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7. Clinical outcomes in the biomarkers of ketamine (Bio-K) study of open-label IV ketamine for refractory depression

Author

Parikh, Sagar V., Vande Voort, Jennifer L., Yocum, Anastasia K., Achtyes, Eric, Goes, Fernando S., Nykamp, Louis, Singh, Balwinder, Lopez-Vives, Daniela, Sera, Cortney E., Maixner, Daniel, Tarnal, Vijay, Severe, Jennifer, Bartek, Steven, Tye, Susannah J., Rico, Jose, Stoppel, Cynthia J., Becerra, Alexis, Smart, LeAnn, Miller, Christina R., Frye, Mark A., Greden, John F., and Bobo, William V.

Published
2024
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18. KRAS Engages AGO2 to Enhance Cellular Transformation

Author

Shankar, Sunita, Pitchiaya, Sethuramasundaram, Malik, Rohit, Kothari, Vishal, Hosono, Yasuyuki, Yocum, Anastasia K, Gundlapalli, Harika, White, Yasmine, Firestone, Ari, Cao, Xuhong, Dhanasekaran, Saravana M, Stuckey, Jeanne A, Bollag, Gideon, Shannon, Kevin, Walter, Nils G, Kumar-Sinha, Chandan, and Chinnaiyan, Arul M

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cancer, Aetiology, 2.1 Biological and endogenous factors, Animals, Argonaute Proteins, Base Sequence, Carboxypeptidases, Cell Transformation, Neoplastic, Endoplasmic Reticulum, Gene Expression Regulation, Neoplastic, Gene Silencing, Humans, Mice, MicroRNAs, Molecular Sequence Data, Mutation, NIH 3T3 Cells, Phosphatidylinositol 3-Kinases, Protein Binding, Proto-Oncogene Proteins p21(ras), RNA, Small Interfering, Transgenes, Argonaute 2, EIF2C2, KRAS, RNA silencing, cancer, Medical Physiology, Biological sciences
Abstract

Oncogenic mutations in RAS provide a compelling yet intractable therapeutic target. Using co-immunoprecipitation mass spectrometry, we uncovered an interaction between RAS and Argonaute 2 (AGO2). Endogenously, RAS and AGO2 co-sediment and co-localize in the endoplasmic reticulum. The AGO2 N-terminal domain directly binds the Switch II region of KRAS, agnostic of nucleotide (GDP/GTP) binding. Functionally, AGO2 knockdown attenuates cell proliferation in mutant KRAS-dependent cells and AGO2 overexpression enhances KRAS(G12V)-mediated transformation. Using AGO2-/- cells, we demonstrate that the RAS-AGO2 interaction is required for maximal mutant KRAS expression and cellular transformation. Mechanistically, oncogenic KRAS attenuates AGO2-mediated gene silencing. Overall, the functional interaction with AGO2 extends KRAS function beyond its canonical role in signaling.

Published
2016

19. Clinical outcomes in the biomarkers of ketamine (Bio-K) study of open-label IV ketamine for refractory depression

Author

Parikh, Sagar V., primary, Vande Voort, Jennifer L., additional, Yocum, Anastasia K., additional, Achtyes, Eric, additional, Goes, Fernando S., additional, Nykamp, Louis, additional, Singh, Balwinder, additional, Lopez-Vives, Daniela, additional, Sera, Cortney E., additional, Maixner, Daniel, additional, Tarnal, Vijay, additional, Severe, Jennifer, additional, Bartek, Steven, additional, Tye, Susannah J., additional, Rico, Jose, additional, Stoppel, Cynthia J., additional, Beccera, Alexis, additional, Smart, LeAnn, additional, Miller, Christina R., additional, Frye, Mark A., additional, Greden, John F., additional, and Bobo, William V., additional

Published
2023
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22. The Human Phenotype Ontology in 2024: phenotypes around the world

