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Incorporating humic acid (HA) into phosphate fertilizers to produce HA-enhanced phosphate fertilizers (HAPs) can improve the migration and availability of fertilizer-derived phosphorus (P) in soil. However, the optimal proportion of HA remains inconsistent. Here, we investigated the effects of HAPs with different HA proportions (0.1–10% w/w) on water-soluble P fixation rate, P migration, P transformation, and soil microorganisms, and analyzed the main P forms in HAP using Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. The results showed that incorporating 0.1% HA had no impact on P migration and transformation, whereas incorporating 0.5–10% HA increased the migration distance and cumulative migration of fertilizer-derived P by 0–5 mm and 17.1–30.3%, respectively, compared with conventional phosphate fertilizer (CP). Meanwhile, HAPs with 0.5–10% HA significantly reduced the water-soluble P fixation rate by 18.3–25.6%, and significantly increased the soil average available P (AP) content in 0–40 mm soil layer around the P application site by 6.2–12.9% relative to CP, partly due to the phosphate monoesters in HAPs. Clustering analysis revealed that 0.5% HA had similar effects relative to higher HA proportions (1% and 5%), and the inhibition of HAP with 0.5% HA on bacteria and fungi was also greater than that of CP due to the high concentration of soil P. Overall, 0.5% was determined to be the optimal amount of HA for HAP production, which provided a theoretical basis for the development of high-efficiency phosphate fertilizer.

Humic acid (HA)-enhanced urea (HAU) is the top-selling efficiency-enhanced urea in China. Comprehensive investigation into the structure and efficacy of HA complex formation with urea (HACU) - the main reaction product during HAU's production - is required to clarify the reaction mechanism between HA and urea, and to provide guidance for the development of high-efficiency HAU.HACU showed discrepant structural and compositional features from raw HA. Nitrogen (N) content in HACU was 7.3 times greater than that of HA. Several high-resolution analytical methods showed a sharp increase of ammonia in the gaseous product during HACU pyrolysis, suggesting that urea contributed N to HACU. HACU was characterized with significantly fewer carboxyl groups than in raw HA, implying that the carboxyl group was the main group in HA to participate in the reaction between HA and urea. The presence of amide-N in HACU verified the structure of the reaction product. Furthermore, both HACU and HA could enhance the biomass in hydroponically grown maize seedlings, but the highest stimulation for HACU came about when its carbon concentrations were 50-100 mg LDuring HAU's production, reaction with N derived from urea to form amide-N decreased the carboxyl groups in HA, leading to higher concentrations for HACU required to achieve the similar bioefficacy of HA. © 2021 Society of Chemical Industry.

Purpose The survival benefits of patients with inoperable hepatocellular carcinoma (HCC) who undergo transarterial chemoembolization (TACE) and receive sorafenib therapy remain controversial. We aimed to identify clinical predictors in patients with inoperable HCC undergoing TACE and receiving sorafenib. Methods Between January 2014 and December 2017, 148 consecutive patients with inoperable HCC who were treated with TACE plus sorafenib were retrospectively analyzed. Critical clinical factors associated with overall survival (OS) were identified by Cox regression model analysis. Kaplan–Meier methods were used to calculate the survival times, which were compared with the log-rank test. Results Macrovascular invasion (MVI), radiologic response and sorafenib-related dermatologic toxicities were identified as independent factors associated with OS. MVI is a known prognostic factor before treatment. The median OS of patients with either radiologic response or dermatologic toxicities was significantly improved compared with that of patients without it (both 23.0 vs. 7.0 months, P P Conclusion The combination of radiologic response and sorafenib-related dermatologic toxicities is the most robust predictor of survival benefits for HCC patients after TACE plus sorafenib therapy. Level of Evidence Level 3.

To identify clinical prognostic and predictive factors in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT) undergoing sorafenib plus transarterial chemoembolization (TACE) and establish a prognostic score for these patients. Between January 2012 and December 2017, 184 consecutive patients with HCC and PVTT were concurrently treated with sorafenib and TACE. Univariate and multivariate analyses were performed to explore the clinical factors independently correlated with overall survival (OS). A prognostic score was then developed to identify different prognoses in an initial cohort and validated in an external cohort (n = 72). In the multivariate analysis, performance status, extension of PVTT, initial radiological response, and sorafenib-related dermatologic toxicity were identified as predictors associated with OS. These factors were used to develop a prognostic score (PPRD score, range from 0 to 11). The median survival was found to decrease as the PPRD score increased, and patients were stratified into a favorable group (0 points), intermediate group (1–4 points), and dismal group (> 4 points). The median survival of patients in the three groups was 34.0 months, 20.0 months, and 7.0 months, respectively (p

