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8 results on '"Yockey, Lynne"'

1. Common Severe Infections in Chronic Granulomatous Disease

Author

Marciano, Beatriz E., Spalding, Christine, Fitzgerald, Alan, Mann, Daphne, Brown, Thomas, Osgood, Sharon, Yockey, Lynne, Darnell, Dirk N., Barnhart, Lisa, Daub, Janine, Boris, Lisa, Rump, Amy P., Anderson, Victoria L., Haney, Carissa, Kuhns, Douglas B., Rosenzweig, Sergio D., Kelly, Corin, Zelazny, Adrian, Mason, Tamika, See DeRavin, Suk, Kang, Elizabeth, Gallin, John I., Malech, Harry L., Olivier, Kenneth N., Uzel, Gulbu, Freeman, Alexandra F., Heller, Theo, Zerbe, Christa S., and Holland, Steven M.

Published
2015

2. X-linked carriers of chronic granulomatous disease: Illness, lyonization, and stability

Author

Marciano, Beatriz E., Zerbe, Christa S., Falcone, Liana E., Ding, Li, DeRavin, Suk See, Daub, Janine, Kreuzburg, Samantha, Yockey, Lynne, Hunsberger, Sally, Foruraghi, Ladan, Barnhart, Lisa A., Matharu, Kabir, Anderson, Victoria, Darnell, Dirk N., Frein, Cathleen, Fink, Danielle L., Lau, Karen P., Priel, Debra Long A., Gallin, John I., Malech, Harry L., Uzel, Gulbu, Freeman, Alexandra F., Kuhns, Douglas B., Rosenzweig, Sergio D., and Holland, Steven M.

Published
2018
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3. Tuberculous Meningitis in a Patient with Cushing's Disease: Glucocorticoid-mediated Immunosuppression: Case Report, and Review of the Literature

Author

Chatain, Gregoire, Mehta, Gautam, Nieman, Lynnette, Sharma, Susmeeta, Yuditskaya, Susan, Chen, Ray, Yockey, Lynne, Holland, Steven, and Chittiboina, Prashant

Subjects
Meningeal tuberculosis -- Diagnosis -- Care and treatment, Immunosuppression -- Patient outcomes, Glucocorticoids -- Usage, Cushing syndrome -- Diagnosis -- Care and treatment, Mortality, Pituitary tumors, Etiology (Medicine), Hormones, Corticotropin, Adenoma, Meningitis, Pituitary hormones, Medical research, Immunotherapy, Health
Abstract

Byline: Gregoire. Chatain, Gautam. Mehta, Lynnette. Nieman, Susmeeta. Sharma, Susan. Yuditskaya, Ray. Chen, Lynne. Yockey, Steven. Holland, Prashant. Chittiboina Sir, Chronic exposure to excess glucocorticoids leads to Cushing's syndrome (CS), [...]

Published
2019

5. Redefined clinical features and diagnostic criteria in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy

Author

Ferre, Elise M.N., primary, Rose, Stacey R., additional, Rosenzweig, Sergio D., additional, Burbelo, Peter D., additional, Romito, Kimberly R., additional, Niemela, Julie E., additional, Rosen, Lindsey B., additional, Break, Timothy J., additional, Gu, Wenjuan, additional, Hunsberger, Sally, additional, Browne, Sarah K., additional, Hsu, Amy P., additional, Rampertaap, Shakuntala, additional, Swamydas, Muthulekha, additional, Collar, Amanda L., additional, Kong, Heidi H., additional, Lee, Chyi-Chia Richard, additional, Chascsa, David, additional, Simcox, Thomas, additional, Pham, Angela, additional, Bondici, Anamaria, additional, Natarajan, Mukil, additional, Monsale, Joseph, additional, Kleiner, David E., additional, Quezado, Martha, additional, Alevizos, Ilias, additional, Moutsopoulos, Niki M., additional, Yockey, Lynne, additional, Frein, Cathleen, additional, Soldatos, Ariane, additional, Calvo, Katherine R., additional, Adjemian, Jennifer, additional, Similuk, Morgan N., additional, Lang, David M., additional, Stone, Kelly D., additional, Uzel, Gulbu, additional, Kopp, Jeffrey B., additional, Bishop, Rachel J., additional, Holland, Steven M., additional, Olivier, Kenneth N., additional, Fleisher, Thomas A., additional, Heller, Theo, additional, Winer, Karen K., additional, and Lionakis, Michail S., additional

