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684 results on '"Yogev, Y"'

10. Estimating predictors of severity of Group A Streptococcus infection in pregnancy

Author

Cohen Y, Yogev Y, Abu-Hanna J, Reicher L, Fouks Y, Many A, Dominsky O, and Attali E

Subjects
Pregnancy, medicine.medical_specialty, Text mining, business.industry, Internal medicine, Medicine, Streptococcus infection, business, medicine.disease, Group A
Abstract

Objective: To identify the clinical characteristics of pregnancy associated group A streptococcus (GAS) infection and predictors for intensive care unit (ICU) admission. Design: A retrospective cohort study of culture-proven pregnancy-related GAS infections. Setting and population: a tertiary university-affiliated hospital between 1/2008-7/2020. Methods: Review patient’s electronic records of patients. Main outcome measures: Incidence of pregnancy associated GAS, proportion given prophylaxis and admission to ICU. Results: Of the 143,750 who delivered during the study period, 66 (0.04%) were diagnosed as having a pregnancy associated GAS infection. Fifty-seven of them (86.3%) presented postpartum, and nine (13.6%) had septic abortions. The most common presenting signs and symptoms among puerperal GAS, were postpartum pyrexia (72%), abdominal pain and/or tenderness (33%), and tachycardia (>100 bpm, 22%). Thirteen women (19.6%) developed streptococcal toxic shock syndrome (STSS): 10 of them delivered vaginally, two had caesarean deliveries. Predictors for STSS and ICU admission were: antibiotic administration >24 hours from presentation postpartum, tachycardia, and a C-reactive protein level >200 mg/L. Women that received antibiotic prophylaxis during labour had a significantly lower rate of STSS (0 vs 10, 22.7%; P = 0.04), as evidenced by the delayed interval from delivery to the first presentation of infection among those who received prophylaxis during labour (8 ± 4.8 vs 4.8 ± 4.2 hours, P = 0.008). Conclusion: Deferral of medical intervention >24 hours from the first registered abnormal sign had the most important impact on deterioration of women with invasive puerperal GAS. Antibiotic prophylaxis during labour in women with GAS may reduce complications

Published
2021
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28. Detection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in vaginal swabs of women with acute SARS‐CoV‐2 infection: a prospective study.

Author

Schwartz, A, Yogev, Y, Zilberman, A, Alpern, S, Many, A, Yousovich, R, and Gamzu, R

Subjects
*COVID-19, *SARS-CoV-2, *THIRD trimester of pregnancy, *NEONATAL infections, *LONGITUDINAL method
Abstract

Objective: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is present in the vaginal secretions of both reproductive‐aged and postmenopausal women during acute SARS‐CoV‐2 infection. Design: Prospective study. Setting: A single tertiary, university‐affiliated medical centre in Israel. Time period, 1 June 2020 through to 31 July 2020. Population: Women who were hospitalised in a single tertiary medical centre, who were diagnosed with acute SARS‐CoV‐2 infection by a nasopharyngeal RT‐PCR test. Methods: Women were diagnosed with acute SARS‐CoV‐2 infection by a nasopharyngeal RT‐PCR test. Vaginal RT‐PCR swabs were obtained from all study participants after a proper cleansing of the perineum. Main outcome measures: Detection of SARS‐CoV‐2 in vaginal RT‐PCR swabs. Results: Vaginal and nasopharyngeal swabs were obtained from 35 women, aged 21–93 years. Twenty‐one women (60%) were in their reproductive years, of whom, five were in their third trimester of pregnancy. Most of the participants (57%) were healthy without any underlying medical conditions. Of the 35 patients sampled, 2 (5.7%) had a positive vaginal RT‐PCR for SARS‐CoV‐2, one was premenopausal and the other was a postmenopausal woman. Both women had mild disease. Conclusion: Our findings contradict most previous reports, which did not detect the presence of viral colonisation in the vagina. Although passage through the birth canal exposes neonates to the vaginal polymicrobial flora, an acquisition of pathogens does not necessarily mandate neonatal infection or clinical disease. Nevertheless, when delivering the infant of a woman with acute SARS‐CoV‐2 infection, a clinician should consider the possibility of vaginal colonisation, even if it is uncommon. When delivering the infant of a woman with acute SARS‐CoV‐2 infection, a clinician should consider the possibility of vaginal colonisation. When delivering the infant of a woman with acute SARS‐CoV‐2 infection, a clinician should consider the possibility of vaginal colonisation. [ABSTRACT FROM AUTHOR]

