalah tersebut sehingga tehindar dari kerugian toko. Dengan hal ini metode back order berfungsi sebagai apabila barang yang berada digudang menipis maka penjual akan tahu dan secara langsung akan memesan barang kepada supplier untuk menambah stok barang yang kosong. Dengan adanya sistem pengontrolan barang dengan metode back order dapat mencegah terjadinya kekurangan stock barang pada Toko Abang Adik Shoes dan perhitungan biaya-biaya persediaan lebih akurat. Kata Kunci: Stock Controlling; Visual Basic; Metode Back Order.

Berdasarkan keterangan, kecamatan Langkapura merupakan satu dari empat belas Kecamatan yang termasuk dalam kategori zona merah di Bandar Lampung. Pada 14 maret 2020, ditemukan pasien positif COVID-19 pertama di Lampung yaitu warga salah satu kelurahan di wilayah administratif Kecamatan Langkapura. Oleh karena itu peran kader sangat di perlukan dalam pelayanan. Salah satu upaya yang dapat dilakukan dengan memberikan pengetahuan. Tujuan dari kegiatan ini adalah untuk meniningkatkan pengetahuan mengenai covid. Pelaksanaan kegiatan dibantu oleh FK malahayati pada bulan Desember 2020. Hasil dari kegiatan ini adalah meningkatnya pengetahuan kader sehingga dapat disimpulkan bahwa penyuluhan pada kader sangat efektif. Kata Kunci: Penyuluhan, kader, covid. ABSTRACT Based on information, Langkapura sub-district is one of fourteen sub-districts included in the red zone category in Bandar Lampung. On March 14, 2020, the first positive COVID- 19 patient was found in Lampung, a resident of a sub-district in the administrative area of Langkapura District. Therefore, the role of cadres is needed in service. One of the efforts that can be done by providing knowledge. The purpose of this activity is to increase knowledge about Covid. The implementation of activities assisted by FK malahayati in December 2020. The result of this activity is the knowledge of cadres so it can be ignored that counseling to cadres is very effective. Keywords : Counseling, cadres, covid

Watershed Area is a land area that receives rain water to then flow it back through one main river to downstream. Watershed section upstream is often the focus of watershed management planning because in addition to its, as acatchment, there are alsonbiophsical links to downstream areas. This study aims to determine the level of erosion and sedimentation in Air Betung sub-watershed. Erosion and sedimentation analysis used the formula USLE (Universal Soil Loss Equation) which was influenced by faktors such as, rain erosion index (R), soil erodibility index (K), slope length and slop (LS), management factor values safe and assement of land coversation factors (CP). Based on the result of the analysis with using the USLE method and approached with ILWIS 3.3 showed that value erosion was 54,565.73 tons/ha/year. From the results of measurements in the large sediment field hovering that occured in Betung sub-watershed was 1.26 grams in 2L water with debit 5.25m3/sec

To speak English fluently is a challenging ability for language learners in learning English. But, speech errors tend to cause students speaking difficulties. The point of this study was to describe the kinds of errors made by tenth-grade students at SMAN 1 Tanjung Lubuk when reciting descriptive text. This was a qualitative investigation. The study focused on SMA Negeri 1 Tanjung Lubuk's tenth-grade students in Academic 2019/2020. Recording or videotaping students' speaking performances, as well as English instructor scores, served as the research instrument in this study. The following steps were taken to analyze the data: a) data collection, b) error identification, c) categorization into error categories, d) statement of the relative frequency of error types, and e) identification of the target language's areas of difficulty, and f) therapy. The study's findings revealed that grammatical and speech errors were the most common types of speaking errors.