The protein, tripartite motif containing 24 (TRIM24) is a member of the TRIM protein family, and acts as a critical co‐regulator of multiple nuclear receptors. TRIM24 is dysregulated in many cancers, including colorectal carcinoma. However, its biological functions and molecular mechanisms with respect to colorectal carcinoma are still largely unknown. In the current study, we found that TRIM24 promotes YAP signaling for driving cell proliferation in colorectal cancer. TRIM24 was significantly upregulated in colorectal carcinoma, and its expression was negatively correlated with the survival of patients. Depletion of TRIM24 impaired the ability of the cancer cells to proliferate and form colonies. Furthermore, this study also revealed the mechanism underlying the recruitment of TRIM24 by the DANCR/KAT6A complex, which is bound to acetylated lysine 23 of histone H3 (H3K23), resulting in binding to the YAP promoter and activation of YAP transcription that ultimately enhances the proliferation of colorectal cancer cells. Our results revealed a novel mechanism involving TRIM24‐YAP signaling for the regulation of colorectal cancer. We also identified TRIM24 as a potential therapeutic molecule for targeting colorectal cancer., Here, we evaluated TRIM24 expression in colorectal cancer, and revealed a positive correlation between TRIM24 expression level and survival prognosis. TRIM24 promotes cell proliferation via YAP signaling. Finally, potential mechanism of DANCR/KAT6A complex on TRIM24 response was explored.

A series of UV-curable waterborne fluorinated polyurethane (UV-WFPU) were prepared successfully based on novel fluorinated side chain extender (F-TMP). The structure of F-TMP and particle size of UV-WFPU dispersions, contact angle (CA) and surface free energy, morphology, and damping property of UV-WFPU films were characterized through Fourier transform infrared spectroscopy, nanoparticle size analysis, contact angle test, scanning electron microscope and dynamic mechanical analysis (DMA), respectively. The results indicated that UV-WFPU dispersions had a particle size between 49.01 and 61.52 nm. The latex particle size and tan δ value of UV-WFPU films increased with the increase in F-TMP contents. The studies of surface properties confirmed that UV-WFPU films based on F-TMP had outstanding hydrophobicity properties. The highest CA of water and lowest surface free energy of UV-WFPU films reached 96.2° and 21.17 mJ/m2, respectively. Meanwhile, the DMA results showed UV-WFPU films possessed great damping property which had the broad temperature range enhanced by F-TMP, with a maximum value at 190.4 °C. The results of mechanical properties showed that the addition of fluorine increased in the tensile strength of the film. And these films have potential application values in the technical fields of damping, anti-corrosion and dust prevention.

Firstly, the urethane acrylate synthesized by IPDI and HEA was reacted with antioxidant 1010 in different proportions to prepare four kinds of macromolecular low odor monomers. Then a series of macromonomers and a macromolecular photo initiator, odorless reactive diluent, and odorless auxiliary were used to prepare a new odorless photocurable coating. The chemical structure of the macromonomer was characterized by Fourier transform infrared (FT-IR). The odor and properties of the coating film were tested. The results show that the macromolecular structure of the material can reduce the odor in the process of preparation and use and improve the properties of the material to a certain extent.

\beginabstract The trend in the DBMS market is to migrate to the cloud for elasticity, high availability, and lower costs. The traditional, monolithic database architecture is difficult to meet these requirements. With the development of high-speed network and new memory technologies, disaggregated data center has become a reality: it decouples various components from monolithic servers into separated resource pools (e.g., compute, memory, and storage) and connects them through a high-speed network. The next generation cloud native databases should be designed for disaggregated data centers. In this paper, we describe the novel architecture of \name, which follows thedisaggregation design paradigm: the CPU resource on compute nodes is decoupled from remote memory pool and storage pool. Each resource pool grows or shrinks independently, providing \revon-demand provisoning at multiple dimensions while improving reliability. We also design our system to mitigate the inherent penalty brought by resource disaggregation, and introduce optimizations such as optimistic locking and index awared prefetching. Compared to the architecture that uses local resources, \name achieves better dynamic resource provisioning capabilities and 5.3 times faster failure recovery speed, while achieving comparable performance. \endabstract

