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2. A network analysis of risk factors for suicide in Iraq/Afghanistan-era veterans

Author

Brancu, Mira, Beckham, Jean C., Calhoun, Patrick S., Dedert, Eric, Elbogen, Eric B., Fairbank, John A., Hurley, Robin A., Kilts, Jason D., Kimbrel, Nathan A., Kirby, Angela, Marx, Christine E., McDonald, Scott D., Moore, Scott D., Morey, Rajendra A., Naylor, Jennifer C., Rowland, Jared, Shura, Robert, Swinkels, Cindy, Szabo, Steven T., Taber, Katherine H., Tupler, Larry A., Van Voorhees, Elizabeth E., Yoash-Gantz, Ruth E., Graziano, Robert C., Aunon, Frances M., LoSavio, Stefanie T., and Dillon, Kirsten H.

Published
2021
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3. Amygdala Nuclei Volume and Shape in Military Veterans With Posttraumatic Stress Disorder

Author

Brancu, Mira, Beckham, Jean C., Calhoun, Patrick S., Dedert, Eric, Elbogen, Eric B., Fairbank, John A., Hurley, Robin A., Kilts, Jason D., Kimbrel, Nathan A., Kirby, Angela, Marx, Christine E., McDonald, Scott D., Moore, Scott D., Naylor, Jennifer C., Rowland, Jared, Swinkels, Cindy, Szabo, Steven T., Taber, Katherine H., Tupler, Larry A., van Voorhees, Elizabeth E., Yoash-Gantz, Ruth E., Morey, Rajendra A., Clarke, Emily K., Haswell, Courtney C., Phillips, Rachel D., Clausen, Ashley N., Mufford, Mary S., Saygin, Zeynep, Wagner, H. Ryan, and LaBar, Kevin S.

Published
2020
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6. Cannabis use disorder, anger, and violence in Iraq/Afghanistan-era veterans

Author

Brancu, Mira, Beckham, Jean C., Calhoun, Patrick S., Dedert, Eric, Elbogen, Eric B., Fairbank, John A., Hurley, Robin A., Kilts, Jason D., Kimbrel, Nathan A., Kirby, Angela, Marx, Christine E., McDonald, Scott D., Moore, Scott D., Morey, Rajendra A., Naylor, Jennifer C., Rowland, Jared, Shura, Robert, Swinkels, Cindy, Szabo, Steven T., Taber, Katherine H., Tupler, Larry A., Van Voorhees, Elizabeth E., Yoash-Gantz, Ruth E., and Dillon, Kirsten H.

Published
2021
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8. A network analysis of risk factors for suicide in Iraq/Afghanistan-era veterans

Author

Graziano, Robert C., primary, Aunon, Frances M., additional, LoSavio, Stefanie T., additional, Elbogen, Eric B., additional, Beckham, Jean C., additional, Dillon, Kirsten H., additional, Brancu, Mira, additional, Calhoun, Patrick S., additional, Dedert, Eric, additional, Fairbank, John A., additional, Hurley, Robin A., additional, Kilts, Jason D., additional, Kimbrel, Nathan A., additional, Kirby, Angela, additional, Marx, Christine E., additional, McDonald, Scott D., additional, Moore, Scott D., additional, Morey, Rajendra A., additional, Naylor, Jennifer C., additional, Rowland, Jared, additional, Shura, Robert, additional, Swinkels, Cindy, additional, Szabo, Steven T., additional, Taber, Katherine H., additional, Tupler, Larry A., additional, Van Voorhees, Elizabeth E., additional, and Yoash-Gantz, Ruth E., additional

Published
2021
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9. Cannabis use disorder, anger, and violence in Iraq/Afghanistan-era veterans

Author

Dillon, Kirsten H., primary, Van Voorhees, Elizabeth E., additional, Elbogen, Eric B., additional, Beckham, Jean C., additional, Calhoun, Patrick S., additional, Brancu, Mira, additional, Dedert, Eric, additional, Fairbank, John A., additional, Hurley, Robin A., additional, Kilts, Jason D., additional, Kimbrel, Nathan A., additional, Kirby, Angela, additional, Marx, Christine E., additional, McDonald, Scott D., additional, Moore, Scott D., additional, Morey, Rajendra A., additional, Naylor, Jennifer C., additional, Rowland, Jared, additional, Shura, Robert, additional, Swinkels, Cindy, additional, Szabo, Steven T., additional, Taber, Katherine H., additional, Tupler, Larry A., additional, and Yoash-Gantz, Ruth E., additional