Author

Gargano, Michael A, primary, Matentzoglu, Nicolas, additional, Coleman, Ben, additional, Addo-Lartey, Eunice B, additional, Anagnostopoulos, Anna V, additional, Anderton, Joel, additional, Avillach, Paul, additional, Bagley, Anita M, additional, Bakštein, Eduard, additional, Balhoff, James P, additional, Baynam, Gareth, additional, Bello, Susan M, additional, Berk, Michael, additional, Bertram, Holli, additional, Bishop, Somer, additional, Blau, Hannah, additional, Bodenstein, David F, additional, Botas, Pablo, additional, Boztug, Kaan, additional, Čady, Jolana, additional, Callahan, Tiffany J, additional, Cameron, Rhiannon, additional, Carbon, Seth J, additional, Castellanos, Francisco, additional, Caufield, J Harry, additional, Chan, Lauren E, additional, Chute, Christopher G, additional, Cruz-Rojo, Jaime, additional, Dahan-Oliel, Noémi, additional, Davids, Jon R, additional, de Dieuleveult, Maud, additional, de Souza, Vinicius, additional, de Vries, Bert B A, additional, de Vries, Esther, additional, DePaulo, J Raymond, additional, Derfalvi, Beata, additional, Dhombres, Ferdinand, additional, Diaz-Byrd, Claudia, additional, Dingemans, Alexander J M, additional, Donadille, Bruno, additional, Duyzend, Michael, additional, Elfeky, Reem, additional, Essaid, Shahim, additional, Fabrizzi, Carolina, additional, Fico, Giovanna, additional, Firth, Helen V, additional, Freudenberg-Hua, Yun, additional, Fullerton, Janice M, additional, Gabriel, Davera L, additional, Gilmour, Kimberly, additional, Giordano, Jessica, additional, Goes, Fernando S, additional, Moses, Rachel Gore, additional, Green, Ian, additional, Griese, Matthias, additional, Groza, Tudor, additional, Gu, Weihong, additional, Guthrie, Julia, additional, Gyori, Benjamin, additional, Hamosh, Ada, additional, Hanauer, Marc, additional, Hanušová, Kateřina, additional, He, Yongqun (Oliver), additional, Hegde, Harshad, additional, Helbig, Ingo, additional, Holasová, Kateřina, additional, Hoyt, Charles Tapley, additional, Huang, Shangzhi, additional, Hurwitz, Eric, additional, Jacobsen, Julius O B, additional, Jiang, Xiaofeng, additional, Joseph, Lisa, additional, Keramatian, Kamyar, additional, King, Bryan, additional, Knoflach, Katrin, additional, Koolen, David A, additional, Kraus, Megan L, additional, Kroll, Carlo, additional, Kusters, Maaike, additional, Ladewig, Markus S, additional, Lagorce, David, additional, Lai, Meng-Chuan, additional, Lapunzina, Pablo, additional, Laraway, Bryan, additional, Lewis-Smith, David, additional, Li, Xiarong, additional, Lucano, Caterina, additional, Majd, Marzieh, additional, Marazita, Mary L, additional, Martinez-Glez, Victor, additional, McHenry, Toby H, additional, McInnis, Melvin G, additional, McMurry, Julie A, additional, Mihulová, Michaela, additional, Millett, Caitlin E, additional, Mitchell, Philip B, additional, Moslerová, Veronika, additional, Narutomi, Kenji, additional, Nematollahi, Shahrzad, additional, Nevado, Julian, additional, Nierenberg, Andrew A, additional, Čajbiková, Nikola Novák, additional, Nurnberger, John I, additional, Ogishima, Soichi, additional, Olson, Daniel, additional, Ortiz, Abigail, additional, Pachajoa, Harry, additional, Perez de Nanclares, Guiomar, additional, Peters, Amy, additional, Putman, Tim, additional, Rapp, Christina K, additional, Rath, Ana, additional, Reese, Justin, additional, Rekerle, Lauren, additional, Roberts, Angharad M, additional, Roy, Suzy, additional, Sanders, Stephan J, additional, Schuetz, Catharina, additional, Schulte, Eva C, additional, Schulze, Thomas G, additional, Schwarz, Martin, additional, Scott, Katie, additional, Seelow, Dominik, additional, Seitz, Berthold, additional, Shen, Yiping, additional, Similuk, Morgan N, additional, Simon, Eric S, additional, Singh, Balwinder, additional, Smedley, Damian, additional, Smith, Cynthia L, additional, Smolinsky, Jake T, additional, Sperry, Sarah, additional, Stafford, Elizabeth, additional, Stefancsik, Ray, additional, Steinhaus, Robin, additional, Strawbridge, Rebecca, additional, Sundaramurthi, Jagadish Chandrabose, additional, Talapova, Polina, additional, Tenorio Castano, Jair A, additional, Tesner, Pavel, additional, Thomas, Rhys H, additional, Thurm, Audrey, additional, Turnovec, Marek, additional, van Gijn, Marielle E, additional, Vasilevsky, Nicole A, additional, Vlčková, Markéta, additional, Walden, Anita, additional, Wang, Kai, additional, Wapner, Ron, additional, Ware, James S, additional, Wiafe, Addo A, additional, Wiafe, Samuel A, additional, Wiggins, Lisa D, additional, Williams, Andrew E, additional, Wu, Chen, additional, Wyrwoll, Margot J, additional, Xiong, Hui, additional, Yalin, Nefize, additional, Yamamoto, Yasunori, additional, Yatham, Lakshmi N, additional, Yocum, Anastasia K, additional, Young, Allan H, additional, Yüksel, Zafer, additional, Zandi, Peter P, additional, Zankl, Andreas, additional, Zarante, Ignacio, additional, Zvolský, Miroslav, additional, Toro, Sabrina, additional, Carmody, Leigh C, additional, Harris, Nomi L, additional, Munoz-Torres, Monica C, additional, Danis, Daniel, additional, Mungall, Christopher J, additional, Köhler, Sebastian, additional, Haendel, Melissa A, additional, and Robinson, Peter N, additional

