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Abstract Background Fibrosis with unrelieved chronic inflammation is an important pathological change in keloids. Mitochondrial autophagy plays a crucial role in reducing inflammation and inhibiting fibrosis. Adipose stem cell-derived exosomes, a product of adipose stem cell paracrine secretion, have pharmacological effects, such as anti-inflammatory and antiapoptotic effects, and mediate autophagy. Therefore, this study aims to investigate the function and mechanism of adipose stem cell exosomes in the treatment of keloids. Method We isolated adipose stem cell exosomes under normoxic and hypoxic condition to detect their effects on keloid fibroblast proliferation, migration, and collagen synthesis. Meanwhile, 740YPDGFR (PI3K/AKT activator) was applied to detect the changes in autophagic flow levels and mitochondrial morphology and function in keloid fibroblasts. We constructed a human keloid mouse model by transplanting human keloid tissues into six-week-old (20–22 g; female) BALB/c nude mice, meanwhile, we applied adipose stem cell exosomes to treat the mouse model and observed the retention and effect of ADSC exosomes in vivo. Results ADSC exosomes can inhibit the PI3K/AKT/mTOR signaling pathway. The exosomes of ADSCs decreased the inflammatory level of KFs, enhanced the interaction between P62 and LC3, and restored the mitochondrial membrane potential. In the human keloid mouse model, ADSC exosomes can exist stably, promote mitochondrial autophagy in keloid tissue, improve mitochondrial morphology, reduce inflammatory reaction and fibrosis. Meanwhile, At the same time, the exosomes derived from hypoxic adipose stem cells have played a more effective role in both in vitro and in vivo experiments. Conclusions Adipose stem cell exosomes inhibited the PI3K/AKT/mTOR pathway, activated mitochondrial autophagy, and alleviated keloid scars. Graphical Abstract

Hourly global solar radiation data is an important factor for solar energy utilization. Due to the lack of solar radiation observation stations in many areas, some hourly solar radiation models are proposed to predict hourly solar radiation. However, the existing models perform poorly in heavy fog-haze areas because the weakening effect of fog-haze on solar radiation is not considered. Thus, in this paper, hourly global solar radiation prediction models are developed considering air quality index (AQI) using XGBoost algorithm. The results show a general improvement in the accuracy of models with AQI as an additional input (Model B1-B6) compared to models that do not consider AQI (Model A1-A6). Compared to Model A, Model B have an increase in R value from 0.927 to 0.948, a decrease in RMSE value from 0.300 to 0.282 and a decrease in MAPE value from 0.159 to 0.145. In addition, for hourly solar radiation prediction, the six most important inputs are the day of the year, air temperature difference, surface temperature difference, hour, AQI, and total cloud cover.

Abstract Semiconductor ion fuel cells (SIFCs) have demonstrated impressive ionic conductivity and efficient power generation at temperatures below 600 °C. However, the lack of understanding of the ionic conduction mechanisms associated with composite electrolytes has impeded the advancement of SIFCs toward lower operating temperatures. In this study, a CeO2/β″‐Al2O3 heterostructure electrolyte is introduced, incorporating β″‐Al2O3 and leveraging the local electric field (LEF) as well as the manipulation of the melting point temperature of carbonate/hydroxide (C/H) by Na+ and Mg2+ from β″‐Al2O3. This design successfully maintains swift interfacial conduction of oxygen ions at 350 °C. Consequently, the fuel cell device achieved an exceptional ionic conductivity of 0.019 S/cm and a power output of 85.9 mW/cm2 at 350 °C. The system attained a peak power density of 1 W/cm2 with an ultra‐high ionic conductivity of 0.197 S/cm at 550 °C. The results indicate that through engineering the LEF and incorporating the lower melting point C/H, there approach effectively observed oxygen ion transport at low temperatures (350 °C), effectively overcoming the issue of cell failure at temperatures below 419 °C. This study presents a promising methodology for further developing high‐performance semiconductor ion fuel cells in the low temperature range of 300–600 °C.