Aortic stiffening is an inevitable manifestation of chronological aging, yet the mechano-molecular programs that orchestrate region- and layer-specific adaptations along the length and through the wall of the aorta are incompletely defined. Here, we show that the decline in passive cyclic distensibility is more pronounced in the ascending thoracic (ATA) compared to distal segments of the aorta and that tissues in both the medial and adventitial compartments of the ATA stiffen during aging. Single-cell RNA sequencing of aged ATA tissues reveals altered cellular senescence, remodeling, and inflammatory responses accompanied by enrichment of T-lymphocytes and rarefaction of vascular smooth muscle cells, compared to young samples. T-lymphocytes accumulate in the adventitia and likely promote fibrosis, while activation of mechanosensitive piezo-1 enhances medial vasoconstriction. These results portray the immuno-mechanical aging of the ATA as a process that culminates in a stiffer conduit permissive to the accrual of multi-gerogenic signals priming to disease development.

The Covid-19 pandemic has caused learning to be carried out online. Not all students, however, are ready for online learning. This study aims to examine the level of readiness of eighth-grade students at a junior high school through an explanatory sequential mixed method design consisting of quantitative and qualitative phases. Student readiness for online learning in this study was reviewed from five dimensions: self-directed learning, motivation for learning, computer/internet self-efficacy, learner control, and online communication self-efficacy. The Online Learning Readiness Scale (OLRS) survey proposed by Hung (2010) with a five-point-Likert scale was used to collect quantitative data. The data were analyzed quantitatively, and the level of readiness was measured utilizing the e-learning readiness assessment model suggested by Aydin and Tasci (2005). Follow-up interviews were then held to support the quantitative data. The results showed that the majority of students entered the level of "ready but needs a few improvements". However, there was one item in the dimension of self-directed learning that was included in the level of "not ready needs some work". The implication of this study is the need to encourage students to actively communicate in online learning, especially for shy students.ABSTRAKPandemi Covid-19 menyebabkan pembelajaran dilakukan secara online. Namun, tidak semua siswa siap dengan pembelajaran online. Penelitian ini bertujuan untuk menguji tingkat kesiapan siswa kelas VIII sebuah sekolah menengah pertama melalui penelitian explanatory sequential mixed method yang terdiri dari tahap kuantitatif dan kualitatif. Kesiapan siswa untuk pembelajaran online ditinjau dari lima dimensi: pembelajaran mandiri, motivasi belajar, efikasi diri komputer / internet, kontrol peserta didik, dan efikasi diri komunikasi online. Survei Online Learning Readiness Scale (OLRS) yang digagas oleh Hung (2010) dilengkapi dengan skala Likert lima poin digunakan untuk mengumpulkan data kuantitatif. Data kemudian dianalisis dengan menggunakan analisis deskriptif kuantitatif dan tingkatannya diukur dengan model penilaian kesiapan E-learning yang dikemukakan oleh Aydin dan Tasci (2005). Wawancara kemudian dilakukan untuk mengumpulkan data guna mendukung data kuantitatif. Hasil penelitian menunjukkan bahwa secara keseluruhan siswa memasuki level “siap, tetapi perlu sedikit perbaikan”. Namun, ada satu item dalam dimensi pembelajaran mandiri yang termasuk dalam tingkat "belum siap, perlu peningkatan". Implikasi dari penelitian ini adalah perlunya mendorong siswa untuk aktif berkomunikasi dalam pembelajaran online, khususnya bagi siswa yang pemalu.

The increasing number of malware spread in the world today, then there will be more opportunities to commit crime, so readiness is needed for every internet user in dealing with these crimes. The readiness to handle crime is called digital forensic readiness. Therefore, we need a specific digital forensic readiness model to measure the level of readiness of internet users or institutions in achieving malware attacks. This model has the main components used to determine or calculate the level of readiness of internet users or institutions, the main components are the strategy component, the policy & procedure component, the technology & security component, the digital forensic response component, the control & legality component. The calculation method used in this study is a Likert Scale, with this method the results will be obtained that are closer to the real situation. The value / index of readiness level obtained will provide recommendations to internet users and these recommendations can be used to make improvements properly and on target.