Published
2023
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23. Predictors of Functional Impairment in Bipolar Disorder: Results From 13 Cohorts From Seven Countries by the Global Bipolar Cohort Collaborative

Author

Burdick, Katherine E., primary, Millett, Caitlin E., additional, Yocum, Anastasia K., additional, Altimus, Cara M., additional, Andreassen, Ole A., additional, Aubin, Valerie, additional, Belzeaux, Raoul, additional, Berk, Michael, additional, Biernacka, Joanna M., additional, Blumberg, Hilary P., additional, Cleare, Anthony J., additional, Diaz-Byrd, Claudia, additional, Dubertret, Caroline, additional, Etain, Bruno, additional, Eyler, Lisa T., additional, Forester, Brent P., additional, Fullerton, Janice M., additional, Frye, Mark A., additional, Gard, Sébastien, additional, Godin, Ophelia, additional, Haffen, Emmanuel, additional, Klaus, Federica, additional, Lagerberg, Trine Vik, additional, Leboyer, Marion, additional, Martinez-Aran, Anabel, additional, McElroy, Susan, additional, Mitchell, Philip B., additional, Olie, Emilie, additional, Olorunfemi, Phebe, additional, Passerieux, Christine, additional, Peters, Amy T., additional, Pham, Daniel L., additional, Polosan, Mircea, additional, Potter, Julia R., additional, Sajatovic, Martha, additional, Samalin, Ludovic, additional, Schwan, Raymund, additional, Shanahan, Megan, additional, Solé, Brisa, additional, Strawbridge, Rebecca, additional, Stuart, Amanda L., additional, Torres, Ivan, additional, Ueland, Torrill, additional, Vieta, Eduard, additional, Williams, Lana J., additional, Wrobel, Anna L., additional, Yatham, Lakshmi N., additional, Young, Allan H., additional, Nierenberg, Andrew A., additional, and McInnis, Melvin G., additional

Published
2023
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24. Cohort Profile Update: The Heinz C. Prechter Longitudinal Study of Bipolar Disorder