Gastrointestinal (GI) cancers represent a significant global health challenge, driving relentless efforts to identify innovative diagnostic and therapeutic approaches. Recent strides in microbiome research have unveiled a previously underestimated dimension of cancer progression that revolves around the intricate metabolic interplay between GI cancers and the host's gut microbiota. This review aims to provide a comprehensive overview of these emerging metabolic interactions and their potential to catalyze a paradigm shift in precision diagnosis and therapeutic breakthroughs in GI cancers. The article underscores the groundbreaking impact of microbiome research on oncology by delving into the symbiotic connection between host metabolism and the gut microbiota. It offers valuable insights into tailoring treatment strategies to individual patients, thus moving beyond the traditional one-size-fits-all approach. This review also sheds light on novel diagnostic methodologies that could transform the early detection of GI cancers, potentially leading to more favorable patient outcomes. In conclusion, exploring the metabolic interactions between host gut microbiota and GI cancers showcases a promising frontier in the ongoing battle against these formidable diseases. By comprehending and harnessing the microbiome's influence, the future of precision diagnosis and therapeutic innovation for GI cancers appears more optimistic, opening doors to tailored treatments and enhanced diagnostic precision.

Thermal and electrical conductivity are essential when selecting materials for certain applications. We first present here an analysis of main influencing factors in electrical conductivity of as-cast Mg binary alloys, particularly the effect of the microsegregation of solutes during solidification. A theoretical model is then developed for electrical conductivity in binary Mg alloys, focusing on the effect of solute type and content, and applied to 8 Mg alloy systems with remarkable agreement. Electrical conductivity is then converted into thermal conductivity by Wiedemann–Franz's law, which is also applied to 8 Mg alloy systems, showing significant consistency. This finding provides an easy method for designing and evaluating the electrical/thermal conductivity for Mg alloys, or may be extended to other alloys.

This article presents a novel and feasible approach for researching the quantity of the ceramic phase and component optimization in high-temperature titanium alloys with small trace amounts of ceramic phases. Different near-α titanium alloys with varying yttrium and boron contents were prepared through the utilization of a vacuum non-consumable arc furnace melting method. The alloy used was a Ti-5.9Al-4Sn-3.9Zr-3.8Mo-0.4Si base. Its microstructure, texture, mechanical properties, and fracture behavior were studied. The observation of the as-cast structure shows that the addition of different doses of trace Y and B elements significantly refines both the original β grains and α grains. Moreover, the addition of the B element transforms the Widmanstätten structure in the titanium alloy structure into a basketweave structure. The addition of Y can refine the grain structure, improve the uniformity of the matrix structure, and act as a strong deoxidizer, which will take away the oxygen in the matrix and purify it. The TiB whiskers generated with the addition of B promotes dynamic recrystallization behavior and leads to more equiaxed α grains being precipitated around them, resulting in a significant refinement of the microstructure of the as-cast alloy. After adding a small amount of B, the texture strength of the α phase is significantly reduced, indicating that TiB whiskers inhibit the formation of texture. After conducting performance screening and structure analysis, the study supplements the analysis of Y’s regulation of the titanium alloy structure. The regulation is primarily explained by combining the results of the analysis of boron content, phase diagram analysis, mechanical properties, and fracture analysis. The mechanical analysis introduces the unique load transfer strengthening of TiB whiskers combined with an analysis of high-temperature mechanical properties, as the threshold for addition. The optimal amounts of Y and B additions are 0.6 wt% and 0.8 wt%, respectively. The optimized alloy obtained under this condition can achieve a tensile strength of 950 Mpa at 500 °C without any plastic deformation or heat treatment.

The enmein-type diterpenoids are a class of anticancer ent-Kaurane diterpnoids that have received much attention in recent years. Herein, a novel 1,14-epoxy enmein-type diterpenoid 4, was reported in this project for the first time. A series of novel enmein-type diterpenoid derivatives were also synthesized and tested for anticancer activities. Among all the derivatives, compound 7h exhibited the most significant inhibitory effect against A549 cells (IC50 = 2.16 µM), being 11.03-folds better than its parental compound 4. Additionally, 7h exhibited relatively weak anti-proliferative activity (IC50 > 100 µM) against human normal L-02 cells, suggesting that it had excellent anti-proliferative selectivity for cancer cells. Mechanism studies suggested that 7h induced G0/G1 arrest and apoptosis in A549 cells by inhibiting the PI3K/AKT/mTOR pathway. This process was associated with elevated intracellular ROS levels and collapsed MMP. In summary, these data identified 7h as a promising lead compound that warrants further investigation of its anticancer properties.