Published
2021
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12. Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR

Author

Smith, Alicia K., Ratanatharathorn, Andrew, Maihofer, Adam X., Naviaux, Robert K., Aiello, Allison E., Amstadter, Ananda B., Ashley-Koch, Allison E., Baker, Dewleen G., Beckham, Jean C., Boks, Marco P., Bromet, Evelyn, Dennis, Michelle, Galea, Sandro, Garrett, Melanie E., Geuze, Elbert, Guffanti, Guia, Hauser, Michael A., Katrinli, Seyma, Kilaru, Varun, Kessler, Ronald C., Kimbrel, Nathan A., Koenen, Karestan C., Kuan, Pei Fen, Li, Kefeng, Logue, Mark W., Lori, Adriana, Luft, Benjamin J., Miller, Mark W., Naviaux, Jane C., Nugent, Nicole R., Qin, Xuejun, Ressler, Kerry J., Risbrough, Victoria B., Rutten, Bart P.F., Stein, Murray B., Ursano, Robert J., Vermetten, Eric, Vinkers, Christiaan H., Wang, Lin, Youssef, Nagy A., Marx, Christine, Grant, Gerry, Stein, Murray, Qin, Xue Jun, Jain, Sonia, McAllister, Thomas W., Zafonte, Ross, Lang, Ariel, Coimbra, Raul, Andaluz, Norberto, Shutter, Lori, George, Mark S., Brancu, Mira, Calhoun, Patrick S., Dedert, Eric, Elbogen, Eric B., Fairbank, John A., Hurley, Robin A., Kilts, Jason D., Kirby, Angela, Marx, Christine E., McDonald, Scott D., Moore, Scott D., Morey, Rajendra A., Naylor, Jennifer C., Rowland, Jared A., Swinkels, Cindy, Szabo, Steven T., Taber, Katherine H., Tupler, Larry A., Van Voorhees, Elizabeth E., Yoash-Gantz, Ruth E., Basu, Archana, Brick, Leslie A., Dalvie, Shareefa, Daskalakis, Nikolaos P., Ensink, Judith B.M., Hemmings, Sian M.J., Herringa, Ryan, Ikiyo, Sylvanus, Koen, Nastassja, Montalvo-Ortiz, Janitza, Nispeling, Danny, Pfeiffer, John, Schijven, Dick, Seedat, Soraya, Shinozaki, Gen, Sumner, Jennifer A., Swart, Patricia, Tyrka, Audrey, Van Zuiden, Mirjam, Wani, Agaz, Wolf, Erika J., Zannas, Anthony, Uddin, Monica, Nievergelt, Caroline M., ACS - Pulmonary hypertension & thrombosis, Graduate School, Adult Psychiatry, ARD - Amsterdam Reproduction and Development, Child Psychiatry, APH - Mental Health, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Global Health, Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Anatomy and neurosciences, MUMC+: MA Psychiatrie (3), Psychiatrie & Neuropsychologie, and RS: MHeNs - R3 - Neuroscience

Subjects
Male, 0301 basic medicine, Oncology, VA Mid-Atlantic MIRECC Workgroup, General Physics and Astronomy, medicine.disease_cause, IMMUNOLOGY, Epigenesis, Genetic, Stress Disorders, Post-Traumatic, Cohort Studies, Epigenome, chemistry.chemical_compound, POSTTRAUMATIC-STRESS-DISORDER, 0302 clinical medicine, Basic Helix-Loop-Helix Transcription Factors, Medicine, DNA METHYLATION, Kynurenine, Stress Disorders, Multidisciplinary, ASSOCIATION, Methylation, Post-Traumatic Stress Disorder (PTSD), Anxiety Disorders, Military Personnel, Mental Health, CpG site, Meta-analysis, DNA methylation, Female, ARYL-HYDROCARBON RECEPTOR, medicine.medical_specialty, Science, behavioral disciplines and activities, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, AGE, Genetic, Clinical Research, Internal medicine, mental disorders, Genetics, Humans, EXPOSURE, Epigenetics, Post-traumatic stress disorder, PGC PTSD Epigenetics Workgroup, business.industry, PROFILES, General Chemistry, DNA Methylation, Immune dysregulation, Repressor Proteins, 030104 developmental biology, chemistry, Case-Control Studies, Post-Traumatic, Wounds and Injuries, Epigenetics analysis, business, 030217 neurology & neurosurgery, INTRuST Clinical Consortium, Epigenesis
Abstract

Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed controls. Here, we describe the results of the largest DNA methylation meta-analysis of PTSD to date. Ten cohorts, military and civilian, contribute blood-derived DNA methylation data from 1,896 PTSD cases and trauma-exposed controls. Four CpG sites within the aryl-hydrocarbon receptor repressor (AHRR) associate with PTSD after adjustment for multiple comparisons, with lower DNA methylation in PTSD cases relative to controls. Although AHRR methylation is known to associate with smoking, the AHRR association with PTSD is most pronounced in non-smokers, suggesting the result was independent of smoking status. Evaluation of metabolomics data reveals that AHRR methylation associated with kynurenine levels, which are lower among subjects with PTSD. This study supports epigenetic differences in those with PTSD and suggests a role for decreased kynurenine as a contributor to immune dysregulation in PTSD., PTSD has been associated with DNA methylation of specific loci in the genome, but studies have been limited by small sample sizes. Here, the authors perform a meta-analysis of DNA methylation data from 10 different cohorts and identify CpGs in AHRR that are associated with PTSD.

Published
2020

13. Amygdala Nuclei Volume and Shape in Military Veterans With Posttraumatic Stress Disorder

Author

Morey, Rajendra A., primary, Clarke, Emily K., additional, Haswell, Courtney C., additional, Phillips, Rachel D., additional, Clausen, Ashley N., additional, Mufford, Mary S., additional, Saygin, Zeynep, additional, Wagner, H. Ryan, additional, LaBar, Kevin S., additional, Brancu, Mira, additional, Beckham, Jean C., additional, Calhoun, Patrick S., additional, Dedert, Eric, additional, Elbogen, Eric B., additional, Fairbank, John A., additional, Hurley, Robin A., additional, Kilts, Jason D., additional, Kimbrel, Nathan A., additional, Kirby, Angela, additional, Marx, Christine E., additional, McDonald, Scott D., additional, Moore, Scott D., additional, Naylor, Jennifer C., additional, Rowland, Jared, additional, Swinkels, Cindy, additional, Szabo, Steven T., additional, Taber, Katherine H., additional, Tupler, Larry A., additional, van Voorhees, Elizabeth E., additional, and Yoash-Gantz, Ruth E., additional

Published
2020
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15. Relationship between processing speed and executive functioning performance among OEF/OIF veterans: implications for postdeployment rehabilitation

Author

Nelson, Lonnie A., Yoash-Gantz, Ruth E., Pickett, Treven C., and Campbell, Thomas A.

Subjects
Cognitive therapy -- Demographic aspects, Cognitive therapy -- Patient outcomes, Cognitive therapy -- Research, Deployment (Strategy) -- Psychological aspects, Deployment (Strategy) -- Research, Human information processing -- Demographic aspects, Human information processing -- Physiological aspects, Human information processing -- Research, Post-traumatic stress disorder -- Demographic aspects, Post-traumatic stress disorder -- Patient outcomes, Post-traumatic stress disorder -- Research, Veterans -- Psychological aspects, Veterans -- Research, Brain -- Injuries, Brain -- Demographic aspects, Brain -- Patient outcomes, Brain -- Research, Business, Health, Health care industry
Published
2009

16. Behavioral and Health Outcomes Associated With Deployment and Nondeployment Acquisition of Traumatic Brain Injury in Iraq and Afghanistan Veterans

Author

Martindale, Sarah L., primary, Epstein, Erica L., additional, Taber, Katherine H., additional, Rowland, Jared A., additional, Brancu, Mira, additional, Beckham, Jean C., additional, Calhoun, Patrick S., additional, Dedert, Eric, additional, Elbogen, Eric B., additional, Fairbank, John A., additional, Green, Kimberly T., additional, Hurley, Robin A., additional, Kilts, Jason D., additional, Kimbrel, Nathan, additional, Kirby, Angela, additional, Marx, Christine E., additional, McCarthy, Gregory, additional, McDonald, Scott D., additional, Miller-Mumford, Marinell, additional, Moore, Scott D., additional, Morey, Rajendra A., additional, Naylor, Jennifer C., additional, Pickett, Treven C., additional, Runnals, Jennifer J., additional, Swinkels, Cindy, additional, Szabo, Steven T., additional, Tupler, Larry A., additional, Van Voorhees, Elizabeth E., additional, Wagner, H. Ryan, additional, Weiner, Richard D., additional, and Yoash-Gantz, Ruth E., additional