Author

Yocum, Anastasia K, primary, Anderau, Steve, additional, Bertram, Holli, additional, Burgess, Helen J, additional, Cochran, Amy L, additional, Deldin, Patricia J, additional, Evans, Simon J, additional, Han, Peisong, additional, Jenkins, Paul M, additional, Kaur, Ravleen, additional, Langenecker, Scott A, additional, Marshall, David F, additional, Mower Provost, Emily, additional, Sue O’Shea, K, additional, Ryan, Kelly A, additional, Sperry, Sarah H, additional, Smith, Shawna N, additional, Tso, Ivy F, additional, Versha, Kritika M, additional, Wright, Brittany M, additional, Zöllner, Sebastian, additional, and McInnis, Melvin G, additional

Published
2023
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25. Patterns of pharmacotherapy for bipolar disorder: A GBC survey.

Author

Singh, Balwinder, Yocum, Anastasia K., Strawbridge, Rebecca, Burdick, Katherine E., Millett, Caitlin E., Peters, Amy T., Sperry, Sarah H., Fico, Giovanna, Vieta, Eduard, Verdolini, Norma, Godin, Ophelia, Leboyer, Marion, Etain, Bruno, Tso, Ivy F., Coombes, Brandon J., McInnis, Melvin G., Nierenberg, Andrew A., Young, Allan H., Ashton, Melanie M., and Berk, Michael

Subjects
*DRUG therapy, *BIPOLAR disorder, *LITHIUM carbonate, *ANTICONVULSANTS, *MOOD stabilizers
Abstract

Objectives: To understand treatment practices for bipolar disorders (BD), this study leveraged the Global Bipolar Cohort collaborative network to investigate pharmacotherapeutic treatment patterns in multiple cohorts of well‐characterized individuals with BD in North America, Europe, and Australia. Methods: Data on pharmacotherapy, demographics, diagnostic subtypes, and comorbidities were provided from each participating cohort. Individual site and regional pooled proportional meta‐analyses with generalized linear mixed methods were conducted to identify prescription patterns. Results: This study included 10,351 individuals from North America (n = 3985), Europe (n = 3822), and Australia (n = 2544). Overall, participants were predominantly female (60%) with BD‐I (60%; vs. BD‐II = 33%). Cross‐sectionally, mood‐stabilizing anticonvulsants (44%), second‐generation antipsychotics (42%), and antidepressants (38%) were the most prescribed medications. Lithium was prescribed in 29% of patients, primarily in the Australian (31%) and European (36%) cohorts. First‐generation antipsychotics were prescribed in 24% of the European versus 1% in the North American cohort. Antidepressant prescription rates were higher in BD‐II (47%) compared to BD‐I (35%). Major limitations were significant differences among cohorts based on inclusion/exclusion criteria, data source, and time/year of enrollment into cohort. Conclusions: Mood‐stabilizing anticonvulsants, second‐generation antipsychotics, and antidepressants were the most prescribed medications suggesting prescription patterns that are not necessarily guideline concordant. Significant differences exist in the prescription practices across different geographic regions, especially the underutilization of lithium in the North American cohorts and the higher utilization of first‐generation antipsychotics in the European cohorts. There is a need to conduct future longitudinal studies to further explore these differences and their impact on outcomes, and to inform and implement evidence‐based guidelines to help improve treatment practices in BD. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Interpersonal Trauma and Depression Severity Among Individuals With Bipolar Disorder

Author

Wrobel, Anna L., primary, Russell, Samantha E., additional, Jayasinghe, Anuradhi, additional, Lotfaliany, Mojtaba, additional, Turner, Alyna, additional, Dean, Olivia M., additional, Cotton, Sue M., additional, Diaz-Byrd, Claudia, additional, Yocum, Anastasia K., additional, Duval, Elizabeth R., additional, Ehrlich, Tobin J., additional, Marshall, David F., additional, Berk, Michael, additional, and McInnis, Melvin G., additional