Myocardial infarction (MI) is a prevalent cardiovascular disease characterized by myocardial necrosis resulting from coronary artery ischemia and hypoxia, which can lead to severe complications such as arrhythmia, cardiac rupture, heart failure, and sudden death. Despite being a research hotspot, the etiological mechanism of MI remains unclear. The emergence and widespread use of omics technologies, including genomics, transcriptomics, proteomics, metabolomics, and other omics, have provided new opportunities for exploring the molecular mechanism of MI and identifying a large number of disease biomarkers. However, a single-omics approach has limitations in understanding the complex biological pathways of diseases. The multi-omics approach can reveal the interaction network among molecules at various levels and overcome the limitations of the single-omics approaches. This review focuses on the omics studies of MI, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, and other omics. The exploration extended into the domain of multi-omics integrative analysis, accompanied by a compilation of diverse online resources, databases, and tools conducive to these investigations. Additionally, we discussed the role and prospects of multi-omics approaches in personalized medicine, highlighting the potential for improving diagnosis, treatment, and prognosis of MI.

The combination of semisolid and hot extrusion processing was applied to refine the icosahedral quasicrystalline phase (I-phase) in an extruded Mg-1.92Zn-0.34Y(wt.%) alloy for the first time. The semisolid isothermal heat treatment transformed the micron-sized I-phase particles into nano lamellar eutectic (α-Mg + I-phase) with a lamellar spacing of ~86 nm. After subsequent hot extrusion at 250 °C, the nano lamellar eutectic phases were broken into uniformly dispersed nanoscale I-phase particles. What's more, the matrix microstructure was significantly refined with an equiaxed average grain size of 2.59 ± 0.81 µm, and an unusual texture component (most of the grains’ c-axis is parallel to the extrusion direction) was observed. The processed alloy exhibited a high tensile elongation to failure (EL) of 44 ± 2.6% with an ultimate tensile strength (UTS) of 258 ± 2.0 MPa and a tensile yield strength (TYS) of 176 ± 1.6 MPa at room temperature. The high ductility from the combined effects of the grain refinement, dispersion of nanoscale I-phase particles, and the unusual texture. The uniform dispersion of nanoscale I-phase particles could promote grain refinement by particle stimulated nucleation mechanism, and thus bring the unusual texture (where the c-axis is aligned parallel to the extrusion direction during dynamic recrystallization, which contributed to ductility).

Solidification grain boundary migration (SGBM) occurs in metals and alloys manufactured by casting, welding, or 3D printing, and it affects material properties, but its mechanisms remain largely unknown. Here, the authors show how SGBM can be predicted in various alloys under different conditions.

Aimed at clarifying δ→γ transformation and M23C6 precipitation behavior in18Cr-xAl-Si (x = 0, 0.43wt.%, 0.91wt.% and 1.82wt.%) ferritic heat-resistant stainless steel (FHSS), high temperature confocal scanning laser microscopy (CSLM) was used for in-situ observation during solidification. The results demonstrated that increasing of Al content reduced the nucleation temperature of δ-ferrite, and at the same time reduced the free energy difference between δ-ferrite and γ-austenite, which increased the difficulty of δ→γ transformation, in turn reduced the temperature of δ→γ transformation. The γ-austenite preferentially precipitated at the δ-ferrite phase boundaries and gradually along the sides of the δ-ferrite phase boundaries as the temperature decreased, and part of the martensite transformed inside the γ-austenite phases. M23C6 carbides mainly precipitated at the phase boundaries between δ-ferrite and γ-austenite/martensite. With the increase of Al content, the amount of γ-austenite/martensite and M23C6 carbides decreased. In addition, the solidification mechanism of the complex nucleus was also discussed.

The δ-ferrite/γ-austenite formation and precipitation behavior of 18Cr–Al–Si FHSS (ferritic heat-resistant stainless steel) during solidification has been investigated by a high temperature confocal scanning laser microscopy (CSLM) at the cooling rates from 5 °C min−1 to 100 °C min−1. The results have demonstrated that the increase of cooling rate will decrease nucleation temperature of δ-ferrite phase, which will affect δ-ferrite/γ-austenite formation process, and the δ→γ transformation process all occurred at the texted cooling rates. The γ-austenite phase first precipitated at δ-ferrite phase boundaries and then appeared within δ-ferrite phase, and in the subsequent cooling process, part of the γ-austenite begins to transform into martensite. The content of γ-austenite/martensite phase and M23C6 carbides increased with the increment of cooling rate. In addition, the solidification mechanism of the complex nucleus at the cooling rates of 5 °C min−1 and 100 °C min−1 were also discussed.