Published
2018
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17. Amygdala Nuclei Volume and Shape in Military Veterans With Posttraumatic Stress Disorder

Author

Morey, Rajendra A., Clarke, Emily K., Haswell, Courtney C., Phillips, Rachel D., Clausen, Ashley N., Mufford, Mary S., Saygin, Zeynep, Brancu, ira, Beckham, Jean C., Calhoun, Patrick S., Dedert, Eric, Elbogen, Eric B., Fairbank, John A., Hurley, Robin A., Kilts, Jason D., Kimbrel, Nathan A., Kirby, Angela, Marx, Christine E., McDonald, Scott D., Moore, Scott D., Naylor, Jennifer C., Rowland, Jared, Swinkels, Cindy, Szabo, Steven T., Taber, Katherine H., Tupler, Larry A., van Voorhees, Elizabeth E., Yoash-Gantz, Ruth E., Wagner, H. Ryan, and LaBar, Kevin S.

Abstract

The amygdala is a subcortical structure involved in socioemotional and associative fear learning processes relevant for understanding the mechanisms of posttraumatic stress disorder (PTSD). Research in animals indicates that the amygdala is a heterogeneous structure in which the basolateral and centromedial divisions are susceptible to stress. While the amygdala complex is implicated in the pathophysiology of PTSD, little is known about the specific contributions of the individual nuclei that constitute the amygdala complex.

Published
2024
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22. Embedded Performance Validity Measures with Postdeployment Veterans: Cross-Validation and Efficiency with Multiple Measures.

Author

Shura, Robert D., Miskey, Holly M., Rowland, Jared A., Yoash-Gantz, Ruth E., and Denning, John H.

Subjects
NEUROPSYCHOLOGICAL tests, MEMORY testing, BRAIN injuries, TEST validity, VISUAL memory, COGNITION, COMPARATIVE studies, LEARNING, RESEARCH methodology, MEDICAL cooperation, MEMORY, PSYCHOLOGY of movement, PHARMACOKINETICS, PSYCHOLOGICAL tests, PSYCHOMETRICS, RESEARCH, RESEARCH evaluation, PSYCHOLOGY of veterans, LOGISTIC regression analysis, EVALUATION research
Abstract

Embedded validity measures support comprehensive assessment of performance validity. The purpose of this study was to evaluate the accuracy of individual embedded measures and to reduce them to the most efficient combination. The sample included 212 postdeployment veterans (average age = 35 years, average education = 14 years). Thirty embedded measures were initially identified as predictors of Green’s Word Memory Test (WMT) and were derived from the California Verbal Learning Test-Second Edition (CVLT-II), Conners’ Continuous Performance Test-Second Edition (CPT-II), Trail Making Test, Stroop, Wisconsin Card Sorting Test-64, the Wechsler Adult Intelligence Scale-Third Edition Letter-Number Sequencing, Rey Complex Figure Test (RCFT), Brief Visuospatial Memory Test-Revised, and the Finger Tapping Test. Eight nonoverlapping measures with the highest area-under-the-curve (AUC) values were retained for entry into a logistic regression analysis. Embedded measure accuracy was also compared to cutoffs found in the existing literature. Twenty-one percent of the sample failed the WMT. Previously developed cutoffs for individual measures showed poor sensitivity (SN) in the current sample except for the CPT-II (Total Errors, SN = .41). The CVLT-II (Trials 1–5 Total) showed the best overall accuracy (AUC = .80). After redundant measures were statistically eliminated, the model included the RCFT (Recognition True Positives), CPT-II (Total Errors), and CVLT-II (Trials 1–5 Total) and increased overall accuracy compared with the CVLT-II alone (AUC = .87). The combination of just 3 measures from the CPT-II, CVLT-II, and RCFT was the most accurate/efficient in predicting WMT performance. [ABSTRACT FROM PUBLISHER]

Published
2016
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