Published
2023
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27. Uncovering circadian rhythm disruptions of synaptic proteome signaling in prefrontal cortex and nucleus accumbens associated with opioid use disorder

Author

Puig, Stephanie, primary, Xue, Xiangning, additional, Salisbury, Ryan, additional, Shelton, Micah A, additional, Kim, Sam-Moon, additional, Hildebrand, Mariah A, additional, Glausier, Jill R, additional, Freyberg, Zachary, additional, Tseng, George C, additional, Yocum, Anastasia K, additional, Lewis, David A, additional, Seney, Marianne L, additional, MacDonald, Matthew L, additional, and Logan, Ryan W, additional

Published
2023
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28. Data from Characterization of KRAS Rearrangements in Metastatic Prostate Cancer

Author

Wang, Xiao-Song, primary, Shankar, Sunita, primary, Dhanasekaran, Saravana M., primary, Ateeq, Bushra, primary, Sasaki, Atsuo T., primary, Jing, Xiaojun, primary, Robinson, Daniel, primary, Cao, Qi, primary, Prensner, John R., primary, Yocum, Anastasia K., primary, Wang, Rui, primary, Fries, Daniel F., primary, Han, Bo, primary, Asangani, Irfan A., primary, Cao, Xuhong, primary, Li, Yong, primary, Omenn, Gilbert S., primary, Pflueger, Dorothee, primary, Gopalan, Anuradha, primary, Reuter, Victor E., primary, Kahoud, Emily Rose, primary, Cantley, Lewis C., primary, Rubin, Mark A., primary, Palanisamy, Nallasivam, primary, Varambally, Sooryanarayana, primary, and Chinnaiyan, Arul M., primary

Published
2023
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29. Supplementary Methods and Data (posted 7/5/2011) from Characterization of KRAS Rearrangements in Metastatic Prostate Cancer

Author

Wang, Xiao-Song, primary, Shankar, Sunita, primary, Dhanasekaran, Saravana M., primary, Ateeq, Bushra, primary, Sasaki, Atsuo T., primary, Jing, Xiaojun, primary, Robinson, Daniel, primary, Cao, Qi, primary, Prensner, John R., primary, Yocum, Anastasia K., primary, Wang, Rui, primary, Fries, Daniel F., primary, Han, Bo, primary, Asangani, Irfan A., primary, Cao, Xuhong, primary, Li, Yong, primary, Omenn, Gilbert S., primary, Pflueger, Dorothee, primary, Gopalan, Anuradha, primary, Reuter, Victor E., primary, Kahoud, Emily Rose, primary, Cantley, Lewis C., primary, Rubin, Mark A., primary, Palanisamy, Nallasivam, primary, Varambally, Sooryanarayana, primary, and Chinnaiyan, Arul M., primary

Published
2023
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30. Supplementary Methods, Figures, Tables, and References from Characterization of KRAS Rearrangements in Metastatic Prostate Cancer

Author

Wang, Xiao-Song, primary, Shankar, Sunita, primary, Dhanasekaran, Saravana M., primary, Ateeq, Bushra, primary, Sasaki, Atsuo T., primary, Jing, Xiaojun, primary, Robinson, Daniel, primary, Cao, Qi, primary, Prensner, John R., primary, Yocum, Anastasia K., primary, Wang, Rui, primary, Fries, Daniel F., primary, Han, Bo, primary, Asangani, Irfan A., primary, Cao, Xuhong, primary, Li, Yong, primary, Omenn, Gilbert S., primary, Pflueger, Dorothee, primary, Gopalan, Anuradha, primary, Reuter, Victor E., primary, Kahoud, Emily Rose, primary, Cantley, Lewis C., primary, Rubin, Mark A., primary, Palanisamy, Nallasivam, primary, Varambally, Sooryanarayana, primary, and Chinnaiyan, Arul M., primary

Published
2023
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32. Childhood trauma and depressive symptoms in bipolar disorder: A network analysis

Author

Wrobel, Anna L., primary, Cotton, Sue M., additional, Jayasinghe, Anuradhi, additional, Diaz‐Byrd, Claudia, additional, Yocum, Anastasia K., additional, Turner, Alyna, additional, Dean, Olivia M., additional, Russell, Samantha E., additional, Duval, Elizabeth R., additional, Ehrlich, Tobin J., additional, Marshall, David F., additional, Berk, Michael, additional, and McInnis, Melvin G., additional

Published
2023
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33. Personality traits as mediators of the relationship between childhood trauma and depression severity in bipolar disorder: A structural equation model.