This paper dealt with a series of numerical investigations on a new porous cooling channel applied to PV/T systems in order to improve the insufficient heat transfer in the conventional channel. The proposed porous cooling channel based on field synergy theory had a higher overall heat transfer coefficient, which enhanced the total efficiency of the PV/T system. The numerical model was validated with experimental data. The results showed that holes distributed non-uniformly near the outlet of the cooling water led to a better cooling effect, and a hole diameter of 0.005 m led to an optimal performance. The total efficiency of the PV module with the new cooling channel was 4.17% higher than the conventional one at a solar irradiance of 1000 W/m2 and an inlet mass flow rate of 0.006 kg/s. In addition, as the solar irradiance increased from 300 to 1200 W/m2, the total efficiency of the new PV/T system dropped by 5.07%, which included reductions in both the electrical and thermal efficiency. The total efficiency was improved by 18.04% as the inlet mass flow rate of cooling water increased from 0.002 to 0.02 kg/s.

Composite micro-alloying is an important technique for developing cost-effective, high-performance aluminum alloys. Here, the effect of combined addition of Zr, Ti and rare-earth Y on the microstructure and tensile properties of an Al-7.6Zn-1.6 Mg-2.1Cu (wt.%) alloy is systematically investigated by means of X-ray diffraction, optical microscopy, scanning electron microscopy, transmission electron microscopy and room-temperature unixal tensile tests. After adding 0.12 %Zr, 0.04 %Ti and 0.28 %Y, L12-Al3Zr/(Al,Zn)3Zr, AlMgZnTiCuFe and (Al,Zn)8Cu4Y phases were induced; the as-T6 treated microstructure of the base alloy changed from fully recrystallized to fully unrecrystallized, accompanied by strong 〈100〉 + 〈111〉 fiber textures along extrusion direction. As a result, the Al-Zn-Mg-Cu-Zr-Ti-Y alloy with low Zn and Mg contents exhibits an ultimate tensile strength of 692 MPa, yield strength of 647 MPa (∼36 % higher than the base alloy) and 6.8 % elongation. The main strengthening mechanisms responsible for this high yield strength are Orowan dislocation bypassing strengthening (∼449 MPa), fiber texture strengthening, and dispersion strengthening. Moreover, the synergistic strengthening effect of rare-earth Y and transitional element(s) Zr and/or Ti was revealed, which may be related to the formation(s) of nanoscale network-structured Al8Cu4Y and/or L12-Al3(Zr,Y) phase(s). The massive formation of the Al8Cu4Y network structure requires a narrow process window.

In order to study the slope stability of an impervious layer asphalt concrete panel, in this study, the maximum aggregate size used was 19 mm, and a slope flow value test was carried out after changing the gradation index, filler content and bitumen aggregate ratio. The test results showed that the relationship curve between the slope flow value and the test time was mainly divided into three stages for the slope flow value: an almost linear growth stage, a gradual stabilization stage, and a stable stage. The grading index, bitumen aggregate ratio and filler content had an effect on the slope flow value of asphalt concrete. The slope flow value decreased with the increase in the grading index. A reasonable increase in the grading index can increase the slope stability of the asphalt concrete panel. The slope flow value increased with the increase in the filler content and bitumen aggregate ratio. When the filler content exceeded 13%, the slope flow value significantly increased. At the same time, it was also verified that the asphalt concrete slope with the maximum aggregate size of 19 mm had good thermal stability. On this basis, a prediction model of asphalt concrete slope flow value and test time was established. The model considered the effect of different parameters of mix proportion on the slope flow value. The calculation results were in good agreement with the test results.