Latar Belakang : Hipertensi masih menjadi masalah kesehatan masyarakat utama dan penyebab utama kematian di dunia. Tekanan darah tinggi dapat dicegah dengan mempraktikkan kebiasaan hidup sehat dan mengobati kondisi medis. Selain obat terapi komplementer diperlukan untuk mengontrol hipertensi. Salah satu terapi komplementer yaitu senam otak (Brain Gym). Tujuan: Mengetahui pengaruh Brain Gym terhadap tekanan darah pada penderita hipertensi. Metode: quasi eksperimen dengan desain One Group Pretest – Postest Design tanpa adanya kelompok kontrol digunakan oleh peneliti. Analisis T-Test digunakan untuk mengetahui perbedaan rata-rata antara tekanan darah sebelum dan sesudah perlakuan Brain Gym. Hasil: ada perbedaan rata-rata antara pre dan post pada tekanan sistolik sebesar 3,913 mmHg, t hitung (2,510) > t table (2,04) dan p.value (0,02) < ? (0,05). Sedangkan untuk tekanan diastolik sebesar 2,783 mmHg, t hitung (2,227) > t table (2,04) dan p.value (0,036) < ? (0,05). Kesimpulan: terdapat pengaruh Terapi Brain Gym terhadap tekanan darah pada pasien hipertensi. Saran: Pasien Hipertensi di RW 13 Desa Giwangan disarankan untuk melakukan Brain Gym sebagai terapi alternatif untuk mengurangi tekanan darah. Kata kunci: brain gym, hipertensi, manajemen hipertensi

The number of vehicles at Jenderal Achmad Yani University continues to increase, thus requiring increased parking security on campus. For this reason, Jenderal Achmad Yani University implemented a paid parking gate system, but this turned out to have an impact on the emergence of a long vehicle queue at the parking exit gate. This study aims to find a solution to minimize the length of the queue at the parking gate. In this study two alternatives are proposed, namely adding ticket booths (Alternative 1) or improving service time by using an automatic card system (Alternative 2). The results obtained show that for the next 5 years, Alternative 1 needs to add 1 ticket booth and Alternative 2 does not need to add ticket booth. For the next 10 years, Alternative 1 needs to add 1 more ticket booth in 2027, while Alternative 2 requires the addition of 1 ticket booth in 2026. Keywords : parking, queue, service time, automatic card system Abstrak Jumlah kendaraan di Universitas Jenderal Achmad Yani meningkat terus, sehingga memerlukan peningkatan keamanan parkir di kampus. Dengan alasan itu, Universitas Jenderal Achmad Yani menerapkan sistem gerbang parkir berbayar, tetapi hal ini ternyata berdampak pada timbulnya antrian kendaraan yang panjang di gerbang keluar parkir. Tujuan penelitian adalah mencari solusi untuk meminimalkan panjang antrian di gerbang keluar parkir. Pada studi ini diusulkan 2 alternatif, yaitu menambah gardu (Alternatif 1) atau memperbaiki waktu pelayanan dengan menggunakan sistem kartu otomatis (Alternatif 2). Hasil yang didapat menunjukkan bahwa untuk 5 tahun mendatang Alternatif 1 perlu menambah 1 gardu dan Alternatif 2 tidak perlu menambah gardu. Untuk 10 tahun mendatang, Alternatif 1 perlu menambah 1 gardu lagi pada tahun 2027, sedangkan Alternatif 2 membutuhkan penambahan 1 gardu pada tahun 2026. Kata -kata k unci : parkir, antrian, waktu pelayanan, sistem kartu otomatis