Author

Wrobel, Anna L, Russell, Samantha E, Jayasinghe, Anuradhi, Kavanagh, Bianca E, Lotfaliany, Mojtaba, Turner, Alyna, Dean, Olivia M, Cotton, Sue M, Diaz-Byrd, Claudia, Yocum, Anastasia K, Duval, Elizabeth R, Ehrlich, Tobin J, Marshall, David F, Berk, Michael, and McInnis, Melvin G

Subjects
ADVERSE childhood experiences, PERSONALITY, STRUCTURAL equation modeling, CONFIDENCE intervals, SEVERITY of illness index, MENTAL depression, DESCRIPTIVE statistics, HAMILTON Depression Inventory, QUESTIONNAIRES, RESEARCH funding, PERSONALITY tests, BIPOLAR disorder, SECONDARY analysis, EVALUATION
Abstract

Background: Childhood trauma is negatively associated with depression severity in bipolar disorder; however, the underlying mechanisms remain unclear. We investigated whether personality traits (neuroticism, extraversion, openness, agreeableness, conscientiousness) mediate the relationship between childhood trauma and the severity of bipolar depression. Methods: Data from 209 individuals with bipolar disorder recruited for the Prechter Longitudinal Study of Bipolar Disorder were analysed. Using structural equation modelling, we examined the direct and indirect associations between childhood trauma (Childhood Trauma Questionnaire) and depression severity (Hamilton Depression Rating Scale) – with the personality traits (NEO Personality Inventory–Revised) as mediators. Results: The direct effect of childhood trauma on depression severity (standardised β = 0.32, 95% bootstrap confidence interval [CI] = 0.20–0.45, p < 0.001) and the indirect effect via neuroticism (standardised β = 0.03, 95% bootstrap CI [0.002, 0.07], p = 0.039) were significant; supporting a partial mediation model. The indirect effect accounted for 9% of the total effect of childhood trauma on depression severity (standardised β = 0.09, 95% bootstrap CI [0.002, 0.19], p = 0.046). The final model had a good fit with the data (comparative fit index = 0.96; root mean square error of approximation = 0.05, 90% CI = [0.02, 0.07]). Conclusion: Personality traits may be relevant psychological mediators that link childhood trauma to a more severe clinical presentation of bipolar depression. Consequently, a person's personality structure may be a crucial operative factor to incorporate in therapeutic plans when treating individuals with bipolar disorder who report a history of childhood trauma. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Personality traits as mediators of the relationship between childhood trauma and depression severity in bipolar disorder: A structural equation model

Author

Wrobel, Anna L, primary, Russell, Samantha E, additional, Jayasinghe, Anuradhi, additional, Kavanagh, Bianca E, additional, Lotfaliany, Mojtaba, additional, Turner, Alyna, additional, Dean, Olivia M, additional, Cotton, Sue M, additional, Diaz-Byrd, Claudia, additional, Yocum, Anastasia K, additional, Duval, Elizabeth R, additional, Ehrlich, Tobin J, additional, Marshall, David F, additional, Berk, Michael, additional, and McInnis, Melvin G, additional

Published
2022
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38. Targeting the MLL complex in castration-resistant prostate cancer

Author

Malik, Rohit, Khan, Amjad P., Asangani, Irfan A., Cieslik, Marcin, Prensner, John R., Wang, Xiaoju, Iyer, Matthew K., Jiang, Xia, Borkin, Dmitry, Escara-Wilke, June, Stender, Rachell, Wu, Yi-Mi, Niknafs, Yashar S., Jing, Xiaojun, Qiao, Yuanyuan, Palanisamy, Nallasivam, Kunju, Lakshmi P., Krishnamurthy, Pranathi M., Yocum, Anastasia K., Mellacheruvu, Dattatreya, Nesvizhskii, Alexey I., Cao, Xuhong, Dhanasekaran, Saravana M., Feng, Felix Y., Grembecka, Jolanta, Cierpicki, Tomasz, and Chinnaiyan, Arul M.