In the construction process of an asphalt concrete impermeable core wall, the interlayer bonding of the core wall is the weak link of the core wall structure and also the focus of construction, so it is important to carry out research on the influence of interlayer bonding temperature on the bending performance of an asphalt concrete core wall. In this paper, we study whether asphalt concrete core walls could be treated with cold-bonding by fabricating small beam bending specimens with different interlayer bond temperatures and conducting bending tests on them at 2 °C. The effect of temperature variation on the bending performance of the bond surface under the asphalt concrete core wall is studied through experimental data analysis. The test results show that the maximum value of porosity of bituminous concrete specimens is 2.10% at lower bond surface temperature of −25 °C, which does not meet the specification requirement of less than 2%. The bending stress, strain, and deflection of bituminous concrete core wall increase with the increase of bond surface temperature, especially when the bond surface temperature is less than −10 °C. If the lower bonding surface temperature is less than 10 °C, the upper layer of asphalt mixture with large grain size aggregate cannot be effectively buried in the low bond surface, resulting in flat fracture and brittle damage to the specimen, which is detrimental to construction quality; therefore, the bonding surface should be heated so that the temperature of the bottom bonding surface is 30 °C. If the lower bonding surface temperature is 10 °C or above, no heating is required.

Abstract Refractory diabetic wounds can cause persistent inflammation and delayed healing due to hypoxia. Currently, no optimal solution is available. Exosomes of adipose stem cells (ADSCs-exo) may promote skin wound healing, however, molecular mechanisms remains mysterious. We found significantly enhanced survival and proliferation of adipose stem cells after hypoxia induction compared to normoxia. Here, we aimed to investigate if hypoxic adipose stem cells exosomes (HypADSCs-exo) participate in hypoxia adaptability and accelerate diabetic wound healing. Based on high-throughput sequencing, 215 microRNAs (miRNAs) were upregulated and 369 miRNAs downregulated in HypADSCs-exo compared to ADSCs-exo. Up-regulated miR-21-3p, miR-126-5p, miR-31-5p whereas down-regulated gene miR-99b and miR-146-a correlated with wound healing. According to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), miRNAs might regulate cell metabolism, differentiation and Transforming growth factor-β (TGF-β) function. Consistently, HpyADSCs-exo could promote diabetic wounds healing and inhibit inflammation through PI3K/AKT signaling pathway. Collectively, HpyADSCs-exo can promote diabetic wound healing as an alternative strategy to improve wound healing.

The effect of Al content on the high-temperature oxidation (800 and 900 °C) of 18Cr–Al–Si FHSS (ferritic heat-resistant stainless steel) for up to 180 h in air was investigated via the isothermal oxidation method. The oxidation kinetic curves followed a parabolic law. A higher Al content reduced the oxidation rate and improved the oxidation resistance and also promoted the formation of a denser and more continuous Al2O3 film during the early oxidation stages, which provided an effective barrier that hindered the diffusion of oxygen into the matrix. The oxide films that formed on the 0.63Al FHSS and 1.06Al FHSS were composed of spinel MnCr2O4 in the outer layer, MnO and Cr2O3 in the middle layer, and Al2O3 and SiO2 in the inner layer. The middle layer of 0.63Al FHSS also contained a small amount of Fe2O3. The oxidation mechanism was also discussed based on oxidation kinetics, morphological observations, and phase analysis of oxide films.

Myocardial infarction knowledge base (MIKB; http://www.sysbio.org.cn/mikb/; latest update: December 31, 2020) is an open-access and manually curated database dedicated to integrating knowledge about MI to improve the efficiency of translational MI research. MIKB is an updated and expanded version of our previous MI Risk Knowledge Base (MIRKB), which integrated MI-related risk factors and risk models for providing help in risk assessment or diagnostic prediction of MI. The updated MIRKB includes 9701 records with 2054 single factors, 209 combined factors, 243 risk models, 37 MI subtypes and 3406 interactions between single factors and MIs collected from 4817 research articles. The expanded functional module, i.e. MIGD, is a database including not only MI associated genetic variants, but also the other multi-omics factors and the annotations for their functional alterations. The goal of MIGD is to provide a multi-omics level understanding of the molecular pathogenesis of MI. MIGD includes 1782 omics factors, 28 MI subtypes and 2347 omics factor-MI interactions as well as 1253 genes and 6 chromosomal alterations collected from 2647 research articles. The functions of MI associated genes and their interaction with drugs were analyzed. MIKB will be continuously updated and optimized to provide precision and comprehensive knowledge for the study of heterogeneous and personalized MI.