The Radon transform (RT) has been widely used as a powerful tool, especially in exploration geophysics fields, such as multiple removal, interpolation, and velocity analysis. However, the existing strong outlier effects can seriously decrease the accuracy of the traditional RT. Therefore, a robust time-invariant RT (TIRT) is proposed in the mixed time–frequency domain to attenuate the outlier effects by using double L1-norm sparse constraints performed on the data misfit and the Radon model in the time domain. For the TIRT, the forward RT and its adjoint can be implemented in the frequency domain efficiently. Only one matrix inversion for each frequency component is involved in all iterations to speed up the iterations. Then, the 1-D alternating split Bregman (ASB) algorithm is introduced and improved for 2-D Radon model updating efficiently. It involves matrix-vector multiplication operators and two proximity operators. These two proximity operators can guarantee the robustness and sparseness of the proposed method. Numerical examples of synthetic and field data demonstrate the effectiveness and validity of the proposed method. The proposed method is also used for interpolation to decrease the trace interval. After interpolation, seismic data are more continuous with less serrations along the spatial direction and the frequency-wavenumber spectrum is more focused. The interpolated data have wider potential applications in improving the accuracy of the following seismic processing. It should be noted that the proposed robust and efficient RT can also be used in remote sensing and computerized tomography fields instead of the traditional RT.

To evaluate whether AFP classification criteria correlate with tumor response measured using the European Association for the Study of the Liver (EASL) and predicate survival in patients with hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE). Data from 143 consecutive patients with unresectable HCC and elevated AFP (> 20 ng/mL), who underwent TACE as initial treatment between January 2011 and December 2015 were collected, retrospectively. AFP response was classified as follows: complete response, normalization of AFP; partial response, > 50% decrease from baseline; stable disease, − 50 to + 30% change from baseline; or progressive disease, > 30% increase from baseline. Response rates according to AFP and EASL criteria were compared, and associations between the AFP response and overall survival (OS) were evaluated. The k value for agreement between AFP criteria and EASL criteria was 0.52 (moderate), with response rates of 42.7% and 41.3%, respectively (P = 0.811). The OS of responders was significantly longer compared with non-responders for both AFP (21 vs. 6 months, P

PURPOSE To evaluate the value of α-fetoprotein (AFP) classification criteria in predicting tumor response and patient survival and to discuss the agreement between AFP criteria and modified Response Evaluation Criteria In Solid Tumors (mRECIST). MATERIALS AND METHODS Between January 2011 and December 2014, 147 patients with unresectable hepatocellular carcinoma (HCC) with baseline AFP levels ≥ 400 ng/mL who underwent transarterial chemoembolization as initial treatment were retrospectively enrolled for AFP/imaging correlation analysis. AFP-based response was classified as complete response (CR) in cases of AFP level normalization, partial response (PR) in cases of > 50% decrease vs baseline, stable disease (SD) in cases of -50% to +30% change vs baseline, or progressive disease (PD) in cases of > 30% increase vs baseline. Intermethod agreement between the 2 methods was assessed by Cohen κ coefficient. Response rates according to AFP and mRECIST were compared, and the association between response rate and overall survival (OS) was evaluated. RESULTS The κ value for agreement between AFP criteria and mRECIST was 0.549 (ie, moderate), with objective response and disease control rates of 36.1% and 63.3% per AFP criteria and 34.7% and 46.3% per RECIST (P = .807 and P = .003), respectively. Although AFP criteria and mRECIST showed significantly prognostic strata for CR, PR, SD, and PD after chemoembolization (P < .001 for both), some overlap in radiologic PD survival curves was observed. The OS of AFP-based disease control (ie, CR/PR/SD) was significantly longer than that of AFP-based PD among patients with radiologic PD (9.0 vs 6.0 mo; P < .001). CONCLUSIONS The defined AFP response moderately correlated with mRECIST response and yielded accurate prognostic prediction in patients with HCC and AFP levels ≥ 400 ng/mL treated with chemoembolization.