Subjects
Oncology, Experimental, Prostate cancer -- Development and progression -- Care and treatment, Drug targeting -- Research, Cancer -- Research, Biological sciences, Health
Abstract

Resistance to androgen deprivation therapies and increased androgen receptor (AR) activity are major drivers of castrationresistant prostate cancer (CRPC). Although prior work has focused on targeting AR directly, co-activators of AR signaling, which may represent new therapeutic targets, are relatively underexplored. Here we demonstrate that the mixed-lineage leukemia protein (MLL) complex, a well-known driver of MLL fusion-positive leukemia, acts as a co-activator of AR signaling. AR directly interacts with the MLL complex via the menin-MLL subunit. Menin expression is higher in CRPC than in both hormone-naive prostate cancer and benign prostate tissue, and high menin expression correlates with poor overall survival of individuals diagnosed with prostate cancer. Treatment with a small-molecule inhibitor of menin-MLL interaction blocks AR signaling and inhibits the growth of castration-resistant tumors in vivo in mice. Taken together, this work identifies the MLL complex as a crucial co-activator of AR and a potential therapeutic target in advanced prostate cancer., For prostate cancer, androgen deprivation therapies are front-line treatments, in addition to surgery and radiotherapy, for patients with high-risk localized disease, and second-generation anti-androgens such as abiraterone and enzalutamide have [...]

Published
2015
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40. Predictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative

Author

Burdick, Katherine E., primary, Millett, Caitlin E., additional, Yocum, Anastasia K., additional, Altimus, Cara M., additional, Andreassen, Ole A., additional, Aubin, Valerie, additional, Belzeaux, Raoul, additional, Berk, Michael, additional, Biernacka, Joanna M., additional, Blumberg, Hilary P., additional, Cleare, Anthony J., additional, Diaz‐Byrd, Claudia, additional, Dubertret, Caroline, additional, Etain, Bruno, additional, Eyler, Lisa T., additional, Forester, Brent P., additional, Fullerton, Janice M., additional, Frye, Mark A., additional, Gard, Sébastien, additional, Godin, Ophelia, additional, Haffen, Emmanuel, additional, Klaus, Federica, additional, Lagerberg, Trine Vik, additional, Leboyer, Marion, additional, Martinez‐Aran, Anabel, additional, McElroy, Susan, additional, Mitchell, Philip B., additional, Olie, Emilie, additional, Olorunfemi, Phebe, additional, Passerieux, Christine, additional, Peters, Amy T., additional, Pham, Daniel L., additional, Polosan, Mircea, additional, Potter, Julia R., additional, Sajatovic, Martha, additional, Samalin, Ludovic, additional, Schwan, Raymund, additional, Shanahan, Megan, additional, Solé, Brisa, additional, Strawbridge, Rebecca, additional, Stuart, Amanda L., additional, Torres, Ivan, additional, Ueland, Torrill, additional, Vieta, Eduard, additional, Williams, Lana J., additional, Wrobel, Anna L., additional, Yatham, Lakshmi N., additional, Young, Allan H., additional, Nierenberg, Andrew A., additional, and McInnis, Melvin G., additional

Published
2022
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41. Attachment insecurity partially mediates the relationship between childhood trauma and depression severity in bipolar disorder