Published
2021
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30. Controversies in Preeclampsia

Author

Sheiner, E. and Yogev, Y., De Carolis, Sara, Di Pasquo, Elvira, Ferrazzani, Sergio, Garofalo, Serafina, Martino, Carmelinda, Botta, Angela, Salvi, Silvi, Moresi, Sascia, Del Sordo, Gelsomina, Lanzone, Antonio, De Carolis, Sara (ORCID:0000-0002-5160-7609), Ferrazzani, Sergio (ORCID:0000-0001-7382-2951), Lanzone, Antonio (ORCID:0000-0003-4119-414X), Sheiner, E. and Yogev, Y., De Carolis, Sara, Di Pasquo, Elvira, Ferrazzani, Sergio, Garofalo, Serafina, Martino, Carmelinda, Botta, Angela, Salvi, Silvi, Moresi, Sascia, Del Sordo, Gelsomina, Lanzone, Antonio, De Carolis, Sara (ORCID:0000-0002-5160-7609), Ferrazzani, Sergio (ORCID:0000-0001-7382-2951), and Lanzone, Antonio (ORCID:0000-0003-4119-414X)

Abstract

[No abstract available]

Published
2014

31. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Associations With Neonatal Anthropometrics

Author

Metzger, BE, Lowe, LP, Dyer, AR, Trimble, ER, Sheridan, B, Hod, M, Chen, R, Yogev, Y, Coustan, DR, Catalano, PM, Giles, W, Lowe, J, Hadden, DR, Persson, B, Oats, JJN, Metzger, BE, Lowe, LP, Dyer, AR, Trimble, ER, Sheridan, B, Hod, M, Chen, R, Yogev, Y, Coustan, DR, Catalano, PM, Giles, W, Lowe, J, Hadden, DR, Persson, B, and Oats, JJN

Abstract

OBJECTIVE: To examine associations of neonatal adiposity with maternal glucose levels and cord serum C-peptide in a multicenter multinational study, the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study, thereby assessing the Pederson hypothesis linking maternal glycemia and fetal hyperinsulinemia to neonatal adiposity. RESEARCH DESIGN AND METHODS: Eligible pregnant women underwent a standard 75-g oral glucose tolerance test between 24 and 32 weeks gestation (as close to 28 weeks as possible). Neonatal anthropometrics and cord serum C-peptide were measured. Associations of maternal glucose and cord serum C-peptide with neonatal adiposity (sum of skin folds >90th percentile or percent body fat >90th percentile) were assessed using multiple logistic regression analyses, with adjustment for potential confounders, including maternal age, parity, BMI, mean arterial pressure, height, gestational age at delivery, and the baby's sex. RESULTS: Among 23,316 HAPO Study participants with glucose levels blinded to caregivers, cord serum C-peptide results were available for 19,885 babies and skin fold measurements for 19,389. For measures of neonatal adiposity, there were strong statistically significant gradients across increasing levels of maternal glucose and cord serum C-peptide, which persisted after adjustment for potential confounders. In fully adjusted continuous variable models, odds ratios ranged from 1.35 to 1.44 for the two measures of adiposity for fasting, 1-h, and 2-h plasma glucose higher by 1 SD. CONCLUSIONS: These findings confirm the link between maternal glucose and neonatal adiposity and suggest that the relationship is mediated by fetal insulin production and that the Pedersen hypothesis describes a basic biological relationship influencing fetal growth.

Published
2009

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