Background Graves’ disease (GD) is the most common cause of hyperthyroidism, and it rarely develops in patients who undergo partial thyroid removal for thyroid cancer. The present study characterized and analyzed the GD development mechanism after partial thyroidectomy for thyroid cancer and suggested optimized treatments for the condition. Methods A retrospective study from January 2013 to March 2017 was conducted in patients where GD occurred after partial thyroidectomy for thyroid cancer. Reviewed laboratory data included free 3,5,3'-triiodothyronine, free thyroxine, thyroid-stimulating hormone (TSH), thyroglobulin (Tg), anti-Tg antibody, anti-peroxidase antibody, and TSH receptor antibody levels. All laboratory indicators included preoperative and postoperative data. In addition, we collected patient neck ultrasound examination records and radioiodine (RAI) uptake test data. Results Among 5,600 patients diagnosed with GD, 5 (0.09%) met the inclusion criteria and were enrolled. Patient mean age was 47.4±9.6 years, and all were female with a papillary thyroid carcinoma stage I diagnosis. The interval between partial thyroidectomy and hyperthyroidism onset ranged from 2 to 25 months. We proposed possible mechanisms for this medical condition and identified several factors accelerating the disease course. To treat GD, a low RAI (30 mCi) dose was prescribed to patients. All exhibited hypothyroidism at a 3- or 6-month follow-up, with stable clinical status at 1-year follow-up. Conclusions GD rarely develops after partial thyroidectomy for thyroid cancer. We recommend a low RAI dose to manage GD and ablate the remnants of thyroid cancer.

Ghost imaging (GI) reconstructs images using a single-pixel or bucket detector, which has the advantages of scattering robustness, wide spectrum, and beyond-visual-field imaging. However, this technique needs large amounts of measurements to obtain a sharp image. Numerous methods are proposed to overcome this disadvantage. Retina-like patterns, as one of the compressive sensing approaches, enhance the imaging quality of the region of interest (ROI) while maintaining measurements. The design of the retina-like patterns determines the performance of the ROI in the reconstructed image. Unlike the conventional method to fill in ROI with random patterns, optimizing retina-like patterns by filling in the ROI with the patterns containing the sparsity prior of objects is proposed. The proposed method is then verified by simulations and experiments compared with conventional GI, retina-like GI, and GI using patterns optimized by principal component analysis. The method using optimized retina-like patterns obtains the best imaging quality in ROI among other methods. Meanwhile, the good generalization capability of the optimized retina-like pattern is also verified. The feature information of the target can be obtained while designing the size and position of the ROI of retina-like patterns to optimize the ROI pattern. The proposed method facilitates the realization of high-quality GI.

Osteosarcoma (OS) is the most prevalent human bone malignancy, and presents a global annual morbidity of approximately five cases per million. Notably, precise and efficient targeted therapy has become the most promising strategy for the treatment of OS; however, there is still an urgent need for the identification of suitable therapeutic targets. Metastasis-associated in colon cancer 1 (MACC1) was first identified in colon tumors by differential display RT-PCR, and was shown to be involved in the regulation of colon tumor growth and metastasis through the hepatocyte growth factor (HGF)/c-Met signaling pathway. Additionally, MACC1 overexpression has been reported to induce the growth of several types of cancers, including glioblastoma multiforme and gastric cancer. However, whether MACC1 also plays a role in the progression of OS remains unclear. In this study, we found that MACC1 was highly expressed in human OS tissues, as well as in U-2OS and MG-63 cells, when compared with normal tissues and osteoblasts, respectively. Our data further indicated that MACC1 expression was correlated with several clinicopathological features of OS. Through in vitro assays, we found that MACC1 depletion markedly suppressed the proliferative ability of both OS cells and endothelial cells, and inhibited the angiogenic capacity of endothelial cells. Similarly, MACC1 depletion inhibited tumor growth, metastasis, and angiogenesis in mice. Mechanistically, we found that MACC1 could bind to the MET promoter, and enhanced the proliferation of both OS cells and endothelial cells through the HGF/c-Met signaling pathway. Furthermore, we show that MACC1 also promoted angiogenesis by regulating microtubule dynamics, thereby promoting the progression of OS. Our results indicate that MACC1 may be a new and promising therapeutic target for the treatment of OS.

Computational ghost imaging (CGI), with the advantages of wide spectrum, low cost, and robustness to light scattering, has been widely used in many applications. The key issue is long time correlations for acceptable imaging quality. To overcome the issue, we propose parallel retina-like computational ghost imaging (PRGI) method to improve the performance of CGI. In the PRGI scheme, sampling and reconstruction are carried out by using the patterns which are divided into blocks from designed retina-like patterns. Then, the reconstructed image of each block is stitched into the entire image corresponding to the object. The simulations demonstrate that the proposed PRGI method can obtain a sharper image while greatly reducing the time cost than CGI based on compressive sensing (CSGI), parallel architecture (PGI), and retina-like structure (RGI), thereby improving the performance of CGI. The proposed method with reasonable structure design and variable selection may lead to improve performance for similar imaging methods and provide a novel technique for real-time imaging applications.