Four kinds of 7xxx series aluminum alloys with different Y elementcontents were obtained by ordinary gravity casting. The effect of Y content on the microstructure and mechanical properties of as-cast and as-solutionized Al-7.9Zn-3Mg-2.4Cu-0.13Zr (wt%) alloys were investigated by means of x-ray diffraction (XRD), electron backscattering diffraction (EBSD), scanning electron microscopy (SEM), energy dispersive spectrometer (EDS) and room-temperature tensile tests. The results shows that, in as-cast condition, Y element can refine the grain and reduce the content of Mg(Zn, Cu, Al) _2 lamellar phases at the interdendritic. (Al, Zn) _8 Cu _4 Y block-shaped phases form in interdendritic regions. After solution treatment, the undissolved Mg(Zn, Cu, Al) _2 phases evolved from lamellar to bulk-like which distribution in interdendritic, but no obvious change in (Al, Zn) _8 Cu _4 Y phase. The tensile testing results shows that the optimal yttrium content is 0.45 wt%. At 0.45 wt% Y, the ultimate tensile strength and elongation are 267 MPa and 2.4% in as-cast condition and 420 MPa and 3.6% in as-solutionized condition.

High-strength 2xxx series aluminum alloys (Al-Cu system) have been favored by the aerospace and railway transportation industries. Traditionally, developing new materials with targeted properties is guided by extensive experiments and expert experience, causing the development process to be dismayingly slow and expensive. Here, a Kriging model-based efficient global optimization(EGO) lgorithm is applied to search for new 2xxx series aluminum alloys with high tensile strength in a huge search space. After four iterations, the alloy’s ultimate tensile strength increased by 60 MPa, which is higher than that of the best alloy in the initial data set. This study demonstrates the feasibility of using machine-learning to search for 2xxx alloys with good mechanical performance.

Hydraulic asphalt concrete is virtually impervious. Hydraulic fracturing due to the generation of pore water pressure can be generally excluded for asphalt facings and asphalt cores in embankment dams. However, when some cracks and/or large voids exist in the asphalt core in dams, hydraulic fracturing could take place during reservoir impounding. Cracks and/or large voids may be caused by either earthquake shaking, large differential settlements during construction and operation, or poor construction quality. Therefore, asphalt specimens with either cracks of different depths or large air porosity were prepared, and a model test apparatus was developed to investigate the possibility of hydraulic fracturing. Model tests were conducted on cylindrical asphalt concrete specimens of 100 mm in diameter and 180 mm in height. The top boundary of the specimens was either prevented (restrained) from moving in the vertical direction or free to move (unrestrained). The model test results for asphalt concrete with cracks under unrestraint conditions were numerically back-analysed. The model test results indicated that the cracks in the asphalt concrete under the restraint conditions could experience an “open–close” progress with increasing water pressure. That suggested that if the asphalt concrete were long, low water pressure would trigger a fracturing through the cracks. Under the unrestraint conditions, low water pressure could cause the asphalt specimens with either cracks or large air porosity to fail. The extensional strains at failure were reduced, and the reductions depended on the magnitude of the crack depth or air porosity. Suggestions are given for designing the asphalt core dams to reduce the possibility of the occurrence of cracks and/or dilations in the core, especially for dams in unfavourable geological and topographical conditions. A specialty contractor is preferable to do the asphalt core job to rule out the possibility of a weak bond between the layers and an air porosity larger than 3.0% in the core.

The in situ surface reconstitution of a catalyst for hydrogen evolution refers to its structure evolution induced by strong interactions with reaction intermediates during the hydrogen evolution reaction (HER), which eventually leads to the self-optimization of active sites. In consideration of the superior performance that can be achieved by in situ surface reconstitution, more and more attention has been paid to the relationship between active site structure evolution and the self-optimization of HER activity. More and more in situ and/or operando techniques have been explored to track the dynamic structural evolution of HER catalysts in order to clarify the underlying mechanism. This review summarizes recent advances in various types of reconstruction such as the reconfiguration of crystallinity, morphological evolution, chemical composition evolution, phase transition refactoring, surface defects, and interface refactoring in the HER process. Finally, different perspectives and outlooks are offered to guide future investigations. This review is expected to provide some new clues for a deeper understanding of in situ surface reconfiguration in hydrogen evolution reactions and the targeted design of catalysts with desirable structures.