Hepatocellular carcinoma (HCC) is the sixth-most common type of cancer worldwide and chronic Hepatitis C virus (HCV) represents the main etiological factor in developed countries. HCV promotes hepatocarcinogenesis through persistent liver inflammation and dysregulation of cell signaling pathways. The introduction of direct-acting antivirals (DAAs) resulted in a significant improvement in the eradication of the virus, with an expected reduction of HCC incidence. However, the risk of HCC development can persist after DAA treatment. Recent studies have investigated the potential use of molecular biomarkers that predict HCC occurrence or recurrence helping the stratification of patients under surveillance. This review aimed to summarize all pre-clinical exploration of predictive biomarkers to identify DAA-treated patients at risk for HCC development. Dysregulated microRNAs, lncRNAs, histone modifications, cytokines, proteins, and sphingolipids represent various classes of HCC risk predictors identified in two different biological sources (tissue and serum). The non-invasive serum markers can provide a more accessible means to perform clinical monitoring and predict the risk of HCC. In addition, conditions like cirrhosis, predisposing to HCC, strongly correlate with most of the molecular predictors identified, supporting the value of these molecules as possible biomarkers of HCC in DAA-treated patients.

Introduction: Loss of vascular smooth-muscle cells (vSMC) and subsequent defective replenishment of functional vSMC de novo are pathological hallmarks of abdominal aortic aneurysm (AAA). Evidence suggests that clusters of progenitors can be reprogrammed into vSMC lineage following vascular injury. However, the landscape of vSMC precursors and reprograming signatures that determine their fate in AAA is undefined. Hypothesis: We hypothesize that quiescent progenitor pools reside in aorta and undergo spatiotemporal fate decision into mature vSMC in AAA. We speculate that distinct ligand-receptor and transcriptional signals gear their pathogenic trajectories into dysfunctional vSMC in AAA. Methods & Results: Single-cell RNA-sequencing (scRNA-seq) identified vascular progenitor cells (Cd34 + Pdgfra + ) in murine (angiotensin II-induced) and human AAA. Pseudotime analysis tracked two differentiation fates of progenitors into divergent mature vSMC pools characterized by enrichment in contractile cytoskeleton machinery (Acta2 + Myh11 + ) or abnormally supplemented with matrix remodeling genes (Mmp2 + Col8a1 + ). Mmp2 + Col8a1 + clusters were dominant in AAA suggesting pathological reprograming in AAA. Gene regulatory network analysis mapped distinct libraries of upstream transcription factors in each mature vSMC states in AAA. Acta2 + Myh11 + and Mmp2 + Col8a1 + transcriptomes were driven by opposing actions of Pparg and its repressor Runx1 respectively. Interestingly, cellular interaction analysis revealed that platelet-derived Pdgfb fueled the phenotypic switch into Mmp2 + Col8a1 + vSMC via its receptor Pdgfra. Dampening Pdgfra signaling by systemic platelet depletion repressed Runx1 activation thereby increasing Pparg transcriptomic activity in progenitors in the aortic wall. This rescued functional regeneration of vSMC (Acta2 + Myh11 + ) with contractile properties consistent with reduced aortic damage and diminished AAA incidence. Conclusion: Our data demonstrate that platelets are novel actors capable of awakening progenitor pools by coding their fate into pathogenic vSMC lineage in AAA. We provide evidence suggesting that strategies aimed at sustaining vSMC contractile destiny could encourage repair of vascular damage in AAA.

During this Covid-19 pandemic, almost all parts of the world are affected, including education process in school. At this time, students are learning from home, which causes many new challenges both in terms of physical and psychological. This psychological challenge can cause great pressure on students, including students from superior schools such as SMPN 1 Ngunut. One of the factors that can help students manage their psychological pressure better is their personality such as hardiness. Therefore, this study aims to determine whether there is a difference in hardiness among 8th grade students of SMPN 1 Ngunut. The population of this study was 357 with a sample of 192 students (superior class: 63 students and regular class: 129 students) obtained by simple random sampling technique. This study uses the Hardiness Scale (α = 0.919) with 28 items and 4 alternative choices to measure the hardiness level in the students. Based on the results of the independent sample t-test (the sig. (2-tailed) 0.019 < 0.05 and the sig. of variances 0.417 > 0.05), this study found that there are differences in hardiness in 8th grade students of SMPN 1 Ngunut between superior and regular classes. The superior class students have a tendency to have higher hardiness level than the regular class students. Even though overall students in both superior and regular class show hardiness in moderate level, the students from the superior class have the tendency to have hardiness in moderate to high level than the students in regular class that show the tendency to have moderate to low level of hardiness. Keywords: hardiness, junior high school, superior class, regular class