PURPOSE To compare the outcomes of self-expandable metal stent placement and percutaneous gastrostomy (PG) for the treatment of patients with esophageal cancer (EC) and dysphagia. MATERIALS AND METHODS This retrospective observational study consisted of 113 patients with EC and dysphagia who underwent either stent placement (n = 47) or PG (n = 66) at a single center between June 2014 and June 2018. RESULTS There were 63 men and 50 women, with a mean age of 76.5 years (standard deviation 4.9 years). The 2 groups had similar baseline characteristics, except that the PG group had a higher percentage of patients with cervical EC (22.7% vs 2.1%, P < .001). The PG group had better maintenance of nutritional status in terms of reduction in serum albumin level (P = .039) and weight loss (P = .041). Compared with the stent group, the PG group demonstrated a lower incidence of local severe pain (0% vs 21.3%, P < .001) and lower incidence of dislodgment of device (1.5% vs 19.1%, P = .002). The PG group demonstrated longer overall survival compared with the stent group for Stages II and III (201 vs 185 days, P = .034) and Stage IV (122 vs 86 days, P = .001). CONCLUSIONS Compared with stent insertion, PG is associated with better maintenance of nutritional status, fewer complications, and better survival. Thus, PG may be the preferred choice for treating malnutrition in patients with EC and dysphagia.

The survival benefits and which patients with advanced hepatocellular carcinoma (HCC) would benefit from sorafenib plus transarterial chemoembolization (TACE) therapy remain controversial. We aimed to develop a prognostic score model for predicting different prognoses of patients with HCC and portal vein invasion who received sorafenib plus TACE. This observational study included 167 patients with HCC and portal vein invasion undergoing sorafenib combined with TACE from January 2013 to June 2018 at two hospitals. Multivariate Cox regression analysis was performed using a training cohort (n = 83) to identify critical factors associated with survival. Then, a prognostic score model was established to classify different outcomes and confirmed using a validation cohort (n = 84). Three factors were determined to critically impact survival in the training cohort: portal vein invasion extent, sorafenib-related dermatologic response, and initial radiological response. Using the β-coefficients of these factors, a prognostic score was calculated, and the survival time decreased as the score increased. Based on the prognostic score model, three different prognoses of patients with 0 points, 2–3 points, and > 3 points were stratified with a median survival of 38.0 months, 20.0 months, and 7.0 months, respectively (P

In this paper, we propose a graph-based kinship reasoning (GKR) network for kinship verification, which aims to effectively perform relational reasoning on the extracted features of an image pair. Unlike most existing methods which mainly focus on how to learn discriminative features, our method considers how to compare and fuse the extracted feature pair to reason about the kin relations. The proposed GKR constructs a star graph called kinship relational graph where each peripheral node represents the information comparison in one feature dimension and the central node is used as a bridge for information communication among peripheral nodes. Then the GKR performs relational reasoning on this graph with recursive message passing. Extensive experimental results on the KinFaceW-I and KinFaceW-II datasets show that the proposed GKR outperforms the state-of-the-art methods., Accepted to ICME 2020(IEEE International Conference on Multimedia & Expo 2020) as an Oral Presentation