Author

Wrobel, Anna L., primary, Russell, Samantha E., additional, Jayasinghe, Anuradhi, additional, Lotfaliany, Mojtaba, additional, Turner, Alyna, additional, Dean, Olivia M., additional, Cotton, Sue M., additional, Diaz‐Byrd, Claudia, additional, Yocum, Anastasia K., additional, Duval, Elizabeth R., additional, Ehrlich, Tobin J., additional, Marshall, David F., additional, Berk, Michael, additional, and McInnis, Melvin G., additional

Published
2022
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42. sj-docx-1-anp-10.1177_00048674221115644 – Supplemental material for Personality traits as mediators of the relationship between childhood trauma and depression severity in bipolar disorder: A structural equation model

Author

Wrobel, Anna L, Russell, Samantha E, Jayasinghe, Anuradhi, Kavanagh, Bianca E, Lotfaliany, Mojtaba, Turner, Alyna, Dean, Olivia M, Cotton, Sue M, Diaz-Byrd, Claudia, Yocum, Anastasia K, Duval, Elizabeth R, Ehrlich, Tobin J, Marshall, David F, Berk, Michael, and McInnis, Melvin G

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), Neuroscience
Abstract

Supplemental material, sj-docx-1-anp-10.1177_00048674221115644 for Personality traits as mediators of the relationship between childhood trauma and depression severity in bipolar disorder: A structural equation model by Anna L Wrobel, Samantha E Russell, Anuradhi Jayasinghe, Bianca E Kavanagh, Mojtaba Lotfaliany, Alyna Turner, Olivia M Dean, Sue M Cotton, Claudia Diaz-Byrd, Anastasia K Yocum, Elizabeth R Duval, Tobin J Ehrlich, David F Marshall, Michael Berk and Melvin G McInnis in Australian & New Zealand Journal of Psychiatry

Published
2022
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43. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer

Author

Brenner, J. Chad, Ateeq, Bushra, Li, Yong, Yocum, Anastasia K., Cao, Qi, Asangani, Irfan A., Patel, Sonam, Wang, Xiaoju, Liang, Hallie, Yu, Jindan, Palanisamy, Nallasivam, Siddiqui, Javed, Yan, Wei, Cao, Xuhong, Mehra, Rohit, Sabolch, Aaron, Basrur, Venkatesha, Lonigro, Robert J., Yang, Jun, Tomlins, Scott A., Maher, Christopher A., Elenitoba-Johnson, Kojo S.J., Hussain, Maha, Navone, Nora M., Pienta, Kenneth J., Varambally, Sooryanarayana, Feng, Felix Y., and Chinnaiyan, Arul M.

Published
2011
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47. Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders

Author

Ugras, Scott, primary, Daniels, Malcolm J., additional, Fazelinia, Hossein, additional, Gould, Neal S., additional, Yocum, Anastasia K., additional, Luk, Kelvin C., additional, Luna, Esteban, additional, Ding, Hua, additional, McKennan, Chris, additional, Seeholzer, Steven, additional, Martinez, Dan, additional, Evans, Perry, additional, Brown, Daniel, additional, Duda, John E., additional, and Ischiropoulos, Harry, additional

Published
2018
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48. Abstract LB-008: KRAS engages AGO2 to enhance cellular transformation

Author

Shankar, Sunita, primary, Pitchiaya, Sethuramasundaram, additional, Malik, Rohit, additional, Kothari, Vishal, additional, Hosono, Yasuyuki, additional, Yocum, Anastasia K., additional, Gundlapalli, Harika, additional, White, Yasmine, additional, Firestone, Ari, additional, Cao, Xuhong, additional, Dhanasekaran, Saravana M., additional, Stuckey, Jeanne, additional, Bollag, Gideon, additional, Shannon, Kevin, additional, Walter, Nils, additional, Kumar-Sinha, Chandan, additional, and Chinnaiyan, Arul M., additional

Published
2016
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50. Bioinformatics

Author

Reinert, Knut, primary, Conrad, Tim, additional, Kohlbacher, Oliver, additional, Yocum, Anastasia K., additional, Ulintz, Peter J., additional, and Andrews, Philip C., additional

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