Background Around 70% of breast cancers (BCs) are estrogen receptor-α (ERα)-positive. Adjuvant endocrine therapy is used to reduce estrogen levels and inhibit signal transduction through the ER. The anti-estrogen drugs that are most commonly used in endocrine therapy belong to the selective ER modulator (SERM) class and include tamoxifen. Although it has been used for three decades in cases of early-stage and ERα-positive BC, resistance to tamoxifen is a common problem. microRNAs (miRNAs) have a potential role in demonstrating BC resistance to tamoxifen therapy. Hence, there is a need to investigate the expression of miRNA-221 (miR-221) in luminal-subtype BC patients receiving tamoxifen therapy. Methods This case-control study investigated luminal-subtype BC patients who had undergone endocrine therapy for at least 1 year. The case group comprised patients with local or metastatic recurrence, and the control group comprised patients without local or metastatic recurrence. Results There was a significant difference in miR-221 expression (p = 0.005) between the case and control groups. There were no significant differences between the groups that were positive and negative for the progesterone receptor (PR) (p = 0.25), had high and low marker of proliferation Ki-67 levels (p = 0.60), were positive and negative for lymphovascular invasion (p = 0.14), and had stage 2 and stage 3 cancer (p = 0.25). Conclusion miR-221 expression was higher in tamoxifen-resistant BC cases. miR-221 is a potential biomarker of tamoxifen resistance., Highlights • Tamoxifen is used to treat early-stage and estrogen receptor-α-positive breast cancer. • Resistance to tamoxifen is a common problem. • Serum microRNA-221 levels were higher in patients with local recurrence and metastasis. • microRNA-221 is a potential serum biomarker of tamoxifen resistance.

This research aims to find out two matters. the first matter is to find out how the paradigm of Law Number 5 Year 1986 and Law Number 30 Year 2014 on decisions that are petitioned to State Administrative Officials (hereinafter TUN Officials). Second, to find out the legal implications of the differences in the position of decisions that are applied to TUN Officials based on Law Number 5 Year 1986 and Law Number 30 Year 2014. The following research results, (1) that related to the paradigm of Article 3 of the Law on State Administrative Court and Article 53 of the Government Administration Law, should be related to the type of decision.. (2) The legal implication of the decision’s differences that have been petitioned to TUN officials may allow confusion to occur when it is applied in the process of administering the government and also the process in court.

Technology is currently developing quite widely, information technology is not only technology that functions to work and store data, but also information technology to send or disseminate data. in the selection of scholarships at SDN 4 Mentawa Baru Hulu Sampit in determining the PIP scholarships still using the manual method so that it can cause inefficiencies in the management of scholarship data, as well as errors in determining scholarship recipients. Data management is also done manually, this also causes the process of identifying scholarship decisions to be slow. From these problems, we need a scholarship decision support system that can use data management and also determine scholarship decisions. The author builds a scholarship acceptance decision support system by comparing the WP and SAW methods. it is hoped that this method can determine the right method to be applied in determining scholarships, and can assist school principals and school operators in processing scholarship assessments. Based on the final calculation results, the SAW method and the WP method can produce different scholarship ratings. Based on the WP = Nanang Sujana method as the best alternative and followed by other best alternatives A3, A4, A1, and A2, then the SAW method was obtained by Radhiyatul Maulida as the best alternative and followed by other alternatives A2, A3, A4, and A5. From the comparison results with the MSE (Mean Squared Error) method, the Weighted Product (WP) method produces a higher deviation value than the Simple Addative Weighting (SAW), with a comparison of the deviation value, namely the WP method = 4363,47509 while the SAW method is obtained = 4259 , 71350. Therefore, the Weighted Product (WP) method can be recommended in making scholarship selection decisions at SDN 4 Mentawa Baru Hulu Sampit.