Published
2016
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6. CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System

Author

Drummond, Rebecca A., primary, Collar, Amanda L., additional, Swamydas, Muthulekha, additional, Rodriguez, Carlos A., additional, Lim, Jean K., additional, Mendez, Laura M., additional, Fink, Danielle L., additional, Hsu, Amy P., additional, Zhai, Bing, additional, Karauzum, Hatice, additional, Mikelis, Constantinos M., additional, Rose, Stacey R., additional, Ferre, Elise M. N., additional, Yockey, Lynne, additional, Lemberg, Kimberly, additional, Kuehn, Hye Sun, additional, Rosenzweig, Sergio D., additional, Lin, Xin, additional, Chittiboina, Prashant, additional, Datta, Sandip K., additional, Belhorn, Thomas H., additional, Weimer, Eric T., additional, Hernandez, Michelle L., additional, Hohl, Tobias M., additional, Kuhns, Douglas B., additional, and Lionakis, Michail S., additional

Published
2015
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7. Treatment With Anakinra, a Recombinant IL-1 Receptor Antagonist, Unlikely to Induce Lasting Remission in Patients With CGD Colitis

Author

Hahn, Katherine J, primary, Ho, Nancy, additional, Yockey, Lynne, additional, Kreuzberg, Samantha, additional, Daub, Janine, additional, Rump, Amy, additional, Marciano, Beatriz E, additional, Quezado, Martha, additional, Malech, Harry L, additional, Holland, Steven M, additional, Heller, Theo, additional, and Zerbe, Christa S, additional

Published
2015
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8. CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System

Author

Lionakis, Michail S., Datta, Sandip K., Chittiboina, Prashant, Karauzum, Hatice, Fink, Danielle L., Rosenzweig, Sergio D., Drummond, Rebecca A., Weimer, Eric T., Kuhns, Douglas B., Lim, Jean K., Mendez, Laura M., Belhorn, Thomas H., Yockey, Lynne, Ferre, Elise M. N., Mikelis, Constantinos M., Lemberg, Kimberly, Hernandez, Michelle L., Hsu, Amy P., Collar, Amanda L., Rose, Stacey R., Lin, Xin, Rodriguez, Carlos A., Hohl, Tobias M., Zhai, Bing, Kuehn, Hye Sun, and Swamydas, Muthulekha

Subjects
3. Good health
Abstract

Candida is the most common human fungal pathogen and causes systemic infections that require neutrophils for effective host defense. Humans deficient in the C-type lectin pathway adaptor protein CARD9 develop spontaneous fungal disease that targets the central nervous system (CNS). However, how CARD9 promotes protective antifungal immunity in the CNS remains unclear. Here, we show that a patient with CARD9 deficiency had impaired neutrophil accumulation and induction of neutrophil-recruiting CXC chemokines in the cerebrospinal fluid despite uncontrolled CNS Candida infection. We phenocopied the human susceptibility in Card9-/- mice, which develop uncontrolled brain candidiasis with diminished neutrophil accumulation. The induction of neutrophil-recruiting CXC chemokines is significantly impaired in infected Card9-/- brains, from both myeloid and resident glial cellular sources, whereas cell-intrinsic neutrophil chemotaxis is Card9-independent. Taken together, our data highlight the critical role of CARD9-dependent neutrophil trafficking into the CNS and provide novel insight into the CNS fungal susceptibility of CARD9-deficient humans.

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