Since 1978, with the first IVF (in vitro fertilization) baby birth in Manchester (England), more than eight million IVF babies have been born throughout the world, and many new techniques and discoveries have emerged in reproductive medicine. To summarize the modern technology and progress in reproductive medicine, all scientific papers related to reproductive medicine, especially papers related to reproductive translational medicine, were fully searched, manually curated and reviewed. Results indicated whether male reproductive medicine or female reproductive medicine all have made significant progress, and their markers have experienced the progress from karyotype analysis to single-cell omics. However, due to the lack of comprehensive databases, especially databases collecting risk exposures, disease markers and models, prevention drugs and effective treatment methods, the application of the latest precision medicine technologies and methods in reproductive medicine is limited.

The asphalt core itself is a no-joint water barrier in embankment dams and is connected to the concrete plinth on the bottom of the core. A reliable asphalt core-plinth connection is crucial and must remain watertight when the core deforms due to deformations in the embankment and foundation and due to reservoir water pressure. A large number of tension tests were conducted to determine the best ratios, joint thickness and suitable additives for the sandy asphalt mastic (SAM) mix used for the connection. With the ratios of bitumen to filler to sand of 20%:35%:45% and by adding 4% SBS in the bitumen, one got a very suitable composition for the asphalt core-plinth connection in tensile conditions. Model tests were conducted to study the connection behavior when subjected to large shear displacements and high water pressure. The joint model test results indicate that the plane-surface plinth, curved-surface plinth, and plinth with or without copper water-stop showed no significant difference for the connection in the joint shear behavior. However, plinth with copper water-stop is suggested to enhance its tensile and shear behavior.

Ceria based electrolyte materials have shown potential application in low temperature solid oxide fuel cells (LT-SOFCs). In this paper, Sm3+ and Nd3+ co-doped CeO2 (SNDC) and pure CeO2 are synthesized via glycine-nitrate process (GNP) and the electro-chemical properties of the nanocrystalline structure electrolyte are investigated using complementary techniques. The result shows that Sm3+ and Nd3+ have been successfully doped into CeO2 lattice, and has the same cubic fluorite structure before, and after, doping. Sm3+ and Nd3+ co-doped causes the lattice distortion of CeO2 and generates more oxygen vacancies, which results in high ionic conductivity. The fuel cells with the nanocrystalline structure SNDC and CeO2 electrolytes have exhibited excellent electrochemical performances. At 450, 500 and 550 °C, the fuel cell for SNDC can achieve an extraordinary peak power densities of 406.25, 634.38, and 1070.31 mW·cm−2, which is, on average, about 1.26 times higher than those (309.38, 562.50 and 804.69 mW·cm−2) for pure CeO2 electrolyte. The outstanding performance of SNDC cell is closely related to the high ionic conductivity of SNDC electrolyte. Moreover, the encouraging findings suggest that the SNDC can be as potential candidate in LT-SOFCs application.

Abstract Background Tissue engineering has emerged as a promising alternative for small-diameter vascular grafts. The aim of this study was to determine the feasibility of using decellularized aortae of fetal pigs (DAFPs) to construct tissue-engineered, small-diameter vascular grafts and to test the performance and application of DAFPs as vascular tissue-engineered scaffolds in the canine arterial system. Methods DAFPs were prepared by continuous enzymatic digestion. Canine vascular endothelial cells (ECs) were seeded onto DAFPs in vitro and then the vascular grafts were cultured in a custom-designed vascular bioreactor system for 7 days of dynamic culture following 3 days of static culture. The grafts were then transplanted into the common carotid artery of the same seven dogs from which ECs had been derived (two grafts were prepared for each dog with one as a backup; therefore, a total of 14 tissue-engineered blood vessels were prepared). At 1, 3, and 6 months post-transplantation, ultrasonography and contrast-enhanced computed tomography (CT) were used to check the patency of the grafts. Additionally, vascular grafts were sampled for histological and electron microscopic examination. Results Tissue-engineered, small-diameter vascular grafts can be successfully constructed using DAFPs and canine vascular ECs. Ultrasonographic and CT test results confirmed that implanted vascular grafts displayed good patency with no obvious thrombi. Six months after implantation, the grafts had been remodeled and exhibited a similar structure to normal arteries. Immunohistochemical staining showed that cells had evenly infiltrated the tunica media and were identified as muscular fibroblasts. Scanning electron microscopy showed that the graft possessed a complete cell layer, and the internal cells of the graft were confirmed to be ECs by transmission electron microscopy. Conclusions Tissue-engineered, small-diameter vascular grafts constructed using DAFPs and canine vascular ECs can be successfully transplanted to replace the canine common carotid artery. This investigation potentially paves the way for solving a problem of considerable clinical need, i.e., the requirement for small-diameter vascular grafts.