Simple Summary According to the last estimate by the World Health Organization (WHO), more than 71 million individuals have chronic hepatitis C worldwide. The persistence of HCV infection leads to chronic hepatitis, which can evolve into liver cirrhosis and ultimately into hepatocellular carcinoma (HCC). Although the pathogenic mechanisms are not fully understood, it is well established that an interplay between host cell factors, including microRNAs (miRNA), and viral components exist in all the phases of the viral infection and replication. Those interactions establish a complex equilibrium between host cells and HCV and participate in multiple mechanisms characterizing hepatitis C pathogenesis. The present review aims to describe the role of HCV structural and non-structural proteins in the modulation of cellular miRNA during HCV infection and pathogenesis. Abstract Hepatitis C virus (HCV) genome encodes for one long polyprotein that is processed by cellular and viral proteases to generate 10 polypeptides. The viral structural proteins include the core protein, and the envelope glycoproteins E1 and E2, present at the surface of HCV particles. Non-structural (NS) proteins consist of NS1, NS2, NS3, NS4A, NS4B, NS5a, and NS5b and have a variable function in HCV RNA replication and particle assembly. Recent findings evidenced the capacity of HCV virus to modulate host cell factors to create a favorable environment for replication. Indeed, increasing evidence has indicated that the presence of HCV is significantly associated with aberrant miRNA expression in host cells, and HCV structural and non-structural proteins may be responsible for these alterations. In this review, we summarize the recent findings on the role of HCV structural and non-structural proteins in the modulation of host cell miRNAs, with a focus on the molecular mechanisms responsible for the cell re-programming involved in viral replication, immune system escape, as well as the oncogenic process. In this regard, structural and non-structural proteins have been shown to modulate the expression of several onco-miRNAs or tumor suppressor miRNAs.

Cervical cancer is the fourth leading cause of cancer-related death among women worldwide. The chemotherapeutical agent cisplatin, a small platinum-based compound, is considered as the standard therapy for locally advanced cervical cancer or recurrent cancers, sometimes in combination with radiotherapy or other drugs. However, drug resistance and radio-resistance phenomena could reduce the life expectancy of cervical cancer patients. Resistance mechanisms are complex and often involve multiple cellular pathways in which microRNAs (miRNAs) play a fundamental role. miRNAs are a class of endogenous non-coding small RNAs responsible for post-transcriptional gene regulation. Convincing evidence demonstrates that several deregulated miRNAs are important regulators in the onset of drug and radioresistance in cervical cancer, thus underlying their potential applications in a clinical setting. In this review, we summarized the mechanisms by which miRNAs affect both cisplatin and radioresistance in cervical cancer. We also described the regulatory loops between miRNAs and lncRNAs promoting drug resistance. Besides, we reported evidence for the role of miRNAs in sensitizing cancer cells to cisplatin-based chemotherapy, and provided some suggestions for the development of new combined therapies for cervical cancer.

BAB I PENDAHULUANIndonesia merupakan Negara hukum yang taat pada hukum dan peraturanperundang-undangan yang berlaku. Berdasarkan ketentuan Pasal 1 ayat (3)Undang-undang Dasar Negara Republik Indonesia Tahun 1945, “Negara Indonesiaadalah negara hukum”, yang menganut desentralisasi dalam penyelenggaraanpemerintahan, sebagaimana diisyaratkan dalam Pasal 18 ayat (1) Undang-undangDasar Negara Republik Indonesia Tahun 1945 “Negara Kesatuan Republik Indonesiadibagi atas daerah-daerah provinsi dan daerah provinsi itu dibagi atas kabupaten dankota, yang tiap-tiap provinsi, kabupaten, dan kota mempunyai pemerintah daerah,yang diatur dengan undang-undang”. Sebagai Negara hukum, setiap penyelenggaraanurusan pemerintahan haruslah berdasarkan pada hukum yang berlaku (wetmatigheidvan bestuur).1Negara hukum menghendaki segala tindakan atau