Hongyu Wang,1,* Chuyang Lin,2,* Wenzhe Fan,1 Jiang Zhang,3 Yingqiang Zhang,4 Wang Yao,1 Jiaping Li1 1Department of Interventional Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, People’s Republic of China; 2Department of Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou 510080, People’s Republic of China; 3Department of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, People’s Republic of China; 4Department of Interventional Radiology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiaping LiDepartment of Interventional Oncology, The First Affiliated Hospital of Sun Yat-sen University, No. 58 Zhongshan 2 Road, Guangzhou 510080, People’s Republic of ChinaTel +86-20-13352890908Fax +86-20-87755766Email jpli3s@126.comPurpose: To examine the effect of dynamic changes in neutrophil-to-lymphocyte ratio (NLR) on tumor response and overall survival (OS) in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE).Patients and Methods: Data from 181 patients with HCC were retrospectively collected. White blood cell, neutrophil and lymphocyte counts, and the NLR were obtained 1– 3 days before as well as 3– 6 weeks and 3 months after TACE. Patients were divided into two groups at each time point according to the mean value of NLR, and also divided into continuous decrease, fluctuating increase-decrease (I-D), fluctuating decrease-increase (D-I), and continuous increase groups according to the dynamic changes in the NLR. The dynamic changes in blood counts and NLR were analyzed using repeated-measures ANOVA. The odds ratios (ORs) for tumor response in different NLR groups were examined using a multivariate logistic regression model. Finally, the prognostic value of the dynamic changes in the NLR was examined using Cox regression models.Results: Continuous decline of white blood cell counts, neutrophil counts and lymphocyte counts were observed at 3– 6 weeks and 3 months after TACE treatment. The NLR increased slightly and then decreased substantially in responders, while it increased slightly and then significantly in non-responders, with a significant interaction effect of Time × Tumor response (P = 0.005). NLR grouping before TACE, 3– 6 weeks and 3 months after TACE was not associated with tumor response, and only 3 months after TACE did, it shows a significant difference in univariate survival analyses (NLR > 2.5 vs NLR ≤ 2.5, hazard ratio [HR] = 2.442, 95% confidence interval (CI): 1.545, 3.860). The changes in the NLR were significantly correlated with tumor response and OS. Non-responders for TACE were more common in the continuous NLR increase group (OR = 6.230, 95% CI: 1.848– 21.001) and in the fluctuating D-I group (OR = 5.702, 95% CI: 1.480– 21.957). Multivariate analyses revealed that these two patient groups also showed poorer OS (HR = 2.351, 95% CI: 1.120– 4.605 and HR = 2.320, 95% CI: 1.187– 4.533, respectively).Conclusion: Dynamic changes in the NLR may be better predictors of tumor response and OS than static NLR values, but more data are needed.Keywords: hepatocellular carcinoma, prognosis, neutrophil-to-lymphocyte ratio, transarterial chemoembolization

To identify clinical prognostic and predictive factors in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT) undergoing sorafenib plus transarterial chemoembolization (TACE) and establish a prognostic score for these patients.Between January 2012 and December 2017, 184 consecutive patients with HCC and PVTT were concurrently treated with sorafenib and TACE. Univariate and multivariate analyses were performed to explore the clinical factors independently correlated with overall survival (OS). A prognostic score was then developed to identify different prognoses in an initial cohort and validated in an external cohort (n = 72).In the multivariate analysis, performance status, extension of PVTT, initial radiological response, and sorafenib-related dermatologic toxicity were identified as predictors associated with OS. These factors were used to develop a prognostic score (PPRD score, range from 0 to 11). The median survival was found to decrease as the PPRD score increased, and patients were stratified into a favorable group (0 points), intermediate group (1-4 points), and dismal group ( 4 points). The median survival of patients in the three groups was 34.0 months, 20.0 months, and 7.0 months, respectively (p 0.001). Additionally, the time to progression (TTP) (p 0.001) was stratified along the same prognostic groups. The external validation cohort confirmed the prognostic scores.The proposed score system can accurately stratify the outcomes of patients with HCC and PVTT treated with sorafenib plus TACE to help identify which group of patients may benefit from treatment.• The survival benefits of patients with advanced HCC treated with sorafenib plus TACE remains controversial. • The independent factors associated with survival were identified to develop a prognostic score, called the PPRD score (standing for performance status, PVTT grade, radiological response, and sorafenib-related dermatologic toxicity); the median survival decreases as the score increases. • The scoring system can accurately stratify the survival benefits of patients with HCC and PVTT treated with combination therapy and help to identify which group of patients may benefit from the treatment. Graphical abstract.

An additive flame retardant was prepared from DOPO-HQ. Fourier transform infrared spectroscopy (FT-IR) was used to analyze its chemical structure. It was added to the experimental formula to prepare EP composite material, and the limiting oxygen index experiment and thermogravimetric analysis experiment were carried out on the material, and the scanning electron microscope experiment was carried out on the residual carbon after combustion. The results show that the modified epoxy resin has a limiting oxygen index of 29.5%, and there is no droplet during combustion; thermogravimetric analysis experiments show that the temperature at which the thermal weight loss is 5%wt decreases, but the residual carbon rate increases. Scanning electron microscopy (SEM) test results show that carbon layer formed by the combustion products of epoxy resin is denser..