The 0.1C-18Cr-1Al-1Si ferritic heat-resistant stainless steel has attracted considerable attention to high-temperature applications due to its favorable combination of creep and oxidation resistance. In this paper, the microstructural evolution and precipitation behavior of the 0.1C-18Cr-1Al-1Si ferritic heat-resistant stainless steel is studied from the compression deformation data in the temperature range of 850 °C–1050 °C and the strain rate range of 0.01–1 s ^−1 . Experimental results demonstrate that higher temperatures and lower strain rates enhance the dynamic recrystallization (DRX) process with remarkable effectiveness. The main precipitates are proved as the AlN phases and the (Cr,Fe) _23 C _6 carbides during hot deformation. With an increase in the deformation temperature, the size of (Cr,Fe) _23 C _6 and AlN gradually increases, and volume fraction gradually decreases. When the strain rate decreases, the average size and volume fraction of (Cr,Fe) _23 C _6 and AlN gradually increase. At the lower temperatures, the occurrence of dynamic recrystallization (DRX) is strongly influenced by (Cr,Fe) _23 C _6 formed on the grain boundaries, mainly because it causes a pinning effect, which hinders the movement of dislocations and delays the occurrence of the DRX.

Chinese herbal medicine (CHM) evolved through thousands of years of practice and was popular not only among the Chinese population, but also most countries in the world. Blumea balsamifera (L.) DC. as a traditional treatment for wound healing in Li Nationality Medicine has a long history of nearly 2000 years. This study was to evaluate the effects of total flavonoids from Blumea balsamifera (L.) DC. on skin excisional wound on the back of Sprague-Dawley rats, reveal its chemical constitution, and postulate its action mechanism. The rats were divided into five groups and the model groups were treated with 30% glycerol, the positive control groups with Jing Wan Hong (JWH) ointment, and three treatment groups with high dose (2.52 g·kg−1), medium dose (1.26 g·kg−1), and low dose (0.63 g·kg−1) of total flavonoids from B. balsamifera. During 10 consecutive days of treatment, the therapeutic effects of rates were evaluated. On day 1, day 3, day 5, day 7, and day 10 after treatment, skin samples were taken from all the rats for further study. Significant increases of granulation tissue, fibroblast, and capillary vessel proliferation were observed at day 7 in the high dose and positive control groups, compared with the model group, with the method of 4% paraformaldehyde for histopathological examination and immunofluorescence staining. To reveal the action mechanisms of total flavonoids on wound healing, the levels of CD68, vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1), and hydroxyproline were measured at different days. Results showed that total flavonoids had significant effects on rat skin excisional wound healing compared with controls, especially high dose ones (p < 0.05). Furthermore, the total flavonoid extract was investigated phytochemically, and twenty-seven compounds were identified from the total flavonoid sample by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry/diode array detector (UPLC-Q-TOF-MS/DAD), including 16 flavonoid aglucons, five flavonoid glycosides (main peaks in chromatogram), five chlorogenic acid analogs, and 1 coumarin. Reports show that flavonoid glycoside possesses therapeutic effects of curing wounds by inducing neovascularization, and chlorogenic acid also has anti-inflammatory and wound healing activities; we postulated that all the ingredients in total flavonoids sample maybe exert a synergetic effect on wound curing. Accompanied with detection of four growth factors, the upregulation of these key growth factors may be the mechanism of therapeutic activities of total flavonoids. The present study confirmed undoubtedly that flavonoids were the main active constituents that contribute to excisional wound healing, and suggested its action mechanism of improving expression levels of growth factors at different healing phases.